GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3000322	3560	None	38	Human	Functional	pAC50	=	8.9	8.9	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3560	None	38	Human	Functional	pAC50	=	8.9	8.9	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3560	None	38	Human	Functional	pAC50	=	8.9	8.9	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3560	None	38	Human	Functional	pAC50	=	8.9	8.9	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	11693	1825	None	16	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1825	None	16	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1825	None	16	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1825	None	16	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	9933193	1825	None	16	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1825	None	16	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1825	None	16	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	367	3822	None	12	Human	Functional	pAC50	=	8	8.0	-2	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	5487427	3822	None	12	Human	Functional	pAC50	=	8	8.0	-2	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	8592	3822	None	12	Human	Functional	pAC50	=	8	8.0	-2	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL1900528	3822	None	12	Human	Functional	pAC50	=	8	8.0	-2	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3305968	3822	None	12	Human	Functional	pAC50	=	8	8.0	-2	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL4650755	3822	None	12	Human	Functional	pAC50	=	8	8.0	-2	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB01409	3822	None	12	Human	Functional	pAC50	=	8	8.0	-2	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	3775	14473	None	26	Human	Functional	pAC50	=	8	8.0	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201232	14473	None	26	Human	Functional	pAC50	=	8	8.0	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB01625	14473	None	26	Human	Functional	pAC50	=	8	8.0	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	1613	2346	None	53	Human	Functional	pAC50	=	5	5.0	-251	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2346	None	53	Human	Functional	pAC50	=	5	5.0	-251	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2346	None	53	Human	Functional	pAC50	=	5	5.0	-251	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2346	None	53	Human	Functional	pAC50	=	5	5.0	-251	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2346	None	53	Human	Functional	pAC50	=	5	5.0	-251	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2136	3093	None	30	Human	Functional	pAC50	=	5	5.0	-199	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3093	None	30	Human	Functional	pAC50	=	5	5.0	-199	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3093	None	30	Human	Functional	pAC50	=	5	5.0	-199	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3093	None	30	Human	Functional	pAC50	=	5	5.0	-199	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3093	None	30	Human	Functional	pAC50	=	5	5.0	-199	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	5280343	188273	None	124	Human	Functional	pAC50	=	5	5.0	-63	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL1520590	188273	None	124	Human	Functional	pAC50	=	5	5.0	-63	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL50	188273	None	124	Human	Functional	pAC50	=	5	5.0	-63	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	2247	505	None	81	Human	Functional	pAC50	=	5.0	5.0	-323	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	81	Human	Functional	pAC50	=	5.0	5.0	-323	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	81	Human	Functional	pAC50	=	5.0	5.0	-323	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	81	Human	Functional	pAC50	=	5.0	5.0	-323	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	81	Human	Functional	pAC50	=	5.0	5.0	-323	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	4614	5389	None	103	Human	Functional	pAC50	=	5.0	5.0	-131	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
	CHEMBL1071	5389	None	103	Human	Functional	pAC50	=	5.0	5.0	-131	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
	47936	193420	None	88	Human	Functional	pAC50	=	5.0	5.0	-97	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193420	None	88	Human	Functional	pAC50	=	5.0	5.0	-97	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	180	401	None	56	Human	Functional	pAC50	=	6.0	6.0	-309	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	56	Human	Functional	pAC50	=	6.0	6.0	-309	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	56	Human	Functional	pAC50	=	6.0	6.0	-309	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	56	Human	Functional	pAC50	=	6.0	6.0	-309	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	56	Human	Functional	pAC50	=	6.0	6.0	-309	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4940	14468	None	35	Human	Functional	pAC50	=	6.0	6.0	-18	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14468	None	35	Human	Functional	pAC50	=	6.0	6.0	-18	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	5573	67579	None	92	Human	Functional	pAC50	=	5.9	5.9	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1325297	67579	None	92	Human	Functional	pAC50	=	5.9	5.9	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL190044	67579	None	92	Human	Functional	pAC50	=	5.9	5.9	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	DB09089	67579	None	92	Human	Functional	pAC50	=	5.9	5.9	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	4919	206232	None	23	Human	Functional	pAC50	=	5.9	5.9	-5	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL86715	206232	None	23	Human	Functional	pAC50	=	5.9	5.9	-5	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	DB00387	206232	None	23	Human	Functional	pAC50	=	5.9	5.9	-5	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	3316	31758	None	71	Human	Functional	pAC50	=	4.9	4.9	-22	4	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	31758	None	71	Human	Functional	pAC50	=	4.9	4.9	-22	4	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	21109	74997	None	75	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	5	1	5	1.1	COc1ccc(CN2CCNCC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL203266	74997	None	75	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	5	1	5	1.1	COc1ccc(CN2CCNCC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	26248	161537	None	102	Human	Functional	pAC50	=	4.9	4.9	1	11	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161537	None	102	Human	Functional	pAC50	=	4.9	4.9	1	11	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	4413	98071	None	57	Human	Functional	pAC50	=	4.9	4.9	-3	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98071	None	57	Human	Functional	pAC50	=	4.9	4.9	-3	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	9429	202131	None	58	Human	Functional	pAC50	=	4.9	4.9	-588	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	202131	None	58	Human	Functional	pAC50	=	4.9	4.9	-588	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	DB01622	202131	None	58	Human	Functional	pAC50	=	4.9	4.9	-588	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	3658	4105	None	53	Human	Functional	pAC50	=	4.9	4.9	-1258	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4105	None	53	Human	Functional	pAC50	=	4.9	4.9	-1258	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4105	None	53	Human	Functional	pAC50	=	4.9	4.9	-1258	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4105	None	53	Human	Functional	pAC50	=	4.9	4.9	-1258	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4105	None	53	Human	Functional	pAC50	=	4.9	4.9	-1258	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	2220	3132	None	82	Human	Functional	pAC50	=	6.9	6.9	-30	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3132	None	82	Human	Functional	pAC50	=	6.9	6.9	-30	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3132	None	82	Human	Functional	pAC50	=	6.9	6.9	-30	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3132	None	82	Human	Functional	pAC50	=	6.9	6.9	-30	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3132	None	82	Human	Functional	pAC50	=	6.9	6.9	-30	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	68873	43562	None	64	Human	Functional	pAC50	=	4.9	4.9	1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1509	43562	None	64	Human	Functional	pAC50	=	4.9	4.9	1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	443955	204368	None	92	Human	Functional	pAC50	=	4.9	4.9	-11	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	204368	None	92	Human	Functional	pAC50	=	4.9	4.9	-11	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	21158560	112791	None	7	Human	Functional	pAC50	=	4.9	4.9	-3090	2	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1038/s41467-023-40064-9
	CHEMBL3305985	112791	None	7	Human	Functional	pAC50	=	4.9	4.9	-3090	2	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1038/s41467-023-40064-9
	CHEMBL5292015	194535	None	0	Human	Functional	pAC50	=	7.8	7.8	-29	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
	41684	31219	None	105	Human	Functional	pAC50	=	5.9	5.9	-3	32	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31219	None	105	Human	Functional	pAC50	=	5.9	5.9	-3	32	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	4477	36534	None	90	Human	Functional	pAC50	=	5.9	5.9	-12	4	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL1448	36534	None	90	Human	Functional	pAC50	=	5.9	5.9	-12	4	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	5284550	41719	None	15	Human	Functional	pAC50	=	5.9	5.9	-74	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL108947	41719	None	15	Human	Functional	pAC50	=	5.9	5.9	-74	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41719	None	15	Human	Functional	pAC50	=	5.9	5.9	-74	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	DB09167	41719	None	15	Human	Functional	pAC50	=	5.9	5.9	-74	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	3149	12612	None	15	Human	Functional	pAC50	=	4.9	4.9	-38	26	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12612	None	15	Human	Functional	pAC50	=	4.9	4.9	-38	26	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	2333	142333	None	97	Human	Functional	pAC50	=	4.9	4.9	1	14	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142333	None	97	Human	Functional	pAC50	=	4.9	4.9	1	14	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2713	205269	None	82	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205269	None	82	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205269	None	82	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205269	None	82	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205269	None	82	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205269	None	82	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205269	None	82	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	154257	178617	None	67	Human	Functional	pAC50	=	4.8	4.8	-42	19	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178617	None	67	Human	Functional	pAC50	=	4.8	4.8	-42	19	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	68617	205525	None	62	Human	Functional	pAC50	=	4.8	4.8	-18	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205525	None	62	Human	Functional	pAC50	=	4.8	4.8	-18	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205525	None	62	Human	Functional	pAC50	=	4.8	4.8	-18	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	216416	111579	None	48	Human	Functional	pAC50	=	4.8	4.8	-177	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111579	None	48	Human	Functional	pAC50	=	4.8	4.8	-177	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	5048	3131	None	64	Human	Functional	pAC50	=	4.8	4.8	-10000	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	8924	3131	None	64	Human	Functional	pAC50	=	4.8	4.8	-10000	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	9948102	3131	None	64	Human	Functional	pAC50	=	4.8	4.8	-10000	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL462605	3131	None	64	Human	Functional	pAC50	=	4.8	4.8	-10000	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	DB11642	3131	None	64	Human	Functional	pAC50	=	4.8	4.8	-10000	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	107771	120246	None	49	Human	Functional	pAC50	=	4.8	4.8	1	9	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL35228	120246	None	49	Human	Functional	pAC50	=	4.8	4.8	1	9	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	5803	162225	None	84	Human	Functional	pAC50	=	4.8	4.8	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162225	None	84	Human	Functional	pAC50	=	4.8	4.8	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	6127	14497	None	8	Human	Functional	pAC50	=	6.8	6.8	1	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14497	None	8	Human	Functional	pAC50	=	6.8	6.8	1	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB13720	14497	None	8	Human	Functional	pAC50	=	6.8	6.8	1	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	72093	35059	None	9	Human	Functional	pAC50	=	4.8	4.8	-14	28	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35059	None	9	Human	Functional	pAC50	=	4.8	4.8	-14	28	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35059	None	9	Human	Functional	pAC50	=	4.8	4.8	-14	28	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	20628	96546	None	28	Human	Functional	pAC50	=	4.8	4.8	-40	13	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	96546	None	28	Human	Functional	pAC50	=	4.8	4.8	-40	13	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	447715	196925	None	68	Human	Functional	pAC50	=	4.8	4.8	-26	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL566315	196925	None	68	Human	Functional	pAC50	=	4.8	4.8	-26	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	1024	1569	None	27	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	5359318	1569	None	27	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	556	1569	None	27	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	65326	1569	None	27	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	9294	1569	None	27	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL1523964	1569	None	27	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL211456	1569	None	27	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL2146102	1569	None	27	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	DB01364	1569	None	27	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	13314	84231	None	15	Human	Functional	pAC50	=	4.8	4.8	-2	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	CHEMBL22097	84231	None	15	Human	Functional	pAC50	=	4.8	4.8	-2	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	4450	178226	None	69	Human	Functional	pAC50	=	4.8	4.8	-26	11	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	178226	None	69	Human	Functional	pAC50	=	4.8	4.8	-26	11	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	2335	11846	None	22	Human	Functional	pAC50	=	4.8	4.8	-16	34	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11846	None	22	Human	Functional	pAC50	=	4.8	4.8	-16	34	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11846	None	22	Human	Functional	pAC50	=	4.8	4.8	-16	34	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11846	None	22	Human	Functional	pAC50	=	4.8	4.8	-16	34	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	1816	2538	None	102	Human	Functional	pAC50	=	4.8	4.8	-2754	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2538	None	102	Human	Functional	pAC50	=	4.8	4.8	-2754	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2538	None	102	Human	Functional	pAC50	=	4.8	4.8	-2754	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2538	None	102	Human	Functional	pAC50	=	4.8	4.8	-2754	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2538	None	102	Human	Functional	pAC50	=	4.8	4.8	-2754	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4976	203577	None	29	Human	Functional	pAC50	=	5.8	5.8	-123	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	203577	None	29	Human	Functional	pAC50	=	5.8	5.8	-123	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	3036780	107529	None	20	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	46780481	107529	None	20	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107529	None	20	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107529	None	20	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107529	None	20	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL504548	107529	None	20	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	DB06216	107529	None	20	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	5210	33336	None	48	Human	Functional	pAC50	=	4.7	4.7	-18	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1200765	33336	None	48	Human	Functional	pAC50	=	4.7	4.7	-18	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1419	33336	None	48	Human	Functional	pAC50	=	4.7	4.7	-18	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	47936	193420	None	88	Human	Functional	pAC50	=	5.7	5.7	-97	6	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193420	None	88	Human	Functional	pAC50	=	5.7	5.7	-97	6	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	1530	2180	None	50	Human	Functional	pAC50	=	5.7	5.7	-63	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2180	None	50	Human	Functional	pAC50	=	5.7	5.7	-63	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2180	None	50	Human	Functional	pAC50	=	5.7	5.7	-63	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2180	None	50	Human	Functional	pAC50	=	5.7	5.7	-63	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2180	None	50	Human	Functional	pAC50	=	5.7	5.7	-63	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	1971	2864	None	38	Human	Functional	pAC50	=	5.7	5.7	-1023	32	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2864	None	38	Human	Functional	pAC50	=	5.7	5.7	-1023	32	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2864	None	38	Human	Functional	pAC50	=	5.7	5.7	-1023	32	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2864	None	38	Human	Functional	pAC50	=	5.7	5.7	-1023	32	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2864	None	38	Human	Functional	pAC50	=	5.7	5.7	-1023	32	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	3000322	3560	None	38	Human	Functional	pAC50	=	7.7	7.7	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3560	None	38	Human	Functional	pAC50	=	7.7	7.7	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3560	None	38	Human	Functional	pAC50	=	7.7	7.7	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3560	None	38	Human	Functional	pAC50	=	7.7	7.7	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	3108	207285	None	116	Human	Functional	pAC50	=	5.7	5.7	1	7	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL932	207285	None	116	Human	Functional	pAC50	=	5.7	5.7	1	7	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	13789	38375	None	65	Human	Functional	pAC50	=	4.7	4.7	-1	2	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	0	0	3	4.4	C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CCC(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL1463345	38375	None	65	Human	Functional	pAC50	=	4.7	4.7	-1	2	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	0	0	3	4.4	C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CCC(=O)O1	10.1038/s41467-023-40064-9
	26987	948	None	33	Human	Functional	pAC50	=	6.7	6.7	-204	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	948	None	33	Human	Functional	pAC50	=	6.7	6.7	-204	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	948	None	33	Human	Functional	pAC50	=	6.7	6.7	-204	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	948	None	33	Human	Functional	pAC50	=	6.7	6.7	-204	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	948	None	33	Human	Functional	pAC50	=	6.7	6.7	-204	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	213046	2383	None	59	Human	Functional	pAC50	=	5.7	5.7	-173	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2383	None	59	Human	Functional	pAC50	=	5.7	5.7	-173	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2383	None	59	Human	Functional	pAC50	=	5.7	5.7	-173	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2383	None	59	Human	Functional	pAC50	=	5.7	5.7	-173	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2383	None	59	Human	Functional	pAC50	=	5.7	5.7	-173	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	43815	186918	None	64	Human	Functional	pAC50	=	5.7	5.7	-10	20	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186918	None	64	Human	Functional	pAC50	=	5.7	5.7	-10	20	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186918	None	64	Human	Functional	pAC50	=	5.7	5.7	-10	20	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	3081361	93932	None	123	Human	Functional	pAC50	=	4.7	4.7	-33	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93932	None	123	Human	Functional	pAC50	=	4.7	4.7	-33	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	100	3803	None	58	Human	Functional	pAC50	=	5.7	5.7	-89	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3803	None	58	Human	Functional	pAC50	=	5.7	5.7	-89	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3803	None	58	Human	Functional	pAC50	=	5.7	5.7	-89	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3803	None	58	Human	Functional	pAC50	=	5.7	5.7	-89	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3803	None	58	Human	Functional	pAC50	=	5.7	5.7	-89	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	1056	3369	None	116	Human	Functional	pAC50	=	4.7	4.7	-39	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3369	None	116	Human	Functional	pAC50	=	4.7	4.7	-39	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3369	None	116	Human	Functional	pAC50	=	4.7	4.7	-39	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3369	None	116	Human	Functional	pAC50	=	4.7	4.7	-39	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3369	None	116	Human	Functional	pAC50	=	4.7	4.7	-39	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	60753	194682	None	40	Human	Functional	pAC50	=	4.7	4.7	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL533	194682	None	40	Human	Functional	pAC50	=	4.7	4.7	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	187	255	None	39	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	None	39	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	None	39	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	None	39	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	None	39	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	None	39	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	2131	57405	None	25	Human	Functional	pAC50	=	5.7	5.7	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1652	57405	None	25	Human	Functional	pAC50	=	5.7	5.7	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	3236	67607	None	43	Human	Functional	pAC50	=	5.7	5.7	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1902981	67607	None	43	Human	Functional	pAC50	=	5.7	5.7	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	4832	55418	None	17	Human	Functional	pAC50	=	7.6	7.6	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1619528	55418	None	17	Human	Functional	pAC50	=	7.6	7.6	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
	2705	3840	None	64	Human	Functional	pAC50	=	7.6	7.6	-1	9	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3840	None	64	Human	Functional	pAC50	=	7.6	7.6	-1	9	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3840	None	64	Human	Functional	pAC50	=	7.6	7.6	-1	9	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3840	None	64	Human	Functional	pAC50	=	7.6	7.6	-1	9	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3840	None	64	Human	Functional	pAC50	=	7.6	7.6	-1	9	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	124	2979	None	47	Human	Functional	pAC50	=	4.6	4.6	-11481	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2979	None	47	Human	Functional	pAC50	=	4.6	4.6	-11481	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2979	None	47	Human	Functional	pAC50	=	4.6	4.6	-11481	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2979	None	47	Human	Functional	pAC50	=	4.6	4.6	-11481	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2979	None	47	Human	Functional	pAC50	=	4.6	4.6	-11481	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2402	3368	None	62	Human	Functional	pAC50	=	4.6	4.6	-851	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3368	None	62	Human	Functional	pAC50	=	4.6	4.6	-851	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3368	None	62	Human	Functional	pAC50	=	4.6	4.6	-851	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3368	None	62	Human	Functional	pAC50	=	4.6	4.6	-851	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3368	None	62	Human	Functional	pAC50	=	4.6	4.6	-851	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	10184653	10995	None	107	Human	Functional	pAC50	=	4.6	4.6	-26	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	CHEMBL1173655	10995	None	107	Human	Functional	pAC50	=	4.6	4.6	-26	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	127151	35328	None	18	Human	Functional	pAC50	=	4.6	4.6	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	3022645	35328	None	18	Human	Functional	pAC50	=	4.6	4.6	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	CHEMBL14370	35328	None	18	Human	Functional	pAC50	=	4.6	4.6	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	19675	51668	None	43	Human	Functional	pAC50	=	4.6	4.6	-1862	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51668	None	43	Human	Functional	pAC50	=	4.6	4.6	-1862	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	3949	100612	None	50	Human	Functional	pAC50	=	4.6	4.6	-25	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	100612	None	50	Human	Functional	pAC50	=	4.6	4.6	-25	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	54697325	58977	None	35	Human	Functional	pAC50	=	4.6	4.6	2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1689772	58977	None	35	Human	Functional	pAC50	=	4.6	4.6	2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	25382	9155	None	37	Human	Functional	pAC50	=	6.6	6.6	-6	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9155	None	37	Human	Functional	pAC50	=	6.6	6.6	-6	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	3158	56265	None	27	Human	Functional	pAC50	=	5.6	5.6	-891	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56265	None	27	Human	Functional	pAC50	=	5.6	5.6	-891	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	DB01142	56265	None	27	Human	Functional	pAC50	=	5.6	5.6	-891	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	1210	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	917	None	51	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	5833	30482	None	74	Human	Functional	pAC50	=	4.6	4.6	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	CHEMBL1393	30482	None	74	Human	Functional	pAC50	=	4.6	4.6	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	2165	203781	None	71	Human	Functional	pAC50	=	4.6	4.6	-17	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3647519	203781	None	71	Human	Functional	pAC50	=	4.6	4.6	-17	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL682	203781	None	71	Human	Functional	pAC50	=	4.6	4.6	-17	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	2564	206182	None	51	Human	Functional	pAC50	=	4.6	4.6	-239	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL864	206182	None	51	Human	Functional	pAC50	=	4.6	4.6	-239	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	16363	595	None	53	Human	Functional	pAC50	=	5.6	5.6	-501	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	595	None	53	Human	Functional	pAC50	=	5.6	5.6	-501	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	595	None	53	Human	Functional	pAC50	=	5.6	5.6	-501	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	595	None	53	Human	Functional	pAC50	=	5.6	5.6	-501	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	595	None	53	Human	Functional	pAC50	=	5.6	5.6	-501	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	10133	909	None	78	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	145714624	909	None	78	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	4361	909	None	78	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	608	909	None	78	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL240597	909	None	78	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	DB06777	909	None	78	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	60606	61558	None	73	Human	Functional	pAC50	=	4.6	4.6	-13	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61558	None	73	Human	Functional	pAC50	=	4.6	4.6	-13	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	DB00758	61558	None	73	Human	Functional	pAC50	=	4.6	4.6	-13	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	2726	918	None	68	Human	Functional	pAC50	=	5.6	5.6	-794	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	918	None	68	Human	Functional	pAC50	=	5.6	5.6	-794	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	918	None	68	Human	Functional	pAC50	=	5.6	5.6	-794	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	918	None	68	Human	Functional	pAC50	=	5.6	5.6	-794	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	918	None	68	Human	Functional	pAC50	=	5.6	5.6	-794	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2333	142333	None	97	Human	Functional	pAC50	=	5.6	5.6	1	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142333	None	97	Human	Functional	pAC50	=	5.6	5.6	1	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2895	203590	None	41	Human	Functional	pAC50	=	5.6	5.6	-38	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	203590	None	41	Human	Functional	pAC50	=	5.6	5.6	-38	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	DB00924	203590	None	41	Human	Functional	pAC50	=	5.6	5.6	-38	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	31101	728	None	40	Human	Functional	pAC50	=	4.6	4.6	-10232	29	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	728	None	40	Human	Functional	pAC50	=	4.6	4.6	-10232	29	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	728	None	40	Human	Functional	pAC50	=	4.6	4.6	-10232	29	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	728	None	40	Human	Functional	pAC50	=	4.6	4.6	-10232	29	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	728	None	40	Human	Functional	pAC50	=	4.6	4.6	-10232	29	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	131411	15390	None	70	Human	Functional	pAC50	=	4.6	4.6	-10	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	28446253	15390	None	70	Human	Functional	pAC50	=	4.6	4.6	-10	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	CHEMBL1214598	15390	None	70	Human	Functional	pAC50	=	4.6	4.6	-10	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	5591	157529	None	90	Human	Functional	pAC50	=	4.6	4.6	-13	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157529	None	90	Human	Functional	pAC50	=	4.6	4.6	-13	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	2905	14496	None	50	Human	Functional	pAC50	=	6.5	6.5	-10	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1201338	14496	None	50	Human	Functional	pAC50	=	6.5	6.5	-10	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	DB00979	14496	None	50	Human	Functional	pAC50	=	6.5	6.5	-10	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	8612	11258	None	36	Human	Functional	pAC50	=	4.5	4.5	-7	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	6	1	4	2.4	CCN(CC)CCOC(=O)c1ccc(N)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1179047	11258	None	36	Human	Functional	pAC50	=	4.5	4.5	-7	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	6	1	4	2.4	CCN(CC)CCOC(=O)c1ccc(N)cc1Cl	10.1038/s41467-023-40064-9
	2381	662	None	48	Human	Functional	pAC50	=	6.5	6.5	-25	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	374	662	None	48	Human	Functional	pAC50	=	6.5	6.5	-25	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	7128	662	None	48	Human	Functional	pAC50	=	6.5	6.5	-25	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1101	662	None	48	Human	Functional	pAC50	=	6.5	6.5	-25	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	DB00810	662	None	48	Human	Functional	pAC50	=	6.5	6.5	-25	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	123603	882	None	29	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	2684	882	None	29	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	584	882	None	29	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	9658	882	None	29	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	CHEMBL168815	882	None	29	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	DB00185	882	None	29	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	23480	124088	None	23	Human	Functional	pAC50	=	5.5	5.5	-4	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL363295	124088	None	23	Human	Functional	pAC50	=	5.5	5.5	-4	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	2286	3181	None	51	Human	Functional	pAC50	=	6.5	6.5	-19	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3181	None	51	Human	Functional	pAC50	=	6.5	6.5	-19	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3181	None	51	Human	Functional	pAC50	=	6.5	6.5	-19	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3181	None	51	Human	Functional	pAC50	=	6.5	6.5	-19	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3181	None	51	Human	Functional	pAC50	=	6.5	6.5	-19	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2551	793	None	23	Human	Functional	pAC50	=	6.5	6.5	-2	13	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	298	793	None	23	Human	Functional	pAC50	=	6.5	6.5	-2	13	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	488	793	None	23	Human	Functional	pAC50	=	6.5	6.5	-2	13	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL965	793	None	23	Human	Functional	pAC50	=	6.5	6.5	-2	13	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB00411	793	None	23	Human	Functional	pAC50	=	6.5	6.5	-2	13	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	4942	5716	None	50	Human	Functional	pAC50	=	5.4	5.4	-4	11	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1078261	5716	None	50	Human	Functional	pAC50	=	5.4	5.4	-4	11	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB12278	5716	None	50	Human	Functional	pAC50	=	5.4	5.4	-4	11	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	135398745	2912	None	112	Human	Functional	pAC50	=	6.4	6.4	-16	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2912	None	112	Human	Functional	pAC50	=	6.4	6.4	-16	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2912	None	112	Human	Functional	pAC50	=	6.4	6.4	-16	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2912	None	112	Human	Functional	pAC50	=	6.4	6.4	-16	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	2166	3121	None	49	Human	Functional	pAC50	=	5.4	5.4	-28	10	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	305	3121	None	49	Human	Functional	pAC50	=	5.4	5.4	-28	10	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	5910	3121	None	49	Human	Functional	pAC50	=	5.4	5.4	-28	10	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	CHEMBL550	3121	None	49	Human	Functional	pAC50	=	5.4	5.4	-28	10	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	DB01085	3121	None	49	Human	Functional	pAC50	=	5.4	5.4	-28	10	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	2370	622	None	31	Human	Functional	pAC50	=	5.4	5.4	-19	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	297	622	None	31	Human	Functional	pAC50	=	5.4	5.4	-19	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	358	622	None	31	Human	Functional	pAC50	=	5.4	5.4	-19	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	CHEMBL1482	622	None	31	Human	Functional	pAC50	=	5.4	5.4	-19	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	DB01019	622	None	31	Human	Functional	pAC50	=	5.4	5.4	-19	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	319	1323	None	44	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1323	None	44	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1323	None	44	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1323	None	44	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1323	None	44	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1323	None	44	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	6450551	19209	None	106	Human	Functional	pAC50	=	5.4	5.4	1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	5	2	4	4.6	CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1	10.1038/s41467-023-40064-9
	CHEMBL1289926	19209	None	106	Human	Functional	pAC50	=	5.4	5.4	1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	5	2	4	4.6	CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1	10.1038/s41467-023-40064-9
	1427	2011	None	54	Human	Functional	pAC50	=	5.4	5.4	-1778	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2011	None	54	Human	Functional	pAC50	=	5.4	5.4	-1778	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2011	None	54	Human	Functional	pAC50	=	5.4	5.4	-1778	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2011	None	54	Human	Functional	pAC50	=	5.4	5.4	-1778	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2011	None	54	Human	Functional	pAC50	=	5.4	5.4	-1778	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2200	3129	None	46	Human	Functional	pAC50	=	6.4	6.4	-114	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	328	3129	None	46	Human	Functional	pAC50	=	6.4	6.4	-114	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848	3129	None	46	Human	Functional	pAC50	=	6.4	6.4	-114	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	CHEMBL9967	3129	None	46	Human	Functional	pAC50	=	6.4	6.4	-114	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	DB00670	3129	None	46	Human	Functional	pAC50	=	6.4	6.4	-114	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	2540	4399	None	111	Human	Functional	pAC50	=	5.3	5.3	-660	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4399	None	111	Human	Functional	pAC50	=	5.3	5.3	-660	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	124087	1388	None	114	Human	Functional	pAC50	=	6.3	6.3	-2	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1388	None	114	Human	Functional	pAC50	=	6.3	6.3	-2	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1388	None	114	Human	Functional	pAC50	=	6.3	6.3	-2	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1388	None	114	Human	Functional	pAC50	=	6.3	6.3	-2	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1388	None	114	Human	Functional	pAC50	=	6.3	6.3	-2	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	2995	204403	None	53	Human	Functional	pAC50	=	5.3	5.3	-1737	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	204403	None	53	Human	Functional	pAC50	=	5.3	5.3	-1737	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	204403	None	53	Human	Functional	pAC50	=	5.3	5.3	-1737	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	DB01151	204403	None	53	Human	Functional	pAC50	=	5.3	5.3	-1737	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	4746	204889	None	31	Human	Functional	pAC50	=	5.3	5.3	-4	19	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204889	None	31	Human	Functional	pAC50	=	5.3	5.3	-4	19	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204889	None	31	Human	Functional	pAC50	=	5.3	5.3	-4	19	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	11504295	2921	None	47	Human	Functional	pAC50	=	5.3	5.3	-38904	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2921	None	47	Human	Functional	pAC50	=	5.3	5.3	-38904	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2921	None	47	Human	Functional	pAC50	=	5.3	5.3	-38904	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2921	None	47	Human	Functional	pAC50	=	5.3	5.3	-38904	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2921	None	47	Human	Functional	pAC50	=	5.3	5.3	-38904	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2583	3774	None	118	Human	Functional	pAC50	=	5.3	5.3	-2884	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3774	None	118	Human	Functional	pAC50	=	5.3	5.3	-2884	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3774	None	118	Human	Functional	pAC50	=	5.3	5.3	-2884	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3774	None	118	Human	Functional	pAC50	=	5.3	5.3	-2884	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3774	None	118	Human	Functional	pAC50	=	5.3	5.3	-2884	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	103	4151	None	61	Human	Functional	pAC50	=	5.3	5.3	-489	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4151	None	61	Human	Functional	pAC50	=	5.3	5.3	-489	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4151	None	61	Human	Functional	pAC50	=	5.3	5.3	-489	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4151	None	61	Human	Functional	pAC50	=	5.3	5.3	-489	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4151	None	61	Human	Functional	pAC50	=	5.3	5.3	-489	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	1224	1431	None	83	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1431	None	83	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1431	None	83	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1431	None	83	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1431	None	83	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1431	None	83	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	5453	203617	None	102	Human	Functional	pAC50	=	6.2	6.2	-13	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	203617	None	102	Human	Functional	pAC50	=	6.2	6.2	-13	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	3652	4095	None	79	Human	Functional	pAC50	=	6.2	6.2	-23	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	57	4095	None	79	Human	Functional	pAC50	=	6.2	6.2	-23	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809	4095	None	79	Human	Functional	pAC50	=	6.2	6.2	-23	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	CHEMBL21536	4095	None	79	Human	Functional	pAC50	=	6.2	6.2	-23	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	DB15357	4095	None	79	Human	Functional	pAC50	=	6.2	6.2	-23	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	135	2530	None	43	Human	Functional	pAC50	=	5.2	5.2	-1047	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2530	None	43	Human	Functional	pAC50	=	5.2	5.2	-1047	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2530	None	43	Human	Functional	pAC50	=	5.2	5.2	-1047	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2530	None	43	Human	Functional	pAC50	=	5.2	5.2	-1047	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2530	None	43	Human	Functional	pAC50	=	5.2	5.2	-1047	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	5284632	67400	None	13	Human	Functional	pAC50	=	8.2	8.2	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1888176	67400	None	13	Human	Functional	pAC50	=	8.2	8.2	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3084748	67400	None	13	Human	Functional	pAC50	=	8.2	8.2	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00209	67400	None	13	Human	Functional	pAC50	=	8.2	8.2	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	154417	23179	None	60	Human	Functional	pAC50	=	8.2	8.2	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1331216	23179	None	60	Human	Functional	pAC50	=	8.2	8.2	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	2470	3651	None	50	Human	Functional	pAC50	=	5.2	5.2	-100000	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3651	None	50	Human	Functional	pAC50	=	5.2	5.2	-100000	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3651	None	50	Human	Functional	pAC50	=	5.2	5.2	-100000	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3651	None	50	Human	Functional	pAC50	=	5.2	5.2	-100000	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3651	None	50	Human	Functional	pAC50	=	5.2	5.2	-100000	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	71496458	115562	None	87	Human	Functional	pAC50	=	6.2	6.2	-1	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115562	None	87	Human	Functional	pAC50	=	6.2	6.2	-1	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	657202	12528	None	6	Human	Functional	pAC50	=	6.2	6.2	-17	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	CHEMBL1186610	12528	None	6	Human	Functional	pAC50	=	6.2	6.2	-17	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	54682461	84684	None	62	Human	Functional	pAC50	=	5.2	5.2	-1	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84684	None	62	Human	Functional	pAC50	=	5.2	5.2	-1	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	154257	178617	None	67	Human	Functional	pAC50	=	5.2	5.2	-42	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178617	None	67	Human	Functional	pAC50	=	5.2	5.2	-42	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	1385580	29274	None	76	Human	Functional	pAC50	=	5.2	5.2	-776	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615	29274	None	76	Human	Functional	pAC50	=	5.2	5.2	-776	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL13828	29274	None	76	Human	Functional	pAC50	=	5.2	5.2	-776	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB12877	29274	None	76	Human	Functional	pAC50	=	5.2	5.2	-776	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	16351	102728	None	47	Human	Functional	pAC50	=	5.2	5.2	-309	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102728	None	47	Human	Functional	pAC50	=	5.2	5.2	-309	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	DB13256	102728	None	47	Human	Functional	pAC50	=	5.2	5.2	-309	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	4066	204624	None	78	Human	Functional	pAC50	=	7.2	7.2	-4	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204624	None	78	Human	Functional	pAC50	=	7.2	7.2	-4	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	DB01071	204624	None	78	Human	Functional	pAC50	=	7.2	7.2	-4	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	4642	41984	None	28	Human	Functional	pAC50	=	7.2	7.2	-2	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1495	41984	None	28	Human	Functional	pAC50	=	7.2	7.2	-2	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	DB00383	41984	None	28	Human	Functional	pAC50	=	7.2	7.2	-2	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	2774	3866	None	95	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593	3866	None	95	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	7319	3866	None	95	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	CHEMBL1200604	3866	None	95	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB00809	3866	None	95	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB01199	3866	None	95	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	135398737	957	None	93	Human	Functional	pAC50	=	6.1	6.1	-229	43	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	957	None	93	Human	Functional	pAC50	=	6.1	6.1	-229	43	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	957	None	93	Human	Functional	pAC50	=	6.1	6.1	-229	43	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	957	None	93	Human	Functional	pAC50	=	6.1	6.1	-229	43	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	957	None	93	Human	Functional	pAC50	=	6.1	6.1	-229	43	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	24826799	10796	None	104	Human	Functional	pAC50	=	5.1	5.1	-24	20	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10796	None	104	Human	Functional	pAC50	=	5.1	5.1	-24	20	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	19861	207521	None	50	Human	Functional	pAC50	=	7.1	7.1	-3	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	207521	None	50	Human	Functional	pAC50	=	7.1	7.1	-3	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	DB00719	207521	None	50	Human	Functional	pAC50	=	7.1	7.1	-3	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	4150	787	None	39	Human	Functional	pAC50	=	5.1	5.1	-123	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	787	None	39	Human	Functional	pAC50	=	5.1	5.1	-123	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	787	None	39	Human	Functional	pAC50	=	5.1	5.1	-123	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	787	None	39	Human	Functional	pAC50	=	5.1	5.1	-123	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	787	None	39	Human	Functional	pAC50	=	5.1	5.1	-123	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	3294	2004	None	111	Human	Functional	pAC50	=	5.1	5.1	-4466	23	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2004	None	111	Human	Functional	pAC50	=	5.1	5.1	-4466	23	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2004	None	111	Human	Functional	pAC50	=	5.1	5.1	-4466	23	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2004	None	111	Human	Functional	pAC50	=	5.1	5.1	-4466	23	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2004	None	111	Human	Functional	pAC50	=	5.1	5.1	-4466	23	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	2337	3254	None	77	Human	Functional	pAC50	=	5.1	5.1	-177	29	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3254	None	77	Human	Functional	pAC50	=	5.1	5.1	-177	29	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3254	None	77	Human	Functional	pAC50	=	5.1	5.1	-177	29	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3254	None	77	Human	Functional	pAC50	=	5.1	5.1	-177	29	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3254	None	77	Human	Functional	pAC50	=	5.1	5.1	-177	29	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	3042	1413	None	35	Human	Functional	pAC50	=	5.1	5.1	-263	17	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1413	None	35	Human	Functional	pAC50	=	5.1	5.1	-263	17	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1413	None	35	Human	Functional	pAC50	=	5.1	5.1	-263	17	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1413	None	35	Human	Functional	pAC50	=	5.1	5.1	-263	17	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1413	None	35	Human	Functional	pAC50	=	5.1	5.1	-263	17	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	1201549	596	None	24	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	596	None	24	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	596	None	24	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	596	None	24	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	596	None	24	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	596	None	24	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	24821094	67092	None	93	Human	Functional	pAC50	=	5.0	5.0	-4	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67092	None	93	Human	Functional	pAC50	=	5.0	5.0	-4	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	636403	188266	None	22	Human	Functional	pAC50	=	5	5.0	-3	7	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188266	None	22	Human	Functional	pAC50	=	5	5.0	-3	7	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	2267	559	None	71	Human	Functional	pAC50	=	5	5.0	-416	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	559	None	71	Human	Functional	pAC50	=	5	5.0	-416	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	559	None	71	Human	Functional	pAC50	=	5	5.0	-416	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	559	None	71	Human	Functional	pAC50	=	5	5.0	-416	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	559	None	71	Human	Functional	pAC50	=	5	5.0	-416	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	129456	207170	None	14	Human	Functional	pEC50	=	10.4	10.4	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	207170	None	14	Human	Functional	pEC50	=	10.4	10.4	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	10104167	2057	None	2	Human	Functional	pEC50	=	9.6	9.6	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	6937	2057	None	2	Human	Functional	pEC50	=	9.6	9.6	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL3121473	2057	None	2	Human	Functional	pEC50	=	9.6	9.6	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	42599070	16076	None	0	Human	Functional	pEC50	=	7	7.0	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	370	4	0	3	4.1	CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223804	16076	None	0	Human	Functional	pEC50	=	7	7.0	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	370	4	0	3	4.1	CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	137630848	161114	None	0	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4061390	161114	None	0	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117131	161114	None	0	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	10386	161166	None	16	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4092348	161166	None	16	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117554	161166	None	16	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	2230	465	None	60	Human	Functional	pEC50	=	5	5.0	1	9	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	296	465	None	60	Human	Functional	pEC50	=	5	5.0	1	9	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	CHEMBL7303	465	None	60	Human	Functional	pEC50	=	5	5.0	1	9	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	DB04365	465	None	60	Human	Functional	pEC50	=	5	5.0	1	9	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	2551	793	None	23	Human	Functional	pEC50	=	7.0	7.0	-2	13	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	298	793	None	23	Human	Functional	pEC50	=	7.0	7.0	-2	13	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	488	793	None	23	Human	Functional	pEC50	=	7.0	7.0	-2	13	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	CHEMBL965	793	None	23	Human	Functional	pEC50	=	7.0	7.0	-2	13	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	DB00411	793	None	23	Human	Functional	pEC50	=	7.0	7.0	-2	13	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	49799920	10540	None	0	Human	Functional	pEC50	=	6.0	6.0	-6	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL1169506	10540	None	0	Human	Functional	pEC50	=	6.0	6.0	-6	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	11120503	4193	None	0	Human	Functional	pEC50	=	6.0	6.0	-16	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL100163	4193	None	0	Human	Functional	pEC50	=	6.0	6.0	-16	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	137629935	161018	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	44329977	111408	None	0	Human	Functional	pEC50	=	8.0	8.0	-10	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL327269	111408	None	0	Human	Functional	pEC50	=	8.0	8.0	-10	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2	10.1016/s0960-894x(98)00509-5
	44589681	185286	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	5	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	387	5	2	6	1.5	NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.032
	CHEMBL485913	185286	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	5	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	387	5	2	6	1.5	NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.032
	22745278	187061	None	1	Human	Functional	pEC50	=	7.9	7.9	-5	5	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	372	3	1	5	2.6	CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.023
	CHEMBL491209	187061	None	1	Human	Functional	pEC50	=	7.9	7.9	-5	5	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	372	3	1	5	2.6	CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.023
	2551	793	None	23	Human	Functional	pEC50	=	7.0	7.0	-2	13	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	298	793	None	23	Human	Functional	pEC50	=	7.0	7.0	-2	13	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	488	793	None	23	Human	Functional	pEC50	=	7.0	7.0	-2	13	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	CHEMBL965	793	None	23	Human	Functional	pEC50	=	7.0	7.0	-2	13	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	DB00411	793	None	23	Human	Functional	pEC50	=	7.0	7.0	-2	13	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	10104047	21635	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21635	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	137629935	161018	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191002	123610	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F	10.1016/j.bmcl.2015.08.011
	CHEMBL3618445	123610	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F	10.1016/j.bmcl.2015.08.011
	170332	160974	None	1	Human	Functional	pEC50	=	4.9	4.9	-2	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Functional	pEC50	=	4.9	4.9	-2	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Functional	pEC50	=	4.9	4.9	-2	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	3652	4095	None	79	Human	Functional	pEC50	=	6.9	6.9	-23	15	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	57	4095	None	79	Human	Functional	pEC50	=	6.9	6.9	-23	15	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	60809	4095	None	79	Human	Functional	pEC50	=	6.9	6.9	-23	15	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	CHEMBL21536	4095	None	79	Human	Functional	pEC50	=	6.9	6.9	-23	15	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	DB15357	4095	None	79	Human	Functional	pEC50	=	6.9	6.9	-23	15	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	44303017	200831	None	0	Human	Functional	pEC50	=	5.9	5.9	-19	2	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60101	200831	None	0	Human	Functional	pEC50	=	5.9	5.9	-19	2	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	42598829	16078	None	0	Human	Functional	pEC50	=	5.9	5.9	-158	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	358	3	0	5	3.9	CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223806	16078	None	0	Human	Functional	pEC50	=	5.9	5.9	-158	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	358	3	0	5	3.9	CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	45786849	157803	None	34	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4083241	157803	None	34	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	44330073	208428	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	327	3	0	5	3.1	C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL99884	208428	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	327	3	0	5	3.1	C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44209166	59554	None	0	Human	Functional	pEC50	=	7.9	7.9	7	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)	ChEMBL	193	1	0	4	1.0	Cc1noc(C2(C)CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL171721	59554	None	0	Human	Functional	pEC50	=	7.9	7.9	7	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)	ChEMBL	193	1	0	4	1.0	Cc1noc(C2(C)CN3CCC2C3)n1	10.1021/jm00083a016
	44303408	201944	None	0	Human	Functional	pEC50	=	5.8	5.8	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60777	201944	None	0	Human	Functional	pEC50	=	5.8	5.8	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10451242	203112	None	0	Human	Functional	pEC50	=	5.8	5.8	-218	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL64029	203112	None	0	Human	Functional	pEC50	=	5.8	5.8	-218	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	122189496	123334	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	499	5	2	3	5.4	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616500	123334	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	499	5	2	3	5.4	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	89777356	155880	None	0	Human	Functional	pEC50	=	5.8	5.8	-72	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	353	3	2	6	2.5	Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4060475	155880	None	0	Human	Functional	pEC50	=	5.8	5.8	-72	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	353	3	2	6	2.5	Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	53385782	74311	None	0	Human	Functional	pEC50	=	5.8	5.8	-56	3	Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay	ChEMBL	399	4	1	4	3.3	CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2	10.1016/j.bmcl.2012.03.088
	CHEMBL2024331	74311	None	0	Human	Functional	pEC50	=	5.8	5.8	-56	3	Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay	ChEMBL	399	4	1	4	3.3	CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2	10.1016/j.bmcl.2012.03.088
	424727	161172	None	2	Human	Functional	pEC50	=	4.8	4.8	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4095774	161172	None	2	Human	Functional	pEC50	=	4.8	4.8	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117601	161172	None	2	Human	Functional	pEC50	=	4.8	4.8	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	129456	207170	None	14	Human	Functional	pEC50	=	7.7	7.7	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	207170	None	14	Human	Functional	pEC50	=	7.7	7.7	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	24967746	16053	None	0	Human	Functional	pEC50	=	7.7	7.7	-50	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	403	5	1	4	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223754	16053	None	0	Human	Functional	pEC50	=	7.7	7.7	-50	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	403	5	1	4	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	9820835	116773	None	4	Human	Functional	pEC50	=	5.7	5.7	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	179	2	1	5	0.1	CCn1nnc(C2=CCCNC2)n1	10.1021/jm00050a006
	CHEMBL337676	116773	None	4	Human	Functional	pEC50	=	5.7	5.7	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	179	2	1	5	0.1	CCn1nnc(C2=CCCNC2)n1	10.1021/jm00050a006
	9927975	4187	None	0	Human	Functional	pEC50	=	8.7	8.7	-10	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	341	3	0	5	3.5	C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL100147	4187	None	0	Human	Functional	pEC50	=	8.7	8.7	-10	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	341	3	0	5	3.5	C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	145973726	164628	None	0	Human	Functional	pEC50	=	5.7	5.7	-36	2	Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response	ChEMBL	356	2	1	5	3.3	Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.10.053
	CHEMBL4216213	164628	None	0	Human	Functional	pEC50	=	5.7	5.7	-36	2	Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response	ChEMBL	356	2	1	5	3.3	Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.10.053
	137629935	161018	None	0	Human	Functional	pEC50	=	4.7	4.7	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Functional	pEC50	=	4.7	4.7	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Functional	pEC50	=	4.7	4.7	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191003	123611	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	6	3	3	4.9	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618446	123611	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	6	3	3	4.9	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	137635723	156081	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	411	3	2	9	2.5	Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4062934	156081	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	411	3	2	9	2.5	Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	187	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	294	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	65	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	8593	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	CHEMBL667	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	DB03128	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	187	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	294	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	65	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	8593	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	CHEMBL667	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	DB03128	255	None	39	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	137630667	161090	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4100938	161090	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116890	161090	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	57230548	173231	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL4524085	173231	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	44330080	107718	None	0	Human	Functional	pEC50	=	6.6	6.6	-8	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL319109	107718	None	0	Human	Functional	pEC50	=	6.6	6.6	-8	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44303018	202021	None	0	Human	Functional	pEC50	=	5.6	5.6	-218	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60833	202021	None	0	Human	Functional	pEC50	=	5.6	5.6	-218	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137631026	161148	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4093215	161148	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117321	161148	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	137628799	160991	None	0	Human	Functional	pEC50	=	4.6	4.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4064668	160991	None	0	Human	Functional	pEC50	=	4.6	4.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116150	160991	None	0	Human	Functional	pEC50	=	4.6	4.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	122189499	123335	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	441	3	2	3	4.0	CN1CCCC/C1=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2	10.1016/j.bmcl.2015.08.011
	CHEMBL3616504	123335	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	441	3	2	3	4.0	CN1CCCC/C1=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2	10.1016/j.bmcl.2015.08.011
	10686494	100536	None	0	Human	Functional	pEC50	=	6.6	6.6	-16	3	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1016/s0960-894x(98)00509-5
	CHEMBL291351	100536	None	0	Human	Functional	pEC50	=	6.6	6.6	-16	3	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1016/s0960-894x(98)00509-5
	10686494	100536	None	0	Human	Functional	pEC50	=	6.6	6.6	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	CHEMBL291351	100536	None	0	Human	Functional	pEC50	=	6.6	6.6	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	122191007	123614	None	0	Human	Functional	pEC50	=	6.6	6.6	1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	449	5	2	3	4.5	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618449	123614	None	0	Human	Functional	pEC50	=	6.6	6.6	1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	449	5	2	3	4.5	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	42598357	16103	None	0	Human	Functional	pEC50	=	5.6	5.6	-794	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	383	4	0	6	3.8	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223863	16103	None	0	Human	Functional	pEC50	=	5.6	5.6	-794	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	383	4	0	6	3.8	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42598359	16104	None	0	Human	Functional	pEC50	=	5.6	5.6	-199	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	436	5	0	7	3.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223864	16104	None	0	Human	Functional	pEC50	=	5.6	5.6	-199	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	436	5	0	7	3.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	25207745	16124	None	0	Human	Functional	pEC50	=	5.6	5.6	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	413	6	0	7	3.5	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223941	16124	None	0	Human	Functional	pEC50	=	5.6	5.6	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	413	6	0	7	3.5	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	89777060	157119	None	0	Human	Functional	pEC50	=	5.6	5.6	-114	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	397	3	2	7	2.5	Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4074908	157119	None	0	Human	Functional	pEC50	=	5.6	5.6	-114	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	397	3	2	7	2.5	Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	5487543	205644	None	4	Human	Functional	pEC50	=	4.6	4.6	-162	6	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	CHEMBL81878	205644	None	4	Human	Functional	pEC50	=	4.6	4.6	-162	6	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	11725107	100611	None	0	Human	Functional	pEC50	=	5.6	5.6	-134	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL291872	100611	None	0	Human	Functional	pEC50	=	5.6	5.6	-134	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137629887	161008	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4065555	161008	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116259	161008	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	10375002	24144	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	178	2	1	4	0.7	CCn1ncc(C2=CCCNC2)n1	10.1021/jm00050a006
	CHEMBL133905	24144	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	178	2	1	4	0.7	CCn1ncc(C2=CCCNC2)n1	10.1021/jm00050a006
	44158142	188668	None	43	Rat	Functional	pEC50	=	5.6	5.6	-1	4	Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1016/j.bmcl.2009.11.089
	CHEMBL503735	188668	None	43	Rat	Functional	pEC50	=	5.6	5.6	-1	4	Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1016/j.bmcl.2009.11.089
	5487543	205644	None	4	Human	Functional	pEC50	=	4.6	4.6	-162	6	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1016/s0960-894x(98)00509-5
	CHEMBL81878	205644	None	4	Human	Functional	pEC50	=	4.6	4.6	-162	6	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1016/s0960-894x(98)00509-5
	650899	54412	None	11	Human	Functional	pEC50	=	4.6	4.6	-10	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	CHEMBL1535797	54412	None	11	Human	Functional	pEC50	=	4.6	4.6	-10	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	CHEMBL1609153	54412	None	11	Human	Functional	pEC50	=	4.6	4.6	-10	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	44158142	188668	None	43	Rat	Functional	pEC50	=	5.6	5.6	-1	4	Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1021/jm900286j
	CHEMBL503735	188668	None	43	Rat	Functional	pEC50	=	5.6	5.6	-1	4	Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1021/jm900286j
	57088082	173232	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL4524086	173232	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	53414666	159299	None	8	Human	Functional	pEC50	=	4.5	4.5	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4099673	159299	None	8	Human	Functional	pEC50	=	4.5	4.5	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	178030	21369	None	31	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	5	0.4	CCn1nnc(C2=CCCN(C)C2)n1	10.1016/j.bmcl.2015.08.011
	CHEMBL131428	21369	None	31	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	5	0.4	CCn1nnc(C2=CCCN(C)C2)n1	10.1016/j.bmcl.2015.08.011
	129456	207170	None	14	Human	Functional	pEC50	=	8.5	8.5	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	207170	None	14	Human	Functional	pEC50	=	8.5	8.5	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	137629935	161018	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	137629935	161018	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191006	123613	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	523	6	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)CCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618448	123613	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	523	6	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)CCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	3652	4095	None	79	Human	Functional	pEC50	=	6.4	6.4	-23	15	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	57	4095	None	79	Human	Functional	pEC50	=	6.4	6.4	-23	15	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	60809	4095	None	79	Human	Functional	pEC50	=	6.4	6.4	-23	15	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	CHEMBL21536	4095	None	79	Human	Functional	pEC50	=	6.4	6.4	-23	15	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	DB15357	4095	None	79	Human	Functional	pEC50	=	6.4	6.4	-23	15	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	42598360	16102	None	0	Human	Functional	pEC50	=	6.4	6.4	-158	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	388	5	0	6	4.0	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223862	16102	None	0	Human	Functional	pEC50	=	6.4	6.4	-158	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	388	5	0	6	4.0	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	87934	98079	None	24	Human	Functional	pEC50	=	6.4	6.4	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	CHEMBL273308	98079	None	24	Human	Functional	pEC50	=	6.4	6.4	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	CHEMBL542883	98079	None	24	Human	Functional	pEC50	=	6.4	6.4	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	122191004	123331	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	521	7	3	4	4.7	COc1ccc(CCN/C(C)=N/c2ccc3c(c2)[C@@H](NC(=O)c2ccc(Br)cc2)[C@H](O)C3)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616497	123331	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	521	7	3	4	4.7	COc1ccc(CCN/C(C)=N/c2ccc3c(c2)[C@@H](NC(=O)c2ccc(Br)cc2)[C@H](O)C3)cc1	10.1016/j.bmcl.2015.08.011
	122191001	123609	None	0	Human	Functional	pEC50	=	6.4	6.4	-9	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1cccc(F)c1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618444	123609	None	0	Human	Functional	pEC50	=	6.4	6.4	-9	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1cccc(F)c1	10.1016/j.bmcl.2015.08.011
	187	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	647412	27317	None	9	Human	Functional	pEC50	=	4.3	4.3	-3	4	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	325	6	2	5	1.7	CCOC(=O)N1CCC(NCCNC(=O)c2cccs2)CC1	nan
	CHEMBL1367424	27317	None	9	Human	Functional	pEC50	=	4.3	4.3	-3	4	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	325	6	2	5	1.7	CCOC(=O)N1CCC(NCCNC(=O)c2cccs2)CC1	nan
	187	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	137639541	156701	None	0	Human	Functional	pEC50	=	4.3	4.3	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4070061	156701	None	0	Human	Functional	pEC50	=	4.3	4.3	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	42598358	16100	None	0	Human	Functional	pEC50	=	6.3	6.3	-501	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223860	16100	None	0	Human	Functional	pEC50	=	6.3	6.3	-501	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	187	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	187	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44303293	201424	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60479	201424	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	53382542	86311	None	0	Human	Functional	pEC50	=	6.3	6.3	-7	6	Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assayPositive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	CHEMBL2313377	86311	None	0	Human	Functional	pEC50	=	6.3	6.3	-7	6	Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assayPositive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	187	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	122191005	123612	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	5	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618447	123612	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	5	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	2551	793	None	23	Human	Functional	pEC50	=	4.2	4.2	-2	13	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	298	793	None	23	Human	Functional	pEC50	=	4.2	4.2	-2	13	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	488	793	None	23	Human	Functional	pEC50	=	4.2	4.2	-2	13	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	CHEMBL965	793	None	23	Human	Functional	pEC50	=	4.2	4.2	-2	13	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	DB00411	793	None	23	Human	Functional	pEC50	=	4.2	4.2	-2	13	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	10426487	2839	None	7	Human	Functional	pEC50	=	7.2	7.2	-3	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	291	2839	None	7	Human	Functional	pEC50	=	7.2	7.2	-3	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	CHEMBL99521	2839	None	7	Human	Functional	pEC50	=	7.2	7.2	-3	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	306	3454	None	21	Human	Functional	pEC50	=	7.2	7.2	-1	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	3536	3454	None	21	Human	Functional	pEC50	=	7.2	7.2	-1	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	53930639	3454	None	21	Human	Functional	pEC50	=	7.2	7.2	-1	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	9577995	3454	None	21	Human	Functional	pEC50	=	7.2	7.2	-1	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	CHEMBL134641	3454	None	21	Human	Functional	pEC50	=	7.2	7.2	-1	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	42598591	16075	None	0	Human	Functional	pEC50	=	7.2	7.2	-125	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	384	5	0	3	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223803	16075	None	0	Human	Functional	pEC50	=	7.2	7.2	-125	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	384	5	0	3	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42599068	16077	None	0	Human	Functional	pEC50	=	6.2	6.2	-199	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	356	3	0	3	3.7	CO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223805	16077	None	0	Human	Functional	pEC50	=	6.2	6.2	-199	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	356	3	0	3	3.7	CO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	25230693	16123	None	0	Human	Functional	pEC50	=	6.2	6.2	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	402	6	0	6	3.9	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223940	16123	None	0	Human	Functional	pEC50	=	6.2	6.2	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	402	6	0	6	3.9	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	16071018	16052	None	20	Human	Functional	pEC50	=	6.2	6.2	-112	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	CHEMBL1223753	16052	None	20	Human	Functional	pEC50	=	6.2	6.2	-112	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	16038385	80456	None	0	Human	Functional	pEC50	=	6.2	6.2	-10	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	301	2	1	4	2.1	O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	CHEMBL2146598	80456	None	0	Human	Functional	pEC50	=	6.2	6.2	-10	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	301	2	1	4	2.1	O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	16123945	80457	None	12	Human	Functional	pEC50	=	6.2	6.2	-125	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	315	2	1	4	2.5	Cc1ccc2[nH]c(=O)n(C3CCN(C4CCOCC4)CC3)c2c1	10.1021/ml100105x
	CHEMBL2146599	80457	None	12	Human	Functional	pEC50	=	6.2	6.2	-125	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	315	2	1	4	2.5	Cc1ccc2[nH]c(=O)n(C3CCN(C4CCOCC4)CC3)c2c1	10.1021/ml100105x
	170332	160974	None	1	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	2166	3121	None	49	Human	Functional	pEC50	=	4.2	4.2	-28	10	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	305	3121	None	49	Human	Functional	pEC50	=	4.2	4.2	-28	10	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	5910	3121	None	49	Human	Functional	pEC50	=	4.2	4.2	-28	10	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	CHEMBL550	3121	None	49	Human	Functional	pEC50	=	4.2	4.2	-28	10	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	DB01085	3121	None	49	Human	Functional	pEC50	=	4.2	4.2	-28	10	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	170332	160974	None	1	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	122189495	123333	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	445	5	2	3	4.7	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616499	123333	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	445	5	2	3	4.7	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	122191008	123615	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	465	5	2	3	5.0	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618450	123615	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	465	5	2	3	5.0	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	44303397	102286	None	0	Human	Functional	pEC50	=	6.2	6.2	-75	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL303360	102286	None	0	Human	Functional	pEC50	=	6.2	6.2	-75	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10104047	21635	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21635	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	10019339	102624	None	0	Human	Functional	pEC50	=	6.2	6.2	-138	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL304247	102624	None	0	Human	Functional	pEC50	=	6.2	6.2	-138	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	5441	2424	None	10	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	9893054	2424	None	10	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	CHEMBL3616501	2424	None	10	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	187	255	None	39	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	294	255	None	39	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	65	255	None	39	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	8593	255	None	39	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	CHEMBL667	255	None	39	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	DB03128	255	None	39	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	2551	793	None	23	Human	Functional	pEC50	=	6.2	6.2	-2	13	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	298	793	None	23	Human	Functional	pEC50	=	6.2	6.2	-2	13	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	488	793	None	23	Human	Functional	pEC50	=	6.2	6.2	-2	13	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	CHEMBL965	793	None	23	Human	Functional	pEC50	=	6.2	6.2	-2	13	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	DB00411	793	None	23	Human	Functional	pEC50	=	6.2	6.2	-2	13	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	2551	793	None	23	Human	Functional	pEC50	=	6.2	6.2	-2	13	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	298	793	None	23	Human	Functional	pEC50	=	6.2	6.2	-2	13	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	488	793	None	23	Human	Functional	pEC50	=	6.2	6.2	-2	13	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	CHEMBL965	793	None	23	Human	Functional	pEC50	=	6.2	6.2	-2	13	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	DB00411	793	None	23	Human	Functional	pEC50	=	6.2	6.2	-2	13	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	59654579	123605	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618440	123605	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	122190994	123602	None	0	Human	Functional	pEC50	=	6.1	6.1	-14	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	481	4	3	3	5.1	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)Nc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618436	123602	None	0	Human	Functional	pEC50	=	6.1	6.1	-14	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	481	4	3	3	5.1	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)Nc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	44303294	201154	None	0	Human	Functional	pEC50	=	6.1	6.1	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60331	201154	None	0	Human	Functional	pEC50	=	6.1	6.1	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	170332	160974	None	1	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44303286	201316	None	0	Human	Functional	pEC50	=	6.1	6.1	-48	3	Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL60419	201316	None	0	Human	Functional	pEC50	=	6.1	6.1	-48	3	Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	44303286	201316	None	0	Human	Functional	pEC50	=	6.1	6.1	-48	3	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1016/s0960-894x(98)00509-5
	CHEMBL60419	201316	None	0	Human	Functional	pEC50	=	6.1	6.1	-48	3	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1016/s0960-894x(98)00509-5
	170332	160974	None	1	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44253016	80455	None	2	Human	Functional	pEC50	=	7.1	7.1	-6	4	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	299	2	1	3	3.3	O=c1[nH]c2ccccc2n1C1CCN(C2CCCCC2)CC1	10.1021/ml100105x
	CHEMBL2146597	80455	None	2	Human	Functional	pEC50	=	7.1	7.1	-6	4	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	299	2	1	3	3.3	O=c1[nH]c2ccccc2n1C1CCN(C2CCCCC2)CC1	10.1021/ml100105x
	44303019	100944	None	0	Human	Functional	pEC50	=	6.1	6.1	-79	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL294082	100944	None	0	Human	Functional	pEC50	=	6.1	6.1	-79	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	16071018	16052	None	20	Human	Functional	pEC50	=	6.1	6.1	-112	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223753	16052	None	20	Human	Functional	pEC50	=	6.1	6.1	-112	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1016/j.bmcl.2010.07.097
	42598828	16101	None	0	Human	Functional	pEC50	=	6.1	6.1	-630	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4c(F)cc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223861	16101	None	0	Human	Functional	pEC50	=	6.1	6.1	-630	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4c(F)cc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42599071	16122	None	0	Human	Functional	pEC50	=	6.1	6.1	-316	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	450	6	0	7	3.8	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223939	16122	None	0	Human	Functional	pEC50	=	6.1	6.1	-316	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	450	6	0	7	3.8	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	9883040	100535	None	0	Human	Functional	pEC50	=	8.1	8.1	-7	3	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL291339	100535	None	0	Human	Functional	pEC50	=	8.1	8.1	-7	3	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL542622	100535	None	0	Human	Functional	pEC50	=	8.1	8.1	-7	3	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	44303396	201234	None	0	Human	Functional	pEC50	=	7.1	7.1	1	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60374	201234	None	0	Human	Functional	pEC50	=	7.1	7.1	1	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	118500	156997	None	63	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4073256	156997	None	63	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	44303323	163240	None	0	Human	Functional	pEC50	=	7.1	7.1	-18	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL418491	163240	None	0	Human	Functional	pEC50	=	7.1	7.1	-18	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	10104047	21635	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21635	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	71792	78404	None	38	Human	Functional	pEC50	=	6.1	6.1	-2	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	165	2	0	2	0.7	C#CCO[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.08.011
	CHEMBL2111051	78404	None	38	Human	Functional	pEC50	=	6.1	6.1	-2	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	165	2	0	2	0.7	C#CCO[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.08.011
	44303327	163009	None	0	Human	Functional	pEC50	=	6.1	6.1	-31	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL417560	163009	None	0	Human	Functional	pEC50	=	6.1	6.1	-31	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	2551	793	None	23	Human	Functional	pEC50	=	6.1	6.1	-2	13	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	298	793	None	23	Human	Functional	pEC50	=	6.1	6.1	-2	13	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	488	793	None	23	Human	Functional	pEC50	=	6.1	6.1	-2	13	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL965	793	None	23	Human	Functional	pEC50	=	6.1	6.1	-2	13	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB00411	793	None	23	Human	Functional	pEC50	=	6.1	6.1	-2	13	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44330081	208161	None	0	Human	Functional	pEC50	=	8.1	8.1	-17	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL98255	208161	None	0	Human	Functional	pEC50	=	8.1	8.1	-17	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44303314	100931	None	0	Human	Functional	pEC50	=	6.0	6.0	-363	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL293982	100931	None	0	Human	Functional	pEC50	=	6.0	6.0	-363	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137629744	161173	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4071109	161173	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117602	161173	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	644390	40410	None	6	Human	Functional	pEC50	=	4.0	4.0	-3	4	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	353	6	2	4	2.3	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2Cl)CC1	nan
	CHEMBL1482157	40410	None	6	Human	Functional	pEC50	=	4.0	4.0	-3	4	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	353	6	2	4	2.3	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2Cl)CC1	nan
	25010776	55953	None	2	Human	Functional	pEC50	=	4.0	4.0	-44	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	CHEMBL1559151	55953	None	2	Human	Functional	pEC50	=	4.0	4.0	-44	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	CHEMBL1624037	55953	None	2	Human	Functional	pEC50	=	4.0	4.0	-44	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	137646732	157790	None	0	Human	Functional	pEC50	=	6.0	6.0	-12	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	422	3	2	7	2.9	Cc1nnc2sc(C(=O)NC3CN(c4ccc(C(F)(F)F)nc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4083081	157790	None	0	Human	Functional	pEC50	=	6.0	6.0	-12	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	422	3	2	7	2.9	Cc1nnc2sc(C(=O)NC3CN(c4ccc(C(F)(F)F)nc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	75356563	156955	None	23	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	CHEMBL4072787	156955	None	23	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	44372610	52541	None	0	Human	Functional	pED50	=	9.1	9.1	181	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	CHEMBL159208	52541	None	0	Human	Functional	pED50	=	9.1	9.1	181	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	44372301	49800	None	0	Human	Functional	pED50	=	8.7	8.7	40	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	CHEMBL156749	49800	None	0	Human	Functional	pED50	=	8.7	8.7	40	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	44372633	50306	None	0	Human	Functional	pED50	=	8.0	8.0	-1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	CHEMBL157197	50306	None	0	Human	Functional	pED50	=	8.0	8.0	-1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	44372232	119818	None	0	Human	Functional	pED50	=	8.0	8.0	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL348412	119818	None	0	Human	Functional	pED50	=	8.0	8.0	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	10058744	206380	None	0	Human	Functional	pED50	=	8.0	8.0	1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL87622	206380	None	0	Human	Functional	pED50	=	8.0	8.0	1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372253	50008	None	0	Human	Functional	pED50	=	7.9	7.9	21	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL156925	50008	None	0	Human	Functional	pED50	=	7.9	7.9	21	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	9795428	96486	None	5	Human	Functional	pED50	=	5.9	5.9	-30	5	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CC[C@@H]2C3)c1	10.1021/jm960683m
	CHEMBL262455	96486	None	5	Human	Functional	pED50	=	5.9	5.9	-30	5	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CC[C@@H]2C3)c1	10.1021/jm960683m
	5487543	205644	None	4	Human	Functional	pED50	=	5.9	5.9	-162	6	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL81878	205644	None	4	Human	Functional	pED50	=	5.9	5.9	-162	6	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	10266025	120164	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL351561	120164	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372580	119779	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL348079	119779	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372492	155722	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	314	3	0	3	3.3	C/C(C#Cc1ccc(Cl)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL405426	155722	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	314	3	0	3	3.3	C/C(C#Cc1ccc(Cl)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	2551	793	None	23	Human	Functional	pED50	=	7.6	7.6	-2	13	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	298	793	None	23	Human	Functional	pED50	=	7.6	7.6	-2	13	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	488	793	None	23	Human	Functional	pED50	=	7.6	7.6	-2	13	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	CHEMBL965	793	None	23	Human	Functional	pED50	=	7.6	7.6	-2	13	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	DB00411	793	None	23	Human	Functional	pED50	=	7.6	7.6	-2	13	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	10420458	206266	None	0	Human	Functional	pED50	=	7.6	7.6	7	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL86903	206266	None	0	Human	Functional	pED50	=	7.6	7.6	7	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372591	54343	None	0	Human	Functional	pED50	=	7.6	7.6	-60	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL160858	54343	None	0	Human	Functional	pED50	=	7.6	7.6	-60	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372290	54449	None	0	Human	Functional	pED50	=	6.6	6.6	-5	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL160939	54449	None	0	Human	Functional	pED50	=	6.6	6.6	-5	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	2551	793	None	23	Human	Functional	pED50	=	6.6	6.6	-2	13	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	298	793	None	23	Human	Functional	pED50	=	6.6	6.6	-2	13	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	488	793	None	23	Human	Functional	pED50	=	6.6	6.6	-2	13	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	CHEMBL965	793	None	23	Human	Functional	pED50	=	6.6	6.6	-2	13	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	DB00411	793	None	23	Human	Functional	pED50	=	6.6	6.6	-2	13	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	44372254	53964	None	0	Human	Functional	pED50	=	7.6	7.6	-	1	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL160554	53964	None	0	Human	Functional	pED50	=	7.6	7.6	-	1	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	10086044	48976	None	0	Human	Functional	pED50	=	8.5	8.5	6	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL156050	48976	None	0	Human	Functional	pED50	=	8.5	8.5	6	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	9903828	119491	None	0	Human	Functional	pED50	=	8.4	8.4	28	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345415	119491	None	0	Human	Functional	pED50	=	8.4	8.4	28	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372506	119467	None	0	Human	Functional	pED50	=	8.4	8.4	19	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345205	119467	None	0	Human	Functional	pED50	=	8.4	8.4	19	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372278	49408	None	0	Human	Functional	pED50	=	8.4	8.4	11	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL156445	49408	None	0	Human	Functional	pED50	=	8.4	8.4	11	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	44372277	168361	None	0	Human	Functional	pED50	=	7.4	7.4	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL434469	168361	None	0	Human	Functional	pED50	=	7.4	7.4	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	10242016	168297	None	0	Human	Functional	pED50	=	7.4	7.4	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL434072	168297	None	0	Human	Functional	pED50	=	7.4	7.4	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372289	119474	None	0	Human	Functional	pED50	=	6.3	6.3	-2	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345250	119474	None	0	Human	Functional	pED50	=	6.3	6.3	-2	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44213237	101919	None	0	Human	Functional	pED50	=	6.2	6.2	-	0	Effective dose against affinity towards human muscarinic M2 receptorEffective dose against affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL300998	101919	None	0	Human	Functional	pED50	=	6.2	6.2	-	0	Effective dose against affinity towards human muscarinic M2 receptorEffective dose against affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	44372647	120018	None	0	Human	Functional	pED50	=	8.1	8.1	-1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	CHEMBL350223	120018	None	0	Human	Functional	pED50	=	8.1	8.1	-1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	44371814	51397	None	0	Human	Functional	pED50	=	8.0	8.0	3	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL158180	51397	None	0	Human	Functional	pED50	=	8.0	8.0	3	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372452	119621	None	0	Human	Functional	pED50	=	6.0	6.0	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	348	3	0	3	4.0	C/C(C#Cc1ccc(Cl)c(Cl)c1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL346580	119621	None	0	Human	Functional	pED50	=	6.0	6.0	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	348	3	0	3	4.0	C/C(C#Cc1ccc(Cl)c(Cl)c1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	9913341	82156	None	4	Human	Functional	pIC50	=	9.3	9.3	28	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL216927	82156	None	4	Human	Functional	pIC50	=	9.3	9.3	28	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL553058	82156	None	4	Human	Functional	pIC50	=	9.3	9.3	28	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	44590172	170316	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL444688	170316	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL527216	170316	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590171	178746	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL468609	178746	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL554632	178746	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590176	189063	None	0	Human	Functional	pIC50	=	8	8.0	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL509614	189063	None	0	Human	Functional	pIC50	=	8	8.0	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555707	189063	None	0	Human	Functional	pIC50	=	8	8.0	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	155566290	176578	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176578	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176578	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	11690968	106499	None	0	Human	Functional	pIC50	=	8.0	8.0	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085072	106499	None	0	Human	Functional	pIC50	=	8.0	8.0	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140185	106499	None	0	Human	Functional	pIC50	=	8.0	8.0	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	44590179	172715	None	0	Human	Functional	pIC50	=	7	7.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450538	172715	None	0	Human	Functional	pIC50	=	7	7.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553446	172715	None	0	Human	Functional	pIC50	=	7	7.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590167	179022	None	0	Human	Functional	pIC50	=	7	7.0	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	494	10	4	6	2.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL471214	179022	None	0	Human	Functional	pIC50	=	7	7.0	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	494	10	4	6	2.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589495	185978	None	0	Human	Functional	pIC50	=	7	7.0	-10	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	5	7	3.8	CCCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL486982	185978	None	0	Human	Functional	pIC50	=	7	7.0	-10	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	5	7	3.8	CCCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590122	192558	None	0	Human	Functional	pIC50	=	7	7.0	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	555	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C#N)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL521244	192558	None	0	Human	Functional	pIC50	=	7	7.0	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	555	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C#N)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16125400	84661	None	0	Human	Functional	pIC50	=	6	6.0	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222449	84661	None	0	Human	Functional	pIC50	=	6	6.0	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	76313456	106507	None	0	Human	Functional	pIC50	=	6	6.0	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085066	106507	None	0	Human	Functional	pIC50	=	6	6.0	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140216	106507	None	0	Human	Functional	pIC50	=	6	6.0	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	162675053	183256	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4796491	183256	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	71455968	83924	None	0	Human	Functional	pIC50	=	7.0	7.0	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206599	83924	None	0	Human	Functional	pIC50	=	7.0	7.0	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	10397133	107060	None	1	Human	Functional	pIC50	=	6.0	6.0	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL315676	107060	None	1	Human	Functional	pIC50	=	6.0	6.0	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71716773	86564	None	0	Rat	Functional	pIC50	=	6.0	6.0	2	2	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL2315680	86564	None	0	Rat	Functional	pIC50	=	6.0	6.0	2	2	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	162353372	181385	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4763422	181385	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	71463135	83932	None	0	Human	Functional	pIC50	=	7.0	7.0	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	607	12	4	5	5.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206607	83932	None	0	Human	Functional	pIC50	=	7.0	7.0	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	607	12	4	5	5.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1	10.1016/j.bmcl.2012.09.085
	71716773	86564	None	0	Rat	Functional	pIC50	=	6.0	6.0	2	2	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL2315680	86564	None	0	Rat	Functional	pIC50	=	6.0	6.0	2	2	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	109018479	181816	None	1	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	CHEMBL4778178	181816	None	1	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	76327901	103493	None	0	Human	Functional	pIC50	=	5.9	5.9	1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085084	103493	None	0	Human	Functional	pIC50	=	5.9	5.9	1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	44233675	103376	None	0	Human	Functional	pIC50	=	5.9	5.9	-11	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	381	5	0	1	6.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084639	103376	None	0	Human	Functional	pIC50	=	5.9	5.9	-11	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	381	5	0	1	6.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	11518068	106504	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085059	106504	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140213	106504	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	44590180	172644	None	0	Human	Functional	pIC50	=	7.9	7.9	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL449640	172644	None	0	Human	Functional	pIC50	=	7.9	7.9	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540398	172644	None	0	Human	Functional	pIC50	=	7.9	7.9	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590175	188630	None	0	Human	Functional	pIC50	=	7.9	7.9	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL503025	188630	None	0	Human	Functional	pIC50	=	7.9	7.9	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553433	188630	None	0	Human	Functional	pIC50	=	7.9	7.9	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	52176747	159029	None	1	Human	Functional	pIC50	=	5.9	5.9	-2	8	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	CHEMBL4096727	159029	None	1	Human	Functional	pIC50	=	5.9	5.9	-2	8	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	162353379	180960	None	0	Human	Functional	pIC50	=	4.9	4.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4758449	180960	None	0	Human	Functional	pIC50	=	4.9	4.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	25034111	193416	None	0	Human	Functional	pIC50	=	6.9	6.9	-7	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL526009	193416	None	0	Human	Functional	pIC50	=	6.9	6.9	-7	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44590123	183858	None	0	Human	Functional	pIC50	=	6.9	6.9	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	564	10	4	6	4.3	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(Cl)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480877	183858	None	0	Human	Functional	pIC50	=	6.9	6.9	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	564	10	4	6	4.3	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(Cl)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034111	193416	None	0	Human	Functional	pIC50	=	6.9	6.9	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL526009	193416	None	0	Human	Functional	pIC50	=	6.9	6.9	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589497	175291	None	0	Human	Functional	pIC50	=	5.9	5.9	-5	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	11	5	7	4.0	CC(C)COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL457302	175291	None	0	Human	Functional	pIC50	=	5.9	5.9	-5	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	11	5	7	4.0	CC(C)COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44233417	86044	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	467	8	2	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2307674	86044	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	467	8	2	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10092649	193071	None	56	Rat	Functional	pIC50	=	5.9	5.9	-16	11	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193071	None	56	Rat	Functional	pIC50	=	5.9	5.9	-16	11	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	10092649	193071	None	56	Rat	Functional	pIC50	=	5.9	5.9	-16	11	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193071	None	56	Rat	Functional	pIC50	=	5.9	5.9	-16	11	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	290	2471	None	6	Human	Functional	pIC50	=	4.9	4.9	-21	5	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	4022	2471	None	6	Human	Functional	pIC50	=	4.9	4.9	-21	5	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	5926	2471	None	6	Human	Functional	pIC50	=	4.9	4.9	-21	5	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	CHEMBL40554	2471	None	6	Human	Functional	pIC50	=	4.9	4.9	-21	5	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	CHEMBL74300	2471	None	6	Human	Functional	pIC50	=	4.9	4.9	-21	5	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	71450616	83931	None	0	Human	Functional	pIC50	=	7.9	7.9	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	591	11	4	5	4.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206606	83931	None	0	Human	Functional	pIC50	=	7.9	7.9	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	591	11	4	5	4.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1	10.1016/j.bmcl.2012.09.085
	11503336	106512	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085071	106512	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140242	106512	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	76309756	103492	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	375	4	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085083	103492	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	375	4	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	76313457	103489	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085080	103489	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	13940563	206028	None	5	Rat	Functional	pIC50	=	5.9	5.9	5	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	182	2	0	3	-0.3	CN(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL8510	206028	None	5	Rat	Functional	pIC50	=	5.9	5.9	5	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	182	2	0	3	-0.3	CN(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	162353393	179437	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	CHEMBL4740422	179437	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	16664965	84900	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL223668	84900	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	76320693	103491	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085082	103491	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	109035013	180473	None	1	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	CHEMBL4752973	180473	None	1	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	76309755	103487	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085079	103487	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	76320692	106506	None	0	Human	Functional	pIC50	=	5.8	5.8	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085065	106506	None	0	Human	Functional	pIC50	=	5.8	5.8	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140215	106506	None	0	Human	Functional	pIC50	=	5.8	5.8	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71459691	83930	None	0	Human	Functional	pIC50	=	7.8	7.8	5	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	14	4	5	8.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc3ccccc3c2)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206605	83930	None	0	Human	Functional	pIC50	=	7.8	7.8	5	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	14	4	5	8.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc3ccccc3c2)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	44590170	188369	None	0	Human	Functional	pIC50	=	7.8	7.8	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL501348	188369	None	0	Human	Functional	pIC50	=	7.8	7.8	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553431	188369	None	0	Human	Functional	pIC50	=	7.8	7.8	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	109032820	182873	None	1	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4791819	182873	None	1	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	162353369	180793	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756442	180793	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	44232953	103389	None	0	Human	Functional	pIC50	=	5.8	5.8	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	405	7	2	2	4.6	CCNC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	CHEMBL3084663	103389	None	0	Human	Functional	pIC50	=	5.8	5.8	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	405	7	2	2	4.6	CCNC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	15681301	120318	None	0	Human	Functional	pIC50	=	4.8	4.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	3	0	3	0.7	C#CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL352832	120318	None	0	Human	Functional	pIC50	=	4.8	4.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	3	0	3	0.7	C#CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	15945874	188763	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL505452	188763	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	15945874	188763	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL505452	188763	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589984	190556	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL518001	190556	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590035	191752	None	0	Human	Functional	pIC50	=	6.8	6.8	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3OC)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL519760	191752	None	0	Human	Functional	pIC50	=	6.8	6.8	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3OC)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034180	188410	None	0	Human	Functional	pIC50	=	5.8	5.8	1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL502000	188410	None	0	Human	Functional	pIC50	=	5.8	5.8	1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44589571	172585	None	0	Human	Functional	pIC50	=	5.8	5.8	-10	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	580	11	5	6	3.5	N#Cc1ccc(CN2CCC(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)NCC4CC4)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448904	172585	None	0	Human	Functional	pIC50	=	5.8	5.8	-10	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	580	11	5	6	3.5	N#Cc1ccc(CN2CCC(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)NCC4CC4)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589570	172755	None	0	Human	Functional	pIC50	=	5.8	5.8	-15	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	568	10	5	6	3.5	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(C#N)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL451040	172755	None	0	Human	Functional	pIC50	=	5.8	5.8	-15	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	568	10	5	6	3.5	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(C#N)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	10465524	58994	None	0	Human	Functional	pIC50	=	4.8	4.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	204	3	0	3	1.3	C=CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL169011	58994	None	0	Human	Functional	pIC50	=	4.8	4.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	204	3	0	3	1.3	C=CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	137630050	161038	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	137408729	190740	None	0	Human	Functional	pIC50	=	5.8	5.8	-870	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	444	6	1	5	4.9	Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5182783	190740	None	0	Human	Functional	pIC50	=	5.8	5.8	-870	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	444	6	1	5	4.9	Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	15681299	120477	None	0	Human	Functional	pIC50	=	5.8	5.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	2	0	3	1.2	C1CC(O/N=C2\CN3CCC2C3)C1	10.1016/S0960-894X(00)80538-7
	CHEMBL354259	120477	None	0	Human	Functional	pIC50	=	5.8	5.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	2	0	3	1.2	C1CC(O/N=C2\CN3CCC2C3)C1	10.1016/S0960-894X(00)80538-7
	156015978	178321	None	0	Human	Functional	pIC50	=	7.8	7.8	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178321	None	0	Human	Functional	pIC50	=	7.8	7.8	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178321	None	0	Human	Functional	pIC50	=	7.8	7.8	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	10397356	120714	None	0	Human	Functional	pIC50	=	5.8	5.8	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	CC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL354738	120714	None	0	Human	Functional	pIC50	=	5.8	5.8	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	CC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	137630050	161038	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	162353388	180977	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4758633	180977	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	71459689	83914	None	0	Human	Functional	pIC50	=	6.8	6.8	1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	595	13	4	5	5.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206585	83914	None	0	Human	Functional	pIC50	=	6.8	6.8	1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	595	13	4	5	5.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	168276820	190104	None	0	Human	Functional	pIC50	=	5.8	5.8	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5172967	190104	None	0	Human	Functional	pIC50	=	5.8	5.8	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5208649	190104	None	0	Human	Functional	pIC50	=	5.8	5.8	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	71454215	83923	None	0	Human	Functional	pIC50	=	6.7	6.7	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	714	13	4	6	6.5	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCc2n(Cc3ccc(Cl)cc3)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206595	83923	None	0	Human	Functional	pIC50	=	6.7	6.7	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	714	13	4	6	6.5	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCc2n(Cc3ccc(Cl)cc3)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	109013312	180132	None	1	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4748774	180132	None	1	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	162658112	181069	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4759774	181069	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	11602980	103500	None	0	Human	Functional	pIC50	=	7.7	7.7	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	5	4.6	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085091	103500	None	0	Human	Functional	pIC50	=	7.7	7.7	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	5	4.6	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	76324336	103495	None	0	Human	Functional	pIC50	=	6.7	6.7	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085086	103495	None	0	Human	Functional	pIC50	=	6.7	6.7	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	162353384	181088	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4760037	181088	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	71452455	83917	None	0	Human	Functional	pIC50	=	6.7	6.7	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	565	9	3	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206588	83917	None	0	Human	Functional	pIC50	=	6.7	6.7	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	565	9	3	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	44590125	183859	None	0	Human	Functional	pIC50	=	6.7	6.7	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	530	10	4	6	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480878	183859	None	0	Human	Functional	pIC50	=	6.7	6.7	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	530	10	4	6	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590036	188375	None	0	Human	Functional	pIC50	=	6.7	6.7	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	10	4	8	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL501419	188375	None	0	Human	Functional	pIC50	=	6.7	6.7	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	10	4	8	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	152278786	182750	None	1	Human	Functional	pIC50	=	6.7	6.7	-117	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	CHEMBL4790083	182750	None	1	Human	Functional	pIC50	=	6.7	6.7	-117	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	162646559	179638	None	0	Human	Functional	pIC50	=	5.7	5.7	-154	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@@H](C)C1	10.1021/acsmedchemlett.0c00626
	CHEMBL4742997	179638	None	0	Human	Functional	pIC50	=	5.7	5.7	-154	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@@H](C)C1	10.1021/acsmedchemlett.0c00626
	25034112	188391	None	0	Human	Functional	pIC50	=	4.7	4.7	-1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL501727	188391	None	0	Human	Functional	pIC50	=	4.7	4.7	-1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44589585	188890	None	0	Human	Functional	pIC50	=	8.6	8.6	-1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL507375	188890	None	0	Human	Functional	pIC50	=	8.6	8.6	-1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555474	188890	None	0	Human	Functional	pIC50	=	8.6	8.6	-1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590177	188920	None	0	Human	Functional	pIC50	=	8.6	8.6	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL507874	188920	None	0	Human	Functional	pIC50	=	8.6	8.6	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL554918	188920	None	0	Human	Functional	pIC50	=	8.6	8.6	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	163938	106916	None	13	Human	Functional	pIC50	=	7.7	7.7	316	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	1	1	5	0.1	Nc1noc(C2CN3CCC2C3)n1	10.1016/S0960-894X(00)80538-7
	CHEMBL314737	106916	None	13	Human	Functional	pIC50	=	7.7	7.7	316	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	1	1	5	0.1	Nc1noc(C2CN3CCC2C3)n1	10.1016/S0960-894X(00)80538-7
	152278786	182750	None	1	Human	Functional	pIC50	=	6.7	6.7	-117	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	CHEMBL4790083	182750	None	1	Human	Functional	pIC50	=	6.7	6.7	-117	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	162353375	179893	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4745885	179893	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	10262405	57594	None	0	Human	Functional	pIC50	=	4.7	4.7	-2	2	Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsCompound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	206	3	0	3	1.5	CCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166782	57594	None	0	Human	Functional	pIC50	=	4.7	4.7	-2	2	Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsCompound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	206	3	0	3	1.5	CCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44234194	103394	None	0	Human	Functional	pIC50	=	5.7	5.7	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	412	7	1	3	3.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084670	103394	None	0	Human	Functional	pIC50	=	5.7	5.7	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	412	7	1	3	3.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10262466	98342	None	0	Rat	Functional	pIC50	=	6.7	6.7	-10	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL275104	98342	None	0	Rat	Functional	pIC50	=	6.7	6.7	-10	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	76324335	103490	None	0	Human	Functional	pIC50	=	5.7	5.7	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085081	103490	None	0	Human	Functional	pIC50	=	5.7	5.7	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	10399393	205784	None	0	Human	Functional	pIC50	=	5.7	5.7	1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL83074	205784	None	0	Human	Functional	pIC50	=	5.7	5.7	1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	162658421	181099	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4760150	181099	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	156015807	178297	None	0	Human	Functional	pIC50	=	6.7	6.7	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178297	None	0	Human	Functional	pIC50	=	6.7	6.7	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178297	None	0	Human	Functional	pIC50	=	6.7	6.7	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	76324334	106475	None	0	Human	Functional	pIC50	=	6.6	6.6	-15	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085070	106475	None	0	Human	Functional	pIC50	=	6.6	6.6	-15	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140112	106475	None	0	Human	Functional	pIC50	=	6.6	6.6	-15	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	156015978	178321	None	0	Human	Functional	pIC50	=	7.6	7.6	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178321	None	0	Human	Functional	pIC50	=	7.6	7.6	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178321	None	0	Human	Functional	pIC50	=	7.6	7.6	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	138578683	184801	None	0	Human	Functional	pIC50	=	5.6	5.6	-1318	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1	10.1021/acsmedchemlett.1c00363
	CHEMBL4851711	184801	None	0	Human	Functional	pIC50	=	5.6	5.6	-1318	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1	10.1021/acsmedchemlett.1c00363
	44265375	206145	None	0	Rat	Functional	pIC50	=	6.6	6.6	-3	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL8610	206145	None	0	Rat	Functional	pIC50	=	6.6	6.6	-3	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	162353386	180978	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758635	180978	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	44233189	103399	None	0	Human	Functional	pIC50	=	6.6	6.6	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	349	5	1	2	4.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084678	103399	None	0	Human	Functional	pIC50	=	6.6	6.6	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	349	5	1	2	4.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	162667844	182531	None	0	Human	Functional	pIC50	=	4.6	4.6	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4787283	182531	None	0	Human	Functional	pIC50	=	4.6	4.6	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	44418764	82157	None	0	Human	Functional	pIC50	=	6.6	6.6	-1	4	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	CHEMBL216928	82157	None	0	Human	Functional	pIC50	=	6.6	6.6	-1	4	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	44590033	183676	None	0	Human	Functional	pIC50	=	6.6	6.6	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(OC)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480299	183676	None	0	Human	Functional	pIC50	=	6.6	6.6	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(OC)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590166	189414	None	0	Human	Functional	pIC50	=	5.6	5.6	-3	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	468	9	4	6	2.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL513228	189414	None	0	Human	Functional	pIC50	=	5.6	5.6	-3	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	468	9	4	6	2.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC)C2)cc1	10.1016/j.bmcl.2008.09.020
	76316970	103484	None	0	Human	Functional	pIC50	=	6.6	6.6	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	350	4	0	3	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085076	103484	None	0	Human	Functional	pIC50	=	6.6	6.6	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	350	4	0	3	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	10220392	206003	None	0	Human	Functional	pIC50	=	4.6	4.6	-6	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL84893	206003	None	0	Human	Functional	pIC50	=	4.6	4.6	-6	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	11508710	103498	None	0	Human	Functional	pIC50	=	7.6	7.6	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085089	103498	None	0	Human	Functional	pIC50	=	7.6	7.6	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	156493644	185060	None	0	Human	Functional	pIC50	=	5.6	5.6	-1737	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	435	6	2	6	3.7	CC(=O)Nc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4855467	185060	None	0	Human	Functional	pIC50	=	5.6	5.6	-1737	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	435	6	2	6	3.7	CC(=O)Nc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	156493614	185398	None	0	Human	Functional	pIC50	=	5.6	5.6	-338	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4860985	185398	None	0	Human	Functional	pIC50	=	5.6	5.6	-338	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	168272462	190162	None	0	Human	Functional	pIC50	=	5.6	5.6	-51	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	428	6	1	5	4.4	Fc1ccc(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5173887	190162	None	0	Human	Functional	pIC50	=	5.6	5.6	-51	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	428	6	1	5	4.4	Fc1ccc(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	137630050	161038	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	46830362	7892	None	0	Human	Functional	pIC50	=	5.6	5.6	-5	5	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	479	4	1	3	5.8	CCN1CCN(c2ccc(NC(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	CHEMBL1090097	7892	None	0	Human	Functional	pIC50	=	5.6	5.6	-5	5	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	479	4	1	3	5.8	CCN1CCN(c2ccc(NC(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	76331543	103501	None	0	Human	Functional	pIC50	=	6.6	6.6	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	4	4.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085092	103501	None	0	Human	Functional	pIC50	=	6.6	6.6	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	4	4.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	138578326	186226	None	0	Human	Functional	pIC50	=	6.6	6.6	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4861863	186226	None	0	Human	Functional	pIC50	=	6.6	6.6	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873386	186226	None	0	Human	Functional	pIC50	=	6.6	6.6	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	9990434	106337	None	0	Human	Functional	pIC50	=	5.6	5.6	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL313918	106337	None	0	Human	Functional	pIC50	=	5.6	5.6	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44455159	97763	None	0	Rat	Functional	pIC50	=	4.5	4.5	-25	5	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	383	5	1	3	4.2	CCN1CCN(c2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL271704	97763	None	0	Rat	Functional	pIC50	=	4.5	4.5	-25	5	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	383	5	1	3	4.2	CCN1CCN(c2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	46682613	181154	None	1	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760823	181154	None	1	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	162353378	182909	None	0	Human	Functional	pIC50	=	4.5	4.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4792360	182909	None	0	Human	Functional	pIC50	=	4.5	4.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	44590174	170055	None	0	Human	Functional	pIC50	=	8.4	8.4	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL444300	170055	None	0	Human	Functional	pIC50	=	8.4	8.4	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL466271	170055	None	0	Human	Functional	pIC50	=	8.4	8.4	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590178	172736	None	0	Human	Functional	pIC50	=	8.4	8.4	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450781	172736	None	0	Human	Functional	pIC50	=	8.4	8.4	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540400	172736	None	0	Human	Functional	pIC50	=	8.4	8.4	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	11583262	106495	None	0	Human	Functional	pIC50	=	7.5	7.5	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085060	106495	None	0	Human	Functional	pIC50	=	7.5	7.5	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140181	106495	None	0	Human	Functional	pIC50	=	7.5	7.5	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156493565	184984	None	0	Human	Functional	pIC50	=	5.5	5.5	-1318	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1cccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4854289	184984	None	0	Human	Functional	pIC50	=	5.5	5.5	-1318	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1cccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	168276820	190104	None	0	Human	Functional	pIC50	=	5.5	5.5	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5172967	190104	None	0	Human	Functional	pIC50	=	5.5	5.5	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5208649	190104	None	0	Human	Functional	pIC50	=	5.5	5.5	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	10058347	105929	None	0	Human	Functional	pIC50	=	4.5	4.5	-2	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL312823	105929	None	0	Human	Functional	pIC50	=	4.5	4.5	-2	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71450615	83929	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	609	14	4	5	5.5	CC[N+](CC)(CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)OC(C)C)cc1)Cc1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206604	83929	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	609	14	4	5	5.5	CC[N+](CC)(CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)OC(C)C)cc1)Cc1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.085
	11819427	57550	None	0	Human	Functional	pIC50	=	5.5	5.5	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	2	0	3	1.1	CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166423	57550	None	0	Human	Functional	pIC50	=	5.5	5.5	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	2	0	3	1.1	CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	47358375	180760	None	1	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756164	180760	None	1	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	11584660	93266	None	8	Human	Functional	pIC50	=	6.5	6.5	-1	5	Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL244946	93266	None	8	Human	Functional	pIC50	=	6.5	6.5	-1	5	Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	44590182	183149	None	0	Human	Functional	pIC50	=	6.5	6.5	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	532	9	5	7	3.0	COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL479526	183149	None	0	Human	Functional	pIC50	=	6.5	6.5	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	532	9	5	7	3.0	COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590034	189975	None	0	Human	Functional	pIC50	=	6.5	6.5	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(OC)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL517087	189975	None	0	Human	Functional	pIC50	=	6.5	6.5	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(OC)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16094791	83255	None	0	Human	Functional	pIC50	=	5.5	5.5	-3	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL218755	83255	None	0	Human	Functional	pIC50	=	5.5	5.5	-3	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	162353374	180041	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4747590	180041	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	138578970	185665	None	0	Human	Functional	pIC50	=	5.5	5.5	-1862	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	414	5	1	5	4.0	Fc1ccc(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4864914	185665	None	0	Human	Functional	pIC50	=	5.5	5.5	-1862	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	414	5	1	5	4.0	Fc1ccc(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	71452456	83934	None	0	Human	Functional	pIC50	=	6.5	6.5	-2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	525	10	4	5	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(C)CCCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206609	83934	None	0	Human	Functional	pIC50	=	6.5	6.5	-2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	525	10	4	5	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(C)CCCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	122203596	155804	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	137637944	155813	None	0	Human	Functional	pIC50	=	6.5	6.5	-3	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	450	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4059829	155813	None	0	Human	Functional	pIC50	=	6.5	6.5	-3	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	450	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	71450617	83935	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	527	12	4	5	4.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206610	83935	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	527	12	4	5	4.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2012.09.085
	162353382	181732	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	CHEMBL4777127	181732	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	11626847	106474	None	0	Human	Functional	pIC50	=	7.5	7.5	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085068	106474	None	0	Human	Functional	pIC50	=	7.5	7.5	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140111	106474	None	0	Human	Functional	pIC50	=	7.5	7.5	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	2551	793	None	23	Human	Functional	pIC50	=	5.5	5.5	-2	13	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	298	793	None	23	Human	Functional	pIC50	=	5.5	5.5	-2	13	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	488	793	None	23	Human	Functional	pIC50	=	5.5	5.5	-2	13	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	CHEMBL965	793	None	23	Human	Functional	pIC50	=	5.5	5.5	-2	13	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	DB00411	793	None	23	Human	Functional	pIC50	=	5.5	5.5	-2	13	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	10092649	193071	None	56	Human	Functional	pIC50	=	5.5	5.5	-43	11	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193071	None	56	Human	Functional	pIC50	=	5.5	5.5	-43	11	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	44233419	103397	None	0	Human	Functional	pIC50	=	5.5	5.5	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	376	6	1	2	4.4	CC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	CHEMBL3084674	103397	None	0	Human	Functional	pIC50	=	5.5	5.5	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	376	6	1	2	4.4	CC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	10092649	193071	None	56	Human	Functional	pIC50	=	5.5	5.5	-43	11	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193071	None	56	Human	Functional	pIC50	=	5.5	5.5	-43	11	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	164606754	184700	None	7	Human	Functional	pIC50	=	5.5	5.5	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4850236	184700	None	7	Human	Functional	pIC50	=	5.5	5.5	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873617	184700	None	7	Human	Functional	pIC50	=	5.5	5.5	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	138578253	186453	None	0	Human	Functional	pIC50	=	5.5	5.5	-1230	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	378	5	1	5	3.7	c1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4876599	186453	None	0	Human	Functional	pIC50	=	5.5	5.5	-1230	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	378	5	1	5	3.7	c1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	24882532	95115	None	0	Rat	Functional	pIC50	=	5.5	5.5	-7	4	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255523	95115	None	0	Rat	Functional	pIC50	=	5.5	5.5	-7	4	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	137638270	156875	None	0	Human	Functional	pIC50	=	6.5	6.5	-3	5	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	434	4	0	8	2.2	Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC(C)(C)C3)nn2)CC1	10.1016/j.bmcl.2017.05.042
	CHEMBL4071900	156875	None	0	Human	Functional	pIC50	=	6.5	6.5	-3	5	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	434	4	0	8	2.2	Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC(C)(C)C3)nn2)CC1	10.1016/j.bmcl.2017.05.042
	137647734	157844	None	0	Human	Functional	pIC50	=	6.5	6.5	-2	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	448	4	0	5	4.7	O=C(C1CCN(c2cc(Oc3ccc(Cl)cc3)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4083681	157844	None	0	Human	Functional	pIC50	=	6.5	6.5	-2	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	448	4	0	5	4.7	O=C(C1CCN(c2cc(Oc3ccc(Cl)cc3)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	156016041	178245	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178245	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178245	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	122203596	155804	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	76327903	103502	None	0	Human	Functional	pIC50	=	6.4	6.4	-4	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	381	4	0	5	4.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085093	103502	None	0	Human	Functional	pIC50	=	6.4	6.4	-4	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	381	4	0	5	4.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	69444105	103485	None	0	Human	Functional	pIC50	=	7.4	7.4	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085077	103485	None	0	Human	Functional	pIC50	=	7.4	7.4	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156015807	178297	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178297	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178297	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	137655063	158971	None	0	Human	Functional	pIC50	=	6.4	6.4	-3	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	432	4	0	5	4.2	O=C(C1CCN(c2cc(Oc3ccccc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4096143	158971	None	0	Human	Functional	pIC50	=	6.4	6.4	-3	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	432	4	0	5	4.2	O=C(C1CCN(c2cc(Oc3ccccc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	11552174	103499	None	0	Human	Functional	pIC50	=	7.4	7.4	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085090	103499	None	0	Human	Functional	pIC50	=	7.4	7.4	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	44589583	172479	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448294	172479	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555471	172479	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590168	172727	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450652	172727	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540399	172727	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589584	188777	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL505651	188777	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540144	188777	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16094788	141913	None	0	Human	Functional	pIC50	=	6.4	6.4	-1	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL386983	141913	None	0	Human	Functional	pIC50	=	6.4	6.4	-1	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	162353381	180027	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4747438	180027	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	44589498	172756	None	0	Human	Functional	pIC50	=	6.4	6.4	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	572	11	5	7	3.8	O=C(Nc1ccc(C(=O)OCC2CC2)cc1)N[C@@H](Cc1ccc(O)cc1)C(=O)NC1CCN(Cc2ccc(O)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL451043	172756	None	0	Human	Functional	pIC50	=	6.4	6.4	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	572	11	5	7	3.8	O=C(Nc1ccc(C(=O)OCC2CC2)cc1)N[C@@H](Cc1ccc(O)cc1)C(=O)NC1CCN(Cc2ccc(O)cc2)C1	10.1016/j.bmcl.2008.09.020
	10419574	58093	None	0	Human	Functional	pIC50	=	5.4	5.4	2	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	3	0	3	1.1	CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL167438	58093	None	0	Human	Functional	pIC50	=	5.4	5.4	2	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	3	0	3	1.1	CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	76327900	106481	None	0	Human	Functional	pIC50	=	6.4	6.4	-12	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085061	106481	None	0	Human	Functional	pIC50	=	6.4	6.4	-12	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140142	106481	None	0	Human	Functional	pIC50	=	6.4	6.4	-12	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71457771	83927	None	0	Human	Functional	pIC50	=	6.4	6.4	-5	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	691	14	4	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc(Cl)cc2)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206602	83927	None	0	Human	Functional	pIC50	=	6.4	6.4	-5	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	691	14	4	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc(Cl)cc2)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	76320694	103494	None	0	Human	Functional	pIC50	=	6.4	6.4	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085085	103494	None	0	Human	Functional	pIC50	=	6.4	6.4	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	71454213	83920	None	0	Human	Functional	pIC50	=	7.4	7.4	11	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	11	3	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCc4ccccc4C3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206591	83920	None	0	Human	Functional	pIC50	=	7.4	7.4	11	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	11	3	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCc4ccccc4C3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	71450662	84004	None	0	Human	Functional	pIC50	=	6.4	6.4	1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	611	13	4	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2207176	84004	None	0	Human	Functional	pIC50	=	6.4	6.4	1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	611	13	4	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	162649767	180100	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4748337	180100	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	71452454	83916	None	0	Human	Functional	pIC50	=	6.4	6.4	-41	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	603	9	3	7	3.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(Cc3ccc4c(c3)OCO4)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206587	83916	None	0	Human	Functional	pIC50	=	6.4	6.4	-41	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	603	9	3	7	3.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(Cc3ccc4c(c3)OCO4)CC2)cc1	10.1016/j.bmcl.2012.09.085
	54816802	181270	None	2	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4762056	181270	None	2	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	10081053	57568	None	0	Human	Functional	pIC50	=	5.4	5.4	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	182	1	0	3	1.5	CC(C)(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166593	57568	None	0	Human	Functional	pIC50	=	5.4	5.4	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	182	1	0	3	1.5	CC(C)(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44233187	86023	None	0	Human	Functional	pIC50	=	6.3	6.3	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	474	8	1	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2306159	86023	None	0	Human	Functional	pIC50	=	6.3	6.3	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	474	8	1	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	76327902	103497	None	0	Human	Functional	pIC50	=	6.3	6.3	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	354	4	0	4	4.4	Cc1ccoc1CN(C(=O)O[C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085088	103497	None	0	Human	Functional	pIC50	=	6.3	6.3	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	354	4	0	4	4.4	Cc1ccoc1CN(C(=O)O[C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	164606754	184700	None	7	Human	Functional	pIC50	=	5.3	5.3	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4850236	184700	None	7	Human	Functional	pIC50	=	5.3	5.3	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873617	184700	None	7	Human	Functional	pIC50	=	5.3	5.3	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	109035056	181321	None	1	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	CHEMBL4762755	181321	None	1	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	11619198	106489	None	0	Human	Functional	pIC50	=	7.3	7.3	-10	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085058	106489	None	0	Human	Functional	pIC50	=	7.3	7.3	-10	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140170	106489	None	0	Human	Functional	pIC50	=	7.3	7.3	-10	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156015153	178305	None	0	Human	Functional	pIC50	=	7.3	7.3	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178305	None	0	Human	Functional	pIC50	=	7.3	7.3	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178305	None	0	Human	Functional	pIC50	=	7.3	7.3	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162353371	181648	None	0	Human	Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4775999	181648	None	0	Human	Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	16040727	169441	None	0	Human	Functional	pIC50	=	8.3	8.3	2	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL442672	169441	None	0	Human	Functional	pIC50	=	8.3	8.3	2	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL495102	169441	None	0	Human	Functional	pIC50	=	8.3	8.3	2	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590169	188241	None	0	Human	Functional	pIC50	=	8.3	8.3	7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL499565	188241	None	0	Human	Functional	pIC50	=	8.3	8.3	7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL539885	188241	None	0	Human	Functional	pIC50	=	8.3	8.3	7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590181	173562	None	0	Human	Functional	pIC50	=	7.3	7.3	12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL453248	173562	None	0	Human	Functional	pIC50	=	7.3	7.3	12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL551113	173562	None	0	Human	Functional	pIC50	=	7.3	7.3	12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034110	188764	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL505453	188764	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	10376012	58731	None	0	Human	Functional	pIC50	=	5.3	5.3	1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	216	2	0	3	1.1	CC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168561	58731	None	0	Human	Functional	pIC50	=	5.3	5.3	1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	216	2	0	3	1.1	CC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	76320690	106458	None	0	Human	Functional	pIC50	=	6.3	6.3	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085063	106458	None	0	Human	Functional	pIC50	=	6.3	6.3	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140092	106458	None	0	Human	Functional	pIC50	=	6.3	6.3	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	137654353	159014	None	0	Human	Functional	pIC50	=	6.3	6.3	-1	6	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	436	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1Cc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4096589	159014	None	0	Human	Functional	pIC50	=	6.3	6.3	-1	6	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	436	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1Cc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	2986945	95053	None	7	Rat	Functional	pIC50	=	4.3	4.3	-47	5	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	371	6	1	3	4.1	CCN1CCN(c2ccc(NC(=O)CCc3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255169	95053	None	7	Rat	Functional	pIC50	=	4.3	4.3	-47	5	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	371	6	1	3	4.1	CCN1CCN(c2ccc(NC(=O)CCc3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	2904292	183578	None	13	Human	Functional	pIC50	=	4.3	4.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4800495	183578	None	13	Human	Functional	pIC50	=	4.3	4.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	15681300	57561	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	C#CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166537	57561	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	C#CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	11510358	106482	None	0	Human	Functional	pIC50	=	7.3	7.3	-4	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085069	106482	None	0	Human	Functional	pIC50	=	7.3	7.3	-4	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140143	106482	None	0	Human	Functional	pIC50	=	7.3	7.3	-4	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	58975257	103375	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	377	6	2	2	3.9	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(N)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084638	103375	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	377	6	2	2	3.9	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(N)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	36014865	182668	None	2	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	CHEMBL4789054	182668	None	2	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	44233928	86072	None	0	Human	Functional	pIC50	=	6.3	6.3	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	438	7	1	2	5.6	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2308786	86072	None	0	Human	Functional	pIC50	=	6.3	6.3	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	438	7	1	2	5.6	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	71455969	83928	None	0	Human	Functional	pIC50	=	6.3	6.3	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	581	12	4	5	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206603	83928	None	0	Human	Functional	pIC50	=	6.3	6.3	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	581	12	4	5	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	11547053	106463	None	0	Human	Functional	pIC50	=	7.3	7.3	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085074	106463	None	0	Human	Functional	pIC50	=	7.3	7.3	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140097	106463	None	0	Human	Functional	pIC50	=	7.3	7.3	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	71454217	83926	None	0	Human	Functional	pIC50	=	6.3	6.3	1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	551	9	3	5	4.3	CC[N+]1(C2CCN(C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)CC2)CCCC1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206601	83926	None	0	Human	Functional	pIC50	=	6.3	6.3	1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	551	9	3	5	4.3	CC[N+]1(C2CCN(C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)CC2)CCCC1	10.1016/j.bmcl.2012.09.085
	109014373	179800	None	1	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4744856	179800	None	1	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	156016041	178245	None	0	Human	Functional	pIC50	=	7.2	7.2	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178245	None	0	Human	Functional	pIC50	=	7.2	7.2	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178245	None	0	Human	Functional	pIC50	=	7.2	7.2	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	71455966	83919	None	0	Human	Functional	pIC50	=	7.2	7.2	2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	675	11	3	5	6.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206590	83919	None	0	Human	Functional	pIC50	=	7.2	7.2	2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	675	11	3	5	6.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	52176747	159029	None	1	Rat	Functional	pIC50	=	5.2	5.2	-13	8	Antagonist activity at rat muscarinic M2 receptor by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	CHEMBL4096727	159029	None	1	Rat	Functional	pIC50	=	5.2	5.2	-13	8	Antagonist activity at rat muscarinic M2 receptor by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	15681303	58988	None	0	Human	Functional	pIC50	=	4.2	4.2	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	208	3	0	4	0.3	COCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168991	58988	None	0	Human	Functional	pIC50	=	4.2	4.2	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	208	3	0	4	0.3	COCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44590173	189089	None	0	Human	Functional	pIC50	=	8.2	8.2	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL510029	189089	None	0	Human	Functional	pIC50	=	8.2	8.2	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555019	189089	None	0	Human	Functional	pIC50	=	8.2	8.2	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	156015153	178305	None	0	Human	Functional	pIC50	=	7.2	7.2	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178305	None	0	Human	Functional	pIC50	=	7.2	7.2	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178305	None	0	Human	Functional	pIC50	=	7.2	7.2	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	11712408	106520	None	0	Human	Functional	pIC50	=	7.2	7.2	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085067	106520	None	0	Human	Functional	pIC50	=	7.2	7.2	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140261	106520	None	0	Human	Functional	pIC50	=	7.2	7.2	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	108993425	181756	None	1	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4777543	181756	None	1	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	168289751	191808	None	0	Human	Functional	pIC50	=	5.2	5.2	-47	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	7	4.0	Cn1cc2cc(-c3ccc(NC[C@@H]4CC45CCN(CC4CCOCC4)CC5)nn3)ccc2n1	10.1016/j.bmcl.2021.128479
	CHEMBL5198423	191808	None	0	Human	Functional	pIC50	=	5.2	5.2	-47	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	7	4.0	Cn1cc2cc(-c3ccc(NC[C@@H]4CC45CCN(CC4CCOCC4)CC5)nn3)ccc2n1	10.1016/j.bmcl.2021.128479
	2551	793	None	23	Human	Functional	pIC50	=	7.2	7.2	-2	13	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	298	793	None	23	Human	Functional	pIC50	=	7.2	7.2	-2	13	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	488	793	None	23	Human	Functional	pIC50	=	7.2	7.2	-2	13	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	CHEMBL965	793	None	23	Human	Functional	pIC50	=	7.2	7.2	-2	13	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	DB00411	793	None	23	Human	Functional	pIC50	=	7.2	7.2	-2	13	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	1201549	596	None	24	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	333	596	None	24	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	7601	596	None	24	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	CHEMBL1201203	596	None	24	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	CHEMBL438151	596	None	24	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	DB00245	596	None	24	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	44590124	169792	None	0	Human	Functional	pIC50	=	6.2	6.2	-39	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	4	6	4.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C(F)(F)F)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL443925	169792	None	0	Human	Functional	pIC50	=	6.2	6.2	-39	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	4	6	4.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C(F)(F)F)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	162657046	180841	None	0	Human	Functional	pIC50	=	6.2	6.2	-99	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1	10.1021/acsmedchemlett.0c00626
	CHEMBL4757103	180841	None	0	Human	Functional	pIC50	=	6.2	6.2	-99	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1	10.1021/acsmedchemlett.0c00626
	76316969	106521	None	0	Human	Functional	pIC50	=	6.2	6.2	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085075	106521	None	0	Human	Functional	pIC50	=	6.2	6.2	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140262	106521	None	0	Human	Functional	pIC50	=	6.2	6.2	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	162353391	180819	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	CHEMBL4756873	180819	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	76313454	106505	None	0	Human	Functional	pIC50	=	6.2	6.2	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085064	106505	None	0	Human	Functional	pIC50	=	6.2	6.2	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140214	106505	None	0	Human	Functional	pIC50	=	6.2	6.2	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	138578326	186226	None	0	Human	Functional	pIC50	=	6.2	6.2	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4861863	186226	None	0	Human	Functional	pIC50	=	6.2	6.2	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873386	186226	None	0	Human	Functional	pIC50	=	6.2	6.2	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	76309754	106519	None	0	Human	Functional	pIC50	=	6.2	6.2	-8	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085062	106519	None	0	Human	Functional	pIC50	=	6.2	6.2	-8	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140260	106519	None	0	Human	Functional	pIC50	=	6.2	6.2	-8	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	1421986	8263	None	4	Human	Functional	pIC50	=	5.2	5.2	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	357	4	1	3	4.0	CCN1CCN(c2ccc(NC(=O)c3ccc(C)cc3)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	CHEMBL1092461	8263	None	4	Human	Functional	pIC50	=	5.2	5.2	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	357	4	1	3	4.0	CCN1CCN(c2ccc(NC(=O)c3ccc(C)cc3)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	11442478	106476	None	0	Human	Functional	pIC50	=	8.1	8.1	-7	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085073	106476	None	0	Human	Functional	pIC50	=	8.1	8.1	-7	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140113	106476	None	0	Human	Functional	pIC50	=	8.1	8.1	-7	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	10109893	82163	None	0	Human	Functional	pIC50	=	8.1	8.1	89	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL216983	82163	None	0	Human	Functional	pIC50	=	8.1	8.1	89	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL544840	82163	None	0	Human	Functional	pIC50	=	8.1	8.1	89	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	162353376	180425	None	0	Human	Functional	pIC50	=	4.2	4.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4752380	180425	None	0	Human	Functional	pIC50	=	4.2	4.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	11820032	98222	None	0	Rat	Functional	pIC50	=	7.1	7.1	1	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL274329	98222	None	0	Rat	Functional	pIC50	=	7.1	7.1	1	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	162353377	181163	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760904	181163	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	162353390	180947	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4758316	180947	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	162670602	182935	None	0	Human	Functional	pIC50	=	4.1	4.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4792675	182935	None	0	Human	Functional	pIC50	=	4.1	4.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	133640439	181371	None	1	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4763304	181371	None	1	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	10240891	206096	None	0	Human	Functional	pIC50	=	5.1	5.1	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL85678	206096	None	0	Human	Functional	pIC50	=	5.1	5.1	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	16094783	136565	None	0	Human	Functional	pIC50	=	7.1	7.1	12	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL373888	136565	None	0	Human	Functional	pIC50	=	7.1	7.1	12	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	44589496	185979	None	0	Human	Functional	pIC50	=	7.1	7.1	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	10	5	7	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL486983	185979	None	0	Human	Functional	pIC50	=	7.1	7.1	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	10	5	7	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	174174	523	None	49	Human	Functional	pIC50	=	8.1	8.1	-6	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	523	None	49	Human	Functional	pIC50	=	8.1	8.1	-6	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	523	None	49	Human	Functional	pIC50	=	8.1	8.1	-6	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	523	None	49	Human	Functional	pIC50	=	8.1	8.1	-6	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	523	None	49	Human	Functional	pIC50	=	8.1	8.1	-6	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	174174	523	None	49	Human	Functional	pIC50	=	8.1	8.1	-6	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	260	523	None	49	Human	Functional	pIC50	=	8.1	8.1	-6	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	320	523	None	49	Human	Functional	pIC50	=	8.1	8.1	-6	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	CHEMBL517712	523	None	49	Human	Functional	pIC50	=	8.1	8.1	-6	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	DB00572	523	None	49	Human	Functional	pIC50	=	8.1	8.1	-6	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	76309757	103496	None	0	Human	Functional	pIC50	=	7.1	7.1	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	340	4	0	4	4.0	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085087	103496	None	0	Human	Functional	pIC50	=	7.1	7.1	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	340	4	0	4	4.0	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71463136	83933	None	0	Human	Functional	pIC50	=	7.1	7.1	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	12	4	5	5.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206608	83933	None	0	Human	Functional	pIC50	=	7.1	7.1	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	12	4	5	5.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	71459724	84005	None	0	Human	Functional	pIC50	=	6.1	6.1	-63	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2207177	84005	None	0	Human	Functional	pIC50	=	6.1	6.1	-63	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	302	2975	None	25	Rat	Functional	pIC50	=	7.1	7.1	-7	8	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	4630	2975	None	25	Rat	Functional	pIC50	=	7.1	7.1	-7	8	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL7634	2975	None	25	Rat	Functional	pIC50	=	7.1	7.1	-7	8	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	122203596	155804	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	71454214	83921	None	0	Human	Functional	pIC50	=	6.1	6.1	1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	573	10	3	5	4.2	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CCc3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206592	83921	None	0	Human	Functional	pIC50	=	6.1	6.1	1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	573	10	3	5	4.2	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CCc3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	10375322	58728	None	0	Human	Functional	pIC50	=	5.1	5.1	-1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	192	2	0	3	1.1	CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168545	58728	None	0	Human	Functional	pIC50	=	5.1	5.1	-1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	192	2	0	3	1.1	CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71454212	83915	None	0	Human	Functional	pIC50	=	7.1	7.1	5	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	623	13	4	5	5.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC(C)(C)C[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206586	83915	None	0	Human	Functional	pIC50	=	7.1	7.1	5	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	623	13	4	5	5.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC(C)(C)C[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	16125704	84662	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222450	84662	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL4755618	214039	None	39	Human	Functional	pIC50	=	5.1	5.1	1	2	Agonist activity at muscarinic M2 receptor (unknown origin)Agonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL		None	None	None		Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12	10.1021/acs.jmedchem.1c02148
	11617374	103486	None	0	Human	Functional	pIC50	=	7.0	7.0	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085078	103486	None	0	Human	Functional	pIC50	=	7.0	7.0	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	155522355	176407	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176407	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176407	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	49665121	170461	None	11	Human	Functional	pIC50	=	6.0	6.0	3	3	Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseAntagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium response	ChEMBL	384	4	0	8	3.4	Fc1cc(F)cc(-c2nnc(Cc3nc(-c4ccc5c(c4)OCO5)no3)o2)c1	10.1016/j.bmcl.2016.07.071
	CHEMBL4448840	170461	None	11	Human	Functional	pIC50	=	6.0	6.0	3	3	Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseAntagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium response	ChEMBL	384	4	0	8	3.4	Fc1cc(F)cc(-c2nnc(Cc3nc(-c4ccc5c(c4)OCO5)no3)o2)c1	10.1016/j.bmcl.2016.07.071
	162353387	181229	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4761549	181229	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	71457770	83925	None	0	Human	Functional	pIC50	=	7.0	7.0	-1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	647	10	3	5	6.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC([N+]3(Cc4ccc(Cl)cc4)CCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206600	83925	None	0	Human	Functional	pIC50	=	7.0	7.0	-1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	647	10	3	5	6.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC([N+]3(Cc4ccc(Cl)cc4)CCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	10376182	58754	None	0	Human	Functional	pIC50	=	5.0	5.0	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	220	4	0	3	1.9	CCCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168639	58754	None	0	Human	Functional	pIC50	=	5.0	5.0	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	220	4	0	3	1.9	CCCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71455965	83918	None	0	Human	Functional	pIC50	=	7.0	7.0	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(C(C)C)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206589	83918	None	0	Human	Functional	pIC50	=	7.0	7.0	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(C(C)C)CC2)cc1	10.1016/j.bmcl.2012.09.085
	162353383	182575	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	CHEMBL4787944	182575	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	162657652	180983	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758742	180983	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	71463134	83922	None	0	Human	Functional	pIC50	=	6	6.0	-2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	618	11	3	6	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N(C)Cc2n(C)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206594	83922	None	0	Human	Functional	pIC50	=	6	6.0	-2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	618	11	3	6	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N(C)Cc2n(C)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	11519069	3937	None	3	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	11519070	3937	None	3	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	4816	3937	None	3	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	7354	3937	None	3	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	CHEMBL1187833	3937	None	3	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	DB09076	3937	None	3	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	25195533	78384	None	2	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2103803	78384	None	2	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2110584	78384	None	2	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589580	173146	None	0	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL452142	173146	None	0	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL553448	173146	None	0	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	132947	3862	None	9	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	361	3862	None	9	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	CHEMBL265256	3862	None	9	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	132947	3862	None	9	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	361	3862	None	9	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	CHEMBL265256	3862	None	9	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	25034186	201436	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL540396	201436	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL604842	201436	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	44589579	189052	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	CHEMBL509515	189052	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	CHEMBL540148	189052	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	11766733	155752	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202003	155752	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL405739	155752	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	132947	3862	None	9	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	361	3862	None	9	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	CHEMBL265256	3862	None	9	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	10770914	25059	None	0	Human	Functional	pKd	=	9.5	9.5	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL134692	25059	None	0	Human	Functional	pKd	=	9.5	9.5	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44232952	103381	None	0	Human	Functional	pKd	=	9.5	9.5	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084650	103381	None	0	Human	Functional	pKd	=	9.5	9.5	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10580398	21609	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	677	24	3	7	6.0	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL131748	21609	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	677	24	3	7	6.0	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	23724781	2833	None	19	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	316	2833	None	19	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	317	2833	None	19	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	71183	2833	None	19	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL1354199	2833	None	19	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL3140030	2833	None	19	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL376897	2833	None	19	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	DB00462	2833	None	19	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	23724781	2833	None	19	Human	Functional	pKd	=	9.3	9.3	-138	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	316	2833	None	19	Human	Functional	pKd	=	9.3	9.3	-138	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	317	2833	None	19	Human	Functional	pKd	=	9.3	9.3	-138	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	71183	2833	None	19	Human	Functional	pKd	=	9.3	9.3	-138	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL1354199	2833	None	19	Human	Functional	pKd	=	9.3	9.3	-138	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL3140030	2833	None	19	Human	Functional	pKd	=	9.3	9.3	-138	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL376897	2833	None	19	Human	Functional	pKd	=	9.3	9.3	-138	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	DB00462	2833	None	19	Human	Functional	pKd	=	9.3	9.3	-138	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	10109130	133013	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL370232	133013	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10291366	140697	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381623	140697	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	69058946	106473	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084658	106473	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140110	106473	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10629559	23749	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	25	4	10	7.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL133561	23749	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	25	4	10	7.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	10628017	21714	None	0	Human	Functional	pKd	=	9.2	9.2	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL131865	21714	None	0	Human	Functional	pKd	=	9.2	9.2	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	14939891	169362	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL442014	169362	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	14939891	169362	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00075a032
	CHEMBL442014	169362	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00075a032
	9946298	72825	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200171	72825	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406481	72873	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200319	72873	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406573	72972	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200693	72972	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10532418	24603	None	0	Human	Functional	pKd	=	9.0	9.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	664	27	3	7	7.4	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL134294	24603	None	0	Human	Functional	pKd	=	9.0	9.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	664	27	3	7	7.4	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	25034182	172582	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL448870	172582	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL540359	172582	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	25034182	172582	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448870	172582	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540359	172582	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16116085	11844	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1182201	11844	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL219786	11844	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	12872437	12056	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL1183585	12056	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL306182	12056	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	11691950	12760	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL1187853	12760	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL524097	12760	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	174174	523	None	49	Human	Functional	pKd	=	8.9	8.9	-6	7	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	260	523	None	49	Human	Functional	pKd	=	8.9	8.9	-6	7	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	320	523	None	49	Human	Functional	pKd	=	8.9	8.9	-6	7	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	CHEMBL517712	523	None	49	Human	Functional	pKd	=	8.9	8.9	-6	7	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	DB00572	523	None	49	Human	Functional	pKd	=	8.9	8.9	-6	7	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	10771937	21691	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202004	21691	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL131846	21691	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	25034184	188395	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL501803	188395	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL539887	188395	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	44589581	188786	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL505751	188786	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL540145	188786	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	14939896	82085	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201996	82085	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216566	82085	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44406686	140909	None	0	Human	Functional	pKd	=	8.7	8.7	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL382213	140909	None	0	Human	Functional	pKd	=	8.7	8.7	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	174174	523	None	49	Human	Functional	pKd	=	8.7	8.7	-6	7	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	260	523	None	49	Human	Functional	pKd	=	8.7	8.7	-6	7	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	320	523	None	49	Human	Functional	pKd	=	8.7	8.7	-6	7	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	CHEMBL517712	523	None	49	Human	Functional	pKd	=	8.7	8.7	-6	7	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	DB00572	523	None	49	Human	Functional	pKd	=	8.7	8.7	-6	7	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	44341782	9991	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL114885	9991	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	44318928	205761	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	CHEMBL82859	205761	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	44319043	206057	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85391	206057	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11753447	187349	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	459	7	2	4	4.4	CC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	CHEMBL493265	187349	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	459	7	2	4	4.4	CC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	2166	3121	None	49	Rat	Functional	pKd	=	5	5.0	-131	10	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	305	3121	None	49	Rat	Functional	pKd	=	5	5.0	-131	10	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	5910	3121	None	49	Rat	Functional	pKd	=	5	5.0	-131	10	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL550	3121	None	49	Rat	Functional	pKd	=	5	5.0	-131	10	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	DB01085	3121	None	49	Rat	Functional	pKd	=	5	5.0	-131	10	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	128222	102086	None	6	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL302179	102086	None	6	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	44341878	110338	None	0	Human	Functional	pKd	=	6.0	6.0	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	674	13	2	8	5.8	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL324026	110338	None	0	Human	Functional	pKd	=	6.0	6.0	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	674	13	2	8	5.8	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	14939893	9532	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL112244	9532	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	154734599	2501	None	12	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	327	2501	None	12	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	4108	2501	None	12	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL27673	2501	None	12	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	154734599	2501	None	12	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	327	2501	None	12	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	4108	2501	None	12	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	CHEMBL27673	2501	None	12	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	44319071	206017	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL84993	206017	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11556983	187363	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL493331	187363	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL538864	187363	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL555476	187363	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	44341782	9991	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL114885	9991	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	44341782	9991	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL114885	9991	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	10789183	104365	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL310132	104365	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44318782	206131	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85996	206131	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44380974	57563	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	558	27	4	4	7.5	Fc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(F)cc2)cc1	10.1021/jm00121a017
	CHEMBL166544	57563	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	558	27	4	4	7.5	Fc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(F)cc2)cc1	10.1021/jm00121a017
	101720828	97118	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	16147087	97118	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202002	97118	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL267643	97118	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	44381057	58110	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	651	34	4	5	9.9	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	CHEMBL167587	58110	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	651	34	4	5	9.9	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	44380592	59308	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(OC)cc2)cc1	10.1021/jm00121a017
	CHEMBL170554	59308	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(OC)cc2)cc1	10.1021/jm00121a017
	154734599	2501	None	12	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	327	2501	None	12	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	4108	2501	None	12	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL27673	2501	None	12	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	154734599	2501	None	12	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	327	2501	None	12	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	4108	2501	None	12	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL27673	2501	None	12	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	101676031	97326	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	16175987	97326	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201998	97326	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL269272	97326	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	319	1323	None	44	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	321	1323	None	44	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	444031	1323	None	44	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	784	1323	None	44	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	CHEMBL1346	1323	None	44	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	DB00496	1323	None	44	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	2705	3840	None	64	Human	Functional	pKd	=	7.8	7.8	-1	9	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	360	3840	None	64	Human	Functional	pKd	=	7.8	7.8	-1	9	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	443879	3840	None	64	Human	Functional	pKd	=	7.8	7.8	-1	9	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	CHEMBL1382	3840	None	64	Human	Functional	pKd	=	7.8	7.8	-1	9	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	DB01036	3840	None	64	Human	Functional	pKd	=	7.8	7.8	-1	9	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	44380973	120729	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(OC)c2)c1	10.1021/jm00121a017
	CHEMBL354855	120729	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(OC)c2)c1	10.1021/jm00121a017
	44319342	205716	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL82512	205716	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319339	205905	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83982	205905	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44341864	109209	None	0	Human	Functional	pKd	=	5.8	5.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	575	7	2	7	4.7	CCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL321687	109209	None	0	Human	Functional	pKd	=	5.8	5.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	575	7	2	7	4.7	CCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44380309	58774	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168736	58774	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	44298537	101040	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	639	29	0	6	8.6	COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	CHEMBL294613	101040	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	639	29	0	6	8.6	COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	44380837	58438	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)cc2)cc1	10.1021/jm00121a017
	CHEMBL168304	58438	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)cc2)cc1	10.1021/jm00121a017
	44381064	58259	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168235	58259	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	10316726	12026	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	12026	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	12026	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	16144765	96877	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1403	29	4	16	11.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL265592	96877	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1403	29	4	16	11.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	44380612	59190	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(Cl)cc2)cc1	10.1021/jm00121a017
	CHEMBL170113	59190	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(Cl)cc2)cc1	10.1021/jm00121a017
	44341975	9526	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	543	14	1	6	5.7	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC	10.1021/jm00046a021
	CHEMBL112208	9526	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	543	14	1	6	5.7	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC	10.1021/jm00046a021
	44380613	58493	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(Cl)c2)c1	10.1021/jm00121a017
	CHEMBL168322	58493	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(Cl)c2)c1	10.1021/jm00121a017
	154734599	2501	None	12	Human	Functional	pKd	=	7.7	7.7	47	5	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	327	2501	None	12	Human	Functional	pKd	=	7.7	7.7	47	5	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	4108	2501	None	12	Human	Functional	pKd	=	7.7	7.7	47	5	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL27673	2501	None	12	Human	Functional	pKd	=	7.7	7.7	47	5	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	10049361	206119	None	0	Human	Functional	pKd	=	7.7	7.7	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85892	206119	None	0	Human	Functional	pKd	=	7.7	7.7	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	9913892	205835	None	0	Human	Functional	pKd	=	5.7	5.7	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83459	205835	None	0	Human	Functional	pKd	=	5.7	5.7	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	14537191	147987	None	0	Human	Functional	pKd	=	5.7	5.7	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL39342	147987	None	0	Human	Functional	pKd	=	5.7	5.7	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	10486393	141700	None	0	Human	Functional	pKd	=	8.6	8.6	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202000	141700	None	0	Human	Functional	pKd	=	8.6	8.6	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL385625	141700	None	0	Human	Functional	pKd	=	8.6	8.6	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10794142	22934	None	0	Human	Functional	pKd	=	8.6	8.6	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	635	25	3	7	6.6	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL132926	22934	None	0	Human	Functional	pKd	=	8.6	8.6	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	635	25	3	7	6.6	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	1734	116	None	10	Human	Functional	pKd	=	8.6	8.6	-97	6	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	307	116	None	10	Human	Functional	pKd	=	8.6	8.6	-97	6	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	CHEMBL168067	116	None	10	Human	Functional	pKd	=	8.6	8.6	-97	6	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	16086059	80773	None	0	Rat	Functional	pKd	=	6.7	6.7	-	0	Antagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atriaAntagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atria	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL215180	80773	None	0	Rat	Functional	pKd	=	6.7	6.7	-	0	Antagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atriaAntagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atria	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	10722780	22297	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	638	27	2	6	7.0	COc1ccccc1CNCCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL132377	22297	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	638	27	2	6	7.0	COc1ccccc1CNCCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	44355098	24701	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	540	26	4	6	6.1	COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL134382	24701	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	540	26	4	6	6.1	COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	44355099	165249	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	568	28	4	6	6.8	COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL422977	165249	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	568	28	4	6	6.8	COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	11365314	187350	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	473	8	2	4	4.8	CCC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	CHEMBL493266	187350	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	473	8	2	4	4.8	CCC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	44341764	9952	None	0	Human	Functional	pKd	=	6.6	6.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	423	11	2	5	3.8	CCN(CC)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL114681	9952	None	0	Human	Functional	pKd	=	6.6	6.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	423	11	2	5	3.8	CCN(CC)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10402105	110489	None	0	Human	Functional	pKd	=	5.6	5.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	292	12	1	3	3.7	CCN(CC)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL324855	110489	None	0	Human	Functional	pKd	=	5.6	5.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	292	12	1	3	3.7	CCN(CC)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	14211056	107161	None	0	Rat	Functional	pKd	=	5.6	5.6	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL316309	107161	None	0	Rat	Functional	pKd	=	5.6	5.6	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44380611	58822	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	614	29	4	6	8.7	CSc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1SC	10.1021/jm00121a017
	CHEMBL168841	58822	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	614	29	4	6	8.7	CSc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1SC	10.1021/jm00121a017
	44380972	120248	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	611	31	4	6	8.0	COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL352334	120248	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	611	31	4	6	8.0	COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	14939888	10160	None	0	Human	Functional	pKd	=	6.6	6.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	370	21	2	4	4.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN	10.1021/jm00046a021
	CHEMBL115878	10160	None	0	Human	Functional	pKd	=	6.6	6.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	370	21	2	4	4.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN	10.1021/jm00046a021
	44381066	59022	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1cncc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccnc2)c1	10.1021/jm00121a017
	CHEMBL169290	59022	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1cncc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccnc2)c1	10.1021/jm00121a017
	14939894	10294	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL116172	10294	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44406598	73023	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200957	73023	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	129989	451	None	51	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	8584	451	None	51	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	CHEMBL43383	451	None	51	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	71128	96808	None	25	Human	Functional	pKd	=	8.5	8.5	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	CHEMBL26505	96808	None	25	Human	Functional	pKd	=	8.5	8.5	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	66875589	103388	None	0	Human	Functional	pKd	=	8.4	8.4	-	1	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084662	103388	None	0	Human	Functional	pKd	=	8.4	8.4	-	1	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589576	189054	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL509520	189054	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555706	189054	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44406480	72842	None	0	Human	Functional	pKd	=	7.5	7.5	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200210	72842	None	0	Human	Functional	pKd	=	7.5	7.5	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44319009	106934	None	0	Human	Functional	pKd	=	7.5	7.5	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL314831	106934	None	0	Human	Functional	pKd	=	7.5	7.5	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11249888	187375	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	442	6	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(C#N)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL493465	187375	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	442	6	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(C#N)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	14537192	100222	None	0	Human	Functional	pKd	=	5.5	5.5	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL288482	100222	None	0	Human	Functional	pKd	=	5.5	5.5	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	189509	105998	None	13	Rat	Functional	pKd	=	5.5	5.5	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL313227	105998	None	13	Rat	Functional	pKd	=	5.5	5.5	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44365882	58122	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	625	32	4	6	8.4	COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL167690	58122	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	625	32	4	6	8.4	COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	2028	2977	None	80	Human	Functional	pKd	=	7.4	7.4	-7	14	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	359	2977	None	80	Human	Functional	pKd	=	7.4	7.4	-7	14	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	4634	2977	None	80	Human	Functional	pKd	=	7.4	7.4	-7	14	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	CHEMBL1231	2977	None	80	Human	Functional	pKd	=	7.4	7.4	-7	14	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	DB01062	2977	None	80	Human	Functional	pKd	=	7.4	7.4	-7	14	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	44406520	135256	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL372566	135256	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	15114860	107154	None	0	Rat	Functional	pKd	=	6.4	6.4	-	0	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	210	3	1	4	1.0	CC[C@@H]1C(O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL316282	107154	None	0	Rat	Functional	pKd	=	6.4	6.4	-	0	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	210	3	1	4	1.0	CC[C@@H]1C(O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	14211057	111423	None	0	Rat	Functional	pKd	=	5.4	5.4	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL327363	111423	None	0	Rat	Functional	pKd	=	5.4	5.4	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	10316726	12026	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	12026	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	12026	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	16115945	12295	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1184886	12295	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL376057	12295	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	10606253	157271	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL407678	157271	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	14939895	82117	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201997	82117	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216629	82117	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10055202	11531	None	1	Human	Functional	pKd	=	6.4	6.4	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm9810452
	CHEMBL11805	11531	None	1	Human	Functional	pKd	=	6.4	6.4	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm9810452
	14939897	96547	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201994	96547	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL262913	96547	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44233192	106480	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084643	106480	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140141	106480	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	11504490	192600	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL521523	192600	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	11504490	192600	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1016/j.bmcl.2009.01.098
	CHEMBL521523	192600	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1016/j.bmcl.2009.01.098
	44589582	171639	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL446587	171639	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL550885	171639	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16042745	185299	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL485932	185299	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL538360	185299	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	10557581	21772	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202001	21772	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL131913	21772	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10418181	9584	None	1	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112500	9584	None	1	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201995	9584	None	1	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	9843814	127247	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	CHEMBL36583	127247	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	14449843	24820	None	0	Human	Functional	pKd	=	6.3	6.3	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	610	27	4	6	6.3	COc1ccccc1CNCCCCCC(=O)NCCCCCCCCNC(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL134488	24820	None	0	Human	Functional	pKd	=	6.3	6.3	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	610	27	4	6	6.3	COc1ccccc1CNCCCCCC(=O)NCCCCCCCCNC(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	14211049	106986	None	0	Rat	Functional	pKd	=	5.3	5.3	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL315191	106986	None	0	Rat	Functional	pKd	=	5.3	5.3	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	2200	3129	None	46	Human	Functional	pKd	=	4.3	4.3	-114	10	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	328	3129	None	46	Human	Functional	pKd	=	4.3	4.3	-114	10	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	4848	3129	None	46	Human	Functional	pKd	=	4.3	4.3	-114	10	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	CHEMBL9967	3129	None	46	Human	Functional	pKd	=	4.3	4.3	-114	10	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	DB00670	3129	None	46	Human	Functional	pKd	=	4.3	4.3	-114	10	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	44381142	59061	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccn2)nc1	10.1021/jm00121a017
	CHEMBL169523	59061	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccn2)nc1	10.1021/jm00121a017
	10653319	24241	None	0	Human	Functional	pKd	=	5.3	5.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	24	3	10	7.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL133993	24241	None	0	Human	Functional	pKd	=	5.3	5.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	24	3	10	7.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44380591	58749	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	CHEMBL168616	58749	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	44406521	73904	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL201933	73904	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44233190	103400	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084679	103400	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589578	173168	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	CHEMBL452193	173168	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	CHEMBL540401	173168	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	44589577	188966	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	CHEMBL508343	188966	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	CHEMBL540146	188966	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	25132856	187214	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	515	8	3	5	3.6	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL492437	187214	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	515	8	3	5	3.6	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	14537188	136544	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL37372	136544	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	14211052	206534	None	0	Rat	Functional	pKd	=	6.2	6.2	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	240	3	0	4	2.7	CC[C@H]1C(=S)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL88578	206534	None	0	Rat	Functional	pKd	=	6.2	6.2	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	240	3	0	4	2.7	CC[C@H]1C(=S)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44380614	57465	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1Cl	10.1021/jm00121a017
	CHEMBL165700	57465	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1Cl	10.1021/jm00121a017
	59993948	73140	None	0	Human	Functional	pKd	=	6.2	6.2	-	0	Orthosteric antagonist activity at M2 receptor by AS-MS analysisOrthosteric antagonist activity at M2 receptor by AS-MS analysis	ChEMBL	556	8	1	6	5.3	O=C(N[C@H]1CCCC[C@@H]1OCc1ccccc1)c1coc(-c2ccc(C(=O)N3CCC(N4CCCC4)CC3)cc2)n1	10.1016/j.bmc.2011.11.071
	CHEMBL2011501	73140	None	0	Human	Functional	pKd	=	6.2	6.2	-	0	Orthosteric antagonist activity at M2 receptor by AS-MS analysisOrthosteric antagonist activity at M2 receptor by AS-MS analysis	ChEMBL	556	8	1	6	5.3	O=C(N[C@H]1CCCC[C@@H]1OCc1ccccc1)c1coc(-c2ccc(C(=O)N3CCC(N4CCCC4)CC3)cc2)n1	10.1016/j.bmc.2011.11.071
	14537189	162641	None	0	Human	Functional	pKd	=	7.1	7.1	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL416974	162641	None	0	Human	Functional	pKd	=	7.1	7.1	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	14939893	9532	None	0	Human	Functional	pKd	=	8.1	8.1	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112244	9532	None	0	Human	Functional	pKd	=	8.1	8.1	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10369736	59362	None	0	Human	Functional	pKd	=	8.1	8.1	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	530	27	4	6	7.0	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1	10.1021/jm00121a017
	CHEMBL170793	59362	None	0	Human	Functional	pKd	=	8.1	8.1	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	530	27	4	6	7.0	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1	10.1021/jm00121a017
	44381205	57525	None	0	Human	Functional	pKd	=	7.1	7.1	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	522	27	4	4	7.2	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccc2)cc1	10.1021/jm00121a017
	CHEMBL166232	57525	None	0	Human	Functional	pKd	=	7.1	7.1	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	522	27	4	4	7.2	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccc2)cc1	10.1021/jm00121a017
	10508599	115227	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	663	23	3	7	5.6	CN(CCCCCCCCN(C)C(=O)CCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL334690	115227	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	663	23	3	7	5.6	CN(CCCCCCCCN(C)C(=O)CCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44381378	57524	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	502	27	4	6	6.4	c1coc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccco2)c1	10.1021/jm00121a017
	CHEMBL166229	57524	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	502	27	4	6	6.4	c1coc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccco2)c1	10.1021/jm00121a017
	129989	451	None	51	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	8584	451	None	51	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	CHEMBL43383	451	None	51	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	10651844	115487	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL335115	115487	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	14914761	9962	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	462	25	4	5	5.4	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN	10.1021/jm00046a021
	CHEMBL114738	9962	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	462	25	4	5	5.4	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN	10.1021/jm00046a021
	44380975	57605	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	612	29	4	8	7.0	O=[N+]([O-])c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm00121a017
	CHEMBL166803	57605	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	612	29	4	8	7.0	O=[N+]([O-])c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm00121a017
	44365718	58784	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	653	34	4	6	9.2	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168786	58784	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	653	34	4	6	9.2	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	9916852	204917	None	0	Human	Functional	pKi	=	11	11.0	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	CHEMBL76164	204917	None	0	Human	Functional	pKi	=	11	11.0	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	44314347	102861	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	640	7	0	7	5.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL305693	102861	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	640	7	0	7	5.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10230930	80632	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity at human muscarinic M2 receptorAntagonist activity at human muscarinic M2 receptor	ChEMBL	548	13	1	5	5.7	CCN(CC)CCOc1ccc(CN2CCC(C3CCN(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)cc1	10.1021/jm100064d
	CHEMBL2151158	80632	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity at human muscarinic M2 receptorAntagonist activity at human muscarinic M2 receptor	ChEMBL	548	13	1	5	5.7	CCN(CC)CCOc1ccc(CN2CCC(C3CCN(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)cc1	10.1021/jm100064d
	44314697	104178	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL309720	104178	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314564	204806	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL75108	204806	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164610746	188465	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	188465	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	188465	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314328	103709	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)ccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL308787	103709	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)ccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10417432	104872	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	718	7	0	7	6.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(Br)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL311099	104872	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	718	7	0	7	6.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(Br)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10009554	204709	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL74141	204709	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314698	205150	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(F)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL78131	205150	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(F)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164610746	188465	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	188465	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	188465	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314329	204554	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL72932	204554	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314699	103177	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL308166	103177	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314713	104868	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	674	7	0	7	6.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(Cl)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL311054	104868	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	674	7	0	7	6.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(Cl)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164615651	188509	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	188509	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	188509	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164614830	188498	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4858774	188498	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028275	188498	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314554	105681	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	592	9	0	8	3.6	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	CHEMBL312571	105681	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	592	9	0	8	3.6	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	3009356	105621	None	1	Human	Functional	pKi	=	5.5	5.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	543	6	0	5	5.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	CHEMBL312344	105621	None	1	Human	Functional	pKi	=	5.5	5.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	543	6	0	5	5.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	483747	105407	None	3	Human	Functional	pKi	=	6.3	6.3	-	1	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	CHEMBL311795	105407	None	3	Human	Functional	pKi	=	6.3	6.3	-	1	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	3009352	96637	None	1	Human	Functional	pKi	=	5.3	5.3	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	517	5	0	5	5.3	CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	CHEMBL263555	96637	None	1	Human	Functional	pKi	=	5.3	5.3	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	517	5	0	5	5.3	CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	3009353	168023	None	1	Human	Functional	pKi	=	5.3	5.3	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	531	6	0	5	5.7	CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	CHEMBL432170	168023	None	1	Human	Functional	pKi	=	5.3	5.3	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	531	6	0	5	5.7	CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	1935	3732	None	97	Human	Functional	pKi	=	5.2	5.2	-57	12	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	2551	3732	None	97	Human	Functional	pKi	=	5.2	5.2	-57	12	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	6687	3732	None	97	Human	Functional	pKi	=	5.2	5.2	-57	12	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	CHEMBL95	3732	None	97	Human	Functional	pKi	=	5.2	5.2	-57	12	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	DB00382	3732	None	97	Human	Functional	pKi	=	5.2	5.2	-57	12	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	164615651	188509	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	188509	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	188509	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	313	2689	None	0	Human	Functional	pA2	<	6.3	6.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9862767
	2520	204006	None	70	Pig	Functional	pEC50	=	8.4	8.4	-3	20	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL1280	204006	None	70	Pig	Functional	pEC50	=	8.4	8.4	-3	20	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL6966	204006	None	70	Pig	Functional	pEC50	=	8.4	8.4	-3	20	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	1935	3732	None	97	Pig	Functional	pEC50	=	8.3	8.3	-1	12	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	2551	3732	None	97	Pig	Functional	pEC50	=	8.3	8.3	-1	12	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	6687	3732	None	97	Pig	Functional	pEC50	=	8.3	8.3	-1	12	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	CHEMBL95	3732	None	97	Pig	Functional	pEC50	=	8.3	8.3	-1	12	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	DB00382	3732	None	97	Pig	Functional	pEC50	=	8.3	8.3	-1	12	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	1979	77324	None	70	Human	Functional	pEC50	=	8.2	8.2	-43	7	NoneNone	Drug Central	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77324	None	70	Human	Functional	pEC50	=	8.2	8.2	-43	7	NoneNone	Drug Central	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	123603	882	None	29	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	2684	882	None	29	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	584	882	None	29	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	9658	882	None	29	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	CHEMBL168815	882	None	29	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	DB00185	882	None	29	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	2370	622	None	31	Guinea pig	Functional	pEC50	=	8.2	8.2	19	3	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	297	622	None	31	Guinea pig	Functional	pEC50	=	8.2	8.2	19	3	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	358	622	None	31	Guinea pig	Functional	pEC50	=	8.2	8.2	19	3	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	CHEMBL1482	622	None	31	Guinea pig	Functional	pEC50	=	8.2	8.2	19	3	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	DB01019	622	None	31	Guinea pig	Functional	pEC50	=	8.2	8.2	19	3	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	1273	1752	None	16	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1752	None	16	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1752	None	16	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1752	None	16	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1752	None	16	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1752	None	16	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1752	None	16	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	2166	3121	None	49	Human	Functional	pEC50	=	8.2	8.2	-28	10	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	305	3121	None	49	Human	Functional	pEC50	=	8.2	8.2	-28	10	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5910	3121	None	49	Human	Functional	pEC50	=	8.2	8.2	-28	10	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	CHEMBL550	3121	None	49	Human	Functional	pEC50	=	8.2	8.2	-28	10	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	DB01085	3121	None	49	Human	Functional	pEC50	=	8.2	8.2	-28	10	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5831	215961	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	5	NoneNone	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	5	NoneNone	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	5	NoneNone	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	21158560	112791	None	7	Pig	Functional	pEC50	=	8.1	8.1	3090	2	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	CHEMBL3305985	112791	None	7	Pig	Functional	pEC50	=	8.1	8.1	3090	2	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	10101670	1508	None	0	Human	Functional	pEC50	=	7.1	7.1	52	2	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	7635	1508	None	0	Human	Functional	pEC50	=	7.1	7.1	52	2	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	CHEMBL32985	1508	None	0	Human	Functional	pEC50	=	7.1	7.1	52	2	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	10104167	2057	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	10104167	2057	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	6937	2057	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	6937	2057	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	CHEMBL3121473	2057	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	CHEMBL3121473	2057	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	288	252	None	0	Human	Functional	pEC50	None	5.7	5.7	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	17392404
	288	252	None	0	Human	Functional	pEC50	None	5.7	5.7	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	8968358
	6979053	252	None	0	Human	Functional	pEC50	None	5.7	5.7	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	17392404
	6979053	252	None	0	Human	Functional	pEC50	None	5.7	5.7	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	8968358
	286	251	None	0	Human	Functional	pEC50	None	6.3	6.3	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	17392404
	286	251	None	0	Human	Functional	pEC50	None	6.3	6.3	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	8968358
	6954180	251	None	0	Human	Functional	pEC50	None	6.3	6.3	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	17392404
	6954180	251	None	0	Human	Functional	pEC50	None	6.3	6.3	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	8968358
	18381	217705	None	0	Human	Functional	pIC50	=	8.3	8.3	-1	4	NoneNone	Drug Central	469	4	2	6	3.2	CC1=C(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(O)=O)C(=NO1)C1=C(Cl)C=CC=C1Cl	None
	11434515	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	11434515	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	11519741	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	11519741	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	4484	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	4484	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	7449	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	7449	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	CHEMBL1194325	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	CHEMBL1194325	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	DB08897	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	DB08897	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	1935	3732	None	97	Mouse	Functional	pIC50	=	5.7	5.7	-19	12	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	2551	3732	None	97	Mouse	Functional	pIC50	=	5.7	5.7	-19	12	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	6687	3732	None	97	Mouse	Functional	pIC50	=	5.7	5.7	-19	12	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	CHEMBL95	3732	None	97	Mouse	Functional	pIC50	=	5.7	5.7	-19	12	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	DB00382	3732	None	97	Mouse	Functional	pIC50	=	5.7	5.7	-19	12	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	154059	3635	None	51	Human	Functional	pIC50	=	6.2	6.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	2457	3635	None	51	Human	Functional	pIC50	=	6.2	6.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	7483	3635	None	51	Human	Functional	pIC50	=	6.2	6.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	CHEMBL1734	3635	None	51	Human	Functional	pIC50	=	6.2	6.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	DB01591	3635	None	51	Human	Functional	pIC50	=	6.2	6.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	11693	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	11693	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	3494	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	3494	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	4302	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	4302	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	7459	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	7459	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	9933193	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	9933193	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	CHEMBL1201335	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	CHEMBL1201335	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	DB00986	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	DB00986	1825	None	16	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3000322	3560	None	38	Human	Binding	pAC50	=	9.2	9.2	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3560	None	38	Human	Binding	pAC50	=	9.2	9.2	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3560	None	38	Human	Binding	pAC50	=	9.2	9.2	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3560	None	38	Human	Binding	pAC50	=	9.2	9.2	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	11434515	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	11519741	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	4484	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	7449	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL1194325	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	DB08897	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	367	3822	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	5487427	3822	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	8592	3822	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL1900528	3822	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3305968	3822	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL4650755	3822	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB01409	3822	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	11693	1825	None	16	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1825	None	16	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1825	None	16	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1825	None	16	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	9933193	1825	None	16	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1825	None	16	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1825	None	16	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	25897919	55650	None	14	Human	Binding	pAC50	=	9.1	9.1	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657308	55650	None	14	Human	Binding	pAC50	=	9.1	9.1	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657309	55650	None	14	Human	Binding	pAC50	=	9.1	9.1	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1464005	55650	None	14	Human	Binding	pAC50	=	9.1	9.1	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1621597	55650	None	14	Human	Binding	pAC50	=	9.1	9.1	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	DB00332	55650	None	14	Human	Binding	pAC50	=	9.1	9.1	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	25897919	55650	None	14	Human	Binding	pAC50	=	8.9	8.9	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657308	55650	None	14	Human	Binding	pAC50	=	8.9	8.9	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657309	55650	None	14	Human	Binding	pAC50	=	8.9	8.9	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1464005	55650	None	14	Human	Binding	pAC50	=	8.9	8.9	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1621597	55650	None	14	Human	Binding	pAC50	=	8.9	8.9	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	DB00332	55650	None	14	Human	Binding	pAC50	=	8.9	8.9	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	11693	1825	None	16	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1825	None	16	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1825	None	16	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1825	None	16	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	9933193	1825	None	16	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1825	None	16	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1825	None	16	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	2705	3840	None	64	Human	Binding	pAC50	=	8.0	8.0	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3840	None	64	Human	Binding	pAC50	=	8.0	8.0	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3840	None	64	Human	Binding	pAC50	=	8.0	8.0	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3840	None	64	Human	Binding	pAC50	=	8.0	8.0	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3840	None	64	Human	Binding	pAC50	=	8.0	8.0	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	3157	1469	None	71	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1469	None	71	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1469	None	71	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1469	None	71	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1469	None	71	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	242	470	None	124	Human	Binding	pAC50	=	5.0	5.0	-295	52	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	124	Human	Binding	pAC50	=	5.0	5.0	-295	52	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	124	Human	Binding	pAC50	=	5.0	5.0	-295	52	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	124	Human	Binding	pAC50	=	5.0	5.0	-295	52	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	124	Human	Binding	pAC50	=	5.0	5.0	-295	52	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	133	2494	None	52	Human	Binding	pAC50	=	5.0	5.0	-	43	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	1723	2494	None	52	Human	Binding	pAC50	=	5.0	5.0	-	43	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	28693	2494	None	52	Human	Binding	pAC50	=	5.0	5.0	-	43	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	CHEMBL19215	2494	None	52	Human	Binding	pAC50	=	5.0	5.0	-	43	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	DB13520	2494	None	52	Human	Binding	pAC50	=	5.0	5.0	-	43	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	CHEMBL1630575	56341	None	0	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
	441383	20331	None	57	Human	Binding	pAC50	=	5.0	5.0	-7	17	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1306	20331	None	57	Human	Binding	pAC50	=	5.0	5.0	-7	17	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	2335	11846	None	22	Human	Binding	pAC50	=	6.0	6.0	-2	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11846	None	22	Human	Binding	pAC50	=	6.0	6.0	-2	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11846	None	22	Human	Binding	pAC50	=	6.0	6.0	-2	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11846	None	22	Human	Binding	pAC50	=	6.0	6.0	-2	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	4919	206232	None	23	Human	Binding	pAC50	=	7.0	7.0	-3	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL86715	206232	None	23	Human	Binding	pAC50	=	7.0	7.0	-3	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	DB00387	206232	None	23	Human	Binding	pAC50	=	7.0	7.0	-3	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	3652	4095	None	79	Human	Binding	pAC50	=	7.0	7.0	-18	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	57	4095	None	79	Human	Binding	pAC50	=	7.0	7.0	-18	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809	4095	None	79	Human	Binding	pAC50	=	7.0	7.0	-18	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	CHEMBL21536	4095	None	79	Human	Binding	pAC50	=	7.0	7.0	-18	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	DB15357	4095	None	79	Human	Binding	pAC50	=	7.0	7.0	-18	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	3152	188409	None	103	Human	Binding	pAC50	=	6.0	6.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	CHEMBL502	188409	None	103	Human	Binding	pAC50	=	6.0	6.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	2200	3129	None	46	Human	Binding	pAC50	=	6.0	6.0	-35	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	328	3129	None	46	Human	Binding	pAC50	=	6.0	6.0	-35	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848	3129	None	46	Human	Binding	pAC50	=	6.0	6.0	-35	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	CHEMBL9967	3129	None	46	Human	Binding	pAC50	=	6.0	6.0	-35	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	DB00670	3129	None	46	Human	Binding	pAC50	=	6.0	6.0	-35	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	1613	2346	None	53	Human	Binding	pAC50	=	6.0	6.0	-42	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2346	None	53	Human	Binding	pAC50	=	6.0	6.0	-42	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2346	None	53	Human	Binding	pAC50	=	6.0	6.0	-42	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2346	None	53	Human	Binding	pAC50	=	6.0	6.0	-42	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2346	None	53	Human	Binding	pAC50	=	6.0	6.0	-42	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	43815	186918	None	64	Human	Binding	pAC50	=	5.9	5.9	-15	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186918	None	64	Human	Binding	pAC50	=	5.9	5.9	-15	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186918	None	64	Human	Binding	pAC50	=	5.9	5.9	-15	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	1209	1656	None	75	Human	Binding	pAC50	=	4.9	4.9	-22	32	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1656	None	75	Human	Binding	pAC50	=	4.9	4.9	-22	32	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1656	None	75	Human	Binding	pAC50	=	4.9	4.9	-22	32	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1656	None	75	Human	Binding	pAC50	=	4.9	4.9	-22	32	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1656	None	75	Human	Binding	pAC50	=	4.9	4.9	-22	32	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	5994	4639	None	88	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL103	4639	None	88	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	2200	3129	None	46	Human	Binding	pAC50	=	5.9	5.9	-35	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	328	3129	None	46	Human	Binding	pAC50	=	5.9	5.9	-35	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848	3129	None	46	Human	Binding	pAC50	=	5.9	5.9	-35	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	CHEMBL9967	3129	None	46	Human	Binding	pAC50	=	5.9	5.9	-35	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	DB00670	3129	None	46	Human	Binding	pAC50	=	5.9	5.9	-35	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	5050	78198	None	58	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	355	4	1	5	3.5	Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL2105300	78198	None	58	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	355	4	1	5	3.5	Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C	10.1038/s41467-023-40064-9
	31315	93406	None	63	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	2	3	3	3.4	O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL245807	93406	None	63	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	2	3	3	3.4	O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	5353853	17984	None	47	Human	Binding	pAC50	=	4.9	4.9	-	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9556529	17984	None	47	Human	Binding	pAC50	=	4.9	4.9	-	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1262	17984	None	47	Human	Binding	pAC50	=	4.9	4.9	-	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	73348210	210947	None	0	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
	CHEMBL3039583	210947	None	0	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
	3775	14473	None	26	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201232	14473	None	26	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB01625	14473	None	26	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	4097	14480	None	13	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1201264	14480	None	13	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	DB00940	14480	None	13	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	2774	3866	None	95	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593	3866	None	95	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	7319	3866	None	95	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	CHEMBL1200604	3866	None	95	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB00809	3866	None	95	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB01199	3866	None	95	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	2402	3368	None	62	Human	Binding	pAC50	=	4.9	4.9	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3368	None	62	Human	Binding	pAC50	=	4.9	4.9	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3368	None	62	Human	Binding	pAC50	=	4.9	4.9	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3368	None	62	Human	Binding	pAC50	=	4.9	4.9	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3368	None	62	Human	Binding	pAC50	=	4.9	4.9	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	15387	45820	None	55	Human	Binding	pAC50	=	4.9	4.9	-16	24	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1531134	45820	None	55	Human	Binding	pAC50	=	4.9	4.9	-16	24	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	1273	1752	None	16	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	3450	1752	None	16	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	356	1752	None	16	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	6172	1752	None	16	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	67425	1752	None	16	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	CHEMBL360055	1752	None	16	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	DB00483	1752	None	16	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	4904	155519	None	48	Human	Binding	pAC50	=	6.9	6.9	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL404215	155519	None	48	Human	Binding	pAC50	=	6.9	6.9	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4209	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	176870	195483	None	106	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	10	1	7	3.4	C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1	10.1038/s41467-023-40064-9
	CHEMBL553	195483	None	106	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	10	1	7	3.4	C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1	10.1038/s41467-023-40064-9
	4209	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3161	None	75	Human	Binding	pAC50	=	4.9	4.9	-	33	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	3678	94790	None	57	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL253371	94790	None	57	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	DB01616	94790	None	57	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	460612	206042	None	66	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
	6918992	206042	None	66	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL852	206042	None	66	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
	5282592	14474	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	6646	14474	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1200851	14474	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1201235	14474	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1615437	14474	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	DB00725	14474	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	16222096	80481	None	67	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	CHEMBL2146883	80481	None	67	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	6918456	14513	None	110	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
	CHEMBL1201772	14513	None	110	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
	DB06209	14513	None	110	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
	103	4151	None	61	Human	Binding	pAC50	=	5.9	5.9	-177	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4151	None	61	Human	Binding	pAC50	=	5.9	5.9	-177	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4151	None	61	Human	Binding	pAC50	=	5.9	5.9	-177	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4151	None	61	Human	Binding	pAC50	=	5.9	5.9	-177	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4151	None	61	Human	Binding	pAC50	=	5.9	5.9	-177	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2444	14476	None	26	Human	Binding	pAC50	=	5.9	5.9	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201245	14476	None	26	Human	Binding	pAC50	=	5.9	5.9	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
	DB01237	14476	None	26	Human	Binding	pAC50	=	5.9	5.9	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
	1201549	596	None	24	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	596	None	24	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	596	None	24	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	596	None	24	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	596	None	24	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	596	None	24	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	24958200	8572	None	76	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	320	3	2	4	2.6	NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12	10.1038/s41467-023-40064-9
	CHEMBL1094636	8572	None	76	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	320	3	2	4	2.6	NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12	10.1038/s41467-023-40064-9
	5523	3849	None	25	Human	Binding	pAC50	=	5.8	5.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	8286	3849	None	25	Human	Binding	pAC50	=	5.8	5.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1237044	3849	None	25	Human	Binding	pAC50	=	5.8	5.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	DB00193	3849	None	25	Human	Binding	pAC50	=	5.8	5.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	5426	178683	None	117	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	1	1	4	0.1	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1	10.1038/s41467-023-40064-9
	CHEMBL468	178683	None	117	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	1	1	4	0.1	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1	10.1038/s41467-023-40064-9
	135398745	2912	None	112	Human	Binding	pAC50	=	6.8	6.8	-38	66	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2912	None	112	Human	Binding	pAC50	=	6.8	6.8	-38	66	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2912	None	112	Human	Binding	pAC50	=	6.8	6.8	-38	66	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2912	None	112	Human	Binding	pAC50	=	6.8	6.8	-38	66	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	3627	44127	None	18	Human	Binding	pAC50	=	6.8	6.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1515447	44127	None	18	Human	Binding	pAC50	=	6.8	6.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	3447	206374	None	28	Human	Binding	pAC50	=	5.8	5.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	321	9	3	5	1.8	CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1	10.1038/s41467-023-40064-9
	CHEMBL87563	206374	None	28	Human	Binding	pAC50	=	5.8	5.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	321	9	3	5	1.8	CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1	10.1038/s41467-023-40064-9
	2247	505	None	81	Human	Binding	pAC50	=	4.8	4.8	-32	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	81	Human	Binding	pAC50	=	4.8	4.8	-32	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	81	Human	Binding	pAC50	=	4.8	4.8	-32	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	81	Human	Binding	pAC50	=	4.8	4.8	-32	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	81	Human	Binding	pAC50	=	4.8	4.8	-32	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	20299	14503	None	15	Human	Binding	pAC50	=	7.8	7.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1201354	14503	None	15	Human	Binding	pAC50	=	7.8	7.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	DB00505	14503	None	15	Human	Binding	pAC50	=	7.8	7.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	1712	2490	None	43	Human	Binding	pAC50	=	6.8	6.8	-5	22	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	4078	2490	None	43	Human	Binding	pAC50	=	6.8	6.8	-5	22	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	7227	2490	None	43	Human	Binding	pAC50	=	6.8	6.8	-5	22	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	CHEMBL1088	2490	None	43	Human	Binding	pAC50	=	6.8	6.8	-5	22	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	DB00933	2490	None	43	Human	Binding	pAC50	=	6.8	6.8	-5	22	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	4594	42870	None	127	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1038/s41467-023-40064-9
	CHEMBL1503	42870	None	127	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1038/s41467-023-40064-9
	5584	203209	None	44	Human	Binding	pAC50	=	6.8	6.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL644	203209	None	44	Human	Binding	pAC50	=	6.8	6.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	DB00726	203209	None	44	Human	Binding	pAC50	=	6.8	6.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	4735	195113	None	96	Human	Binding	pAC50	=	5.8	5.8	-9	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL361506	195113	None	96	Human	Binding	pAC50	=	5.8	5.8	-9	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL55	195113	None	96	Human	Binding	pAC50	=	5.8	5.8	-9	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	2166	3121	None	49	Human	Binding	pAC50	=	4.8	4.8	-34	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	305	3121	None	49	Human	Binding	pAC50	=	4.8	4.8	-34	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	5910	3121	None	49	Human	Binding	pAC50	=	4.8	4.8	-34	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	CHEMBL550	3121	None	49	Human	Binding	pAC50	=	4.8	4.8	-34	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	DB01085	3121	None	49	Human	Binding	pAC50	=	4.8	4.8	-34	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	2745	3859	None	42	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	5572	3859	None	42	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	66007	3859	None	42	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	7315	3859	None	42	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1490	3859	None	42	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	DB00376	3859	None	42	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	154417	23179	None	60	Human	Binding	pAC50	=	7.8	7.8	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1331216	23179	None	60	Human	Binding	pAC50	=	7.8	7.8	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	5311064	1365	None	46	Human	Binding	pAC50	=	4.8	4.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	534	1365	None	46	Human	Binding	pAC50	=	4.8	4.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	806	1365	None	46	Human	Binding	pAC50	=	4.8	4.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL493682	1365	None	46	Human	Binding	pAC50	=	4.8	4.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	2286	3181	None	51	Human	Binding	pAC50	=	6.8	6.8	-3	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3181	None	51	Human	Binding	pAC50	=	6.8	6.8	-3	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3181	None	51	Human	Binding	pAC50	=	6.8	6.8	-3	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3181	None	51	Human	Binding	pAC50	=	6.8	6.8	-3	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3181	None	51	Human	Binding	pAC50	=	6.8	6.8	-3	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2247	505	None	81	Human	Binding	pAC50	=	5.8	5.8	-32	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	81	Human	Binding	pAC50	=	5.8	5.8	-32	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	81	Human	Binding	pAC50	=	5.8	5.8	-32	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	81	Human	Binding	pAC50	=	5.8	5.8	-32	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	81	Human	Binding	pAC50	=	5.8	5.8	-32	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2480	19438	None	49	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	306	11	1	4	3.7	CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
	CHEMBL129529	19438	None	49	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	306	11	1	4	3.7	CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
	49803313	112584	None	69	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	552	9	3	10	2.7	CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL3301622	112584	None	69	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	552	9	3	10	2.7	CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1	10.1038/s41467-023-40064-9
	3344	198316	None	57	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
	CHEMBL576127	198316	None	57	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
	54758501	139065	None	58	Human	Binding	pAC50	=	5.8	5.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
	CHEMBL3786343	139065	None	58	Human	Binding	pAC50	=	5.8	5.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
	6127	14497	None	8	Human	Binding	pAC50	=	6.8	6.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14497	None	8	Human	Binding	pAC50	=	6.8	6.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB13720	14497	None	8	Human	Binding	pAC50	=	6.8	6.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	72287	61059	None	38	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1764	61059	None	38	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB01403	61059	None	38	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL4743867	214031	None	14	Human	Binding	pAC50	=	5.8	5.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
	71109	78204	None	10	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
	CHEMBL2105453	78204	None	10	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
	24821094	67092	None	93	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67092	None	93	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	62867	3127	None	35	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	7557	3127	None	35	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL398880	3127	None	35	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01621	3127	None	35	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	3103	41656	None	49	Human	Binding	pAC50	=	6.8	6.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1492	41656	None	49	Human	Binding	pAC50	=	6.8	6.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB01146	41656	None	49	Human	Binding	pAC50	=	6.8	6.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	9571107	167517	None	33	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
	CHEMBL430	167517	None	33	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
	2337	3254	None	77	Human	Binding	pAC50	=	5.8	5.8	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3254	None	77	Human	Binding	pAC50	=	5.8	5.8	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3254	None	77	Human	Binding	pAC50	=	5.8	5.8	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3254	None	77	Human	Binding	pAC50	=	5.8	5.8	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3254	None	77	Human	Binding	pAC50	=	5.8	5.8	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5591	157529	None	90	Human	Binding	pAC50	=	4.8	4.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157529	None	90	Human	Binding	pAC50	=	4.8	4.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	1224	1431	None	83	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1431	None	83	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1431	None	83	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1431	None	83	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1431	None	83	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1431	None	83	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	40973	46033	None	70	Human	Binding	pAC50	=	5.7	5.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
	CHEMBL1533	46033	None	70	Human	Binding	pAC50	=	5.7	5.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
	3606	203486	None	60	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL6615	203486	None	60	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	180	401	None	56	Human	Binding	pAC50	=	6.7	6.7	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	56	Human	Binding	pAC50	=	6.7	6.7	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	56	Human	Binding	pAC50	=	6.7	6.7	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	56	Human	Binding	pAC50	=	6.7	6.7	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	56	Human	Binding	pAC50	=	6.7	6.7	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	1599	2339	None	50	Human	Binding	pAC50	=	4.7	4.7	-	16	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	3955	2339	None	50	Human	Binding	pAC50	=	4.7	4.7	-	16	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7215	2339	None	50	Human	Binding	pAC50	=	4.7	4.7	-	16	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL841	2339	None	50	Human	Binding	pAC50	=	4.7	4.7	-	16	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00836	2339	None	50	Human	Binding	pAC50	=	4.7	4.7	-	16	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	135400189	44573	None	73	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
	CHEMBL1520	44573	None	73	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
	135398737	957	None	93	Human	Binding	pAC50	=	6.7	6.7	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	957	None	93	Human	Binding	pAC50	=	6.7	6.7	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	957	None	93	Human	Binding	pAC50	=	6.7	6.7	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	957	None	93	Human	Binding	pAC50	=	6.7	6.7	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	957	None	93	Human	Binding	pAC50	=	6.7	6.7	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	4417	55560	None	54	Human	Binding	pAC50	=	6.7	6.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL1439099	55560	None	54	Human	Binding	pAC50	=	6.7	6.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL1620794	55560	None	54	Human	Binding	pAC50	=	6.7	6.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL5292015	194535	None	0	Human	Binding	pAC50	=	6.7	6.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
	6077	150696	None	31	Human	Binding	pAC50	=	6.7	6.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL39560	150696	None	31	Human	Binding	pAC50	=	6.7	6.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	40466968	207034	None	70	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	60947	207034	None	70	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL916	207034	None	70	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL5291995	194534	None	0	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	5	0	5	3.3	CN(C)CCCN1C(=O)c2cc([N+](=O)[O-])ccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	41049	106758	None	40	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
	CHEMBL314437	106758	None	40	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
	DB13478	106758	None	40	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
	18609376	204357	None	63	Human	Binding	pAC50	=	4.7	4.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	6279	204357	None	63	Human	Binding	pAC50	=	4.7	4.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL717	204357	None	63	Human	Binding	pAC50	=	4.7	4.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	3294	2004	None	111	Human	Binding	pAC50	=	5.7	5.7	-194	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2004	None	111	Human	Binding	pAC50	=	5.7	5.7	-194	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2004	None	111	Human	Binding	pAC50	=	5.7	5.7	-194	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2004	None	111	Human	Binding	pAC50	=	5.7	5.7	-194	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2004	None	111	Human	Binding	pAC50	=	5.7	5.7	-194	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	1726	2495	None	13	Human	Binding	pAC50	=	5.7	5.7	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	1993	2495	None	13	Human	Binding	pAC50	=	5.7	5.7	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	7438	2495	None	13	Human	Binding	pAC50	=	5.7	5.7	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	CHEMBL978	2495	None	13	Human	Binding	pAC50	=	5.7	5.7	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	DB06709	2495	None	13	Human	Binding	pAC50	=	5.7	5.7	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	5440	28722	None	37	Human	Binding	pAC50	=	5.7	5.7	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1378	28722	None	37	Human	Binding	pAC50	=	5.7	5.7	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB00372	28722	None	37	Human	Binding	pAC50	=	5.7	5.7	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	193962	103791	None	106	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
	CHEMBL308954	103791	None	106	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
	9853053	120517	None	74	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL354541	120517	None	74	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	24821094	67092	None	93	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67092	None	93	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	2895	203590	None	41	Human	Binding	pAC50	=	6.6	6.6	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	203590	None	41	Human	Binding	pAC50	=	6.6	6.6	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	DB00924	203590	None	41	Human	Binding	pAC50	=	6.6	6.6	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	121515	199097	None	63	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL588934	199097	None	63	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	443869	78139	None	45	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL2103761	78139	None	45	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	432824	78262	None	13	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	CHEMBL2106996	78262	None	13	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	10180	98867	None	47	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	CHEMBL279014	98867	None	47	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	208898	66197	None	78	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	CHEMBL184412	66197	None	78	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	DB04855	66197	None	78	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	4761	13439	None	42	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1193	13439	None	42	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1580221	13439	None	42	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	DB01620	13439	None	42	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	1547484	939	None	74	Human	Binding	pAC50	=	5.6	5.6	-	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	654	939	None	74	Human	Binding	pAC50	=	5.6	5.6	-	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	9072	939	None	74	Human	Binding	pAC50	=	5.6	5.6	-	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL43064	939	None	74	Human	Binding	pAC50	=	5.6	5.6	-	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00568	939	None	74	Human	Binding	pAC50	=	5.6	5.6	-	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	151537	162662	None	49	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	41867	162662	None	49	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL417	162662	None	49	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	9324	9236	None	60	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL110691	9236	None	60	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	5039	63181	None	17	Human	Binding	pAC50	=	5.6	5.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	CHEMBL1790041	63181	None	17	Human	Binding	pAC50	=	5.6	5.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	DB00863	63181	None	17	Human	Binding	pAC50	=	5.6	5.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	5284632	67400	None	13	Human	Binding	pAC50	=	7.6	7.6	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1888176	67400	None	13	Human	Binding	pAC50	=	7.6	7.6	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3084748	67400	None	13	Human	Binding	pAC50	=	7.6	7.6	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00209	67400	None	13	Human	Binding	pAC50	=	7.6	7.6	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4642	41984	None	28	Human	Binding	pAC50	=	7.6	7.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1495	41984	None	28	Human	Binding	pAC50	=	7.6	7.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	DB00383	41984	None	28	Human	Binding	pAC50	=	7.6	7.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	4034	55820	None	55	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55820	None	55	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	DB00737	55820	None	55	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	7099	195520	None	59	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
	CHEMBL55400	195520	None	59	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
	9419	35920	None	35	Human	Binding	pAC50	=	5.6	5.6	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1442422	35920	None	35	Human	Binding	pAC50	=	5.6	5.6	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	DB13225	35920	None	35	Human	Binding	pAC50	=	5.6	5.6	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	4940	14468	None	35	Human	Binding	pAC50	=	6.6	6.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14468	None	35	Human	Binding	pAC50	=	6.6	6.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	4021	100478	None	122	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
	CHEMBL290916	100478	None	122	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
	9429	202131	None	58	Human	Binding	pAC50	=	5.6	5.6	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	202131	None	58	Human	Binding	pAC50	=	5.6	5.6	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	DB01622	202131	None	58	Human	Binding	pAC50	=	5.6	5.6	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	3152	188409	None	103	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	CHEMBL502	188409	None	103	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	22530	56128	None	58	Human	Binding	pAC50	=	6.6	6.6	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1600878	56128	None	58	Human	Binding	pAC50	=	6.6	6.6	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1625607	56128	None	58	Human	Binding	pAC50	=	6.6	6.6	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	5351322	94789	None	38	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL25336	94789	None	38	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	708857	56182	None	44	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	206	2	0	3	2.5	CN1CCCN=C1/C=C/c1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1626223	56182	None	44	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	206	2	0	3	2.5	CN1CCCN=C1/C=C/c1cccs1	10.1038/s41467-023-40064-9
	9400	14489	None	38	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	472	4	4	6	2.0	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	10.1038/s41467-023-40064-9
	CHEMBL1201302	14489	None	38	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	472	4	4	6	2.0	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	10.1038/s41467-023-40064-9
	2726	918	None	68	Human	Binding	pAC50	=	5.6	5.6	-79	73	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	918	None	68	Human	Binding	pAC50	=	5.6	5.6	-79	73	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	918	None	68	Human	Binding	pAC50	=	5.6	5.6	-79	73	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	918	None	68	Human	Binding	pAC50	=	5.6	5.6	-79	73	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	918	None	68	Human	Binding	pAC50	=	5.6	5.6	-79	73	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	3180	14471	None	41	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201217	14471	None	41	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	1712095	195390	None	30	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
	CHEMBL551978	195390	None	30	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
	25295	13618	None	37	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1194287	13618	None	37	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	31101	728	None	40	Human	Binding	pAC50	=	4.5	4.5	-	36	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	728	None	40	Human	Binding	pAC50	=	4.5	4.5	-	36	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	728	None	40	Human	Binding	pAC50	=	4.5	4.5	-	36	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	728	None	40	Human	Binding	pAC50	=	4.5	4.5	-	36	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	728	None	40	Human	Binding	pAC50	=	4.5	4.5	-	36	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	22323	15297	None	32	Human	Binding	pAC50	=	4.5	4.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15297	None	32	Human	Binding	pAC50	=	4.5	4.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15297	None	32	Human	Binding	pAC50	=	4.5	4.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	4098	32503	None	30	Human	Binding	pAC50	=	5.5	5.5	-15	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1255739	32503	None	30	Human	Binding	pAC50	=	5.5	5.5	-15	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1411979	32503	None	30	Human	Binding	pAC50	=	5.5	5.5	-15	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	23724781	2833	None	19	Human	Binding	pAC50	=	8.5	8.5	-6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	316	2833	None	19	Human	Binding	pAC50	=	8.5	8.5	-6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	317	2833	None	19	Human	Binding	pAC50	=	8.5	8.5	-6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	71183	2833	None	19	Human	Binding	pAC50	=	8.5	8.5	-6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL1354199	2833	None	19	Human	Binding	pAC50	=	8.5	8.5	-6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3140030	2833	None	19	Human	Binding	pAC50	=	8.5	8.5	-6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL376897	2833	None	19	Human	Binding	pAC50	=	8.5	8.5	-6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB00462	2833	None	19	Human	Binding	pAC50	=	8.5	8.5	-6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	2039	2980	None	19	Human	Binding	pAC50	=	8.5	8.5	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	5749	2980	None	19	Human	Binding	pAC50	=	8.5	8.5	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	7257	2980	None	19	Human	Binding	pAC50	=	8.5	8.5	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	CHEMBL1201286	2980	None	19	Human	Binding	pAC50	=	8.5	8.5	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	DB00219	2980	None	19	Human	Binding	pAC50	=	8.5	8.5	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	2293	3184	None	27	Human	Binding	pAC50	=	8.5	8.5	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	329	3184	None	27	Human	Binding	pAC50	=	8.5	8.5	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	4934	3184	None	27	Human	Binding	pAC50	=	8.5	8.5	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	CHEMBL1180725	3184	None	27	Human	Binding	pAC50	=	8.5	8.5	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	DB00782	3184	None	27	Human	Binding	pAC50	=	8.5	8.5	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	25897919	55650	None	14	Human	Binding	pAC50	=	8.5	8.5	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657308	55650	None	14	Human	Binding	pAC50	=	8.5	8.5	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657309	55650	None	14	Human	Binding	pAC50	=	8.5	8.5	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1464005	55650	None	14	Human	Binding	pAC50	=	8.5	8.5	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1621597	55650	None	14	Human	Binding	pAC50	=	8.5	8.5	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	DB00332	55650	None	14	Human	Binding	pAC50	=	8.5	8.5	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	6917866	167435	None	5	Human	Binding	pAC50	=	8.5	8.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	4	1.5	CC[N+]1(C)[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL4297364	167435	None	5	Human	Binding	pAC50	=	8.5	8.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	4	1.5	CC[N+]1(C)[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	2784	951	None	13	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	351	951	None	13	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	366	951	None	13	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	676	951	None	13	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL620	951	None	13	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	DB00771	951	None	13	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	174174	523	None	49	Human	Binding	pAC50	=	8.4	8.4	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	260	523	None	49	Human	Binding	pAC50	=	8.4	8.4	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	320	523	None	49	Human	Binding	pAC50	=	8.4	8.4	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	CHEMBL517712	523	None	49	Human	Binding	pAC50	=	8.4	8.4	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	DB00572	523	None	49	Human	Binding	pAC50	=	8.4	8.4	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	2286	3181	None	51	Human	Binding	pAC50	=	7.5	7.5	-3	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3181	None	51	Human	Binding	pAC50	=	7.5	7.5	-3	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3181	None	51	Human	Binding	pAC50	=	7.5	7.5	-3	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3181	None	51	Human	Binding	pAC50	=	7.5	7.5	-3	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3181	None	51	Human	Binding	pAC50	=	7.5	7.5	-3	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	68778	115203	None	68	Human	Binding	pAC50	=	6.5	6.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	2	0	1	4.9	CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL334491	115203	None	68	Human	Binding	pAC50	=	6.5	6.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	2	0	1	4.9	CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	1548955	88579	None	20	Human	Binding	pAC50	=	5.5	5.5	-1	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	2800	88579	None	20	Human	Binding	pAC50	=	5.5	5.5	-1	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL2355051	88579	None	20	Human	Binding	pAC50	=	5.5	5.5	-1	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	100	3803	None	58	Human	Binding	pAC50	=	6.5	6.5	-19	55	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3803	None	58	Human	Binding	pAC50	=	6.5	6.5	-19	55	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3803	None	58	Human	Binding	pAC50	=	6.5	6.5	-19	55	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3803	None	58	Human	Binding	pAC50	=	6.5	6.5	-19	55	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3803	None	58	Human	Binding	pAC50	=	6.5	6.5	-19	55	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	242	470	None	124	Human	Binding	pAC50	=	5.5	5.5	-295	52	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	124	Human	Binding	pAC50	=	5.5	5.5	-295	52	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	124	Human	Binding	pAC50	=	5.5	5.5	-295	52	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	124	Human	Binding	pAC50	=	5.5	5.5	-295	52	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	124	Human	Binding	pAC50	=	5.5	5.5	-295	52	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	3607	36380	None	72	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
	CHEMBL144673	36380	None	72	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
	93154	5434	None	29	Human	Binding	pAC50	=	7.5	7.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL107360	5434	None	29	Human	Binding	pAC50	=	7.5	7.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
	2898	32649	None	73	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	364	4	0	4	5.3	CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL141305	32649	None	73	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	364	4	0	4	5.3	CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1	10.1038/s41467-023-40064-9
	2805	161888	None	38	Human	Binding	pAC50	=	6.5	6.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL415087	161888	None	38	Human	Binding	pAC50	=	6.5	6.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	12555	17959	None	53	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL12610	17959	None	53	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
	6726	1279	None	51	Human	Binding	pAC50	=	6.5	6.5	-9	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7151	1279	None	51	Human	Binding	pAC50	=	6.5	6.5	-9	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	749	1279	None	51	Human	Binding	pAC50	=	6.5	6.5	-9	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL648	1279	None	51	Human	Binding	pAC50	=	6.5	6.5	-9	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB01176	1279	None	51	Human	Binding	pAC50	=	6.5	6.5	-9	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2749	344	None	40	Human	Binding	pAC50	=	6.5	6.5	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	5574	344	None	40	Human	Binding	pAC50	=	6.5	6.5	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7237	344	None	40	Human	Binding	pAC50	=	6.5	6.5	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL829	344	None	40	Human	Binding	pAC50	=	6.5	6.5	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01246	344	None	40	Human	Binding	pAC50	=	6.5	6.5	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	132999	179099	None	47	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	468	10	0	6	3.3	COc1cc2c(cc1OC)CC(=O)N(CCCN(C)C[C@H]1Cc3cc(OC)c(OC)cc31)CC2	10.1038/s41467-023-40064-9
	CHEMBL471737	179099	None	47	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	468	10	0	6	3.3	COc1cc2c(cc1OC)CC(=O)N(CCCN(C)C[C@H]1Cc3cc(OC)c(OC)cc31)CC2	10.1038/s41467-023-40064-9
	3354	41782	None	50	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
	CHEMBL1493	41782	None	50	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
	DB01148	41782	None	50	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
	3166	169418	None	23	Human	Binding	pAC50	=	7.5	7.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL442444	169418	None	23	Human	Binding	pAC50	=	7.5	7.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	5354	155654	None	21	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL404849	155654	None	21	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
	6075	150106	None	42	Human	Binding	pAC50	=	6.5	6.5	-7	16	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	CHEMBL395110	150106	None	42	Human	Binding	pAC50	=	6.5	6.5	-7	16	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	191	403	None	98	Human	Binding	pAC50	=	5.5	5.5	-56	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	403	None	98	Human	Binding	pAC50	=	5.5	5.5	-56	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	403	None	98	Human	Binding	pAC50	=	5.5	5.5	-56	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	403	None	98	Human	Binding	pAC50	=	5.5	5.5	-56	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	403	None	98	Human	Binding	pAC50	=	5.5	5.5	-56	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	213046	2383	None	59	Human	Binding	pAC50	=	5.5	5.5	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2383	None	59	Human	Binding	pAC50	=	5.5	5.5	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2383	None	59	Human	Binding	pAC50	=	5.5	5.5	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2383	None	59	Human	Binding	pAC50	=	5.5	5.5	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2383	None	59	Human	Binding	pAC50	=	5.5	5.5	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	115163	57301	None	44	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	439	5	0	7	2.4	CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C	10.1038/s41467-023-40064-9
	CHEMBL1650818	57301	None	44	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	439	5	0	7	2.4	CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C	10.1038/s41467-023-40064-9
	5583	13042	None	51	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL119	13042	None	51	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
	4601	206745	None	35	Human	Binding	pAC50	=	6.4	6.4	-2	17	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201023	206745	None	35	Human	Binding	pAC50	=	6.4	6.4	-2	17	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL900	206745	None	35	Human	Binding	pAC50	=	6.4	6.4	-2	17	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	DB01173	206745	None	35	Human	Binding	pAC50	=	6.4	6.4	-2	17	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	160883	55262	None	9	Human	Binding	pAC50	=	6.4	6.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	6852391	55262	None	9	Human	Binding	pAC50	=	6.4	6.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1618102	55262	None	9	Human	Binding	pAC50	=	6.4	6.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	DB09300	55262	None	9	Human	Binding	pAC50	=	6.4	6.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	16960	14485	None	23	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1201287	14485	None	23	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	DB00405	14485	None	23	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	5511	5486	None	40	Human	Binding	pAC50	=	5.4	5.4	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	4	0	2	3.3	Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1076211	5486	None	40	Human	Binding	pAC50	=	5.4	5.4	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	4	0	2	3.3	Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	2333	142333	None	97	Human	Binding	pAC50	=	7.4	7.4	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142333	None	97	Human	Binding	pAC50	=	7.4	7.4	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	124087	1388	None	114	Human	Binding	pAC50	=	7.4	7.4	-6	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1388	None	114	Human	Binding	pAC50	=	7.4	7.4	-6	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1388	None	114	Human	Binding	pAC50	=	7.4	7.4	-6	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1388	None	114	Human	Binding	pAC50	=	7.4	7.4	-6	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1388	None	114	Human	Binding	pAC50	=	7.4	7.4	-6	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	16362	3123	None	71	Human	Binding	pAC50	=	5.4	5.4	-	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3123	None	71	Human	Binding	pAC50	=	5.4	5.4	-	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3123	None	71	Human	Binding	pAC50	=	5.4	5.4	-	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3123	None	71	Human	Binding	pAC50	=	5.4	5.4	-	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3123	None	71	Human	Binding	pAC50	=	5.4	5.4	-	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3055	1432	None	44	Human	Binding	pAC50	=	6.4	6.4	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	313	1432	None	44	Human	Binding	pAC50	=	6.4	6.4	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	7163	1432	None	44	Human	Binding	pAC50	=	6.4	6.4	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL936	1432	None	44	Human	Binding	pAC50	=	6.4	6.4	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	DB01231	1432	None	44	Human	Binding	pAC50	=	6.4	6.4	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	135	2530	None	43	Human	Binding	pAC50	=	5.4	5.4	-25	58	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2530	None	43	Human	Binding	pAC50	=	5.4	5.4	-25	58	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2530	None	43	Human	Binding	pAC50	=	5.4	5.4	-25	58	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2530	None	43	Human	Binding	pAC50	=	5.4	5.4	-25	58	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2530	None	43	Human	Binding	pAC50	=	5.4	5.4	-25	58	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	60663	175667	None	42	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1421212	175667	None	42	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1534525	175667	None	42	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL45816	175667	None	42	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	3000322	3560	None	38	Human	Binding	pAC50	=	7.4	7.4	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3560	None	38	Human	Binding	pAC50	=	7.4	7.4	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3560	None	38	Human	Binding	pAC50	=	7.4	7.4	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3560	None	38	Human	Binding	pAC50	=	7.4	7.4	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	3053	205132	None	95	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL780	205132	None	95	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	43082	60281	None	37	Human	Binding	pAC50	=	6.4	6.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1742452	60281	None	37	Human	Binding	pAC50	=	6.4	6.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	11519069	3937	None	3	Human	Binding	pAC50	=	8.4	8.4	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	11519070	3937	None	3	Human	Binding	pAC50	=	8.4	8.4	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4816	3937	None	3	Human	Binding	pAC50	=	8.4	8.4	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7354	3937	None	3	Human	Binding	pAC50	=	8.4	8.4	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187833	3937	None	3	Human	Binding	pAC50	=	8.4	8.4	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB09076	3937	None	3	Human	Binding	pAC50	=	8.4	8.4	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	11693	1825	None	16	Human	Binding	pAC50	=	8.4	8.4	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1825	None	16	Human	Binding	pAC50	=	8.4	8.4	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1825	None	16	Human	Binding	pAC50	=	8.4	8.4	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1825	None	16	Human	Binding	pAC50	=	8.4	8.4	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	9933193	1825	None	16	Human	Binding	pAC50	=	8.4	8.4	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1825	None	16	Human	Binding	pAC50	=	8.4	8.4	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1825	None	16	Human	Binding	pAC50	=	8.4	8.4	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	10470	2486	None	7	Human	Binding	pAC50	=	8.4	8.4	-4	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	1689	2486	None	7	Human	Binding	pAC50	=	8.4	8.4	-4	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4057	2486	None	7	Human	Binding	pAC50	=	8.4	8.4	-4	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL524004	2486	None	7	Human	Binding	pAC50	=	8.4	8.4	-4	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB04843	2486	None	7	Human	Binding	pAC50	=	8.4	8.4	-4	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	180	401	None	56	Human	Binding	pAC50	=	7.4	7.4	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	56	Human	Binding	pAC50	=	7.4	7.4	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	56	Human	Binding	pAC50	=	7.4	7.4	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	56	Human	Binding	pAC50	=	7.4	7.4	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	56	Human	Binding	pAC50	=	7.4	7.4	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4886	14108	None	28	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1198	14108	None	28	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
	4919	206232	None	23	Human	Binding	pAC50	=	6.4	6.4	-3	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL86715	206232	None	23	Human	Binding	pAC50	=	6.4	6.4	-3	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	DB00387	206232	None	23	Human	Binding	pAC50	=	6.4	6.4	-3	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	6918558	14512	None	41	Human	Binding	pAC50	=	6.4	6.4	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201764	14512	None	41	Human	Binding	pAC50	=	6.4	6.4	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	DB06702	14512	None	41	Human	Binding	pAC50	=	6.4	6.4	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	2771	195015	None	74	Human	Binding	pAC50	=	5.4	5.4	-	27	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	195015	None	74	Human	Binding	pAC50	=	5.4	5.4	-	27	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	195015	None	74	Human	Binding	pAC50	=	5.4	5.4	-	27	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	40	1546	None	58	Human	Binding	pAC50	=	5.4	5.4	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	77993	1546	None	58	Human	Binding	pAC50	=	5.4	5.4	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	995	1546	None	58	Human	Binding	pAC50	=	5.4	5.4	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1510	1546	None	58	Human	Binding	pAC50	=	5.4	5.4	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	DB00216	1546	None	58	Human	Binding	pAC50	=	5.4	5.4	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	1909	2820	None	64	Human	Binding	pAC50	=	6.4	6.4	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	2559	2820	None	64	Human	Binding	pAC50	=	6.4	6.4	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	4474	2820	None	64	Human	Binding	pAC50	=	6.4	6.4	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	CHEMBL1484	2820	None	64	Human	Binding	pAC50	=	6.4	6.4	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	CHEMBL3302409	2820	None	64	Human	Binding	pAC50	=	6.4	6.4	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	DB00622	2820	None	64	Human	Binding	pAC50	=	6.4	6.4	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	54697325	58977	None	35	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1689772	58977	None	35	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	7019	167974	None	106	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL1308088	167974	None	106	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL43184	167974	None	106	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	3474	38099	None	57	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
	CHEMBL146095	38099	None	57	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
	104903	56342	None	17	Human	Binding	pAC50	=	6.4	6.4	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1630578	56342	None	17	Human	Binding	pAC50	=	6.4	6.4	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
	1530	2180	None	50	Human	Binding	pAC50	=	6.4	6.4	-43	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2180	None	50	Human	Binding	pAC50	=	6.4	6.4	-43	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2180	None	50	Human	Binding	pAC50	=	6.4	6.4	-43	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2180	None	50	Human	Binding	pAC50	=	6.4	6.4	-43	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2180	None	50	Human	Binding	pAC50	=	6.4	6.4	-43	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	5330286	67569	None	104	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
	CHEMBL189963	67569	None	104	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
	2580	78393	None	18	Human	Binding	pAC50	=	5.4	5.4	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL2110775	78393	None	18	Human	Binding	pAC50	=	5.4	5.4	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
	3634	84106	None	51	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	CHEMBL22077	84106	None	51	Human	Binding	pAC50	=	5.4	5.4	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	2398	953	None	62	Human	Binding	pAC50	=	6.4	6.4	-3	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	953	None	62	Human	Binding	pAC50	=	6.4	6.4	-3	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	953	None	62	Human	Binding	pAC50	=	6.4	6.4	-3	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	953	None	62	Human	Binding	pAC50	=	6.4	6.4	-3	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	953	None	62	Human	Binding	pAC50	=	6.4	6.4	-3	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	1427	2011	None	54	Human	Binding	pAC50	=	6.3	6.3	1	27	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2011	None	54	Human	Binding	pAC50	=	6.3	6.3	1	27	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2011	None	54	Human	Binding	pAC50	=	6.3	6.3	1	27	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2011	None	54	Human	Binding	pAC50	=	6.3	6.3	1	27	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2011	None	54	Human	Binding	pAC50	=	6.3	6.3	1	27	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4908	188804	None	78	Human	Binding	pAC50	=	5.3	5.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
	CHEMBL506	188804	None	78	Human	Binding	pAC50	=	5.3	5.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
	1086	1588	None	27	Human	Binding	pAC50	=	7.3	7.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	3290	1588	None	27	Human	Binding	pAC50	=	7.3	7.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	7181	1588	None	27	Human	Binding	pAC50	=	7.3	7.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	CHEMBL1206	1588	None	27	Human	Binding	pAC50	=	7.3	7.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	DB00392	1588	None	27	Human	Binding	pAC50	=	7.3	7.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	187	255	None	39	Human	Binding	pAC50	=	6.3	6.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	None	39	Human	Binding	pAC50	=	6.3	6.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	None	39	Human	Binding	pAC50	=	6.3	6.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	None	39	Human	Binding	pAC50	=	6.3	6.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	None	39	Human	Binding	pAC50	=	6.3	6.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	None	39	Human	Binding	pAC50	=	6.3	6.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	10071196	3122	None	79	Human	Binding	pAC50	=	5.3	5.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	5142	3122	None	79	Human	Binding	pAC50	=	5.3	5.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	8423	3122	None	79	Human	Binding	pAC50	=	5.3	5.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	CHEMBL2111101	3122	None	79	Human	Binding	pAC50	=	5.3	5.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	DB05316	3122	None	79	Human	Binding	pAC50	=	5.3	5.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	187	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	319	1323	None	44	Human	Binding	pAC50	=	6.3	6.3	-20	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1323	None	44	Human	Binding	pAC50	=	6.3	6.3	-20	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1323	None	44	Human	Binding	pAC50	=	6.3	6.3	-20	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1323	None	44	Human	Binding	pAC50	=	6.3	6.3	-20	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1323	None	44	Human	Binding	pAC50	=	6.3	6.3	-20	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1323	None	44	Human	Binding	pAC50	=	6.3	6.3	-20	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	2762	3861	None	31	Human	Binding	pAC50	=	5.3	5.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	5587	3861	None	31	Human	Binding	pAC50	=	5.3	5.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	7318	3861	None	31	Human	Binding	pAC50	=	5.3	5.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL1241	3861	None	31	Human	Binding	pAC50	=	5.3	5.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	DB00792	3861	None	31	Human	Binding	pAC50	=	5.3	5.3	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	11057	176147	None	23	Human	Binding	pAC50	=	6.3	6.3	-1	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	3468	176147	None	23	Human	Binding	pAC50	=	6.3	6.3	-1	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL459265	176147	None	23	Human	Binding	pAC50	=	6.3	6.3	-1	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL64894	176147	None	23	Human	Binding	pAC50	=	6.3	6.3	-1	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	187	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	None	39	Human	Binding	pAC50	=	5.3	5.3	6	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	2993	114690	None	24	Human	Binding	pAC50	=	7.3	7.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL121663	114690	None	24	Human	Binding	pAC50	=	7.3	7.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL333826	114690	None	24	Human	Binding	pAC50	=	7.3	7.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	70695647	78211	None	0	Human	Binding	pAC50	=	6.3	6.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	2	1	1	5.3	C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL2105618	78211	None	0	Human	Binding	pAC50	=	6.3	6.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	2	1	1	5.3	C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	11154555	799	None	62	Human	Binding	pAC50	=	5.3	5.3	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	5037	799	None	62	Human	Binding	pAC50	=	5.3	5.3	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	7671	799	None	62	Human	Binding	pAC50	=	5.3	5.3	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL2028019	799	None	62	Human	Binding	pAC50	=	5.3	5.3	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL3085826	799	None	62	Human	Binding	pAC50	=	5.3	5.3	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB06016	799	None	62	Human	Binding	pAC50	=	5.3	5.3	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	5328940	100214	None	107	Human	Binding	pAC50	=	5.3	5.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL288441	100214	None	107	Human	Binding	pAC50	=	5.3	5.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	25151352	140604	None	67	Human	Binding	pAC50	=	6.3	6.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	CHEMBL3813873	140604	None	67	Human	Binding	pAC50	=	6.3	6.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	4167	14498	None	43	Human	Binding	pAC50	=	8.3	8.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1201342	14498	None	43	Human	Binding	pAC50	=	8.3	8.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	DB00340	14498	None	43	Human	Binding	pAC50	=	8.3	8.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	4167	14498	None	43	Human	Binding	pAC50	=	8.3	8.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1201342	14498	None	43	Human	Binding	pAC50	=	8.3	8.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	DB00340	14498	None	43	Human	Binding	pAC50	=	8.3	8.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	174174	523	None	49	Human	Binding	pAC50	=	8.3	8.3	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	260	523	None	49	Human	Binding	pAC50	=	8.3	8.3	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	320	523	None	49	Human	Binding	pAC50	=	8.3	8.3	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	CHEMBL517712	523	None	49	Human	Binding	pAC50	=	8.3	8.3	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	DB00572	523	None	49	Human	Binding	pAC50	=	8.3	8.3	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	277	1300	None	62	Human	Binding	pAC50	=	8.2	8.2	-12	50	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	2913	1300	None	62	Human	Binding	pAC50	=	8.2	8.2	-12	50	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	765	1300	None	62	Human	Binding	pAC50	=	8.2	8.2	-12	50	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL516	1300	None	62	Human	Binding	pAC50	=	8.2	8.2	-12	50	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB00434	1300	None	62	Human	Binding	pAC50	=	8.2	8.2	-12	50	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	2710	84306	None	31	Human	Binding	pAC50	=	6.3	6.3	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL22150	84306	None	31	Human	Binding	pAC50	=	6.3	6.3	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	DB08936	84306	None	31	Human	Binding	pAC50	=	6.3	6.3	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	4921596	98780	None	90	Human	Binding	pAC50	=	5.3	5.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
	60063	98780	None	90	Human	Binding	pAC50	=	5.3	5.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
	CHEMBL278255	98780	None	90	Human	Binding	pAC50	=	5.3	5.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
	3601	14501	None	9	Human	Binding	pAC50	=	6.3	6.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1201349	14501	None	9	Human	Binding	pAC50	=	6.3	6.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
	16351	102728	None	47	Human	Binding	pAC50	=	6.3	6.3	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102728	None	47	Human	Binding	pAC50	=	6.3	6.3	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	DB13256	102728	None	47	Human	Binding	pAC50	=	6.3	6.3	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	1210	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	917	None	51	Human	Binding	pAC50	=	5.3	5.3	-257	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	5039	63181	None	17	Human	Binding	pAC50	=	5.3	5.3	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	CHEMBL1790041	63181	None	17	Human	Binding	pAC50	=	5.3	5.3	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	DB00863	63181	None	17	Human	Binding	pAC50	=	5.3	5.3	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	2337	3254	None	77	Human	Binding	pAC50	=	5.3	5.3	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3254	None	77	Human	Binding	pAC50	=	5.3	5.3	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3254	None	77	Human	Binding	pAC50	=	5.3	5.3	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3254	None	77	Human	Binding	pAC50	=	5.3	5.3	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3254	None	77	Human	Binding	pAC50	=	5.3	5.3	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	3158	56265	None	27	Human	Binding	pAC50	=	6.3	6.3	-630	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56265	None	27	Human	Binding	pAC50	=	6.3	6.3	-630	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	DB01142	56265	None	27	Human	Binding	pAC50	=	6.3	6.3	-630	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	135565596	109267	None	70	Human	Binding	pAC50	=	5.3	5.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	2	11	0.7	COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21	10.1038/s41467-023-40064-9
	CHEMBL3218576	109267	None	70	Human	Binding	pAC50	=	5.3	5.3	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	2	11	0.7	COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21	10.1038/s41467-023-40064-9
	2107	3053	None	50	Human	Binding	pAC50	=	5.2	5.2	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	4747	3053	None	50	Human	Binding	pAC50	=	5.2	5.2	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	9216	3053	None	50	Human	Binding	pAC50	=	5.2	5.2	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL251940	3053	None	50	Human	Binding	pAC50	=	5.2	5.2	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB01608	3053	None	50	Human	Binding	pAC50	=	5.2	5.2	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	3158	56265	None	27	Human	Binding	pAC50	=	6.2	6.2	-630	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56265	None	27	Human	Binding	pAC50	=	6.2	6.2	-630	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	DB01142	56265	None	27	Human	Binding	pAC50	=	6.2	6.2	-630	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	2220	3132	None	82	Human	Binding	pAC50	=	7.2	7.2	-	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3132	None	82	Human	Binding	pAC50	=	7.2	7.2	-	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3132	None	82	Human	Binding	pAC50	=	7.2	7.2	-	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3132	None	82	Human	Binding	pAC50	=	7.2	7.2	-	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3132	None	82	Human	Binding	pAC50	=	7.2	7.2	-	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	5568	197498	None	29	Human	Binding	pAC50	=	6.2	6.2	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	66069	197498	None	29	Human	Binding	pAC50	=	6.2	6.2	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	CHEMBL1201102	197498	None	29	Human	Binding	pAC50	=	6.2	6.2	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	CHEMBL570	197498	None	29	Human	Binding	pAC50	=	6.2	6.2	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	DB00508	197498	None	29	Human	Binding	pAC50	=	6.2	6.2	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	11976	919	None	59	Human	Binding	pAC50	=	7.2	7.2	-23	24	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	667467	919	None	59	Human	Binding	pAC50	=	7.2	7.2	-23	24	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	CHEMBL908	919	None	59	Human	Binding	pAC50	=	7.2	7.2	-23	24	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	DB01239	919	None	59	Human	Binding	pAC50	=	7.2	7.2	-23	24	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	3162	4233	None	43	Human	Binding	pAC50	=	5.2	5.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	6	0	3	2.9	CN(C)CCOC(C)(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1004	4233	None	43	Human	Binding	pAC50	=	5.2	5.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	6	0	3	2.9	CN(C)CCOC(C)(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	DB00366	4233	None	43	Human	Binding	pAC50	=	5.2	5.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	6	0	3	2.9	CN(C)CCOC(C)(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	5328940	100214	None	107	Human	Binding	pAC50	=	5.2	5.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL288441	100214	None	107	Human	Binding	pAC50	=	5.2	5.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	21722	17990	None	31	Human	Binding	pAC50	=	6.2	6.2	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17990	None	31	Human	Binding	pAC50	=	6.2	6.2	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	3336	94999	None	30	Human	Binding	pAC50	=	5.2	5.2	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1405922	94999	None	30	Human	Binding	pAC50	=	5.2	5.2	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL254832	94999	None	30	Human	Binding	pAC50	=	5.2	5.2	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	1273	1752	None	16	Human	Binding	pAC50	=	5.2	5.2	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	3450	1752	None	16	Human	Binding	pAC50	=	5.2	5.2	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	356	1752	None	16	Human	Binding	pAC50	=	5.2	5.2	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	6172	1752	None	16	Human	Binding	pAC50	=	5.2	5.2	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	67425	1752	None	16	Human	Binding	pAC50	=	5.2	5.2	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	CHEMBL360055	1752	None	16	Human	Binding	pAC50	=	5.2	5.2	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	DB00483	1752	None	16	Human	Binding	pAC50	=	5.2	5.2	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	2905	14496	None	50	Human	Binding	pAC50	=	6.2	6.2	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1201338	14496	None	50	Human	Binding	pAC50	=	6.2	6.2	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	DB00979	14496	None	50	Human	Binding	pAC50	=	6.2	6.2	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	65863	14463	None	57	Human	Binding	pAC50	=	5.2	5.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1201196	14463	None	57	Human	Binding	pAC50	=	5.2	5.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
	2774	3866	None	95	Human	Binding	pAC50	=	6.2	6.2	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593	3866	None	95	Human	Binding	pAC50	=	6.2	6.2	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	7319	3866	None	95	Human	Binding	pAC50	=	6.2	6.2	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	CHEMBL1200604	3866	None	95	Human	Binding	pAC50	=	6.2	6.2	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB00809	3866	None	95	Human	Binding	pAC50	=	6.2	6.2	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB01199	3866	None	95	Human	Binding	pAC50	=	6.2	6.2	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	2865	4141	None	73	Human	Binding	pAC50	=	5.2	5.2	-1659	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4141	None	73	Human	Binding	pAC50	=	5.2	5.2	-1659	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4141	None	73	Human	Binding	pAC50	=	5.2	5.2	-1659	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4141	None	73	Human	Binding	pAC50	=	5.2	5.2	-1659	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4141	None	73	Human	Binding	pAC50	=	5.2	5.2	-1659	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	1935	3732	None	97	Human	Binding	pAC50	=	5.2	5.2	-977	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
	2551	3732	None	97	Human	Binding	pAC50	=	5.2	5.2	-977	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
	6687	3732	None	97	Human	Binding	pAC50	=	5.2	5.2	-977	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL95	3732	None	97	Human	Binding	pAC50	=	5.2	5.2	-977	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00382	3732	None	97	Human	Binding	pAC50	=	5.2	5.2	-977	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
	1971	2864	None	38	Human	Binding	pAC50	=	6.2	6.2	-9	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2864	None	38	Human	Binding	pAC50	=	6.2	6.2	-9	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2864	None	38	Human	Binding	pAC50	=	6.2	6.2	-9	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2864	None	38	Human	Binding	pAC50	=	6.2	6.2	-9	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2864	None	38	Human	Binding	pAC50	=	6.2	6.2	-9	30	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	3157	1469	None	71	Human	Binding	pAC50	=	5.2	5.2	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1469	None	71	Human	Binding	pAC50	=	5.2	5.2	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1469	None	71	Human	Binding	pAC50	=	5.2	5.2	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1469	None	71	Human	Binding	pAC50	=	5.2	5.2	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1469	None	71	Human	Binding	pAC50	=	5.2	5.2	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	2600	3777	None	74	Human	Binding	pAC50	=	5.2	5.2	-	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3777	None	74	Human	Binding	pAC50	=	5.2	5.2	-	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3777	None	74	Human	Binding	pAC50	=	5.2	5.2	-	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3777	None	74	Human	Binding	pAC50	=	5.2	5.2	-	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3777	None	74	Human	Binding	pAC50	=	5.2	5.2	-	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	19861	207521	None	50	Human	Binding	pAC50	=	7.2	7.2	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	207521	None	50	Human	Binding	pAC50	=	7.2	7.2	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	DB00719	207521	None	50	Human	Binding	pAC50	=	7.2	7.2	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	4976	203577	None	29	Human	Binding	pAC50	=	6.2	6.2	-1	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	203577	None	29	Human	Binding	pAC50	=	6.2	6.2	-1	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	135409453	3771	None	41	Human	Binding	pAC50	=	5.2	5.2	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3771	None	41	Human	Binding	pAC50	=	5.2	5.2	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3771	None	41	Human	Binding	pAC50	=	5.2	5.2	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	448537	160248	None	89	Human	Binding	pAC50	=	5.2	5.2	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160248	None	89	Human	Binding	pAC50	=	5.2	5.2	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	71329	179267	None	102	Human	Binding	pAC50	=	5.2	5.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	11	2	6	2.0	CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL473	179267	None	102	Human	Binding	pAC50	=	5.2	5.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	11	2	6	2.0	CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	27901	78205	None	22	Human	Binding	pAC50	=	6.2	6.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2105458	78205	None	22	Human	Binding	pAC50	=	6.2	6.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4822	45030	None	47	Human	Binding	pAC50	=	8.2	8.2	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL152408	45030	None	47	Human	Binding	pAC50	=	8.2	8.2	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
	26987	948	None	33	Human	Binding	pAC50	=	7.2	7.2	-102	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	948	None	33	Human	Binding	pAC50	=	7.2	7.2	-102	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	948	None	33	Human	Binding	pAC50	=	7.2	7.2	-102	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	948	None	33	Human	Binding	pAC50	=	7.2	7.2	-102	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	948	None	33	Human	Binding	pAC50	=	7.2	7.2	-102	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	3236	67607	None	43	Human	Binding	pAC50	=	5.2	5.2	1	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1902981	67607	None	43	Human	Binding	pAC50	=	5.2	5.2	1	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	1371	1921	None	11	Human	Binding	pAC50	=	7.1	7.1	-4	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
	24199	1921	None	11	Human	Binding	pAC50	=	7.1	7.1	-4	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
	323	1921	None	11	Human	Binding	pAC50	=	7.1	7.1	-4	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1201325	1921	None	11	Human	Binding	pAC50	=	7.1	7.1	-4	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
	DB06787	1921	None	11	Human	Binding	pAC50	=	7.1	7.1	-4	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
	3047788	78194	None	15	Human	Binding	pAC50	=	5.2	5.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL2105148	78194	None	15	Human	Binding	pAC50	=	5.2	5.2	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
	2865	4141	None	73	Human	Binding	pAC50	=	5.2	5.2	-1659	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4141	None	73	Human	Binding	pAC50	=	5.2	5.2	-1659	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4141	None	73	Human	Binding	pAC50	=	5.2	5.2	-1659	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4141	None	73	Human	Binding	pAC50	=	5.2	5.2	-1659	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4141	None	73	Human	Binding	pAC50	=	5.2	5.2	-1659	54	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	5329102	194724	None	86	Human	Binding	pAC50	=	5.1	5.1	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194724	None	86	Human	Binding	pAC50	=	5.1	5.1	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	135398737	957	None	93	Human	Binding	pAC50	=	6.1	6.1	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	957	None	93	Human	Binding	pAC50	=	6.1	6.1	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	957	None	93	Human	Binding	pAC50	=	6.1	6.1	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	957	None	93	Human	Binding	pAC50	=	6.1	6.1	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	957	None	93	Human	Binding	pAC50	=	6.1	6.1	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	1613	2346	None	53	Human	Binding	pAC50	=	6.1	6.1	-42	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2346	None	53	Human	Binding	pAC50	=	6.1	6.1	-42	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2346	None	53	Human	Binding	pAC50	=	6.1	6.1	-42	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2346	None	53	Human	Binding	pAC50	=	6.1	6.1	-42	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2346	None	53	Human	Binding	pAC50	=	6.1	6.1	-42	45	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	115368	3054	None	47	Human	Binding	pAC50	=	5.1	5.1	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	2112	3054	None	47	Human	Binding	pAC50	=	5.1	5.1	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	7556	3054	None	47	Human	Binding	pAC50	=	5.1	5.1	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1472975	3054	None	47	Human	Binding	pAC50	=	5.1	5.1	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	DB08922	3054	None	47	Human	Binding	pAC50	=	5.1	5.1	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	124087	1388	None	114	Human	Binding	pAC50	=	7.1	7.1	-6	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1388	None	114	Human	Binding	pAC50	=	7.1	7.1	-6	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1388	None	114	Human	Binding	pAC50	=	7.1	7.1	-6	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1388	None	114	Human	Binding	pAC50	=	7.1	7.1	-6	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1388	None	114	Human	Binding	pAC50	=	7.1	7.1	-6	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	1979	77324	None	70	Human	Binding	pAC50	=	5.1	5.1	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL20835	77324	None	70	Human	Binding	pAC50	=	5.1	5.1	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	12488	1655	None	56	Human	Binding	pAC50	=	5.1	5.1	-	23	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	941361	1655	None	56	Human	Binding	pAC50	=	5.1	5.1	-	23	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	CHEMBL30008	1655	None	56	Human	Binding	pAC50	=	5.1	5.1	-	23	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	DB04841	1655	None	56	Human	Binding	pAC50	=	5.1	5.1	-	23	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	3033538	1318	None	39	Human	Binding	pAC50	=	5.1	5.1	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	7155	1318	None	39	Human	Binding	pAC50	=	5.1	5.1	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	781	1318	None	39	Human	Binding	pAC50	=	5.1	5.1	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1201216	1318	None	39	Human	Binding	pAC50	=	5.1	5.1	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	DB00298	1318	None	39	Human	Binding	pAC50	=	5.1	5.1	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	237	204863	None	48	Human	Binding	pAC50	=	6.1	6.1	-1	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL546257	204863	None	48	Human	Binding	pAC50	=	6.1	6.1	-1	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL554190	204863	None	48	Human	Binding	pAC50	=	6.1	6.1	-1	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL7568	204863	None	48	Human	Binding	pAC50	=	6.1	6.1	-1	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	21855	84244	None	42	Human	Binding	pAC50	=	7.1	7.1	-7	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL22108	84244	None	42	Human	Binding	pAC50	=	7.1	7.1	-7	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
	DB08801	84244	None	42	Human	Binding	pAC50	=	7.1	7.1	-7	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
	2771	195015	None	74	Human	Binding	pAC50	=	5.1	5.1	-	27	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	195015	None	74	Human	Binding	pAC50	=	5.1	5.1	-	27	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	195015	None	74	Human	Binding	pAC50	=	5.1	5.1	-	27	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	34040	28083	None	72	Human	Binding	pAC50	=	5.1	5.1	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	CHEMBL1372950	28083	None	72	Human	Binding	pAC50	=	5.1	5.1	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	DB00699	28083	None	72	Human	Binding	pAC50	=	5.1	5.1	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	6834	205550	None	45	Human	Binding	pAC50	=	5.1	5.1	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL811	205550	None	45	Human	Binding	pAC50	=	5.1	5.1	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	DB00835	205550	None	45	Human	Binding	pAC50	=	5.1	5.1	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	3000322	3560	None	38	Human	Binding	pAC50	=	8.1	8.1	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3560	None	38	Human	Binding	pAC50	=	8.1	8.1	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3560	None	38	Human	Binding	pAC50	=	8.1	8.1	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3560	None	38	Human	Binding	pAC50	=	8.1	8.1	-5	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	2705	3840	None	64	Human	Binding	pAC50	=	8.1	8.1	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3840	None	64	Human	Binding	pAC50	=	8.1	8.1	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3840	None	64	Human	Binding	pAC50	=	8.1	8.1	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3840	None	64	Human	Binding	pAC50	=	8.1	8.1	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3840	None	64	Human	Binding	pAC50	=	8.1	8.1	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	2705	3840	None	64	Human	Binding	pAC50	=	8.1	8.1	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3840	None	64	Human	Binding	pAC50	=	8.1	8.1	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3840	None	64	Human	Binding	pAC50	=	8.1	8.1	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3840	None	64	Human	Binding	pAC50	=	8.1	8.1	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3840	None	64	Human	Binding	pAC50	=	8.1	8.1	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	1605	2340	None	117	Human	Binding	pAC50	=	5.1	5.1	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	3957	2340	None	117	Human	Binding	pAC50	=	5.1	5.1	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	7216	2340	None	117	Human	Binding	pAC50	=	5.1	5.1	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	CHEMBL998	2340	None	117	Human	Binding	pAC50	=	5.1	5.1	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	DB00455	2340	None	117	Human	Binding	pAC50	=	5.1	5.1	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	1224	1431	None	83	Human	Binding	pAC50	=	6.1	6.1	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1431	None	83	Human	Binding	pAC50	=	6.1	6.1	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1431	None	83	Human	Binding	pAC50	=	6.1	6.1	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1431	None	83	Human	Binding	pAC50	=	6.1	6.1	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1431	None	83	Human	Binding	pAC50	=	6.1	6.1	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1431	None	83	Human	Binding	pAC50	=	6.1	6.1	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	2551	793	None	23	Human	Binding	pAC50	=	5.1	5.1	-6	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	298	793	None	23	Human	Binding	pAC50	=	5.1	5.1	-6	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	488	793	None	23	Human	Binding	pAC50	=	5.1	5.1	-6	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL965	793	None	23	Human	Binding	pAC50	=	5.1	5.1	-6	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB00411	793	None	23	Human	Binding	pAC50	=	5.1	5.1	-6	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	2683	102886	None	25	Human	Binding	pAC50	=	6.1	6.1	-5	16	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL305906	102886	None	25	Human	Binding	pAC50	=	6.1	6.1	-5	16	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL334255	102886	None	25	Human	Binding	pAC50	=	6.1	6.1	-5	16	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	135398745	2912	None	112	Human	Binding	pAC50	=	7.1	7.1	-38	66	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2912	None	112	Human	Binding	pAC50	=	7.1	7.1	-38	66	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2912	None	112	Human	Binding	pAC50	=	7.1	7.1	-38	66	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2912	None	112	Human	Binding	pAC50	=	7.1	7.1	-38	66	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	5205	78185	None	58	Human	Binding	pAC50	=	6.1	6.1	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL2104895	78185	None	58	Human	Binding	pAC50	=	6.1	6.1	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
	1227	2487	None	43	Human	Binding	pAC50	=	5.1	5.1	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	2331	2487	None	43	Human	Binding	pAC50	=	5.1	5.1	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	3957	2487	None	43	Human	Binding	pAC50	=	5.1	5.1	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	4992	2487	None	43	Human	Binding	pAC50	=	5.1	5.1	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL511	2487	None	43	Human	Binding	pAC50	=	5.1	5.1	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	DB06691	2487	None	43	Human	Binding	pAC50	=	5.1	5.1	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	2337	3254	None	77	Human	Binding	pAC50	=	6.1	6.1	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3254	None	77	Human	Binding	pAC50	=	6.1	6.1	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3254	None	77	Human	Binding	pAC50	=	6.1	6.1	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3254	None	77	Human	Binding	pAC50	=	6.1	6.1	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3254	None	77	Human	Binding	pAC50	=	6.1	6.1	-31	63	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	1560	2307	None	20	Human	Binding	pAC50	=	5.1	5.1	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
	5359371	2307	None	20	Human	Binding	pAC50	=	5.1	5.1	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
	7209	2307	None	20	Human	Binding	pAC50	=	5.1	5.1	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1254682	2307	None	20	Human	Binding	pAC50	=	5.1	5.1	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
	DB00504	2307	None	20	Human	Binding	pAC50	=	5.1	5.1	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
	1353	1909	None	93	Human	Binding	pAC50	=	5.1	5.1	-5011	86	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1909	None	93	Human	Binding	pAC50	=	5.1	5.1	-5011	86	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1909	None	93	Human	Binding	pAC50	=	5.1	5.1	-5011	86	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1909	None	93	Human	Binding	pAC50	=	5.1	5.1	-5011	86	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1909	None	93	Human	Binding	pAC50	=	5.1	5.1	-5011	86	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2028	2977	None	80	Human	Binding	pAC50	=	8.1	8.1	-8	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	359	2977	None	80	Human	Binding	pAC50	=	8.1	8.1	-8	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	4634	2977	None	80	Human	Binding	pAC50	=	8.1	8.1	-8	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	CHEMBL1231	2977	None	80	Human	Binding	pAC50	=	8.1	8.1	-8	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	DB01062	2977	None	80	Human	Binding	pAC50	=	8.1	8.1	-8	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	1400	1955	None	70	Human	Binding	pAC50	=	5.0	5.0	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1955	None	70	Human	Binding	pAC50	=	5.0	5.0	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1955	None	70	Human	Binding	pAC50	=	5.0	5.0	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1955	None	70	Human	Binding	pAC50	=	5.0	5.0	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1955	None	70	Human	Binding	pAC50	=	5.0	5.0	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1955	None	70	Human	Binding	pAC50	=	5.0	5.0	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	180	401	None	56	Human	Binding	pAC50	=	7.0	7.0	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	56	Human	Binding	pAC50	=	7.0	7.0	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	56	Human	Binding	pAC50	=	7.0	7.0	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	56	Human	Binding	pAC50	=	7.0	7.0	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	56	Human	Binding	pAC50	=	7.0	7.0	-27	40	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	98941	46948	None	17	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL154126	46948	None	17	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	9880	30939	None	61	Human	Binding	pAC50	=	5.0	5.0	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	416	2	0	4	4.6	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL139835	30939	None	61	Human	Binding	pAC50	=	5.0	5.0	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	416	2	0	4	4.6	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	54697325	58977	None	35	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1689772	58977	None	35	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	26987	948	None	33	Human	Binding	pAC50	=	6.0	6.0	-102	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	948	None	33	Human	Binding	pAC50	=	6.0	6.0	-102	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	948	None	33	Human	Binding	pAC50	=	6.0	6.0	-102	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	948	None	33	Human	Binding	pAC50	=	6.0	6.0	-102	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	948	None	33	Human	Binding	pAC50	=	6.0	6.0	-102	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	25102847	78219	None	93	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78219	None	93	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	3055	1432	None	44	Human	Binding	pAC50	=	6.0	6.0	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	313	1432	None	44	Human	Binding	pAC50	=	6.0	6.0	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	7163	1432	None	44	Human	Binding	pAC50	=	6.0	6.0	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL936	1432	None	44	Human	Binding	pAC50	=	6.0	6.0	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	DB01231	1432	None	44	Human	Binding	pAC50	=	6.0	6.0	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	5832	14458	None	54	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	1	0	3	4.1	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL1201146	14458	None	54	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	1	0	3	4.1	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	9417	133510	None	54	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL1524185	133510	None	54	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL370753	133510	None	54	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	135	2530	None	43	Human	Binding	pAC50	=	6.0	6.0	-25	58	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2530	None	43	Human	Binding	pAC50	=	6.0	6.0	-25	58	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2530	None	43	Human	Binding	pAC50	=	6.0	6.0	-25	58	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2530	None	43	Human	Binding	pAC50	=	6.0	6.0	-25	58	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2530	None	43	Human	Binding	pAC50	=	6.0	6.0	-25	58	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1726	2495	None	13	Human	Binding	pAC50	=	5.0	5.0	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	1993	2495	None	13	Human	Binding	pAC50	=	5.0	5.0	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	7438	2495	None	13	Human	Binding	pAC50	=	5.0	5.0	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	CHEMBL978	2495	None	13	Human	Binding	pAC50	=	5.0	5.0	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	DB06709	2495	None	13	Human	Binding	pAC50	=	5.0	5.0	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	2520	204006	None	70	Human	Binding	pAC50	=	5	5.0	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	204006	None	70	Human	Binding	pAC50	=	5	5.0	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	204006	None	70	Human	Binding	pAC50	=	5	5.0	-	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	2284	3180	None	33	Human	Binding	pAC50	=	6	6.0	-21	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3180	None	33	Human	Binding	pAC50	=	6	6.0	-21	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3180	None	33	Human	Binding	pAC50	=	6	6.0	-21	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3180	None	33	Human	Binding	pAC50	=	6	6.0	-21	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3180	None	33	Human	Binding	pAC50	=	6	6.0	-21	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	10104167	2057	None	2	Guinea pig	Binding	pEC50	=	10.1	10.1	-	4	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	6937	2057	None	2	Guinea pig	Binding	pEC50	=	10.1	10.1	-	4	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	CHEMBL3121473	2057	None	2	Guinea pig	Binding	pEC50	=	10.1	10.1	-	4	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	10104167	2057	None	2	Guinea pig	Binding	pEC50	=	9.8	9.8	-	4	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	6937	2057	None	2	Guinea pig	Binding	pEC50	=	9.8	9.8	-	4	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	CHEMBL3121473	2057	None	2	Guinea pig	Binding	pEC50	=	9.8	9.8	-	4	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	405242	11965	None	1	Pig	Binding	pEC50	=	9.3	9.3	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL1182967	11965	None	1	Pig	Binding	pEC50	=	9.3	9.3	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL274413	11965	None	1	Pig	Binding	pEC50	=	9.3	9.3	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	23657685	13817	None	0	Pig	Binding	pEC50	=	9.1	9.1	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1195729	13817	None	0	Pig	Binding	pEC50	=	9.1	9.1	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1203986	13817	None	0	Pig	Binding	pEC50	=	9.1	9.1	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	23657685	13817	None	0	Pig	Binding	pEC50	=	9.1	9.1	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1195729	13817	None	0	Pig	Binding	pEC50	=	9.1	9.1	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1203986	13817	None	0	Pig	Binding	pEC50	=	9.1	9.1	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	44435840	13818	None	0	Pig	Binding	pEC50	=	9	9.0	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1195736	13818	None	0	Pig	Binding	pEC50	=	9	9.0	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL555247	13818	None	0	Pig	Binding	pEC50	=	9	9.0	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	44435840	13818	None	0	Pig	Binding	pEC50	=	9.0	9.0	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1195736	13818	None	0	Pig	Binding	pEC50	=	9.0	9.0	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL555247	13818	None	0	Pig	Binding	pEC50	=	9.0	9.0	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	11600184	12301	None	0	Pig	Binding	pEC50	=	9.0	9.0	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
	CHEMBL1184960	12301	None	0	Pig	Binding	pEC50	=	9.0	9.0	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
	CHEMBL380572	12301	None	0	Pig	Binding	pEC50	=	9.0	9.0	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
	23657683	13746	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1195234	13746	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1203985	13746	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	23657683	13746	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1195234	13746	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1203985	13746	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	44435838	13065	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1190118	13065	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1203984	13065	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	44435838	13065	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1190118	13065	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1203984	13065	None	0	Pig	Binding	pEC50	=	8.9	8.9	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	23657687	13064	None	0	Pig	Binding	pEC50	=	8.8	8.8	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1190117	13064	None	0	Pig	Binding	pEC50	=	8.8	8.8	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL540132	13064	None	0	Pig	Binding	pEC50	=	8.8	8.8	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	23657687	13064	None	0	Pig	Binding	pEC50	=	8.8	8.8	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1190117	13064	None	0	Pig	Binding	pEC50	=	8.8	8.8	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL540132	13064	None	0	Pig	Binding	pEC50	=	8.8	8.8	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	10653182	99137	None	0	Pig	Binding	pEC50	=	6	6.0	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
	CHEMBL265482	99137	None	0	Pig	Binding	pEC50	=	6	6.0	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
	CHEMBL281080	99137	None	0	Pig	Binding	pEC50	=	6	6.0	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
	2370	622	None	31	Guinea pig	Binding	pEC50	=	6	6.0	-	5	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	297	622	None	31	Guinea pig	Binding	pEC50	=	6	6.0	-	5	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	358	622	None	31	Guinea pig	Binding	pEC50	=	6	6.0	-	5	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	CHEMBL1482	622	None	31	Guinea pig	Binding	pEC50	=	6	6.0	-	5	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	DB01019	622	None	31	Guinea pig	Binding	pEC50	=	6	6.0	-	5	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	167962	4067	None	4	Human	Binding	pEC50	=	6	6.0	-	1	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
	362	4067	None	4	Human	Binding	pEC50	=	6	6.0	-	1	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
	CHEMBL31599	4067	None	4	Human	Binding	pEC50	=	6	6.0	-	1	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
	10653182	99137	None	0	Pig	Binding	pEC50	=	6	6.0	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
	CHEMBL265482	99137	None	0	Pig	Binding	pEC50	=	6	6.0	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
	CHEMBL281080	99137	None	0	Pig	Binding	pEC50	=	6	6.0	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
	2166	3121	None	49	Human	Binding	pEC50	=	6	6.0	-34	8	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
	305	3121	None	49	Human	Binding	pEC50	=	6	6.0	-34	8	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
	5910	3121	None	49	Human	Binding	pEC50	=	6	6.0	-34	8	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
	CHEMBL550	3121	None	49	Human	Binding	pEC50	=	6	6.0	-34	8	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
	DB01085	3121	None	49	Human	Binding	pEC50	=	6	6.0	-34	8	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
	10437519	106919	None	0	Pig	Binding	pEC50	=	5	5.0	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	389	12	0	2	3.4	CC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31475	106919	None	0	Pig	Binding	pEC50	=	5	5.0	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	389	12	0	2	3.4	CC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	76328902	106516	None	0	Guinea pig	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121475	106516	None	0	Guinea pig	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140248	106516	None	0	Guinea pig	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL5287096	194611	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
	CHEMBL5315302	194611	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
	44408941	11813	None	0	Human	Binding	pEC50	=	7.0	7.0	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1182020	11813	None	0	Human	Binding	pEC50	=	7.0	7.0	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL206666	11813	None	0	Human	Binding	pEC50	=	7.0	7.0	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	118714969	120841	None	0	Pig	Binding	pEC50	=	8.0	8.0	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	CHEMBL3337859	120841	None	0	Pig	Binding	pEC50	=	8.0	8.0	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	CHEMBL3558417	120841	None	0	Pig	Binding	pEC50	=	8.0	8.0	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	46878254	14236	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1199299	14236	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	CHEMBL607178	14236	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	60138187	106446	None	0	Guinea pig	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	60138192	106446	None	0	Guinea pig	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121479	106446	None	0	Guinea pig	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3139879	106446	None	0	Guinea pig	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	135544402	113106	None	0	Pig	Binding	pEC50	=	5.0	5.0	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	135597270	113106	None	0	Pig	Binding	pEC50	=	5.0	5.0	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL1202147	113106	None	0	Pig	Binding	pEC50	=	5.0	5.0	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL33142	113106	None	0	Pig	Binding	pEC50	=	5.0	5.0	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	11613432	12306	None	0	Human	Binding	pEC50	=	5.0	5.0	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1184988	12306	None	0	Human	Binding	pEC50	=	5.0	5.0	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL382243	12306	None	0	Human	Binding	pEC50	=	5.0	5.0	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	44265572	98670	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL262448	98670	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL27743	98670	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	44265572	98670	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL262448	98670	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL27743	98670	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	10077281	104105	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL30939	104105	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL8653	104105	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	44318743	105947	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	584	0	0	6	4.3	C1=C2CN3CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2C23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/s0960-894x(00)00509-6
	CHEMBL312920	105947	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	584	0	0	6	4.3	C1=C2CN3CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2C23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/s0960-894x(00)00509-6
	118714976	120843	None	0	Pig	Binding	pEC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337863	120843	None	0	Pig	Binding	pEC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558421	120843	None	0	Pig	Binding	pEC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	76328902	106516	None	0	Guinea pig	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121475	106516	None	0	Guinea pig	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140248	106516	None	0	Guinea pig	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	118714976	120843	None	0	Pig	Binding	pEC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337863	120843	None	0	Pig	Binding	pEC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558421	120843	None	0	Pig	Binding	pEC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	187	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	11828809	11956	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL1182934	11956	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL273255	11956	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	134207697	174277	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	428	3	2	7	3.0	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5ccc(F)c(F)c5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	CHEMBL4549515	174277	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	428	3	2	7	3.0	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5ccc(F)c(F)c5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	10438106	99655	None	0	Pig	Binding	pEC50	=	4.9	4.9	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL1202149	99655	None	0	Pig	Binding	pEC50	=	4.9	4.9	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL284370	99655	None	0	Pig	Binding	pEC50	=	4.9	4.9	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	44279262	106072	None	0	Pig	Binding	pEC50	=	4.9	4.9	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	522	16	0	4	3.2	C[C@@H]1C(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)[C@H](C)[C@@H](C)C2=O)C(=O)[C@H]1C	10.1021/jm021077w
	CHEMBL31336	106072	None	0	Pig	Binding	pEC50	=	4.9	4.9	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	522	16	0	4	3.2	C[C@@H]1C(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)[C@H](C)[C@@H](C)C2=O)C(=O)[C@H]1C	10.1021/jm021077w
	10795567	99833	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
	CHEMBL285598	99833	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
	CHEMBL303052	99833	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
	10795567	99833	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
	CHEMBL285598	99833	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
	CHEMBL303052	99833	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
	187	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Binding	pEC50	=	7.9	7.9	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	167962	4067	None	4	Pig	Binding	pEC50	=	7.9	7.9	-	1	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
	362	4067	None	4	Pig	Binding	pEC50	=	7.9	7.9	-	1	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
	CHEMBL31599	4067	None	4	Pig	Binding	pEC50	=	7.9	7.9	-	1	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
	405252	11932	None	3	Pig	Binding	pEC50	=	7.9	7.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL1182747	11932	None	3	Pig	Binding	pEC50	=	7.9	7.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL263972	11932	None	3	Pig	Binding	pEC50	=	7.9	7.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	1273	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	3450	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	356	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	6172	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	67425	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	CHEMBL360055	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	DB00483	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	1273	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	3450	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	356	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	6172	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	67425	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	CHEMBL360055	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	DB00483	1752	None	16	Pig	Binding	pEC50	=	6.9	6.9	-	3	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	168294767	193017	None	0	Human	Binding	pEC50	=	5.9	5.9	-1	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5207281	193017	None	0	Human	Binding	pEC50	=	5.9	5.9	-1	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222802	193017	None	0	Human	Binding	pEC50	=	5.9	5.9	-1	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	10865495	18068	None	0	Human	Binding	pEC50	=	6.9	6.9	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	CHEMBL126655	18068	None	0	Human	Binding	pEC50	=	6.9	6.9	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	CHEMBL8898	18068	None	0	Human	Binding	pEC50	=	6.9	6.9	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	10865495	18068	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL126655	18068	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL8898	18068	None	0	Pig	Binding	pEC50	=	6.9	6.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	167962	4067	None	4	Pig	Binding	pEC50	=	5.9	5.9	-	1	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
	362	4067	None	4	Pig	Binding	pEC50	=	5.9	5.9	-	1	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
	CHEMBL31599	4067	None	4	Pig	Binding	pEC50	=	5.9	5.9	-	1	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
	10699850	100026	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL168760	100026	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL286892	100026	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL5272950	193738	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	166	2	1	3	0.5	O=C1C[C@@H](Cc2cnc[nH]2)CO1	10.1021/acs.jnatprod.2c01079
	10699850	100026	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL168760	100026	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL286892	100026	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	60138189	106518	None	0	Guinea pig	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	60138190	106518	None	0	Guinea pig	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121476	106518	None	0	Guinea pig	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140252	106518	None	0	Guinea pig	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	11007357	11083	None	0	Pig	Binding	pEC50	=	7.9	7.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL1177962	11083	None	0	Pig	Binding	pEC50	=	7.9	7.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL8721	11083	None	0	Pig	Binding	pEC50	=	7.9	7.9	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	10795468	11735	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181455	11735	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL171664	11735	None	0	Pig	Binding	pEC50	=	5.9	5.9	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	170332	160974	None	1	Human	Binding	pEC50	=	4.9	4.9	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Binding	pEC50	=	4.9	4.9	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Binding	pEC50	=	4.9	4.9	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	2370	622	None	31	Guinea pig	Binding	pEC50	=	5.9	5.9	-	5	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	297	622	None	31	Guinea pig	Binding	pEC50	=	5.9	5.9	-	5	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	358	622	None	31	Guinea pig	Binding	pEC50	=	5.9	5.9	-	5	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	CHEMBL1482	622	None	31	Guinea pig	Binding	pEC50	=	5.9	5.9	-	5	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	DB01019	622	None	31	Guinea pig	Binding	pEC50	=	5.9	5.9	-	5	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	167962	4067	None	4	Pig	Binding	pEC50	=	5.9	5.9	-	1	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
	362	4067	None	4	Pig	Binding	pEC50	=	5.9	5.9	-	1	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
	CHEMBL31599	4067	None	4	Pig	Binding	pEC50	=	5.9	5.9	-	1	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
	170332	160974	None	1	Human	Binding	pEC50	=	4.9	4.9	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Binding	pEC50	=	4.9	4.9	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Binding	pEC50	=	4.9	4.9	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	167962	4067	None	4	Pig	Binding	pEC50	=	5.8	5.8	-	1	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	362	4067	None	4	Pig	Binding	pEC50	=	5.8	5.8	-	1	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	CHEMBL31599	4067	None	4	Pig	Binding	pEC50	=	5.8	5.8	-	1	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	405254	106180	None	1	Pig	Binding	pEC50	=	6.8	6.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL269205	106180	None	1	Pig	Binding	pEC50	=	6.8	6.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL31380	106180	None	1	Pig	Binding	pEC50	=	6.8	6.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	167962	4067	None	4	Pig	Binding	pEC50	=	5.8	5.8	-	1	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	362	4067	None	4	Pig	Binding	pEC50	=	5.8	5.8	-	1	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	CHEMBL31599	4067	None	4	Pig	Binding	pEC50	=	5.8	5.8	-	1	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	405254	106180	None	1	Pig	Binding	pEC50	=	6.8	6.8	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL269205	106180	None	1	Pig	Binding	pEC50	=	6.8	6.8	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31380	106180	None	1	Pig	Binding	pEC50	=	6.8	6.8	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	44319261	12343	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	CHEMBL1185324	12343	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	CHEMBL407440	12343	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	10629136	102349	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
	CHEMBL30376	102349	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
	CHEMBL68151	102349	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
	10629136	102349	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
	CHEMBL30376	102349	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
	CHEMBL68151	102349	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
	10985389	11972	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL1183013	11972	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL275988	11972	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	187	255	None	39	Human	Binding	pEC50	=	6.8	6.8	6	9	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	294	255	None	39	Human	Binding	pEC50	=	6.8	6.8	6	9	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	65	255	None	39	Human	Binding	pEC50	=	6.8	6.8	6	9	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	8593	255	None	39	Human	Binding	pEC50	=	6.8	6.8	6	9	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	CHEMBL667	255	None	39	Human	Binding	pEC50	=	6.8	6.8	6	9	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	DB03128	255	None	39	Human	Binding	pEC50	=	6.8	6.8	6	9	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	44408892	75150	None	0	Human	Binding	pEC50	=	4.8	4.8	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL203627	75150	None	0	Human	Binding	pEC50	=	4.8	4.8	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	44265578	17960	None	2	Human	Binding	pEC50	=	6.8	6.8	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL126103	17960	None	2	Human	Binding	pEC50	=	6.8	6.8	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL268194	17960	None	2	Human	Binding	pEC50	=	6.8	6.8	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	44265578	17960	None	2	Pig	Binding	pEC50	=	6.8	6.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL126103	17960	None	2	Pig	Binding	pEC50	=	6.8	6.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL268194	17960	None	2	Pig	Binding	pEC50	=	6.8	6.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	137629935	161018	None	0	Human	Binding	pEC50	=	4.8	4.8	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Binding	pEC50	=	4.8	4.8	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Binding	pEC50	=	4.8	4.8	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	10257778	116781	None	0	Pig	Binding	pEC50	=	4.8	4.8	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL1202150	116781	None	0	Pig	Binding	pEC50	=	4.8	4.8	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL33774	116781	None	0	Pig	Binding	pEC50	=	4.8	4.8	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	137629935	161018	None	0	Human	Binding	pEC50	=	4.8	4.8	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Binding	pEC50	=	4.8	4.8	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Binding	pEC50	=	4.8	4.8	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	44318815	12349	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL1185416	12349	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL412670	12349	None	0	Pig	Binding	pEC50	=	5.8	5.8	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	10974720	17983	None	0	Human	Binding	pEC50	=	6.8	6.8	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	CHEMBL126199	17983	None	0	Human	Binding	pEC50	=	6.8	6.8	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	CHEMBL9071	17983	None	0	Human	Binding	pEC50	=	6.8	6.8	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	10974720	17983	None	0	Pig	Binding	pEC50	=	6.8	6.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL126199	17983	None	0	Pig	Binding	pEC50	=	6.8	6.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL9071	17983	None	0	Pig	Binding	pEC50	=	6.8	6.8	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	76325356	106510	None	0	Guinea pig	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3120178	106510	None	0	Guinea pig	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140233	106510	None	0	Guinea pig	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	405246	11967	None	1	Pig	Binding	pEC50	=	7.7	7.7	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL1182976	11967	None	1	Pig	Binding	pEC50	=	7.7	7.7	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL274564	11967	None	1	Pig	Binding	pEC50	=	7.7	7.7	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	302	2975	None	25	Human	Binding	pEC50	=	7.7	7.7	-34	8	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
	4630	2975	None	25	Human	Binding	pEC50	=	7.7	7.7	-34	8	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
	CHEMBL7634	2975	None	25	Human	Binding	pEC50	=	7.7	7.7	-34	8	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
	187	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	10676698	11734	None	0	Pig	Binding	pEC50	=	5.7	5.7	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181450	11734	None	0	Pig	Binding	pEC50	=	5.7	5.7	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL171388	11734	None	0	Pig	Binding	pEC50	=	5.7	5.7	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	187	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Binding	pEC50	=	5.7	5.7	6	9	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	10604576	105326	None	0	Pig	Binding	pEC50	=	5.7	5.7	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
	CHEMBL303002	105326	None	0	Pig	Binding	pEC50	=	5.7	5.7	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31162	105326	None	0	Pig	Binding	pEC50	=	5.7	5.7	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
	10604576	105326	None	0	Pig	Binding	pEC50	=	5.7	5.7	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
	CHEMBL303002	105326	None	0	Pig	Binding	pEC50	=	5.7	5.7	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
	CHEMBL31162	105326	None	0	Pig	Binding	pEC50	=	5.7	5.7	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
	21158560	112791	None	7	Pig	Binding	pEC50	=	8.7	8.7	-	4	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3305985	112791	None	7	Pig	Binding	pEC50	=	8.7	8.7	-	4	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	11527805	12305	None	0	Pig	Binding	pEC50	=	8.6	8.6	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
	CHEMBL1184985	12305	None	0	Pig	Binding	pEC50	=	8.6	8.6	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
	CHEMBL381913	12305	None	0	Pig	Binding	pEC50	=	8.6	8.6	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
	11535022	11805	None	0	Pig	Binding	pEC50	=	8.6	8.6	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
	CHEMBL1181943	11805	None	0	Pig	Binding	pEC50	=	8.6	8.6	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
	CHEMBL199636	11805	None	0	Pig	Binding	pEC50	=	8.6	8.6	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
	60138188	106448	None	0	Guinea pig	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	60138191	106448	None	0	Guinea pig	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121478	106448	None	0	Guinea pig	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3139897	106448	None	0	Guinea pig	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	44265574	11085	None	0	Pig	Binding	pEC50	=	6.7	6.7	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL1177964	11085	None	0	Pig	Binding	pEC50	=	6.7	6.7	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL8764	11085	None	0	Pig	Binding	pEC50	=	6.7	6.7	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	405250	11837	None	1	Pig	Binding	pEC50	=	6.7	6.7	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
	CHEMBL1182178	11837	None	1	Pig	Binding	pEC50	=	6.7	6.7	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
	CHEMBL216974	11837	None	1	Pig	Binding	pEC50	=	6.7	6.7	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
	76328904	106449	None	0	Guinea pig	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3121480	106449	None	0	Guinea pig	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3139898	106449	None	0	Guinea pig	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	11585610	12307	None	0	Pig	Binding	pEC50	=	7.7	7.7	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL1184995	12307	None	0	Pig	Binding	pEC50	=	7.7	7.7	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL382659	12307	None	0	Pig	Binding	pEC50	=	7.7	7.7	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	11757557	100111	None	0	Pig	Binding	pEC50	=	4.7	4.7	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
	CHEMBL1202151	100111	None	0	Pig	Binding	pEC50	=	4.7	4.7	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
	CHEMBL287536	100111	None	0	Pig	Binding	pEC50	=	4.7	4.7	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
	44279470	102323	None	0	Pig	Binding	pEC50	=	5.7	5.7	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	570	16	0	4	3.8	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O	10.1021/jm021077w
	CHEMBL30361	102323	None	0	Pig	Binding	pEC50	=	5.7	5.7	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	570	16	0	4	3.8	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O	10.1021/jm021077w
	11094083	11086	None	0	Pig	Binding	pEC50	=	6.6	6.6	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
	CHEMBL1177968	11086	None	0	Pig	Binding	pEC50	=	6.6	6.6	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
	CHEMBL8855	11086	None	0	Pig	Binding	pEC50	=	6.6	6.6	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
	11613432	12306	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1184988	12306	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL382243	12306	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	10747747	99075	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
	CHEMBL280535	99075	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
	CHEMBL304129	99075	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
	10747747	99075	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
	CHEMBL280535	99075	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
	CHEMBL304129	99075	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
	44408941	11813	None	0	Human	Binding	pEC50	=	5.6	5.6	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1182020	11813	None	0	Human	Binding	pEC50	=	5.6	5.6	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL206666	11813	None	0	Human	Binding	pEC50	=	5.6	5.6	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	10483419	111344	None	0	Pig	Binding	pEC50	=	4.6	4.6	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL32689	111344	None	0	Pig	Binding	pEC50	=	4.6	4.6	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL539621	111344	None	0	Pig	Binding	pEC50	=	4.6	4.6	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	10771150	11736	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181457	11736	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL171776	11736	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	44278967	99768	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	549	15	0	5	3.5	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL285136	99768	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	549	15	0	5	3.5	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	137629935	161018	None	0	Human	Binding	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Binding	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Binding	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	44279153	107009	None	0	Pig	Binding	pEC50	=	4.6	4.6	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	333	10	1	3	2.3	C[N+](C)(CCCCCCO)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31533	107009	None	0	Pig	Binding	pEC50	=	4.6	4.6	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	333	10	1	3	2.3	C[N+](C)(CCCCCCO)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	137629935	161018	None	0	Human	Binding	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Binding	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Binding	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	2230	465	None	60	Human	Binding	pEC50	=	7.6	7.6	-75	10	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
	296	465	None	60	Human	Binding	pEC50	=	7.6	7.6	-75	10	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
	CHEMBL7303	465	None	60	Human	Binding	pEC50	=	7.6	7.6	-75	10	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
	DB04365	465	None	60	Human	Binding	pEC50	=	7.6	7.6	-75	10	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
	9987754	11079	None	0	Pig	Binding	pEC50	=	7.6	7.6	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL1177947	11079	None	0	Pig	Binding	pEC50	=	7.6	7.6	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL8449	11079	None	0	Pig	Binding	pEC50	=	7.6	7.6	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	10007510	109693	None	0	Pig	Binding	pEC50	=	4.6	4.6	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL1202152	109693	None	0	Pig	Binding	pEC50	=	4.6	4.6	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL32278	109693	None	0	Pig	Binding	pEC50	=	4.6	4.6	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL5287159	194617	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	560	13	1	4	4.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[n+]1c[nH]c(CC2COC(=O)C2)c1	10.1021/acs.jnatprod.2c01079
	CHEMBL5315392	194617	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	560	13	1	4	4.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[n+]1c[nH]c(CC2COC(=O)C2)c1	10.1021/acs.jnatprod.2c01079
	118714979	120844	None	0	Pig	Binding	pEC50	=	6.6	6.6	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337866	120844	None	0	Pig	Binding	pEC50	=	6.6	6.6	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558422	120844	None	0	Pig	Binding	pEC50	=	6.6	6.6	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	10319023	111341	None	0	Pig	Binding	pEC50	=	4.6	4.6	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	323	6	0	2	4.2	CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL32688	111341	None	0	Pig	Binding	pEC50	=	4.6	4.6	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	323	6	0	2	4.2	CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	118714979	120844	None	0	Pig	Binding	pEC50	=	6.6	6.6	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337866	120844	None	0	Pig	Binding	pEC50	=	6.6	6.6	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558422	120844	None	0	Pig	Binding	pEC50	=	6.6	6.6	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	10770828	107589	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL165814	107589	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL31895	107589	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	10770828	107589	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL165814	107589	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31895	107589	None	0	Pig	Binding	pEC50	=	5.6	5.6	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	154734599	2501	None	12	Pig	Binding	pEC50	=	5.5	5.5	-	12	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
	327	2501	None	12	Pig	Binding	pEC50	=	5.5	5.5	-	12	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
	4108	2501	None	12	Pig	Binding	pEC50	=	5.5	5.5	-	12	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
	CHEMBL27673	2501	None	12	Pig	Binding	pEC50	=	5.5	5.5	-	12	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
	44319052	12068	None	0	Pig	Binding	pEC50	=	8.5	8.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL1183674	12068	None	0	Pig	Binding	pEC50	=	8.5	8.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL311649	12068	None	0	Pig	Binding	pEC50	=	8.5	8.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	44319054	12072	None	0	Pig	Binding	pEC50	=	7.5	7.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL1183713	12072	None	0	Pig	Binding	pEC50	=	7.5	7.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL314491	12072	None	0	Pig	Binding	pEC50	=	7.5	7.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	11115491	11923	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL1182715	11923	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL262449	11923	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
	44265538	11087	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL1177969	11087	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL8900	11087	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	2520	204006	None	70	Pig	Binding	pEC50	=	4.5	4.5	-	12	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
	CHEMBL1280	204006	None	70	Pig	Binding	pEC50	=	4.5	4.5	-	12	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
	CHEMBL6966	204006	None	70	Pig	Binding	pEC50	=	4.5	4.5	-	12	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
	118720626	120850	None	0	Pig	Binding	pEC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3355097	120850	None	0	Pig	Binding	pEC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558555	120850	None	0	Pig	Binding	pEC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	44318760	12339	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL1185295	12339	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL405691	12339	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	44279242	105580	None	0	Pig	Binding	pEC50	=	4.5	4.5	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	494	16	0	4	2.7	CC1CC(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)CC(C)C2=O)C1=O	10.1021/jm021077w
	CHEMBL31221	105580	None	0	Pig	Binding	pEC50	=	4.5	4.5	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	494	16	0	4	2.7	CC1CC(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)CC(C)C2=O)C1=O	10.1021/jm021077w
	118720626	120850	None	0	Pig	Binding	pEC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3355097	120850	None	0	Pig	Binding	pEC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558555	120850	None	0	Pig	Binding	pEC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	118714974	120842	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337862	120842	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558420	120842	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	44265563	99858	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
	CHEMBL285811	99858	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
	CHEMBL8491	99858	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
	44265563	99858	None	0	Human	Binding	pEC50	=	6.5	6.5	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL285811	99858	None	0	Human	Binding	pEC50	=	6.5	6.5	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL8491	99858	None	0	Human	Binding	pEC50	=	6.5	6.5	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	118714974	120842	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337862	120842	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558420	120842	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	44265563	99858	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL285811	99858	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL8491	99858	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	118714971	120837	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
	CHEMBL3337860	120837	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
	CHEMBL3558367	120837	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
	44319263	12352	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
	CHEMBL1185419	12352	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
	CHEMBL412718	12352	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
	10556700	12237	None	0	Pig	Binding	pEC50	=	5.5	5.5	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1184494	12237	None	0	Pig	Binding	pEC50	=	5.5	5.5	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL352356	12237	None	0	Pig	Binding	pEC50	=	5.5	5.5	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10843180	11731	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181400	11731	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL169638	11731	None	0	Pig	Binding	pEC50	=	6.5	6.5	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	118714981	120845	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337867	120845	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558423	120845	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	11828771	16736	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL124330	16736	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL8729	16736	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	118714981	120845	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337867	120845	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558423	120845	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	11115442	12340	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL1185309	12340	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL406431	12340	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	11828771	16736	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL124330	16736	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL8729	16736	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	168057	1211	None	11	Pig	Binding	pEC50	=	6.4	6.4	-	1	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	7634	1211	None	11	Pig	Binding	pEC50	=	6.4	6.4	-	1	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	CHEMBL28407	1211	None	11	Pig	Binding	pEC50	=	6.4	6.4	-	1	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	44318758	12315	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL1185047	12315	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL385915	12315	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	76321739	106447	None	0	Guinea pig	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3121477	106447	None	0	Guinea pig	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3139896	106447	None	0	Guinea pig	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	10699593	99411	None	0	Pig	Binding	pEC50	=	5.4	5.4	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL282782	99411	None	0	Pig	Binding	pEC50	=	5.4	5.4	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL353262	99411	None	0	Pig	Binding	pEC50	=	5.4	5.4	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	10699593	99411	None	0	Pig	Binding	pEC50	=	5.4	5.4	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL282782	99411	None	0	Pig	Binding	pEC50	=	5.4	5.4	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL353262	99411	None	0	Pig	Binding	pEC50	=	5.4	5.4	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	168057	1211	None	11	Pig	Binding	pEC50	=	6.4	6.4	-	1	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	7634	1211	None	11	Pig	Binding	pEC50	=	6.4	6.4	-	1	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	CHEMBL28407	1211	None	11	Pig	Binding	pEC50	=	6.4	6.4	-	1	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	44279691	99739	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	664	15	0	4	5.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)CC2c3ccccc3C(C1=O)c1ccccc12)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL284962	99739	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	664	15	0	4	5.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)CC2c3ccccc3C(C1=O)c1ccccc12)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	10909212	12369	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
	CHEMBL1185516	12369	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
	CHEMBL418702	12369	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
	44319178	12405	None	0	Pig	Binding	pEC50	=	8.4	8.4	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL1185797	12405	None	0	Pig	Binding	pEC50	=	8.4	8.4	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL433343	12405	None	0	Pig	Binding	pEC50	=	8.4	8.4	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	405242	11965	None	1	Pig	Binding	pEC50	=	8.4	8.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL1182967	11965	None	1	Pig	Binding	pEC50	=	8.4	8.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL274413	11965	None	1	Pig	Binding	pEC50	=	8.4	8.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	23657556	13063	None	0	Pig	Binding	pEC50	=	8.3	8.3	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1190116	13063	None	0	Pig	Binding	pEC50	=	8.3	8.3	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL540131	13063	None	0	Pig	Binding	pEC50	=	8.3	8.3	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	118714972	114587	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
	CHEMBL3337861	114587	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
	10442337	203946	None	2	Human	Binding	pEC50	=	7.4	7.4	-	0	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	182	2	1	4	1.1	CCOc1noc2c1CNCCC2	10.1021/jm00012a019
	CHEMBL69305	203946	None	2	Human	Binding	pEC50	=	7.4	7.4	-	0	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	182	2	1	4	1.1	CCOc1noc2c1CNCCC2	10.1021/jm00012a019
	118714972	114587	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
	CHEMBL3337861	114587	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
	10461289	112702	None	0	Pig	Binding	pEC50	=	5.4	5.4	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL1202148	112702	None	0	Pig	Binding	pEC50	=	5.4	5.4	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL33044	112702	None	0	Pig	Binding	pEC50	=	5.4	5.4	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	10442081	102606	None	9	Human	Binding	pEC50	=	7.4	7.4	-	0	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	168	1	1	4	0.7	COc1noc2c1CNCCC2	10.1021/jm00012a019
	CHEMBL304142	102606	None	9	Human	Binding	pEC50	=	7.4	7.4	-	0	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	168	1	1	4	0.7	COc1noc2c1CNCCC2	10.1021/jm00012a019
	168927	140167	None	7	Pig	Binding	pEC50	=	6.4	6.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1021/np500259j
	CHEMBL380352	140167	None	7	Pig	Binding	pEC50	=	6.4	6.4	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1021/np500259j
	168927	140167	None	7	Human	Binding	pEC50	=	6.4	6.4	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/j.bmcl.2005.12.030
	CHEMBL380352	140167	None	7	Human	Binding	pEC50	=	6.4	6.4	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/j.bmcl.2005.12.030
	10009514	202167	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	654	17	0	6	7.2	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCCCC1)C1CCCCC1	10.1021/jm021077w
	CHEMBL609382	202167	None	0	Pig	Binding	pEC50	=	7.4	7.4	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	654	17	0	6	7.2	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCCCC1)C1CCCCC1	10.1021/jm021077w
	10974913	11089	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
	CHEMBL1177971	11089	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
	CHEMBL9017	11089	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
	44408892	75150	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL203627	75150	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	44279471	99991	None	0	Pig	Binding	pEC50	=	5.4	5.4	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O	10.1021/jm021077w
	CHEMBL286686	99991	None	0	Pig	Binding	pEC50	=	5.4	5.4	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O	10.1021/jm021077w
	10032676	11730	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181399	11730	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL169633	11730	None	0	Pig	Binding	pEC50	=	6.4	6.4	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10077592	116580	None	1	Pig	Binding	pEC50	=	5.4	5.4	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	458	10	0	4	4.2	CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL33656	116580	None	1	Pig	Binding	pEC50	=	5.4	5.4	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	458	10	0	4	4.2	CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	44265498	111321	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL32676	111321	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL8669	111321	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	44265498	111321	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL32676	111321	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL8669	111321	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	76328904	106449	None	0	Guinea pig	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3121480	106449	None	0	Guinea pig	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3139898	106449	None	0	Guinea pig	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	10009225	96511	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL262632	96511	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL8531	96511	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	10009225	96511	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL262632	96511	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL8531	96511	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	10747449	12244	None	0	Pig	Binding	pEC50	=	5.3	5.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1184538	12244	None	0	Pig	Binding	pEC50	=	5.3	5.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL354750	12244	None	0	Pig	Binding	pEC50	=	5.3	5.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10461019	12238	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1184498	12238	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL352486	12238	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10101670	1508	None	0	Pig	Binding	pEC50	=	5.3	5.3	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
	7635	1508	None	0	Pig	Binding	pEC50	=	5.3	5.3	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
	CHEMBL32985	1508	None	0	Pig	Binding	pEC50	=	5.3	5.3	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
	118720628	120851	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3355098	120851	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558556	120851	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	10509176	12243	None	0	Pig	Binding	pEC50	=	5.3	5.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1184534	12243	None	0	Pig	Binding	pEC50	=	5.3	5.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL354673	12243	None	0	Pig	Binding	pEC50	=	5.3	5.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	118720628	120851	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3355098	120851	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558556	120851	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	23657556	13063	None	0	Pig	Binding	pEC50	=	8.3	8.3	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1190116	13063	None	0	Pig	Binding	pEC50	=	8.3	8.3	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL540131	13063	None	0	Pig	Binding	pEC50	=	8.3	8.3	-	0	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	76325356	106510	None	0	Guinea pig	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3120178	106510	None	0	Guinea pig	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140233	106510	None	0	Guinea pig	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	11505653	12308	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL1185000	12308	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL382846	12308	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	118714977	114588	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
	CHEMBL3337865	114588	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
	118714977	114588	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
	CHEMBL3337865	114588	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
	10963807	11078	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL1177938	11078	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL7902	11078	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	44319265	12342	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL1185319	12342	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL407071	12342	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	10794637	11726	None	0	Pig	Binding	pEC50	=	4.3	4.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181384	11726	None	0	Pig	Binding	pEC50	=	4.3	4.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL169133	11726	None	0	Pig	Binding	pEC50	=	4.3	4.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	44381306	11727	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181388	11727	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL169342	11727	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10843237	12242	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1184525	12242	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL354103	12242	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	11104735	11080	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL1177953	11080	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL8518	11080	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	10676884	11729	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181392	11729	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL169475	11729	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10509365	106879	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31452	106879	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL352323	106879	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	10509365	106879	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL31452	106879	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL352323	106879	None	0	Pig	Binding	pEC50	=	6.3	6.3	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL5285668	194628	None	0	Human	Binding	pEC50	=	6.3	6.3	-	0	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
	CHEMBL5315497	194628	None	0	Human	Binding	pEC50	=	6.3	6.3	-	0	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
	10069369	99702	None	0	Pig	Binding	pEC50	=	4.3	4.3	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	317	9	0	2	3.3	CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL284672	99702	None	0	Pig	Binding	pEC50	=	4.3	4.3	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	317	9	0	2	3.3	CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	10348407	16294	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL122499	16294	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL267482	16294	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	10348407	16294	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL122499	16294	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL267482	16294	None	0	Pig	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	10818763	106985	None	0	Pig	Binding	pEC50	=	6.2	6.2	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL169001	106985	None	0	Pig	Binding	pEC50	=	6.2	6.2	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL31518	106985	None	0	Pig	Binding	pEC50	=	6.2	6.2	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	10818763	106985	None	0	Pig	Binding	pEC50	=	6.2	6.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL169001	106985	None	0	Pig	Binding	pEC50	=	6.2	6.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31518	106985	None	0	Pig	Binding	pEC50	=	6.2	6.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	11422540	202132	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	682	17	0	6	7.8	Cc1ccc2c(c1)C(=O)N(CCCN(CCCCCCN(CCCN1C(=O)c3ccc(C)cc3C1=O)C1CCCCC1)C1CCCCC1)C2=O	10.1021/jm021077w
	CHEMBL609120	202132	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	682	17	0	6	7.8	Cc1ccc2c(c1)C(=O)N(CCCN(CCCCCCN(CCCN1C(=O)c3ccc(C)cc3C1=O)C1CCCCC1)C1CCCCC1)C2=O	10.1021/jm021077w
	10261985	203947	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	192	2	1	4	0.7	C#CCOc1noc2c1CNCCC2	10.1021/jm00012a019
	CHEMBL69306	203947	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	192	2	1	4	0.7	C#CCOc1noc2c1CNCCC2	10.1021/jm00012a019
	11671915	11801	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL1181935	11801	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL197604	11801	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	134207690	174643	None	0	Human	Binding	pEC50	=	6.2	6.2	-	0	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	434	4	2	9	2.4	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cnc(C6CC6)nc5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	CHEMBL4558206	174643	None	0	Human	Binding	pEC50	=	6.2	6.2	-	0	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	434	4	2	9	2.4	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cnc(C6CC6)nc5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	11756054	110862	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	429	9	0	3	5.5	COc1ccc(CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL32609	110862	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	429	9	0	3	5.5	COc1ccc(CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	10747380	104865	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
	CHEMBL31103	104865	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
	CHEMBL68393	104865	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
	10747380	104865	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
	CHEMBL31103	104865	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
	CHEMBL68393	104865	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
	10077281	104105	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL30939	104105	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL8653	104105	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	10509354	11725	None	0	Pig	Binding	pEC50	=	6.2	6.2	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181373	11725	None	0	Pig	Binding	pEC50	=	6.2	6.2	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL168613	11725	None	0	Pig	Binding	pEC50	=	6.2	6.2	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	1935	3732	None	97	Pig	Binding	pEC50	=	5.2	5.2	-	6	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	2551	3732	None	97	Pig	Binding	pEC50	=	5.2	5.2	-	6	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	6687	3732	None	97	Pig	Binding	pEC50	=	5.2	5.2	-	6	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	CHEMBL95	3732	None	97	Pig	Binding	pEC50	=	5.2	5.2	-	6	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	DB00382	3732	None	97	Pig	Binding	pEC50	=	5.2	5.2	-	6	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	11083080	11084	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
	CHEMBL1177963	11084	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
	CHEMBL8763	11084	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
	1935	3732	None	97	Pig	Binding	pEC50	=	5.2	5.2	-	6	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	2551	3732	None	97	Pig	Binding	pEC50	=	5.2	5.2	-	6	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	6687	3732	None	97	Pig	Binding	pEC50	=	5.2	5.2	-	6	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	CHEMBL95	3732	None	97	Pig	Binding	pEC50	=	5.2	5.2	-	6	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	DB00382	3732	None	97	Pig	Binding	pEC50	=	5.2	5.2	-	6	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	53382542	86311	None	0	Rat	Binding	pEC50	=	6.2	6.2	-	0	Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine responsePositive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	CHEMBL2313377	86311	None	0	Rat	Binding	pEC50	=	6.2	6.2	-	0	Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine responsePositive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	134207682	173642	None	0	Human	Binding	pEC50	=	6.2	6.2	-	0	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	461	3	2	8	3.5	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cc(Cl)ncc5Cl)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	CHEMBL4534301	173642	None	0	Human	Binding	pEC50	=	6.2	6.2	-	0	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	461	3	2	8	3.5	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cc(Cl)ncc5Cl)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	10055492	106175	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	CHEMBL31376	106175	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	CHEMBL3350263	106175	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	11504244	106517	None	0	Guinea pig	Binding	pEC50	=	7.2	7.2	-	2	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	60138185	106517	None	0	Guinea pig	Binding	pEC50	=	7.2	7.2	-	2	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121474	106517	None	0	Guinea pig	Binding	pEC50	=	7.2	7.2	-	2	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140249	106517	None	0	Guinea pig	Binding	pEC50	=	7.2	7.2	-	2	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	10055492	106175	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	CHEMBL31376	106175	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	CHEMBL3350263	106175	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	10818794	102165	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
	CHEMBL30264	102165	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
	CHEMBL73114	102165	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
	10818794	102165	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
	CHEMBL30264	102165	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
	CHEMBL73114	102165	None	0	Pig	Binding	pEC50	=	5.2	5.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
	71717892	89076	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	CHEMBL2311018	89076	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	CHEMBL2365146	89076	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	76321739	106447	None	0	Guinea pig	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3121477	106447	None	0	Guinea pig	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3139896	106447	None	0	Guinea pig	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	60138189	106518	None	0	Guinea pig	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	60138190	106518	None	0	Guinea pig	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121476	106518	None	0	Guinea pig	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140252	106518	None	0	Guinea pig	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	60138187	106446	None	0	Guinea pig	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	60138192	106446	None	0	Guinea pig	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121479	106446	None	0	Guinea pig	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3139879	106446	None	0	Guinea pig	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	405244	12341	None	1	Pig	Binding	pEC50	=	8.1	8.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL1185313	12341	None	1	Pig	Binding	pEC50	=	8.1	8.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL406691	12341	None	1	Pig	Binding	pEC50	=	8.1	8.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	60138188	106448	None	0	Guinea pig	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	60138191	106448	None	0	Guinea pig	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121478	106448	None	0	Guinea pig	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3139897	106448	None	0	Guinea pig	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	11768033	11949	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL1182845	11949	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL269592	11949	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	10843266	110561	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
	CHEMBL32530	110561	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
	CHEMBL68936	110561	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
	10985526	18819	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL127933	18819	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL8983	18819	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	10985526	18819	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL127933	18819	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL8983	18819	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	10843266	110561	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
	CHEMBL32530	110561	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
	CHEMBL68936	110561	None	0	Pig	Binding	pEC50	=	7.2	7.2	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
	11353863	202133	None	0	Pig	Binding	pEC50	=	6.1	6.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	596	19	0	8	4.4	N#CCCN(CCCCCCN(CCC#N)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL609124	202133	None	0	Pig	Binding	pEC50	=	6.1	6.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	596	19	0	8	4.4	N#CCCN(CCCCCCN(CCC#N)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	2551	793	None	23	Human	Binding	pEC50	=	7.1	7.1	-6	11	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
	298	793	None	23	Human	Binding	pEC50	=	7.1	7.1	-6	11	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
	488	793	None	23	Human	Binding	pEC50	=	7.1	7.1	-6	11	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
	CHEMBL965	793	None	23	Human	Binding	pEC50	=	7.1	7.1	-6	11	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
	DB00411	793	None	23	Human	Binding	pEC50	=	7.1	7.1	-6	11	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
	132986	99611	None	1	Pig	Binding	pEC50	=	6.1	6.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	702	17	2	4	7.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1c2ccccc2C(=O)NC1c1ccccc1)CCCN1c2ccccc2C(=O)NC1c1ccccc1	10.1021/jm021077w
	CHEMBL284055	99611	None	1	Pig	Binding	pEC50	=	6.1	6.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	702	17	2	4	7.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1c2ccccc2C(=O)NC1c1ccccc1)CCCN1c2ccccc2C(=O)NC1c1ccccc1	10.1021/jm021077w
	405248	11943	None	1	Pig	Binding	pEC50	=	6.1	6.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
	CHEMBL1182821	11943	None	1	Pig	Binding	pEC50	=	6.1	6.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
	CHEMBL268195	11943	None	1	Pig	Binding	pEC50	=	6.1	6.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
	10509706	96438	None	0	Pig	Binding	pEC50	=	6.1	6.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
	CHEMBL262124	96438	None	0	Pig	Binding	pEC50	=	6.1	6.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
	CHEMBL303624	96438	None	0	Pig	Binding	pEC50	=	6.1	6.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
	10509706	96438	None	0	Pig	Binding	pEC50	=	6.1	6.1	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
	CHEMBL262124	96438	None	0	Pig	Binding	pEC50	=	6.1	6.1	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
	CHEMBL303624	96438	None	0	Pig	Binding	pEC50	=	6.1	6.1	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
	10348116	104816	None	0	Pig	Binding	pEC50	=	6.1	6.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@@H]2C1=O	10.1021/jm021077w
	CHEMBL31097	104816	None	0	Pig	Binding	pEC50	=	6.1	6.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@@H]2C1=O	10.1021/jm021077w
	44319180	12076	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL1183728	12076	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL315340	12076	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	118714967	120840	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	CHEMBL3337858	120840	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	CHEMBL3558416	120840	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	46878256	14162	None	0	Human	Binding	pEC50	=	8.1	8.1	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1198561	14162	None	0	Human	Binding	pEC50	=	8.1	8.1	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	CHEMBL607179	14162	None	0	Human	Binding	pEC50	=	8.1	8.1	-	0	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	11115574	11082	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL1177955	11082	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL8532	11082	None	0	Pig	Binding	pEC50	=	8.1	8.1	-	0	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	2230	465	None	60	Human	Binding	pEC50	=	7.1	7.1	-75	10	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
	296	465	None	60	Human	Binding	pEC50	=	7.1	7.1	-75	10	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
	CHEMBL7303	465	None	60	Human	Binding	pEC50	=	7.1	7.1	-75	10	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
	DB04365	465	None	60	Human	Binding	pEC50	=	7.1	7.1	-75	10	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
	11636025	11807	None	0	Pig	Binding	pEC50	=	7.1	7.1	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL1181949	11807	None	0	Pig	Binding	pEC50	=	7.1	7.1	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL201016	11807	None	0	Pig	Binding	pEC50	=	7.1	7.1	-	0	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	170332	160974	None	1	Human	Binding	pEC50	=	6.1	6.1	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Binding	pEC50	=	6.1	6.1	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Binding	pEC50	=	6.1	6.1	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	170332	160974	None	1	Human	Binding	pEC50	=	6.1	6.1	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Binding	pEC50	=	6.1	6.1	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Binding	pEC50	=	6.1	6.1	3	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	10748143	99660	None	0	Pig	Binding	pEC50	=	7.1	7.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	CHEMBL2111531	99660	None	0	Pig	Binding	pEC50	=	7.1	7.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	CHEMBL284393	99660	None	0	Pig	Binding	pEC50	=	7.1	7.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	10748143	99660	None	0	Pig	Binding	pEC50	=	7.1	7.1	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	CHEMBL2111531	99660	None	0	Pig	Binding	pEC50	=	7.1	7.1	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	CHEMBL284393	99660	None	0	Pig	Binding	pEC50	=	7.1	7.1	-	0	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	11504244	106517	None	0	Guinea pig	Binding	pEC50	=	6.1	6.1	-	2	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	60138185	106517	None	0	Guinea pig	Binding	pEC50	=	6.1	6.1	-	2	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121474	106517	None	0	Guinea pig	Binding	pEC50	=	6.1	6.1	-	2	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140249	106517	None	0	Guinea pig	Binding	pEC50	=	6.1	6.1	-	2	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	10767691	107757	None	0	Pig	Binding	pEC50	=	5.1	5.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL171215	107757	None	0	Pig	Binding	pEC50	=	5.1	5.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31915	107757	None	0	Pig	Binding	pEC50	=	5.1	5.1	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	10767691	107757	None	0	Pig	Binding	pEC50	=	5.1	5.1	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL171215	107757	None	0	Pig	Binding	pEC50	=	5.1	5.1	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL31915	107757	None	0	Pig	Binding	pEC50	=	5.1	5.1	-	0	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	10050814	109791	None	0	Pig	Binding	pEC50	=	5.0	5.0	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	399	8	0	2	5.5	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCCc2ccccc2)cc1	10.1021/jm00036a008
	CHEMBL32329	109791	None	0	Pig	Binding	pEC50	=	5.0	5.0	-	0	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	399	8	0	2	5.5	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCCc2ccccc2)cc1	10.1021/jm00036a008
	102070733	120839	None	0	Pig	Binding	pEC50	=	7.0	7.0	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337857	120839	None	0	Pig	Binding	pEC50	=	7.0	7.0	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558415	120839	None	0	Pig	Binding	pEC50	=	7.0	7.0	-	0	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	44340802	62129	None	0	Pig	Binding	pEC50	=	5.0	5.0	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	500	15	0	4	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)CCC1=O	10.1021/jm021077w
	CHEMBL177732	62129	None	0	Pig	Binding	pEC50	=	5.0	5.0	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	500	15	0	4	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)CCC1=O	10.1021/jm021077w
	11331580	202134	None	0	Pig	Binding	pEC50	=	6	6.0	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	726	23	0	6	7.8	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCc1ccccc1)CCCN1C(=O)c2ccccc2C1=O)CCCc1ccccc1	10.1021/jm021077w
	CHEMBL609125	202134	None	0	Pig	Binding	pEC50	=	6	6.0	-	0	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	726	23	0	6	7.8	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCc1ccccc1)CCCN1C(=O)c2ccccc2C1=O)CCCc1ccccc1	10.1021/jm021077w
	367	3822	None	12	Human	Binding	pIC50	=	10.5	10.5	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	5487427	3822	None	12	Human	Binding	pIC50	=	10.5	10.5	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	8592	3822	None	12	Human	Binding	pIC50	=	10.5	10.5	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	CHEMBL1900528	3822	None	12	Human	Binding	pIC50	=	10.5	10.5	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	CHEMBL3305968	3822	None	12	Human	Binding	pIC50	=	10.5	10.5	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	CHEMBL4650755	3822	None	12	Human	Binding	pIC50	=	10.5	10.5	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	DB01409	3822	None	12	Human	Binding	pIC50	=	10.5	10.5	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	367	3822	None	12	Human	Binding	pIC50	=	10.2	10.2	-2	8	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	5487427	3822	None	12	Human	Binding	pIC50	=	10.2	10.2	-2	8	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	8592	3822	None	12	Human	Binding	pIC50	=	10.2	10.2	-2	8	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	CHEMBL1900528	3822	None	12	Human	Binding	pIC50	=	10.2	10.2	-2	8	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	CHEMBL3305968	3822	None	12	Human	Binding	pIC50	=	10.2	10.2	-2	8	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	CHEMBL4650755	3822	None	12	Human	Binding	pIC50	=	10.2	10.2	-2	8	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	DB01409	3822	None	12	Human	Binding	pIC50	=	10.2	10.2	-2	8	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	11434515	261	None	6	Human	Binding	pIC50	=	9.9	9.9	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	11519741	261	None	6	Human	Binding	pIC50	=	9.9	9.9	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	4484	261	None	6	Human	Binding	pIC50	=	9.9	9.9	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	7449	261	None	6	Human	Binding	pIC50	=	9.9	9.9	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	CHEMBL1194325	261	None	6	Human	Binding	pIC50	=	9.9	9.9	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	DB08897	261	None	6	Human	Binding	pIC50	=	9.9	9.9	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	10143956	13909	None	0	Human	Binding	pIC50	=	9.9	9.9	1	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL1196359	13909	None	0	Human	Binding	pIC50	=	9.9	9.9	1	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL556635	13909	None	0	Human	Binding	pIC50	=	9.9	9.9	1	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	11693	1825	None	16	Human	Binding	pIC50	=	9.8	9.8	-2	5	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	3494	1825	None	16	Human	Binding	pIC50	=	9.8	9.8	-2	5	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	4302	1825	None	16	Human	Binding	pIC50	=	9.8	9.8	-2	5	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	7459	1825	None	16	Human	Binding	pIC50	=	9.8	9.8	-2	5	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	9933193	1825	None	16	Human	Binding	pIC50	=	9.8	9.8	-2	5	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	CHEMBL1201335	1825	None	16	Human	Binding	pIC50	=	9.8	9.8	-2	5	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	DB00986	1825	None	16	Human	Binding	pIC50	=	9.8	9.8	-2	5	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	11434515	261	None	6	Human	Binding	pIC50	=	9.8	9.8	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	11519741	261	None	6	Human	Binding	pIC50	=	9.8	9.8	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	4484	261	None	6	Human	Binding	pIC50	=	9.8	9.8	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	7449	261	None	6	Human	Binding	pIC50	=	9.8	9.8	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	CHEMBL1194325	261	None	6	Human	Binding	pIC50	=	9.8	9.8	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	DB08897	261	None	6	Human	Binding	pIC50	=	9.8	9.8	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	44233403	13899	None	0	Human	Binding	pIC50	=	9.8	9.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL1196247	13899	None	0	Human	Binding	pIC50	=	9.8	9.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL556222	13899	None	0	Human	Binding	pIC50	=	9.8	9.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	44233401	13622	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
	CHEMBL1194321	13622	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
	CHEMBL551327	13622	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
	11852298	14024	None	0	Human	Binding	pIC50	=	9.7	9.7	-1	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1197251	14024	None	0	Human	Binding	pIC50	=	9.7	9.7	-1	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL564057	14024	None	0	Human	Binding	pIC50	=	9.7	9.7	-1	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	155566290	176578	None	0	Human	Binding	pIC50	=	9.7	9.7	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176578	None	0	Human	Binding	pIC50	=	9.7	9.7	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176578	None	0	Human	Binding	pIC50	=	9.7	9.7	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	367	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	5487427	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	8592	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	CHEMBL1900528	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	CHEMBL3305968	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	CHEMBL4650755	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	DB01409	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	367	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	5487427	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	8592	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL1900528	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL3305968	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL4650755	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	DB01409	3822	None	12	Human	Binding	pIC50	=	9.7	9.7	-2	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	44232930	196691	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL564747	196691	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	44232931	196379	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL562642	196379	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	44232927	195335	None	8	Human	Binding	pIC50	=	9.6	9.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	349	4	1	6	2.7	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL551729	195335	None	8	Human	Binding	pIC50	=	9.6	9.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	349	4	1	6	2.7	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	44236098	195646	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL556426	195646	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	44233177	13898	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL1196246	13898	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL556221	13898	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	44232685	14027	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL1197273	14027	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL564765	14027	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	20735153	13621	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1194314	13621	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL551063	13621	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
	11489419	13616	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	CHEMBL1194274	13616	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	CHEMBL549784	13616	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	44233173	14018	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL1197216	14018	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL562890	14018	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	44236340	13790	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1195513	13790	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL554725	13790	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	688566	195881	None	24	Human	Binding	pIC50	=	9.4	9.4	-	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
	CHEMBL558910	195881	None	24	Human	Binding	pIC50	=	9.4	9.4	-	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
	49800047	14481	None	1	Human	Binding	pIC50	=	9.4	9.4	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	CHEMBL1201024	14481	None	1	Human	Binding	pIC50	=	9.4	9.4	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	CHEMBL1201268	14481	None	1	Human	Binding	pIC50	=	9.4	9.4	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	44232683	13624	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
	CHEMBL1194336	13624	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
	CHEMBL551731	13624	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
	44236336	14011	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	CHEMBL1197131	14011	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	CHEMBL560327	14011	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	11693	1825	None	16	Human	Binding	pIC50	=	9.3	9.3	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	3494	1825	None	16	Human	Binding	pIC50	=	9.3	9.3	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	4302	1825	None	16	Human	Binding	pIC50	=	9.3	9.3	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	7459	1825	None	16	Human	Binding	pIC50	=	9.3	9.3	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	9933193	1825	None	16	Human	Binding	pIC50	=	9.3	9.3	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	CHEMBL1201335	1825	None	16	Human	Binding	pIC50	=	9.3	9.3	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	DB00986	1825	None	16	Human	Binding	pIC50	=	9.3	9.3	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	9913341	82156	None	4	Human	Binding	pIC50	=	9.3	9.3	-3	5	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL216927	82156	None	4	Human	Binding	pIC50	=	9.3	9.3	-3	5	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL553058	82156	None	4	Human	Binding	pIC50	=	9.3	9.3	-3	5	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	44236101	14026	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL1197261	14026	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL564515	14026	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	44236099	195553	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL554699	195553	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	10007638	120874	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401648	120874	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559195	120874	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	67548926	120876	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401649	120876	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559201	120876	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	9809330	115997	None	0	Human	Binding	pIC50	=	9.2	9.2	-1	5	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
	CHEMBL335542	115997	None	0	Human	Binding	pIC50	=	9.2	9.2	-1	5	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
	44232681	14013	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1197156	14013	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL561187	14013	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
	10325942	120877	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401650	120877	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559202	120877	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	10143954	13617	None	0	Human	Binding	pIC50	=	9	9.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL1194286	13617	None	0	Human	Binding	pIC50	=	9	9.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL549986	13617	None	0	Human	Binding	pIC50	=	9	9.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	44236332	14015	None	0	Human	Binding	pIC50	=	9.0	9.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL1197183	14015	None	0	Human	Binding	pIC50	=	9.0	9.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL561870	14015	None	0	Human	Binding	pIC50	=	9.0	9.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	10143718	63132	None	0	Human	Binding	pIC50	=	9.0	9.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779131	63132	None	0	Human	Binding	pIC50	=	9.0	9.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789435	63132	None	0	Human	Binding	pIC50	=	9.0	9.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	44235871	196570	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	1	4	2.5	O=C(O[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL563887	196570	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	1	4	2.5	O=C(O[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	50925542	19175	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289653	19175	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	10165877	63128	None	0	Human	Binding	pIC50	=	8.8	8.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779133	63128	None	0	Human	Binding	pIC50	=	8.8	8.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789396	63128	None	0	Human	Binding	pIC50	=	8.8	8.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	11725334	117774	None	0	Human	Binding	pIC50	=	8.8	8.8	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	4	2	5	2.3	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401641	117774	None	0	Human	Binding	pIC50	=	8.8	8.8	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	4	2	5	2.3	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	155566290	176578	None	0	Human	Binding	pIC50	=	8.8	8.8	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176578	None	0	Human	Binding	pIC50	=	8.8	8.8	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176578	None	0	Human	Binding	pIC50	=	8.8	8.8	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	9928017	62337	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779033	62337	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	11569908	13999	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL1197028	13999	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL559106	13999	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
	1201549	596	None	24	Human	Binding	pIC50	=	8	8.0	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	333	596	None	24	Human	Binding	pIC50	=	8	8.0	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	7601	596	None	24	Human	Binding	pIC50	=	8	8.0	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL1201203	596	None	24	Human	Binding	pIC50	=	8	8.0	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL438151	596	None	24	Human	Binding	pIC50	=	8	8.0	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	DB00245	596	None	24	Human	Binding	pIC50	=	8	8.0	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	52942402	19217	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289983	19217	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	44303019	100944	None	0	Rat	Binding	pIC50	=	8	8.0	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL294082	100944	None	0	Rat	Binding	pIC50	=	8	8.0	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	10229167	63123	None	0	Human	Binding	pIC50	=	8.0	8.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779136	63123	None	0	Human	Binding	pIC50	=	8.0	8.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789385	63123	None	0	Human	Binding	pIC50	=	8.0	8.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	14590398	101864	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL300660	101864	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14590401	187976	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL49721	187976	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14054136	60357	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	324	4	1	4	2.7	CN(C)CCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	CHEMBL17460	60357	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	324	4	1	4	2.7	CN(C)CCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	13810575	98580	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/jm00401a016
	CHEMBL276771	98580	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/jm00401a016
	14590398	101864	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL300660	101864	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	14590401	187976	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL49721	187976	None	0	Rat	Binding	pIC50	=	7	7.0	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	44333541	4750	None	0	Rat	Binding	pIC50	=	6	6.0	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	419	4	2	5	3.2	O=C1Nc2cccnc2N(C(=O)CNCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL103785	4750	None	0	Rat	Binding	pIC50	=	6	6.0	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	419	4	2	5	3.2	O=C1Nc2cccnc2N(C(=O)CNCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	60691	101549	None	26	Rat	Binding	pIC50	=	6	6.0	-	0	Inhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellumInhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellum	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
	CHEMBL29835	101549	None	26	Rat	Binding	pIC50	=	6	6.0	-	0	Inhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellumInhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellum	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
	24739387	188155	None	0	Human	Binding	pIC50	=	5	5.0	-	0	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	454	4	0	2	5.2	CC(=O)N1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
	CHEMBL498556	188155	None	0	Human	Binding	pIC50	=	5	5.0	-	0	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	454	4	0	2	5.2	CC(=O)N1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
	CHEMBL4639128	214020	None	17	Human	Binding	pIC50	=	5	5.0	-	0	Cross screening panelCross screening panel	ChEMBL		None	None	None		COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC[C@H]4CCNC4)cc3c2n1[C@H](C)c1ccccc1	10.6019/CHEMBL4630907
	44275628	11992	None	0	Rat	Binding	pIC50	=	5	5.0	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1183229	11992	None	0	Rat	Binding	pIC50	=	5	5.0	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL285803	11992	None	0	Rat	Binding	pIC50	=	5	5.0	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
	10354348	98880	None	0	Human	Binding	pIC50	=	4	4.0	-	0	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	241	2	0	5	2.4	CSc1nsnc1C1=C(C)CCN(C)C1	10.1021/jm9705216
	CHEMBL279105	98880	None	0	Human	Binding	pIC50	=	4	4.0	-	0	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	241	2	0	5	2.4	CSc1nsnc1C1=C(C)CCN(C)C1	10.1021/jm9705216
	67549179	117778	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1016/j.bmcl.2015.02.065
	CHEMBL3401645	117778	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1016/j.bmcl.2015.02.065
	10784004	13385	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1192621	13385	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL543890	13385	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	137630050	161038	None	0	Human	Binding	pIC50	=	5.0	5.0	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pIC50	=	5.0	5.0	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pIC50	=	5.0	5.0	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pIC50	=	5.0	5.0	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	2774	3866	None	95	Human	Binding	pIC50	=	7.0	7.0	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	5593	3866	None	95	Human	Binding	pIC50	=	7.0	7.0	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	7319	3866	None	95	Human	Binding	pIC50	=	7.0	7.0	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	CHEMBL1200604	3866	None	95	Human	Binding	pIC50	=	7.0	7.0	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	DB00809	3866	None	95	Human	Binding	pIC50	=	7.0	7.0	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	DB01199	3866	None	95	Human	Binding	pIC50	=	7.0	7.0	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	1224	1431	None	83	Human	Binding	pIC50	=	6.0	6.0	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	3100	1431	None	83	Human	Binding	pIC50	=	6.0	6.0	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	8980	1431	None	83	Human	Binding	pIC50	=	6.0	6.0	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	916	1431	None	83	Human	Binding	pIC50	=	6.0	6.0	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	CHEMBL657	1431	None	83	Human	Binding	pIC50	=	6.0	6.0	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	DB01075	1431	None	83	Human	Binding	pIC50	=	6.0	6.0	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	100	3803	None	58	Human	Binding	pIC50	=	7.0	7.0	-19	55	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2637	3803	None	58	Human	Binding	pIC50	=	7.0	7.0	-19	55	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	5452	3803	None	58	Human	Binding	pIC50	=	7.0	7.0	-19	55	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	CHEMBL479	3803	None	58	Human	Binding	pIC50	=	7.0	7.0	-19	55	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	DB00679	3803	None	58	Human	Binding	pIC50	=	7.0	7.0	-19	55	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	124087	1388	None	114	Human	Binding	pIC50	=	7.0	7.0	-6	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	7157	1388	None	114	Human	Binding	pIC50	=	7.0	7.0	-6	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	814	1388	None	114	Human	Binding	pIC50	=	7.0	7.0	-6	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	CHEMBL1172	1388	None	114	Human	Binding	pIC50	=	7.0	7.0	-6	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	DB00967	1388	None	114	Human	Binding	pIC50	=	7.0	7.0	-6	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	135	2530	None	43	Human	Binding	pIC50	=	6.0	6.0	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	1796	2530	None	43	Human	Binding	pIC50	=	6.0	6.0	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	4184	2530	None	43	Human	Binding	pIC50	=	6.0	6.0	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	CHEMBL6437	2530	None	43	Human	Binding	pIC50	=	6.0	6.0	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	DB06148	2530	None	43	Human	Binding	pIC50	=	6.0	6.0	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	10782321	12122	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
	CHEMBL1184098	12122	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
	CHEMBL332405	12122	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
	10080742	206364	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	166	3	0	3	0.9	C=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL87485	206364	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	166	3	0	3	0.9	C=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	2284	3180	None	33	Human	Binding	pIC50	=	6.0	6.0	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	4926	3180	None	33	Human	Binding	pIC50	=	6.0	6.0	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	7281	3180	None	33	Human	Binding	pIC50	=	6.0	6.0	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	CHEMBL564	3180	None	33	Human	Binding	pIC50	=	6.0	6.0	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	DB00420	3180	None	33	Human	Binding	pIC50	=	6.0	6.0	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	10594386	11416	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1180249	11416	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL118553	11416	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	2230	465	None	60	Rat	Binding	pIC50	=	5.0	5.0	-107	10	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	296	465	None	60	Rat	Binding	pIC50	=	5.0	5.0	-107	10	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	CHEMBL7303	465	None	60	Rat	Binding	pIC50	=	5.0	5.0	-107	10	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	DB04365	465	None	60	Rat	Binding	pIC50	=	5.0	5.0	-107	10	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	9946632	62347	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	354	4	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccc(F)cc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779043	62347	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	354	4	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccc(F)cc1	10.1016/j.bmcl.2011.03.096
	44302901	101054	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	320	1	1	3	3.9	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)cc34)OC21	10.1016/s0960-894x(98)00351-5
	CHEMBL294726	101054	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	320	1	1	3	3.9	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)cc34)OC21	10.1016/s0960-894x(98)00351-5
	6726	1279	None	51	Human	Binding	pIC50	=	5.9	5.9	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	7151	1279	None	51	Human	Binding	pIC50	=	5.9	5.9	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	749	1279	None	51	Human	Binding	pIC50	=	5.9	5.9	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL648	1279	None	51	Human	Binding	pIC50	=	5.9	5.9	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB01176	1279	None	51	Human	Binding	pIC50	=	5.9	5.9	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	2683	102886	None	25	Human	Binding	pIC50	=	6.9	6.9	-5	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL305906	102886	None	25	Human	Binding	pIC50	=	6.9	6.9	-5	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL334255	102886	None	25	Human	Binding	pIC50	=	6.9	6.9	-5	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	10547222	114784	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.7	CCCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL333940	114784	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.7	CCCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	44236338	13908	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1196358	13908	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL556634	13908	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	52948443	19191	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	419	4	0	5	3.9	CCc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289758	19191	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	419	4	0	5	3.9	CCc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	2551	793	None	23	Human	Binding	pIC50	=	7.9	7.9	-6	11	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	298	793	None	23	Human	Binding	pIC50	=	7.9	7.9	-6	11	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	488	793	None	23	Human	Binding	pIC50	=	7.9	7.9	-6	11	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	CHEMBL965	793	None	23	Human	Binding	pIC50	=	7.9	7.9	-6	11	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	DB00411	793	None	23	Human	Binding	pIC50	=	7.9	7.9	-6	11	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	3652	4095	None	79	Human	Binding	pIC50	=	7.9	7.9	-18	18	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	57	4095	None	79	Human	Binding	pIC50	=	7.9	7.9	-18	18	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	60809	4095	None	79	Human	Binding	pIC50	=	7.9	7.9	-18	18	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	CHEMBL21536	4095	None	79	Human	Binding	pIC50	=	7.9	7.9	-18	18	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	DB15357	4095	None	79	Human	Binding	pIC50	=	7.9	7.9	-18	18	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	14590397	187695	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL49525	187695	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14054141	162482	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
	CHEMBL416723	162482	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
	9815331	203105	None	1	Rat	Binding	pIC50	=	6.9	6.9	1	8	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203105	None	1	Rat	Binding	pIC50	=	6.9	6.9	1	8	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	14590397	187695	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL49525	187695	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	9815331	203105	None	1	Human	Binding	pIC50	=	6.9	6.9	-1	8	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203105	None	1	Human	Binding	pIC50	=	6.9	6.9	-1	8	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	11793999	12113	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184074	12113	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL331516	12113	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	18456768	63133	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779134	63133	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789445	63133	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	2200	3129	None	46	Rat	Binding	pIC50	=	5.9	5.9	-31	13	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
	328	3129	None	46	Rat	Binding	pIC50	=	5.9	5.9	-31	13	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
	4848	3129	None	46	Rat	Binding	pIC50	=	5.9	5.9	-31	13	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
	CHEMBL9967	3129	None	46	Rat	Binding	pIC50	=	5.9	5.9	-31	13	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
	DB00670	3129	None	46	Rat	Binding	pIC50	=	5.9	5.9	-31	13	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
	13271739	98524	None	0	Rat	Binding	pIC50	=	5.9	5.9	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	1	2	4	2.6	CN1CCC(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL276282	98524	None	0	Rat	Binding	pIC50	=	5.9	5.9	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	1	2	4	2.6	CN1CCC(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	14054138	98824	None	0	Rat	Binding	pIC50	=	4.9	4.9	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	365	3	1	5	2.0	CN1CCN(CCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL278701	98824	None	0	Rat	Binding	pIC50	=	4.9	4.9	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	365	3	1	5	2.0	CN1CCN(CCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	53853235	78679	None	0	Rat	Binding	pIC50	=	4.9	4.9	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	401	2	0	5	3.6	O=C1c2ccccc2-n2c(nc3cccnc32)CN1C[C@@H]1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
	CHEMBL2112432	78679	None	0	Rat	Binding	pIC50	=	4.9	4.9	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	401	2	0	5	3.6	O=C1c2ccccc2-n2c(nc3cccnc32)CN1C[C@@H]1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
	10829928	12400	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
	CHEMBL1185758	12400	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
	CHEMBL431688	12400	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
	15730	71116	None	80	Human	Binding	pIC50	=	4.9	4.9	-2	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
	CHEMBL195437	71116	None	80	Human	Binding	pIC50	=	4.9	4.9	-2	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
	10827157	11435	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	CHEMBL1180317	11435	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	CHEMBL121552	11435	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	52947552	19105	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	404	4	1	5	2.9	O=C(c1ccc(CO)o1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289201	19105	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	404	4	1	5	2.9	O=C(c1ccc(CO)o1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	52943921	19122	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	386	3	0	5	2.6	O=C(c1ncccn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289315	19122	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	386	3	0	5	2.6	O=C(c1ncccn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	52942610	19325	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	384	3	0	3	3.8	O=C(c1ccccc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290635	19325	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	384	3	0	3	3.8	O=C(c1ccccc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	46891076	6706	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	344	4	2	2	3.8	O=C(NCC1=CCNCC1)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	CHEMBL1083618	6706	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	344	4	2	2	3.8	O=C(NCC1=CCNCC1)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	441383	20331	None	57	Human	Binding	pIC50	=	4.9	4.9	-7	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	CHEMBL1306	20331	None	57	Human	Binding	pIC50	=	4.9	4.9	-7	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	9944783	62341	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	316	6	0	3	3.9	CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779037	62341	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	316	6	0	3	3.9	CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	2551	793	None	23	Rat	Binding	pIC50	=	6.9	6.9	-3	11	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	793	None	23	Rat	Binding	pIC50	=	6.9	6.9	-3	11	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	793	None	23	Rat	Binding	pIC50	=	6.9	6.9	-3	11	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	793	None	23	Rat	Binding	pIC50	=	6.9	6.9	-3	11	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	793	None	23	Rat	Binding	pIC50	=	6.9	6.9	-3	11	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	2551	793	None	23	Human	Binding	pIC50	=	6.9	6.9	-6	11	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	793	None	23	Human	Binding	pIC50	=	6.9	6.9	-6	11	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	793	None	23	Human	Binding	pIC50	=	6.9	6.9	-6	11	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	793	None	23	Human	Binding	pIC50	=	6.9	6.9	-6	11	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	793	None	23	Human	Binding	pIC50	=	6.9	6.9	-6	11	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	10567372	12129	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1160977	12129	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1184119	12129	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL333065	12129	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	44302788	200620	None	0	Human	Binding	pIC50	=	4.9	4.9	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	2	1	5	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL59939	200620	None	0	Human	Binding	pIC50	=	4.9	4.9	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	2	1	5	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	122203596	155804	None	0	Human	Binding	pIC50	=	5.9	5.9	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pIC50	=	5.9	5.9	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pIC50	=	5.9	5.9	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	10760249	11421	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
	CHEMBL1180285	11421	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
	CHEMBL120119	11421	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
	10760249	11421	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	CHEMBL1180285	11421	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	CHEMBL120119	11421	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	67547950	120875	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	CHEMBL3401655	120875	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	CHEMBL3559199	120875	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	54586723	62342	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	3	0	3	3.1	CC(C)N(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779038	62342	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	3	0	3	3.1	CC(C)N(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	10686494	100536	None	0	Rat	Binding	pIC50	=	7.9	7.9	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	CHEMBL291351	100536	None	0	Rat	Binding	pIC50	=	7.9	7.9	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	10393952	63127	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779140	63127	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789389	63127	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	9798900	63134	None	1	Human	Binding	pIC50	=	7.8	7.8	-	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
	CHEMBL1779047	63134	None	1	Human	Binding	pIC50	=	7.8	7.8	-	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
	CHEMBL1789446	63134	None	1	Human	Binding	pIC50	=	7.8	7.8	-	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
	107867	2972	None	55	Rat	Binding	pIC50	=	6.9	6.9	-14	11	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	309	2972	None	55	Rat	Binding	pIC50	=	6.9	6.9	-14	11	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	CHEMBL17045	2972	None	55	Rat	Binding	pIC50	=	6.9	6.9	-14	11	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	13578548	101360	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL296988	101360	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	107867	2972	None	55	Rat	Binding	pIC50	=	6.9	6.9	-14	11	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	309	2972	None	55	Rat	Binding	pIC50	=	6.9	6.9	-14	11	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	CHEMBL17045	2972	None	55	Rat	Binding	pIC50	=	6.9	6.9	-14	11	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	13578548	101360	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL296988	101360	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	67548544	120880	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	CHEMBL3401656	120880	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	CHEMBL3559205	120880	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	3088389	23112	None	3	Mouse	Binding	pIC50	=	5.9	5.9	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	368	11	0	6	4.2	CN(C)Cc1ccc(CSCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL13308	23112	None	3	Mouse	Binding	pIC50	=	5.9	5.9	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	368	11	0	6	4.2	CN(C)Cc1ccc(CSCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	2551	793	None	23	Human	Binding	pIC50	=	5.9	5.9	-6	11	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
	298	793	None	23	Human	Binding	pIC50	=	5.9	5.9	-6	11	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
	488	793	None	23	Human	Binding	pIC50	=	5.9	5.9	-6	11	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
	CHEMBL965	793	None	23	Human	Binding	pIC50	=	5.9	5.9	-6	11	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
	DB00411	793	None	23	Human	Binding	pIC50	=	5.9	5.9	-6	11	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
	2247	505	None	81	Human	Binding	pIC50	=	5.9	5.9	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	505	None	81	Human	Binding	pIC50	=	5.9	5.9	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	505	None	81	Human	Binding	pIC50	=	5.9	5.9	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	505	None	81	Human	Binding	pIC50	=	5.9	5.9	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	505	None	81	Human	Binding	pIC50	=	5.9	5.9	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	44303294	201154	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60331	201154	None	0	Rat	Binding	pIC50	=	6.9	6.9	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	4735	195113	None	96	Human	Binding	pIC50	=	5.9	5.9	-9	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	CHEMBL361506	195113	None	96	Human	Binding	pIC50	=	5.9	5.9	-9	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	CHEMBL55	195113	None	96	Human	Binding	pIC50	=	5.9	5.9	-9	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	11057	176147	None	23	Human	Binding	pIC50	=	5.8	5.8	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	3468	176147	None	23	Human	Binding	pIC50	=	5.8	5.8	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL459265	176147	None	23	Human	Binding	pIC50	=	5.8	5.8	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL64894	176147	None	23	Human	Binding	pIC50	=	5.8	5.8	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	2812	4777	None	101	Human	Binding	pIC50	=	4.8	4.8	-33	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	CHEMBL104	4777	None	101	Human	Binding	pIC50	=	4.8	4.8	-33	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	10518821	12125	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184108	12125	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	CHEMBL332645	12125	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	44302793	199727	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	350	2	1	4	3.9	COc1cc2c(cc1OC)C1Oc3ccc4[nH]c(C)cc4c3CN1CC2	10.1016/s0960-894x(98)00351-5
	CHEMBL59347	199727	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	350	2	1	4	3.9	COc1cc2c(cc1OC)C1Oc3ccc4[nH]c(C)cc4c3CN1CC2	10.1016/s0960-894x(98)00351-5
	10664532	12110	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184064	12110	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL330892	12110	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	52945272	19206	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	399	4	0	5	3.8	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289866	19206	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	399	4	0	5	3.8	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	52943721	19287	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	354	3	0	3	4.3	O=C(c1ccsc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290410	19287	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	354	3	0	3	4.3	O=C(c1ccsc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	379653	101681	None	2	Rat	Binding	pIC50	=	6.8	6.8	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL299344	101681	None	2	Rat	Binding	pIC50	=	6.8	6.8	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	13578572	186897	None	0	Rat	Binding	pIC50	=	6.8	6.8	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL48980	186897	None	0	Rat	Binding	pIC50	=	6.8	6.8	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14054140	98938	None	0	Rat	Binding	pIC50	=	6.8	6.8	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	364	2	1	4	3.4	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL279528	98938	None	0	Rat	Binding	pIC50	=	6.8	6.8	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	364	2	1	4	3.4	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	5487543	205644	None	4	Rat	Binding	pIC50	=	6.8	6.8	-	0	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	CHEMBL81878	205644	None	4	Rat	Binding	pIC50	=	6.8	6.8	-	0	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	24750278	89422	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	450	6	1	9	1.7	CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C	10.1021/acs.jmedchem.6b00475
	CHEMBL237067	89422	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	450	6	1	9	1.7	CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C	10.1021/acs.jmedchem.6b00475
	379653	101681	None	2	Rat	Binding	pIC50	=	6.8	6.8	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL299344	101681	None	2	Rat	Binding	pIC50	=	6.8	6.8	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	13578572	186897	None	0	Rat	Binding	pIC50	=	6.8	6.8	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL48980	186897	None	0	Rat	Binding	pIC50	=	6.8	6.8	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	14590400	177460	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL46390	177460	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	3071772	98418	None	3	Mouse	Binding	pIC50	=	5.8	5.8	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	382	12	0	6	4.6	CN(C)Cc1ccc(CSCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL275537	98418	None	3	Mouse	Binding	pIC50	=	5.8	5.8	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	382	12	0	6	4.6	CN(C)Cc1ccc(CSCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	14590400	177460	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL46390	177460	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	10638050	11413	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL116601	11413	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1180202	11413	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	10848032	206091	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1ccsc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL85645	206091	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1ccsc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	44342270	9928	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
	CHEMBL114484	9928	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
	3652	4095	None	79	Rat	Binding	pIC50	=	7.8	7.8	-	18	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	57	4095	None	79	Rat	Binding	pIC50	=	7.8	7.8	-	18	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	60809	4095	None	79	Rat	Binding	pIC50	=	7.8	7.8	-	18	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	CHEMBL21536	4095	None	79	Rat	Binding	pIC50	=	7.8	7.8	-	18	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	DB15357	4095	None	79	Rat	Binding	pIC50	=	7.8	7.8	-	18	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	44303286	201316	None	0	Rat	Binding	pIC50	=	7.8	7.8	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL60419	201316	None	0	Rat	Binding	pIC50	=	7.8	7.8	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	3071780	18788	None	3	Mouse	Binding	pIC50	=	5.8	5.8	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	520	13	0	6	7.5	CN(C)Cc1ccc(CSCc2ccc(-c3ccc(CSCc4ccc(CN(C)C)o4)cc3)cc2)o1	10.1021/jm00084a015
	CHEMBL12781	18788	None	3	Mouse	Binding	pIC50	=	5.8	5.8	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	520	13	0	6	7.5	CN(C)Cc1ccc(CSCc2ccc(-c3ccc(CSCc4ccc(CN(C)C)o4)cc3)cc2)o1	10.1021/jm00084a015
	44275648	11982	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1183077	11982	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL278618	11982	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	13621567	98158	None	7	Rat	Binding	pIC50	=	4.8	4.8	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	CHEMBL27384	98158	None	7	Rat	Binding	pIC50	=	4.8	4.8	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	CHEMBL440085	98158	None	7	Rat	Binding	pIC50	=	4.8	4.8	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	10757736	14502	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL120135	14502	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	10567372	12129	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1160977	12129	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1184119	12129	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL333065	12129	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	10567372	12129	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1160977	12129	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1184119	12129	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL333065	12129	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	44302834	202708	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	454	4	1	5	5.9	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Oc4ccccc4)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL61700	202708	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	454	4	1	5	5.9	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Oc4ccccc4)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	4098	32503	None	30	Human	Binding	pIC50	=	5.8	5.8	-15	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1255739	32503	None	30	Human	Binding	pIC50	=	5.8	5.8	-15	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1411979	32503	None	30	Human	Binding	pIC50	=	5.8	5.8	-15	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	10516408	11439	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1180330	11439	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL122353	11439	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	10240891	206096	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL85678	206096	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	44303424	200485	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	376	3	0	4	4.6	Clc1cc(Cl)cc(C#CCOc2nsnc2C23CC4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL59862	200485	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	376	3	0	4	4.6	Clc1cc(Cl)cc(C#CCOc2nsnc2C23CC4CC2C3C4)c1	10.1021/jm9910019
	9815331	203105	None	1	Rat	Binding	pIC50	=	7.8	7.8	1	8	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203105	None	1	Rat	Binding	pIC50	=	7.8	7.8	1	8	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	9815331	203105	None	1	Human	Binding	pIC50	=	7.8	7.8	-1	8	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203105	None	1	Human	Binding	pIC50	=	7.8	7.8	-1	8	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	324	1923	None	15	Human	Binding	pIC50	=	7.8	7.8	-1	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
	6436265	1923	None	15	Human	Binding	pIC50	=	7.8	7.8	-1	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
	CHEMBL277642	1923	None	15	Human	Binding	pIC50	=	7.8	7.8	-1	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
	10300661	63135	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779135	63135	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789451	63135	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	13578571	101122	None	1	Rat	Binding	pIC50	=	6.8	6.8	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00128a008
	CHEMBL295214	101122	None	1	Rat	Binding	pIC50	=	6.8	6.8	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00128a008
	13578571	101122	None	1	Rat	Binding	pIC50	=	6.8	6.8	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00048a014
	CHEMBL295214	101122	None	1	Rat	Binding	pIC50	=	6.8	6.8	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00048a014
	10610375	11420	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
	CHEMBL1180284	11420	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
	CHEMBL120109	11420	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
	10610375	11420	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
	CHEMBL1180284	11420	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
	CHEMBL120109	11420	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
	11820032	98222	None	0	Rat	Binding	pIC50	=	4.8	4.8	-	0	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL274329	98222	None	0	Rat	Binding	pIC50	=	4.8	4.8	-	0	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	3013846	188237	None	2	Human	Binding	pIC50	=	5.8	5.8	-4	5	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
	CHEMBL499519	188237	None	2	Human	Binding	pIC50	=	5.8	5.8	-4	5	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
	2745	3859	None	42	Human	Binding	pIC50	=	7.7	7.7	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	5572	3859	None	42	Human	Binding	pIC50	=	7.7	7.7	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	66007	3859	None	42	Human	Binding	pIC50	=	7.7	7.7	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	7315	3859	None	42	Human	Binding	pIC50	=	7.7	7.7	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	CHEMBL1490	3859	None	42	Human	Binding	pIC50	=	7.7	7.7	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	DB00376	3859	None	42	Human	Binding	pIC50	=	7.7	7.7	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	306	3454	None	21	Human	Binding	pIC50	=	6.8	6.8	-8	5	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
	3536	3454	None	21	Human	Binding	pIC50	=	6.8	6.8	-8	5	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
	53930639	3454	None	21	Human	Binding	pIC50	=	6.8	6.8	-8	5	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
	9577995	3454	None	21	Human	Binding	pIC50	=	6.8	6.8	-8	5	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
	CHEMBL134641	3454	None	21	Human	Binding	pIC50	=	6.8	6.8	-8	5	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
	2230	465	None	60	Human	Binding	pIC50	=	5.8	5.8	-75	10	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
	296	465	None	60	Human	Binding	pIC50	=	5.8	5.8	-75	10	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
	CHEMBL7303	465	None	60	Human	Binding	pIC50	=	5.8	5.8	-75	10	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
	DB04365	465	None	60	Human	Binding	pIC50	=	5.8	5.8	-75	10	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
	44275626	11163	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1178434	11163	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL28033	11163	None	0	Rat	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	163388532	190356	None	2	Human	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of muscarinic M2 receptor (unknown origin)Inhibition of muscarinic M2 receptor (unknown origin)	ChEMBL	681	8	2	9	6.2	Cc1c(C#Cc2ccc(CN3CCC(CO)CC3)cc2)cc(C(F)F)c2cn(C(C(=O)Nc3nccs3)c3ncn4c3CCC43CC3)nc12	10.1021/acs.jmedchem.2c00893
	CHEMBL5177023	190356	None	2	Human	Binding	pIC50	=	5.8	5.8	-	0	Inhibition of muscarinic M2 receptor (unknown origin)Inhibition of muscarinic M2 receptor (unknown origin)	ChEMBL	681	8	2	9	6.2	Cc1c(C#Cc2ccc(CN3CCC(CO)CC3)cc2)cc(C(F)F)c2cn(C(C(=O)Nc3nccs3)c3ncn4c3CCC43CC3)nc12	10.1021/acs.jmedchem.2c00893
	CHEMBL4800073	214052	None	5	Human	Binding	pIC50	=	5.8	5.8	-	0	Selectivity interaction (PSP Principial panel 20118+ (panel of GPCRs, transporter, and ion channels)) EUB0000283b CHRM2Selectivity interaction (PSP Principial panel 20118+ (panel of GPCRs, transporter, and ion channels)) EUB0000283b CHRM2	ChEMBL		None	None	None		C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4cnccc4c3)ccc2[nH]1	10.6019/CHEMBL5212743
	44356367	118490	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	266	3	0	2	2.2	C[N+](C)(C)CC#CCOC(=O)c1cccc(Cl)c1	10.1021/jm9702903
	CHEMBL341447	118490	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	266	3	0	2	2.2	C[N+](C)(C)CC#CCOC(=O)c1cccc(Cl)c1	10.1021/jm9702903
	122203596	155804	None	0	Human	Binding	pIC50	=	6.7	6.7	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pIC50	=	6.7	6.7	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pIC50	=	6.7	6.7	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	137630050	161038	None	0	Human	Binding	pIC50	=	4.7	4.7	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pIC50	=	4.7	4.7	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pIC50	=	4.7	4.7	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pIC50	=	4.7	4.7	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	10684720	12092	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1183926	12092	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL324712	12092	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	2551	793	None	23	Rat	Binding	pIC50	=	4.7	4.7	-3	11	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
	298	793	None	23	Rat	Binding	pIC50	=	4.7	4.7	-3	11	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
	488	793	None	23	Rat	Binding	pIC50	=	4.7	4.7	-3	11	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
	CHEMBL965	793	None	23	Rat	Binding	pIC50	=	4.7	4.7	-3	11	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
	DB00411	793	None	23	Rat	Binding	pIC50	=	4.7	4.7	-3	11	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
	19816	57583	None	1	Rat	Binding	pIC50	=	4.7	4.7	-	0	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	153	3	0	2	0.9	CC(=O)CCC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	CHEMBL166736	57583	None	1	Rat	Binding	pIC50	=	4.7	4.7	-	0	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	153	3	0	2	0.9	CC(=O)CCC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	52946249	19086	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	390	3	0	4	3.9	O=C(c1cccs1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289082	19086	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	390	3	0	4	3.9	O=C(c1cccs1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	10420458	206266	None	0	Human	Binding	pIC50	=	5.7	5.7	-	1	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL86903	206266	None	0	Human	Binding	pIC50	=	5.7	5.7	-	1	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	71454411	78447	None	0	Rat	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL2111621	78447	None	0	Rat	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	44302741	202653	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL61412	202653	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	4011	82406	None	49	Human	Binding	pIC50	=	5.7	5.7	-35	24	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	CHEMBL21731	82406	None	49	Human	Binding	pIC50	=	5.7	5.7	-35	24	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	10521205	11427	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1180298	11427	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL120599	11427	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	9903030	62346	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	4	0	3	4.2	Cc1ccc(N(Cc2ccccc2)C(=O)O[C@H]2CN3CCC2CC3)cc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779042	62346	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	4	0	3	4.2	Cc1ccc(N(Cc2ccccc2)C(=O)O[C@H]2CN3CCC2CC3)cc1	10.1016/j.bmcl.2011.03.096
	46871844	6810	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	360	4	2	2	4.1	C[C@H]1CNCC[C@@H]1CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	CHEMBL1083925	6810	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	360	4	2	2	4.1	C[C@H]1CNCC[C@@H]1CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	46871665	6593	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	346	4	2	2	3.9	O=C(NCC1CCNCC1)c1ccccc1-c1cc(Cl)ccc1F	10.1016/j.bmcl.2010.04.128
	CHEMBL1083108	6593	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	346	4	2	2	3.9	O=C(NCC1CCNCC1)c1ccccc1-c1cc(Cl)ccc1F	10.1016/j.bmcl.2010.04.128
	1273	1752	None	16	Human	Binding	pIC50	=	5.7	5.7	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	3450	1752	None	16	Human	Binding	pIC50	=	5.7	5.7	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	356	1752	None	16	Human	Binding	pIC50	=	5.7	5.7	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	6172	1752	None	16	Human	Binding	pIC50	=	5.7	5.7	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	67425	1752	None	16	Human	Binding	pIC50	=	5.7	5.7	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	CHEMBL360055	1752	None	16	Human	Binding	pIC50	=	5.7	5.7	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	DB00483	1752	None	16	Human	Binding	pIC50	=	5.7	5.7	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	25897919	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
	657308	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
	657309	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
	CHEMBL1464005	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
	CHEMBL1621597	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
	DB00332	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
	44236334	14010	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL1197117	14010	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL559931	14010	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
	44233175	14017	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL1197209	14017	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL562655	14017	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	25897919	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	657308	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	657309	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	CHEMBL1464005	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	CHEMBL1621597	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	DB00332	55650	None	14	Human	Binding	pIC50	=	8.7	8.7	-1	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	52947320	19246	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	362	3	0	2	4.5	Cc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccccc2)CC3)c1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290184	19246	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	362	3	0	2	4.5	Cc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccccc2)CC3)c1	10.1016/j.bmcl.2010.10.016
	939077	195066	None	2	Human	Binding	pIC50	=	8.6	8.6	-	1	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL549577	195066	None	2	Human	Binding	pIC50	=	8.6	8.6	-	1	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
	44303323	163240	None	0	Rat	Binding	pIC50	=	7.7	7.7	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL418491	163240	None	0	Rat	Binding	pIC50	=	7.7	7.7	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	10785471	113714	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.9	CCCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL332320	113714	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.9	CCCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	14590403	188393	None	0	Rat	Binding	pIC50	=	6.7	6.7	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00128a008
	CHEMBL50176	188393	None	0	Rat	Binding	pIC50	=	6.7	6.7	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00128a008
	13810574	59692	None	0	Rat	Binding	pIC50	=	6.7	6.7	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	310	3	1	4	2.3	CN(C)CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	CHEMBL17228	59692	None	0	Rat	Binding	pIC50	=	6.7	6.7	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	310	3	1	4	2.3	CN(C)CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	14590403	188393	None	0	Rat	Binding	pIC50	=	6.7	6.7	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00048a014
	CHEMBL50176	188393	None	0	Rat	Binding	pIC50	=	6.7	6.7	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00048a014
	302	2975	None	25	Rat	Binding	pIC50	=	5.7	5.7	-4	8	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	4630	2975	None	25	Rat	Binding	pIC50	=	5.7	5.7	-4	8	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL7634	2975	None	25	Rat	Binding	pIC50	=	5.7	5.7	-4	8	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	24739886	187867	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	469	6	1	3	4.2	NC(=O)CN1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
	CHEMBL496376	187867	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	469	6	1	3	4.2	NC(=O)CN1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
	14590396	172540	None	0	Rat	Binding	pIC50	=	5.7	5.7	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL44838	172540	None	0	Rat	Binding	pIC50	=	5.7	5.7	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14590396	172540	None	0	Rat	Binding	pIC50	=	5.7	5.7	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL44838	172540	None	0	Rat	Binding	pIC50	=	5.7	5.7	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	19716	9265	None	6	Rat	Binding	pIC50	=	5.7	5.7	-	1	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	2	0	2	0.6	CC(=O)N(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	CHEMBL11081	9265	None	6	Rat	Binding	pIC50	=	5.7	5.7	-	1	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	2	0	2	0.6	CC(=O)N(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	10356006	205647	None	0	Human	Binding	pIC50	=	4.7	4.7	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL81895	205647	None	0	Human	Binding	pIC50	=	4.7	4.7	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	10515352	106173	None	0	Human	Binding	pIC50	=	4.7	4.7	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL313749	106173	None	0	Human	Binding	pIC50	=	4.7	4.7	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	122203596	155804	None	0	Human	Binding	pIC50	=	5.7	5.7	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pIC50	=	5.7	5.7	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pIC50	=	5.7	5.7	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	10019339	102624	None	0	Rat	Binding	pIC50	=	7.7	7.7	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL304247	102624	None	0	Rat	Binding	pIC50	=	7.7	7.7	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	1935	3732	None	97	Rat	Binding	pIC50	=	5.7	5.7	-	6	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	2551	3732	None	97	Rat	Binding	pIC50	=	5.7	5.7	-	6	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	6687	3732	None	97	Rat	Binding	pIC50	=	5.7	5.7	-	6	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	CHEMBL95	3732	None	97	Rat	Binding	pIC50	=	5.7	5.7	-	6	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	DB00382	3732	None	97	Rat	Binding	pIC50	=	5.7	5.7	-	6	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	1935	3732	None	97	Mouse	Binding	pIC50	=	5.7	5.7	-6	6	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
	2551	3732	None	97	Mouse	Binding	pIC50	=	5.7	5.7	-6	6	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
	6687	3732	None	97	Mouse	Binding	pIC50	=	5.7	5.7	-6	6	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
	CHEMBL95	3732	None	97	Mouse	Binding	pIC50	=	5.7	5.7	-6	6	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
	DB00382	3732	None	97	Mouse	Binding	pIC50	=	5.7	5.7	-6	6	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
	2750	204059	None	76	Human	Binding	pIC50	=	4.7	4.7	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	CHEMBL7002	204059	None	76	Human	Binding	pIC50	=	4.7	4.7	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	5282593	55256	None	26	Human	Binding	pIC50	=	6.7	6.7	-5	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	CHEMBL1319362	55256	None	26	Human	Binding	pIC50	=	6.7	6.7	-5	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	CHEMBL1618018	55256	None	26	Human	Binding	pIC50	=	6.7	6.7	-5	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	10808719	12130	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184120	12130	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL333125	12130	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	10399393	205784	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL83074	205784	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	4212	198677	None	82	Human	Binding	pIC50	=	6.7	6.7	1	4	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	CHEMBL1417019	198677	None	82	Human	Binding	pIC50	=	6.7	6.7	1	4	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	CHEMBL58	198677	None	82	Human	Binding	pIC50	=	6.7	6.7	1	4	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	154734599	2501	None	12	Human	Binding	pIC50	=	7.7	7.7	1	12	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
	327	2501	None	12	Human	Binding	pIC50	=	7.7	7.7	1	12	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
	4108	2501	None	12	Human	Binding	pIC50	=	7.7	7.7	1	12	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
	CHEMBL27673	2501	None	12	Human	Binding	pIC50	=	7.7	7.7	1	12	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
	154734599	2501	None	12	Human	Binding	pIC50	=	7.7	7.7	1	12	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
	327	2501	None	12	Human	Binding	pIC50	=	7.7	7.7	1	12	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
	4108	2501	None	12	Human	Binding	pIC50	=	7.7	7.7	1	12	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
	CHEMBL27673	2501	None	12	Human	Binding	pIC50	=	7.7	7.7	1	12	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
	10546275	15200	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.5	CCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL121059	15200	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.5	CCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	10133281	62344	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	5	0	5	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779040	62344	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	5	0	5	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
	9857572	62340	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	302	5	0	3	3.5	CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779036	62340	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	302	5	0	3	3.5	CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	13578549	101272	None	1	Rat	Binding	pIC50	=	6.7	6.7	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL296317	101272	None	1	Rat	Binding	pIC50	=	6.7	6.7	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	10678449	22651	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	154	2	0	3	0.6	CO/N=C/[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	CHEMBL132698	22651	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	154	2	0	3	0.6	CO/N=C/[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	13578549	101272	None	1	Rat	Binding	pIC50	=	6.7	6.7	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL296317	101272	None	1	Rat	Binding	pIC50	=	6.7	6.7	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	10846833	49803	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	225	0	0	5	1.7	CN1CCC2=C(C1)c1nsnc1SC2	10.1021/jm9705216
	CHEMBL15675	49803	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	225	0	0	5	1.7	CN1CCC2=C(C1)c1nsnc1SC2	10.1021/jm9705216
	3071773	19406	None	3	Mouse	Binding	pIC50	=	5.7	5.7	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	396	13	0	6	4.9	CN(C)Cc1ccc(CSCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL12937	19406	None	3	Mouse	Binding	pIC50	=	5.7	5.7	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	396	13	0	6	4.9	CN(C)Cc1ccc(CSCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	44275683	99280	None	0	Rat	Binding	pIC50	=	4.7	4.7	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL281944	99280	None	0	Rat	Binding	pIC50	=	4.7	4.7	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL541666	99280	None	0	Rat	Binding	pIC50	=	4.7	4.7	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	10593954	13074	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1190178	13074	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL540316	13074	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	10358345	11440	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1180331	11440	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL122354	11440	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	9996901	117775	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	4	1	4	3.2	O=C(N[C@H]1CN2CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401642	117775	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	4	1	4	3.2	O=C(N[C@H]1CN2CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	3236	67607	None	43	Human	Binding	pIC50	=	5.6	5.6	1	2	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
	CHEMBL1902981	67607	None	43	Human	Binding	pIC50	=	5.6	5.6	1	2	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
	10641009	11424	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1180292	11424	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL120472	11424	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	10726038	119430	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.6	CO/N=C(\C#N)C12CCN(CC1)C2	10.1021/jm9702903
	CHEMBL344892	119430	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.6	CO/N=C(\C#N)C12CCN(CC1)C2	10.1021/jm9702903
	44333603	109645	None	0	Rat	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	5	1	3	4.8	Cc1cc(C(=O)c2ccccc2)ccc1NC(=O)CC1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
	CHEMBL322378	109645	None	0	Rat	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	5	1	3	4.8	Cc1cc(C(=O)c2ccccc2)ccc1NC(=O)CC1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
	3072503	4864	None	6	Rat	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	353	9	1	6	3.7	CN(C)Cc1ccc(CSCCNc2ccc(F)cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL104355	4864	None	6	Rat	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	353	9	1	6	3.7	CN(C)Cc1ccc(CSCCNc2ccc(F)cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	3072518	5244	None	4	Rat	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccn3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL106344	5244	None	4	Rat	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccn3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	2398	953	None	62	Human	Binding	pIC50	=	6.6	6.6	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	2801	953	None	62	Human	Binding	pIC50	=	6.6	6.6	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	701	953	None	62	Human	Binding	pIC50	=	6.6	6.6	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	CHEMBL415	953	None	62	Human	Binding	pIC50	=	6.6	6.6	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	DB01242	953	None	62	Human	Binding	pIC50	=	6.6	6.6	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	10663572	13157	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1190784	13157	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL541584	13157	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	44303396	201234	None	0	Rat	Binding	pIC50	=	6.6	6.6	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60374	201234	None	0	Rat	Binding	pIC50	=	6.6	6.6	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	9974222	11919	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1182709	11919	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL262198	11919	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	10778750	163956	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	CHEMBL420781	163956	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	52942628	19085	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccco1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289081	19085	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccco1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	52942401	19216	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289982	19216	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	44275767	97615	None	0	Rat	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL27096	97615	None	0	Rat	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL540136	97615	None	0	Rat	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	52945255	19305	None	1	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	350	3	0	4	3.0	O=C(c1ncccn1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290520	19305	None	1	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	350	3	0	4	3.0	O=C(c1ncccn1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	46891179	6415	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	378	4	2	2	4.2	C[C@H]1CNCC[C@]1(F)CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	CHEMBL1082365	6415	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	378	4	2	2	4.2	C[C@H]1CNCC[C@]1(F)CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	118728611	117777	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401644	117777	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
	10267601	12127	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1184116	12127	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL332980	12127	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	44302775	202794	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OCC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL62247	202794	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OCC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	10573693	11428	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	CHEMBL1180305	11428	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	CHEMBL120963	11428	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	3158	56265	None	27	Human	Binding	pIC50	=	6.6	6.6	-630	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL1628227	56265	None	27	Human	Binding	pIC50	=	6.6	6.6	-630	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	DB01142	56265	None	27	Human	Binding	pIC50	=	6.6	6.6	-630	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	10220392	206003	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL84893	206003	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	4841	67425	None	5	Human	Binding	pIC50	=	7.6	7.6	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	CHEMBL1889399	67425	None	5	Human	Binding	pIC50	=	7.6	7.6	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	CHEMBL1909073	67425	None	5	Human	Binding	pIC50	=	7.6	7.6	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	44303314	100931	None	0	Rat	Binding	pIC50	=	7.6	7.6	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL293982	100931	None	0	Rat	Binding	pIC50	=	7.6	7.6	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	54585743	62348	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	372	4	0	3	4.2	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccc(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779044	62348	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	372	4	0	3	4.2	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccc(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	44275682	11989	None	0	Rat	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1183197	11989	None	0	Rat	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL284208	11989	None	0	Rat	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	191	403	None	98	Human	Binding	pIC50	=	5.6	5.6	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	201	403	None	98	Human	Binding	pIC50	=	5.6	5.6	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2170	403	None	98	Human	Binding	pIC50	=	5.6	5.6	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	CHEMBL1113	403	None	98	Human	Binding	pIC50	=	5.6	5.6	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	DB00543	403	None	98	Human	Binding	pIC50	=	5.6	5.6	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	3823	50219	None	42	Human	Binding	pIC50	=	4.6	4.6	-44	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	76973198	50219	None	42	Human	Binding	pIC50	=	4.6	4.6	-44	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	CHEMBL157101	50219	None	42	Human	Binding	pIC50	=	4.6	4.6	-44	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	44302900	202796	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	3	1	5	4.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OC(C)C)c34)OC21	10.1016/s0960-894x(98)00351-5
	CHEMBL62251	202796	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	3	1	5	4.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OC(C)C)c34)OC21	10.1016/s0960-894x(98)00351-5
	44302813	101928	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	362	2	1	4	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL301041	101928	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	362	2	1	4	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
	137630050	161038	None	0	Human	Binding	pIC50	=	5.6	5.6	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pIC50	=	5.6	5.6	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pIC50	=	5.6	5.6	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pIC50	=	5.6	5.6	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	2028	2977	None	80	Human	Binding	pIC50	=	7.6	7.6	-8	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	359	2977	None	80	Human	Binding	pIC50	=	7.6	7.6	-8	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	4634	2977	None	80	Human	Binding	pIC50	=	7.6	7.6	-8	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	CHEMBL1231	2977	None	80	Human	Binding	pIC50	=	7.6	7.6	-8	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	DB01062	2977	None	80	Human	Binding	pIC50	=	7.6	7.6	-8	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	44303327	163009	None	0	Rat	Binding	pIC50	=	7.6	7.6	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL417560	163009	None	0	Rat	Binding	pIC50	=	7.6	7.6	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	10539130	106728	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	CHEMBL314420	106728	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	10567192	12094	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1183934	12094	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL324936	12094	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	10567372	12129	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1160977	12129	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1184119	12129	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL333065	12129	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	10777692	11425	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1180296	11425	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL120539	11425	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	68617	205525	None	62	Human	Binding	pIC50	=	5.6	5.6	-32	26	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL1709	205525	None	62	Human	Binding	pIC50	=	5.6	5.6	-32	26	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL809	205525	None	62	Human	Binding	pIC50	=	5.6	5.6	-32	26	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	54585742	62335	None	1	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779031	62335	None	1	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	54582845	63129	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779139	63129	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789405	63129	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	10451242	203112	None	0	Rat	Binding	pIC50	=	7.6	7.6	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL64029	203112	None	0	Rat	Binding	pIC50	=	7.6	7.6	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10262466	98342	None	0	Rat	Binding	pIC50	=	5.6	5.6	-	5	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL275104	98342	None	0	Rat	Binding	pIC50	=	5.6	5.6	-	5	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	122203596	155804	None	0	Human	Binding	pIC50	=	6.6	6.6	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pIC50	=	6.6	6.6	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pIC50	=	6.6	6.6	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	10538337	12109	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
	CHEMBL1184062	12109	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
	CHEMBL330885	12109	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
	67547652	117780	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	2	0	3	3.5	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.02.065
	CHEMBL3401647	117780	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	2	0	3	3.5	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.02.065
	154734599	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
	327	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
	4108	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
	CHEMBL27673	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
	11678378	120884	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
	CHEMBL3401654	120884	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
	CHEMBL3559211	120884	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
	54586745	63138	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779138	63138	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789461	63138	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	134688371	14427	None	10	Human	Binding	pIC50	=	6.5	6.5	-	1	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	13765	14427	None	10	Human	Binding	pIC50	=	6.5	6.5	-	1	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	CHEMBL1200623	14427	None	10	Human	Binding	pIC50	=	6.5	6.5	-	1	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	3652	46242	None	70	Human	Binding	pIC50	=	5.5	5.5	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
	CHEMBL1535	46242	None	70	Human	Binding	pIC50	=	5.5	5.5	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
	50925541	19157	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289545	19157	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	50925543	19176	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289654	19176	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	10119939	63126	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1777827	63126	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789388	63126	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	155522355	176407	None	0	Human	Binding	pIC50	=	8.5	8.5	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176407	None	0	Human	Binding	pIC50	=	8.5	8.5	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176407	None	0	Human	Binding	pIC50	=	8.5	8.5	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	9967590	62139	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	336	4	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1777826	62139	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	336	4	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	174174	523	None	49	Human	Binding	pIC50	=	8.4	8.4	-7	14	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	260	523	None	49	Human	Binding	pIC50	=	8.4	8.4	-7	14	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	320	523	None	49	Human	Binding	pIC50	=	8.4	8.4	-7	14	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	CHEMBL517712	523	None	49	Human	Binding	pIC50	=	8.4	8.4	-7	14	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	DB00572	523	None	49	Human	Binding	pIC50	=	8.4	8.4	-7	14	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	2551	793	None	23	Human	Binding	pIC50	=	8.4	8.4	-6	11	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
	298	793	None	23	Human	Binding	pIC50	=	8.4	8.4	-6	11	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
	488	793	None	23	Human	Binding	pIC50	=	8.4	8.4	-6	11	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
	CHEMBL965	793	None	23	Human	Binding	pIC50	=	8.4	8.4	-6	11	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
	DB00411	793	None	23	Human	Binding	pIC50	=	8.4	8.4	-6	11	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
	10208972	63130	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779129	63130	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789429	63130	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	52942458	19245	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	382	3	0	2	4.9	O=C(c1ccccc1)N1CCC2(CCN(Cc3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290183	19245	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	382	3	0	2	4.9	O=C(c1ccccc1)N1CCC2(CCN(Cc3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	10094518	101391	None	0	Rat	Binding	pIC50	=	7.5	7.5	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL297224	101391	None	0	Rat	Binding	pIC50	=	7.5	7.5	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	10096508	177021	None	0	Rat	Binding	pIC50	=	7.5	7.5	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00128a008
	CHEMBL46315	177021	None	0	Rat	Binding	pIC50	=	7.5	7.5	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00128a008
	11725107	100611	None	0	Rat	Binding	pIC50	=	7.5	7.5	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL291872	100611	None	0	Rat	Binding	pIC50	=	7.5	7.5	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10094518	101391	None	0	Rat	Binding	pIC50	=	7.5	7.5	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL297224	101391	None	0	Rat	Binding	pIC50	=	7.5	7.5	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	10096508	177021	None	0	Rat	Binding	pIC50	=	7.5	7.5	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00048a014
	CHEMBL46315	177021	None	0	Rat	Binding	pIC50	=	7.5	7.5	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00048a014
	3072508	107486	None	3	Rat	Binding	pIC50	=	6.5	6.5	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	522	15	2	11	3.6	CN(C)Cc1ccc(CSCCNc2cc(NCCCN3CCOCC3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL318517	107486	None	3	Rat	Binding	pIC50	=	6.5	6.5	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	522	15	2	11	3.6	CN(C)Cc1ccc(CSCCNc2cc(NCCCN3CCOCC3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	14054145	98626	None	0	Rat	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL277078	98626	None	0	Rat	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL5076569	214447	None	0	Human	Binding	pIC50	=	4.5	4.5	-	0	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2cccnc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
	44302727	101916	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccc(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL300987	101916	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccc(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	10176679	133607	None	0	Rat	Binding	pIC50	=	4.5	4.5	-	0	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	209	3	0	4	0.8	CCN1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	CHEMBL37132	133607	None	0	Rat	Binding	pIC50	=	4.5	4.5	-	0	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	209	3	0	4	0.8	CCN1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	10797864	26143	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	1.0	CO/N=C(\C#N)C12CCCN(CC1)C2	10.1021/jm9702903
	CHEMBL135645	26143	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	1.0	CO/N=C(\C#N)C12CCCN(CC1)C2	10.1021/jm9702903
	52947254	19205	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289865	19205	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	52949961	19346	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	424	3	0	4	4.6	O=C(c1ccc2occc2c1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290752	19346	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	424	3	0	4	4.6	O=C(c1ccc2occc2c1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	3072505	108570	None	3	Rat	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	409	11	2	9	3.5	CNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	CHEMBL320291	108570	None	3	Rat	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	409	11	2	9	3.5	CNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	2551	793	None	23	Rat	Binding	pIC50	=	5.5	5.5	-3	11	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	793	None	23	Rat	Binding	pIC50	=	5.5	5.5	-3	11	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	793	None	23	Rat	Binding	pIC50	=	5.5	5.5	-3	11	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	793	None	23	Rat	Binding	pIC50	=	5.5	5.5	-3	11	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	793	None	23	Rat	Binding	pIC50	=	5.5	5.5	-3	11	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	2551	793	None	23	Human	Binding	pIC50	=	5.5	5.5	-6	11	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	793	None	23	Human	Binding	pIC50	=	5.5	5.5	-6	11	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	793	None	23	Human	Binding	pIC50	=	5.5	5.5	-6	11	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	793	None	23	Human	Binding	pIC50	=	5.5	5.5	-6	11	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	793	None	23	Human	Binding	pIC50	=	5.5	5.5	-6	11	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	2274	3171	None	58	Human	Binding	pIC50	=	5.5	5.5	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	4917	3171	None	58	Human	Binding	pIC50	=	5.5	5.5	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	7279	3171	None	58	Human	Binding	pIC50	=	5.5	5.5	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	CHEMBL728	3171	None	58	Human	Binding	pIC50	=	5.5	5.5	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	DB00433	3171	None	58	Human	Binding	pIC50	=	5.5	5.5	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	3652	4095	None	79	Human	Binding	pIC50	=	6.5	6.5	-18	18	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	57	4095	None	79	Human	Binding	pIC50	=	6.5	6.5	-18	18	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	60809	4095	None	79	Human	Binding	pIC50	=	6.5	6.5	-18	18	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	CHEMBL21536	4095	None	79	Human	Binding	pIC50	=	6.5	6.5	-18	18	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	DB15357	4095	None	79	Human	Binding	pIC50	=	6.5	6.5	-18	18	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	24882193	188647	None	0	Human	Binding	pIC50	=	5.5	5.5	-	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
	CHEMBL503468	188647	None	0	Human	Binding	pIC50	=	5.5	5.5	-	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
	3198	205511	None	76	Human	Binding	pIC50	=	5.5	5.5	-16	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205511	None	76	Human	Binding	pIC50	=	5.5	5.5	-16	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205511	None	76	Human	Binding	pIC50	=	5.5	5.5	-16	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	54586743	63139	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
	CHEMBL1779130	63139	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
	CHEMBL1789462	63139	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
	13578551	101282	None	0	Rat	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL296405	101282	None	0	Rat	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	13578551	101282	None	0	Rat	Binding	pIC50	=	6.5	6.5	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL296405	101282	None	0	Rat	Binding	pIC50	=	6.5	6.5	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	9882189	167432	None	33	Human	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity to muscarinic 2 receptor (unknown origin)Binding affinity to muscarinic 2 receptor (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1016/j.bmc.2022.117032
	CHEMBL4297224	167432	None	33	Human	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity to muscarinic 2 receptor (unknown origin)Binding affinity to muscarinic 2 receptor (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1016/j.bmc.2022.117032
	9882189	167432	None	33	Human	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01192
	CHEMBL4297224	167432	None	33	Human	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01192
	3072510	5363	None	3	Rat	Binding	pIC50	=	5.5	5.5	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	485	13	2	9	5.1	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL106936	5363	None	3	Rat	Binding	pIC50	=	5.5	5.5	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	485	13	2	9	5.1	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	10761219	11429	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1180309	11429	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL121298	11429	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	2337	3254	None	77	Human	Binding	pIC50	=	5.5	5.5	-31	63	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	50	3254	None	77	Human	Binding	pIC50	=	5.5	5.5	-31	63	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	5002	3254	None	77	Human	Binding	pIC50	=	5.5	5.5	-31	63	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	CHEMBL716	3254	None	77	Human	Binding	pIC50	=	5.5	5.5	-31	63	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	DB01224	3254	None	77	Human	Binding	pIC50	=	5.5	5.5	-31	63	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	2745	3859	None	42	Human	Binding	pIC50	=	7.5	7.5	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	5572	3859	None	42	Human	Binding	pIC50	=	7.5	7.5	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	66007	3859	None	42	Human	Binding	pIC50	=	7.5	7.5	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	7315	3859	None	42	Human	Binding	pIC50	=	7.5	7.5	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	CHEMBL1490	3859	None	42	Human	Binding	pIC50	=	7.5	7.5	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	DB00376	3859	None	42	Human	Binding	pIC50	=	7.5	7.5	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	2551	793	None	23	Rat	Binding	pIC50	=	7.5	7.5	-3	11	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	298	793	None	23	Rat	Binding	pIC50	=	7.5	7.5	-3	11	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	488	793	None	23	Rat	Binding	pIC50	=	7.5	7.5	-3	11	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	CHEMBL965	793	None	23	Rat	Binding	pIC50	=	7.5	7.5	-3	11	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	DB00411	793	None	23	Rat	Binding	pIC50	=	7.5	7.5	-3	11	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	154734599	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
	327	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
	4108	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
	CHEMBL27673	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
	154734599	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
	327	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
	4108	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
	CHEMBL27673	2501	None	12	Human	Binding	pIC50	=	7.5	7.5	1	12	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
	24996645	70424	None	0	Human	Binding	pIC50	=	6.5	6.5	-	2	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	416	5	0	6	4.0	Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(C3CCC3)CC2)cc1	10.1016/j.bmcl.2011.11.118
	CHEMBL1945848	70424	None	0	Human	Binding	pIC50	=	6.5	6.5	-	2	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	416	5	0	6	4.0	Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(C3CCC3)CC2)cc1	10.1016/j.bmcl.2011.11.118
	44275767	97615	None	0	Rat	Binding	pIC50	=	4.5	4.5	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL27096	97615	None	0	Rat	Binding	pIC50	=	4.5	4.5	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL540136	97615	None	0	Rat	Binding	pIC50	=	4.5	4.5	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	290	2471	None	6	Rat	Binding	pIC50	=	4.5	4.5	-12	7	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
	4022	2471	None	6	Rat	Binding	pIC50	=	4.5	4.5	-12	7	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
	5926	2471	None	6	Rat	Binding	pIC50	=	4.5	4.5	-12	7	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
	CHEMBL40554	2471	None	6	Rat	Binding	pIC50	=	4.5	4.5	-12	7	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
	CHEMBL74300	2471	None	6	Rat	Binding	pIC50	=	4.5	4.5	-12	7	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
	15685990	58081	None	0	Rat	Binding	pIC50	=	4.5	4.5	-	0	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	3	1	3	1.0	CC(/C=N/O)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	CHEMBL167335	58081	None	0	Rat	Binding	pIC50	=	4.5	4.5	-	0	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	3	1	3	1.0	CC(/C=N/O)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	11498	3017	None	41	Human	Binding	pIC50	=	5.5	5.5	-67	6	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
	4995951	3017	None	41	Human	Binding	pIC50	=	5.5	5.5	-67	6	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
	CHEMBL59898	3017	None	41	Human	Binding	pIC50	=	5.5	5.5	-67	6	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
	1971	2864	None	38	Human	Binding	pIC50	=	6.5	6.5	-9	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	2404	2864	None	38	Human	Binding	pIC50	=	6.5	6.5	-9	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	4543	2864	None	38	Human	Binding	pIC50	=	6.5	6.5	-9	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	CHEMBL445	2864	None	38	Human	Binding	pIC50	=	6.5	6.5	-9	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	DB00540	2864	None	38	Human	Binding	pIC50	=	6.5	6.5	-9	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	11695697	117779	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	1	3	3.1	O=C(N[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
	CHEMBL3401646	117779	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	1	3	3.1	O=C(N[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
	54583839	62339	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	4	0	3	3.1	CCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779035	62339	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	4	0	3	3.1	CCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	277	1300	None	62	Human	Binding	pIC50	=	7.5	7.5	-12	50	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2913	1300	None	62	Human	Binding	pIC50	=	7.5	7.5	-12	50	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	765	1300	None	62	Human	Binding	pIC50	=	7.5	7.5	-12	50	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	CHEMBL516	1300	None	62	Human	Binding	pIC50	=	7.5	7.5	-12	50	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	DB00434	1300	None	62	Human	Binding	pIC50	=	7.5	7.5	-12	50	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2286	3181	None	51	Human	Binding	pIC50	=	7.5	7.5	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	4927	3181	None	51	Human	Binding	pIC50	=	7.5	7.5	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	7282	3181	None	51	Human	Binding	pIC50	=	7.5	7.5	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	CHEMBL643	3181	None	51	Human	Binding	pIC50	=	7.5	7.5	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	DB01069	3181	None	51	Human	Binding	pIC50	=	7.5	7.5	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	118728610	117773	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	336	4	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401640	117773	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	336	4	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2015.02.065
	3067217	61296	None	3	Rat	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	356	2	1	5	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cscc32)CC1	10.1021/jm00401a016
	CHEMBL17671	61296	None	3	Rat	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	356	2	1	5	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cscc32)CC1	10.1021/jm00401a016
	3072506	5322	None	3	Rat	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	437	13	2	9	4.3	CCCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	CHEMBL106782	5322	None	3	Rat	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	437	13	2	9	4.3	CCCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	3072512	5361	None	3	Rat	Binding	pIC50	=	5.5	5.5	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	450	12	2	10	4.3	CC(C)=NNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	CHEMBL106932	5361	None	3	Rat	Binding	pIC50	=	5.5	5.5	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	450	12	2	10	4.3	CC(C)=NNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	10639739	11647	None	2	Rat	Binding	pIC50	=	5.5	5.5	-	0	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
	CHEMBL1181055	11647	None	2	Rat	Binding	pIC50	=	5.5	5.5	-	0	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
	CHEMBL154087	11647	None	2	Rat	Binding	pIC50	=	5.5	5.5	-	0	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
	6918276	15609	None	7	Human	Binding	pIC50	=	5.5	5.5	-131	8	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	CHEMBL1221512	15609	None	7	Human	Binding	pIC50	=	5.5	5.5	-131	8	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	10759393	84383	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL2112589	84383	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL2219563	84383	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	25014630	83537	None	1	Human	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
	CHEMBL2203713	83537	None	1	Human	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
	44275648	11982	None	0	Rat	Binding	pIC50	=	4.4	4.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1183077	11982	None	0	Rat	Binding	pIC50	=	4.4	4.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL278618	11982	None	0	Rat	Binding	pIC50	=	4.4	4.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	1548953	207677	None	27	Human	Binding	pIC50	=	5.4	5.4	-6	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	CHEMBL954	207677	None	27	Human	Binding	pIC50	=	5.4	5.4	-6	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	154734599	2501	None	12	Human	Binding	pIC50	=	7.4	7.4	1	12	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	327	2501	None	12	Human	Binding	pIC50	=	7.4	7.4	1	12	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	4108	2501	None	12	Human	Binding	pIC50	=	7.4	7.4	1	12	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	CHEMBL27673	2501	None	12	Human	Binding	pIC50	=	7.4	7.4	1	12	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	3072515	5192	None	5	Rat	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	496	12	2	10	5.1	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3C#N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL106082	5192	None	5	Rat	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	496	12	2	10	5.1	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3C#N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	202718	87322	None	22	Rat	Binding	pIC50	=	6.4	6.4	-	0	Antagonist activity at rat muscarinic M2 receptor isolated from brainAntagonist activity at rat muscarinic M2 receptor isolated from brain	ChEMBL	277	4	0	1	4.6	C(CN1CCCCC1)=C(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2012.12.054
	CHEMBL2332280	87322	None	22	Rat	Binding	pIC50	=	6.4	6.4	-	0	Antagonist activity at rat muscarinic M2 receptor isolated from brainAntagonist activity at rat muscarinic M2 receptor isolated from brain	ChEMBL	277	4	0	1	4.6	C(CN1CCCCC1)=C(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2012.12.054
	4601	206745	None	35	Human	Binding	pIC50	=	6.4	6.4	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL1201023	206745	None	35	Human	Binding	pIC50	=	6.4	6.4	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL900	206745	None	35	Human	Binding	pIC50	=	6.4	6.4	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	DB01173	206745	None	35	Human	Binding	pIC50	=	6.4	6.4	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	3072507	5247	None	2	Rat	Binding	pIC50	=	6.4	6.4	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	466	14	2	10	3.5	CN(C)CCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	CHEMBL106348	5247	None	2	Rat	Binding	pIC50	=	6.4	6.4	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	466	14	2	10	3.5	CN(C)CCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	1726	2495	None	13	Rat	Binding	pIC50	=	6.4	6.4	-3	5	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2495	None	13	Rat	Binding	pIC50	=	6.4	6.4	-3	5	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2495	None	13	Rat	Binding	pIC50	=	6.4	6.4	-3	5	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2495	None	13	Rat	Binding	pIC50	=	6.4	6.4	-3	5	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2495	None	13	Rat	Binding	pIC50	=	6.4	6.4	-3	5	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1726	2495	None	13	Human	Binding	pIC50	=	6.4	6.4	-2	5	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2495	None	13	Human	Binding	pIC50	=	6.4	6.4	-2	5	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2495	None	13	Human	Binding	pIC50	=	6.4	6.4	-2	5	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2495	None	13	Human	Binding	pIC50	=	6.4	6.4	-2	5	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2495	None	13	Human	Binding	pIC50	=	6.4	6.4	-2	5	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	13621567	98158	None	7	Rat	Binding	pIC50	=	4.4	4.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	CHEMBL27384	98158	None	7	Rat	Binding	pIC50	=	4.4	4.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	CHEMBL440085	98158	None	7	Rat	Binding	pIC50	=	4.4	4.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	10595006	11443	None	0	Human	Binding	pIC50	=	4.4	4.4	-6	5	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	CHEMBL1180343	11443	None	0	Human	Binding	pIC50	=	4.4	4.4	-6	5	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	CHEMBL123099	11443	None	0	Human	Binding	pIC50	=	4.4	4.4	-6	5	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	10595006	11443	None	0	Human	Binding	pIC50	=	4.4	4.4	-6	5	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	CHEMBL1180343	11443	None	0	Human	Binding	pIC50	=	4.4	4.4	-6	5	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	CHEMBL123099	11443	None	0	Human	Binding	pIC50	=	4.4	4.4	-6	5	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	10777343	206167	None	0	Human	Binding	pIC50	=	4.4	4.4	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	254	2	0	3	2.1	Cc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	CHEMBL86288	206167	None	0	Human	Binding	pIC50	=	4.4	4.4	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	254	2	0	3	2.1	Cc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	52946359	19121	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	3	0	6	2.7	O=C(c1cnsn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289314	19121	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	3	0	6	2.7	O=C(c1cnsn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	44275683	99280	None	0	Rat	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL281944	99280	None	0	Rat	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL541666	99280	None	0	Rat	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	9308	17752	None	21	Rat	Binding	pIC50	=	5.4	5.4	-2	7	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17752	None	21	Rat	Binding	pIC50	=	5.4	5.4	-2	7	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17752	None	21	Rat	Binding	pIC50	=	5.4	5.4	-2	7	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17752	None	21	Rat	Binding	pIC50	=	5.4	5.4	-2	7	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	9308	17752	None	21	Human	Binding	pIC50	=	5.4	5.4	2	7	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17752	None	21	Human	Binding	pIC50	=	5.4	5.4	2	7	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17752	None	21	Human	Binding	pIC50	=	5.4	5.4	2	7	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17752	None	21	Human	Binding	pIC50	=	5.4	5.4	2	7	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	10611310	12121	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1184096	12121	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL332335	12121	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	23724781	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	316	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	317	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	71183	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL1354199	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL3140030	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL376897	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	DB00462	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	46890977	6730	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	Cc1ccc(-c2ccccc2C(=O)NCC2CCNCC2)cc1Cl	10.1016/j.bmcl.2010.04.128
	CHEMBL1083723	6730	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	Cc1ccc(-c2ccccc2C(=O)NCC2CCNCC2)cc1Cl	10.1016/j.bmcl.2010.04.128
	46871666	7067	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	CC1CNCCC1CNC(=O)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
	CHEMBL1084993	7067	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	CC1CNCCC1CNC(=O)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
	10208897	63125	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779049	63125	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789387	63125	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	10246307	117776	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	4	2	4	2.3	O=C(N[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401643	117776	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	4	2	4	2.3	O=C(N[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1016/j.bmcl.2015.02.065
	23724781	2833	None	19	Human	Binding	pIC50	=	8.4	8.4	-6	9	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	316	2833	None	19	Human	Binding	pIC50	=	8.4	8.4	-6	9	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	317	2833	None	19	Human	Binding	pIC50	=	8.4	8.4	-6	9	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	71183	2833	None	19	Human	Binding	pIC50	=	8.4	8.4	-6	9	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	CHEMBL1354199	2833	None	19	Human	Binding	pIC50	=	8.4	8.4	-6	9	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	CHEMBL3140030	2833	None	19	Human	Binding	pIC50	=	8.4	8.4	-6	9	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	CHEMBL376897	2833	None	19	Human	Binding	pIC50	=	8.4	8.4	-6	9	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	DB00462	2833	None	19	Human	Binding	pIC50	=	8.4	8.4	-6	9	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	11306852	14023	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
	CHEMBL1197250	14023	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
	CHEMBL563996	14023	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
	11539632	70559	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	CHEMBL194837	70559	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	9946010	62338	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779034	62338	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	10053614	120878	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401651	120878	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559203	120878	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	14075467	101478	None	0	Rat	Binding	pIC50	=	7.4	7.4	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL297818	101478	None	0	Rat	Binding	pIC50	=	7.4	7.4	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14075467	101478	None	0	Rat	Binding	pIC50	=	7.4	7.4	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL297818	101478	None	0	Rat	Binding	pIC50	=	7.4	7.4	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	107867	2972	None	55	Rat	Binding	pIC50	=	6.4	6.4	-14	11	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	309	2972	None	55	Rat	Binding	pIC50	=	6.4	6.4	-14	11	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	CHEMBL17045	2972	None	55	Rat	Binding	pIC50	=	6.4	6.4	-14	11	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	302	2975	None	25	Human	Binding	pIC50	=	6.4	6.4	-34	8	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
	4630	2975	None	25	Human	Binding	pIC50	=	6.4	6.4	-34	8	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
	CHEMBL7634	2975	None	25	Human	Binding	pIC50	=	6.4	6.4	-34	8	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
	3071778	163283	None	3	Mouse	Binding	pIC50	=	6.4	6.4	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	466	18	0	6	6.9	CN(C)Cc1ccc(CSCCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL418712	163283	None	3	Mouse	Binding	pIC50	=	6.4	6.4	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	466	18	0	6	6.9	CN(C)Cc1ccc(CSCCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	3072509	5570	None	3	Rat	Binding	pIC50	=	6.4	6.4	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3cccnc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL107673	5570	None	3	Rat	Binding	pIC50	=	6.4	6.4	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3cccnc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	107867	2972	None	55	Rat	Binding	pIC50	=	6.4	6.4	-14	11	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	309	2972	None	55	Rat	Binding	pIC50	=	6.4	6.4	-14	11	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	CHEMBL17045	2972	None	55	Rat	Binding	pIC50	=	6.4	6.4	-14	11	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	10333583	206048	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL85264	206048	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	10686988	12187	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
	CHEMBL1184244	12187	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
	CHEMBL340780	12187	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
	155522355	176407	None	0	Human	Binding	pIC50	=	7.4	7.4	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176407	None	0	Human	Binding	pIC50	=	7.4	7.4	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176407	None	0	Human	Binding	pIC50	=	7.4	7.4	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	10852843	11922	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1182713	11922	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL262303	11922	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	44304805	203020	None	0	Rat	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
	CHEMBL345233	203020	None	0	Rat	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
	CHEMBL63325	203020	None	0	Rat	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
	10132599	62336	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	5	0	3	4.0	O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779032	62336	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	5	0	3	4.0	O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	10755733	11426	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	CHEMBL1180297	11426	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	CHEMBL120581	11426	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	4189	206920	None	96	Human	Binding	pIC50	=	5.4	5.4	-18	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206920	None	96	Human	Binding	pIC50	=	5.4	5.4	-18	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206920	None	96	Human	Binding	pIC50	=	5.4	5.4	-18	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	23724781	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	316	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	317	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	71183	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL1354199	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL3140030	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL376897	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	DB00462	2833	None	19	Human	Binding	pIC50	=	6.4	6.4	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	44275682	11989	None	0	Rat	Binding	pIC50	=	6.4	6.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1183197	11989	None	0	Rat	Binding	pIC50	=	6.4	6.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL284208	11989	None	0	Rat	Binding	pIC50	=	6.4	6.4	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	3072514	5417	None	3	Rat	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	489	12	2	9	5.4	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccc(F)cc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL107254	5417	None	3	Rat	Binding	pIC50	=	5.4	5.4	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	489	12	2	9	5.4	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccc(F)cc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	19718	204822	None	7	Rat	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	2	0	2	0.0	CC(=O)N(C)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	CHEMBL75358	204822	None	7	Rat	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	2	0	2	0.0	CC(=O)N(C)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	9308	17752	None	21	Human	Binding	pIC50	=	6.4	6.4	2	7	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17752	None	21	Human	Binding	pIC50	=	6.4	6.4	2	7	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17752	None	21	Human	Binding	pIC50	=	6.4	6.4	2	7	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17752	None	21	Human	Binding	pIC50	=	6.4	6.4	2	7	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	10688349	12134	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184138	12134	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL334194	12134	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	54583840	62349	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	404	4	0	3	4.7	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2CN3CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779045	62349	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	404	4	0	3	4.7	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2CN3CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	10591874	13314	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1192001	13314	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL543177	13314	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	2230	465	None	60	Human	Binding	pIC50	=	5.4	5.4	-75	10	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
	296	465	None	60	Human	Binding	pIC50	=	5.4	5.4	-75	10	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
	CHEMBL7303	465	None	60	Human	Binding	pIC50	=	5.4	5.4	-75	10	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
	DB04365	465	None	60	Human	Binding	pIC50	=	5.4	5.4	-75	10	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
	11811722	10063	None	0	Human	Binding	pIC50	=	5.3	5.3	-	0	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	413	5	1	4	4.4	O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2	10.1021/jm010878g
	CHEMBL115280	10063	None	0	Human	Binding	pIC50	=	5.3	5.3	-	0	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	413	5	1	4	4.4	O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2	10.1021/jm010878g
	5310989	200875	None	0	Human	Binding	pIC50	=	5.3	5.3	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	3	1	5	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL60142	200875	None	0	Human	Binding	pIC50	=	5.3	5.3	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	3	1	5	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	3042	1413	None	35	Human	Binding	pIC50	=	7.3	7.3	-28	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	355	1413	None	35	Human	Binding	pIC50	=	7.3	7.3	-28	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	868	1413	None	35	Human	Binding	pIC50	=	7.3	7.3	-28	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	CHEMBL1123	1413	None	35	Human	Binding	pIC50	=	7.3	7.3	-28	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	DB00804	1413	None	35	Human	Binding	pIC50	=	7.3	7.3	-28	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	44275680	11161	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1178406	11161	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL26932	11161	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	10660	14414	None	58	Human	Binding	pIC50	=	6.3	6.3	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	441281	14414	None	58	Human	Binding	pIC50	=	6.3	6.3	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	CHEMBL1200406	14414	None	58	Human	Binding	pIC50	=	6.3	6.3	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	DB00985	14414	None	58	Human	Binding	pIC50	=	6.3	6.3	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	10826990	206154	None	0	Human	Binding	pIC50	=	4.3	4.3	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	285	3	0	5	1.7	O=[N+]([O-])c1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL86197	206154	None	0	Human	Binding	pIC50	=	4.3	4.3	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	285	3	0	5	1.7	O=[N+]([O-])c1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	44302879	202716	None	0	Human	Binding	pIC50	=	5.3	5.3	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	348	1	1	4	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL61774	202716	None	0	Human	Binding	pIC50	=	5.3	5.3	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	348	1	1	4	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
	10522202	11432	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1180312	11432	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL121385	11432	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	44303018	202021	None	0	Rat	Binding	pIC50	=	7.3	7.3	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60833	202021	None	0	Rat	Binding	pIC50	=	7.3	7.3	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	3055247	18929	None	6	Mouse	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	478	14	2	8	3.2	CN(C)Cc1ccc(CSCCNC(=NC#N)NCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL12858	18929	None	6	Mouse	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	478	14	2	8	3.2	CN(C)Cc1ccc(CSCCNC(=NC#N)NCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	10755732	12119	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1184092	12119	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL332181	12119	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	5747382	109201	None	3	Rat	Binding	pIC50	=	5.3	5.3	-	1	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL321605	109201	None	3	Rat	Binding	pIC50	=	5.3	5.3	-	1	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	10549581	11447	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	CHEMBL1180349	11447	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	CHEMBL123198	11447	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	135398737	957	None	93	Human	Binding	pIC50	=	6.3	6.3	-22	91	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	957	None	93	Human	Binding	pIC50	=	6.3	6.3	-22	91	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	957	None	93	Human	Binding	pIC50	=	6.3	6.3	-22	91	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	957	None	93	Human	Binding	pIC50	=	6.3	6.3	-22	91	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	957	None	93	Human	Binding	pIC50	=	6.3	6.3	-22	91	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	167962	4067	None	4	Human	Binding	pIC50	=	6.3	6.3	-	1	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4067	None	4	Human	Binding	pIC50	=	6.3	6.3	-	1	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4067	None	4	Human	Binding	pIC50	=	6.3	6.3	-	1	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	10563152	206068	None	0	Human	Binding	pIC50	=	4.3	4.3	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL85460	206068	None	0	Human	Binding	pIC50	=	4.3	4.3	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	72548703	161565	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	CHEMBL4128926	161565	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	10082470	52715	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
	CHEMBL15944	52715	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
	CHEMBL308608	52715	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
	9804849	67454	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	CHEMBL189118	67454	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	44275626	11163	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1178434	11163	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL28033	11163	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	10522336	15128	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.3	CCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL120972	15128	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.3	CCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	44303397	102286	None	0	Rat	Binding	pIC50	=	7.3	7.3	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL303360	102286	None	0	Rat	Binding	pIC50	=	7.3	7.3	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	9308	17752	None	21	Rat	Binding	pIC50	=	6.3	6.3	-2	7	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17752	None	21	Rat	Binding	pIC50	=	6.3	6.3	-2	7	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17752	None	21	Rat	Binding	pIC50	=	6.3	6.3	-2	7	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17752	None	21	Rat	Binding	pIC50	=	6.3	6.3	-2	7	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	44275680	11161	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1178406	11161	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL26932	11161	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	107867	2972	None	55	Rat	Binding	pIC50	=	7.3	7.3	-14	11	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	309	2972	None	55	Rat	Binding	pIC50	=	7.3	7.3	-14	11	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	CHEMBL17045	2972	None	55	Rat	Binding	pIC50	=	7.3	7.3	-14	11	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	14054139	161765	None	0	Rat	Binding	pIC50	=	7.3	7.3	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	336	2	1	4	2.7	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
	CHEMBL413966	161765	None	0	Rat	Binding	pIC50	=	7.3	7.3	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	336	2	1	4	2.7	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
	107867	2972	None	55	Rat	Binding	pIC50	=	7.3	7.3	-14	11	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	309	2972	None	55	Rat	Binding	pIC50	=	7.3	7.3	-14	11	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	CHEMBL17045	2972	None	55	Rat	Binding	pIC50	=	7.3	7.3	-14	11	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	52950036	19156	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	391	3	0	5	3.3	O=C(c1cscn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289544	19156	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	391	3	0	5	3.3	O=C(c1cscn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	52943879	19347	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	388	3	0	4	3.7	Cc1ccc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)o1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290753	19347	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	388	3	0	4	3.7	Cc1ccc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)o1	10.1016/j.bmcl.2010.10.016
	11569926	63131	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779048	63131	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789434	63131	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	14054137	98883	None	0	Rat	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	338	5	1	4	3.0	CN(C)CCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	CHEMBL279135	98883	None	0	Rat	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	338	5	1	4	3.0	CN(C)CCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	44268378	21949	None	0	Mouse	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	497	17	2	10	3.4	CN(C)Cc1ccc(CSCCN/C=C(/NCCSCc2ccc(CN(C)C)o2)[N+](=O)[O-])o1	10.1021/jm00084a015
	CHEMBL13206	21949	None	0	Mouse	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	497	17	2	10	3.4	CN(C)Cc1ccc(CSCCN/C=C(/NCCSCc2ccc(CN(C)C)o2)[N+](=O)[O-])o1	10.1021/jm00084a015
	14590394	180884	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL47575	180884	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14590394	180884	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL47575	180884	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	23724781	2833	None	19	Human	Binding	pIC50	=	6.3	6.3	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	316	2833	None	19	Human	Binding	pIC50	=	6.3	6.3	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	317	2833	None	19	Human	Binding	pIC50	=	6.3	6.3	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	71183	2833	None	19	Human	Binding	pIC50	=	6.3	6.3	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL1354199	2833	None	19	Human	Binding	pIC50	=	6.3	6.3	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL3140030	2833	None	19	Human	Binding	pIC50	=	6.3	6.3	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL376897	2833	None	19	Human	Binding	pIC50	=	6.3	6.3	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	DB00462	2833	None	19	Human	Binding	pIC50	=	6.3	6.3	-6	9	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	176	398	None	66	Human	Binding	pIC50	=	5.3	5.3	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	398	None	66	Human	Binding	pIC50	=	5.3	5.3	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	398	None	66	Human	Binding	pIC50	=	5.3	5.3	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	398	None	66	Human	Binding	pIC50	=	5.3	5.3	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	398	None	66	Human	Binding	pIC50	=	5.3	5.3	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	154734599	2501	None	12	Human	Binding	pIC50	=	7.3	7.3	1	12	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	327	2501	None	12	Human	Binding	pIC50	=	7.3	7.3	1	12	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	4108	2501	None	12	Human	Binding	pIC50	=	7.3	7.3	1	12	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	CHEMBL27673	2501	None	12	Human	Binding	pIC50	=	7.3	7.3	1	12	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	10937901	9908	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
	CHEMBL114379	9908	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
	10058347	105929	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL312823	105929	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	10035533	205701	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2	ChEMBL	194	3	0	3	1.7	CC(C)=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL82378	205701	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2	ChEMBL	194	3	0	3	1.7	CC(C)=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	10854880	11419	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1180282	11419	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL120080	11419	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	3071774	21546	None	3	Mouse	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	410	14	0	6	5.3	CN(C)Cc1ccc(CSCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL13166	21546	None	3	Mouse	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	410	14	0	6	5.3	CN(C)Cc1ccc(CSCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	1726	2495	None	13	Rat	Binding	pIC50	=	5.3	5.3	-3	5	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2495	None	13	Rat	Binding	pIC50	=	5.3	5.3	-3	5	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2495	None	13	Rat	Binding	pIC50	=	5.3	5.3	-3	5	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2495	None	13	Rat	Binding	pIC50	=	5.3	5.3	-3	5	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2495	None	13	Rat	Binding	pIC50	=	5.3	5.3	-3	5	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1726	2495	None	13	Human	Binding	pIC50	=	5.3	5.3	-2	5	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2495	None	13	Human	Binding	pIC50	=	5.3	5.3	-2	5	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2495	None	13	Human	Binding	pIC50	=	5.3	5.3	-2	5	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2495	None	13	Human	Binding	pIC50	=	5.3	5.3	-2	5	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2495	None	13	Human	Binding	pIC50	=	5.3	5.3	-2	5	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	5487543	205644	None	4	Human	Binding	pIC50	=	4.3	4.3	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL81878	205644	None	4	Human	Binding	pIC50	=	4.3	4.3	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	43815	186918	None	64	Human	Binding	pIC50	=	6.3	6.3	-15	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	CHEMBL1708	186918	None	64	Human	Binding	pIC50	=	6.3	6.3	-15	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	CHEMBL490	186918	None	64	Human	Binding	pIC50	=	6.3	6.3	-15	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	3071777	163284	None	3	Mouse	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	452	17	0	6	6.5	CN(C)Cc1ccc(CSCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL418714	163284	None	3	Mouse	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	452	17	0	6	6.5	CN(C)Cc1ccc(CSCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	10636001	11423	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1180290	11423	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL120329	11423	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	5648	78409	None	9	Human	Binding	pIC50	=	7.3	7.3	-2	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	CHEMBL2107687	78409	None	9	Human	Binding	pIC50	=	7.3	7.3	-2	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	CHEMBL2111176	78409	None	9	Human	Binding	pIC50	=	7.3	7.3	-2	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	1734	116	None	10	Human	Binding	pIC50	=	7.3	7.3	-9	13	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	307	116	None	10	Human	Binding	pIC50	=	7.3	7.3	-9	13	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	CHEMBL168067	116	None	10	Human	Binding	pIC50	=	7.3	7.3	-9	13	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	3071779	16820	None	3	Mouse	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	444	12	0	6	5.9	CN(C)Cc1ccc(CSCc2ccc(CSCc3ccc(CN(C)C)o3)cc2)o1	10.1021/jm00084a015
	CHEMBL12472	16820	None	3	Mouse	Binding	pIC50	=	6.3	6.3	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	444	12	0	6	5.9	CN(C)Cc1ccc(CSCc2ccc(CSCc3ccc(CN(C)C)o3)cc2)o1	10.1021/jm00084a015
	15685982	56524	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	3	1	3	1.6	CC(/C=N/O)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	CHEMBL163661	56524	None	0	Rat	Binding	pIC50	=	5.3	5.3	-	0	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	3	1	3	1.6	CC(/C=N/O)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	13578552	160175	None	0	Rat	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00128a008
	CHEMBL410928	160175	None	0	Rat	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00128a008
	13578552	160175	None	0	Rat	Binding	pIC50	=	6.3	6.3	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00048a014
	CHEMBL410928	160175	None	0	Rat	Binding	pIC50	=	6.3	6.3	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00048a014
	9905467	11434	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1180316	11434	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL121520	11434	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	6075	150106	None	42	Human	Binding	pIC50	=	6.3	6.3	-7	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	CHEMBL395110	150106	None	42	Human	Binding	pIC50	=	6.3	6.3	-7	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	3072501	107267	None	6	Rat	Binding	pIC50	=	5.2	5.2	-	1	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL316973	107267	None	6	Rat	Binding	pIC50	=	5.2	5.2	-	1	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	154059	3635	None	51	Human	Binding	pIC50	=	6.2	6.2	-12	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	2457	3635	None	51	Human	Binding	pIC50	=	6.2	6.2	-12	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	7483	3635	None	51	Human	Binding	pIC50	=	6.2	6.2	-12	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	CHEMBL1734	3635	None	51	Human	Binding	pIC50	=	6.2	6.2	-12	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	DB01591	3635	None	51	Human	Binding	pIC50	=	6.2	6.2	-12	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	2335	11846	None	22	Human	Binding	pIC50	=	6.2	6.2	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	8478	11846	None	22	Human	Binding	pIC50	=	6.2	6.2	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	CHEMBL1182210	11846	None	22	Human	Binding	pIC50	=	6.2	6.2	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	CHEMBL221753	11846	None	22	Human	Binding	pIC50	=	6.2	6.2	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	3071775	97214	None	3	Mouse	Binding	pIC50	=	6.2	6.2	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	424	15	0	6	5.7	CN(C)Cc1ccc(CSCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL268499	97214	None	3	Mouse	Binding	pIC50	=	6.2	6.2	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	424	15	0	6	5.7	CN(C)Cc1ccc(CSCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	3071771	21092	None	3	Mouse	Binding	pIC50	=	6.2	6.2	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	592	18	2	12	5.5	CN(C)Cc1ccc(CSCCNc2cc(NCCSCc3ccc(CN(C)C)o3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00084a015
	CHEMBL13122	21092	None	3	Mouse	Binding	pIC50	=	6.2	6.2	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	592	18	2	12	5.5	CN(C)Cc1ccc(CSCCNc2cc(NCCSCc3ccc(CN(C)C)o3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00084a015
	2230	465	None	60	Rat	Binding	pIC50	=	6.2	6.2	-107	10	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	296	465	None	60	Rat	Binding	pIC50	=	6.2	6.2	-107	10	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	CHEMBL7303	465	None	60	Rat	Binding	pIC50	=	6.2	6.2	-107	10	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	DB04365	465	None	60	Rat	Binding	pIC50	=	6.2	6.2	-107	10	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	44575653	181642	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	327	14	7	4	0.4	N=C(N)NCCCCCCCCC(=O)C(N)CCCNC(=N)N	10.1021/np50120a004
	CHEMBL477542	181642	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	327	14	7	4	0.4	N=C(N)NCCCCCCCCC(=O)C(N)CCCNC(=N)N	10.1021/np50120a004
	52943696	19263	None	3	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	348	3	0	2	4.2	O=C(c1ccccc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290294	19263	None	3	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	348	3	0	2	4.2	O=C(c1ccccc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	14374296	101651	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL299142	101651	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	13578554	172423	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00128a008
	CHEMBL44773	172423	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00128a008
	14374296	101651	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL299142	101651	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	13578554	172423	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00048a014
	CHEMBL44773	172423	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00048a014
	6410685	109254	None	3	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	337	9	1	8	2.4	CN(C)Cc1ccc(CSCCNc2nnccc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL321808	109254	None	3	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	337	9	1	8	2.4	CN(C)Cc1ccc(CSCCNc2nnccc2[N+](=O)[O-])o1	10.1021/jm00095a008
	13578555	176678	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00128a008
	CHEMBL45983	176678	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00128a008
	14590399	101276	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL296365	101276	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14054144	60431	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	337	0	1	4	2.2	CN1CCN(C(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL17519	60431	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	337	0	1	4	2.2	CN1CCN(C(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	14590399	101276	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL296365	101276	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	13578555	176678	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00048a014
	CHEMBL45983	176678	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00048a014
	10851853	12186	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1184242	12186	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL340561	12186	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	71450872	78677	None	0	Rat	Binding	pIC50	=	5.2	5.2	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL2112418	78677	None	0	Rat	Binding	pIC50	=	5.2	5.2	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	10058744	206380	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL87622	206380	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	10397133	107060	None	1	Human	Binding	pIC50	=	5.2	5.2	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL315676	107060	None	1	Human	Binding	pIC50	=	5.2	5.2	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	10487582	28227	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	CHEMBL137384	28227	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	24180125	95654	None	71	Human	Binding	pIC50	=	5.2	5.2	-	0	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
	CHEMBL257991	95654	None	71	Human	Binding	pIC50	=	5.2	5.2	-	0	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
	44303017	200831	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60101	200831	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	52947553	19106	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccoc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289202	19106	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccoc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	122203596	155804	None	0	Human	Binding	pIC50	=	6.2	6.2	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pIC50	=	6.2	6.2	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pIC50	=	6.2	6.2	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	3072513	6260	None	4	Rat	Binding	pIC50	=	5.2	5.2	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	471	12	2	9	5.2	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL108163	6260	None	4	Rat	Binding	pIC50	=	5.2	5.2	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	471	12	2	9	5.2	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	78319901	159232	None	35	Human	Binding	pIC50	=	5.2	5.2	-	0	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
	CHEMBL4098877	159232	None	35	Human	Binding	pIC50	=	5.2	5.2	-	0	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
	118728611	117777	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401644	117777	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
	60691	101549	None	26	Rat	Binding	pIC50	=	6.2	6.2	-	0	Inhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)PInhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)P	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
	CHEMBL29835	101549	None	26	Rat	Binding	pIC50	=	6.2	6.2	-	0	Inhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)PInhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)P	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
	15685977	120341	None	0	Rat	Binding	pIC50	=	5.2	5.2	-	0	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	193	3	0	2	1.7	CC(=O)C(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	CHEMBL353023	120341	None	0	Rat	Binding	pIC50	=	5.2	5.2	-	0	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	193	3	0	2	1.7	CC(=O)C(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	2726	918	None	68	Human	Binding	pIC50	=	6.2	6.2	-79	73	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	918	None	68	Human	Binding	pIC50	=	6.2	6.2	-79	73	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	918	None	68	Human	Binding	pIC50	=	6.2	6.2	-79	73	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	918	None	68	Human	Binding	pIC50	=	6.2	6.2	-79	73	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	918	None	68	Human	Binding	pIC50	=	6.2	6.2	-79	73	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	137630050	161038	None	0	Human	Binding	pIC50	=	5.2	5.2	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pIC50	=	5.2	5.2	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pIC50	=	5.2	5.2	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pIC50	=	5.2	5.2	1	5	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	10499832	12133	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184134	12133	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL334093	12133	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	10782462	12112	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1184068	12112	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL330999	12112	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	14660293	52651	None	3	Human	Binding	pIC50	=	5.2	5.2	-	0	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	191	0	1	4	1.3	c1cc2nsnc2c2c1CCNC2	10.1021/jm9705216
	CHEMBL15936	52651	None	3	Human	Binding	pIC50	=	5.2	5.2	-	0	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	191	0	1	4	1.3	c1cc2nsnc2c2c1CCNC2	10.1021/jm9705216
	3072504	5810	None	7	Rat	Binding	pIC50	=	5.2	5.2	-	1	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL107892	5810	None	7	Rat	Binding	pIC50	=	5.2	5.2	-	1	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	44333819	4711	None	0	Rat	Binding	pIC50	=	5.2	5.2	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2ccccc2N(C(=O)CC2CCCN3CCCCC23)c2ncccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL103529	4711	None	0	Rat	Binding	pIC50	=	5.2	5.2	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2ccccc2N(C(=O)CC2CCCN3CCCCC23)c2ncccc21	10.1016/s0960-894x(99)00528-4
	2200	3129	None	46	Rat	Binding	pIC50	=	6.2	6.2	-31	13	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
	328	3129	None	46	Rat	Binding	pIC50	=	6.2	6.2	-31	13	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
	4848	3129	None	46	Rat	Binding	pIC50	=	6.2	6.2	-31	13	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
	CHEMBL9967	3129	None	46	Rat	Binding	pIC50	=	6.2	6.2	-31	13	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
	DB00670	3129	None	46	Rat	Binding	pIC50	=	6.2	6.2	-31	13	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
	10707175	206149	None	0	Human	Binding	pIC50	=	4.2	4.2	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL86150	206149	None	0	Human	Binding	pIC50	=	4.2	4.2	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	1210	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	1213	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	2725	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	33036	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	4411	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	616	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	6976	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	716121	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL1201353	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL1554789	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL505	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	DB01114	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	DB13679	917	None	51	Human	Binding	pIC50	=	5.2	5.2	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	10187216	63136	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779128	63136	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789452	63136	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	14590402	101085	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL294919	101085	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14590402	101085	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL294919	101085	None	0	Rat	Binding	pIC50	=	7.2	7.2	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	13269694	59446	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL17120	59446	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	14054135	61516	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	296	2	1	4	1.9	CN(C)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	CHEMBL17709	61516	None	0	Rat	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	296	2	1	4	1.9	CN(C)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	10511551	25829	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	CHEMBL135328	25829	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	3072502	4924	None	13	Rat	Binding	pIC50	=	5.2	5.2	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	398	10	1	8	3.6	CN(C)Cc1ccc(CSCCNc2cc(F)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL104681	4924	None	13	Rat	Binding	pIC50	=	5.2	5.2	-	0	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	398	10	1	8	3.6	CN(C)Cc1ccc(CSCCNc2cc(F)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	24871823	92527	None	5	Human	Binding	pIC50	=	5.2	5.2	-	0	Inhibition of muscarinic 2 receptor (unknown origin)Inhibition of muscarinic 2 receptor (unknown origin)	ChEMBL	355	3	0	7	3.2	C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cnn(C)c3)nn12	10.1021/jm400926x
	CHEMBL2431819	92527	None	5	Human	Binding	pIC50	=	5.2	5.2	-	0	Inhibition of muscarinic 2 receptor (unknown origin)Inhibition of muscarinic 2 receptor (unknown origin)	ChEMBL	355	3	0	7	3.2	C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cnn(C)c3)nn12	10.1021/jm400926x
	3071776	24547	None	3	Mouse	Binding	pIC50	=	6.2	6.2	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	438	16	0	6	6.1	CN(C)Cc1ccc(CSCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL13426	24547	None	3	Mouse	Binding	pIC50	=	6.2	6.2	-	0	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	438	16	0	6	6.1	CN(C)Cc1ccc(CSCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	10806268	12135	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1184139	12135	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL334245	12135	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	15181802	12163	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
	CHEMBL1184199	12163	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
	CHEMBL338611	12163	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
	10666533	11430	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	CHEMBL1180310	11430	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	CHEMBL121299	11430	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	14058518	11160	None	0	Rat	Binding	pIC50	=	4.1	4.1	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	CHEMBL1178388	11160	None	0	Rat	Binding	pIC50	=	4.1	4.1	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	CHEMBL25649	11160	None	0	Rat	Binding	pIC50	=	4.1	4.1	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	10592484	11433	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1180314	11433	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL121476	11433	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	1212	1660	None	50	Human	Binding	pIC50	=	5.1	5.1	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1660	None	50	Human	Binding	pIC50	=	5.1	5.1	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1660	None	50	Human	Binding	pIC50	=	5.1	5.1	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1660	None	50	Human	Binding	pIC50	=	5.1	5.1	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1660	None	50	Human	Binding	pIC50	=	5.1	5.1	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	11256587	2460	None	59	Human	Binding	pIC50	=	5.1	5.1	-	1	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
	8580	2460	None	59	Human	Binding	pIC50	=	5.1	5.1	-	1	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
	CHEMBL518924	2460	None	59	Human	Binding	pIC50	=	5.1	5.1	-	1	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
	DB05501	2460	None	59	Human	Binding	pIC50	=	5.1	5.1	-	1	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
	9966959	62345	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	6	0	4	3.6	CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	CHEMBL1779041	62345	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	6	0	4	3.6	CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	44333822	4663	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	406	2	1	4	4.8	O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL103189	4663	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	406	2	1	4	4.8	O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	10048670	107456	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	436	4	1	5	4.3	O=C1Nc2cccnc2N(C(=O)CSCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL318316	107456	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	436	4	1	5	4.3	O=C1Nc2cccnc2N(C(=O)CSCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	57345320	3830	None	9	Human	Binding	pIC50	=	5.1	5.1	-	0	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
	9882	3830	None	9	Human	Binding	pIC50	=	5.1	5.1	-	0	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
	CHEMBL3091687	3830	None	9	Human	Binding	pIC50	=	5.1	5.1	-	0	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
	3055	1432	None	44	Human	Binding	pIC50	=	6.1	6.1	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	313	1432	None	44	Human	Binding	pIC50	=	6.1	6.1	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	7163	1432	None	44	Human	Binding	pIC50	=	6.1	6.1	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	CHEMBL936	1432	None	44	Human	Binding	pIC50	=	6.1	6.1	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	DB01231	1432	None	44	Human	Binding	pIC50	=	6.1	6.1	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	44302755	202674	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	408	4	1	6	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL61494	202674	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	408	4	1	6	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	10854879	11415	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1180239	11415	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL118241	11415	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	1273	1752	None	16	Human	Binding	pIC50	=	6.1	6.1	-1	3	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	3450	1752	None	16	Human	Binding	pIC50	=	6.1	6.1	-1	3	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	356	1752	None	16	Human	Binding	pIC50	=	6.1	6.1	-1	3	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	6172	1752	None	16	Human	Binding	pIC50	=	6.1	6.1	-1	3	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	67425	1752	None	16	Human	Binding	pIC50	=	6.1	6.1	-1	3	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	CHEMBL360055	1752	None	16	Human	Binding	pIC50	=	6.1	6.1	-1	3	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	DB00483	1752	None	16	Human	Binding	pIC50	=	6.1	6.1	-1	3	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	1016	3745	None	78	Human	Binding	pIC50	=	5.1	5.1	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3745	None	78	Human	Binding	pIC50	=	5.1	5.1	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3745	None	78	Human	Binding	pIC50	=	5.1	5.1	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3745	None	78	Human	Binding	pIC50	=	5.1	5.1	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3745	None	78	Human	Binding	pIC50	=	5.1	5.1	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3745	None	78	Human	Binding	pIC50	=	5.1	5.1	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	3191	102856	None	97	Human	Binding	pIC50	=	6.1	6.1	-8	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	CHEMBL305660	102856	None	97	Human	Binding	pIC50	=	6.1	6.1	-8	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	DB11742	102856	None	97	Human	Binding	pIC50	=	6.1	6.1	-8	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	44303293	201424	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60479	201424	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	44235638	195312	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	347	2	0	3	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2CCc2ccccc21	10.1021/jm900132z
	CHEMBL551525	195312	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	347	2	0	3	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2CCc2ccccc21	10.1021/jm900132z
	52945165	19139	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	375	3	0	5	2.8	O=C(c1ccon1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289432	19139	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	375	3	0	5	2.8	O=C(c1ccon1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	52942497	19264	None	3	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	349	3	0	3	3.6	O=C(c1cccnc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290295	19264	None	3	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	349	3	0	3	3.6	O=C(c1cccnc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	3233138	19286	None	2	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	338	3	0	3	3.8	O=C(c1ccco1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290409	19286	None	2	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	338	3	0	3	3.8	O=C(c1ccco1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	52949883	19324	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	5	0	3	4.6	CCOc1ccccc1C(=O)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290634	19324	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	5	0	3	4.6	CCOc1ccccc1C(=O)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	57396813	71543	None	0	Human	Binding	pIC50	=	5.1	5.1	-	5	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	CHEMBL1949930	71543	None	0	Human	Binding	pIC50	=	5.1	5.1	-	5	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	CHEMBL1963007	71543	None	0	Human	Binding	pIC50	=	5.1	5.1	-	5	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	10085070	205982	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL84726	205982	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	52946068	19231	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	413	4	0	5	4.1	Cc1ccccc1CN1CCC2(CC1)CN(C(=O)c1csc(C(C)C)n1)CCO2	10.1016/j.bmcl.2010.10.016
	CHEMBL1290077	19231	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	413	4	0	5	4.1	Cc1ccccc1CN1CCC2(CC1)CN(C(=O)c1csc(C(C)C)n1)CCO2	10.1016/j.bmcl.2010.10.016
	52947416	19304	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	341	2	0	3	3.2	O=C(N1CCC2(CCN(Cc3ccccc3)CC2)CC1)N1CC=CO1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290519	19304	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	341	2	0	3	3.2	O=C(N1CCC2(CCN(Cc3ccccc3)CC2)CC1)N1CC=CO1	10.1016/j.bmcl.2010.10.016
	46891488	7171	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	328	4	2	2	3.7	O=C(NCC1CCNCC1)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
	CHEMBL1085507	7171	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	328	4	2	2	3.7	O=C(NCC1CCNCC1)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
	14054142	59516	None	0	Rat	Binding	pIC50	=	8.1	8.1	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.2	CN1CCCCC1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	CHEMBL17155	59516	None	0	Rat	Binding	pIC50	=	8.1	8.1	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.2	CN1CCCCC1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	10143858	63137	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779132	63137	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789454	63137	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	10164137	63124	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779137	63124	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789386	63124	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	2200	3129	None	46	Rat	Binding	pIC50	=	6.1	6.1	-31	13	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
	328	3129	None	46	Rat	Binding	pIC50	=	6.1	6.1	-31	13	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
	4848	3129	None	46	Rat	Binding	pIC50	=	6.1	6.1	-31	13	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
	CHEMBL9967	3129	None	46	Rat	Binding	pIC50	=	6.1	6.1	-31	13	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
	DB00670	3129	None	46	Rat	Binding	pIC50	=	6.1	6.1	-31	13	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
	14590395	101516	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00128a008
	CHEMBL298078	101516	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00128a008
	14590395	101516	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00048a014
	CHEMBL298078	101516	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00048a014
	16005860	187404	None	7	Human	Binding	pIC50	=	5.1	5.1	-	0	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	388	5	1	2	4.8	CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1	10.1021/jm800830n
	CHEMBL493677	187404	None	7	Human	Binding	pIC50	=	5.1	5.1	-	0	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	388	5	1	2	4.8	CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1	10.1021/jm800830n
	67547662	120883	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401653	120883	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559210	120883	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
	42636350	82591	None	41	Human	Binding	pIC50	=	4.1	4.1	-	0	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	367	5	2	4	3.6	Cc1nc(C)c(-c2ccc([C@H]3CC[C@H](CC(=O)O)CC3)cc2)nc1C(N)=O	10.1021/jm301296t
	CHEMBL2178953	82591	None	41	Human	Binding	pIC50	=	4.1	4.1	-	0	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	367	5	2	4	3.6	Cc1nc(C)c(-c2ccc([C@H]3CC[C@H](CC(=O)O)CC3)cc2)nc1C(N)=O	10.1021/jm301296t
	9990434	106337	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL313918	106337	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	180	401	None	56	Human	Binding	pIC50	=	7.1	7.1	-27	40	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	200	401	None	56	Human	Binding	pIC50	=	7.1	7.1	-27	40	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	2160	401	None	56	Human	Binding	pIC50	=	7.1	7.1	-27	40	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	CHEMBL629	401	None	56	Human	Binding	pIC50	=	7.1	7.1	-27	40	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	DB00321	401	None	56	Human	Binding	pIC50	=	7.1	7.1	-27	40	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	1530	2180	None	50	Human	Binding	pIC50	=	6.1	6.1	-43	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	3827	2180	None	50	Human	Binding	pIC50	=	6.1	6.1	-43	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	7206	2180	None	50	Human	Binding	pIC50	=	6.1	6.1	-43	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	CHEMBL534	2180	None	50	Human	Binding	pIC50	=	6.1	6.1	-43	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	DB00920	2180	None	50	Human	Binding	pIC50	=	6.1	6.1	-43	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	10778462	206006	None	0	Human	Binding	pIC50	=	4.1	4.1	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	CHEMBL84919	206006	None	0	Human	Binding	pIC50	=	4.1	4.1	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	302	2975	None	25	Rat	Binding	pIC50	=	6.1	6.1	-4	8	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	4630	2975	None	25	Rat	Binding	pIC50	=	6.1	6.1	-4	8	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	CHEMBL7634	2975	None	25	Rat	Binding	pIC50	=	6.1	6.1	-4	8	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	302	2975	None	25	Rat	Binding	pIC50	=	6.1	6.1	-4	8	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
	4630	2975	None	25	Rat	Binding	pIC50	=	6.1	6.1	-4	8	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
	CHEMBL7634	2975	None	25	Rat	Binding	pIC50	=	6.1	6.1	-4	8	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
	44265375	206145	None	0	Rat	Binding	pIC50	=	5.1	5.1	-	0	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL8610	206145	None	0	Rat	Binding	pIC50	=	5.1	5.1	-	0	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL5070958	214247	None	3	Human	Binding	pIC50	=	5.1	5.1	-	0	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2ncccc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
	54584800	62343	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	356	5	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779039	62343	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	356	5	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
	2166	3121	None	49	Rat	Binding	pIC50	=	5.1	5.1	-4	8	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	305	3121	None	49	Rat	Binding	pIC50	=	5.1	5.1	-4	8	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	5910	3121	None	49	Rat	Binding	pIC50	=	5.1	5.1	-4	8	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	CHEMBL550	3121	None	49	Rat	Binding	pIC50	=	5.1	5.1	-4	8	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	DB01085	3121	None	49	Rat	Binding	pIC50	=	5.1	5.1	-4	8	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	10610448	206123	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1cccs1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL85936	206123	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1cccs1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	13271741	59530	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	2	5	1.7	CN1CCN(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL17162	59530	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	2	5	1.7	CN1CCN(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	13271742	59649	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	1	5	3.0	CN1CCC(OC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL17213	59649	None	0	Rat	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	1	5	3.0	CN1CCC(OC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	10392705	120879	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401652	120879	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559204	120879	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	2230	465	None	60	Rat	Binding	pIC50	=	5.0	5.0	-107	10	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
	296	465	None	60	Rat	Binding	pIC50	=	5.0	5.0	-107	10	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
	CHEMBL7303	465	None	60	Rat	Binding	pIC50	=	5.0	5.0	-107	10	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
	DB04365	465	None	60	Rat	Binding	pIC50	=	5.0	5.0	-107	10	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
	44303408	201944	None	0	Rat	Binding	pIC50	=	7.0	7.0	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60777	201944	None	0	Rat	Binding	pIC50	=	7.0	7.0	-	0	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	49853884	90681	None	0	Human	Binding	pIC50	=	4.0	4.0	-	0	Binding affinity to M2 receptor (unknown origin) by radioligand displacement assayBinding affinity to M2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	265	3	1	3	1.2	O=C(CN1CCN2CCC[C@H]2C1)NC1CCCCC1	10.1016/j.bmc.2013.02.058
	CHEMBL2391353	90681	None	0	Human	Binding	pIC50	=	4.0	4.0	-	0	Binding affinity to M2 receptor (unknown origin) by radioligand displacement assayBinding affinity to M2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	265	3	1	3	1.2	O=C(CN1CCN2CCC[C@H]2C1)NC1CCCCC1	10.1016/j.bmc.2013.02.058
	44302728	198711	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	422	4	1	6	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL58228	198711	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	422	4	1	6	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	14058518	11160	None	0	Rat	Binding	pIC50	=	5.0	5.0	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	CHEMBL1178388	11160	None	0	Rat	Binding	pIC50	=	5.0	5.0	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	CHEMBL25649	11160	None	0	Rat	Binding	pIC50	=	5.0	5.0	-	0	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	44302776	102348	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	376	2	1	4	4.4	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(C)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL303758	102348	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	376	2	1	4	4.4	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(C)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	10614695	12155	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184188	12155	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	CHEMBL338280	12155	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	10569816	11457	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	CHEMBL1180367	11457	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	CHEMBL124173	11457	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	10248541	182897	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	369	15	7	4	0.5	CC(=O)NC(CCCNC(=N)N)C(=O)CCCCCCCCNC(=N)N	10.1021/np50120a004
	CHEMBL479224	182897	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	369	15	7	4	0.5	CC(=O)NC(CCCNC(=N)N)C(=O)CCCCCCCCNC(=N)N	10.1021/np50120a004
	237	204863	None	48	Human	Binding	pIC50	=	6.0	6.0	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL546257	204863	None	48	Human	Binding	pIC50	=	6.0	6.0	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL554190	204863	None	48	Human	Binding	pIC50	=	6.0	6.0	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL7568	204863	None	48	Human	Binding	pIC50	=	6.0	6.0	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	2200	3129	None	46	Human	Binding	pIC50	=	6.0	6.0	-35	13	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
	328	3129	None	46	Human	Binding	pIC50	=	6.0	6.0	-35	13	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
	4848	3129	None	46	Human	Binding	pIC50	=	6.0	6.0	-35	13	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
	CHEMBL9967	3129	None	46	Human	Binding	pIC50	=	6.0	6.0	-35	13	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
	DB00670	3129	None	46	Human	Binding	pIC50	=	6.0	6.0	-35	13	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
	25147683	62350	None	37	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	408	4	0	3	4.5	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779046	62350	None	37	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	408	4	0	3	4.5	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	164612037	185375	None	0	Human	Binding	pKd	=	10	10.0	-1	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	CHEMBL4860528	185375	None	0	Human	Binding	pKd	=	10	10.0	-1	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	168290235	192966	None	0	Human	Binding	pKd	=	10	10.0	-6	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5201074	192966	None	0	Human	Binding	pKd	=	10	10.0	-6	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222491	192966	None	0	Human	Binding	pKd	=	10	10.0	-6	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	168294767	193017	None	0	Human	Binding	pKd	=	10	10.0	-1	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5207281	193017	None	0	Human	Binding	pKd	=	10	10.0	-1	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222802	193017	None	0	Human	Binding	pKd	=	10	10.0	-1	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	168295528	193029	None	0	Human	Binding	pKd	=	10	10.0	-1	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5206565	193029	None	0	Human	Binding	pKd	=	10	10.0	-1	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222872	193029	None	0	Human	Binding	pKd	=	10	10.0	-1	20	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	10457079	10028	None	0	Human	Binding	pKd	=	9.8	9.8	-4	2	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL115078	10028	None	0	Human	Binding	pKd	=	9.8	9.8	-4	2	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	688566	195881	None	24	Rat	Binding	pKd	=	9.7	9.7	-1	3	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00020a004
	CHEMBL558910	195881	None	24	Rat	Binding	pKd	=	9.7	9.7	-1	3	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00020a004
	137630050	161038	None	0	Human	Binding	pKd	=	9.7	9.7	1	5	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pKd	=	9.7	9.7	1	5	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pKd	=	9.7	9.7	1	5	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pKd	=	9.7	9.7	1	5	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	137630050	161038	None	0	Human	Binding	pKd	=	9.7	9.7	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pKd	=	9.7	9.7	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pKd	=	9.7	9.7	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pKd	=	9.7	9.7	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	137630050	161038	None	0	Human	Binding	pKd	=	9.5	9.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pKd	=	9.5	9.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pKd	=	9.5	9.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pKd	=	9.5	9.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	137630050	161038	None	0	Human	Binding	pKd	=	9.5	9.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pKd	=	9.5	9.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pKd	=	9.5	9.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pKd	=	9.5	9.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	10387775	78490	None	0	Rat	Binding	pKd	=	9.4	9.4	-3	2	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
	CHEMBL2111842	78490	None	0	Rat	Binding	pKd	=	9.4	9.4	-3	2	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
	156015807	178297	None	0	Human	Binding	pKd	=	9.3	9.3	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178297	None	0	Human	Binding	pKd	=	9.3	9.3	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178297	None	0	Human	Binding	pKd	=	9.3	9.3	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162677523	183672	None	0	Human	Binding	pKd	=	9.2	9.2	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4756833	183672	None	0	Human	Binding	pKd	=	9.2	9.2	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4802932	183672	None	0	Human	Binding	pKd	=	9.2	9.2	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	10387775	78490	None	0	Rat	Binding	pKd	=	9.2	9.2	-3	2	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
	CHEMBL2111842	78490	None	0	Rat	Binding	pKd	=	9.2	9.2	-3	2	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
	162649253	183643	None	0	Human	Binding	pKd	=	9.2	9.2	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4748004	183643	None	0	Human	Binding	pKd	=	9.2	9.2	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4802611	183643	None	0	Human	Binding	pKd	=	9.2	9.2	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	156015900	178319	None	0	Human	Binding	pKd	=	9.2	9.2	5	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4643273	178319	None	0	Human	Binding	pKd	=	9.2	9.2	5	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651104	178319	None	0	Human	Binding	pKd	=	9.2	9.2	5	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	156015900	178319	None	0	Human	Binding	pKd	=	9.2	9.2	5	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4643273	178319	None	0	Human	Binding	pKd	=	9.2	9.2	5	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651104	178319	None	0	Human	Binding	pKd	=	9.2	9.2	5	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	122203596	155804	None	0	Human	Binding	pKd	=	9.2	9.2	1	5	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pKd	=	9.2	9.2	1	5	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pKd	=	9.2	9.2	1	5	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	156015807	178297	None	0	Human	Binding	pKd	=	9.1	9.1	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178297	None	0	Human	Binding	pKd	=	9.1	9.1	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178297	None	0	Human	Binding	pKd	=	9.1	9.1	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	122203596	155804	None	0	Human	Binding	pKd	=	9.1	9.1	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pKd	=	9.1	9.1	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pKd	=	9.1	9.1	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	122203596	155804	None	0	Human	Binding	pKd	=	9.1	9.1	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pKd	=	9.1	9.1	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pKd	=	9.1	9.1	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	4120	5932	None	6	Rat	Binding	pKd	=	9.1	9.1	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	71183	5932	None	6	Rat	Binding	pKd	=	9.1	9.1	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL107979	5932	None	6	Rat	Binding	pKd	=	9.1	9.1	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL293927	5932	None	6	Rat	Binding	pKd	=	9.1	9.1	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL3140030	5932	None	6	Rat	Binding	pKd	=	9.1	9.1	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL376897	5932	None	6	Rat	Binding	pKd	=	9.1	9.1	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	DB11315	5932	None	6	Rat	Binding	pKd	=	9.1	9.1	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	156015807	178297	None	0	Human	Binding	pKd	=	9.1	9.1	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178297	None	0	Human	Binding	pKd	=	9.1	9.1	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178297	None	0	Human	Binding	pKd	=	9.1	9.1	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	137630050	161038	None	0	Human	Binding	pKd	=	9.0	9.0	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pKd	=	9.0	9.0	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pKd	=	9.0	9.0	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pKd	=	9.0	9.0	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	162677523	183672	None	0	Human	Binding	pKd	=	8.9	8.9	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4756833	183672	None	0	Human	Binding	pKd	=	8.9	8.9	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4802932	183672	None	0	Human	Binding	pKd	=	8.9	8.9	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	156014820	178303	None	0	Human	Binding	pKd	=	8.9	8.9	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4646116	178303	None	0	Human	Binding	pKd	=	8.9	8.9	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4650998	178303	None	0	Human	Binding	pKd	=	8.9	8.9	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	156015978	178321	None	0	Human	Binding	pKd	=	8.9	8.9	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178321	None	0	Human	Binding	pKd	=	8.9	8.9	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178321	None	0	Human	Binding	pKd	=	8.9	8.9	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	14753629	13666	None	0	Rat	Binding	pKd	=	8.8	8.8	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL1194660	13666	None	0	Rat	Binding	pKd	=	8.8	8.8	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL553066	13666	None	0	Rat	Binding	pKd	=	8.8	8.8	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	10101246	9544	None	0	Human	Binding	pKd	=	8.8	8.8	-81	2	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL112297	9544	None	0	Human	Binding	pKd	=	8.8	8.8	-81	2	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	162654942	183669	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4754371	183669	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802913	183669	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	162649253	183643	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4748004	183643	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4802611	183643	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	156016041	178245	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178245	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178245	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162645430	183625	None	0	Human	Binding	pKd	=	8.7	8.7	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4744233	183625	None	0	Human	Binding	pKd	=	8.7	8.7	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802409	183625	None	0	Human	Binding	pKd	=	8.7	8.7	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	324	1923	None	15	Rat	Binding	pKd	=	8	8.0	-1	9	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
	6436265	1923	None	15	Rat	Binding	pKd	=	8	8.0	-1	9	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
	CHEMBL277642	1923	None	15	Rat	Binding	pKd	=	8	8.0	-1	9	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
	14753632	13506	None	0	Rat	Binding	pKd	=	8	8.0	-2	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL1193564	13506	None	0	Rat	Binding	pKd	=	8	8.0	-2	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL544993	13506	None	0	Rat	Binding	pKd	=	8	8.0	-2	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	14753634	13725	None	0	Rat	Binding	pKd	=	8	8.0	-5	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL1195059	13725	None	0	Rat	Binding	pKd	=	8	8.0	-5	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL553783	13725	None	0	Rat	Binding	pKd	=	8	8.0	-5	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	156015153	178305	None	0	Human	Binding	pKd	=	8.0	8.0	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178305	None	0	Human	Binding	pKd	=	8.0	8.0	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178305	None	0	Human	Binding	pKd	=	8.0	8.0	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	10125445	76026	None	0	Human	Binding	pKd	=	7	7.0	-25	5	Activity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbacholActivity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbachol	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
	CHEMBL205654	76026	None	0	Human	Binding	pKd	=	7	7.0	-25	5	Activity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbacholActivity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbachol	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
	71716224	86954	None	0	Guinea pig	Binding	pKd	=	6.0	6.0	-1	3	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323444	86954	None	0	Guinea pig	Binding	pKd	=	6.0	6.0	-1	3	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	14753624	13734	None	0	Rat	Binding	pKd	=	8.0	8.0	-4	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL1195123	13734	None	0	Rat	Binding	pKd	=	8.0	8.0	-4	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL553894	13734	None	0	Rat	Binding	pKd	=	8.0	8.0	-4	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	156016041	178245	None	0	Human	Binding	pKd	=	7.9	7.9	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178245	None	0	Human	Binding	pKd	=	7.9	7.9	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178245	None	0	Human	Binding	pKd	=	7.9	7.9	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	156016041	178245	None	0	Human	Binding	pKd	=	7.9	7.9	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178245	None	0	Human	Binding	pKd	=	7.9	7.9	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178245	None	0	Human	Binding	pKd	=	7.9	7.9	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	15038486	85766	None	0	Rat	Binding	pKd	=	5.9	5.9	3	3	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80325-X
	CHEMBL22923	85766	None	0	Rat	Binding	pKd	=	5.9	5.9	3	3	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80325-X
	15038486	85766	None	0	Rat	Binding	pKd	=	5.9	5.9	3	3	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
	CHEMBL22923	85766	None	0	Rat	Binding	pKd	=	5.9	5.9	3	3	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
	71718669	86956	None	0	Guinea pig	Binding	pKd	=	5.9	5.9	2	3	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323446	86956	None	0	Guinea pig	Binding	pKd	=	5.9	5.9	2	3	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	44457850	98956	None	0	Rat	Binding	pKd	=	7.8	7.8	-1	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL279712	98956	None	0	Rat	Binding	pKd	=	7.8	7.8	-1	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	167962	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	167962	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	76315655	106203	None	0	Guinea pig	Binding	pKd	=	5.8	5.8	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	76315655	106203	None	0	Guinea pig	Binding	pKd	=	5.8	5.8	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL2261153	106203	None	0	Guinea pig	Binding	pKd	=	5.8	5.8	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL2261153	106203	None	0	Guinea pig	Binding	pKd	=	5.8	5.8	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL3138747	106203	None	0	Guinea pig	Binding	pKd	=	5.8	5.8	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL3138747	106203	None	0	Guinea pig	Binding	pKd	=	5.8	5.8	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	11957991	106444	None	0	Guinea pig	Binding	pKd	=	5.7	5.7	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	11957991	106444	None	0	Guinea pig	Binding	pKd	=	5.7	5.7	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL2261155	106444	None	0	Guinea pig	Binding	pKd	=	5.7	5.7	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL2261155	106444	None	0	Guinea pig	Binding	pKd	=	5.7	5.7	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL3139843	106444	None	0	Guinea pig	Binding	pKd	=	5.7	5.7	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL3139843	106444	None	0	Guinea pig	Binding	pKd	=	5.7	5.7	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	167962	4067	None	4	Human	Binding	pKd	=	6.7	6.7	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4067	None	4	Human	Binding	pKd	=	6.7	6.7	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4067	None	4	Human	Binding	pKd	=	6.7	6.7	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	162654942	183669	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4754371	183669	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802913	183669	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	156015153	178305	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178305	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178305	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	156015978	178321	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178321	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178321	None	0	Human	Binding	pKd	=	8.7	8.7	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	44457838	161879	None	0	Rat	Binding	pKd	=	8.7	8.7	2	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL415038	161879	None	0	Rat	Binding	pKd	=	8.7	8.7	2	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	156014820	178303	None	0	Human	Binding	pKd	=	8.6	8.6	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4646116	178303	None	0	Human	Binding	pKd	=	8.6	8.6	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4650998	178303	None	0	Human	Binding	pKd	=	8.6	8.6	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	162677513	183742	None	0	Human	Binding	pKd	=	8.6	8.6	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4789147	183742	None	0	Human	Binding	pKd	=	8.6	8.6	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4803695	183742	None	0	Human	Binding	pKd	=	8.6	8.6	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	156015153	178305	None	0	Human	Binding	pKd	=	8.6	8.6	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178305	None	0	Human	Binding	pKd	=	8.6	8.6	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178305	None	0	Human	Binding	pKd	=	8.6	8.6	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	174174	523	None	49	Rat	Binding	pKd	=	8.6	8.6	-4	14	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
	260	523	None	49	Rat	Binding	pKd	=	8.6	8.6	-4	14	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
	320	523	None	49	Rat	Binding	pKd	=	8.6	8.6	-4	14	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
	CHEMBL517712	523	None	49	Rat	Binding	pKd	=	8.6	8.6	-4	14	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
	DB00572	523	None	49	Rat	Binding	pKd	=	8.6	8.6	-4	14	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
	5861	11283	None	11	Rat	Binding	pKd	=	8.6	8.6	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL1179176	11283	None	11	Rat	Binding	pKd	=	8.6	8.6	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL63452	11283	None	11	Rat	Binding	pKd	=	8.6	8.6	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	156015978	178321	None	0	Human	Binding	pKd	=	8.5	8.5	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178321	None	0	Human	Binding	pKd	=	8.5	8.5	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178321	None	0	Human	Binding	pKd	=	8.5	8.5	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	44457835	83384	None	0	Rat	Binding	pKd	=	7.7	7.7	-11	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCCC1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL21942	83384	None	0	Rat	Binding	pKd	=	7.7	7.7	-11	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCCC1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	44457839	83992	None	0	Rat	Binding	pKd	=	7.7	7.7	-4	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.2	CN1CCCCC1C/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL22071	83992	None	0	Rat	Binding	pKd	=	7.7	7.7	-4	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.2	CN1CCCCC1C/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	3636	11145	None	5	Rat	Binding	pKd	=	6.7	6.7	1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL1178342	11145	None	5	Rat	Binding	pKd	=	6.7	6.7	1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL21823	11145	None	5	Rat	Binding	pKd	=	6.7	6.7	1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	14753627	13704	None	0	Rat	Binding	pKd	=	7.6	7.6	-5	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL1194941	13704	None	0	Rat	Binding	pKd	=	7.6	7.6	-5	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL553562	13704	None	0	Rat	Binding	pKd	=	7.6	7.6	-5	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	44373048	52528	None	0	Rat	Binding	pKd	=	6.6	6.6	2	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	433	6	0	5	5.0	CC(=O)OC[C@H]1C[C@H]2CCCC[C@@H]2[C@@H](/C=C/[C@H]2CCC[C@H](C)N2C)[C@H]1[C@H](C)OC(C)=O	10.1016/0960-894X(94)00459-S
	CHEMBL159189	52528	None	0	Rat	Binding	pKd	=	6.6	6.6	2	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	433	6	0	5	5.0	CC(=O)OC[C@H]1C[C@H]2CCCC[C@@H]2[C@@H](/C=C/[C@H]2CCC[C@H](C)N2C)[C@H]1[C@H](C)OC(C)=O	10.1016/0960-894X(94)00459-S
	44457833	94785	None	0	Rat	Binding	pKd	=	7.6	7.6	-7	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	307	2	0	2	4.3	CN1CCCCC1/C=C/C1c2ccccc2OC2C=CC=CC21	10.1016/S0960-894X(00)80325-X
	CHEMBL25334	94785	None	0	Rat	Binding	pKd	=	7.6	7.6	-7	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	307	2	0	2	4.3	CN1CCCCC1/C=C/C1c2ccccc2OC2C=CC=CC21	10.1016/S0960-894X(00)80325-X
	167962	4067	None	4	Human	Binding	pKd	=	6.6	6.6	-	1	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4067	None	4	Human	Binding	pKd	=	6.6	6.6	-	1	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4067	None	4	Human	Binding	pKd	=	6.6	6.6	-	1	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	76312112	106438	None	0	Guinea pig	Binding	pKd	=	6.6	6.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	76312112	106438	None	0	Guinea pig	Binding	pKd	=	6.6	6.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL2261148	106438	None	0	Guinea pig	Binding	pKd	=	6.6	6.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL2261148	106438	None	0	Guinea pig	Binding	pKd	=	6.6	6.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL3139732	106438	None	0	Guinea pig	Binding	pKd	=	6.6	6.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL3139732	106438	None	0	Guinea pig	Binding	pKd	=	6.6	6.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	76315655	106333	None	0	Guinea pig	Binding	pKd	=	7.6	7.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	76315655	106333	None	0	Guinea pig	Binding	pKd	=	7.6	7.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL2261152	106333	None	0	Guinea pig	Binding	pKd	=	7.6	7.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL2261152	106333	None	0	Guinea pig	Binding	pKd	=	7.6	7.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL3139166	106333	None	0	Guinea pig	Binding	pKd	=	7.6	7.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL3139166	106333	None	0	Guinea pig	Binding	pKd	=	7.6	7.6	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	76312110	106435	None	0	Guinea pig	Binding	pKd	=	7.5	7.5	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	76312110	106435	None	0	Guinea pig	Binding	pKd	=	7.5	7.5	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL2261144	106435	None	0	Guinea pig	Binding	pKd	=	7.5	7.5	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL2261144	106435	None	0	Guinea pig	Binding	pKd	=	7.5	7.5	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL3139691	106435	None	0	Guinea pig	Binding	pKd	=	7.5	7.5	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL3139691	106435	None	0	Guinea pig	Binding	pKd	=	7.5	7.5	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	10365181	18555	None	0	Rat	Binding	pKd	=	7.5	7.5	-38	3	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
	CHEMBL127587	18555	None	0	Rat	Binding	pKd	=	7.5	7.5	-38	3	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
	44373347	119563	None	0	Rat	Binding	pKd	=	6.5	6.5	1	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	349	4	2	3	3.8	C[C@H](O)[C@H]1[C@@H](CO)C[C@H]2CCCC[C@@H]2[C@H]1/C=C/[C@H]1CCC[C@H](C)N1C	10.1016/0960-894X(94)00459-S
	CHEMBL346049	119563	None	0	Rat	Binding	pKd	=	6.5	6.5	1	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	349	4	2	3	3.8	C[C@H](O)[C@H]1[C@@H](CO)C[C@H]2CCCC[C@@H]2[C@H]1/C=C/[C@H]1CCC[C@H](C)N1C	10.1016/0960-894X(94)00459-S
	137628879	160970	None	0	Human	Binding	pKd	=	8.5	8.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4068393	160970	None	0	Human	Binding	pKd	=	8.5	8.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4079233	160970	None	0	Human	Binding	pKd	=	8.5	8.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4115977	160970	None	0	Human	Binding	pKd	=	8.5	8.5	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	44457825	163191	None	0	Rat	Binding	pKd	=	8.5	8.5	-1	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCCC1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL418189	163191	None	0	Rat	Binding	pKd	=	8.5	8.5	-1	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCCC1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	324	1923	None	15	Rat	Binding	pKd	=	8.5	8.5	-1	9	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	6436265	1923	None	15	Rat	Binding	pKd	=	8.5	8.5	-1	9	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	CHEMBL277642	1923	None	15	Rat	Binding	pKd	=	8.5	8.5	-1	9	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	11968014	12756	None	5	Rat	Binding	pKd	=	8.5	8.5	-3	9	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm00170a010
	119680147	12756	None	5	Rat	Binding	pKd	=	8.5	8.5	-3	9	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm00170a010
	CHEMBL1187846	12756	None	5	Rat	Binding	pKd	=	8.5	8.5	-3	9	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm00170a010
	DB00747	12756	None	5	Rat	Binding	pKd	=	8.5	8.5	-3	9	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm00170a010
	156015978	178321	None	0	Human	Binding	pKd	=	8.5	8.5	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178321	None	0	Human	Binding	pKd	=	8.5	8.5	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178321	None	0	Human	Binding	pKd	=	8.5	8.5	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	44457832	85621	None	0	Rat	Binding	pKd	=	8.5	8.5	-2	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL22829	85621	None	0	Rat	Binding	pKd	=	8.5	8.5	-2	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	162645430	183625	None	0	Human	Binding	pKd	=	8.4	8.4	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4744233	183625	None	0	Human	Binding	pKd	=	8.4	8.4	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802409	183625	None	0	Human	Binding	pKd	=	8.4	8.4	-1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	162645520	183626	None	0	Human	Binding	pKd	=	8.4	8.4	-10	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4742721	183626	None	0	Human	Binding	pKd	=	8.4	8.4	-10	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802414	183626	None	0	Human	Binding	pKd	=	8.4	8.4	-10	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	44457828	161878	None	0	Rat	Binding	pKd	=	7.5	7.5	-1	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL415037	161878	None	0	Rat	Binding	pKd	=	7.5	7.5	-1	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	44373093	54101	None	0	Rat	Binding	pKd	=	6.5	6.5	-2	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	331	2	0	2	4.9	C[C@@H]1OC[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]21	10.1016/0960-894X(94)00459-S
	CHEMBL160666	54101	None	0	Rat	Binding	pKd	=	6.5	6.5	-2	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	331	2	0	2	4.9	C[C@@H]1OC[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]21	10.1016/0960-894X(94)00459-S
	57664406	2396	None	50	Human	Binding	pKd	=	5.5	5.5	-1	2	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	6938	2396	None	50	Human	Binding	pKd	=	5.5	5.5	-1	2	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089376	2396	None	50	Human	Binding	pKd	=	5.5	5.5	-1	2	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	156016041	178245	None	0	Human	Binding	pKd	=	8.4	8.4	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178245	None	0	Human	Binding	pKd	=	8.4	8.4	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178245	None	0	Human	Binding	pKd	=	8.4	8.4	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162677513	183742	None	0	Human	Binding	pKd	=	8.4	8.4	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4789147	183742	None	0	Human	Binding	pKd	=	8.4	8.4	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4803695	183742	None	0	Human	Binding	pKd	=	8.4	8.4	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	156016041	178245	None	0	Human	Binding	pKd	=	8.4	8.4	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178245	None	0	Human	Binding	pKd	=	8.4	8.4	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178245	None	0	Human	Binding	pKd	=	8.4	8.4	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162645520	183626	None	0	Human	Binding	pKd	=	8.4	8.4	-10	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4742721	183626	None	0	Human	Binding	pKd	=	8.4	8.4	-10	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802414	183626	None	0	Human	Binding	pKd	=	8.4	8.4	-10	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	137628879	160970	None	0	Human	Binding	pKd	=	8.3	8.3	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4068393	160970	None	0	Human	Binding	pKd	=	8.3	8.3	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4079233	160970	None	0	Human	Binding	pKd	=	8.3	8.3	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4115977	160970	None	0	Human	Binding	pKd	=	8.3	8.3	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	324	1923	None	15	Rat	Binding	pKd	=	8.3	8.3	-1	9	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	6436265	1923	None	15	Rat	Binding	pKd	=	8.3	8.3	-1	9	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	CHEMBL277642	1923	None	15	Rat	Binding	pKd	=	8.3	8.3	-1	9	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	156015807	178297	None	0	Human	Binding	pKd	=	8.3	8.3	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178297	None	0	Human	Binding	pKd	=	8.3	8.3	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178297	None	0	Human	Binding	pKd	=	8.3	8.3	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	10055202	11531	None	1	Human	Binding	pKd	=	6.4	6.4	5	2	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm100293f
	CHEMBL11805	11531	None	1	Human	Binding	pKd	=	6.4	6.4	5	2	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm100293f
	10365181	18555	None	0	Rat	Binding	pKd	=	7.4	7.4	-38	3	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
	CHEMBL127587	18555	None	0	Rat	Binding	pKd	=	7.4	7.4	-38	3	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
	15038486	85766	None	0	Human	Binding	pKd	=	5.4	5.4	-3	3	Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
	CHEMBL22923	85766	None	0	Human	Binding	pKd	=	5.4	5.4	-3	3	Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
	167962	4067	None	4	Human	Binding	pKd	=	6.3	6.3	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4067	None	4	Human	Binding	pKd	=	6.3	6.3	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4067	None	4	Human	Binding	pKd	=	6.3	6.3	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	44373067	51903	None	0	Rat	Binding	pKd	=	6.3	6.3	5	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	431	3	0	4	5.8	C[C@@H]1O[C@H](OC(=O)C(C)(C)C)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
	CHEMBL158589	51903	None	0	Rat	Binding	pKd	=	6.3	6.3	5	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	431	3	0	4	5.8	C[C@@H]1O[C@H](OC(=O)C(C)(C)C)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
	9979830	13045	None	0	Guinea pig	Binding	pKd	=	8.3	8.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
	9979830	13045	None	0	Guinea pig	Binding	pKd	=	8.3	8.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL1190002	13045	None	0	Guinea pig	Binding	pKd	=	8.3	8.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL1190002	13045	None	0	Guinea pig	Binding	pKd	=	8.3	8.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL539879	13045	None	0	Guinea pig	Binding	pKd	=	8.3	8.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL539879	13045	None	0	Guinea pig	Binding	pKd	=	8.3	8.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
	156015807	178297	None	0	Human	Binding	pKd	=	8.3	8.3	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178297	None	0	Human	Binding	pKd	=	8.3	8.3	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178297	None	0	Human	Binding	pKd	=	8.3	8.3	3	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	156015978	178321	None	0	Human	Binding	pKd	=	8.3	8.3	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178321	None	0	Human	Binding	pKd	=	8.3	8.3	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178321	None	0	Human	Binding	pKd	=	8.3	8.3	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	11957991	106439	None	0	Guinea pig	Binding	pKd	=	6.3	6.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	11957991	106439	None	0	Guinea pig	Binding	pKd	=	6.3	6.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL2261154	106439	None	0	Guinea pig	Binding	pKd	=	6.3	6.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL2261154	106439	None	0	Guinea pig	Binding	pKd	=	6.3	6.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL3139733	106439	None	0	Guinea pig	Binding	pKd	=	6.3	6.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL3139733	106439	None	0	Guinea pig	Binding	pKd	=	6.3	6.3	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	76319430	106441	None	0	Guinea pig	Binding	pKd	=	7.2	7.2	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL2262220	106441	None	0	Guinea pig	Binding	pKd	=	7.2	7.2	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL3139826	106441	None	0	Guinea pig	Binding	pKd	=	7.2	7.2	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	76330179	106442	None	0	Guinea pig	Binding	pKd	=	7.2	7.2	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL2261145	106442	None	0	Guinea pig	Binding	pKd	=	7.2	7.2	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL3139827	106442	None	0	Guinea pig	Binding	pKd	=	7.2	7.2	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	14753637	13487	None	0	Rat	Binding	pKd	=	8.2	8.2	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL1193366	13487	None	0	Rat	Binding	pKd	=	8.2	8.2	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL544759	13487	None	0	Rat	Binding	pKd	=	8.2	8.2	-1	3	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	324	1923	None	15	Rat	Binding	pKd	=	8.2	8.2	-1	9	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	6436265	1923	None	15	Rat	Binding	pKd	=	8.2	8.2	-1	9	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	CHEMBL277642	1923	None	15	Rat	Binding	pKd	=	8.2	8.2	-1	9	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	71720488	86951	None	0	Guinea pig	Binding	pKd	=	6.2	6.2	2	3	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323441	86951	None	0	Guinea pig	Binding	pKd	=	6.2	6.2	2	3	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	44457844	85813	None	0	Rat	Binding	pKd	=	6.2	6.2	1	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	301	2	0	1	5.5	CN1CCCCC1/C=C/c1c2ccccc2cc2ccccc12	10.1016/S0960-894X(00)80325-X
	CHEMBL22962	85813	None	0	Rat	Binding	pKd	=	6.2	6.2	1	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	301	2	0	1	5.5	CN1CCCCC1/C=C/c1c2ccccc2cc2ccccc12	10.1016/S0960-894X(00)80325-X
	44457834	84715	None	0	Rat	Binding	pKd	=	8.1	8.1	-1	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.3	CN1CCCCC1CCC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL22278	84715	None	0	Rat	Binding	pKd	=	8.1	8.1	-1	2	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.3	CN1CCCCC1CCC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	137628879	160970	None	0	Human	Binding	pKd	=	8.1	8.1	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4068393	160970	None	0	Human	Binding	pKd	=	8.1	8.1	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4079233	160970	None	0	Human	Binding	pKd	=	8.1	8.1	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4115977	160970	None	0	Human	Binding	pKd	=	8.1	8.1	1	5	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	156015153	178305	None	0	Human	Binding	pKd	=	8.1	8.1	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178305	None	0	Human	Binding	pKd	=	8.1	8.1	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178305	None	0	Human	Binding	pKd	=	8.1	8.1	1	5	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	76308444	106436	None	0	Guinea pig	Binding	pKd	=	6.1	6.1	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	76308444	106436	None	0	Guinea pig	Binding	pKd	=	6.1	6.1	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL2261149	106436	None	0	Guinea pig	Binding	pKd	=	6.1	6.1	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL2261149	106436	None	0	Guinea pig	Binding	pKd	=	6.1	6.1	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL3139712	106436	None	0	Guinea pig	Binding	pKd	=	6.1	6.1	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL3139712	106436	None	0	Guinea pig	Binding	pKd	=	6.1	6.1	-	1	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	71716836	86952	None	0	Guinea pig	Binding	pKd	=	6.1	6.1	4	3	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323442	86952	None	0	Guinea pig	Binding	pKd	=	6.1	6.1	4	3	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	10318189	54229	None	0	Rat	Binding	pKd	=	7.1	7.1	9	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	389	3	0	4	4.8	CC(=O)O[C@H]1O[C@@H](C)[C@@H]2[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]3CCCC[C@@H]3C[C@H]12	10.1016/0960-894X(94)00459-S
	CHEMBL160755	54229	None	0	Rat	Binding	pKd	=	7.1	7.1	9	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	389	3	0	4	4.8	CC(=O)O[C@H]1O[C@@H](C)[C@@H]2[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]3CCCC[C@@H]3C[C@H]12	10.1016/0960-894X(94)00459-S
	324	1923	None	15	Rat	Binding	pKd	=	8.0	8.0	-1	9	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
	6436265	1923	None	15	Rat	Binding	pKd	=	8.0	8.0	-1	9	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
	CHEMBL277642	1923	None	15	Rat	Binding	pKd	=	8.0	8.0	-1	9	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
	44373049	52564	None	0	Rat	Binding	pKd	=	7.0	7.0	4	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	347	2	1	3	4.2	C[C@@H]1O[C@H](O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
	CHEMBL159237	52564	None	0	Rat	Binding	pKd	=	7.0	7.0	4	2	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	347	2	1	3	4.2	C[C@@H]1O[C@H](O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
	9916852	204917	None	0	Human	Binding	pKi	=	11	11.0	-	1	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
	CHEMBL76164	204917	None	0	Human	Binding	pKi	=	11	11.0	-	1	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
	9916852	204917	None	0	Human	Binding	pKi	=	11	11.0	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL76164	204917	None	0	Human	Binding	pKi	=	11	11.0	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	367	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	5487427	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	8592	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	DB01409	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	367	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	5487427	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	8592	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	DB01409	3822	None	12	Human	Binding	pKi	=	10.7	10.7	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	59291417	112821	None	0	Rat	Binding	pKi	=	10.6	10.6	-1	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298595	112821	None	0	Rat	Binding	pKi	=	10.6	10.6	-1	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307168	112821	None	0	Rat	Binding	pKi	=	10.6	10.6	-1	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	688566	195881	None	24	Rat	Binding	pKi	=	10.5	10.5	-1	3	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00059a009
	CHEMBL558910	195881	None	24	Rat	Binding	pKi	=	10.5	10.5	-1	3	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00059a009
	71452756	79539	None	0	Human	Binding	pKi	=	10.5	10.5	2	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	CHEMBL2114068	79539	None	0	Human	Binding	pKi	=	10.5	10.5	2	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	44378845	57155	None	0	Human	Binding	pKi	=	10.5	10.5	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H]1CN(C2CCCCC2)CCN1[C@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL164705	57155	None	0	Human	Binding	pKi	=	10.5	10.5	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H]1CN(C2CCCCC2)CCN1[C@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(02)00023-9
	44378762	119926	None	0	Human	Binding	pKi	=	10.5	10.5	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCCCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	CHEMBL349497	119926	None	0	Human	Binding	pKi	=	10.5	10.5	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCCCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	44324892	111563	None	0	Human	Binding	pKi	=	10.5	10.5	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328094	111563	None	0	Human	Binding	pKi	=	10.5	10.5	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	688566	195881	None	24	Rat	Binding	pKi	=	10.5	10.5	-1	3	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00114a005
	CHEMBL558910	195881	None	24	Rat	Binding	pKi	=	10.5	10.5	-1	3	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00114a005
	688566	195881	None	24	Rat	Binding	pKi	=	10.5	10.5	-1	3	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/S0960-894X(97)00143-1
	CHEMBL558910	195881	None	24	Rat	Binding	pKi	=	10.5	10.5	-1	3	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/S0960-894X(97)00143-1
	44325018	206872	None	0	Human	Binding	pKi	=	10.5	10.5	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	638	8	0	9	4.8	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL90700	206872	None	0	Human	Binding	pKi	=	10.5	10.5	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	638	8	0	9	4.8	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	44378811	120099	None	0	Human	Binding	pKi	=	10.4	10.4	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL350956	120099	None	0	Human	Binding	pKi	=	10.4	10.4	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	23056	112	None	29	Human	Binding	pKi	=	10.4	10.4	-1	8	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
	318	112	None	29	Human	Binding	pKi	=	10.4	10.4	-1	8	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
	3260	112	None	29	Human	Binding	pKi	=	10.4	10.4	-1	8	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL12980	112	None	29	Human	Binding	pKi	=	10.4	10.4	-1	8	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
	25005841	112818	None	0	Rat	Binding	pKi	=	10.3	10.3	-1	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298599	112818	None	0	Rat	Binding	pKi	=	10.3	10.3	-1	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307130	112818	None	0	Rat	Binding	pKi	=	10.3	10.3	-1	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	16065402	67925	None	0	Human	Binding	pKi	=	10.3	10.3	1	2	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	428	9	1	3	4.8	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2ccccc2)C1	10.1021/jm200884j
	CHEMBL1910848	67925	None	0	Human	Binding	pKi	=	10.3	10.3	1	2	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	428	9	1	3	4.8	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2ccccc2)C1	10.1021/jm200884j
	71454563	79654	None	0	Human	Binding	pKi	=	10.2	10.2	5	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	CHEMBL2115128	79654	None	0	Human	Binding	pKi	=	10.2	10.2	5	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	10143956	13909	None	0	Human	Binding	pKi	=	10.2	10.2	1	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL1196359	13909	None	0	Human	Binding	pKi	=	10.2	10.2	1	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL556635	13909	None	0	Human	Binding	pKi	=	10.2	10.2	1	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	367	3822	None	12	Human	Binding	pKi	=	10.2	10.2	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	5487427	3822	None	12	Human	Binding	pKi	=	10.2	10.2	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	8592	3822	None	12	Human	Binding	pKi	=	10.2	10.2	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	10.2	10.2	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	10.2	10.2	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	10.2	10.2	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	DB01409	3822	None	12	Human	Binding	pKi	=	10.2	10.2	-2	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	155566290	176578	None	0	Human	Binding	pKi	=	10.2	10.2	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176578	None	0	Human	Binding	pKi	=	10.2	10.2	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176578	None	0	Human	Binding	pKi	=	10.2	10.2	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	155550632	176527	None	0	Human	Binding	pKi	=	10.2	10.2	19	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4540949	176527	None	0	Human	Binding	pKi	=	10.2	10.2	19	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597071	176527	None	0	Human	Binding	pKi	=	10.2	10.2	19	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	155566290	176578	None	0	Human	Binding	pKi	=	10.2	10.2	25	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176578	None	0	Human	Binding	pKi	=	10.2	10.2	25	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176578	None	0	Human	Binding	pKi	=	10.2	10.2	25	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	23724781	2833	None	19	Human	Binding	pKi	=	10.2	10.2	-6	9	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	316	2833	None	19	Human	Binding	pKi	=	10.2	10.2	-6	9	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	317	2833	None	19	Human	Binding	pKi	=	10.2	10.2	-6	9	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	71183	2833	None	19	Human	Binding	pKi	=	10.2	10.2	-6	9	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	10.2	10.2	-6	9	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	10.2	10.2	-6	9	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	10.2	10.2	-6	9	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	DB00462	2833	None	19	Human	Binding	pKi	=	10.2	10.2	-6	9	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	44343733	13430	None	0	Rat	Binding	pKi	=	10.2	10.2	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	6	0	8	4.8	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
	CHEMBL119294	13430	None	0	Rat	Binding	pKi	=	10.2	10.2	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	6	0	8	4.8	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
	9827782	103551	None	0	Human	Binding	pKi	=	10.2	10.2	41	3	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL308566	103551	None	0	Human	Binding	pKi	=	10.2	10.2	41	3	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00553-9
	15407089	207450	None	0	Human	Binding	pKi	=	10.1	10.1	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	6	0	9	3.8	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL94189	207450	None	0	Human	Binding	pKi	=	10.1	10.1	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	6	0	9	3.8	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	10457079	10028	None	0	Human	Binding	pKi	=	10.1	10.1	-4	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL115078	10028	None	0	Human	Binding	pKi	=	10.1	10.1	-4	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	155566290	176578	None	0	Human	Binding	pKi	=	10.1	10.1	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176578	None	0	Human	Binding	pKi	=	10.1	10.1	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176578	None	0	Human	Binding	pKi	=	10.1	10.1	25	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	164611865	188474	None	0	Human	Binding	pKi	=	10.1	10.1	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4856113	188474	None	0	Human	Binding	pKi	=	10.1	10.1	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028107	188474	None	0	Human	Binding	pKi	=	10.1	10.1	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	155525097	170948	None	0	Human	Binding	pKi	=	10.1	10.1	18	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	712	13	1	10	5.5	CN1CC=C(c2nsnc2OCCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4455570	170948	None	0	Human	Binding	pKi	=	10.1	10.1	18	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	712	13	1	10	5.5	CN1CC=C(c2nsnc2OCCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	155567380	176406	None	0	Human	Binding	pKi	=	10.1	10.1	20	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4589047	176406	None	0	Human	Binding	pKi	=	10.1	10.1	20	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596064	176406	None	0	Human	Binding	pKi	=	10.1	10.1	20	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	155521894	176423	None	0	Human	Binding	pKi	=	10.1	10.1	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451383	176423	None	0	Human	Binding	pKi	=	10.1	10.1	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596183	176423	None	0	Human	Binding	pKi	=	10.1	10.1	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	155550436	176499	None	0	Human	Binding	pKi	=	10.1	10.1	14	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4569639	176499	None	0	Human	Binding	pKi	=	10.1	10.1	14	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596780	176499	None	0	Human	Binding	pKi	=	10.1	10.1	14	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	11434515	261	None	6	Human	Binding	pKi	=	10.1	10.1	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	11519741	261	None	6	Human	Binding	pKi	=	10.1	10.1	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	4484	261	None	6	Human	Binding	pKi	=	10.1	10.1	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	7449	261	None	6	Human	Binding	pKi	=	10.1	10.1	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	CHEMBL1194325	261	None	6	Human	Binding	pKi	=	10.1	10.1	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	DB08897	261	None	6	Human	Binding	pKi	=	10.1	10.1	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	11852298	14024	None	0	Human	Binding	pKi	=	10.1	10.1	-1	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1197251	14024	None	0	Human	Binding	pKi	=	10.1	10.1	-1	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL564057	14024	None	0	Human	Binding	pKi	=	10.1	10.1	-1	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	44378875	57187	None	0	Human	Binding	pKi	=	10	10.0	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	7	0	8	4.6	COc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL164935	57187	None	0	Human	Binding	pKi	=	10	10.0	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	7	0	8	4.6	COc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	44379051	58086	None	0	Human	Binding	pKi	=	10	10.0	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	667	8	0	8	6.4	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Oc3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL167396	58086	None	0	Human	Binding	pKi	=	10	10.0	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	667	8	0	8	6.4	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Oc3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	10461523	120247	None	0	Human	Binding	pKi	=	10	10.0	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	6	0	9	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3cccc4c3OCO4)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL352291	120247	None	0	Human	Binding	pKi	=	10	10.0	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	6	0	9	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3cccc4c3OCO4)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	44379021	120258	None	0	Human	Binding	pKi	=	10	10.0	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	609	6	0	7	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL352380	120258	None	0	Human	Binding	pKi	=	10	10.0	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	609	6	0	7	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	367	3822	None	12	Human	Binding	pKi	=	10	10.0	-2	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	5487427	3822	None	12	Human	Binding	pKi	=	10	10.0	-2	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	8592	3822	None	12	Human	Binding	pKi	=	10	10.0	-2	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	10	10.0	-2	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	10	10.0	-2	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	10	10.0	-2	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	DB01409	3822	None	12	Human	Binding	pKi	=	10	10.0	-2	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	44274333	11144	None	0	Rat	Binding	pKi	=	10	10.0	-5	2	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
	CHEMBL1178341	11144	None	0	Rat	Binding	pKi	=	10	10.0	-5	2	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
	CHEMBL21812	11144	None	0	Rat	Binding	pKi	=	10	10.0	-5	2	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
	11431874	74278	None	0	Human	Binding	pKi	=	10	10.0	1	3	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
	CHEMBL2023762	74278	None	0	Human	Binding	pKi	=	10	10.0	1	3	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
	CHEMBL2023764	74278	None	0	Human	Binding	pKi	=	10	10.0	1	3	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
	155566290	176578	None	0	Human	Binding	pKi	=	10	10.0	25	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4582879	176578	None	0	Human	Binding	pKi	=	10	10.0	25	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4597498	176578	None	0	Human	Binding	pKi	=	10	10.0	25	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164622681	188560	None	0	Human	Binding	pKi	=	10.0	10.0	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4864727	188560	None	0	Human	Binding	pKi	=	10.0	10.0	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028712	188560	None	0	Human	Binding	pKi	=	10.0	10.0	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164616463	188512	None	0	Human	Binding	pKi	=	10.0	10.0	14	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
	CHEMBL4859378	188512	None	0	Human	Binding	pKi	=	10.0	10.0	14	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
	CHEMBL5028381	188512	None	0	Human	Binding	pKi	=	10.0	10.0	14	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
	137630050	161038	None	0	Human	Binding	pKi	=	10.0	10.0	1	5	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pKi	=	10.0	10.0	1	5	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pKi	=	10.0	10.0	1	5	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pKi	=	10.0	10.0	1	5	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	9827782	103551	None	0	Human	Binding	pKi	=	10.0	10.0	41	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL308566	103551	None	0	Human	Binding	pKi	=	10.0	10.0	41	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	9827782	103551	None	0	Human	Binding	pKi	=	10.0	10.0	41	3	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL308566	103551	None	0	Human	Binding	pKi	=	10.0	10.0	41	3	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	15453419	207459	None	0	Human	Binding	pKi	=	10.0	10.0	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	7	0	8	5.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL94247	207459	None	0	Human	Binding	pKi	=	10.0	10.0	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	7	0	8	5.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	9827782	103551	None	0	Human	Binding	pKi	=	10.0	10.0	41	3	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL308566	103551	None	0	Human	Binding	pKi	=	10.0	10.0	41	3	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
	140844407	176630	None	0	Human	Binding	pKi	=	10.0	10.0	4	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4519930	176630	None	0	Human	Binding	pKi	=	10.0	10.0	4	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597916	176630	None	0	Human	Binding	pKi	=	10.0	10.0	4	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	155539713	176358	None	0	Human	Binding	pKi	=	9.9	9.9	20	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4515788	176358	None	0	Human	Binding	pKi	=	9.9	9.9	20	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595691	176358	None	0	Human	Binding	pKi	=	9.9	9.9	20	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	44431393	88022	None	0	Human	Binding	pKi	=	9.9	9.9	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234440	88022	None	0	Human	Binding	pKi	=	9.9	9.9	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	10.1016/j.bmcl.2006.11.058
	59291241	112813	None	0	Rat	Binding	pKi	=	9.9	9.9	-2	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298596	112813	None	0	Rat	Binding	pKi	=	9.9	9.9	-2	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307116	112813	None	0	Rat	Binding	pKi	=	9.9	9.9	-2	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	9809330	115997	None	0	Human	Binding	pKi	=	9.9	9.9	-1	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
	CHEMBL335542	115997	None	0	Human	Binding	pKi	=	9.9	9.9	-1	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
	15407088	206991	None	0	Human	Binding	pKi	=	9.9	9.9	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	528	6	0	8	3.8	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL91404	206991	None	0	Human	Binding	pKi	=	9.9	9.9	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	528	6	0	8	3.8	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	44292486	181509	None	0	Rat	Binding	pKi	=	9.9	9.9	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	CHEMBL47650	181509	None	0	Rat	Binding	pKi	=	9.9	9.9	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	16065403	67933	None	23	Human	Binding	pKi	=	9.9	9.9	-1	5	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	444	9	2	4	4.5	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1	10.1021/jm200884j
	CHEMBL1910856	67933	None	23	Human	Binding	pKi	=	9.9	9.9	-1	5	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	444	9	2	4	4.5	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1	10.1021/jm200884j
	23724781	2833	None	19	Human	Binding	pKi	=	9.9	9.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	316	2833	None	19	Human	Binding	pKi	=	9.9	9.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	317	2833	None	19	Human	Binding	pKi	=	9.9	9.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	71183	2833	None	19	Human	Binding	pKi	=	9.9	9.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	9.9	9.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	9.9	9.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	9.9	9.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	DB00462	2833	None	19	Human	Binding	pKi	=	9.9	9.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	44610056	123989	None	0	Human	Binding	pKi	=	9.9	9.9	1	5	Antagonist activity at muscarinic M2 receptor (unknown origin)Antagonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL	704	14	5	9	5.5	O=c1ccc2c([C@@H](O)CNCCc3ccc(CCN4CCC(Cn5cnc([C@](O)(c6ccccc6)C6CCCCC6)n5)CC4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2015.10.008
	CHEMBL3629360	123989	None	0	Human	Binding	pKi	=	9.9	9.9	1	5	Antagonist activity at muscarinic M2 receptor (unknown origin)Antagonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL	704	14	5	9	5.5	O=c1ccc2c([C@@H](O)CNCCc3ccc(CCN4CCC(Cn5cnc([C@](O)(c6ccccc6)C6CCCCC6)n5)CC4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2015.10.008
	10274019	204249	None	0	Human	Binding	pKi	=	9.9	9.9	-1	5	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	3	6.0	COc1ccc([S+]([O-])c2ccc(C(C)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL71124	204249	None	0	Human	Binding	pKi	=	9.9	9.9	-1	5	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	3	6.0	COc1ccc([S+]([O-])c2ccc(C(C)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	44378846	57165	None	0	Human	Binding	pKi	=	9.9	9.9	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL164762	57165	None	0	Human	Binding	pKi	=	9.9	9.9	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	164622945	188563	None	0	Human	Binding	pKi	=	9.9	9.9	6	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	CHEMBL4871700	188563	None	0	Human	Binding	pKi	=	9.9	9.9	6	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	CHEMBL5028723	188563	None	0	Human	Binding	pKi	=	9.9	9.9	6	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	155523648	176591	None	0	Human	Binding	pKi	=	9.8	9.8	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4454300	176591	None	0	Human	Binding	pKi	=	9.8	9.8	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597576	176591	None	0	Human	Binding	pKi	=	9.8	9.8	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	15463388	165690	None	0	Human	Binding	pKi	=	9.8	9.8	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL424530	165690	None	0	Human	Binding	pKi	=	9.8	9.8	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	49800047	14481	None	1	Human	Binding	pKi	=	9.8	9.8	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	CHEMBL1201024	14481	None	1	Human	Binding	pKi	=	9.8	9.8	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	CHEMBL1201268	14481	None	1	Human	Binding	pKi	=	9.8	9.8	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	367	3822	None	12	Rat	Binding	pKi	=	9.8	9.8	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	5487427	3822	None	12	Rat	Binding	pKi	=	9.8	9.8	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	8592	3822	None	12	Rat	Binding	pKi	=	9.8	9.8	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	CHEMBL1900528	3822	None	12	Rat	Binding	pKi	=	9.8	9.8	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	CHEMBL3305968	3822	None	12	Rat	Binding	pKi	=	9.8	9.8	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	CHEMBL4650755	3822	None	12	Rat	Binding	pKi	=	9.8	9.8	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	DB01409	3822	None	12	Rat	Binding	pKi	=	9.8	9.8	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	11519069	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	11519070	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	4816	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	7354	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	CHEMBL1187833	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	DB09076	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	164615275	188505	None	0	Human	Binding	pKi	=	9.8	9.8	8	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4861252	188505	None	0	Human	Binding	pKi	=	9.8	9.8	8	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028304	188505	None	0	Human	Binding	pKi	=	9.8	9.8	8	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	367	3822	None	12	Human	Binding	pKi	=	9.8	9.8	-2	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	5487427	3822	None	12	Human	Binding	pKi	=	9.8	9.8	-2	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	8592	3822	None	12	Human	Binding	pKi	=	9.8	9.8	-2	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	9.8	9.8	-2	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	9.8	9.8	-2	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	9.8	9.8	-2	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	DB01409	3822	None	12	Human	Binding	pKi	=	9.8	9.8	-2	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	25195533	78384	None	2	Human	Binding	pKi	=	9.8	9.8	-2	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2103803	78384	None	2	Human	Binding	pKi	=	9.8	9.8	-2	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2110584	78384	None	2	Human	Binding	pKi	=	9.8	9.8	-2	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	9984928	204681	None	0	Human	Binding	pKi	=	9.8	9.8	199	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL73893	204681	None	0	Human	Binding	pKi	=	9.8	9.8	199	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44325048	111555	None	0	Human	Binding	pKi	=	9.8	9.8	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	558	7	0	8	4.1	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328059	111555	None	0	Human	Binding	pKi	=	9.8	9.8	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	558	7	0	8	4.1	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	9984928	204681	None	0	Human	Binding	pKi	=	9.8	9.8	199	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL73893	204681	None	0	Human	Binding	pKi	=	9.8	9.8	199	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44379026	120300	None	0	Human	Binding	pKi	=	9.8	9.8	-	1	Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL352739	120300	None	0	Human	Binding	pKi	=	9.8	9.8	-	1	Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	14537188	136544	None	0	Human	Binding	pKi	=	9.8	9.8	1	5	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1016/j.bmc.2013.01.072
	CHEMBL37372	136544	None	0	Human	Binding	pKi	=	9.8	9.8	1	5	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1016/j.bmc.2013.01.072
	9867847	204256	None	0	Human	Binding	pKi	=	9.8	9.8	1	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	CHEMBL71147	204256	None	0	Human	Binding	pKi	=	9.8	9.8	1	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	9867847	204256	None	0	Human	Binding	pKi	=	9.8	9.8	1	4	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL71147	204256	None	0	Human	Binding	pKi	=	9.8	9.8	1	4	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00457-1
	25195533	78384	None	2	Human	Binding	pKi	=	9.8	9.8	-2	3	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
	CHEMBL2103803	78384	None	2	Human	Binding	pKi	=	9.8	9.8	-2	3	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
	CHEMBL2110584	78384	None	2	Human	Binding	pKi	=	9.8	9.8	-2	3	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
	155556290	176454	None	0	Human	Binding	pKi	=	9.8	9.8	7	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4554682	176454	None	0	Human	Binding	pKi	=	9.8	9.8	7	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596434	176454	None	0	Human	Binding	pKi	=	9.8	9.8	7	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	44337753	108999	None	0	Rat	Binding	pKi	=	9.8	9.8	-	1	Compound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligandCompound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligand	ChEMBL	351	4	1	4	2.9	CN1CC2CC1C[C@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm00115a003
	CHEMBL321214	108999	None	0	Rat	Binding	pKi	=	9.8	9.8	-	1	Compound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligandCompound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligand	ChEMBL	351	4	1	4	2.9	CN1CC2CC1C[C@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm00115a003
	23724781	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	316	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	317	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	71183	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	DB00462	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	164626501	188594	None	0	Human	Binding	pKi	=	9.8	9.8	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4874955	188594	None	0	Human	Binding	pKi	=	9.8	9.8	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028936	188594	None	0	Human	Binding	pKi	=	9.8	9.8	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	23724781	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	316	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	317	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	71183	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	DB00462	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	23724781	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	316	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	317	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	71183	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	DB00462	2833	None	19	Human	Binding	pKi	=	9.8	9.8	-6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	140844416	176604	None	0	Human	Binding	pKi	=	9.7	9.7	12	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4516342	176604	None	0	Human	Binding	pKi	=	9.7	9.7	12	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597717	176604	None	0	Human	Binding	pKi	=	9.7	9.7	12	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	23056	112	None	29	Rat	Binding	pKi	=	9.7	9.7	-5	8	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
	318	112	None	29	Rat	Binding	pKi	=	9.7	9.7	-5	8	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
	3260	112	None	29	Rat	Binding	pKi	=	9.7	9.7	-5	8	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
	CHEMBL12980	112	None	29	Rat	Binding	pKi	=	9.7	9.7	-5	8	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
	156014450	178249	None	0	Human	Binding	pKi	=	9.7	9.7	2	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4636083	178249	None	0	Human	Binding	pKi	=	9.7	9.7	2	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650652	178249	None	0	Human	Binding	pKi	=	9.7	9.7	2	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	164617895	188523	None	0	Human	Binding	pKi	=	9.7	9.7	41	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852868	188523	None	0	Human	Binding	pKi	=	9.7	9.7	41	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028466	188523	None	0	Human	Binding	pKi	=	9.7	9.7	41	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164627113	188600	None	0	Human	Binding	pKi	=	9.7	9.7	13	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4878646	188600	None	0	Human	Binding	pKi	=	9.7	9.7	13	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028981	188600	None	0	Human	Binding	pKi	=	9.7	9.7	13	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164611189	188469	None	0	Human	Binding	pKi	=	9.7	9.7	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4851514	188469	None	0	Human	Binding	pKi	=	9.7	9.7	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028061	188469	None	0	Human	Binding	pKi	=	9.7	9.7	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164614083	188489	None	0	Human	Binding	pKi	=	9.7	9.7	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4855492	188489	None	0	Human	Binding	pKi	=	9.7	9.7	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028231	188489	None	0	Human	Binding	pKi	=	9.7	9.7	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015648	178313	None	0	Human	Binding	pKi	=	9.7	9.7	8	3	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4641328	178313	None	0	Human	Binding	pKi	=	9.7	9.7	8	3	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4651078	178313	None	0	Human	Binding	pKi	=	9.7	9.7	8	3	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL5074599	214317	None	2	Human	Binding	pKi	=	9.7	9.7	-2	2	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL		None	None	None		COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)c2ccc(CNC(C(=O)O[C@H]3CN4CCC3CC4)c3ccccc3)s2)cc1OC	10.1021/acs.jmedchem.1c00204
	9937474	170468	None	0	Human	Binding	pKi	=	9.7	9.7	363	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4448933	170468	None	0	Human	Binding	pKi	=	9.7	9.7	363	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1016/j.ejmech.2021.113159
	9937474	170468	None	0	Human	Binding	pKi	=	9.7	9.7	363	5	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4448933	170468	None	0	Human	Binding	pKi	=	9.7	9.7	363	5	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	44378842	57421	None	0	Human	Binding	pKi	=	9.7	9.7	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	577	8	0	8	3.5	CCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	CHEMBL165375	57421	None	0	Human	Binding	pKi	=	9.7	9.7	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	577	8	0	8	3.5	CCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	44378601	168581	None	0	Human	Binding	pKi	=	9.7	9.7	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	591	9	0	8	3.9	CCCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	CHEMBL435849	168581	None	0	Human	Binding	pKi	=	9.7	9.7	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	591	9	0	8	3.9	CCCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	15407074	57422	None	0	Human	Binding	pKi	=	9.7	9.7	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	589	6	0	7	4.9	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL165377	57422	None	0	Human	Binding	pKi	=	9.7	9.7	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	589	6	0	7	4.9	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	44379050	161506	None	0	Human	Binding	pKi	=	9.7	9.7	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	709	9	0	9	6.0	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3COC(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL412814	161506	None	0	Human	Binding	pKi	=	9.7	9.7	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	709	9	0	9	6.0	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3COC(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	10109130	133013	None	0	Human	Binding	pKi	=	9.7	9.7	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL370232	133013	None	0	Human	Binding	pKi	=	9.7	9.7	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	9894236	60227	None	0	Human	Binding	pKi	=	9.7	9.7	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	568	6	0	8	4.8	Cc1ccsc1C(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL174070	60227	None	0	Human	Binding	pKi	=	9.7	9.7	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	568	6	0	8	4.8	Cc1ccsc1C(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	15392110	105483	None	0	Human	Binding	pKi	=	9.7	9.7	6	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	412	5	0	4	4.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL312085	105483	None	0	Human	Binding	pKi	=	9.7	9.7	6	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	412	5	0	4	4.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	164618444	188527	None	0	Human	Binding	pKi	=	9.7	9.7	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852186	188527	None	0	Human	Binding	pKi	=	9.7	9.7	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028499	188527	None	0	Human	Binding	pKi	=	9.7	9.7	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164625454	188589	None	0	Human	Binding	pKi	=	9.7	9.7	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4862735	188589	None	0	Human	Binding	pKi	=	9.7	9.7	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028885	188589	None	0	Human	Binding	pKi	=	9.7	9.7	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	11798681	11147	None	0	Rat	Binding	pKi	=	9.7	9.7	-20	2	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
	CHEMBL1178344	11147	None	0	Rat	Binding	pKi	=	9.7	9.7	-20	2	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
	CHEMBL21905	11147	None	0	Rat	Binding	pKi	=	9.7	9.7	-20	2	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
	59291493	112820	None	0	Rat	Binding	pKi	=	9.7	9.7	-2	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298600	112820	None	0	Rat	Binding	pKi	=	9.7	9.7	-2	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307158	112820	None	0	Rat	Binding	pKi	=	9.7	9.7	-2	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	164627445	188605	None	0	Human	Binding	pKi	=	9.7	9.7	14	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4876453	188605	None	0	Human	Binding	pKi	=	9.7	9.7	14	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028997	188605	None	0	Human	Binding	pKi	=	9.7	9.7	14	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164628529	188612	None	0	Human	Binding	pKi	=	9.7	9.7	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	CHEMBL4876725	188612	None	0	Human	Binding	pKi	=	9.7	9.7	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	CHEMBL5029058	188612	None	0	Human	Binding	pKi	=	9.7	9.7	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	10101246	9544	None	0	Human	Binding	pKi	=	9.6	9.6	-81	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL112297	9544	None	0	Human	Binding	pKi	=	9.6	9.6	-81	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	164624669	188584	None	0	Human	Binding	pKi	=	9.6	9.6	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4870127	188584	None	0	Human	Binding	pKi	=	9.6	9.6	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028837	188584	None	0	Human	Binding	pKi	=	9.6	9.6	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	688566	195881	None	24	Rat	Binding	pKi	=	9.6	9.6	-1	3	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	CHEMBL558910	195881	None	24	Rat	Binding	pKi	=	9.6	9.6	-1	3	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	164624066	188578	None	0	Human	Binding	pKi	=	9.6	9.6	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4864987	188578	None	0	Human	Binding	pKi	=	9.6	9.6	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028806	188578	None	0	Human	Binding	pKi	=	9.6	9.6	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	155560305	176251	None	0	Human	Binding	pKi	=	9.6	9.6	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4568151	176251	None	0	Human	Binding	pKi	=	9.6	9.6	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4594890	176251	None	0	Human	Binding	pKi	=	9.6	9.6	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	164610746	188465	None	0	Human	Binding	pKi	=	9.6	9.6	34	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	188465	None	0	Human	Binding	pKi	=	9.6	9.6	34	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	188465	None	0	Human	Binding	pKi	=	9.6	9.6	34	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164621305	188550	None	0	Human	Binding	pKi	=	9.6	9.6	29	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4863285	188550	None	0	Human	Binding	pKi	=	9.6	9.6	29	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028642	188550	None	0	Human	Binding	pKi	=	9.6	9.6	29	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015900	178319	None	0	Human	Binding	pKi	=	9.6	9.6	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4643273	178319	None	0	Human	Binding	pKi	=	9.6	9.6	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651104	178319	None	0	Human	Binding	pKi	=	9.6	9.6	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	10324012	204704	None	0	Human	Binding	pKi	=	9.6	9.6	263	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL74117	204704	None	0	Human	Binding	pKi	=	9.6	9.6	263	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	10324012	204704	None	0	Human	Binding	pKi	=	9.6	9.6	263	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL74117	204704	None	0	Human	Binding	pKi	=	9.6	9.6	263	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	132947	3862	None	9	Human	Binding	pKi	=	9.6	9.6	1	9	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
	361	3862	None	9	Human	Binding	pKi	=	9.6	9.6	1	9	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
	CHEMBL265256	3862	None	9	Human	Binding	pKi	=	9.6	9.6	1	9	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
	155519740	170404	None	0	Human	Binding	pKi	=	9.6	9.6	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting method	ChEMBL	1125	29	4	14	9.6	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ncccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.8b01967
	CHEMBL4448108	170404	None	0	Human	Binding	pKi	=	9.6	9.6	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting method	ChEMBL	1125	29	4	14	9.6	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ncccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.8b01967
	156015724	178272	None	0	Human	Binding	pKi	=	9.6	9.6	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4643159	178272	None	0	Human	Binding	pKi	=	9.6	9.6	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650839	178272	None	0	Human	Binding	pKi	=	9.6	9.6	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	164610955	188467	None	0	Human	Binding	pKi	=	9.6	9.6	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	CHEMBL4858398	188467	None	0	Human	Binding	pKi	=	9.6	9.6	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	CHEMBL5028048	188467	None	0	Human	Binding	pKi	=	9.6	9.6	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	132947	3862	None	9	Rat	Binding	pKi	=	9.5	9.5	-1	9	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	361	3862	None	9	Rat	Binding	pKi	=	9.5	9.5	-1	9	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	CHEMBL265256	3862	None	9	Rat	Binding	pKi	=	9.5	9.5	-1	9	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	164619001	188534	None	0	Human	Binding	pKi	=	9.5	9.5	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4871153	188534	None	0	Human	Binding	pKi	=	9.5	9.5	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028529	188534	None	0	Human	Binding	pKi	=	9.5	9.5	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	132947	3862	None	9	Rat	Binding	pKi	=	9.5	9.5	-1	9	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	361	3862	None	9	Rat	Binding	pKi	=	9.5	9.5	-1	9	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	CHEMBL265256	3862	None	9	Rat	Binding	pKi	=	9.5	9.5	-1	9	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	44311771	164230	None	0	Human	Binding	pKi	=	9.5	9.5	34	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL421113	164230	None	0	Human	Binding	pKi	=	9.5	9.5	34	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311771	164230	None	0	Human	Binding	pKi	=	9.5	9.5	34	3	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL421113	164230	None	0	Human	Binding	pKi	=	9.5	9.5	34	3	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44311771	164230	None	0	Human	Binding	pKi	=	9.5	9.5	34	3	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL421113	164230	None	0	Human	Binding	pKi	=	9.5	9.5	34	3	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
	164628352	188611	None	0	Human	Binding	pKi	=	9.5	9.5	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4878717	188611	None	0	Human	Binding	pKi	=	9.5	9.5	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5029051	188611	None	0	Human	Binding	pKi	=	9.5	9.5	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44312007	169163	None	0	Human	Binding	pKi	=	9.5	9.5	34	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL440491	169163	None	0	Human	Binding	pKi	=	9.5	9.5	34	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44312007	169163	None	0	Human	Binding	pKi	=	9.5	9.5	34	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL440491	169163	None	0	Human	Binding	pKi	=	9.5	9.5	34	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	15463387	56533	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL163777	56533	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	44378810	57429	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.4	COc1ccc(S(=O)(=O)c2ccc(CN3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL165439	57429	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.4	COc1ccc(S(=O)(=O)c2ccc(CN3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	44378876	58134	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	615	6	0	8	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3sccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL167816	58134	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	615	6	0	8	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3sccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	44378952	119898	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)cc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL349142	119898	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)cc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	132947	3862	None	9	Human	Binding	pKi	=	9.5	9.5	1	9	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
	361	3862	None	9	Human	Binding	pKi	=	9.5	9.5	1	9	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
	CHEMBL265256	3862	None	9	Human	Binding	pKi	=	9.5	9.5	1	9	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
	132947	3862	None	9	Rat	Binding	pKi	=	9.5	9.5	-1	9	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	361	3862	None	9	Rat	Binding	pKi	=	9.5	9.5	-1	9	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	CHEMBL265256	3862	None	9	Rat	Binding	pKi	=	9.5	9.5	-1	9	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	164612662	188480	None	0	Human	Binding	pKi	=	9.5	9.5	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4847898	188480	None	0	Human	Binding	pKi	=	9.5	9.5	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028154	188480	None	0	Human	Binding	pKi	=	9.5	9.5	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44292836	101315	None	0	Rat	Binding	pKi	=	9.5	9.5	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
	CHEMBL296633	101315	None	0	Rat	Binding	pKi	=	9.5	9.5	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
	372625	101145	None	11	Human	Binding	pKi	=	9.5	9.5	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL295388	101145	None	11	Human	Binding	pKi	=	9.5	9.5	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	164613559	188484	None	0	Human	Binding	pKi	=	9.5	9.5	38	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4856659	188484	None	0	Human	Binding	pKi	=	9.5	9.5	38	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028196	188484	None	0	Human	Binding	pKi	=	9.5	9.5	38	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	372625	101145	None	11	Rat	Binding	pKi	=	9.5	9.5	-1	5	Displacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting methodDisplacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting method	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL295388	101145	None	11	Rat	Binding	pKi	=	9.5	9.5	-1	5	Displacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting methodDisplacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting method	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	367	3822	None	12	Human	Binding	pKi	=	9.5	9.5	-2	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	5487427	3822	None	12	Human	Binding	pKi	=	9.5	9.5	-2	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	8592	3822	None	12	Human	Binding	pKi	=	9.5	9.5	-2	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	9.5	9.5	-2	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	9.5	9.5	-2	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	9.5	9.5	-2	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	DB01409	3822	None	12	Human	Binding	pKi	=	9.5	9.5	-2	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	23724781	2833	None	19	Human	Binding	pKi	=	9.5	9.5	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	316	2833	None	19	Human	Binding	pKi	=	9.5	9.5	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	317	2833	None	19	Human	Binding	pKi	=	9.5	9.5	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	71183	2833	None	19	Human	Binding	pKi	=	9.5	9.5	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	9.5	9.5	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	9.5	9.5	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	9.5	9.5	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	DB00462	2833	None	19	Human	Binding	pKi	=	9.5	9.5	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	164619973	188539	None	0	Human	Binding	pKi	=	9.5	9.5	33	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4862996	188539	None	0	Human	Binding	pKi	=	9.5	9.5	33	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028571	188539	None	0	Human	Binding	pKi	=	9.5	9.5	33	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	174174	523	None	49	Human	Binding	pKi	=	9.5	9.5	-7	14	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
	260	523	None	49	Human	Binding	pKi	=	9.5	9.5	-7	14	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
	320	523	None	49	Human	Binding	pKi	=	9.5	9.5	-7	14	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	9.5	9.5	-7	14	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
	DB00572	523	None	49	Human	Binding	pKi	=	9.5	9.5	-7	14	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
	44311784	204477	None	0	Human	Binding	pKi	=	9.5	9.5	28	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72408	204477	None	0	Human	Binding	pKi	=	9.5	9.5	28	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	174174	523	None	49	Mouse	Binding	pKi	=	9.5	9.5	-1	14	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	260	523	None	49	Mouse	Binding	pKi	=	9.5	9.5	-1	14	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	320	523	None	49	Mouse	Binding	pKi	=	9.5	9.5	-1	14	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	CHEMBL517712	523	None	49	Mouse	Binding	pKi	=	9.5	9.5	-1	14	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	DB00572	523	None	49	Mouse	Binding	pKi	=	9.5	9.5	-1	14	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	44311784	204477	None	0	Human	Binding	pKi	=	9.5	9.5	28	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72408	204477	None	0	Human	Binding	pKi	=	9.5	9.5	28	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	137630050	161038	None	0	Human	Binding	pKi	=	9.5	9.5	1	5	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089543	161038	None	0	Human	Binding	pKi	=	9.5	9.5	1	5	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4097258	161038	None	0	Human	Binding	pKi	=	9.5	9.5	1	5	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4116470	161038	None	0	Human	Binding	pKi	=	9.5	9.5	1	5	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	164617401	188518	None	0	Human	Binding	pKi	=	9.5	9.5	12	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	CHEMBL4852646	188518	None	0	Human	Binding	pKi	=	9.5	9.5	12	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	CHEMBL5028427	188518	None	0	Human	Binding	pKi	=	9.5	9.5	12	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	155543944	176332	None	0	Human	Binding	pKi	=	9.5	9.5	8	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4567026	176332	None	0	Human	Binding	pKi	=	9.5	9.5	8	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595467	176332	None	0	Human	Binding	pKi	=	9.5	9.5	8	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	44311717	204487	None	0	Human	Binding	pKi	=	9.4	9.4	102	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72494	204487	None	0	Human	Binding	pKi	=	9.4	9.4	102	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311717	204487	None	0	Human	Binding	pKi	=	9.4	9.4	102	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72494	204487	None	0	Human	Binding	pKi	=	9.4	9.4	102	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	155535606	172050	None	0	Human	Binding	pKi	=	9.4	9.4	4	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	1077	20	5	12	6.0	CCC(=O)NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.8b01967
	CHEMBL4471882	172050	None	0	Human	Binding	pKi	=	9.4	9.4	4	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	1077	20	5	12	6.0	CCC(=O)NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.8b01967
	9953227	204195	None	0	Human	Binding	pKi	=	9.4	9.4	11	2	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	407	6	0	3	6.9	C=C(c1ccc(Sc2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	CHEMBL70828	204195	None	0	Human	Binding	pKi	=	9.4	9.4	11	2	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	407	6	0	3	6.9	C=C(c1ccc(Sc2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	10628017	21714	None	0	Rat	Binding	pKi	=	9.4	9.4	1	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL131865	21714	None	0	Rat	Binding	pKi	=	9.4	9.4	1	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	44311718	204469	None	0	Human	Binding	pKi	=	9.4	9.4	151	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72363	204469	None	0	Human	Binding	pKi	=	9.4	9.4	151	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44311760	204497	None	0	Human	Binding	pKi	=	9.4	9.4	109	3	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72551	204497	None	0	Human	Binding	pKi	=	9.4	9.4	109	3	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44292858	101345	None	0	Rat	Binding	pKi	=	9.4	9.4	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	397	7	1	4	3.5	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCCF)cc1	10.1021/jm00010a016
	CHEMBL296895	101345	None	0	Rat	Binding	pKi	=	9.4	9.4	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	397	7	1	4	3.5	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCCF)cc1	10.1021/jm00010a016
	44311718	204469	None	0	Human	Binding	pKi	=	9.4	9.4	151	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72363	204469	None	0	Human	Binding	pKi	=	9.4	9.4	151	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311760	204497	None	0	Human	Binding	pKi	=	9.4	9.4	109	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72551	204497	None	0	Human	Binding	pKi	=	9.4	9.4	109	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	164623076	188565	None	0	Human	Binding	pKi	=	9.4	9.4	17	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4872608	188565	None	0	Human	Binding	pKi	=	9.4	9.4	17	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028732	188565	None	0	Human	Binding	pKi	=	9.4	9.4	17	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	939077	195066	None	2	Rat	Binding	pKi	=	9.4	9.4	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	CHEMBL549577	195066	None	2	Rat	Binding	pKi	=	9.4	9.4	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	9809222	114091	None	0	Rat	Binding	pKi	=	9.4	9.4	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL332703	114091	None	0	Rat	Binding	pKi	=	9.4	9.4	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	44378764	57244	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	559	6	0	5	5.5	Cc1cccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c1	10.1016/s0960-894x(02)00024-0
	CHEMBL165035	57244	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	559	6	0	5	5.5	Cc1cccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c1	10.1016/s0960-894x(02)00024-0
	10291977	72896	None	0	Human	Binding	pKi	=	9.4	9.4	-5	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2ccsc2)c2ccsc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200401	72896	None	0	Human	Binding	pKi	=	9.4	9.4	-5	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2ccsc2)c2ccsc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44344122	110415	None	0	Rat	Binding	pKi	=	9.4	9.4	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL324484	110415	None	0	Rat	Binding	pKi	=	9.4	9.4	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	15870384	59235	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	576	6	0	7	5.0	Cc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CC3)CC2)c1C	10.1016/s0960-894x(01)00100-7
	CHEMBL170298	59235	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	576	6	0	7	5.0	Cc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CC3)CC2)c1C	10.1016/s0960-894x(01)00100-7
	134272442	176486	None	0	Human	Binding	pKi	=	9.4	9.4	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4457734	176486	None	0	Human	Binding	pKi	=	9.4	9.4	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596671	176486	None	0	Human	Binding	pKi	=	9.4	9.4	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	137630050	161038	None	0	Human	Binding	pKi	=	9.4	9.4	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pKi	=	9.4	9.4	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pKi	=	9.4	9.4	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pKi	=	9.4	9.4	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	44312024	204559	None	0	Human	Binding	pKi	=	9.4	9.4	36	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72957	204559	None	0	Human	Binding	pKi	=	9.4	9.4	36	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	137630050	161038	None	0	Human	Binding	pKi	=	9.4	9.4	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pKi	=	9.4	9.4	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pKi	=	9.4	9.4	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pKi	=	9.4	9.4	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	44312024	204559	None	0	Human	Binding	pKi	=	9.4	9.4	36	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72957	204559	None	0	Human	Binding	pKi	=	9.4	9.4	36	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	25897919	55650	None	14	Human	Binding	pKi	=	9.4	9.4	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	657308	55650	None	14	Human	Binding	pKi	=	9.4	9.4	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	657309	55650	None	14	Human	Binding	pKi	=	9.4	9.4	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	CHEMBL1464005	55650	None	14	Human	Binding	pKi	=	9.4	9.4	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	CHEMBL1621597	55650	None	14	Human	Binding	pKi	=	9.4	9.4	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	DB00332	55650	None	14	Human	Binding	pKi	=	9.4	9.4	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	155554568	176607	None	0	Human	Binding	pKi	=	9.4	9.4	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4548432	176607	None	0	Human	Binding	pKi	=	9.4	9.4	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597724	176607	None	0	Human	Binding	pKi	=	9.4	9.4	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	23724781	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	316	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	317	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	71183	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	DB00462	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	6604314	30977	None	3	Rat	Binding	pKi	=	9.4	9.4	-3	2	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	352	4	1	3	2.7	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm960374w
	CHEMBL1398637	30977	None	3	Rat	Binding	pKi	=	9.4	9.4	-3	2	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	352	4	1	3	2.7	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm960374w
	11434515	261	None	6	Human	Binding	pKi	=	9.4	9.4	-6	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	11519741	261	None	6	Human	Binding	pKi	=	9.4	9.4	-6	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	4484	261	None	6	Human	Binding	pKi	=	9.4	9.4	-6	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	7449	261	None	6	Human	Binding	pKi	=	9.4	9.4	-6	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	CHEMBL1194325	261	None	6	Human	Binding	pKi	=	9.4	9.4	-6	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	DB08897	261	None	6	Human	Binding	pKi	=	9.4	9.4	-6	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	23724781	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	316	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	317	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	71183	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	DB00462	2833	None	19	Human	Binding	pKi	=	9.4	9.4	-6	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	11766733	155752	None	0	Rat	Binding	pKi	=	9.4	9.4	-2	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202003	155752	None	0	Rat	Binding	pKi	=	9.4	9.4	-2	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL405739	155752	None	0	Rat	Binding	pKi	=	9.4	9.4	-2	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	44344164	10983	None	0	Rat	Binding	pKi	=	9.4	9.4	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)cc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL117351	10983	None	0	Rat	Binding	pKi	=	9.4	9.4	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)cc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	44311823	204202	None	0	Human	Binding	pKi	=	9.4	9.4	23	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL70860	204202	None	0	Human	Binding	pKi	=	9.4	9.4	23	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311823	204202	None	0	Human	Binding	pKi	=	9.4	9.4	23	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL70860	204202	None	0	Human	Binding	pKi	=	9.4	9.4	23	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	688520	35413	None	3	Human	Binding	pKi	=	9.4	9.4	4	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	CHEMBL1437876	35413	None	3	Human	Binding	pKi	=	9.4	9.4	4	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	CHEMBL3289390	35413	None	3	Human	Binding	pKi	=	9.4	9.4	4	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	44311987	204600	None	0	Human	Binding	pKi	=	9.3	9.3	162	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL73245	204600	None	0	Human	Binding	pKi	=	9.3	9.3	162	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	59291402	112784	None	0	Rat	Binding	pKi	=	9.3	9.3	-8	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298588	112784	None	0	Rat	Binding	pKi	=	9.3	9.3	-8	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305766	112784	None	0	Rat	Binding	pKi	=	9.3	9.3	-8	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	44311987	204600	None	0	Human	Binding	pKi	=	9.3	9.3	162	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL73245	204600	None	0	Human	Binding	pKi	=	9.3	9.3	162	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	16116083	12294	None	0	Human	Binding	pKi	=	9.3	9.3	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL1184884	12294	None	0	Human	Binding	pKi	=	9.3	9.3	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL375969	12294	None	0	Human	Binding	pKi	=	9.3	9.3	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	129486	100153	None	6	Human	Binding	pKi	=	9.3	9.3	-5	2	Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3	ChEMBL	349	4	0	3	4.0	CN1CC2CC(OC(=O)C(C)(c3ccccc3)c3ccccc3)CC1C2	10.1021/jm00108a030
	CHEMBL287868	100153	None	6	Human	Binding	pKi	=	9.3	9.3	-5	2	Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3	ChEMBL	349	4	0	3	4.0	CN1CC2CC(OC(=O)C(C)(c3ccccc3)c3ccccc3)CC1C2	10.1021/jm00108a030
	25897919	55650	None	14	Human	Binding	pKi	=	9.3	9.3	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	657308	55650	None	14	Human	Binding	pKi	=	9.3	9.3	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	657309	55650	None	14	Human	Binding	pKi	=	9.3	9.3	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	CHEMBL1464005	55650	None	14	Human	Binding	pKi	=	9.3	9.3	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	CHEMBL1621597	55650	None	14	Human	Binding	pKi	=	9.3	9.3	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	DB00332	55650	None	14	Human	Binding	pKi	=	9.3	9.3	-1	8	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	367	3822	None	12	Human	Binding	pKi	=	9.3	9.3	-2	8	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	5487427	3822	None	12	Human	Binding	pKi	=	9.3	9.3	-2	8	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	8592	3822	None	12	Human	Binding	pKi	=	9.3	9.3	-2	8	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	9.3	9.3	-2	8	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	9.3	9.3	-2	8	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	9.3	9.3	-2	8	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	DB01409	3822	None	12	Human	Binding	pKi	=	9.3	9.3	-2	8	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	155520948	176427	None	0	Human	Binding	pKi	=	9.3	9.3	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4450188	176427	None	0	Human	Binding	pKi	=	9.3	9.3	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596191	176427	None	0	Human	Binding	pKi	=	9.3	9.3	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	44379040	120110	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	1	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3N)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL351079	120110	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	1	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3N)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	302	2975	None	25	Rat	Binding	pKi	=	9.3	9.3	-4	8	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	4630	2975	None	25	Rat	Binding	pKi	=	9.3	9.3	-4	8	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL7634	2975	None	25	Rat	Binding	pKi	=	9.3	9.3	-4	8	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	302	2975	None	25	Rat	Binding	pKi	=	9.3	9.3	-4	8	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	4630	2975	None	25	Rat	Binding	pKi	=	9.3	9.3	-4	8	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL7634	2975	None	25	Rat	Binding	pKi	=	9.3	9.3	-4	8	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	9851621	59177	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	6	0	7	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL170033	59177	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	6	0	7	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	44382606	120793	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2ncccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL355511	120793	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2ncccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	44232952	103381	None	0	Human	Binding	pKi	=	9.3	9.3	-10	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084650	103381	None	0	Human	Binding	pKi	=	9.3	9.3	-10	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10009554	204709	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/acs.jmedchem.1c00790
	CHEMBL74141	204709	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/acs.jmedchem.1c00790
	10009554	204709	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/jm0255163
	CHEMBL74141	204709	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/jm0255163
	44215377	12090	None	0	Rat	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(F)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL118391	12090	None	0	Rat	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(F)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	137630050	161038	None	0	Human	Binding	pKi	=	9.3	9.3	1	5	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089543	161038	None	0	Human	Binding	pKi	=	9.3	9.3	1	5	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4097258	161038	None	0	Human	Binding	pKi	=	9.3	9.3	1	5	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4116470	161038	None	0	Human	Binding	pKi	=	9.3	9.3	1	5	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	156015807	178297	None	0	Human	Binding	pKi	=	9.3	9.3	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178297	None	0	Human	Binding	pKi	=	9.3	9.3	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178297	None	0	Human	Binding	pKi	=	9.3	9.3	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	44344216	13228	None	0	Rat	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(N)ccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL119131	13228	None	0	Rat	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(N)ccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	44344106	113070	None	0	Rat	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL331214	113070	None	0	Rat	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	44343862	10509	None	0	Rat	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	604	7	0	7	5.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL116777	10509	None	0	Rat	Binding	pKi	=	9.3	9.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	604	7	0	7	5.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	10771937	21691	None	0	Rat	Binding	pKi	=	9.3	9.3	2	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202004	21691	None	0	Rat	Binding	pKi	=	9.3	9.3	2	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL131846	21691	None	0	Rat	Binding	pKi	=	9.3	9.3	2	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	23724781	2833	None	19	Human	Binding	pKi	=	9.2	9.2	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	316	2833	None	19	Human	Binding	pKi	=	9.2	9.2	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	317	2833	None	19	Human	Binding	pKi	=	9.2	9.2	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	71183	2833	None	19	Human	Binding	pKi	=	9.2	9.2	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	9.2	9.2	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	9.2	9.2	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	9.2	9.2	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	DB00462	2833	None	19	Human	Binding	pKi	=	9.2	9.2	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	164616706	188513	None	0	Human	Binding	pKi	=	9.2	9.2	6	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4850130	188513	None	0	Human	Binding	pKi	=	9.2	9.2	6	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028391	188513	None	0	Human	Binding	pKi	=	9.2	9.2	6	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015042	178232	None	0	Human	Binding	pKi	=	9.2	9.2	-1	2	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
	CHEMBL4645845	178232	None	0	Human	Binding	pKi	=	9.2	9.2	-1	2	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650549	178232	None	0	Human	Binding	pKi	=	9.2	9.2	-1	2	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
	44311785	204735	None	0	Human	Binding	pKi	=	9.2	9.2	69	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL74352	204735	None	0	Human	Binding	pKi	=	9.2	9.2	69	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44311785	204735	None	0	Human	Binding	pKi	=	9.2	9.2	69	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL74352	204735	None	0	Human	Binding	pKi	=	9.2	9.2	69	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44312451	104784	None	0	Human	Binding	pKi	=	9.2	9.2	10	2	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL310912	104784	None	0	Human	Binding	pKi	=	9.2	9.2	10	2	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	15407073	119958	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL349720	119958	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	44379055	120513	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	8	0	7	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1	10.1016/s0960-894x(02)00024-0
	CHEMBL354534	120513	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	8	0	7	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1	10.1016/s0960-894x(02)00024-0
	44312451	104784	None	0	Human	Binding	pKi	=	9.2	9.2	10	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL310912	104784	None	0	Human	Binding	pKi	=	9.2	9.2	10	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	44312450	204834	None	0	Human	Binding	pKi	=	9.2	9.2	13	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	446	5	0	4	5.2	CC(c1ccc(S(=O)(=O)c2ccc(Cl)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL75448	204834	None	0	Human	Binding	pKi	=	9.2	9.2	13	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	446	5	0	4	5.2	CC(c1ccc(S(=O)(=O)c2ccc(Cl)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	154734599	2501	None	12	Human	Binding	pKi	=	9.2	9.2	1	12	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
	327	2501	None	12	Human	Binding	pKi	=	9.2	9.2	1	12	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
	4108	2501	None	12	Human	Binding	pKi	=	9.2	9.2	1	12	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	9.2	9.2	1	12	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
	CHEMBL5289667	194473	None	0	Human	Binding	pKi	=	9.2	9.2	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	959	21	2	5	13.8	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
	156015978	178321	None	0	Human	Binding	pKi	=	9.2	9.2	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178321	None	0	Human	Binding	pKi	=	9.2	9.2	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178321	None	0	Human	Binding	pKi	=	9.2	9.2	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	25006208	112823	None	0	Rat	Binding	pKi	=	9.2	9.2	-5	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298763	112823	None	0	Rat	Binding	pKi	=	9.2	9.2	-5	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307197	112823	None	0	Rat	Binding	pKi	=	9.2	9.2	-5	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	44431384	148858	None	0	Human	Binding	pKi	=	9.2	9.2	2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL394137	148858	None	0	Human	Binding	pKi	=	9.2	9.2	2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	44344145	11014	None	0	Rat	Binding	pKi	=	9.2	9.2	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(F)ccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL117414	11014	None	0	Rat	Binding	pKi	=	9.2	9.2	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(F)ccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	56667296	176639	None	0	Human	Binding	pKi	=	9.2	9.2	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4461243	176639	None	0	Human	Binding	pKi	=	9.2	9.2	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597972	176639	None	0	Human	Binding	pKi	=	9.2	9.2	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	10470	2486	None	7	Human	Binding	pKi	=	9.2	9.2	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
	1689	2486	None	7	Human	Binding	pKi	=	9.2	9.2	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
	4057	2486	None	7	Human	Binding	pKi	=	9.2	9.2	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
	CHEMBL524004	2486	None	7	Human	Binding	pKi	=	9.2	9.2	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
	DB04843	2486	None	7	Human	Binding	pKi	=	9.2	9.2	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
	155512178	176487	None	0	Human	Binding	pKi	=	9.2	9.2	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4436930	176487	None	0	Human	Binding	pKi	=	9.2	9.2	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596672	176487	None	0	Human	Binding	pKi	=	9.2	9.2	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	174174	523	None	49	Mouse	Binding	pKi	=	9.2	9.2	-1	14	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	260	523	None	49	Mouse	Binding	pKi	=	9.2	9.2	-1	14	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	320	523	None	49	Mouse	Binding	pKi	=	9.2	9.2	-1	14	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	CHEMBL517712	523	None	49	Mouse	Binding	pKi	=	9.2	9.2	-1	14	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	DB00572	523	None	49	Mouse	Binding	pKi	=	9.2	9.2	-1	14	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	174174	523	None	49	Rat	Binding	pKi	=	9.2	9.2	-4	14	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	260	523	None	49	Rat	Binding	pKi	=	9.2	9.2	-4	14	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	320	523	None	49	Rat	Binding	pKi	=	9.2	9.2	-4	14	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	CHEMBL517712	523	None	49	Rat	Binding	pKi	=	9.2	9.2	-4	14	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	DB00572	523	None	49	Rat	Binding	pKi	=	9.2	9.2	-4	14	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	10393100	56529	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	563	7	0	8	3.1	CCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	CHEMBL163714	56529	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	563	7	0	8	3.1	CCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	44267748	12933	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	516	7	0	5	5.7	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11892	12933	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	516	7	0	5	5.7	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	137628879	160970	None	0	Human	Binding	pKi	=	9.2	9.2	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4068393	160970	None	0	Human	Binding	pKi	=	9.2	9.2	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4079233	160970	None	0	Human	Binding	pKi	=	9.2	9.2	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4115977	160970	None	0	Human	Binding	pKi	=	9.2	9.2	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	137628879	160970	None	0	Human	Binding	pKi	=	9.2	9.2	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4068393	160970	None	0	Human	Binding	pKi	=	9.2	9.2	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4079233	160970	None	0	Human	Binding	pKi	=	9.2	9.2	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4115977	160970	None	0	Human	Binding	pKi	=	9.2	9.2	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	44324655	168137	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	7	0	8	4.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL433011	168137	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	7	0	8	4.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	44343761	111290	None	0	Rat	Binding	pKi	=	9.1	9.1	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	638	7	0	7	5.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL326561	111290	None	0	Rat	Binding	pKi	=	9.1	9.1	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	638	7	0	7	5.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	134272452	176672	None	0	Human	Binding	pKi	=	9.1	9.1	-1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4448944	176672	None	0	Human	Binding	pKi	=	9.1	9.1	-1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4598232	176672	None	0	Human	Binding	pKi	=	9.1	9.1	-1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	23724781	2833	None	19	Human	Binding	pKi	=	9.1	9.1	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	316	2833	None	19	Human	Binding	pKi	=	9.1	9.1	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	317	2833	None	19	Human	Binding	pKi	=	9.1	9.1	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	71183	2833	None	19	Human	Binding	pKi	=	9.1	9.1	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	9.1	9.1	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	9.1	9.1	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	9.1	9.1	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	DB00462	2833	None	19	Human	Binding	pKi	=	9.1	9.1	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	11223598	106523	None	0	Human	Binding	pKi	=	9.1	9.1	-2	3	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
	CHEMBL3084413	106523	None	0	Human	Binding	pKi	=	9.1	9.1	-2	3	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
	CHEMBL3140264	106523	None	0	Human	Binding	pKi	=	9.1	9.1	-2	3	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
	16125331	136960	None	0	Human	Binding	pKi	=	9.1	9.1	-1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	7	1	1	4.8	C[N+]1(CCCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL374452	136960	None	0	Human	Binding	pKi	=	9.1	9.1	-1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	7	1	1	4.8	C[N+]1(CCCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	122203596	155804	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	174174	523	None	49	Rat	Binding	pKi	=	9.1	9.1	-4	14	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
	260	523	None	49	Rat	Binding	pKi	=	9.1	9.1	-4	14	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
	320	523	None	49	Rat	Binding	pKi	=	9.1	9.1	-4	14	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
	CHEMBL517712	523	None	49	Rat	Binding	pKi	=	9.1	9.1	-4	14	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
	DB00572	523	None	49	Rat	Binding	pKi	=	9.1	9.1	-4	14	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
	174174	523	None	49	Rat	Binding	pKi	=	9.1	9.1	-4	14	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
	260	523	None	49	Rat	Binding	pKi	=	9.1	9.1	-4	14	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
	320	523	None	49	Rat	Binding	pKi	=	9.1	9.1	-4	14	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
	CHEMBL517712	523	None	49	Rat	Binding	pKi	=	9.1	9.1	-4	14	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
	DB00572	523	None	49	Rat	Binding	pKi	=	9.1	9.1	-4	14	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
	122203596	155804	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	16115945	12295	None	0	Human	Binding	pKi	=	9.1	9.1	-9	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1184886	12295	None	0	Human	Binding	pKi	=	9.1	9.1	-9	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL376057	12295	None	0	Human	Binding	pKi	=	9.1	9.1	-9	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	303	2976	None	17	Rat	Binding	pKi	=	9.1	9.1	1	6	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	4629	2976	None	17	Rat	Binding	pKi	=	9.1	9.1	1	6	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	8595	2976	None	17	Rat	Binding	pKi	=	9.1	9.1	1	6	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL44674	2976	None	17	Rat	Binding	pKi	=	9.1	9.1	1	6	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	44344132	110358	None	0	Rat	Binding	pKi	=	9.1	9.1	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL324116	110358	None	0	Rat	Binding	pKi	=	9.1	9.1	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	25897919	55650	None	14	Rat	Binding	pKi	=	9.1	9.1	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	657308	55650	None	14	Rat	Binding	pKi	=	9.1	9.1	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	657309	55650	None	14	Rat	Binding	pKi	=	9.1	9.1	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL1464005	55650	None	14	Rat	Binding	pKi	=	9.1	9.1	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL1621597	55650	None	14	Rat	Binding	pKi	=	9.1	9.1	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	DB00332	55650	None	14	Rat	Binding	pKi	=	9.1	9.1	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	9946298	72825	None	0	Human	Binding	pKi	=	9.1	9.1	-3	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200171	72825	None	0	Human	Binding	pKi	=	9.1	9.1	-3	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10291366	140697	None	0	Human	Binding	pKi	=	9.1	9.1	-4	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381623	140697	None	0	Human	Binding	pKi	=	9.1	9.1	-4	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	25897919	55650	None	14	Human	Binding	pKi	=	9.1	9.1	-1	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
	657308	55650	None	14	Human	Binding	pKi	=	9.1	9.1	-1	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
	657309	55650	None	14	Human	Binding	pKi	=	9.1	9.1	-1	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
	CHEMBL1464005	55650	None	14	Human	Binding	pKi	=	9.1	9.1	-1	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
	CHEMBL1621597	55650	None	14	Human	Binding	pKi	=	9.1	9.1	-1	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
	DB00332	55650	None	14	Human	Binding	pKi	=	9.1	9.1	-1	8	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
	122203596	155804	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
	CHEMBL4059733	155804	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
	CHEMBL4066481	155804	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
	156016041	178245	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178245	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178245	None	0	Human	Binding	pKi	=	9.1	9.1	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	10291366	140697	None	0	Human	Binding	pKi	=	9.1	9.1	-4	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL381623	140697	None	0	Human	Binding	pKi	=	9.1	9.1	-4	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	456615	102744	None	1	Human	Binding	pKi	=	9.1	9.1	-	1	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL305026	102744	None	1	Human	Binding	pKi	=	9.1	9.1	-	1	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	44378689	56523	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	611	7	0	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	CHEMBL163658	56523	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	611	7	0	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	44378958	9247	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL110744	9247	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	456615	102744	None	1	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL305026	102744	None	1	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	44312083	204485	None	0	Human	Binding	pKi	=	9.1	9.1	13	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	5	0	4	4.8	Cc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL72455	204485	None	0	Human	Binding	pKi	=	9.1	9.1	13	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	5	0	4	4.8	Cc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	59291259	112471	None	1	Rat	Binding	pKi	=	9.1	9.1	-3	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.6	O=C(Nc1ncsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298591	112471	None	1	Rat	Binding	pKi	=	9.1	9.1	-3	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.6	O=C(Nc1ncsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	174174	523	None	49	Human	Binding	pKi	=	9.1	9.1	-7	14	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	260	523	None	49	Human	Binding	pKi	=	9.1	9.1	-7	14	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	320	523	None	49	Human	Binding	pKi	=	9.1	9.1	-7	14	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	9.1	9.1	-7	14	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	DB00572	523	None	49	Human	Binding	pKi	=	9.1	9.1	-7	14	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	10919522	78916	None	0	Human	Binding	pKi	=	9.1	9.1	-3	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	688	11	1	4	6.8	O=C(NC[C@H]1CCCN(CC2CCCCC2)C1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm010480k
	CHEMBL2112957	78916	None	0	Human	Binding	pKi	=	9.1	9.1	-3	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	688	11	1	4	6.8	O=C(NC[C@H]1CCCN(CC2CCCCC2)C1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm010480k
	44325017	206855	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	622	8	0	8	5.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL90638	206855	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	622	8	0	8	5.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	59291413	112785	None	0	Rat	Binding	pKi	=	9.1	9.1	-4	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298589	112785	None	0	Rat	Binding	pKi	=	9.1	9.1	-4	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305767	112785	None	0	Rat	Binding	pKi	=	9.1	9.1	-4	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	44325047	207260	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	8	0	8	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL93017	207260	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	8	0	8	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	16115947	11847	None	0	Human	Binding	pKi	=	9.1	9.1	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1182214	11847	None	0	Human	Binding	pKi	=	9.1	9.1	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL222259	11847	None	0	Human	Binding	pKi	=	9.1	9.1	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	164620907	188546	None	0	Human	Binding	pKi	=	9.1	9.1	47	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4865939	188546	None	0	Human	Binding	pKi	=	9.1	9.1	47	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028619	188546	None	0	Human	Binding	pKi	=	9.1	9.1	47	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	10474247	101402	None	0	Rat	Binding	pKi	=	9.1	9.1	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	CHEMBL297276	101402	None	0	Rat	Binding	pKi	=	9.1	9.1	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	44344078	110769	None	0	Rat	Binding	pKi	=	9.1	9.1	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	636	7	0	7	6.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)SCCS3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL326057	110769	None	0	Rat	Binding	pKi	=	9.1	9.1	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	636	7	0	7	6.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)SCCS3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	9894173	15148	None	4	Human	Binding	pKi	=	9.1	9.1	69	5	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	CHEMBL12098	15148	None	4	Human	Binding	pKi	=	9.1	9.1	69	5	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	10163651	163231	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL418446	163231	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1016/j.bmcl.2004.01.033
	9894173	15148	None	4	Human	Binding	pKi	=	9.1	9.1	69	5	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	CHEMBL12098	15148	None	4	Human	Binding	pKi	=	9.1	9.1	69	5	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	9894173	15148	None	4	Human	Binding	pKi	=	9.1	9.1	69	5	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm0255163
	CHEMBL12098	15148	None	4	Human	Binding	pKi	=	9.1	9.1	69	5	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm0255163
	10163651	163231	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL418446	163231	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	9894173	15148	None	4	Human	Binding	pKi	=	9.1	9.1	69	5	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm301774u
	CHEMBL12098	15148	None	4	Human	Binding	pKi	=	9.1	9.1	69	5	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm301774u
	15407073	119958	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	CHEMBL349720	119958	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	44267782	98518	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL276239	98518	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44267782	98518	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
	CHEMBL276239	98518	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
	20689406	111359	None	0	Rat	Binding	pKi	=	9.1	9.1	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	8	1	8	4.8	CNc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
	CHEMBL326990	111359	None	0	Rat	Binding	pKi	=	9.1	9.1	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	8	1	8	4.8	CNc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
	174174	523	None	49	Human	Binding	pKi	=	9.1	9.1	-7	14	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
	260	523	None	49	Human	Binding	pKi	=	9.1	9.1	-7	14	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
	320	523	None	49	Human	Binding	pKi	=	9.1	9.1	-7	14	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	9.1	9.1	-7	14	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
	DB00572	523	None	49	Human	Binding	pKi	=	9.1	9.1	-7	14	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
	134272503	176409	None	0	Human	Binding	pKi	=	9.0	9.0	8	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	CHEMBL4545504	176409	None	0	Human	Binding	pKi	=	9.0	9.0	8	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596068	176409	None	0	Human	Binding	pKi	=	9.0	9.0	8	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	174174	523	None	49	Human	Binding	pKi	=	9.0	9.0	-7	14	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	523	None	49	Human	Binding	pKi	=	9.0	9.0	-7	14	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	523	None	49	Human	Binding	pKi	=	9.0	9.0	-7	14	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	9.0	9.0	-7	14	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	523	None	49	Human	Binding	pKi	=	9.0	9.0	-7	14	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	10486393	141700	None	0	Rat	Binding	pKi	=	9.0	9.0	2	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202000	141700	None	0	Rat	Binding	pKi	=	9.0	9.0	2	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL385625	141700	None	0	Rat	Binding	pKi	=	9.0	9.0	2	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL5270870	193655	None	0	Human	Binding	pKi	=	9.0	9.0	-6	3	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	507	12	2	4	6.8	NCCCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	164618698	188531	None	0	Human	Binding	pKi	=	9.0	9.0	43	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4862098	188531	None	0	Human	Binding	pKi	=	9.0	9.0	43	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028512	188531	None	0	Human	Binding	pKi	=	9.0	9.0	43	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015645	178296	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4638411	178296	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650970	178296	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	11691950	12760	None	0	Human	Binding	pKi	=	9.0	9.0	-2	3	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL1187853	12760	None	0	Human	Binding	pKi	=	9.0	9.0	-2	3	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL524097	12760	None	0	Human	Binding	pKi	=	9.0	9.0	-2	3	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	16116085	11844	None	0	Human	Binding	pKi	=	9.0	9.0	-9	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1182201	11844	None	0	Human	Binding	pKi	=	9.0	9.0	-9	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL219786	11844	None	0	Human	Binding	pKi	=	9.0	9.0	-9	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	44311786	103048	None	0	Human	Binding	pKi	=	9	9.0	60	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL307234	103048	None	0	Human	Binding	pKi	=	9	9.0	60	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44311786	103048	None	0	Human	Binding	pKi	=	9	9.0	60	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL307234	103048	None	0	Human	Binding	pKi	=	9	9.0	60	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	463517	203700	None	1	Human	Binding	pKi	=	9	9.0	436	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	589	6	0	7	4.8	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL67563	203700	None	1	Human	Binding	pKi	=	9	9.0	436	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	589	6	0	7	4.8	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	10180872	103127	None	0	Human	Binding	pKi	=	9	9.0	-1	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL307810	103127	None	0	Human	Binding	pKi	=	9	9.0	-1	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	44378951	57428	None	0	Human	Binding	pKi	=	9	9.0	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	591	6	1	8	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3O)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL165434	57428	None	0	Human	Binding	pKi	=	9	9.0	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	591	6	1	8	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3O)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	44267696	11029	None	0	Human	Binding	pKi	=	9	9.0	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ncccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11756	11029	None	0	Human	Binding	pKi	=	9	9.0	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ncccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44343902	11134	None	0	Rat	Binding	pKi	=	9	9.0	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C(F)(F)F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL117817	11134	None	0	Rat	Binding	pKi	=	9	9.0	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C(F)(F)F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	9938599	58711	None	0	Human	Binding	pKi	=	9	9.0	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL168483	58711	None	0	Human	Binding	pKi	=	9	9.0	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	174174	523	None	49	Human	Binding	pKi	=	9	9.0	-7	14	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
	260	523	None	49	Human	Binding	pKi	=	9	9.0	-7	14	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
	320	523	None	49	Human	Binding	pKi	=	9	9.0	-7	14	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	9	9.0	-7	14	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
	DB00572	523	None	49	Human	Binding	pKi	=	9	9.0	-7	14	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
	10180872	103127	None	0	Human	Binding	pKi	=	9	9.0	-1	4	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL307810	103127	None	0	Human	Binding	pKi	=	9	9.0	-1	4	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	155522355	176407	None	0	Human	Binding	pKi	=	9	9.0	31	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4451030	176407	None	0	Human	Binding	pKi	=	9	9.0	31	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4596065	176407	None	0	Human	Binding	pKi	=	9	9.0	31	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	134272501	176579	None	0	Human	Binding	pKi	=	9	9.0	-2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4483083	176579	None	0	Human	Binding	pKi	=	9	9.0	-2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597500	176579	None	0	Human	Binding	pKi	=	9	9.0	-2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	44325052	206958	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	562	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL91232	206958	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	562	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	25897919	55650	None	14	Human	Binding	pKi	=	9.0	9.0	-1	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	657308	55650	None	14	Human	Binding	pKi	=	9.0	9.0	-1	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	657309	55650	None	14	Human	Binding	pKi	=	9.0	9.0	-1	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	CHEMBL1464005	55650	None	14	Human	Binding	pKi	=	9.0	9.0	-1	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	CHEMBL1621597	55650	None	14	Human	Binding	pKi	=	9.0	9.0	-1	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	DB00332	55650	None	14	Human	Binding	pKi	=	9.0	9.0	-1	8	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	137630050	161038	None	0	Human	Binding	pKi	=	9.0	9.0	1	5	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161038	None	0	Human	Binding	pKi	=	9.0	9.0	1	5	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161038	None	0	Human	Binding	pKi	=	9.0	9.0	1	5	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161038	None	0	Human	Binding	pKi	=	9.0	9.0	1	5	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	127044	78908	None	1	Rat	Binding	pKi	=	9.0	9.0	-3	3	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	427	5	1	4	2.9	O=C(OC1CN2CCC1CC2)C(O)(CC=CI)c1ccccc1	10.1021/jm00059a009
	CHEMBL2112942	78908	None	1	Rat	Binding	pKi	=	9.0	9.0	-3	3	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	427	5	1	4	2.9	O=C(OC1CN2CCC1CC2)C(O)(CC=CI)c1ccccc1	10.1021/jm00059a009
	16115797	138153	None	0	Human	Binding	pKi	=	9.0	9.0	-3	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL376870	138153	None	0	Human	Binding	pKi	=	9.0	9.0	-3	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	155522355	176407	None	0	Human	Binding	pKi	=	9.0	9.0	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176407	None	0	Human	Binding	pKi	=	9.0	9.0	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176407	None	0	Human	Binding	pKi	=	9.0	9.0	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	155522355	176407	None	0	Human	Binding	pKi	=	9.0	9.0	31	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176407	None	0	Human	Binding	pKi	=	9.0	9.0	31	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176407	None	0	Human	Binding	pKi	=	9.0	9.0	31	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	122203596	155804	None	0	Human	Binding	pKi	=	9.0	9.0	1	5	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pKi	=	9.0	9.0	1	5	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pKi	=	9.0	9.0	1	5	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	10437400	194283	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	544	6	2	5	4.5	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5cccc6[nH]ccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL52852	194283	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	544	6	2	5	4.5	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5cccc6[nH]ccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	44344248	114090	None	0	Rat	Binding	pKi	=	9.0	9.0	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL332702	114090	None	0	Rat	Binding	pKi	=	9.0	9.0	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	9872651	165112	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	6	0	8	4.8	O=C(Oc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL422740	165112	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	6	0	8	4.8	O=C(Oc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL5289601	194470	None	0	Human	Binding	pKi	=	9.0	9.0	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	973	22	2	5	14.1	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
	145148382	176612	None	0	Human	Binding	pKi	=	9.0	9.0	-1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	CHEMBL4590868	176612	None	0	Human	Binding	pKi	=	9.0	9.0	-1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597793	176612	None	0	Human	Binding	pKi	=	9.0	9.0	-1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	23724781	2833	None	19	Human	Binding	pKi	=	9.0	9.0	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	316	2833	None	19	Human	Binding	pKi	=	9.0	9.0	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	317	2833	None	19	Human	Binding	pKi	=	9.0	9.0	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	71183	2833	None	19	Human	Binding	pKi	=	9.0	9.0	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	9.0	9.0	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	9.0	9.0	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	9.0	9.0	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	DB00462	2833	None	19	Human	Binding	pKi	=	9.0	9.0	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	44311762	163470	None	0	Human	Binding	pKi	=	8.9	8.9	2	3	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL420008	163470	None	0	Human	Binding	pKi	=	8.9	8.9	2	3	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/s0960-894x(00)00457-1
	44311762	163470	None	0	Human	Binding	pKi	=	8.9	8.9	2	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL420008	163470	None	0	Human	Binding	pKi	=	8.9	8.9	2	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/j.bmcl.2007.01.058
	5284632	67400	None	13	Human	Binding	pKi	=	8.9	8.9	-1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
	CHEMBL1888176	67400	None	13	Human	Binding	pKi	=	8.9	8.9	-1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
	CHEMBL3084748	67400	None	13	Human	Binding	pKi	=	8.9	8.9	-1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
	DB00209	67400	None	13	Human	Binding	pKi	=	8.9	8.9	-1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
	23724781	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	316	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	317	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	71183	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	DB00462	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	164620270	188540	None	0	Human	Binding	pKi	=	8.9	8.9	50	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4869723	188540	None	0	Human	Binding	pKi	=	8.9	8.9	50	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028587	188540	None	0	Human	Binding	pKi	=	8.9	8.9	50	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44343901	110312	None	0	Rat	Binding	pKi	=	8.9	8.9	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	620	8	0	8	4.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6OC)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL323850	110312	None	0	Rat	Binding	pKi	=	8.9	8.9	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	620	8	0	8	4.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6OC)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	59291327	112815	None	0	Rat	Binding	pKi	=	8.9	8.9	-3	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL3298597	112815	None	0	Rat	Binding	pKi	=	8.9	8.9	-3	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL3307126	112815	None	0	Rat	Binding	pKi	=	8.9	8.9	-3	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	59291513	112816	None	0	Rat	Binding	pKi	=	8.9	8.9	-4	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL3298598	112816	None	0	Rat	Binding	pKi	=	8.9	8.9	-4	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL3307127	112816	None	0	Rat	Binding	pKi	=	8.9	8.9	-4	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
	23724781	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	316	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	317	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	71183	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	DB00462	2833	None	19	Human	Binding	pKi	=	8.9	8.9	-6	9	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	44325034	206837	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	634	8	0	9	4.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL90507	206837	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	634	8	0	9	4.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	25897919	55650	None	14	Human	Binding	pKi	=	8.9	8.9	-1	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
	657308	55650	None	14	Human	Binding	pKi	=	8.9	8.9	-1	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
	657309	55650	None	14	Human	Binding	pKi	=	8.9	8.9	-1	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
	CHEMBL1464005	55650	None	14	Human	Binding	pKi	=	8.9	8.9	-1	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
	CHEMBL1621597	55650	None	14	Human	Binding	pKi	=	8.9	8.9	-1	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
	DB00332	55650	None	14	Human	Binding	pKi	=	8.9	8.9	-1	8	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
	10275847	203997	None	0	Human	Binding	pKi	=	8.9	8.9	12	2	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	452	6	0	5	5.2	COc1ccc(S(=O)(=O)c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL69595	203997	None	0	Human	Binding	pKi	=	8.9	8.9	12	2	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	452	6	0	5	5.2	COc1ccc(S(=O)(=O)c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	44378597	57414	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	555	8	0	7	4.5	CCCCC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	CHEMBL165337	57414	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	555	8	0	7	4.5	CCCCC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	44379052	120429	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	539	6	0	7	3.7	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)C3CC3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL353842	120429	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	539	6	0	7	3.7	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)C3CC3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	10119364	43248	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL150624	43248	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	44406481	72873	None	0	Human	Binding	pKi	=	8.9	8.9	-2	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200319	72873	None	0	Human	Binding	pKi	=	8.9	8.9	-2	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	71462570	82564	None	0	Human	Binding	pKi	=	8.9	8.9	-1	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	518	5	2	5	5.6	CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O	10.1021/jm300682j
	CHEMBL2178569	82564	None	0	Human	Binding	pKi	=	8.9	8.9	-1	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	518	5	2	5	5.6	CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O	10.1021/jm300682j
	44337326	7966	None	0	Human	Binding	pKi	=	8.9	8.9	-1	3	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	600	7	0	5	6.4	COc1ccc(S(=O)(=O)c2ccc(CC3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)cc2)cc1	10.1021/jm0200815
	CHEMBL109051	7966	None	0	Human	Binding	pKi	=	8.9	8.9	-1	3	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	600	7	0	5	6.4	COc1ccc(S(=O)(=O)c2ccc(CC3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)cc2)cc1	10.1021/jm0200815
	174174	523	None	49	Human	Binding	pKi	=	8.9	8.9	-7	14	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	260	523	None	49	Human	Binding	pKi	=	8.9	8.9	-7	14	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	320	523	None	49	Human	Binding	pKi	=	8.9	8.9	-7	14	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.9	8.9	-7	14	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	DB00572	523	None	49	Human	Binding	pKi	=	8.9	8.9	-7	14	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	156015153	178305	None	0	Human	Binding	pKi	=	8.9	8.9	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178305	None	0	Human	Binding	pKi	=	8.9	8.9	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178305	None	0	Human	Binding	pKi	=	8.9	8.9	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	118719922	115773	None	0	Human	Binding	pKi	=	8.9	8.9	-1	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	565	14	0	7	6.1	CN1CCC=C(c2nsnc2OCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354068	115773	None	0	Human	Binding	pKi	=	8.9	8.9	-1	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	565	14	0	7	6.1	CN1CCC=C(c2nsnc2OCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	44343900	10510	None	0	Rat	Binding	pKi	=	8.9	8.9	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL116781	10510	None	0	Rat	Binding	pKi	=	8.9	8.9	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	59291527	112461	None	1	Rat	Binding	pKi	=	8.9	8.9	-11	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1sccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298333	112461	None	1	Rat	Binding	pKi	=	8.9	8.9	-11	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1sccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL5281043	194097	None	0	Human	Binding	pKi	=	8.9	8.9	-17	3	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	479	10	2	4	6.1	NCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	155530273	176349	None	0	Human	Binding	pKi	=	8.9	8.9	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
	CHEMBL4463636	176349	None	0	Human	Binding	pKi	=	8.9	8.9	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
	CHEMBL4595649	176349	None	0	Human	Binding	pKi	=	8.9	8.9	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
	156014880	178229	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636351	178229	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650536	178229	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	174174	523	None	49	Human	Binding	pKi	=	8.8	8.8	-7	14	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
	260	523	None	49	Human	Binding	pKi	=	8.8	8.8	-7	14	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
	320	523	None	49	Human	Binding	pKi	=	8.8	8.8	-7	14	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.8	8.8	-7	14	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
	DB00572	523	None	49	Human	Binding	pKi	=	8.8	8.8	-7	14	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
	44311716	165130	None	0	Human	Binding	pKi	=	8.8	8.8	22	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL422770	165130	None	0	Human	Binding	pKi	=	8.8	8.8	22	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311716	165130	None	0	Human	Binding	pKi	=	8.8	8.8	22	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL422770	165130	None	0	Human	Binding	pKi	=	8.8	8.8	22	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	174174	523	None	49	Rat	Binding	pKi	=	8.8	8.8	-4	14	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
	260	523	None	49	Rat	Binding	pKi	=	8.8	8.8	-4	14	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
	320	523	None	49	Rat	Binding	pKi	=	8.8	8.8	-4	14	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
	CHEMBL517712	523	None	49	Rat	Binding	pKi	=	8.8	8.8	-4	14	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
	DB00572	523	None	49	Rat	Binding	pKi	=	8.8	8.8	-4	14	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
	16115943	11845	None	0	Human	Binding	pKi	=	8.8	8.8	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1182205	11845	None	0	Human	Binding	pKi	=	8.8	8.8	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL220393	11845	None	0	Human	Binding	pKi	=	8.8	8.8	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	155560140	176345	None	0	Human	Binding	pKi	=	8.8	8.8	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4565234	176345	None	0	Human	Binding	pKi	=	8.8	8.8	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595575	176345	None	0	Human	Binding	pKi	=	8.8	8.8	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	174174	523	None	49	Human	Binding	pKi	=	8.8	8.8	-7	14	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
	260	523	None	49	Human	Binding	pKi	=	8.8	8.8	-7	14	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
	320	523	None	49	Human	Binding	pKi	=	8.8	8.8	-7	14	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.8	8.8	-7	14	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
	DB00572	523	None	49	Human	Binding	pKi	=	8.8	8.8	-7	14	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
	44343735	11088	None	1	Rat	Binding	pKi	=	8.8	8.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL117797	11088	None	1	Rat	Binding	pKi	=	8.8	8.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	44378807	58148	None	0	Rat	Binding	pKi	=	8.8	8.8	-	1	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	255	4	0	5	2.8	CCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
	CHEMBL167932	58148	None	0	Rat	Binding	pKi	=	8.8	8.8	-	1	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	255	4	0	5	2.8	CCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
	4134	72684	None	12	Human	Binding	pKi	=	8.8	8.8	1	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL1996652	72684	None	12	Human	Binding	pKi	=	8.8	8.8	1	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL2106570	72684	None	12	Human	Binding	pKi	=	8.8	8.8	1	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	10269503	167078	None	0	Human	Binding	pKi	=	8.8	8.8	-7	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL428962	167078	None	0	Human	Binding	pKi	=	8.8	8.8	-7	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	14939896	82085	None	0	Rat	Binding	pKi	=	8.8	8.8	-1	3	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201996	82085	None	0	Rat	Binding	pKi	=	8.8	8.8	-1	3	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216566	82085	None	0	Rat	Binding	pKi	=	8.8	8.8	-1	3	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10096939	164818	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]ccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL421864	164818	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]ccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44295932	189343	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL51256	189343	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	44344156	10127	None	0	Rat	Binding	pKi	=	8.8	8.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	624	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL115681	10127	None	0	Rat	Binding	pKi	=	8.8	8.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	624	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	9807612	59070	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL169565	59070	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	44383342	59482	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	548	6	0	7	4.4	O=C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL171411	59482	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	548	6	0	7	4.4	O=C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	16065135	67923	None	0	Human	Binding	pKi	=	8.8	8.8	-2	2	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@H](Oc2ccccc2)C1	10.1021/jm200884j
	CHEMBL1910846	67923	None	0	Human	Binding	pKi	=	8.8	8.8	-2	2	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@H](Oc2ccccc2)C1	10.1021/jm200884j
	11693	1825	None	16	Human	Binding	pKi	=	8.8	8.8	-2	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	3494	1825	None	16	Human	Binding	pKi	=	8.8	8.8	-2	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	4302	1825	None	16	Human	Binding	pKi	=	8.8	8.8	-2	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	7459	1825	None	16	Human	Binding	pKi	=	8.8	8.8	-2	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	9933193	1825	None	16	Human	Binding	pKi	=	8.8	8.8	-2	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	CHEMBL1201335	1825	None	16	Human	Binding	pKi	=	8.8	8.8	-2	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	DB00986	1825	None	16	Human	Binding	pKi	=	8.8	8.8	-2	5	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	140844401	176685	None	0	Human	Binding	pKi	=	8.8	8.8	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4539799	176685	None	0	Human	Binding	pKi	=	8.8	8.8	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4598363	176685	None	0	Human	Binding	pKi	=	8.8	8.8	1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	174174	523	None	49	Rat	Binding	pKi	=	8.8	8.8	-4	14	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	260	523	None	49	Rat	Binding	pKi	=	8.8	8.8	-4	14	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	320	523	None	49	Rat	Binding	pKi	=	8.8	8.8	-4	14	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	CHEMBL517712	523	None	49	Rat	Binding	pKi	=	8.8	8.8	-4	14	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	DB00572	523	None	49	Rat	Binding	pKi	=	8.8	8.8	-4	14	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	16125541	137205	None	0	Human	Binding	pKi	=	8.8	8.8	1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL374989	137205	None	0	Human	Binding	pKi	=	8.8	8.8	1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	155513986	176485	None	0	Human	Binding	pKi	=	8.8	8.8	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4439675	176485	None	0	Human	Binding	pKi	=	8.8	8.8	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596667	176485	None	0	Human	Binding	pKi	=	8.8	8.8	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	101882890	115774	None	0	Human	Binding	pKi	=	8.8	8.8	-1	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	593	16	0	7	6.8	CN1CCC=C(c2nsnc2OCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354069	115774	None	0	Human	Binding	pKi	=	8.8	8.8	-1	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	593	16	0	7	6.8	CN1CCC=C(c2nsnc2OCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	14939894	10294	None	0	Rat	Binding	pKi	=	8.8	8.8	1	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL116172	10294	None	0	Rat	Binding	pKi	=	8.8	8.8	1	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	302	2975	None	25	Mouse	Binding	pKi	=	8.8	8.8	-3	8	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	4630	2975	None	25	Mouse	Binding	pKi	=	8.8	8.8	-3	8	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	CHEMBL7634	2975	None	25	Mouse	Binding	pKi	=	8.8	8.8	-3	8	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	CHEMBL5284000	194237	None	0	Human	Binding	pKi	=	8.8	8.8	-6	3	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	493	11	2	4	6.6	NCCCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	71128	96808	None	25	Rat	Binding	pKi	=	8.8	8.8	-3	8	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	CHEMBL26505	96808	None	25	Rat	Binding	pKi	=	8.8	8.8	-3	8	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	14210083	156710	None	1	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	CHEMBL4070155	156710	None	1	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	44378763	120501	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	613	6	0	5	6.2	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4cccc(C(F)(F)F)c4)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL354461	120501	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	613	6	0	5	6.2	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4cccc(C(F)(F)F)c4)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	44344215	13279	None	0	Rat	Binding	pKi	=	8.7	8.7	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	668	7	0	7	5.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Br)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL119168	13279	None	0	Rat	Binding	pKi	=	8.7	8.7	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	668	7	0	7	5.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Br)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	16721019	87984	None	0	Human	Binding	pKi	=	8.7	8.7	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234258	87984	None	0	Human	Binding	pKi	=	8.7	8.7	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	10061124	78904	None	0	Rat	Binding	pKi	=	8.7	8.7	-	1	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	259	4	0	5	2.3	CN1CCC=C(c2nsnc2SCCF)C1	10.1021/jm00001a002
	CHEMBL2112938	78904	None	0	Rat	Binding	pKi	=	8.7	8.7	-	1	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	259	4	0	5	2.3	CN1CCC=C(c2nsnc2SCCF)C1	10.1021/jm00001a002
	44324891	111562	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@@H](C)[C@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328093	111562	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@@H](C)[C@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	155559741	176285	None	0	Human	Binding	pKi	=	8.7	8.7	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4562770	176285	None	0	Human	Binding	pKi	=	8.7	8.7	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595125	176285	None	0	Human	Binding	pKi	=	8.7	8.7	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	444015	14014	None	1	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL1197177	14014	None	1	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	44295617	189647	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL51510	189647	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	44431389	146149	None	0	Human	Binding	pKi	=	8.7	8.7	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL391977	146149	None	0	Human	Binding	pKi	=	8.7	8.7	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	174174	523	None	49	Human	Binding	pKi	=	8.7	8.7	-7	14	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
	260	523	None	49	Human	Binding	pKi	=	8.7	8.7	-7	14	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
	320	523	None	49	Human	Binding	pKi	=	8.7	8.7	-7	14	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.7	8.7	-7	14	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
	DB00572	523	None	49	Human	Binding	pKi	=	8.7	8.7	-7	14	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
	59291421	112775	None	0	Rat	Binding	pKi	=	8.7	8.7	-2	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298592	112775	None	0	Rat	Binding	pKi	=	8.7	8.7	-2	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305620	112775	None	0	Rat	Binding	pKi	=	8.7	8.7	-2	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	164609302	188461	None	0	Human	Binding	pKi	=	8.7	8.7	20	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4846958	188461	None	0	Human	Binding	pKi	=	8.7	8.7	20	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5027951	188461	None	0	Human	Binding	pKi	=	8.7	8.7	20	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	14210083	156710	None	1	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4070155	156710	None	1	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
	324	1923	None	15	Human	Binding	pKi	=	8	8.0	-1	9	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
	6436265	1923	None	15	Human	Binding	pKi	=	8	8.0	-1	9	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
	CHEMBL277642	1923	None	15	Human	Binding	pKi	=	8	8.0	-1	9	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
	324	1923	None	15	Human	Binding	pKi	=	8	8.0	-1	9	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	6436265	1923	None	15	Human	Binding	pKi	=	8	8.0	-1	9	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	CHEMBL277642	1923	None	15	Human	Binding	pKi	=	8	8.0	-1	9	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	324	1923	None	15	Rat	Binding	pKi	=	8	8.0	-1	9	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
	6436265	1923	None	15	Rat	Binding	pKi	=	8	8.0	-1	9	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
	CHEMBL277642	1923	None	15	Rat	Binding	pKi	=	8	8.0	-1	9	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
	10104167	2057	None	2	Human	Binding	pKi	=	8	8.0	13	4	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	6937	2057	None	2	Human	Binding	pKi	=	8	8.0	13	4	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	CHEMBL3121473	2057	None	2	Human	Binding	pKi	=	8	8.0	13	4	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	44627746	14040	None	0	Human	Binding	pKi	=	8.0	8.0	-4	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197392	14040	None	0	Human	Binding	pKi	=	8.0	8.0	-4	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569760	14040	None	0	Human	Binding	pKi	=	8.0	8.0	-4	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	122203596	155804	None	0	Human	Binding	pKi	=	8.0	8.0	1	5	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155804	None	0	Human	Binding	pKi	=	8.0	8.0	1	5	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155804	None	0	Human	Binding	pKi	=	8.0	8.0	1	5	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	52941205	55267	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
	CHEMBL1256938	55267	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
	CHEMBL1618160	55267	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
	23724781	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	316	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	317	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	71183	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	DB00462	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	156015246	178237	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4648144	178237	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650567	178237	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	71452793	79653	None	0	Human	Binding	pKi	=	8.0	8.0	1	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2115127	79653	None	0	Human	Binding	pKi	=	8.0	8.0	1	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	444015	14014	None	1	Human	Binding	pKi	=	8.0	8.0	-	1	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL1197177	14014	None	1	Human	Binding	pKi	=	8.0	8.0	-	1	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	118719921	115772	None	0	Human	Binding	pKi	=	8.0	8.0	-2	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	537	12	0	7	5.3	CN1CCC=C(c2nsnc2OCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354067	115772	None	0	Human	Binding	pKi	=	8.0	8.0	-2	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	537	12	0	7	5.3	CN1CCC=C(c2nsnc2OCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	455657	204003	None	1	Human	Binding	pKi	=	7	7.0	-3	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	624	6	1	8	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(N)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	CHEMBL69642	204003	None	1	Human	Binding	pKi	=	7	7.0	-3	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	624	6	1	8	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(N)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	455656	204008	None	1	Human	Binding	pKi	=	7	7.0	-3	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	604	6	1	8	4.5	Cc1cccc(N)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL69670	204008	None	1	Human	Binding	pKi	=	7	7.0	-3	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	604	6	1	8	4.5	Cc1cccc(N)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	24841480	183897	None	0	Human	Binding	pKi	=	7	7.0	-50	20	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL481153	183897	None	0	Human	Binding	pKi	=	7	7.0	-50	20	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	135398737	957	None	93	Human	Binding	pKi	=	7	7.0	-22	91	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	38	957	None	93	Human	Binding	pKi	=	7	7.0	-22	91	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	722	957	None	93	Human	Binding	pKi	=	7	7.0	-22	91	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	CHEMBL42	957	None	93	Human	Binding	pKi	=	7	7.0	-22	91	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	DB00363	957	None	93	Human	Binding	pKi	=	7	7.0	-22	91	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	135398745	2912	None	112	Human	Binding	pKi	=	7	7.0	-38	66	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	47	2912	None	112	Human	Binding	pKi	=	7	7.0	-38	66	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	CHEMBL715	2912	None	112	Human	Binding	pKi	=	7	7.0	-38	66	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	DB00334	2912	None	112	Human	Binding	pKi	=	7	7.0	-38	66	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	44406527	140647	None	0	Human	Binding	pKi	=	7	7.0	-1	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	CO[C@]1(C#CC(O)(c2cccnc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381469	140647	None	0	Human	Binding	pKi	=	7	7.0	-1	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	CO[C@]1(C#CC(O)(c2cccnc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	2551	793	None	23	Human	Binding	pKi	=	7	7.0	-6	11	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	298	793	None	23	Human	Binding	pKi	=	7	7.0	-6	11	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	488	793	None	23	Human	Binding	pKi	=	7	7.0	-6	11	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	CHEMBL965	793	None	23	Human	Binding	pKi	=	7	7.0	-6	11	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	DB00411	793	None	23	Human	Binding	pKi	=	7	7.0	-6	11	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	46855274	113716	None	12	Human	Binding	pKi	=	7	7.0	-	1	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	182	2	0	4	0.3	CN(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323285	113716	None	12	Human	Binding	pKi	=	7	7.0	-	1	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	182	2	0	4	0.3	CN(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	155536739	172213	None	0	Human	Binding	pKi	=	7	7.0	-2	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	384	5	0	4	4.1	COc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
	CHEMBL4473985	172213	None	0	Human	Binding	pKi	=	7	7.0	-2	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	384	5	0	4	4.1	COc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
	44385509	61061	None	11	Rat	Binding	pKi	=	7	7.0	-3	2	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	270	4	0	3	1.6	CCN(CC)CC#CCN1C(=O)c2ccccc2C1=O	10.1016/S0960-894X(97)00143-1
	CHEMBL176400	61061	None	11	Rat	Binding	pKi	=	7	7.0	-3	2	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	270	4	0	3	1.6	CCN(CC)CC#CCN1C(=O)c2ccccc2C1=O	10.1016/S0960-894X(97)00143-1
	2551	793	None	23	Human	Binding	pKi	=	7	7.0	-6	11	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	298	793	None	23	Human	Binding	pKi	=	7	7.0	-6	11	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	488	793	None	23	Human	Binding	pKi	=	7	7.0	-6	11	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	CHEMBL965	793	None	23	Human	Binding	pKi	=	7	7.0	-6	11	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	DB00411	793	None	23	Human	Binding	pKi	=	7	7.0	-6	11	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	16086067	81315	None	0	Human	Binding	pKi	=	7	7.0	-63	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	CHEMBL215894	81315	None	0	Human	Binding	pKi	=	7	7.0	-63	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	10248403	103418	None	0	Rat	Binding	pKi	=	6	6.0	-25	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	367	6	0	4	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(OC)cc2)cc1	10.1021/jm00020a006
	CHEMBL3084867	103418	None	0	Rat	Binding	pKi	=	6	6.0	-25	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	367	6	0	4	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(OC)cc2)cc1	10.1021/jm00020a006
	44309209	204321	None	0	Human	Binding	pKi	=	6	6.0	-38	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	5	2	3	3.7	CC(C)(N)CC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL71483	204321	None	0	Human	Binding	pKi	=	6	6.0	-38	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	5	2	3	3.7	CC(C)(N)CC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	301	2532	None	19	Human	Binding	pKi	=	6	6.0	3	5	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	9571002	2532	None	19	Human	Binding	pKi	=	6	6.0	3	5	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	CHEMBL151938	2532	None	19	Human	Binding	pKi	=	6	6.0	3	5	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	118500	156997	None	63	Human	Binding	pKi	=	6	6.0	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4073256	156997	None	63	Human	Binding	pKi	=	6	6.0	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	25147647	182137	None	0	Human	Binding	pKi	=	6	6.0	2	3	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@H]21	10.1016/j.bmc.2008.06.025
	CHEMBL478226	182137	None	0	Human	Binding	pKi	=	6	6.0	2	3	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@H]21	10.1016/j.bmc.2008.06.025
	11798126	41970	None	0	Human	Binding	pKi	=	6	6.0	-288	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	2	4	4.1	COc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	CHEMBL149484	41970	None	0	Human	Binding	pKi	=	6	6.0	-288	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	2	4	4.1	COc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	137630848	161114	None	0	Human	Binding	pKi	=	5	5.0	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4061390	161114	None	0	Human	Binding	pKi	=	5	5.0	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117131	161114	None	0	Human	Binding	pKi	=	5	5.0	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	302	2975	None	25	Human	Binding	pKi	=	5	5.0	-34	8	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	4630	2975	None	25	Human	Binding	pKi	=	5	5.0	-34	8	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	CHEMBL7634	2975	None	25	Human	Binding	pKi	=	5	5.0	-34	8	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	302	2975	None	25	Human	Binding	pKi	=	5	5.0	-34	8	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	4630	2975	None	25	Human	Binding	pKi	=	5	5.0	-34	8	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	CHEMBL7634	2975	None	25	Human	Binding	pKi	=	5	5.0	-34	8	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	56593934	65693	None	0	Human	Binding	pKi	=	5	5.0	-2630	8	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	383	3	2	4	1.7	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC2(C=N1)CCNCC2	10.1021/jm200466r
	CHEMBL1834350	65693	None	0	Human	Binding	pKi	=	5	5.0	-2630	8	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	383	3	2	4	1.7	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC2(C=N1)CCNCC2	10.1021/jm200466r
	73352414	92530	None	0	Human	Binding	pKi	=	6	6.0	-1	5	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	257	3	1	1	3.3	C1CCC(CN[C@H]2C3C4CC5C6C4CC3C6C52)CC1	10.1016/j.bmc.2013.07.045
	CHEMBL2432038	92530	None	0	Human	Binding	pKi	=	6	6.0	-1	5	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	257	3	1	1	3.3	C1CCC(CN[C@H]2C3C4CC5C6C4CC3C6C52)CC1	10.1016/j.bmc.2013.07.045
	16125648	84733	None	0	Human	Binding	pKi	=	6.0	6.0	-44	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2cccnc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222874	84733	None	0	Human	Binding	pKi	=	6.0	6.0	-44	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2cccnc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	15065550	205115	None	2	Human	Binding	pKi	=	7.0	7.0	-1	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	2	0	3	0.8	Cc1nccn1CC#CCN1CCCC1=O	10.1016/j.bmc.2007.12.036
	CHEMBL77793	205115	None	2	Human	Binding	pKi	=	7.0	7.0	-1	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	2	0	3	0.8	Cc1nccn1CC#CCN1CCCC1=O	10.1016/j.bmc.2007.12.036
	72064	78399	None	14	Human	Binding	pKi	=	6.0	6.0	-2	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	10.1016/j.bmc.2013.01.072
	CHEMBL2110892	78399	None	14	Human	Binding	pKi	=	6.0	6.0	-2	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	10.1016/j.bmc.2013.01.072
	11131099	120259	None	0	Human	Binding	pKi	=	6.0	6.0	3	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	CHEMBL352404	120259	None	0	Human	Binding	pKi	=	6.0	6.0	3	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	302	2975	None	25	Human	Binding	pKi	=	6.0	6.0	-34	8	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	4630	2975	None	25	Human	Binding	pKi	=	6.0	6.0	-34	8	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	CHEMBL7634	2975	None	25	Human	Binding	pKi	=	6.0	6.0	-34	8	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	44593619	187458	None	0	Human	Binding	pKi	=	6.0	6.0	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493980	187458	None	0	Human	Binding	pKi	=	6.0	6.0	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	73346334	92539	None	0	Human	Binding	pKi	=	6.0	6.0	-1	7	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	4	1	1	3.0	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)cc1	10.1016/j.bmc.2013.07.045
	CHEMBL2432048	92539	None	0	Human	Binding	pKi	=	6.0	6.0	-1	7	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	4	1	1	3.0	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)cc1	10.1016/j.bmc.2013.07.045
	44295616	188791	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	549	6	1	3	6.8	O=C(Nc1ccccc1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL50584	188791	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	549	6	1	3	6.8	O=C(Nc1ccccc1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44267766	161317	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	CHEMBL412421	161317	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	44267766	161317	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1021/jm0255163
	CHEMBL412421	161317	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1021/jm0255163
	134688371	14427	None	10	Human	Binding	pKi	=	7.0	7.0	-	1	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	13765	14427	None	10	Human	Binding	pKi	=	7.0	7.0	-	1	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	CHEMBL1200623	14427	None	10	Human	Binding	pKi	=	7.0	7.0	-	1	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	164621085	188547	None	0	Human	Binding	pKi	=	7.0	7.0	16	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4869980	188547	None	0	Human	Binding	pKi	=	7.0	7.0	16	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028630	188547	None	0	Human	Binding	pKi	=	7.0	7.0	16	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	639794	98767	None	1	Human	Binding	pKi	=	5.0	5.0	1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL278129	98767	None	1	Human	Binding	pKi	=	5.0	5.0	1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	3652	46242	None	70	Human	Binding	pKi	=	6.0	6.0	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
	CHEMBL1535	46242	None	70	Human	Binding	pKi	=	6.0	6.0	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
	44400175	67767	None	0	Rat	Binding	pKi	=	7.0	7.0	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	307	5	1	2	4.2	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	CHEMBL190815	67767	None	0	Rat	Binding	pKi	=	7.0	7.0	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	307	5	1	2	4.2	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	44295878	191788	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	475	5	1	3	5.1	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL51982	191788	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	475	5	1	3	5.1	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	71128	96808	None	25	Human	Binding	pKi	=	7.0	7.0	-17	8	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL26505	96808	None	25	Human	Binding	pKi	=	7.0	7.0	-17	8	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	16124706	137520	None	0	Human	Binding	pKi	=	7.0	7.0	-61	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	4	5.1	Cc1cccc(CN2CCC(N3CC(c4cccs4)(c4cccs4)NC3=O)CC2)c1	10.1021/jm061159a
	CHEMBL375420	137520	None	0	Human	Binding	pKi	=	7.0	7.0	-61	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	4	5.1	Cc1cccc(CN2CCC(N3CC(c4cccs4)(c4cccs4)NC3=O)CC2)c1	10.1021/jm061159a
	303	2976	None	17	Human	Binding	pKi	=	7.0	7.0	-1	6	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	4629	2976	None	17	Human	Binding	pKi	=	7.0	7.0	-1	6	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	8595	2976	None	17	Human	Binding	pKi	=	7.0	7.0	-1	6	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	CHEMBL44674	2976	None	17	Human	Binding	pKi	=	7.0	7.0	-1	6	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	10871551	120509	None	0	Human	Binding	pKi	=	7.0	7.0	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	340	6	0	2	5.2	CCC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL354523	120509	None	0	Human	Binding	pKi	=	7.0	7.0	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	340	6	0	2	5.2	CCC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
	44593618	187457	None	0	Human	Binding	pKi	=	7.0	7.0	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493979	187457	None	0	Human	Binding	pKi	=	7.0	7.0	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	71718669	86956	None	0	Rat	Binding	pKi	=	5.0	5.0	-8	3	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323446	86956	None	0	Rat	Binding	pKi	=	5.0	5.0	-8	3	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	11012712	57827	None	2	Human	Binding	pKi	=	6.0	6.0	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
	CHEMBL167027	57827	None	2	Human	Binding	pKi	=	6.0	6.0	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
	167962	4067	None	4	Human	Binding	pKi	=	6.0	6.0	-	1	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4067	None	4	Human	Binding	pKi	=	6.0	6.0	-	1	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4067	None	4	Human	Binding	pKi	=	6.0	6.0	-	1	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	9931930	108598	None	0	Human	Binding	pKi	=	6.0	6.0	-537	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.8	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL320465	108598	None	0	Human	Binding	pKi	=	6.0	6.0	-537	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.8	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	11079969	163855	None	0	Human	Binding	pKi	=	6.0	6.0	-70	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	404	4	1	5	4.3	C=CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL420662	163855	None	0	Human	Binding	pKi	=	6.0	6.0	-70	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	404	4	1	5	4.3	C=CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	44267713	15603	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	466	7	0	4	5.8	COc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12215	15603	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	466	7	0	4	5.8	COc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	16125400	84661	None	0	Human	Binding	pKi	=	7.0	7.0	-35	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222449	84661	None	0	Human	Binding	pKi	=	7.0	7.0	-35	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	71456286	79596	None	0	Rat	Binding	pKi	=	5.0	5.0	-1	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL2114430	79596	None	0	Rat	Binding	pKi	=	5.0	5.0	-1	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	10380647	154432	None	1	Rat	Binding	pKi	=	5.0	5.0	-1	2	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	309	2	0	2	4.8	c1ccc(CN2CCC3(CCc4ccccc4S3)CC2)cc1	10.1021/jm970740r
	CHEMBL39900	154432	None	1	Rat	Binding	pKi	=	5.0	5.0	-1	2	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	309	2	0	2	4.8	c1ccc(CN2CCC3(CCc4ccccc4S3)CC2)cc1	10.1021/jm970740r
	15050949	203974	None	0	Rat	Binding	pKi	=	6.0	6.0	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	641	10	3	8	4.2	CC(C)(C)OC(=O)NCCCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	CHEMBL69458	203974	None	0	Rat	Binding	pKi	=	6.0	6.0	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	641	10	3	8	4.2	CC(C)(C)OC(=O)NCCCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	11498	3017	None	41	Human	Binding	pKi	=	6.0	6.0	-67	6	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
	4995951	3017	None	41	Human	Binding	pKi	=	6.0	6.0	-67	6	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
	CHEMBL59898	3017	None	41	Human	Binding	pKi	=	6.0	6.0	-67	6	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
	15888011	204311	None	0	Human	Binding	pKi	=	8.0	8.0	-11	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	302	3	2	3	2.0	NC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL71431	204311	None	0	Human	Binding	pKi	=	8.0	8.0	-11	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	302	3	2	3	2.0	NC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	44267718	17011	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4nccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12542	17011	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4nccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL5285607	194302	None	0	Human	Binding	pKi	=	8.0	8.0	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1052	21	1	13	10.0	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
	155521383	176424	None	0	Human	Binding	pKi	=	8.0	8.0	8	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4450522	176424	None	0	Human	Binding	pKi	=	8.0	8.0	8	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596184	176424	None	0	Human	Binding	pKi	=	8.0	8.0	8	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	71741394	120833	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323287	120833	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558239	120833	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	10474247	101402	None	0	Rat	Binding	pKi	=	7.9	7.9	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	CHEMBL297276	101402	None	0	Rat	Binding	pKi	=	7.9	7.9	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	15678852	102215	None	0	Rat	Binding	pKi	=	7.9	7.9	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	492	12	2	6	4.0	NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL302923	102215	None	0	Rat	Binding	pKi	=	7.9	7.9	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	492	12	2	6	4.0	NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	3652	4095	None	79	Human	Binding	pKi	=	7.9	7.9	-18	18	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	57	4095	None	79	Human	Binding	pKi	=	7.9	7.9	-18	18	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	60809	4095	None	79	Human	Binding	pKi	=	7.9	7.9	-18	18	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	7.9	7.9	-18	18	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	DB15357	4095	None	79	Human	Binding	pKi	=	7.9	7.9	-18	18	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	2028	2977	None	80	Human	Binding	pKi	=	7.9	7.9	-8	11	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
	359	2977	None	80	Human	Binding	pKi	=	7.9	7.9	-8	11	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
	4634	2977	None	80	Human	Binding	pKi	=	7.9	7.9	-8	11	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
	CHEMBL1231	2977	None	80	Human	Binding	pKi	=	7.9	7.9	-8	11	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
	DB01062	2977	None	80	Human	Binding	pKi	=	7.9	7.9	-8	11	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
	14964495	12611	None	1	Rat	Binding	pKi	=	7.0	7.0	4	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118700	12611	None	1	Rat	Binding	pKi	=	7.0	7.0	4	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	11526446	201802	None	0	Rat	Binding	pKi	=	7.0	7.0	-13	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccsc1	10.1021/jm050099q
	CHEMBL606904	201802	None	0	Rat	Binding	pKi	=	7.0	7.0	-13	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccsc1	10.1021/jm050099q
	16086064	79958	None	0	Human	Binding	pKi	=	7.0	7.0	-213	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	10	2	5	5.6	O=C(NCC1CCN(C2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL212645	79958	None	0	Human	Binding	pKi	=	7.0	7.0	-213	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	10	2	5	5.6	O=C(NCC1CCN(C2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	5747382	109201	None	3	Mouse	Binding	pKi	=	6.0	6.0	-	1	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL321605	109201	None	3	Mouse	Binding	pKi	=	6.0	6.0	-	1	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	44309208	165647	None	0	Human	Binding	pKi	=	6.0	6.0	-77	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.1	O=C(N1CCCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL424416	165647	None	0	Human	Binding	pKi	=	6.0	6.0	-77	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.1	O=C(N1CCCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	14964496	8962	None	0	Rat	Binding	pKi	=	6.0	6.0	1	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL109815	8962	None	0	Rat	Binding	pKi	=	6.0	6.0	1	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	10339062	36285	None	0	Human	Binding	pKi	=	6.0	6.0	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	1	3.4	C[N+]12CCC(CC1)C(c1cc3ccccc3o1)C2	10.1021/jm00003a011
	CHEMBL144580	36285	None	0	Human	Binding	pKi	=	6.0	6.0	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	1	3.4	C[N+]12CCC(CC1)C(c1cc3ccccc3o1)C2	10.1021/jm00003a011
	474188	31647	None	2	Human	Binding	pKi	=	6.0	6.0	-28	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	1	6	4.5	Cc1nc(N)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL140490	31647	None	2	Human	Binding	pKi	=	6.0	6.0	-28	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	1	6	4.5	Cc1nc(N)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	10595006	11443	None	0	Human	Binding	pKi	=	6.0	6.0	-6	5	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	CHEMBL1180343	11443	None	0	Human	Binding	pKi	=	6.0	6.0	-6	5	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	CHEMBL123099	11443	None	0	Human	Binding	pKi	=	6.0	6.0	-6	5	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	53414666	159299	None	8	Human	Binding	pKi	=	5.0	5.0	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4099673	159299	None	8	Human	Binding	pKi	=	5.0	5.0	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	574782	102149	None	2	Rat	Binding	pKi	=	5.0	5.0	-3	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	397	3	1	6	2.3	CSc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCN(C)CC1	10.1021/jm00111a032
	CHEMBL302557	102149	None	2	Rat	Binding	pKi	=	5.0	5.0	-3	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	397	3	1	6	2.3	CSc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCN(C)CC1	10.1021/jm00111a032
	2274	3171	None	58	Human	Binding	pKi	=	6.0	6.0	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	4917	3171	None	58	Human	Binding	pKi	=	6.0	6.0	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	7279	3171	None	58	Human	Binding	pKi	=	6.0	6.0	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	CHEMBL728	3171	None	58	Human	Binding	pKi	=	6.0	6.0	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	DB00433	3171	None	58	Human	Binding	pKi	=	6.0	6.0	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	44379508	58162	None	0	Human	Binding	pKi	=	7.0	7.0	-3	3	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	664	9	1	4	6.6	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1cccc(I)c1	10.1016/S0960-894X(97)00109-1
	CHEMBL168145	58162	None	0	Human	Binding	pKi	=	7.0	7.0	-3	3	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	664	9	1	4	6.6	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1cccc(I)c1	10.1016/S0960-894X(97)00109-1
	11034265	120371	None	0	Human	Binding	pKi	=	7.0	7.0	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	310	5	0	2	4.3	CC(C1=C(CCN(C)C)Cc2ccc(F)cc21)c1ccccn1	10.1021/jm020895l
	CHEMBL353290	120371	None	0	Human	Binding	pKi	=	7.0	7.0	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	310	5	0	2	4.3	CC(C1=C(CCN(C)C)Cc2ccc(F)cc21)c1ccccn1	10.1021/jm020895l
	162353386	180978	None	0	Human	Binding	pKi	=	6.0	6.0	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758635	180978	None	0	Human	Binding	pKi	=	6.0	6.0	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	46227555	14129	None	1	Human	Binding	pKi	=	5.0	5.0	5	4	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL1198062	14129	None	1	Human	Binding	pKi	=	5.0	5.0	5	4	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL594376	14129	None	1	Human	Binding	pKi	=	5.0	5.0	5	4	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	44443734	94237	None	0	Rat	Binding	pKi	=	5.9	5.9	-16	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL250031	94237	None	0	Rat	Binding	pKi	=	5.9	5.9	-16	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	36014865	182668	None	2	Human	Binding	pKi	=	6.9	6.9	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	CHEMBL4789054	182668	None	2	Human	Binding	pKi	=	6.9	6.9	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	16125682	84287	None	0	Human	Binding	pKi	=	5.9	5.9	-239	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	465	5	1	2	5.0	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	CHEMBL221401	84287	None	0	Human	Binding	pKi	=	5.9	5.9	-239	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	465	5	1	2	5.0	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	44299635	100567	None	0	Human	Binding	pKi	=	5.9	5.9	1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL291562	100567	None	0	Human	Binding	pKi	=	5.9	5.9	1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	164623185	188568	None	0	Human	Binding	pKi	=	5.9	5.9	-1	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4864101	188568	None	0	Human	Binding	pKi	=	5.9	5.9	-1	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028743	188568	None	0	Human	Binding	pKi	=	5.9	5.9	-1	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	137640511	157064	None	0	Human	Binding	pKi	=	4.9	4.9	-44	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	286	4	0	2	3.1	CC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4074104	157064	None	0	Human	Binding	pKi	=	4.9	4.9	-44	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	286	4	0	2	3.1	CC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	16125593	84739	None	0	Human	Binding	pKi	=	5.9	5.9	-2	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	467	8	1	3	4.1	N#CC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222916	84739	None	0	Human	Binding	pKi	=	5.9	5.9	-2	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	467	8	1	3	4.1	N#CC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	3198	205511	None	76	Human	Binding	pKi	=	5.9	5.9	-16	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205511	None	76	Human	Binding	pKi	=	5.9	5.9	-16	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205511	None	76	Human	Binding	pKi	=	5.9	5.9	-16	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	73345823	89813	None	0	Human	Binding	pKi	=	6.9	6.9	-19	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	305	10	0	3	4.1	CC[C@H](C)C(C(=O)OCCCN(CC)CC)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL2377392	89813	None	0	Human	Binding	pKi	=	6.9	6.9	-19	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	305	10	0	3	4.1	CC[C@H](C)C(C(=O)OCCCN(CC)CC)c1ccccc1	10.1016/j.bmc.2013.01.072
	11722587	12934	None	0	Rat	Binding	pKi	=	6.9	6.9	-5	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1189204	12934	None	0	Rat	Binding	pKi	=	6.9	6.9	-5	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL538266	12934	None	0	Rat	Binding	pKi	=	6.9	6.9	-5	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
	26987	948	None	33	Human	Binding	pKi	=	6.9	6.9	-102	21	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
	6063	948	None	33	Human	Binding	pKi	=	6.9	6.9	-102	21	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
	671	948	None	33	Human	Binding	pKi	=	6.9	6.9	-102	21	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
	CHEMBL1626	948	None	33	Human	Binding	pKi	=	6.9	6.9	-102	21	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
	DB00283	948	None	33	Human	Binding	pKi	=	6.9	6.9	-102	21	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
	71575447	86200	None	0	Human	Binding	pKi	=	5.9	5.9	-19	5	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	363	5	0	4	3.5	CN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
	CHEMBL2312361	86200	None	0	Human	Binding	pKi	=	5.9	5.9	-19	5	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	363	5	0	4	3.5	CN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
	44299599	167803	None	0	Human	Binding	pKi	=	5.9	5.9	1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL430587	167803	None	0	Human	Binding	pKi	=	5.9	5.9	1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	44313166	103099	None	0	Human	Binding	pKi	=	5.9	5.9	2	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	415	7	0	5	4.0	O=C(OCOCCN1CCOCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	CHEMBL307628	103099	None	0	Human	Binding	pKi	=	5.9	5.9	2	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	415	7	0	5	4.0	O=C(OCOCCN1CCOCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	2337	3254	None	77	Human	Binding	pKi	=	5.9	5.9	-31	63	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	50	3254	None	77	Human	Binding	pKi	=	5.9	5.9	-31	63	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	5002	3254	None	77	Human	Binding	pKi	=	5.9	5.9	-31	63	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	CHEMBL716	3254	None	77	Human	Binding	pKi	=	5.9	5.9	-31	63	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	DB01224	3254	None	77	Human	Binding	pKi	=	5.9	5.9	-31	63	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	11061341	78917	None	0	Human	Binding	pKi	=	7.9	7.9	-25	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	662	13	2	4	6.3	O=C(CCNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL2112958	78917	None	0	Human	Binding	pKi	=	7.9	7.9	-25	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	662	13	2	4	6.3	O=C(CCNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	44295787	189084	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	481	6	1	3	5.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL50998	189084	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	481	6	1	3	5.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44267759	11748	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	529	7	0	4	5.6	CN(C)C(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11816	11748	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	529	7	0	4	5.6	CN(C)C(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	10163651	163231	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL418446	163231	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	15870389	120792	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2cccnc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL355510	120792	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2cccnc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	277	1300	None	62	Human	Binding	pKi	=	7.9	7.9	-12	50	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2913	1300	None	62	Human	Binding	pKi	=	7.9	7.9	-12	50	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	765	1300	None	62	Human	Binding	pKi	=	7.9	7.9	-12	50	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	CHEMBL516	1300	None	62	Human	Binding	pKi	=	7.9	7.9	-12	50	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	DB00434	1300	None	62	Human	Binding	pKi	=	7.9	7.9	-12	50	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2286	3181	None	51	Human	Binding	pKi	=	7.9	7.9	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	4927	3181	None	51	Human	Binding	pKi	=	7.9	7.9	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	7282	3181	None	51	Human	Binding	pKi	=	7.9	7.9	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	CHEMBL643	3181	None	51	Human	Binding	pKi	=	7.9	7.9	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	DB01069	3181	None	51	Human	Binding	pKi	=	7.9	7.9	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	2745	3859	None	42	Human	Binding	pKi	=	7.9	7.9	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	5572	3859	None	42	Human	Binding	pKi	=	7.9	7.9	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	66007	3859	None	42	Human	Binding	pKi	=	7.9	7.9	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	7315	3859	None	42	Human	Binding	pKi	=	7.9	7.9	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	CHEMBL1490	3859	None	42	Human	Binding	pKi	=	7.9	7.9	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	DB00376	3859	None	42	Human	Binding	pKi	=	7.9	7.9	-46	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	44431388	87317	None	0	Human	Binding	pKi	=	7.9	7.9	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL233202	87317	None	0	Human	Binding	pKi	=	7.9	7.9	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	44431380	87983	None	0	Human	Binding	pKi	=	7.9	7.9	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234257	87983	None	0	Human	Binding	pKi	=	7.9	7.9	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	16065136	67924	None	0	Human	Binding	pKi	=	7.9	7.9	-3	2	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@@H](Oc2ccccc2)C1	10.1021/jm200884j
	CHEMBL1910847	67924	None	0	Human	Binding	pKi	=	7.9	7.9	-3	2	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@@H](Oc2ccccc2)C1	10.1021/jm200884j
	140844418	176408	None	0	Human	Binding	pKi	=	7.9	7.9	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4576060	176408	None	0	Human	Binding	pKi	=	7.9	7.9	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596067	176408	None	0	Human	Binding	pKi	=	7.9	7.9	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	140844397	176596	None	0	Human	Binding	pKi	=	7.9	7.9	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4567385	176596	None	0	Human	Binding	pKi	=	7.9	7.9	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597612	176596	None	0	Human	Binding	pKi	=	7.9	7.9	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	140844405	176640	None	0	Human	Binding	pKi	=	7.9	7.9	-2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4474694	176640	None	0	Human	Binding	pKi	=	7.9	7.9	-2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597973	176640	None	0	Human	Binding	pKi	=	7.9	7.9	-2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	10316726	12026	None	0	Rat	Binding	pKi	=	7.9	7.9	-35	5	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	12026	None	0	Rat	Binding	pKi	=	7.9	7.9	-35	5	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	12026	None	0	Rat	Binding	pKi	=	7.9	7.9	-35	5	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	164614994	188500	None	0	Human	Binding	pKi	=	7.9	7.9	23	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4850553	188500	None	0	Human	Binding	pKi	=	7.9	7.9	23	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028287	188500	None	0	Human	Binding	pKi	=	7.9	7.9	23	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	155528270	176389	None	0	Human	Binding	pKi	=	7.9	7.9	7	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4461081	176389	None	0	Human	Binding	pKi	=	7.9	7.9	7	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595943	176389	None	0	Human	Binding	pKi	=	7.9	7.9	7	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	44325080	111569	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	588	8	0	7	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328120	111569	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	588	8	0	7	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	44392966	66097	None	0	Human	Binding	pKi	=	7.9	7.9	10	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3C(CCC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL183903	66097	None	0	Human	Binding	pKi	=	7.9	7.9	10	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3C(CCC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	11808040	168393	None	0	Human	Binding	pKi	=	7.9	7.9	2	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	4	0	2	3.8	CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL434684	168393	None	0	Human	Binding	pKi	=	7.9	7.9	2	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	4	0	2	3.8	CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	75167447	178284	None	0	Human	Binding	pKi	=	7.9	7.9	-23	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4634230	178284	None	0	Human	Binding	pKi	=	7.9	7.9	-23	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650933	178284	None	0	Human	Binding	pKi	=	7.9	7.9	-23	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	44233190	103400	None	0	Human	Binding	pKi	=	7.9	7.9	-7	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084679	103400	None	0	Human	Binding	pKi	=	7.9	7.9	-7	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	324	1923	None	15	Rat	Binding	pKi	=	7.9	7.9	-1	9	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
	6436265	1923	None	15	Rat	Binding	pKi	=	7.9	7.9	-1	9	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
	CHEMBL277642	1923	None	15	Rat	Binding	pKi	=	7.9	7.9	-1	9	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
	154417	93258	None	60	Human	Binding	pKi	=	7.9	7.9	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL1331216	93258	None	60	Human	Binding	pKi	=	7.9	7.9	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL2449003	93258	None	60	Human	Binding	pKi	=	7.9	7.9	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	DB00424	93258	None	60	Human	Binding	pKi	=	7.9	7.9	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	10418181	9584	None	1	Rat	Binding	pKi	=	7.9	7.9	-5	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112500	9584	None	1	Rat	Binding	pKi	=	7.9	7.9	-5	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201995	9584	None	1	Rat	Binding	pKi	=	7.9	7.9	-5	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	205895	11866	None	2	Rat	Binding	pKi	=	6.9	6.9	1	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	CHEMBL118240	11866	None	2	Rat	Binding	pKi	=	6.9	6.9	1	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	154059	3635	None	51	Rat	Binding	pKi	=	6.9	6.9	-3	8	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
	2457	3635	None	51	Rat	Binding	pKi	=	6.9	6.9	-3	8	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
	7483	3635	None	51	Rat	Binding	pKi	=	6.9	6.9	-3	8	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
	CHEMBL1734	3635	None	51	Rat	Binding	pKi	=	6.9	6.9	-3	8	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
	DB01591	3635	None	51	Rat	Binding	pKi	=	6.9	6.9	-3	8	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
	3652	4095	None	79	Human	Binding	pKi	=	6.9	6.9	-18	18	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
	57	4095	None	79	Human	Binding	pKi	=	6.9	6.9	-18	18	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
	60809	4095	None	79	Human	Binding	pKi	=	6.9	6.9	-18	18	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	6.9	6.9	-18	18	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
	DB15357	4095	None	79	Human	Binding	pKi	=	6.9	6.9	-18	18	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
	155515662	169962	None	0	Human	Binding	pKi	=	6.9	6.9	-1	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	336	4	0	3	3.9	O=C(OCc1ccccc1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	CHEMBL4441786	169962	None	0	Human	Binding	pKi	=	6.9	6.9	-1	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	336	4	0	3	3.9	O=C(OCc1ccccc1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	2200	3129	None	46	Rat	Binding	pKi	=	6.9	6.9	-31	13	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	328	3129	None	46	Rat	Binding	pKi	=	6.9	6.9	-31	13	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	4848	3129	None	46	Rat	Binding	pKi	=	6.9	6.9	-31	13	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	6.9	6.9	-31	13	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	DB00670	3129	None	46	Rat	Binding	pKi	=	6.9	6.9	-31	13	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	154059	3635	None	51	Human	Binding	pKi	=	6.9	6.9	-12	8	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
	2457	3635	None	51	Human	Binding	pKi	=	6.9	6.9	-12	8	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
	7483	3635	None	51	Human	Binding	pKi	=	6.9	6.9	-12	8	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
	CHEMBL1734	3635	None	51	Human	Binding	pKi	=	6.9	6.9	-12	8	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
	DB01591	3635	None	51	Human	Binding	pKi	=	6.9	6.9	-12	8	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
	44308910	203740	None	0	Human	Binding	pKi	=	5.9	5.9	-39	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	324	3	2	3	1.7	O=C(N1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL67814	203740	None	0	Human	Binding	pKi	=	5.9	5.9	-39	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	324	3	2	3	1.7	O=C(N1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	9794266	157149	None	0	Human	Binding	pKi	=	5.9	5.9	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	205	2	0	2	2.1	COc1cccc2c1CC(N(C)C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4075227	157149	None	0	Human	Binding	pKi	=	5.9	5.9	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	205	2	0	2	2.1	COc1cccc2c1CC(N(C)C)CC2	10.1021/acs.jmedchem.7b01113
	44318817	169112	None	0	Human	Binding	pKi	=	5.9	5.9	-7	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	CHEMBL440138	169112	None	0	Human	Binding	pKi	=	5.9	5.9	-7	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	16086065	79795	None	0	Human	Binding	pKi	=	5.9	5.9	-426	4	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	622	10	3	5	3.9	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	CHEMBL211976	79795	None	0	Human	Binding	pKi	=	5.9	5.9	-426	4	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	622	10	3	5	3.9	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	3072501	107267	None	6	Mouse	Binding	pKi	=	4.9	4.9	-	1	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL316973	107267	None	6	Mouse	Binding	pKi	=	4.9	4.9	-	1	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	5747382	109201	None	3	Mouse	Binding	pKi	=	4.9	4.9	-	1	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL321605	109201	None	3	Mouse	Binding	pKi	=	4.9	4.9	-	1	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	71716224	86954	None	0	Rat	Binding	pKi	=	4.9	4.9	-13	3	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323444	86954	None	0	Rat	Binding	pKi	=	4.9	4.9	-13	3	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	71451002	79708	None	0	Rat	Binding	pKi	=	4.9	4.9	1	2	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
	CHEMBL2115494	79708	None	0	Rat	Binding	pKi	=	4.9	4.9	1	2	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
	71451002	79708	None	0	Rat	Binding	pKi	=	4.9	4.9	1	2	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
	CHEMBL2115494	79708	None	0	Rat	Binding	pKi	=	4.9	4.9	1	2	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
	657347	5074	None	2	Human	Binding	pKi	=	5.9	5.9	-10	6	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL105457	5074	None	2	Human	Binding	pKi	=	5.9	5.9	-10	6	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL387632	5074	None	2	Human	Binding	pKi	=	5.9	5.9	-10	6	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	72190449	92270	None	0	Human	Binding	pKi	=	5.9	5.9	-4	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426676	92270	None	0	Human	Binding	pKi	=	5.9	5.9	-4	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	657347	5074	None	2	Human	Binding	pKi	=	5.9	5.9	-10	6	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	CHEMBL105457	5074	None	2	Human	Binding	pKi	=	5.9	5.9	-10	6	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	CHEMBL387632	5074	None	2	Human	Binding	pKi	=	5.9	5.9	-10	6	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	44274302	77065	None	0	Human	Binding	pKi	=	4.9	4.9	-1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL20732	77065	None	0	Human	Binding	pKi	=	4.9	4.9	-1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	2166	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
	305	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
	5910	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
	CHEMBL550	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
	DB01085	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
	44448419	12334	None	0	Human	Binding	pKi	=	4.9	4.9	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL1185266	12334	None	0	Human	Binding	pKi	=	4.9	4.9	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL403592	12334	None	0	Human	Binding	pKi	=	4.9	4.9	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	44295713	189746	None	0	Human	Binding	pKi	=	6.9	6.9	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	495	6	1	3	5.8	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)Nc4ccccc4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL51588	189746	None	0	Human	Binding	pKi	=	6.9	6.9	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	495	6	1	3	5.8	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)Nc4ccccc4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	71459604	83791	None	0	Human	Binding	pKi	=	5.9	5.9	-2	14	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205811	83791	None	0	Human	Binding	pKi	=	5.9	5.9	-2	14	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	463319	119394	None	1	Human	Binding	pKi	=	5.9	5.9	-102	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	579	5	0	5	6.5	Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL344607	119394	None	1	Human	Binding	pKi	=	5.9	5.9	-102	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	579	5	0	5	6.5	Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	1971	2864	None	38	Human	Binding	pKi	=	6.9	6.9	-9	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	2404	2864	None	38	Human	Binding	pKi	=	6.9	6.9	-9	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	4543	2864	None	38	Human	Binding	pKi	=	6.9	6.9	-9	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	CHEMBL445	2864	None	38	Human	Binding	pKi	=	6.9	6.9	-9	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	DB00540	2864	None	38	Human	Binding	pKi	=	6.9	6.9	-9	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	14967772	13411	None	7	Rat	Binding	pKi	=	6.9	6.9	-58	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1192807	13411	None	7	Rat	Binding	pKi	=	6.9	6.9	-58	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL544107	13411	None	7	Rat	Binding	pKi	=	6.9	6.9	-58	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
	688567	63032	None	4	Rat	Binding	pKi	=	6.9	6.9	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	CHEMBL1788199	63032	None	4	Rat	Binding	pKi	=	6.9	6.9	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	10251468	94067	None	0	Rat	Binding	pKi	=	5.9	5.9	-20	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.2	Cc1ccc(C(C)N2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
	CHEMBL249006	94067	None	0	Rat	Binding	pKi	=	5.9	5.9	-20	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.2	Cc1ccc(C(C)N2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
	2551	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
	298	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
	488	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
	CHEMBL965	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
	DB00411	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
	12963076	196623	None	4	Human	Binding	pKi	=	5.9	5.9	-2951	7	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL564226	196623	None	4	Human	Binding	pKi	=	5.9	5.9	-2951	7	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	109018479	181816	None	1	Human	Binding	pKi	=	5.9	5.9	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	CHEMBL4778178	181816	None	1	Human	Binding	pKi	=	5.9	5.9	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	2551	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	298	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	488	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	CHEMBL965	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	DB00411	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	2551	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
	298	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
	488	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
	CHEMBL965	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
	DB00411	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
	2551	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
	298	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
	488	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL965	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
	DB00411	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
	2551	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
	298	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
	488	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
	CHEMBL965	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
	DB00411	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
	145961125	161544	None	0	Human	Binding	pKi	=	5.9	5.9	-3	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4128667	161544	None	0	Human	Binding	pKi	=	5.9	5.9	-3	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	71463063	83799	None	0	Human	Binding	pKi	=	5.9	5.9	-2	8	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205825	83799	None	0	Human	Binding	pKi	=	5.9	5.9	-2	8	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	44318928	205761	None	0	Human	Binding	pKi	=	6.9	6.9	-28	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	CHEMBL82859	205761	None	0	Human	Binding	pKi	=	6.9	6.9	-28	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	250	3384	None	8	Human	Binding	pKi	=	5.9	5.9	-35481	13	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
	5311416	3384	None	8	Human	Binding	pKi	=	5.9	5.9	-35481	13	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
	CHEMBL69733	3384	None	8	Human	Binding	pKi	=	5.9	5.9	-35481	13	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
	24865895	96003	None	0	Human	Binding	pKi	=	5.9	5.9	1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL259662	96003	None	0	Human	Binding	pKi	=	5.9	5.9	1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL390842	96003	None	0	Human	Binding	pKi	=	5.9	5.9	1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	44274469	80606	None	1	Human	Binding	pKi	=	4.9	4.9	-1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21509	80606	None	1	Human	Binding	pKi	=	4.9	4.9	-1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	44406321	72776	None	0	Human	Binding	pKi	=	6.9	6.9	-15	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	415	3	1	3	4.3	CO[C@]1(C#CC(O)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL199981	72776	None	0	Human	Binding	pKi	=	6.9	6.9	-15	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	415	3	1	3	4.3	CO[C@]1(C#CC(O)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	6918276	15609	None	7	Human	Binding	pKi	=	5.9	5.9	-131	8	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	CHEMBL1221512	15609	None	7	Human	Binding	pKi	=	5.9	5.9	-131	8	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	60138186	120834	None	0	Human	Binding	pKi	=	5.9	5.9	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	60138193	120834	None	0	Human	Binding	pKi	=	5.9	5.9	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323288	120834	None	0	Human	Binding	pKi	=	5.9	5.9	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558240	120834	None	0	Human	Binding	pKi	=	5.9	5.9	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	44267712	162021	None	0	Human	Binding	pKi	=	6.9	6.9	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	515	7	1	5	4.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(S(N)(=O)=O)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL415975	162021	None	0	Human	Binding	pKi	=	6.9	6.9	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	515	7	1	5	4.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(S(N)(=O)=O)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	1548953	207677	None	27	Human	Binding	pKi	=	5.9	5.9	-6	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	CHEMBL954	207677	None	27	Human	Binding	pKi	=	5.9	5.9	-6	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	71452387	83801	None	0	Human	Binding	pKi	=	5.9	5.9	1	7	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2012.08.046
	CHEMBL2205829	83801	None	0	Human	Binding	pKi	=	5.9	5.9	1	7	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2012.08.046
	71452387	83801	None	0	Human	Binding	pKi	=	5.9	5.9	1	7	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmc.2013.07.045
	CHEMBL2205829	83801	None	0	Human	Binding	pKi	=	5.9	5.9	1	7	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmc.2013.07.045
	11006792	78920	None	0	Human	Binding	pKi	=	7.9	7.9	-5	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	648	12	2	4	5.9	O=C(CNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL2112961	78920	None	0	Human	Binding	pKi	=	7.9	7.9	-5	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	648	12	2	4	5.9	O=C(CNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	11501540	133601	None	0	Rat	Binding	pKi	=	7.9	7.9	-16	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
	CHEMBL371293	133601	None	0	Rat	Binding	pKi	=	7.9	7.9	-16	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
	44406598	73023	None	0	Human	Binding	pKi	=	7.9	7.9	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200957	73023	None	0	Human	Binding	pKi	=	7.9	7.9	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44383238	120625	None	0	Human	Binding	pKi	=	7.9	7.9	2	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	387	4	0	3	5.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC4CCCCC43)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL354636	120625	None	0	Human	Binding	pKi	=	7.9	7.9	2	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	387	4	0	3	5.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC4CCCCC43)[C@@H]12	10.1016/s0960-894x(99)00101-8
	59291452	112774	None	0	Rat	Binding	pKi	=	7.9	7.9	-3	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298590	112774	None	0	Rat	Binding	pKi	=	7.9	7.9	-3	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305615	112774	None	0	Rat	Binding	pKi	=	7.9	7.9	-3	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL5279174	194014	None	0	Human	Binding	pKi	=	7.9	7.9	-16	3	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	474	9	1	3	6.7	C#CCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	155541812	173048	None	0	Human	Binding	pKi	=	7.9	7.9	-7	5	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	5	0	3	4.1	O=C(OC1CN2CCC1CC2)N(CCc1ccc(F)cc1)c1ccccc1	10.1016/j.bmcl.2018.12.022
	CHEMBL4519301	173048	None	0	Human	Binding	pKi	=	7.9	7.9	-7	5	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	5	0	3	4.1	O=C(OC1CN2CCC1CC2)N(CCc1ccc(F)cc1)c1ccccc1	10.1016/j.bmcl.2018.12.022
	164623942	188577	None	0	Human	Binding	pKi	=	7.9	7.9	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4873621	188577	None	0	Human	Binding	pKi	=	7.9	7.9	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028796	188577	None	0	Human	Binding	pKi	=	7.9	7.9	3	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	156020548	178176	None	0	Human	Binding	pKi	=	7.9	7.9	-9	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4649224	178176	None	0	Human	Binding	pKi	=	7.9	7.9	-9	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	10759971	65251	None	0	Human	Binding	pKi	=	7.9	7.9	5	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL182761	65251	None	0	Human	Binding	pKi	=	7.9	7.9	5	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	44627748	14092	None	0	Human	Binding	pKi	=	7.9	7.9	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL1197705	14092	None	0	Human	Binding	pKi	=	7.9	7.9	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL583027	14092	None	0	Human	Binding	pKi	=	7.9	7.9	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	15050960	102325	None	0	Rat	Binding	pKi	=	7.9	7.9	-4	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	548	15	1	6	5.4	CCN(CC)CCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL303622	102325	None	0	Rat	Binding	pKi	=	7.9	7.9	-4	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	548	15	1	6	5.4	CCN(CC)CCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	2381	662	None	48	Human	Binding	pKi	=	7.9	7.9	-15	9	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
	374	662	None	48	Human	Binding	pKi	=	7.9	7.9	-15	9	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
	7128	662	None	48	Human	Binding	pKi	=	7.9	7.9	-15	9	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
	CHEMBL1101	662	None	48	Human	Binding	pKi	=	7.9	7.9	-15	9	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
	DB00810	662	None	48	Human	Binding	pKi	=	7.9	7.9	-15	9	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
	156021441	178152	None	0	Human	Binding	pKi	=	7.9	7.9	-2	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4648939	178152	None	0	Human	Binding	pKi	=	7.9	7.9	-2	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	44308912	102831	None	0	Human	Binding	pKi	=	6.9	6.9	-61	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	2	3	2.1	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL305531	102831	None	0	Human	Binding	pKi	=	6.9	6.9	-61	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	2	3	2.1	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)C1	10.1016/s0960-894x(03)00350-0
	155562285	175840	None	0	Human	Binding	pKi	=	6.9	6.9	-16	5	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	6	0	4	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1	10.1016/j.bmcl.2018.12.022
	CHEMBL4585326	175840	None	0	Human	Binding	pKi	=	6.9	6.9	-16	5	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	6	0	4	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1	10.1016/j.bmcl.2018.12.022
	44296044	194668	None	0	Human	Binding	pKi	=	5.9	5.9	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	555	6	1	3	6.6	O=C(NC1CCCCC1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL53190	194668	None	0	Human	Binding	pKi	=	5.9	5.9	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	555	6	1	3	6.6	O=C(NC1CCCCC1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	14964499	169387	None	3	Rat	Binding	pKi	=	5.9	5.9	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL442206	169387	None	3	Rat	Binding	pKi	=	5.9	5.9	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	15196354	119268	None	0	Human	Binding	pKi	=	5.9	5.9	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
	CHEMBL343697	119268	None	0	Human	Binding	pKi	=	5.9	5.9	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
	2551	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
	298	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
	488	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
	CHEMBL965	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
	DB00411	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
	137630994	161138	None	0	Human	Binding	pKi	=	5.9	5.9	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4103375	161138	None	0	Human	Binding	pKi	=	5.9	5.9	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4117267	161138	None	0	Human	Binding	pKi	=	5.9	5.9	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	10421982	206039	None	0	Human	Binding	pKi	=	5.9	5.9	1	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
	CHEMBL85190	206039	None	0	Human	Binding	pKi	=	5.9	5.9	1	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
	16086061	80216	None	0	Human	Binding	pKi	=	5.9	5.9	-1412	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	690	10	2	5	4.6	CCN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
	CHEMBL213709	80216	None	0	Human	Binding	pKi	=	5.9	5.9	-1412	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	690	10	2	5	4.6	CCN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
	10597259	119255	None	0	Human	Binding	pKi	=	5.9	5.9	-67	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](F)C2)CC1	10.1021/jm0003135
	CHEMBL343644	119255	None	0	Human	Binding	pKi	=	5.9	5.9	-67	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](F)C2)CC1	10.1021/jm0003135
	14964499	169387	None	3	Rat	Binding	pKi	=	4.9	4.9	-	1	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL442206	169387	None	3	Rat	Binding	pKi	=	4.9	4.9	-	1	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	14964506	113314	None	1	Rat	Binding	pKi	=	4.9	4.9	-6	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL331556	113314	None	1	Rat	Binding	pKi	=	4.9	4.9	-6	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	137629935	161018	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	118710670	120831	None	0	Human	Binding	pKi	=	6.9	6.9	-1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323284	120831	None	0	Human	Binding	pKi	=	6.9	6.9	-1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558233	120831	None	0	Human	Binding	pKi	=	6.9	6.9	-1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	2551	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	298	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	488	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	CHEMBL965	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	DB00411	793	None	23	Human	Binding	pKi	=	5.9	5.9	-6	11	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	164612852	188481	None	0	Human	Binding	pKi	=	5.9	5.9	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852544	188481	None	0	Human	Binding	pKi	=	5.9	5.9	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028161	188481	None	0	Human	Binding	pKi	=	5.9	5.9	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	164627387	188604	None	0	Human	Binding	pKi	=	5.9	5.9	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4874785	188604	None	0	Human	Binding	pKi	=	5.9	5.9	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028995	188604	None	0	Human	Binding	pKi	=	5.9	5.9	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	162353369	180793	None	0	Human	Binding	pKi	=	4.9	4.9	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756442	180793	None	0	Human	Binding	pKi	=	4.9	4.9	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	19021478	192695	None	0	Human	Binding	pKi	=	6.9	6.9	5	3	Binding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constantBinding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constant	ChEMBL	356	4	1	3	4.5	CNC(=O)Oc1cccc2c1CCC1C2CCN1CCC1CCCCC1	10.1016/j.ejmech.2022.114606
	CHEMBL5219452	192695	None	0	Human	Binding	pKi	=	6.9	6.9	5	3	Binding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constantBinding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constant	ChEMBL	356	4	1	3	4.5	CNC(=O)Oc1cccc2c1CCC1C2CCN1CCC1CCCCC1	10.1016/j.ejmech.2022.114606
	3497	1180	None	25	Human	Binding	pKi	=	5.9	5.9	-47	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
	5311123	1180	None	25	Human	Binding	pKi	=	5.9	5.9	-47	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
	CHEMBL1628706	1180	None	25	Human	Binding	pKi	=	5.9	5.9	-47	3	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
	457875	5227	None	1	Human	Binding	pKi	=	5.9	5.9	-22	3	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	482	4	0	2	6.0	Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Cc3ccc(Br)cc3)CC2)CC1	10.1021/jm0200815
	CHEMBL106247	5227	None	1	Human	Binding	pKi	=	5.9	5.9	-22	3	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	482	4	0	2	6.0	Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Cc3ccc(Br)cc3)CC2)CC1	10.1021/jm0200815
	44267754	15251	None	0	Human	Binding	pKi	=	6.9	6.9	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.1	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(Cl)cc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12115	15251	None	0	Human	Binding	pKi	=	6.9	6.9	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.1	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(Cl)cc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44267714	97373	None	0	Human	Binding	pKi	=	6.9	6.9	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	427	6	0	5	4.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccno4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL269645	97373	None	0	Human	Binding	pKi	=	6.9	6.9	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	427	6	0	5	4.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccno4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	4601	206745	None	35	Human	Binding	pKi	=	6.9	6.9	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL1201023	206745	None	35	Human	Binding	pKi	=	6.9	6.9	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL900	206745	None	35	Human	Binding	pKi	=	6.9	6.9	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	DB01173	206745	None	35	Human	Binding	pKi	=	6.9	6.9	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	73350398	89796	None	0	Human	Binding	pKi	=	5.9	5.9	-12	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	363	8	0	4	5.0	CCN(CC)CCOC(=O)c1ccccc1Sc1ccc(Cl)cc1	10.1016/j.bmc.2013.01.072
	CHEMBL2377262	89796	None	0	Human	Binding	pKi	=	5.9	5.9	-12	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	363	8	0	4	5.0	CCN(CC)CCOC(=O)c1ccccc1Sc1ccc(Cl)cc1	10.1016/j.bmc.2013.01.072
	15678859	102773	None	0	Rat	Binding	pKi	=	5.9	5.9	-1	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	436	8	2	6	2.4	NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL305197	102773	None	0	Rat	Binding	pKi	=	5.9	5.9	-1	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	436	8	2	6	2.4	NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	71463061	83793	None	0	Human	Binding	pKi	=	5.9	5.9	-1	9	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
	CHEMBL2205813	83793	None	0	Human	Binding	pKi	=	5.9	5.9	-1	9	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
	156015968	178243	None	0	Human	Binding	pKi	=	5.9	5.9	-2	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4648657	178243	None	0	Human	Binding	pKi	=	5.9	5.9	-2	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650620	178243	None	0	Human	Binding	pKi	=	5.9	5.9	-2	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	10874119	4905	None	0	Human	Binding	pKi	=	5.9	5.9	-18	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	454	4	1	5	5.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OCc5ccccc5)c34)OC21	10.1021/jm011116o
	CHEMBL104574	4905	None	0	Human	Binding	pKi	=	5.9	5.9	-18	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	454	4	1	5	5.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OCc5ccccc5)c34)OC21	10.1021/jm011116o
	10862395	5024	None	0	Human	Binding	pKi	=	5.9	5.9	-338	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	4	1	5	4.4	CCOC(=O)c1c(CC)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL105148	5024	None	0	Human	Binding	pKi	=	5.9	5.9	-338	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	4	1	5	4.4	CCOC(=O)c1c(CC)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	44312468	204585	None	0	Human	Binding	pKi	=	6.9	6.9	1	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	402	5	0	5	3.4	CCOC(=O)N1CCN(C(C)c2ccc(S(=O)(=O)c3ccccc3)cc2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL73145	204585	None	0	Human	Binding	pKi	=	6.9	6.9	1	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	402	5	0	5	3.4	CCOC(=O)N1CCN(C(C)c2ccc(S(=O)(=O)c3ccccc3)cc2)CC1	10.1016/s0960-894x(00)00438-8
	44443732	94236	None	0	Rat	Binding	pKi	=	5.9	5.9	-41	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL250030	94236	None	0	Rat	Binding	pKi	=	5.9	5.9	-41	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	15050940	102825	None	0	Rat	Binding	pKi	=	5.9	5.9	1	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	375	3	1	5	1.6	C#CCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL305501	102825	None	0	Rat	Binding	pKi	=	5.9	5.9	1	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	375	3	1	5	1.6	C#CCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	13773338	79587	None	0	Rat	Binding	pKi	=	4.9	4.9	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2114395	79587	None	0	Rat	Binding	pKi	=	4.9	4.9	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	13773338	79587	None	0	Rat	Binding	pKi	=	5.9	5.9	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2114395	79587	None	0	Rat	Binding	pKi	=	5.9	5.9	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	44382125	120414	None	0	Human	Binding	pKi	=	6.9	6.9	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	9	0	7	3.6	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL353689	120414	None	0	Human	Binding	pKi	=	6.9	6.9	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	9	0	7	3.6	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	164617650	188519	None	0	Human	Binding	pKi	=	5.9	5.9	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4860171	188519	None	0	Human	Binding	pKi	=	5.9	5.9	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028445	188519	None	0	Human	Binding	pKi	=	5.9	5.9	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	156014875	178239	None	0	Human	Binding	pKi	=	5.9	5.9	1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4640846	178239	None	0	Human	Binding	pKi	=	5.9	5.9	1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650577	178239	None	0	Human	Binding	pKi	=	5.9	5.9	1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	46227413	14138	None	0	Human	Binding	pKi	=	4.9	4.9	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL1198087	14138	None	0	Human	Binding	pKi	=	4.9	4.9	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL595265	14138	None	0	Human	Binding	pKi	=	4.9	4.9	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
	44267728	14745	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	4	7.3	CCOc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
	CHEMBL12064	14745	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	4	7.3	CCOc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
	2028	2977	None	80	Rat	Binding	pKi	=	7.9	7.9	-5	11	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
	359	2977	None	80	Rat	Binding	pKi	=	7.9	7.9	-5	11	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
	4634	2977	None	80	Rat	Binding	pKi	=	7.9	7.9	-5	11	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
	CHEMBL1231	2977	None	80	Rat	Binding	pKi	=	7.9	7.9	-5	11	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
	DB01062	2977	None	80	Rat	Binding	pKi	=	7.9	7.9	-5	11	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
	44382652	59024	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	7	0	8	3.3	CC(C)S(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL169313	59024	None	0	Human	Binding	pKi	=	7.9	7.9	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	7	0	8	3.3	CC(C)S(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	90645361	112814	None	0	Rat	Binding	pKi	=	7.9	7.9	-7	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298601	112814	None	0	Rat	Binding	pKi	=	7.9	7.9	-7	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307123	112814	None	0	Rat	Binding	pKi	=	7.9	7.9	-7	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	10373706	57407	None	0	Rat	Binding	pKi	=	7.9	7.9	-2	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	959	31	2	10	10.2	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
	CHEMBL165220	57407	None	0	Rat	Binding	pKi	=	7.9	7.9	-2	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	959	31	2	10	10.2	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
	154734599	2501	None	12	Human	Binding	pKi	=	7.8	7.8	1	12	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
	327	2501	None	12	Human	Binding	pKi	=	7.8	7.8	1	12	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
	4108	2501	None	12	Human	Binding	pKi	=	7.8	7.8	1	12	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	7.8	7.8	1	12	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
	44324848	206778	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	7	0	8	5.9	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL90199	206778	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	7	0	8	5.9	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	154734599	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	327	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	4108	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL27673	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	71741394	120833	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323287	120833	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558239	120833	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	154734599	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
	327	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
	4108	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
	CHEMBL27673	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
	154734599	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	327	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	4108	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL27673	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	164611187	188468	None	0	Human	Binding	pKi	=	7.8	7.8	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4851265	188468	None	0	Human	Binding	pKi	=	7.8	7.8	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028060	188468	None	0	Human	Binding	pKi	=	7.8	7.8	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	6338102	100463	None	1	Rat	Binding	pKi	=	6.9	6.9	20	3	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL290723	100463	None	1	Rat	Binding	pKi	=	6.9	6.9	20	3	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL59587	100463	None	1	Rat	Binding	pKi	=	6.9	6.9	20	3	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	11552283	71688	None	0	Rat	Binding	pKi	=	6.9	6.9	-15	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	3	0	4	3.8	O=C(O[C@H]1CN2CCC1CC2)C1CCc2ccccc2N1c1ccccc1	10.1021/jm050099q
	CHEMBL196481	71688	None	0	Rat	Binding	pKi	=	6.9	6.9	-15	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	3	0	4	3.8	O=C(O[C@H]1CN2CCC1CC2)C1CCc2ccccc2N1c1ccccc1	10.1021/jm050099q
	137630667	161090	None	0	Human	Binding	pKi	=	6.9	6.9	-6	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4100938	161090	None	0	Human	Binding	pKi	=	6.9	6.9	-6	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116890	161090	None	0	Human	Binding	pKi	=	6.9	6.9	-6	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	11796409	38389	None	0	Human	Binding	pKi	=	5.9	5.9	-89	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
	CHEMBL146351	38389	None	0	Human	Binding	pKi	=	5.9	5.9	-89	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
	155515982	170008	None	0	Human	Binding	pKi	=	4.9	4.9	-56234	17	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	CHEMBL4442460	170008	None	0	Human	Binding	pKi	=	4.9	4.9	-56234	17	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	170332	160974	None	1	Human	Binding	pKi	=	4.9	4.9	3	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Binding	pKi	=	4.9	4.9	3	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Binding	pKi	=	4.9	4.9	3	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	137629919	161007	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4095626	161007	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116258	161007	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	10386	161166	None	16	Human	Binding	pKi	=	4.9	4.9	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4092348	161166	None	16	Human	Binding	pKi	=	4.9	4.9	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117554	161166	None	16	Human	Binding	pKi	=	4.9	4.9	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	10810094	119558	None	0	Human	Binding	pKi	=	4.9	4.9	-52	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	6	2	3	3.8	O=C(NC1CCN(CC2CCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL345985	119558	None	0	Human	Binding	pKi	=	4.9	4.9	-52	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	6	2	3	3.8	O=C(NC1CCN(CC2CCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	9976808	103440	None	0	Rat	Binding	pKi	=	6.9	6.9	-11	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
	CHEMBL3084892	103440	None	0	Rat	Binding	pKi	=	6.9	6.9	-11	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
	156015895	178279	None	0	Human	Binding	pKi	=	6.9	6.9	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4643290	178279	None	0	Human	Binding	pKi	=	6.9	6.9	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650874	178279	None	0	Human	Binding	pKi	=	6.9	6.9	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	44627742	198375	None	0	Human	Binding	pKi	=	6.9	6.9	-10	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	323	4	0	2	5.8	CN1CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL576707	198375	None	0	Human	Binding	pKi	=	6.9	6.9	-10	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	323	4	0	2	5.8	CN1CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	44593623	187878	None	0	Human	Binding	pKi	=	6.9	6.9	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496503	187878	None	0	Human	Binding	pKi	=	6.9	6.9	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539373	187878	None	0	Human	Binding	pKi	=	6.9	6.9	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	44450622	95831	None	0	Human	Binding	pKi	=	5.9	5.9	4	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	CHEMBL258907	95831	None	0	Human	Binding	pKi	=	5.9	5.9	4	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	167962	4067	None	4	Human	Binding	pKi	=	5.9	5.9	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4067	None	4	Human	Binding	pKi	=	5.9	5.9	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4067	None	4	Human	Binding	pKi	=	5.9	5.9	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	44274432	80125	None	0	Human	Binding	pKi	=	4.9	4.9	3	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21328	80125	None	0	Human	Binding	pKi	=	4.9	4.9	3	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	58438475	92271	None	0	Human	Binding	pKi	=	4.9	4.9	-1548	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426677	92271	None	0	Human	Binding	pKi	=	4.9	4.9	-1548	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	24894635	169805	None	0	Human	Binding	pKi	=	4.9	4.9	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
	CHEMBL443939	169805	None	0	Human	Binding	pKi	=	4.9	4.9	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
	CHEMBL527880	169805	None	0	Human	Binding	pKi	=	4.9	4.9	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
	44443721	94260	None	0	Rat	Binding	pKi	=	5.9	5.9	-14	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	390	6	2	3	3.3	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL250203	94260	None	0	Rat	Binding	pKi	=	5.9	5.9	-14	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	390	6	2	3	3.3	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	11012653	120818	None	0	Human	Binding	pKi	=	6.8	6.8	6	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	6	0	2	4.9	CC(C1=C(CCN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL355769	120818	None	0	Human	Binding	pKi	=	6.8	6.8	6	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	6	0	2	4.9	CC(C1=C(CCN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	164617938	188524	None	0	Human	Binding	pKi	=	6.8	6.8	3	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854179	188524	None	0	Human	Binding	pKi	=	6.8	6.8	3	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028470	188524	None	0	Human	Binding	pKi	=	6.8	6.8	3	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	10969696	132103	None	0	Human	Binding	pKi	=	5.8	5.8	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	334	5	0	3	3.9	CC(C1=C(CCN2CCOCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL369575	132103	None	0	Human	Binding	pKi	=	5.8	5.8	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	334	5	0	3	3.9	CC(C1=C(CCN2CCOCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	44593621	193295	None	0	Human	Binding	pKi	=	5.8	5.8	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL524061	193295	None	0	Human	Binding	pKi	=	5.8	5.8	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	10160219	4928	None	0	Human	Binding	pKi	=	5.8	5.8	-1445	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	436	5	1	5	5.5	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	CHEMBL104693	4928	None	0	Human	Binding	pKi	=	5.8	5.8	-1445	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	436	5	1	5	5.5	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	72190451	92274	None	0	Human	Binding	pKi	=	4.8	4.8	-524	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426680	92274	None	0	Human	Binding	pKi	=	4.8	4.8	-524	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	24894632	189417	None	2	Human	Binding	pKi	=	4.8	4.8	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc(C2CCCN2C)o1	10.1021/jm800145d
	CHEMBL513277	189417	None	2	Human	Binding	pKi	=	4.8	4.8	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc(C2CCCN2C)o1	10.1021/jm800145d
	10020614	204765	None	0	Human	Binding	pKi	=	6.8	6.8	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	347	10	0	4	3.8	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCCC1	10.1021/jm00041a006
	CHEMBL74736	204765	None	0	Human	Binding	pKi	=	6.8	6.8	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	347	10	0	4	3.8	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCCC1	10.1021/jm00041a006
	13773342	79680	None	0	Rat	Binding	pKi	=	5.8	5.8	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2115341	79680	None	0	Rat	Binding	pKi	=	5.8	5.8	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	302	2975	None	25	Human	Binding	pKi	=	6.8	6.8	-34	8	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	4630	2975	None	25	Human	Binding	pKi	=	6.8	6.8	-34	8	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	CHEMBL7634	2975	None	25	Human	Binding	pKi	=	6.8	6.8	-34	8	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	CHEMBL4520788	213973	None	10	Human	Binding	pKi	=	5.8	5.8	-69	25	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a CHRM2Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a CHRM2	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
	10870954	120308	None	0	Human	Binding	pKi	=	4.8	4.8	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL352779	120308	None	0	Human	Binding	pKi	=	4.8	4.8	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	44384327	59787	None	0	Human	Binding	pKi	=	6.8	6.8	10	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	349	4	1	4	3.2	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(O)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL172646	59787	None	0	Human	Binding	pKi	=	6.8	6.8	10	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	349	4	1	4	3.2	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(O)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	71457690	83796	None	0	Human	Binding	pKi	=	5.8	5.8	-1	5	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205817	83796	None	0	Human	Binding	pKi	=	5.8	5.8	-1	5	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
	9976807	103433	None	1	Rat	Binding	pKi	=	5.8	5.8	-36	3	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	CHEMBL3084884	103433	None	1	Rat	Binding	pKi	=	5.8	5.8	-36	3	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	71455894	83800	None	0	Human	Binding	pKi	=	5.8	5.8	-1	12	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	CHEMBL2205827	83800	None	0	Human	Binding	pKi	=	5.8	5.8	-1	12	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	71455894	83800	None	0	Human	Binding	pKi	=	5.8	5.8	-1	12	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
	CHEMBL2205827	83800	None	0	Human	Binding	pKi	=	5.8	5.8	-1	12	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
	10336462	103432	None	0	Rat	Binding	pKi	=	7.8	7.8	-13	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	325	4	0	2	4.6	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
	CHEMBL3084883	103432	None	0	Rat	Binding	pKi	=	7.8	7.8	-13	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	325	4	0	2	4.6	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
	44295789	189436	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	501	6	1	3	5.6	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC4CCCCC4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL51339	189436	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	501	6	1	3	5.6	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC4CCCCC4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	14964496	8962	None	0	Rat	Binding	pKi	=	7.8	7.8	1	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL109815	8962	None	0	Rat	Binding	pKi	=	7.8	7.8	1	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	11561621	201801	None	0	Rat	Binding	pKi	=	7.8	7.8	-15	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccsc1	10.1021/jm050099q
	CHEMBL606903	201801	None	0	Rat	Binding	pKi	=	7.8	7.8	-15	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccsc1	10.1021/jm050099q
	9894922	120292	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	8	0	8	4.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)Cc4ccccc4)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
	CHEMBL352660	120292	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	8	0	8	4.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)Cc4ccccc4)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
	154734599	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
	327	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
	4108	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
	CHEMBL27673	2501	None	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
	54757332	67922	None	0	Human	Binding	pKi	=	7.8	7.8	-7	2	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	414	9	1	3	4.4	NC(=O)C(CCCN1CC[C@H](Oc2ccccc2)C1)(c1ccccc1)c1ccccc1	10.1021/jm200884j
	CHEMBL1910845	67922	None	0	Human	Binding	pKi	=	7.8	7.8	-7	2	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	414	9	1	3	4.4	NC(=O)C(CCCN1CC[C@H](Oc2ccccc2)C1)(c1ccccc1)c1ccccc1	10.1021/jm200884j
	410345	89801	None	4	Human	Binding	pKi	=	7.8	7.8	-1	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	333	8	1	4	3.4	CCN(CC)CCOC(=O)C(c1ccccc1)C1(O)CCCCC1	10.1016/j.bmc.2013.01.072
	CHEMBL2377269	89801	None	4	Human	Binding	pKi	=	7.8	7.8	-1	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	333	8	1	4	3.4	CCN(CC)CCOC(=O)C(c1ccccc1)C1(O)CCCCC1	10.1016/j.bmc.2013.01.072
	11748799	165409	None	0	Human	Binding	pKi	=	7.8	7.8	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.3	CN(C)CCC1=C(C(C)(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL423831	165409	None	0	Human	Binding	pKi	=	7.8	7.8	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.3	CN(C)CCC1=C(C(C)(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	10226457	12973	None	0	Human	Binding	pKi	=	7.8	7.8	-3	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL1189471	12973	None	0	Human	Binding	pKi	=	7.8	7.8	-3	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL538793	12973	None	0	Human	Binding	pKi	=	7.8	7.8	-3	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	9909908	13517	None	0	Human	Binding	pKi	=	7.8	7.8	1	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
	CHEMBL1193635	13517	None	0	Human	Binding	pKi	=	7.8	7.8	1	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
	CHEMBL545077	13517	None	0	Human	Binding	pKi	=	7.8	7.8	1	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
	11071537	26494	None	0	Human	Binding	pKi	=	7.8	7.8	1	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	495	17	0	10	5.5	COc1nsnc1OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL136027	26494	None	0	Human	Binding	pKi	=	7.8	7.8	1	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	495	17	0	10	5.5	COc1nsnc1OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	174174	523	None	49	Human	Binding	pKi	=	7.8	7.8	-7	14	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	260	523	None	49	Human	Binding	pKi	=	7.8	7.8	-7	14	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	320	523	None	49	Human	Binding	pKi	=	7.8	7.8	-7	14	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	7.8	7.8	-7	14	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	DB00572	523	None	49	Human	Binding	pKi	=	7.8	7.8	-7	14	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	302	2975	None	25	Mouse	Binding	pKi	=	5.8	5.8	-3	8	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	4630	2975	None	25	Mouse	Binding	pKi	=	5.8	5.8	-3	8	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	CHEMBL7634	2975	None	25	Mouse	Binding	pKi	=	5.8	5.8	-3	8	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	44267695	10722	None	0	Human	Binding	pKi	=	5.8	5.8	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	502	7	1	4	5.6	O=C(O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11710	10722	None	0	Human	Binding	pKi	=	5.8	5.8	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	502	7	1	4	5.6	O=C(O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	14964507	114353	None	1	Rat	Binding	pKi	=	5.8	5.8	-5	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL333107	114353	None	1	Rat	Binding	pKi	=	5.8	5.8	-5	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	303	2976	None	17	Rat	Binding	pKi	=	5.8	5.8	1	6	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	4629	2976	None	17	Rat	Binding	pKi	=	5.8	5.8	1	6	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	8595	2976	None	17	Rat	Binding	pKi	=	5.8	5.8	1	6	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL44674	2976	None	17	Rat	Binding	pKi	=	5.8	5.8	1	6	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	14685523	37752	None	2	Human	Binding	pKi	=	5.8	5.8	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	177	1	0	2	2.1	c1coc(C2CN3CCC2CC3)c1	10.1021/jm00003a011
	CHEMBL14580	37752	None	2	Human	Binding	pKi	=	5.8	5.8	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	177	1	0	2	2.1	c1coc(C2CN3CCC2CC3)c1	10.1021/jm00003a011
	15196236	119198	None	0	Human	Binding	pKi	=	5.8	5.8	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
	CHEMBL343236	119198	None	0	Human	Binding	pKi	=	5.8	5.8	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
	44415886	79833	None	0	Human	Binding	pKi	=	5.8	5.8	-630	4	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	607	8	2	4	4.3	CC(C)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL212141	79833	None	0	Human	Binding	pKi	=	5.8	5.8	-630	4	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	607	8	2	4	4.3	CC(C)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	44309108	103092	None	0	Human	Binding	pKi	=	4.8	4.8	-52	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	372	4	3	3	3.6	O=C(Nc1ccc2c(c1)CNC2)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL307554	103092	None	0	Human	Binding	pKi	=	4.8	4.8	-52	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	372	4	3	3	3.6	O=C(Nc1ccc2c(c1)CNC2)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	10830843	203961	None	0	Human	Binding	pKi	=	4.8	4.8	-48	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	3	3	2.2	O=C(NC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL69383	203961	None	0	Human	Binding	pKi	=	4.8	4.8	-48	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	3	3	2.2	O=C(NC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	44308799	204027	None	0	Human	Binding	pKi	=	4.8	4.8	-19	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	1	3	3.5	CN(C)CCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL69765	204027	None	0	Human	Binding	pKi	=	4.8	4.8	-19	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	1	3	3.5	CN(C)CCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	44285557	100151	None	0	Human	Binding	pKi	=	4.8	4.8	-1	2	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	181	0	0	2	1.7	C[C@H]1CCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	CHEMBL287834	100151	None	0	Human	Binding	pKi	=	4.8	4.8	-1	2	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	181	0	0	2	1.7	C[C@H]1CCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	137636830	161222	None	0	Human	Binding	pKi	=	4.8	4.8	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4061384	161222	None	0	Human	Binding	pKi	=	4.8	4.8	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117956	161222	None	0	Human	Binding	pKi	=	4.8	4.8	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	73356869	92266	None	0	Human	Binding	pKi	=	6.8	6.8	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426672	92266	None	0	Human	Binding	pKi	=	6.8	6.8	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	118710660	120829	None	0	Human	Binding	pKi	=	6.8	6.8	2	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323279	120829	None	0	Human	Binding	pKi	=	6.8	6.8	2	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558230	120829	None	0	Human	Binding	pKi	=	6.8	6.8	2	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	11740181	103423	None	0	Rat	Binding	pKi	=	5.8	5.8	-281	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(F)(F)F)cc1)C2	10.1021/jm00020a006
	CHEMBL3084873	103423	None	0	Rat	Binding	pKi	=	5.8	5.8	-281	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(F)(F)F)cc1)C2	10.1021/jm00020a006
	44274468	80604	None	0	Human	Binding	pKi	=	4.8	4.8	1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21508	80604	None	0	Human	Binding	pKi	=	4.8	4.8	1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	13773336	79681	None	0	Rat	Binding	pKi	=	6.8	6.8	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2115342	79681	None	0	Rat	Binding	pKi	=	6.8	6.8	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	10025038	168825	None	0	Rat	Binding	pKi	=	6.8	6.8	-26	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.3	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL437781	168825	None	0	Rat	Binding	pKi	=	6.8	6.8	-26	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.3	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	164626977	188597	None	0	Human	Binding	pKi	=	6.8	6.8	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4874412	188597	None	0	Human	Binding	pKi	=	6.8	6.8	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028969	188597	None	0	Human	Binding	pKi	=	6.8	6.8	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	4189	206920	None	96	Human	Binding	pKi	=	5.8	5.8	-18	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206920	None	96	Human	Binding	pKi	=	5.8	5.8	-18	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206920	None	96	Human	Binding	pKi	=	5.8	5.8	-18	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	72190452	92276	None	0	Human	Binding	pKi	=	5.8	5.8	-1	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426682	92276	None	0	Human	Binding	pKi	=	5.8	5.8	-1	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	145961126	161551	None	0	Human	Binding	pKi	=	5.8	5.8	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4128764	161551	None	0	Human	Binding	pKi	=	5.8	5.8	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	11523051	96287	None	0	Human	Binding	pKi	=	4.8	4.8	2	5	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2093084	96287	None	0	Human	Binding	pKi	=	4.8	4.8	2	5	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL261194	96287	None	0	Human	Binding	pKi	=	4.8	4.8	2	5	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	45266386	194914	None	0	Human	Binding	pKi	=	4.8	4.8	1	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	CHEMBL541424	194914	None	0	Human	Binding	pKi	=	4.8	4.8	1	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	23352279	207578	None	0	Human	Binding	pKi	=	5.8	5.8	-3	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	233	2	0	3	3.0	CC(=O)c1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
	CHEMBL94921	207578	None	0	Human	Binding	pKi	=	5.8	5.8	-3	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	233	2	0	3	3.0	CC(=O)c1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
	15105211	172874	None	0	Human	Binding	pKi	=	5.8	5.8	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	11	0	3	3.8	CCN(CC)CCOCCN(C)CC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL451542	172874	None	0	Human	Binding	pKi	=	5.8	5.8	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	11	0	3	3.8	CCN(CC)CCOCCN(C)CC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	16125398	85115	None	0	Human	Binding	pKi	=	6.8	6.8	-20	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL224783	85115	None	0	Human	Binding	pKi	=	6.8	6.8	-20	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	9969695	160886	None	0	Human	Binding	pKi	=	6.8	6.8	-15	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	361	4	0	3	3.7	COC(C#C[C@@]1(OC)CN2CCC1CC2)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.024
	CHEMBL411514	160886	None	0	Human	Binding	pKi	=	6.8	6.8	-15	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	361	4	0	3	3.7	COC(C#C[C@@]1(OC)CN2CCC1CC2)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.024
	187	255	None	39	Human	Binding	pKi	=	6.8	6.8	6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	294	255	None	39	Human	Binding	pKi	=	6.8	6.8	6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	65	255	None	39	Human	Binding	pKi	=	6.8	6.8	6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	8593	255	None	39	Human	Binding	pKi	=	6.8	6.8	6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	CHEMBL667	255	None	39	Human	Binding	pKi	=	6.8	6.8	6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	DB03128	255	None	39	Human	Binding	pKi	=	6.8	6.8	6	9	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	145961495	161444	None	0	Human	Binding	pKi	=	6.8	6.8	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4127373	161444	None	0	Human	Binding	pKi	=	6.8	6.8	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	11536903	2395	None	68	Human	Binding	pKi	=	6.8	6.8	-6	2	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	3262	2395	None	68	Human	Binding	pKi	=	6.8	6.8	-6	2	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	CHEMBL3770346	2395	None	68	Human	Binding	pKi	=	6.8	6.8	-6	2	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	16094810	137884	None	0	Human	Binding	pKi	=	6.8	6.8	-1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsnc1OCCCOCCCOCCCOc1nsnc1-c1cccnc1	10.1021/jm0606995
	CHEMBL376295	137884	None	0	Human	Binding	pKi	=	6.8	6.8	-1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsnc1OCCCOCCCOCCCOc1nsnc1-c1cccnc1	10.1021/jm0606995
	71456285	79593	None	0	Rat	Binding	pKi	=	4.8	4.8	1	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@@H]1CCCCN1	10.1021/jm00087a008
	CHEMBL2114426	79593	None	0	Rat	Binding	pKi	=	4.8	4.8	1	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@@H]1CCCCN1	10.1021/jm00087a008
	24865895	96003	None	0	Human	Binding	pKi	=	5.8	5.8	1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL259662	96003	None	0	Human	Binding	pKi	=	5.8	5.8	1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL390842	96003	None	0	Human	Binding	pKi	=	5.8	5.8	1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	24865895	96003	None	0	Human	Binding	pKi	=	5.8	5.8	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL259662	96003	None	0	Human	Binding	pKi	=	5.8	5.8	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL390842	96003	None	0	Human	Binding	pKi	=	5.8	5.8	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	44274433	99508	None	0	Human	Binding	pKi	=	4.8	4.8	1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL283320	99508	None	0	Human	Binding	pKi	=	4.8	4.8	1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	24894516	172706	None	0	Human	Binding	pKi	=	4.8	4.8	2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@@H]2CCCN2C)o1	10.1021/jm800145d
	CHEMBL450463	172706	None	0	Human	Binding	pKi	=	4.8	4.8	2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@@H]2CCCN2C)o1	10.1021/jm800145d
	15196233	121113	None	0	Human	Binding	pKi	=	4.8	4.8	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	233	2	1	3	1.6	COc1ccccc1C1(O)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL357404	121113	None	0	Human	Binding	pKi	=	4.8	4.8	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	233	2	1	3	1.6	COc1ccccc1C1(O)CN2CCC1CC2	10.1021/jm00003a011
	44378753	120280	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL352607	120280	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	2028	2977	None	80	Human	Binding	pKi	=	7.8	7.8	-8	11	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	359	2977	None	80	Human	Binding	pKi	=	7.8	7.8	-8	11	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	4634	2977	None	80	Human	Binding	pKi	=	7.8	7.8	-8	11	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	CHEMBL1231	2977	None	80	Human	Binding	pKi	=	7.8	7.8	-8	11	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	DB01062	2977	None	80	Human	Binding	pKi	=	7.8	7.8	-8	11	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	3042	1413	None	35	Human	Binding	pKi	=	7.8	7.8	-28	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	355	1413	None	35	Human	Binding	pKi	=	7.8	7.8	-28	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	868	1413	None	35	Human	Binding	pKi	=	7.8	7.8	-28	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	CHEMBL1123	1413	None	35	Human	Binding	pKi	=	7.8	7.8	-28	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	DB00804	1413	None	35	Human	Binding	pKi	=	7.8	7.8	-28	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	44392933	166301	None	0	Human	Binding	pKi	=	7.8	7.8	4	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	333	3	1	3	4.3	C[C@H]1CCC[C@H](CC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)N1	10.1016/j.bmcl.2004.05.047
	CHEMBL427145	166301	None	0	Human	Binding	pKi	=	7.8	7.8	4	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	333	3	1	3	4.3	C[C@H]1CCC[C@H](CC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)N1	10.1016/j.bmcl.2004.05.047
	118710660	120829	None	0	Human	Binding	pKi	=	7.8	7.8	2	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323279	120829	None	0	Human	Binding	pKi	=	7.8	7.8	2	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558230	120829	None	0	Human	Binding	pKi	=	7.8	7.8	2	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	118710662	120828	None	0	Human	Binding	pKi	=	7.8	7.8	1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323280	120828	None	0	Human	Binding	pKi	=	7.8	7.8	1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558229	120828	None	0	Human	Binding	pKi	=	7.8	7.8	1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	56965018	77179	None	0	Human	Binding	pKi	=	7.8	7.8	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042552	77179	None	0	Human	Binding	pKi	=	7.8	7.8	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2078967	77179	None	0	Human	Binding	pKi	=	7.8	7.8	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	164621443	188552	None	0	Human	Binding	pKi	=	7.8	7.8	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4867483	188552	None	0	Human	Binding	pKi	=	7.8	7.8	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028653	188552	None	0	Human	Binding	pKi	=	7.8	7.8	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015141	178265	None	0	Human	Binding	pKi	=	7.8	7.8	-1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4642045	178265	None	0	Human	Binding	pKi	=	7.8	7.8	-1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650774	178265	None	0	Human	Binding	pKi	=	7.8	7.8	-1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	174174	523	None	49	Human	Binding	pKi	=	7.8	7.8	-7	14	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	260	523	None	49	Human	Binding	pKi	=	7.8	7.8	-7	14	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	320	523	None	49	Human	Binding	pKi	=	7.8	7.8	-7	14	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	7.8	7.8	-7	14	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	DB00572	523	None	49	Human	Binding	pKi	=	7.8	7.8	-7	14	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	302	2975	None	25	Rat	Binding	pKi	=	6.8	6.8	-4	8	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	4630	2975	None	25	Rat	Binding	pKi	=	6.8	6.8	-4	8	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL7634	2975	None	25	Rat	Binding	pKi	=	6.8	6.8	-4	8	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	15196236	119198	None	0	Human	Binding	pKi	=	6.8	6.8	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
	CHEMBL343236	119198	None	0	Human	Binding	pKi	=	6.8	6.8	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
	199230	163133	None	21	Rat	Binding	pKi	=	5.8	5.8	37	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	CHEMBL41779	163133	None	21	Rat	Binding	pKi	=	5.8	5.8	37	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	6098192	201799	None	14	Rat	Binding	pKi	=	5.8	5.8	-3	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL606901	201799	None	14	Rat	Binding	pKi	=	5.8	5.8	-3	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL306462	102963	None	0	Human	Binding	pKi	=	5.8	5.8	-1	5	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	211	2	1	4	1.1	CCO/C(O)=C1\CN2CCCC(C2)C1=O	10.1021/jm020572p
	44318930	106170	None	0	Human	Binding	pKi	=	5.8	5.8	-2	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
	CHEMBL313738	106170	None	0	Human	Binding	pKi	=	5.8	5.8	-2	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
	53391301	92272	None	0	Human	Binding	pKi	=	5.8	5.8	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426678	92272	None	0	Human	Binding	pKi	=	5.8	5.8	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	462902	119851	None	1	Human	Binding	pKi	=	6.8	6.8	-8	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	460	4	0	6	3.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C#N)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL348667	119851	None	1	Human	Binding	pKi	=	6.8	6.8	-8	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	460	4	0	6	3.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C#N)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	10660	14414	None	58	Human	Binding	pKi	=	6.8	6.8	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	441281	14414	None	58	Human	Binding	pKi	=	6.8	6.8	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	CHEMBL1200406	14414	None	58	Human	Binding	pKi	=	6.8	6.8	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	DB00985	14414	None	58	Human	Binding	pKi	=	6.8	6.8	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	24894109	189026	None	0	Human	Binding	pKi	=	5.8	5.8	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL509202	189026	None	0	Human	Binding	pKi	=	5.8	5.8	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL551563	189026	None	0	Human	Binding	pKi	=	5.8	5.8	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	162353376	180425	None	0	Human	Binding	pKi	=	4.8	4.8	3	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4752380	180425	None	0	Human	Binding	pKi	=	4.8	4.8	3	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	14925759	158036	None	6	Human	Binding	pKi	=	4.8	4.8	-5754	13	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	349	5	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4085780	158036	None	6	Human	Binding	pKi	=	4.8	4.8	-5754	13	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	349	5	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	46227415	14127	None	0	Human	Binding	pKi	=	4.8	4.8	-	1	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL1198050	14127	None	0	Human	Binding	pKi	=	4.8	4.8	-	1	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL593871	14127	None	0	Human	Binding	pKi	=	4.8	4.8	-	1	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	16125683	84648	None	0	Human	Binding	pKi	=	6.8	6.8	-36	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	431	5	1	2	5.5	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(C4CCCCC4)NC3=O)CC2)c1	10.1021/jm061159a
	CHEMBL222403	84648	None	0	Human	Binding	pKi	=	6.8	6.8	-36	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	431	5	1	2	5.5	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(C4CCCCC4)NC3=O)CC2)c1	10.1021/jm061159a
	939078	63067	None	2	Rat	Binding	pKi	=	5.8	5.8	-12	2	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	CHEMBL1788286	63067	None	2	Rat	Binding	pKi	=	5.8	5.8	-12	2	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	2562	204597	None	56	Human	Binding	pKi	=	6.8	6.8	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL1256696	204597	None	56	Human	Binding	pKi	=	6.8	6.8	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL73234	204597	None	56	Human	Binding	pKi	=	6.8	6.8	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
	462573	29527	None	1	Human	Binding	pKi	=	5.8	5.8	-316	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1cncc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL138502	29527	None	1	Human	Binding	pKi	=	5.8	5.8	-316	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1cncc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	16125506	84777	None	0	Human	Binding	pKi	=	5.8	5.8	-1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	5.1	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCCc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL223187	84777	None	0	Human	Binding	pKi	=	5.8	5.8	-1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	5.1	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCCc2ccccc2)CC1	10.1021/jm061159a
	463210	164913	None	1	Human	Binding	pKi	=	6.8	6.8	-15	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	561	4	0	5	4.5	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(I)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL422326	164913	None	1	Human	Binding	pKi	=	6.8	6.8	-15	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	561	4	0	5	4.5	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(I)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	135398737	957	None	93	Human	Binding	pKi	=	6.8	6.8	-22	91	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	957	None	93	Human	Binding	pKi	=	6.8	6.8	-22	91	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	957	None	93	Human	Binding	pKi	=	6.8	6.8	-22	91	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	957	None	93	Human	Binding	pKi	=	6.8	6.8	-22	91	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	957	None	93	Human	Binding	pKi	=	6.8	6.8	-22	91	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	9968046	198161	None	0	Human	Binding	pKi	=	6.8	6.8	3	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL57485	198161	None	0	Human	Binding	pKi	=	6.8	6.8	3	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	44450637	155194	None	0	Human	Binding	pKi	=	5.8	5.8	12	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL402473	155194	None	0	Human	Binding	pKi	=	5.8	5.8	12	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
	162353379	180960	None	0	Human	Binding	pKi	=	5.8	5.8	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4758449	180960	None	0	Human	Binding	pKi	=	5.8	5.8	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	44386115	131436	None	0	Human	Binding	pKi	=	7.8	7.8	-8	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	650	16	3	4	6.2	O=C(CCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL369062	131436	None	0	Human	Binding	pKi	=	7.8	7.8	-8	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	650	16	3	4	6.2	O=C(CCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	44295977	192729	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL52203	192729	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44267762	15436	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	518	6	0	4	5.6	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12150	15436	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	518	6	0	4	5.6	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	9889312	78428	None	0	Human	Binding	pKi	=	7.8	7.8	2	5	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL2111540	78428	None	0	Human	Binding	pKi	=	7.8	7.8	2	5	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	44312066	164379	None	0	Human	Binding	pKi	=	7.8	7.8	3	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	494	7	0	4	6.4	COc1ccc([S+]([O-])c2ccc(C(C3CCCCC3)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL421304	164379	None	0	Human	Binding	pKi	=	7.8	7.8	3	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	494	7	0	4	6.4	COc1ccc([S+]([O-])c2ccc(C(C3CCCCC3)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	302	2975	None	25	Human	Binding	pKi	=	7.8	7.8	-34	8	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	4630	2975	None	25	Human	Binding	pKi	=	7.8	7.8	-34	8	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	CHEMBL7634	2975	None	25	Human	Binding	pKi	=	7.8	7.8	-34	8	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	71459971	79537	None	0	Human	Binding	pKi	=	7.8	7.8	1	3	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2114066	79537	None	0	Human	Binding	pKi	=	7.8	7.8	1	3	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	44627852	14037	None	0	Human	Binding	pKi	=	7.8	7.8	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197387	14037	None	0	Human	Binding	pKi	=	7.8	7.8	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569712	14037	None	0	Human	Binding	pKi	=	7.8	7.8	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	10314131	103422	None	0	Rat	Binding	pKi	=	7.8	7.8	-8	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	323	4	1	3	4.1	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(O)cc1)C2	10.1021/jm00020a006
	CHEMBL3084872	103422	None	0	Rat	Binding	pKi	=	7.8	7.8	-8	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	323	4	1	3	4.1	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(O)cc1)C2	10.1021/jm00020a006
	164627575	188606	None	0	Human	Binding	pKi	=	7.8	7.8	12	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4873979	188606	None	0	Human	Binding	pKi	=	7.8	7.8	12	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5029004	188606	None	0	Human	Binding	pKi	=	7.8	7.8	12	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44593625	188128	None	0	Human	Binding	pKi	=	7.8	7.8	-5	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL498358	188128	None	0	Human	Binding	pKi	=	7.8	7.8	-5	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539120	188128	None	0	Human	Binding	pKi	=	7.8	7.8	-5	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	44383415	120764	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	8	0	8	3.1	CCOCC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL355299	120764	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	8	0	8	3.1	CCOCC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	11819545	37403	None	0	Human	Binding	pKi	=	5.8	5.8	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccoc2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL145488	37403	None	0	Human	Binding	pKi	=	5.8	5.8	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccoc2)C2CCN1CC2	10.1021/jm00003a011
	11819883	120989	None	2	Human	Binding	pKi	=	5.8	5.8	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2ccsc2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL356321	120989	None	2	Human	Binding	pKi	=	5.8	5.8	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2ccsc2)C2CCN1CC2	10.1021/jm00003a011
	46878242	201809	None	0	Rat	Binding	pKi	=	5.8	5.8	-154	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@H](O)c2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL606962	201809	None	0	Rat	Binding	pKi	=	5.8	5.8	-154	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@H](O)c2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	146025727	171683	None	0	Human	Binding	pKi	=	5.8	5.8	-63	27	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	171683	None	0	Human	Binding	pKi	=	5.8	5.8	-63	27	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	44328561	207365	None	0	Human	Binding	pKi	=	5.8	5.8	-4	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	243	3	0	3	2.5	COc1ccccc1C(=O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
	CHEMBL93709	207365	None	0	Human	Binding	pKi	=	5.8	5.8	-4	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	243	3	0	3	2.5	COc1ccccc1C(=O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
	10105296	205920	None	0	Human	Binding	pKi	=	5.8	5.8	-2	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
	CHEMBL84113	205920	None	0	Human	Binding	pKi	=	5.8	5.8	-2	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
	155552185	174059	None	0	Human	Binding	pKi	=	4.8	4.8	-30902	16	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	CHEMBL4544086	174059	None	0	Human	Binding	pKi	=	4.8	4.8	-30902	16	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	45786849	157803	None	34	Human	Binding	pKi	=	4.8	4.8	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4083241	157803	None	34	Human	Binding	pKi	=	4.8	4.8	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	10718110	39913	None	0	Human	Binding	pKi	=	4.8	4.8	-1905	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	2	4	3.8	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
	CHEMBL147778	39913	None	0	Human	Binding	pKi	=	4.8	4.8	-1905	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	2	4	3.8	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
	10671167	121497	None	0	Human	Binding	pKi	=	4.8	4.8	-602	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	448	6	2	3	4.9	O=C(NC1CCN(CC2CCCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL358289	121497	None	0	Human	Binding	pKi	=	4.8	4.8	-602	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	448	6	2	3	4.9	O=C(NC1CCN(CC2CCCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	190868	13140	None	3	Rat	Binding	pKi	=	5.8	5.8	-1	2	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
	CHEMBL1190617	13140	None	3	Rat	Binding	pKi	=	5.8	5.8	-1	2	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
	CHEMBL541284	13140	None	3	Rat	Binding	pKi	=	5.8	5.8	-1	2	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
	2200	3129	None	46	Human	Binding	pKi	=	6.8	6.8	-35	13	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
	328	3129	None	46	Human	Binding	pKi	=	6.8	6.8	-35	13	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
	4848	3129	None	46	Human	Binding	pKi	=	6.8	6.8	-35	13	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.8	6.8	-35	13	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
	DB00670	3129	None	46	Human	Binding	pKi	=	6.8	6.8	-35	13	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
	73346332	92533	None	0	Human	Binding	pKi	=	5.8	5.8	1	4	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	297	3	0	2	2.6	CN(Cc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432041	92533	None	0	Human	Binding	pKi	=	5.8	5.8	1	4	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	297	3	0	2	2.6	CN(Cc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	44299616	195706	None	0	Human	Binding	pKi	=	5.8	5.8	-1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL55698	195706	None	0	Human	Binding	pKi	=	5.8	5.8	-1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	92218234	120825	None	1	Human	Binding	pKi	=	5.8	5.8	12	4	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
	CHEMBL3309718	120825	None	1	Human	Binding	pKi	=	5.8	5.8	12	4	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
	CHEMBL3558072	120825	None	1	Human	Binding	pKi	=	5.8	5.8	12	4	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
	46227411	14119	None	0	Human	Binding	pKi	=	4.8	4.8	2	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL1198027	14119	None	0	Human	Binding	pKi	=	4.8	4.8	2	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL593443	14119	None	0	Human	Binding	pKi	=	4.8	4.8	2	3	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	15678857	204030	None	0	Rat	Binding	pKi	=	5.8	5.8	1	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	408	6	2	6	1.7	NCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL69796	204030	None	0	Rat	Binding	pKi	=	5.8	5.8	1	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	408	6	2	6	1.7	NCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	156010212	178235	None	0	Human	Binding	pKi	=	6.8	6.8	-4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4634066	178235	None	0	Human	Binding	pKi	=	6.8	6.8	-4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650562	178235	None	0	Human	Binding	pKi	=	6.8	6.8	-4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	302	2975	None	25	Human	Binding	pKi	=	5.8	5.8	-34	8	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	4630	2975	None	25	Human	Binding	pKi	=	5.8	5.8	-34	8	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	CHEMBL7634	2975	None	25	Human	Binding	pKi	=	5.8	5.8	-34	8	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	137635734	156110	None	0	Human	Binding	pKi	=	5.8	5.8	-61	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	377	7	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4063176	156110	None	0	Human	Binding	pKi	=	5.8	5.8	-61	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	377	7	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	44296007	101962	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	529	5	1	3	6.1	CC(C)(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL301354	101962	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	529	5	1	3	6.1	CC(C)(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44267703	14956	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	501	7	1	4	5.0	NC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12085	14956	None	0	Human	Binding	pKi	=	7.8	7.8	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	501	7	1	4	5.0	NC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44344029	10118	None	0	Rat	Binding	pKi	=	7.8	7.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	632	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL115642	10118	None	0	Rat	Binding	pKi	=	7.8	7.8	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	632	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	15050957	203592	None	0	Rat	Binding	pKi	=	7.8	7.8	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	566	9	1	7	3.8	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL66914	203592	None	0	Rat	Binding	pKi	=	7.8	7.8	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	566	9	1	7	3.8	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	118710660	120829	None	0	Human	Binding	pKi	=	7.7	7.7	2	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323279	120829	None	0	Human	Binding	pKi	=	7.7	7.7	2	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558230	120829	None	0	Human	Binding	pKi	=	7.7	7.7	2	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	174174	523	None	49	Human	Binding	pKi	=	7.7	7.7	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	523	None	49	Human	Binding	pKi	=	7.7	7.7	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	523	None	49	Human	Binding	pKi	=	7.7	7.7	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	7.7	7.7	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	523	None	49	Human	Binding	pKi	=	7.7	7.7	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	118710660	120829	None	0	Human	Binding	pKi	=	7.7	7.7	2	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323279	120829	None	0	Human	Binding	pKi	=	7.7	7.7	2	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558230	120829	None	0	Human	Binding	pKi	=	7.7	7.7	2	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	14939895	82117	None	0	Rat	Binding	pKi	=	7.7	7.7	-4	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201997	82117	None	0	Rat	Binding	pKi	=	7.7	7.7	-4	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216629	82117	None	0	Rat	Binding	pKi	=	7.7	7.7	-4	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10404824	103429	None	0	Rat	Binding	pKi	=	7.7	7.7	-4	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	337	5	0	3	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	CHEMBL3084880	103429	None	0	Rat	Binding	pKi	=	7.7	7.7	-4	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	337	5	0	3	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	44392906	12258	None	0	Human	Binding	pKi	=	6.8	6.8	4	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL1184677	12258	None	0	Human	Binding	pKi	=	6.8	6.8	4	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL363895	12258	None	0	Human	Binding	pKi	=	6.8	6.8	4	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
	55005	104773	None	8	Rat	Binding	pKi	=	6.8	6.8	-1	3	Tested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heartTested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL310852	104773	None	8	Rat	Binding	pKi	=	6.8	6.8	-1	3	Tested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heartTested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	11610557	72029	None	0	Rat	Binding	pKi	=	5.8	5.8	-85	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
	CHEMBL197588	72029	None	0	Rat	Binding	pKi	=	5.8	5.8	-85	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
	10619926	39800	None	0	Human	Binding	pKi	=	5.8	5.8	-35	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	382	6	2	4	3.4	O=C(NC1CCN(Cc2ccoc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL147672	39800	None	0	Human	Binding	pKi	=	5.8	5.8	-35	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	382	6	2	4	3.4	O=C(NC1CCN(Cc2ccoc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	176	398	None	66	Human	Binding	pKi	=	5.7	5.7	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	398	None	66	Human	Binding	pKi	=	5.7	5.7	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	398	None	66	Human	Binding	pKi	=	5.7	5.7	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	398	None	66	Human	Binding	pKi	=	5.7	5.7	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	398	None	66	Human	Binding	pKi	=	5.7	5.7	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	10033774	56544	None	0	Rat	Binding	pKi	=	6.7	6.7	-4	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	927	31	0	8	12.0	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
	CHEMBL163901	56544	None	0	Rat	Binding	pKi	=	6.7	6.7	-4	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	927	31	0	8	12.0	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
	16125257	144674	None	0	Human	Binding	pKi	=	5.7	5.7	-7	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	350	3	1	1	3.2	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061160+
	CHEMBL390839	144674	None	0	Human	Binding	pKi	=	5.7	5.7	-7	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	350	3	1	1	3.2	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061160+
	57326142	77178	None	0	Human	Binding	pKi	=	4.7	4.7	4	2	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL2042401	77178	None	0	Human	Binding	pKi	=	4.7	4.7	4	2	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL2078965	77178	None	0	Human	Binding	pKi	=	4.7	4.7	4	2	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	46227457	14132	None	0	Human	Binding	pKi	=	4.7	4.7	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL1198075	14132	None	0	Human	Binding	pKi	=	4.7	4.7	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL594801	14132	None	0	Human	Binding	pKi	=	4.7	4.7	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	16125621	84361	None	0	Human	Binding	pKi	=	6.7	6.7	-22	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	426	5	2	3	4.2	Nc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	CHEMBL221829	84361	None	0	Human	Binding	pKi	=	6.7	6.7	-22	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	426	5	2	3	4.2	Nc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	2200	3129	None	46	Rat	Binding	pKi	=	4.7	4.7	-31	13	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	328	3129	None	46	Rat	Binding	pKi	=	4.7	4.7	-31	13	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	4848	3129	None	46	Rat	Binding	pKi	=	4.7	4.7	-31	13	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	4.7	4.7	-31	13	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	DB00670	3129	None	46	Rat	Binding	pKi	=	4.7	4.7	-31	13	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	44383064	120305	None	0	Human	Binding	pKi	=	6.7	6.7	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	381	4	0	3	4.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCc4ccccc4C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL352756	120305	None	0	Human	Binding	pKi	=	6.7	6.7	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	381	4	0	3	4.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCc4ccccc4C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	10807270	100455	None	0	Rat	Binding	pKi	=	5.7	5.7	5	2	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	342	3	1	3	3.8	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCCC1	10.1021/jm970333f
	CHEMBL290675	100455	None	0	Rat	Binding	pKi	=	5.7	5.7	5	2	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	342	3	1	3	3.8	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCCC1	10.1021/jm970333f
	162667844	182531	None	0	Human	Binding	pKi	=	4.7	4.7	-1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4787283	182531	None	0	Human	Binding	pKi	=	4.7	4.7	-1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	16124707	138144	None	0	Human	Binding	pKi	=	6.7	6.7	-67	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	5	1	4	4.9	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	CHEMBL376781	138144	None	0	Human	Binding	pKi	=	6.7	6.7	-67	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	5	1	4	4.9	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	44382841	59400	None	0	Human	Binding	pKi	=	6.7	6.7	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	351	4	0	4	3.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCSCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL170977	59400	None	0	Human	Binding	pKi	=	6.7	6.7	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	351	4	0	4	3.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCSCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	43815	186918	None	64	Human	Binding	pKi	=	6.7	6.7	-15	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	CHEMBL1708	186918	None	64	Human	Binding	pKi	=	6.7	6.7	-15	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	CHEMBL490	186918	None	64	Human	Binding	pKi	=	6.7	6.7	-15	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	5648	78409	None	9	Human	Binding	pKi	=	7.7	7.7	-2	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	CHEMBL2107687	78409	None	9	Human	Binding	pKi	=	7.7	7.7	-2	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	CHEMBL2111176	78409	None	9	Human	Binding	pKi	=	7.7	7.7	-2	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	16086063	80560	None	0	Human	Binding	pKi	=	7.7	7.7	-100	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	744	11	2	5	5.8	O=C(NCC1CCN(CC2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL214898	80560	None	0	Human	Binding	pKi	=	7.7	7.7	-100	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	744	11	2	5	5.8	O=C(NCC1CCN(CC2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	71741394	120833	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323287	120833	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558239	120833	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	164613685	188487	None	0	Human	Binding	pKi	=	7.7	7.7	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4861655	188487	None	0	Human	Binding	pKi	=	7.7	7.7	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028207	188487	None	0	Human	Binding	pKi	=	7.7	7.7	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	15157138	99623	None	0	Human	Binding	pKi	=	7.7	7.7	-6	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	345	9	0	3	4.8	CCN(CC)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL284137	99623	None	0	Human	Binding	pKi	=	7.7	7.7	-6	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	345	9	0	3	4.8	CCN(CC)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	155557119	176509	None	0	Human	Binding	pKi	=	7.7	7.7	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4555411	176509	None	0	Human	Binding	pKi	=	7.7	7.7	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4596899	176509	None	0	Human	Binding	pKi	=	7.7	7.7	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	155557119	176509	None	0	Human	Binding	pKi	=	7.7	7.7	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4555411	176509	None	0	Human	Binding	pKi	=	7.7	7.7	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596899	176509	None	0	Human	Binding	pKi	=	7.7	7.7	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	10155850	96740	None	0	Human	Binding	pKi	=	7.7	7.7	-9	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL264414	96740	None	0	Human	Binding	pKi	=	7.7	7.7	-9	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	44627860	14033	None	0	Human	Binding	pKi	=	7.7	7.7	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197371	14033	None	0	Human	Binding	pKi	=	7.7	7.7	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL568870	14033	None	0	Human	Binding	pKi	=	7.7	7.7	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	10789183	104365	None	0	Human	Binding	pKi	=	7.7	7.7	-25	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL310132	104365	None	0	Human	Binding	pKi	=	7.7	7.7	-25	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319009	106934	None	0	Human	Binding	pKi	=	7.7	7.7	-15	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL314831	106934	None	0	Human	Binding	pKi	=	7.7	7.7	-15	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44318782	206131	None	0	Human	Binding	pKi	=	7.7	7.7	-63	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85996	206131	None	0	Human	Binding	pKi	=	7.7	7.7	-63	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	154734599	2501	None	12	Rat	Binding	pKi	=	7.7	7.7	-1	12	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	327	2501	None	12	Rat	Binding	pKi	=	7.7	7.7	-1	12	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	4108	2501	None	12	Rat	Binding	pKi	=	7.7	7.7	-1	12	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	CHEMBL27673	2501	None	12	Rat	Binding	pKi	=	7.7	7.7	-1	12	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	44318851	104724	None	0	Human	Binding	pKi	=	6.7	6.7	-3	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	CHEMBL310558	104724	None	0	Human	Binding	pKi	=	6.7	6.7	-3	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	164608958	188458	None	0	Human	Binding	pKi	=	6.7	6.7	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4846447	188458	None	0	Human	Binding	pKi	=	6.7	6.7	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5027936	188458	None	0	Human	Binding	pKi	=	6.7	6.7	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	14964511	12099	None	0	Rat	Binding	pKi	=	5.7	5.7	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL1183954	12099	None	0	Rat	Binding	pKi	=	5.7	5.7	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL325473	12099	None	0	Rat	Binding	pKi	=	5.7	5.7	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	10465050	36185	None	2	Human	Binding	pKi	=	5.7	5.7	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2ccccn2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL144493	36185	None	2	Human	Binding	pKi	=	5.7	5.7	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2ccccn2)C2CCN1CC2	10.1021/jm00003a011
	162353393	179437	None	0	Human	Binding	pKi	=	5.7	5.7	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	CHEMBL4740422	179437	None	0	Human	Binding	pKi	=	5.7	5.7	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	137661377	159207	None	0	Human	Binding	pKi	=	5.7	5.7	-363	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	314	6	0	2	3.9	CCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4098720	159207	None	0	Human	Binding	pKi	=	5.7	5.7	-363	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	314	6	0	2	3.9	CCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	24894630	188967	None	0	Human	Binding	pKi	=	5.7	5.7	2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL508347	188967	None	0	Human	Binding	pKi	=	5.7	5.7	2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL555475	188967	None	0	Human	Binding	pKi	=	5.7	5.7	2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
	156016047	178258	None	0	Human	Binding	pKi	=	5.7	5.7	-1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4647816	178258	None	0	Human	Binding	pKi	=	5.7	5.7	-1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650722	178258	None	0	Human	Binding	pKi	=	5.7	5.7	-1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	44267758	12378	None	0	Human	Binding	pKi	=	6.7	6.7	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	470	6	0	3	6.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11856	12378	None	0	Human	Binding	pKi	=	6.7	6.7	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	470	6	0	3	6.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44400218	67627	None	0	Rat	Binding	pKi	=	5.7	5.7	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	383	6	1	5	2.6	COc1ccc(C(O)(C(=O)OCC#CCN2CC3CC3C2)C2CCCC2)cc1	10.1016/j.bmcl.2005.02.036
	CHEMBL190459	67627	None	0	Rat	Binding	pKi	=	5.7	5.7	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	383	6	1	5	2.6	COc1ccc(C(O)(C(=O)OCC#CCN2CC3CC3C2)C2CCCC2)cc1	10.1016/j.bmcl.2005.02.036
	73352415	92536	None	0	Human	Binding	pKi	=	5.7	5.7	1	4	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	293	4	0	2	2.5	CN(CCc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432044	92536	None	0	Human	Binding	pKi	=	5.7	5.7	1	4	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	293	4	0	2	2.5	CN(CCc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	44593622	187794	None	0	Human	Binding	pKi	=	6.7	6.7	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL495888	187794	None	0	Human	Binding	pKi	=	6.7	6.7	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL556390	187794	None	0	Human	Binding	pKi	=	6.7	6.7	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	156015809	178316	None	0	Human	Binding	pKi	=	6.7	6.7	5	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4645019	178316	None	0	Human	Binding	pKi	=	6.7	6.7	5	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651096	178316	None	0	Human	Binding	pKi	=	6.7	6.7	5	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	11833737	120337	None	0	Human	Binding	pKi	=	5.7	5.7	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	CHEMBL352966	120337	None	0	Human	Binding	pKi	=	5.7	5.7	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	73347725	92268	None	0	Human	Binding	pKi	=	5.7	5.7	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426674	92268	None	0	Human	Binding	pKi	=	5.7	5.7	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
	24894633	176898	None	0	Human	Binding	pKi	=	4.7	4.7	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@H]2CCCN2C)o1	10.1021/jm800145d
	CHEMBL461709	176898	None	0	Human	Binding	pKi	=	4.7	4.7	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@H]2CCCN2C)o1	10.1021/jm800145d
	73355415	92531	None	0	Human	Binding	pKi	=	6.7	6.7	1	13	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	277	3	1	1	2.1	C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42	10.1016/j.bmc.2013.07.045
	CHEMBL2432039	92531	None	0	Human	Binding	pKi	=	6.7	6.7	1	13	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	277	3	1	1	2.1	C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42	10.1016/j.bmc.2013.07.045
	10852782	168278	None	0	Rat	Binding	pKi	=	5.7	5.7	1	2	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	314	3	1	3	3.0	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCC1	10.1021/jm970333f
	CHEMBL43398	168278	None	0	Rat	Binding	pKi	=	5.7	5.7	1	2	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	314	3	1	3	3.0	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCC1	10.1021/jm970333f
	5281825	107546	None	11	Rat	Binding	pKi	=	6.7	6.7	1	2	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00566-8
	CHEMBL318849	107546	None	11	Rat	Binding	pKi	=	6.7	6.7	1	2	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00566-8
	44329347	208086	None	0	Rat	Binding	pKi	=	6.7	6.7	1	2	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@@H]3C[C@@H]3CCCC[C@H]32)N1C	10.1016/s0960-894x(02)00566-8
	CHEMBL97765	208086	None	0	Rat	Binding	pKi	=	6.7	6.7	1	2	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@@H]3C[C@@H]3CCCC[C@H]32)N1C	10.1016/s0960-894x(02)00566-8
	11504244	106517	None	0	Human	Binding	pKi	=	6.7	6.7	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	60138185	106517	None	0	Human	Binding	pKi	=	6.7	6.7	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3121474	106517	None	0	Human	Binding	pKi	=	6.7	6.7	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3140249	106517	None	0	Human	Binding	pKi	=	6.7	6.7	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	3652	4095	None	79	Human	Binding	pKi	=	6.7	6.7	-18	18	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4095	None	79	Human	Binding	pKi	=	6.7	6.7	-18	18	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4095	None	79	Human	Binding	pKi	=	6.7	6.7	-18	18	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	6.7	6.7	-18	18	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4095	None	79	Human	Binding	pKi	=	6.7	6.7	-18	18	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	156010398	178234	None	0	Human	Binding	pKi	=	6.7	6.7	7	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4633895	178234	None	0	Human	Binding	pKi	=	6.7	6.7	7	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650561	178234	None	0	Human	Binding	pKi	=	6.7	6.7	7	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	156011112	178273	None	0	Human	Binding	pKi	=	6.7	6.7	4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4633679	178273	None	0	Human	Binding	pKi	=	6.7	6.7	4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650842	178273	None	0	Human	Binding	pKi	=	6.7	6.7	4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	145960427	161448	None	0	Human	Binding	pKi	=	6.7	6.7	-1	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4127428	161448	None	0	Human	Binding	pKi	=	6.7	6.7	-1	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	42853214	206452	None	0	Human	Binding	pKi	=	6.7	6.7	-7	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	376	5	0	3	5.1	O=C(c1cccs1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL88078	206452	None	0	Human	Binding	pKi	=	6.7	6.7	-7	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	376	5	0	3	5.1	O=C(c1cccs1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	25025581	201994	None	0	Human	Binding	pKi	=	6.7	6.7	-3	8	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	285	4	1	2	3.1	CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1	10.1021/jm901818u
	CHEMBL608151	201994	None	0	Human	Binding	pKi	=	6.7	6.7	-3	8	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	285	4	1	2	3.1	CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1	10.1021/jm901818u
	10663237	147225	None	0	Rat	Binding	pKi	=	5.7	5.7	-	1	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	316	5	1	3	3.3	CCN(CC)CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm970333f
	CHEMBL39284	147225	None	0	Rat	Binding	pKi	=	5.7	5.7	-	1	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	316	5	1	3	3.3	CCN(CC)CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm970333f
	71459909	78613	None	0	Human	Binding	pKi	=	5.7	5.7	-3	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	444	5	0	3	6.4	O=C(c1cccs1)N(c1c(Cl)cccc1Cl)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL2112313	78613	None	0	Human	Binding	pKi	=	5.7	5.7	-3	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	444	5	0	3	6.4	O=C(c1cccs1)N(c1c(Cl)cccc1Cl)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	73350846	92264	None	0	Human	Binding	pKi	=	4.7	4.7	1	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426670	92264	None	0	Human	Binding	pKi	=	4.7	4.7	1	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	46227455	14168	None	0	Human	Binding	pKi	=	4.7	4.7	4	2	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL1198609	14168	None	0	Human	Binding	pKi	=	4.7	4.7	4	2	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL608985	14168	None	0	Human	Binding	pKi	=	4.7	4.7	4	2	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
	44406573	72972	None	0	Human	Binding	pKi	=	8.7	8.7	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200693	72972	None	0	Human	Binding	pKi	=	8.7	8.7	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406690	74991	None	0	Human	Binding	pKi	=	8.7	8.7	-1	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cncnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL203249	74991	None	0	Human	Binding	pKi	=	8.7	8.7	-1	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cncnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	9871871	120756	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	7	0	8	2.9	CCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL355169	120756	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	7	0	8	2.9	CCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	9843814	127247	None	0	Rat	Binding	pKi	=	8.7	8.7	25	2	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	CHEMBL36583	127247	None	0	Rat	Binding	pKi	=	8.7	8.7	25	2	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	44431383	88020	None	0	Human	Binding	pKi	=	8.7	8.7	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234439	88020	None	0	Human	Binding	pKi	=	8.7	8.7	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	16125370	84644	None	0	Human	Binding	pKi	=	8.7	8.7	-2	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	5.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL222387	84644	None	0	Human	Binding	pKi	=	8.7	8.7	-2	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	5.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCCN(Cc2ccccc2)CC1	10.1021/jm061159a
	155522355	176407	None	0	Human	Binding	pKi	=	8.7	8.7	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176407	None	0	Human	Binding	pKi	=	8.7	8.7	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176407	None	0	Human	Binding	pKi	=	8.7	8.7	31	5	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	44295965	189578	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	515	6	1	3	5.7	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL51459	189578	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	515	6	1	3	5.7	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	10470	2486	None	7	Human	Binding	pKi	=	8.7	8.7	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	1689	2486	None	7	Human	Binding	pKi	=	8.7	8.7	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	4057	2486	None	7	Human	Binding	pKi	=	8.7	8.7	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	CHEMBL524004	2486	None	7	Human	Binding	pKi	=	8.7	8.7	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	DB04843	2486	None	7	Human	Binding	pKi	=	8.7	8.7	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	140844422	176439	None	0	Human	Binding	pKi	=	8.7	8.7	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4452706	176439	None	0	Human	Binding	pKi	=	8.7	8.7	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596309	176439	None	0	Human	Binding	pKi	=	8.7	8.7	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	10104167	2057	None	2	Human	Binding	pKi	=	8.7	8.7	13	4	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	6937	2057	None	2	Human	Binding	pKi	=	8.7	8.7	13	4	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	CHEMBL3121473	2057	None	2	Human	Binding	pKi	=	8.7	8.7	13	4	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	44311704	204199	None	0	Human	Binding	pKi	=	8.7	8.7	53	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL70848	204199	None	0	Human	Binding	pKi	=	8.7	8.7	53	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311704	204199	None	0	Human	Binding	pKi	=	8.7	8.7	53	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL70848	204199	None	0	Human	Binding	pKi	=	8.7	8.7	53	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	688566	195881	None	24	Rat	Binding	pKi	=	8.7	8.7	-1	3	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	CHEMBL558910	195881	None	24	Rat	Binding	pKi	=	8.7	8.7	-1	3	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	10107360	78905	None	28	Rat	Binding	pKi	=	8.7	8.7	-	1	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	273	5	0	5	2.7	CN1CCC=C(c2nsnc2SCCCF)C1	10.1021/jm00001a002
	CHEMBL2112939	78905	None	28	Rat	Binding	pKi	=	8.7	8.7	-	1	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	273	5	0	5	2.7	CN1CCC=C(c2nsnc2SCCCF)C1	10.1021/jm00001a002
	164614388	188495	None	0	Human	Binding	pKi	=	8.6	8.6	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4848683	188495	None	0	Human	Binding	pKi	=	8.6	8.6	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028251	188495	None	0	Human	Binding	pKi	=	8.6	8.6	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44343736	110584	None	0	Rat	Binding	pKi	=	8.6	8.6	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6c(Cl)cccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL325451	110584	None	0	Rat	Binding	pKi	=	8.6	8.6	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6c(Cl)cccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	134272561	176425	None	0	Human	Binding	pKi	=	8.6	8.6	-2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4540604	176425	None	0	Human	Binding	pKi	=	8.6	8.6	-2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596189	176425	None	0	Human	Binding	pKi	=	8.6	8.6	-2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	44627858	14036	None	0	Human	Binding	pKi	=	8.6	8.6	-3	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197382	14036	None	0	Human	Binding	pKi	=	8.6	8.6	-3	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569307	14036	None	0	Human	Binding	pKi	=	8.6	8.6	-3	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	16125642	142008	None	0	Human	Binding	pKi	=	8.6	8.6	-2	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL387546	142008	None	0	Human	Binding	pKi	=	8.6	8.6	-2	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	154734599	2501	None	12	Human	Binding	pKi	=	8.6	8.6	1	12	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
	327	2501	None	12	Human	Binding	pKi	=	8.6	8.6	1	12	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
	4108	2501	None	12	Human	Binding	pKi	=	8.6	8.6	1	12	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	8.6	8.6	1	12	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
	14939891	169362	None	0	Rat	Binding	pKi	=	8.6	8.6	-3	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL442014	169362	None	0	Rat	Binding	pKi	=	8.6	8.6	-3	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44296054	189154	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	573	6	1	5	5.3	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL51096	189154	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	573	6	1	5	5.3	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	10119364	43248	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL150624	43248	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	44431381	149019	None	0	Human	Binding	pKi	=	8.6	8.6	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL394254	149019	None	0	Human	Binding	pKi	=	8.6	8.6	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	164616974	188516	None	0	Human	Binding	pKi	=	8.6	8.6	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4857722	188516	None	0	Human	Binding	pKi	=	8.6	8.6	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028407	188516	None	0	Human	Binding	pKi	=	8.6	8.6	9	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44378765	56542	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	542	6	1	7	3.5	CCNC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	CHEMBL163887	56542	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	542	6	1	7	3.5	CCNC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	44344030	10151	None	0	Rat	Binding	pKi	=	8.6	8.6	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	588	7	0	6	5.4	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL115807	10151	None	0	Rat	Binding	pKi	=	8.6	8.6	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	588	7	0	6	5.4	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	174174	523	None	49	Human	Binding	pKi	=	8.6	8.6	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	523	None	49	Human	Binding	pKi	=	8.6	8.6	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	523	None	49	Human	Binding	pKi	=	8.6	8.6	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.6	8.6	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	523	None	49	Human	Binding	pKi	=	8.6	8.6	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	10104167	2057	None	2	Human	Binding	pKi	=	8.6	8.6	13	4	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	6937	2057	None	2	Human	Binding	pKi	=	8.6	8.6	13	4	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	CHEMBL3121473	2057	None	2	Human	Binding	pKi	=	8.6	8.6	13	4	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	10109563	158538	None	0	Human	Binding	pKi	=	8.6	8.6	-7	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL409151	158538	None	0	Human	Binding	pKi	=	8.6	8.6	-7	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	16094788	141913	None	0	Human	Binding	pKi	=	8.6	8.6	5	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL386983	141913	None	0	Human	Binding	pKi	=	8.6	8.6	5	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	10606253	157271	None	0	Rat	Binding	pKi	=	8.6	8.6	1	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL407678	157271	None	0	Rat	Binding	pKi	=	8.6	8.6	1	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	13981865	112810	None	2	Human	Binding	pKi	=	8.6	8.6	11	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	CHEMBL3289391	112810	None	2	Human	Binding	pKi	=	8.6	8.6	11	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	CHEMBL3306998	112810	None	2	Human	Binding	pKi	=	8.6	8.6	11	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	1201549	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	333	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	7601	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	CHEMBL1201203	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	CHEMBL438151	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	DB00245	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	44378862	58117	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	7	0	6	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00024-0
	CHEMBL167629	58117	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	7	0	6	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00024-0
	16065268	67926	None	0	Human	Binding	pKi	=	8.6	8.6	-2	2	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	456	9	1	3	5.6	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CCC(Oc2ccccc2)CC1	10.1021/jm200884j
	CHEMBL1910849	67926	None	0	Human	Binding	pKi	=	8.6	8.6	-2	2	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	456	9	1	3	5.6	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CCC(Oc2ccccc2)CC1	10.1021/jm200884j
	155542840	176391	None	0	Human	Binding	pKi	=	8.6	8.6	-1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4521993	176391	None	0	Human	Binding	pKi	=	8.6	8.6	-1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4595947	176391	None	0	Human	Binding	pKi	=	8.6	8.6	-1	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	9815331	203105	None	1	Human	Binding	pKi	=	8.6	8.6	-1	8	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	CHEMBL64000	203105	None	1	Human	Binding	pKi	=	8.6	8.6	-1	8	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	9815331	203105	None	1	Rat	Binding	pKi	=	8.6	8.6	1	8	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203105	None	1	Rat	Binding	pKi	=	8.6	8.6	1	8	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	9815331	203105	None	1	Human	Binding	pKi	=	8.6	8.6	-1	8	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203105	None	1	Human	Binding	pKi	=	8.6	8.6	-1	8	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	9815331	203105	None	1	Human	Binding	pKi	=	8.6	8.6	-1	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1016/j.bmc.2007.12.036
	CHEMBL64000	203105	None	1	Human	Binding	pKi	=	8.6	8.6	-1	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1016/j.bmc.2007.12.036
	154417	93258	None	60	Rat	Binding	pKi	=	8.6	8.6	-10	9	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1016/j.bmcl.2007.12.051
	CHEMBL1331216	93258	None	60	Rat	Binding	pKi	=	8.6	8.6	-10	9	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1016/j.bmcl.2007.12.051
	CHEMBL2449003	93258	None	60	Rat	Binding	pKi	=	8.6	8.6	-10	9	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1016/j.bmcl.2007.12.051
	DB00424	93258	None	60	Rat	Binding	pKi	=	8.6	8.6	-10	9	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1016/j.bmcl.2007.12.051
	155538050	172347	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	550	6	0	4	6.0	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4475862	172347	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	550	6	0	4	6.0	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	44295618	165125	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1cccc(C(=O)N2CCC(N3CCC(C4(c5ccc(C(=O)NC(C)C)cc5)OCCO4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	CHEMBL422763	165125	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1cccc(C(=O)N2CCC(N3CCC(C4(c5ccc(C(=O)NC(C)C)cc5)OCCO4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	44267706	163247	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	574	10	0	6	6.5	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(OCC)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL418530	163247	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	574	10	0	6	6.5	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(OCC)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	10119364	43248	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL150624	43248	None	0	Human	Binding	pKi	=	8.6	8.6	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	9889312	78428	None	0	Human	Binding	pKi	=	8.6	8.6	2	5	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL2111540	78428	None	0	Human	Binding	pKi	=	8.6	8.6	2	5	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	2705	3840	None	64	Human	Binding	pKi	=	8.6	8.6	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
	360	3840	None	64	Human	Binding	pKi	=	8.6	8.6	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
	443879	3840	None	64	Human	Binding	pKi	=	8.6	8.6	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
	CHEMBL1382	3840	None	64	Human	Binding	pKi	=	8.6	8.6	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
	DB01036	3840	None	64	Human	Binding	pKi	=	8.6	8.6	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
	2705	3840	None	64	Rat	Binding	pKi	=	8.6	8.6	-1	10	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
	360	3840	None	64	Rat	Binding	pKi	=	8.6	8.6	-1	10	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
	443879	3840	None	64	Rat	Binding	pKi	=	8.6	8.6	-1	10	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
	CHEMBL1382	3840	None	64	Rat	Binding	pKi	=	8.6	8.6	-1	10	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
	DB01036	3840	None	64	Rat	Binding	pKi	=	8.6	8.6	-1	10	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
	16115796	137215	None	0	Human	Binding	pKi	=	8.6	8.6	-3	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL375073	137215	None	0	Human	Binding	pKi	=	8.6	8.6	-3	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	16115951	141641	None	0	Human	Binding	pKi	=	8.6	8.6	-3	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL385328	141641	None	0	Human	Binding	pKi	=	8.6	8.6	-3	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	12872437	12056	None	0	Rat	Binding	pKi	=	8.6	8.6	-2	5	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL1183585	12056	None	0	Rat	Binding	pKi	=	8.6	8.6	-2	5	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL306182	12056	None	0	Rat	Binding	pKi	=	8.6	8.6	-2	5	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	9889312	78428	None	0	Human	Binding	pKi	=	8.6	8.6	2	5	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2111540	78428	None	0	Human	Binding	pKi	=	8.6	8.6	2	5	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	154417	93258	None	60	Human	Binding	pKi	=	8.6	8.6	-18	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL1331216	93258	None	60	Human	Binding	pKi	=	8.6	8.6	-18	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL2449003	93258	None	60	Human	Binding	pKi	=	8.6	8.6	-18	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	DB00424	93258	None	60	Human	Binding	pKi	=	8.6	8.6	-18	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	118710664	120830	None	0	Human	Binding	pKi	=	8.6	8.6	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323281	120830	None	0	Human	Binding	pKi	=	8.6	8.6	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558231	120830	None	0	Human	Binding	pKi	=	8.6	8.6	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	118710664	120830	None	0	Human	Binding	pKi	=	8.6	8.6	1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323281	120830	None	0	Human	Binding	pKi	=	8.6	8.6	1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558231	120830	None	0	Human	Binding	pKi	=	8.6	8.6	1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	57326235	77183	None	0	Human	Binding	pKi	=	8.6	8.6	-5	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042405	77183	None	0	Human	Binding	pKi	=	8.6	8.6	-5	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2079009	77183	None	0	Human	Binding	pKi	=	8.6	8.6	-5	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	9871136	207113	None	0	Human	Binding	pKi	=	8.5	8.5	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	514	7	0	7	4.0	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL92110	207113	None	0	Human	Binding	pKi	=	8.5	8.5	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	514	7	0	7	4.0	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	164621814	188554	None	0	Human	Binding	pKi	=	8.5	8.5	22	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4867301	188554	None	0	Human	Binding	pKi	=	8.5	8.5	22	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028667	188554	None	0	Human	Binding	pKi	=	8.5	8.5	22	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44311835	204535	None	0	Human	Binding	pKi	=	8.5	8.5	31	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72787	204535	None	0	Human	Binding	pKi	=	8.5	8.5	31	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44311835	204535	None	0	Human	Binding	pKi	=	8.5	8.5	31	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72787	204535	None	0	Human	Binding	pKi	=	8.5	8.5	31	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44267725	11322	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11794	11322	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44267772	15792	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	465	6	1	4	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	CHEMBL12228	15792	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	465	6	1	4	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	10269504	134371	None	0	Human	Binding	pKi	=	7.7	7.7	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL371734	134371	None	0	Human	Binding	pKi	=	7.7	7.7	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406268	140794	None	0	Human	Binding	pKi	=	7.7	7.7	-19	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2ccc(F)cc2)c2ccc(F)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381878	140794	None	0	Human	Binding	pKi	=	7.7	7.7	-19	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2ccc(F)cc2)c2ccc(F)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44213237	101919	None	0	Human	Binding	pKi	=	7.7	7.7	-16	2	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL300998	101919	None	0	Human	Binding	pKi	=	7.7	7.7	-16	2	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	9889312	78428	None	0	Human	Binding	pKi	=	7.7	7.7	2	5	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL2111540	78428	None	0	Human	Binding	pKi	=	7.7	7.7	2	5	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	2551	793	None	23	Human	Binding	pKi	=	7.7	7.7	-6	11	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	298	793	None	23	Human	Binding	pKi	=	7.7	7.7	-6	11	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	488	793	None	23	Human	Binding	pKi	=	7.7	7.7	-6	11	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	CHEMBL965	793	None	23	Human	Binding	pKi	=	7.7	7.7	-6	11	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	DB00411	793	None	23	Human	Binding	pKi	=	7.7	7.7	-6	11	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	15050956	102926	None	0	Rat	Binding	pKi	=	7.7	7.7	3	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	552	8	1	7	3.4	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL306201	102926	None	0	Rat	Binding	pKi	=	7.7	7.7	3	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	552	8	1	7	3.4	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	2551	793	None	23	Rat	Binding	pKi	=	7.7	7.7	-3	11	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	793	None	23	Rat	Binding	pKi	=	7.7	7.7	-3	11	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	793	None	23	Rat	Binding	pKi	=	7.7	7.7	-3	11	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	793	None	23	Rat	Binding	pKi	=	7.7	7.7	-3	11	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	793	None	23	Rat	Binding	pKi	=	7.7	7.7	-3	11	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	2551	793	None	23	Human	Binding	pKi	=	7.7	7.7	-6	11	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	793	None	23	Human	Binding	pKi	=	7.7	7.7	-6	11	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	793	None	23	Human	Binding	pKi	=	7.7	7.7	-6	11	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	793	None	23	Human	Binding	pKi	=	7.7	7.7	-6	11	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	793	None	23	Human	Binding	pKi	=	7.7	7.7	-6	11	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	10557581	21772	None	0	Rat	Binding	pKi	=	7.7	7.7	-3	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202001	21772	None	0	Rat	Binding	pKi	=	7.7	7.7	-3	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL131913	21772	None	0	Rat	Binding	pKi	=	7.7	7.7	-3	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10398843	36405	None	0	Human	Binding	pKi	=	6.7	6.7	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	227	1	0	2	3.2	c1ccc2oc(C3CN4CCC3CC4)cc2c1	10.1021/jm00003a011
	CHEMBL144693	36405	None	0	Human	Binding	pKi	=	6.7	6.7	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	227	1	0	2	3.2	c1ccc2oc(C3CN4CCC3CC4)cc2c1	10.1021/jm00003a011
	137629935	161018	None	0	Human	Binding	pKi	=	5.7	5.7	1	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Binding	pKi	=	5.7	5.7	1	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Binding	pKi	=	5.7	5.7	1	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	10622033	42780	None	0	Human	Binding	pKi	=	5.7	5.7	-323	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
	CHEMBL150219	42780	None	0	Human	Binding	pKi	=	5.7	5.7	-323	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
	208598	35926	None	5	Human	Binding	pKi	=	4.7	4.7	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2ccccn2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL144247	35926	None	5	Human	Binding	pKi	=	4.7	4.7	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2ccccn2)CN2CCC1CC2	10.1021/jm00003a011
	6075	150106	None	42	Human	Binding	pKi	=	6.7	6.7	-7	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	CHEMBL395110	150106	None	42	Human	Binding	pKi	=	6.7	6.7	-7	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	16125529	137204	None	0	Human	Binding	pKi	=	5.7	5.7	-2	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL374987	137204	None	0	Human	Binding	pKi	=	5.7	5.7	-2	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	463892	31875	None	1	Human	Binding	pKi	=	6.7	6.7	-18	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	533	5	0	6	4.9	COc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
	CHEMBL140706	31875	None	1	Human	Binding	pKi	=	6.7	6.7	-18	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	533	5	0	6	4.9	COc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
	44392898	123086	None	0	Human	Binding	pKi	=	6.7	6.7	7	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	2	1	4	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C(O)=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL360988	123086	None	0	Human	Binding	pKi	=	6.7	6.7	7	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	2	1	4	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C(O)=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	71575027	86221	None	0	Human	Binding	pKi	=	5.7	5.7	-4	5	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	379	8	0	4	4.4	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	CHEMBL2312389	86221	None	0	Human	Binding	pKi	=	5.7	5.7	-4	5	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	379	8	0	4	4.4	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	463616	32048	None	1	Human	Binding	pKi	=	5.7	5.7	-2884	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	542	4	0	4	6.2	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)cncc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
	CHEMBL140827	32048	None	1	Human	Binding	pKi	=	5.7	5.7	-2884	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	542	4	0	4	6.2	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)cncc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
	2335	11846	None	22	Human	Binding	pKi	=	6.7	6.7	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	8478	11846	None	22	Human	Binding	pKi	=	6.7	6.7	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	CHEMBL1182210	11846	None	22	Human	Binding	pKi	=	6.7	6.7	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	CHEMBL221753	11846	None	22	Human	Binding	pKi	=	6.7	6.7	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	306	3454	None	21	Human	Binding	pKi	=	6.7	6.7	-8	5	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
	3536	3454	None	21	Human	Binding	pKi	=	6.7	6.7	-8	5	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
	53930639	3454	None	21	Human	Binding	pKi	=	6.7	6.7	-8	5	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
	9577995	3454	None	21	Human	Binding	pKi	=	6.7	6.7	-8	5	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
	CHEMBL134641	3454	None	21	Human	Binding	pKi	=	6.7	6.7	-8	5	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
	11504244	106517	None	0	Human	Binding	pKi	=	6.7	6.7	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	60138185	106517	None	0	Human	Binding	pKi	=	6.7	6.7	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3121474	106517	None	0	Human	Binding	pKi	=	6.7	6.7	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3140249	106517	None	0	Human	Binding	pKi	=	6.7	6.7	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	10236758	115770	None	5	Human	Binding	pKi	=	6.7	6.7	-208	13	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	328	7	0	2	4.3	CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/jm501173q
	CHEMBL3354065	115770	None	5	Human	Binding	pKi	=	6.7	6.7	-208	13	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	328	7	0	2	4.3	CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/jm501173q
	137655636	158734	None	0	Human	Binding	pKi	=	6.7	6.7	-95	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	376	7	0	2	4.7	O=C1CCc2ccccc2N1CCCN1CCC(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4093527	158734	None	0	Human	Binding	pKi	=	6.7	6.7	-95	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	376	7	0	2	4.7	O=C1CCc2ccccc2N1CCCN1CCC(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	44437249	11870	None	0	Human	Binding	pKi	=	5.7	5.7	2	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
	CHEMBL1182436	11870	None	0	Human	Binding	pKi	=	5.7	5.7	2	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
	CHEMBL238825	11870	None	0	Human	Binding	pKi	=	5.7	5.7	2	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
	137629935	161018	None	0	Human	Binding	pKi	=	5.7	5.7	1	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161018	None	0	Human	Binding	pKi	=	5.7	5.7	1	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161018	None	0	Human	Binding	pKi	=	5.7	5.7	1	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	16125372	84652	None	0	Human	Binding	pKi	=	6.7	6.7	-74	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	447	5	1	2	4.9	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL222424	84652	None	0	Human	Binding	pKi	=	6.7	6.7	-74	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	447	5	1	2	4.9	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	118719927	115779	None	0	Human	Binding	pKi	=	6.7	6.7	-2	8	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	386	11	1	3	4.4	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCO)CC1	10.1021/jm501173q
	CHEMBL3354074	115779	None	0	Human	Binding	pKi	=	6.7	6.7	-2	8	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	386	11	1	3	4.4	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCO)CC1	10.1021/jm501173q
	6603753	108700	None	1	Human	Binding	pKi	=	5.7	5.7	5	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	176	2	0	2	1.2	C[C@@H]1O[C@H](C[N+](C)(C)C)CS1	10.1016/j.bmc.2007.12.036
	CHEMBL320820	108700	None	1	Human	Binding	pKi	=	5.7	5.7	5	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	176	2	0	2	1.2	C[C@@H]1O[C@H](C[N+](C)(C)C)CS1	10.1016/j.bmc.2007.12.036
	44422692	11851	None	0	Human	Binding	pKi	=	5.7	5.7	5	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL1182296	11851	None	0	Human	Binding	pKi	=	5.7	5.7	5	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL228144	11851	None	0	Human	Binding	pKi	=	5.7	5.7	5	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	24865895	96003	None	0	Human	Binding	pKi	=	5.7	5.7	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	CHEMBL259662	96003	None	0	Human	Binding	pKi	=	5.7	5.7	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	CHEMBL390842	96003	None	0	Human	Binding	pKi	=	5.7	5.7	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	44383595	166113	None	0	Human	Binding	pKi	=	6.7	6.7	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	5	0	3	5.0	CCC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
	CHEMBL426032	166113	None	0	Human	Binding	pKi	=	6.7	6.7	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	5	0	3	5.0	CCC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
	10476118	123825	None	0	Rat	Binding	pKi	=	5.7	5.7	-4	2	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	400	4	0	3	3.2	CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1CCc1ccccc12	10.1016/S0960-894X(97)00143-1
	CHEMBL362438	123825	None	0	Rat	Binding	pKi	=	5.7	5.7	-4	2	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	400	4	0	3	3.2	CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1CCc1ccccc12	10.1016/S0960-894X(97)00143-1
	134271233	176537	None	0	Human	Binding	pKi	=	7.7	7.7	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4591883	176537	None	0	Human	Binding	pKi	=	7.7	7.7	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597134	176537	None	0	Human	Binding	pKi	=	7.7	7.7	3	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	118710664	120830	None	0	Human	Binding	pKi	=	7.7	7.7	1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323281	120830	None	0	Human	Binding	pKi	=	7.7	7.7	1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558231	120830	None	0	Human	Binding	pKi	=	7.7	7.7	1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	164622170	188558	None	0	Human	Binding	pKi	=	7.7	7.7	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4863723	188558	None	0	Human	Binding	pKi	=	7.7	7.7	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028687	188558	None	0	Human	Binding	pKi	=	7.7	7.7	7	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44593626	187851	None	0	Human	Binding	pKi	=	7.7	7.7	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496306	187851	None	0	Human	Binding	pKi	=	7.7	7.7	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539121	187851	None	0	Human	Binding	pKi	=	7.7	7.7	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	15050953	102337	None	0	Rat	Binding	pKi	=	7.7	7.7	1	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	536	9	2	7	4.0	CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL303684	102337	None	0	Rat	Binding	pKi	=	7.7	7.7	1	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	536	9	2	7	4.0	CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	101676031	97326	None	0	Rat	Binding	pKi	=	7.7	7.7	-4	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	16175987	97326	None	0	Rat	Binding	pKi	=	7.7	7.7	-4	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201998	97326	None	0	Rat	Binding	pKi	=	7.7	7.7	-4	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL269272	97326	None	0	Rat	Binding	pKi	=	7.7	7.7	-4	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	16664965	84900	None	0	Human	Binding	pKi	=	7.7	7.7	-28	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL223668	84900	None	0	Human	Binding	pKi	=	7.7	7.7	-28	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	44308733	102188	None	0	Human	Binding	pKi	=	6.7	6.7	-138	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	5	2	3	3.3	CC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL302809	102188	None	0	Human	Binding	pKi	=	6.7	6.7	-138	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	5	2	3	3.3	CC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	611037	203692	None	1	Rat	Binding	pKi	=	6.7	6.7	-3	4	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	399	4	1	5	2.2	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCl)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL67532	203692	None	1	Rat	Binding	pKi	=	6.7	6.7	-3	4	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	399	4	1	5	2.2	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCl)CC2)c2ccccc21	10.1021/jm00111a032
	14956862	13733	None	0	Rat	Binding	pKi	=	5.7	5.7	-10	2	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
	CHEMBL1195116	13733	None	0	Rat	Binding	pKi	=	5.7	5.7	-10	2	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
	CHEMBL553865	13733	None	0	Rat	Binding	pKi	=	5.7	5.7	-10	2	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
	14964513	11417	None	0	Rat	Binding	pKi	=	4.7	4.7	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL1180268	11417	None	0	Rat	Binding	pKi	=	4.7	4.7	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL119508	11417	None	0	Rat	Binding	pKi	=	4.7	4.7	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	14964497	14289	None	0	Rat	Binding	pKi	=	4.7	4.7	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119985	14289	None	0	Rat	Binding	pKi	=	4.7	4.7	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	10622718	38400	None	0	Human	Binding	pKi	=	4.7	4.7	-1174	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	3	4.5	O=C(NC1CCN(CC2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL146359	38400	None	0	Human	Binding	pKi	=	4.7	4.7	-1174	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	3	4.5	O=C(NC1CCN(CC2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	15086397	13718	None	0	Rat	Binding	pKi	=	6.7	6.7	-26	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1195036	13718	None	0	Rat	Binding	pKi	=	6.7	6.7	-26	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL553755	13718	None	0	Rat	Binding	pKi	=	6.7	6.7	-26	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
	3652	4095	None	79	Human	Binding	pKi	=	6.7	6.7	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4095	None	79	Human	Binding	pKi	=	6.7	6.7	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4095	None	79	Human	Binding	pKi	=	6.7	6.7	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	6.7	6.7	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4095	None	79	Human	Binding	pKi	=	6.7	6.7	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	118719928	115780	None	0	Human	Binding	pKi	=	6.7	6.7	-1	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	414	13	1	3	5.2	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCO)CC1	10.1021/jm501173q
	CHEMBL3354075	115780	None	0	Human	Binding	pKi	=	6.7	6.7	-1	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	414	13	1	3	5.2	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCO)CC1	10.1021/jm501173q
	156013536	178309	None	0	Human	Binding	pKi	=	5.7	5.7	-3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4639297	178309	None	0	Human	Binding	pKi	=	5.7	5.7	-3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651058	178309	None	0	Human	Binding	pKi	=	5.7	5.7	-3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	108993439	179858	None	1	Human	Binding	pKi	=	4.7	4.7	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	CC1Cc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4745429	179858	None	1	Human	Binding	pKi	=	4.7	4.7	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	CC1Cc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	71452382	83792	None	0	Human	Binding	pKi	=	6.7	6.7	-6	10	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205812	83792	None	0	Human	Binding	pKi	=	6.7	6.7	-6	10	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	44593617	187429	None	0	Human	Binding	pKi	=	6.7	6.7	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493795	187429	None	0	Human	Binding	pKi	=	6.7	6.7	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	11048067	5577	None	0	Human	Binding	pKi	=	6.7	6.7	-1	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.6	CCOC(=O)c1c(C)n(CC)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL107679	5577	None	0	Human	Binding	pKi	=	6.7	6.7	-1	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.6	CCOC(=O)c1c(C)n(CC)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	135430667	4956	None	0	Human	Binding	pKi	=	5.7	5.7	-35	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	402	2	1	6	4.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(-c5nc(C)no5)c34)OC21	10.1021/jm011116o
	CHEMBL104803	4956	None	0	Human	Binding	pKi	=	5.7	5.7	-35	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	402	2	1	6	4.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(-c5nc(C)no5)c34)OC21	10.1021/jm011116o
	11143997	5020	None	0	Human	Binding	pKi	=	5.7	5.7	-309	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	408	3	1	5	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	CHEMBL105122	5020	None	0	Human	Binding	pKi	=	5.7	5.7	-309	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	408	3	1	5	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	10225881	107619	None	0	Human	Binding	pKi	=	5.7	5.7	-724	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	6	1	5	5.9	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	CHEMBL318995	107619	None	0	Human	Binding	pKi	=	5.7	5.7	-724	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	6	1	5	5.9	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	58438451	92283	None	0	Human	Binding	pKi	=	4.7	4.7	-2089	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426689	92283	None	0	Human	Binding	pKi	=	4.7	4.7	-2089	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	44437298	11885	None	0	Human	Binding	pKi	=	6.7	6.7	7	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
	CHEMBL1182460	11885	None	0	Human	Binding	pKi	=	6.7	6.7	7	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
	CHEMBL239436	11885	None	0	Human	Binding	pKi	=	6.7	6.7	7	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
	9998202	69164	None	0	Rat	Binding	pKi	=	7.7	7.7	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL192485	69164	None	0	Rat	Binding	pKi	=	7.7	7.7	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	44267749	12946	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(F)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11893	12946	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(F)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44267693	169182	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL440601	169182	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	11595794	135699	None	0	Rat	Binding	pKi	=	7.7	7.7	-3	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
	CHEMBL372983	135699	None	0	Rat	Binding	pKi	=	7.7	7.7	-3	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
	44313630	204817	None	0	Human	Binding	pKi	=	7.7	7.7	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	401	9	0	4	5.1	CCN(CC)CCOCOC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	CHEMBL75217	204817	None	0	Human	Binding	pKi	=	7.7	7.7	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	401	9	0	4	5.1	CCN(CC)CCOCOC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	10525412	41972	None	0	Human	Binding	pKi	=	7.7	7.7	-6	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cc1	10.1021/jm0003135
	CHEMBL149486	41972	None	0	Human	Binding	pKi	=	7.7	7.7	-6	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cc1	10.1021/jm0003135
	15050961	203820	None	0	Rat	Binding	pKi	=	7.7	7.7	-6	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	612	16	2	7	5.8	COc1ccccc1CNCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL68446	203820	None	0	Rat	Binding	pKi	=	7.7	7.7	-6	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	612	16	2	7	5.8	COc1ccccc1CNCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	155525065	176552	None	0	Human	Binding	pKi	=	7.6	7.6	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4456524	176552	None	0	Human	Binding	pKi	=	7.6	7.6	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597243	176552	None	0	Human	Binding	pKi	=	7.6	7.6	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	1935	3732	None	97	Mouse	Binding	pKi	=	6.7	6.7	-6	6	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	2551	3732	None	97	Mouse	Binding	pKi	=	6.7	6.7	-6	6	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	6687	3732	None	97	Mouse	Binding	pKi	=	6.7	6.7	-6	6	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	CHEMBL95	3732	None	97	Mouse	Binding	pKi	=	6.7	6.7	-6	6	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	DB00382	3732	None	97	Mouse	Binding	pKi	=	6.7	6.7	-6	6	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	44568347	191649	None	0	Human	Binding	pKi	=	6.7	6.7	-10	15	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL519609	191649	None	0	Human	Binding	pKi	=	6.7	6.7	-10	15	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	155518181	170259	None	0	Human	Binding	pKi	=	6.7	6.7	-3	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	404	4	0	3	5.2	O=C(OCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	CHEMBL4446039	170259	None	0	Human	Binding	pKi	=	6.7	6.7	-3	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	404	4	0	3	5.2	O=C(OCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	16085999	80290	None	0	Human	Binding	pKi	=	6.7	6.7	-457	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	10	3	5	4.3	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL214029	80290	None	0	Human	Binding	pKi	=	6.7	6.7	-457	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	10	3	5	4.3	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	10646906	119231	None	0	Human	Binding	pKi	=	6.7	6.7	-63	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1	10.1021/jm0003135
	CHEMBL343449	119231	None	0	Human	Binding	pKi	=	6.7	6.7	-63	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1	10.1021/jm0003135
	44309089	103008	None	0	Human	Binding	pKi	=	5.7	5.7	-128	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	5	3	3	2.4	O=C(NCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL306903	103008	None	0	Human	Binding	pKi	=	5.7	5.7	-128	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	5	3	3	2.4	O=C(NCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	10061123	36888	None	0	Human	Binding	pKi	=	5.7	5.7	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2csc3ccccc23)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL145081	36888	None	0	Human	Binding	pKi	=	5.7	5.7	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2csc3ccccc23)CN2CCC1CC2	10.1021/jm00003a011
	44207909	16697	None	3	Human	Binding	pKi	=	5.7	5.7	-8	9	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	407	7	1	4	2.6	O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1	10.1021/jm100697g
	CHEMBL1242923	16697	None	3	Human	Binding	pKi	=	5.7	5.7	-8	9	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	407	7	1	4	2.6	O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1	10.1021/jm100697g
	44328540	207780	None	0	Human	Binding	pKi	=	5.7	5.7	-6	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	245	3	1	3	2.3	COc1ccccc1C(O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
	CHEMBL96042	207780	None	0	Human	Binding	pKi	=	5.7	5.7	-6	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	245	3	1	3	2.3	COc1ccccc1C(O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
	14964499	169387	None	3	Rat	Binding	pKi	=	4.7	4.7	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL442206	169387	None	3	Rat	Binding	pKi	=	4.7	4.7	-	1	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	137630043	161035	None	0	Human	Binding	pKi	=	4.7	4.7	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4099667	161035	None	0	Human	Binding	pKi	=	4.7	4.7	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116455	161035	None	0	Human	Binding	pKi	=	4.7	4.7	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44400185	69324	None	0	Rat	Binding	pKi	=	6.7	6.7	-1	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@@]3(C)C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	CHEMBL192885	69324	None	0	Rat	Binding	pKi	=	6.7	6.7	-1	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@@]3(C)C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	44295977	192729	None	0	Human	Binding	pKi	=	6.7	6.7	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
	CHEMBL52203	192729	None	0	Human	Binding	pKi	=	6.7	6.7	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
	1273944	202593	None	20	Human	Binding	pKi	=	5.7	5.7	-	1	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
	CHEMBL612034	202593	None	20	Human	Binding	pKi	=	5.7	5.7	-	1	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
	73352329	92263	None	0	Human	Binding	pKi	=	5.7	5.7	-1	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426669	92263	None	0	Human	Binding	pKi	=	5.7	5.7	-1	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	156015719	178256	None	0	Human	Binding	pKi	=	5.7	5.7	-4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4646457	178256	None	0	Human	Binding	pKi	=	5.7	5.7	-4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650699	178256	None	0	Human	Binding	pKi	=	5.7	5.7	-4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	156011605	178281	None	0	Human	Binding	pKi	=	5.7	5.7	1	3	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4638067	178281	None	0	Human	Binding	pKi	=	5.7	5.7	1	3	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650888	178281	None	0	Human	Binding	pKi	=	5.7	5.7	1	3	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	10101246	9544	None	0	Human	Binding	pKi	=	4.7	4.7	-81	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL112297	9544	None	0	Human	Binding	pKi	=	4.7	4.7	-81	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	9998202	69164	None	0	Rat	Binding	pKi	=	6.7	6.7	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL192485	69164	None	0	Rat	Binding	pKi	=	6.7	6.7	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	44382865	120279	None	0	Human	Binding	pKi	=	6.7	6.7	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	4	0	3	4.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(C)(C)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL352596	120279	None	0	Human	Binding	pKi	=	6.7	6.7	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	4	0	3	4.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(C)(C)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	16125620	84645	None	0	Human	Binding	pKi	=	6.7	6.7	-93	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	4.9	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	CHEMBL222388	84645	None	0	Human	Binding	pKi	=	6.7	6.7	-93	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	4.9	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	15105209	103617	None	1	Human	Binding	pKi	=	5.6	5.6	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	318	11	1	3	3.4	CCN(CC)CCOCCNCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL308707	103617	None	1	Human	Binding	pKi	=	5.6	5.6	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	318	11	1	3	3.4	CCN(CC)CCOCCNCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	16125371	84757	None	0	Human	Binding	pKi	=	5.6	5.6	-28	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
	CHEMBL223017	84757	None	0	Human	Binding	pKi	=	5.6	5.6	-28	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
	53324553	56853	None	0	Human	Binding	pKi	=	5.6	5.6	-3	10	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
	CHEMBL1643900	56853	None	0	Human	Binding	pKi	=	5.6	5.6	-3	10	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
	53324553	56853	None	0	Human	Binding	pKi	=	5.6	5.6	-3	10	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
	CHEMBL1643900	56853	None	0	Human	Binding	pKi	=	5.6	5.6	-3	10	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
	11013666	59430	None	1	Human	Binding	pKi	=	6.6	6.6	-5	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	354	6	0	2	5.2	CN(C)CCC1=C(C(c2ccccc2)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL171102	59430	None	1	Human	Binding	pKi	=	6.6	6.6	-5	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	354	6	0	2	5.2	CN(C)CCC1=C(C(c2ccccc2)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	44593616	193212	None	0	Human	Binding	pKi	=	6.6	6.6	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL523518	193212	None	0	Human	Binding	pKi	=	6.6	6.6	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	162649767	180100	None	0	Human	Binding	pKi	=	5.6	5.6	2	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4748337	180100	None	0	Human	Binding	pKi	=	5.6	5.6	2	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	44448500	12332	None	0	Human	Binding	pKi	=	5.6	5.6	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1185248	12332	None	0	Human	Binding	pKi	=	5.6	5.6	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL402282	12332	None	0	Human	Binding	pKi	=	5.6	5.6	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	145961152	161589	None	0	Human	Binding	pKi	=	5.6	5.6	-1	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4129382	161589	None	0	Human	Binding	pKi	=	5.6	5.6	-1	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	162658112	181069	None	0	Human	Binding	pKi	=	4.6	4.6	-1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4759774	181069	None	0	Human	Binding	pKi	=	4.6	4.6	-1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	73347827	92542	None	0	Human	Binding	pKi	=	5.6	5.6	1	4	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	311	4	0	2	2.6	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432052	92542	None	0	Human	Binding	pKi	=	5.6	5.6	1	4	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	311	4	0	2	2.6	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	14964494	11955	None	1	Rat	Binding	pKi	=	7.6	7.6	2	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118292	11955	None	1	Rat	Binding	pKi	=	7.6	7.6	2	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL5287315	194377	None	0	Human	Binding	pKi	=	7.6	7.6	-12	3	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	460	8	1	3	6.5	C#CCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	1734	116	None	10	Human	Binding	pKi	=	7.6	7.6	-9	13	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	307	116	None	10	Human	Binding	pKi	=	7.6	7.6	-9	13	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	CHEMBL168067	116	None	10	Human	Binding	pKi	=	7.6	7.6	-9	13	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	214124	169689	None	2	Human	Binding	pKi	=	7.6	7.6	-5	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CCN(CC)CCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL443780	169689	None	2	Human	Binding	pKi	=	7.6	7.6	-5	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CCN(CC)CCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	164619478	188537	None	0	Human	Binding	pKi	=	7.6	7.6	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4872882	188537	None	0	Human	Binding	pKi	=	7.6	7.6	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028552	188537	None	0	Human	Binding	pKi	=	7.6	7.6	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	14210083	156710	None	1	Human	Binding	pKi	=	7.6	7.6	-	1	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	CHEMBL4070155	156710	None	1	Human	Binding	pKi	=	7.6	7.6	-	1	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	137629887	161008	None	0	Human	Binding	pKi	=	6.6	6.6	-3	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4065555	161008	None	0	Human	Binding	pKi	=	6.6	6.6	-3	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116259	161008	None	0	Human	Binding	pKi	=	6.6	6.6	-3	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	14964507	114353	None	1	Rat	Binding	pKi	=	5.6	5.6	-5	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL333107	114353	None	1	Rat	Binding	pKi	=	5.6	5.6	-5	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	2551	793	None	23	Rat	Binding	pKi	=	5.6	5.6	-3	11	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	298	793	None	23	Rat	Binding	pKi	=	5.6	5.6	-3	11	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	488	793	None	23	Rat	Binding	pKi	=	5.6	5.6	-3	11	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL965	793	None	23	Rat	Binding	pKi	=	5.6	5.6	-3	11	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	DB00411	793	None	23	Rat	Binding	pKi	=	5.6	5.6	-3	11	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	13326	1051	None	0	Human	Binding	pKi	=	5.6	5.6	-2	3	Displacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysisDisplacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysis	ChEMBL	321	3	2	6	2.7	CC1=CC(=NC(NC2=C(C=CC=C2)C3=NN=NN3)=N1)C(F)(F)F	10.1021/acs.jmedchem.2c01997
	167312460	1051	None	0	Human	Binding	pKi	=	5.6	5.6	-2	3	Displacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysisDisplacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysis	ChEMBL	321	3	2	6	2.7	CC1=CC(=NC(NC2=C(C=CC=C2)C3=NN=NN3)=N1)C(F)(F)F	10.1021/acs.jmedchem.2c01997
	CHEMBL5279691	1051	None	0	Human	Binding	pKi	=	5.6	5.6	-2	3	Displacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysisDisplacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysis	ChEMBL	321	3	2	6	2.7	CC1=CC(=NC(NC2=C(C=CC=C2)C3=NN=NN3)=N1)C(F)(F)F	10.1021/acs.jmedchem.2c01997
	10716120	38281	None	0	Human	Binding	pKi	=	5.6	5.6	-208	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@@H](F)C2)CC1	10.1021/jm0003135
	CHEMBL146249	38281	None	0	Human	Binding	pKi	=	5.6	5.6	-208	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@@H](F)C2)CC1	10.1021/jm0003135
	44364174	121983	None	0	Human	Binding	pKi	=	5.6	5.6	-128	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	400	7	3	4	3.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](O)C2)CC1	10.1021/jm0003135
	CHEMBL359220	121983	None	0	Human	Binding	pKi	=	5.6	5.6	-128	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	400	7	3	4	3.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](O)C2)CC1	10.1021/jm0003135
	2726	918	None	68	Human	Binding	pKi	=	6.6	6.6	-79	73	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	918	None	68	Human	Binding	pKi	=	6.6	6.6	-79	73	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	918	None	68	Human	Binding	pKi	=	6.6	6.6	-79	73	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	918	None	68	Human	Binding	pKi	=	6.6	6.6	-79	73	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	918	None	68	Human	Binding	pKi	=	6.6	6.6	-79	73	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	10880435	59057	None	0	Human	Binding	pKi	=	6.6	6.6	6	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL169494	59057	None	0	Human	Binding	pKi	=	6.6	6.6	6	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	11015312	5272	None	0	Human	Binding	pKi	=	5.6	5.6	-34	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.9	CCCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL106505	5272	None	0	Human	Binding	pKi	=	5.6	5.6	-34	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.9	CCCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	44448538	12417	None	0	Human	Binding	pKi	=	4.6	4.6	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1185855	12417	None	0	Human	Binding	pKi	=	4.6	4.6	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL436850	12417	None	0	Human	Binding	pKi	=	4.6	4.6	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	44267740	98320	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	500	7	0	4	6.4	COc1cccc(Cl)c1C(=O)N1CCC(N2CCC(Cc3ccc(SC(C)C)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
	CHEMBL274999	98320	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	500	7	0	4	6.4	COc1cccc(Cl)c1C(=O)N1CCC(N2CCC(Cc3ccc(SC(C)C)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
	1353	1909	None	93	Rat	Binding	pKi	=	6.6	6.6	-338	86	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
	3559	1909	None	93	Rat	Binding	pKi	=	6.6	6.6	-338	86	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
	86	1909	None	93	Rat	Binding	pKi	=	6.6	6.6	-338	86	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
	CHEMBL54	1909	None	93	Rat	Binding	pKi	=	6.6	6.6	-338	86	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
	DB00502	1909	None	93	Rat	Binding	pKi	=	6.6	6.6	-338	86	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
	155565286	176264	None	0	Human	Binding	pKi	=	6.6	6.6	1	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4579642	176264	None	0	Human	Binding	pKi	=	6.6	6.6	1	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595003	176264	None	0	Human	Binding	pKi	=	6.6	6.6	1	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	156012936	178294	None	0	Human	Binding	pKi	=	6.6	6.6	-3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4639004	178294	None	0	Human	Binding	pKi	=	6.6	6.6	-3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650969	178294	None	0	Human	Binding	pKi	=	6.6	6.6	-3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	11092603	4859	None	0	Human	Binding	pKi	=	6.6	6.6	-3	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	524	7	0	7	5.8	C=CCOC(=O)c1c(C)n(Cc2ccc(OC)cc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL104332	4859	None	0	Human	Binding	pKi	=	6.6	6.6	-3	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	524	7	0	7	5.8	C=CCOC(=O)c1c(C)n(Cc2ccc(OC)cc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	73355325	92265	None	0	Human	Binding	pKi	=	5.6	5.6	-1	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426671	92265	None	0	Human	Binding	pKi	=	5.6	5.6	-1	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	137642607	158516	None	0	Human	Binding	pKi	=	5.6	5.6	-1230	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	348	5	0	2	4.2	O=C1CCc2ccccc2N1CCCN1CCC(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4091231	158516	None	0	Human	Binding	pKi	=	5.6	5.6	-1230	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	348	5	0	2	4.2	O=C1CCc2ccccc2N1CCCN1CCC(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	9817231	158234	None	22	Human	Binding	pKi	=	4.6	4.6	-2	7	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
	CHEMBL4088272	158234	None	22	Human	Binding	pKi	=	4.6	4.6	-2	7	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
	10693031	120985	None	0	Human	Binding	pKi	=	7.6	7.6	-11	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	4	4.2	Cc1cc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cs1	10.1021/jm0003135
	CHEMBL356305	120985	None	0	Human	Binding	pKi	=	7.6	7.6	-11	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	4	4.2	Cc1cc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cs1	10.1021/jm0003135
	15678851	102671	None	0	Rat	Binding	pKi	=	7.6	7.6	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	478	11	2	6	3.6	NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL304582	102671	None	0	Rat	Binding	pKi	=	7.6	7.6	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	478	11	2	6	3.6	NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	15888010	203844	None	0	Human	Binding	pKi	=	6.6	6.6	-79	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.3	NC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL68584	203844	None	0	Human	Binding	pKi	=	6.6	6.6	-79	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.3	NC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	14964498	13885	None	0	Rat	Binding	pKi	=	6.6	6.6	6	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119615	13885	None	0	Rat	Binding	pKi	=	6.6	6.6	6	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	15050941	203665	None	0	Rat	Binding	pKi	=	6.6	6.6	-1	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	427	4	1	5	3.1	O=C1Nc2cccnc2N(C(=O)CN2CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL67381	203665	None	0	Rat	Binding	pKi	=	6.6	6.6	-1	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	427	4	1	5	3.1	O=C1Nc2cccnc2N(C(=O)CN2CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm00111a032
	2230	465	None	60	Human	Binding	pKi	=	5.6	5.6	-75	10	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
	296	465	None	60	Human	Binding	pKi	=	5.6	5.6	-75	10	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
	CHEMBL7303	465	None	60	Human	Binding	pKi	=	5.6	5.6	-75	10	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
	DB04365	465	None	60	Human	Binding	pKi	=	5.6	5.6	-75	10	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
	137630995	161139	None	0	Human	Binding	pKi	=	5.6	5.6	-14	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4102555	161139	None	0	Human	Binding	pKi	=	5.6	5.6	-14	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117268	161139	None	0	Human	Binding	pKi	=	5.6	5.6	-14	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44328347	207549	None	0	Human	Binding	pKi	=	5.6	5.6	-1	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	317	1	1	2	3.6	OC1(C2=CN3CCC2CC3)c2ccccc2CCc2ccccc21	10.1016/S0960-894X(01)80824-6
	CHEMBL94772	207549	None	0	Human	Binding	pKi	=	5.6	5.6	-1	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	317	1	1	2	3.6	OC1(C2=CN3CCC2CC3)c2ccccc2CCc2ccccc21	10.1016/S0960-894X(01)80824-6
	44318817	169112	None	0	Human	Binding	pKi	=	5.6	5.6	-7	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	CHEMBL440138	169112	None	0	Human	Binding	pKi	=	5.6	5.6	-7	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	10836338	39331	None	0	Human	Binding	pKi	=	5.6	5.6	-186	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	429	6	2	4	3.5	O=C(NC1CCN(Cc2ccccn2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL147105	39331	None	0	Human	Binding	pKi	=	5.6	5.6	-186	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	429	6	2	4	3.5	O=C(NC1CCN(Cc2ccccn2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	10573458	119260	None	0	Human	Binding	pKi	=	5.6	5.6	-218	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	407	6	2	4	3.5	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)n1	10.1021/jm0003135
	CHEMBL343659	119260	None	0	Human	Binding	pKi	=	5.6	5.6	-218	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	407	6	2	4	3.5	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)n1	10.1021/jm0003135
	14537192	100222	None	0	Rat	Binding	pKi	=	5.6	5.6	1	2	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL288482	100222	None	0	Rat	Binding	pKi	=	5.6	5.6	1	2	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	44267796	98099	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc5ccccc5c4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL273439	98099	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc5ccccc5c4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44326538	13264	None	0	Human	Binding	pKi	=	6.6	6.6	-1	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	9	0	3	4.3	CCN(CC)CCOC(=O)C(CC)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL1191560	13264	None	0	Human	Binding	pKi	=	6.6	6.6	-1	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	9	0	3	4.3	CCN(CC)CCOC(=O)C(CC)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	164622564	188559	None	0	Human	Binding	pKi	=	6.6	6.6	25	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4862221	188559	None	0	Human	Binding	pKi	=	6.6	6.6	25	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028706	188559	None	0	Human	Binding	pKi	=	6.6	6.6	25	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	2230	465	None	60	Human	Binding	pKi	=	5.6	5.6	-75	10	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	296	465	None	60	Human	Binding	pKi	=	5.6	5.6	-75	10	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	CHEMBL7303	465	None	60	Human	Binding	pKi	=	5.6	5.6	-75	10	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	DB04365	465	None	60	Human	Binding	pKi	=	5.6	5.6	-75	10	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	164614732	188496	None	0	Human	Binding	pKi	=	5.6	5.6	10	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4860752	188496	None	0	Human	Binding	pKi	=	5.6	5.6	10	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028266	188496	None	0	Human	Binding	pKi	=	5.6	5.6	10	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	162353371	181648	None	0	Human	Binding	pKi	=	5.6	5.6	2	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4775999	181648	None	0	Human	Binding	pKi	=	5.6	5.6	2	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	10916286	5100	None	0	Human	Binding	pKi	=	5.6	5.6	-1	4	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cccc(Cl)c2C1O3	10.1021/jm011116o
	CHEMBL105593	5100	None	0	Human	Binding	pKi	=	5.6	5.6	-1	4	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cccc(Cl)c2C1O3	10.1021/jm011116o
	15157141	92799	None	0	Human	Binding	pKi	=	6.6	6.6	-1	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	373	11	0	3	5.6	CCN(CC)CCCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL24369	92799	None	0	Human	Binding	pKi	=	6.6	6.6	-1	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	373	11	0	3	5.6	CCN(CC)CCCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	71449188	79683	None	0	Rat	Binding	pKi	=	5.6	5.6	1	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@H]1CCCN1	10.1021/jm00087a008
	CHEMBL2115359	79683	None	0	Rat	Binding	pKi	=	5.6	5.6	1	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@H]1CCCN1	10.1021/jm00087a008
	15157140	99872	None	0	Human	Binding	pKi	=	6.6	6.6	-2	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	359	10	0	3	5.2	CCN(CC)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL285898	99872	None	0	Human	Binding	pKi	=	6.6	6.6	-2	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	359	10	0	3	5.2	CCN(CC)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	1210	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	1213	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	2725	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	33036	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	4411	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	616	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	6976	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	716121	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL1201353	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL1554789	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL505	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	DB01114	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	DB13679	917	None	51	Human	Binding	pKi	=	5.6	5.6	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
	9880462	72902	None	0	Human	Binding	pKi	=	7.6	7.6	-39	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	327	5	1	3	3.2	CCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
	CHEMBL200416	72902	None	0	Human	Binding	pKi	=	7.6	7.6	-39	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	327	5	1	3	3.2	CCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
	9308	17752	None	21	Human	Binding	pKi	=	7.6	7.6	2	7	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL1255785	17752	None	21	Human	Binding	pKi	=	7.6	7.6	2	7	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL12587	17752	None	21	Human	Binding	pKi	=	7.6	7.6	2	7	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL292911	17752	None	21	Human	Binding	pKi	=	7.6	7.6	2	7	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	10066369	120256	None	0	Human	Binding	pKi	=	7.6	7.6	8	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL352375	120256	None	0	Human	Binding	pKi	=	7.6	7.6	8	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	10269504	134371	None	0	Human	Binding	pKi	=	7.6	7.6	-6	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL371734	134371	None	0	Human	Binding	pKi	=	7.6	7.6	-6	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	44319342	205716	None	0	Human	Binding	pKi	=	7.6	7.6	-31	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL82512	205716	None	0	Human	Binding	pKi	=	7.6	7.6	-31	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	511332	109626	None	5	Human	Binding	pKi	=	6.6	6.6	-35	3	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
	CHEMBL322251	109626	None	5	Human	Binding	pKi	=	6.6	6.6	-35	3	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
	44267694	12725	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	512	7	0	3	7.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4-c4ccccc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11877	12725	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	512	7	0	3	7.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4-c4ccccc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	511332	109626	None	5	Human	Binding	pKi	=	6.6	6.6	-35	3	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL322251	109626	None	5	Human	Binding	pKi	=	6.6	6.6	-35	3	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	135409468	2033	None	69	Human	Binding	pKi	=	6.6	6.6	-114	40	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
	333	2033	None	69	Human	Binding	pKi	=	6.6	6.6	-114	40	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
	CHEMBL845	2033	None	69	Human	Binding	pKi	=	6.6	6.6	-114	40	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
	464036	9744	None	4	Human	Binding	pKi	=	5.6	5.6	-1174	2	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
	CHEMBL113436	9744	None	4	Human	Binding	pKi	=	5.6	5.6	-1174	2	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
	14964506	113314	None	1	Rat	Binding	pKi	=	5.6	5.6	-6	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL331556	113314	None	1	Rat	Binding	pKi	=	5.6	5.6	-6	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	464036	9744	None	4	Human	Binding	pKi	=	5.6	5.6	-1174	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL113436	9744	None	4	Human	Binding	pKi	=	5.6	5.6	-1174	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	10012596	189012	None	2	Rat	Binding	pKi	=	5.6	5.6	1	2	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	CHEMBL50898	189012	None	2	Rat	Binding	pKi	=	5.6	5.6	1	2	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	1353	1909	None	93	Rat	Binding	pKi	=	5.6	5.6	-338	86	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	3559	1909	None	93	Rat	Binding	pKi	=	5.6	5.6	-338	86	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	86	1909	None	93	Rat	Binding	pKi	=	5.6	5.6	-338	86	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	CHEMBL54	1909	None	93	Rat	Binding	pKi	=	5.6	5.6	-338	86	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	DB00502	1909	None	93	Rat	Binding	pKi	=	5.6	5.6	-338	86	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	15050947	102595	None	0	Rat	Binding	pKi	=	5.6	5.6	-	1	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	613	8	3	8	3.4	CC(C)(C)OC(=O)NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	CHEMBL304109	102595	None	0	Rat	Binding	pKi	=	5.6	5.6	-	1	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	613	8	3	8	3.4	CC(C)(C)OC(=O)NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	44406572	72840	None	0	Human	Binding	pKi	=	6.6	6.6	-3	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200208	72840	None	0	Human	Binding	pKi	=	6.6	6.6	-3	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406346	136148	None	0	Human	Binding	pKi	=	6.6	6.6	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	361	4	1	3	3.2	COC1(C#CC(O)(Cc2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL373256	136148	None	0	Human	Binding	pKi	=	6.6	6.6	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	361	4	1	3	3.2	COC1(C#CC(O)(Cc2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	2200	3129	None	46	Human	Binding	pKi	=	6.6	6.6	-35	13	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
	328	3129	None	46	Human	Binding	pKi	=	6.6	6.6	-35	13	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
	4848	3129	None	46	Human	Binding	pKi	=	6.6	6.6	-35	13	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.6	6.6	-35	13	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
	DB00670	3129	None	46	Human	Binding	pKi	=	6.6	6.6	-35	13	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
	164611279	188471	None	0	Human	Binding	pKi	=	6.6	6.6	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854472	188471	None	0	Human	Binding	pKi	=	6.6	6.6	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028067	188471	None	0	Human	Binding	pKi	=	6.6	6.6	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44319010	205824	None	0	Human	Binding	pKi	=	6.6	6.6	-15	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	348	5	0	2	4.5	O=C(C1CCC1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83363	205824	None	0	Human	Binding	pKi	=	6.6	6.6	-15	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	348	5	0	2	4.5	O=C(C1CCC1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	50898777	56438	None	0	Human	Binding	pKi	=	5.6	5.6	-23442	8	Binding affinity to muscarinic acetylcholine receptor M2Binding affinity to muscarinic acetylcholine receptor M2	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
	CHEMBL1632158	56438	None	0	Human	Binding	pKi	=	5.6	5.6	-23442	8	Binding affinity to muscarinic acetylcholine receptor M2Binding affinity to muscarinic acetylcholine receptor M2	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
	15050950	204055	None	0	Rat	Binding	pKi	=	5.6	5.6	-3	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	5	2	6	1.1	CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL70003	204055	None	0	Rat	Binding	pKi	=	5.6	5.6	-3	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	5	2	6	1.1	CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	44267715	14542	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	438	6	0	5	4.5	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnccn4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12029	14542	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	438	6	0	5	4.5	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnccn4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	462989	33102	None	1	Human	Binding	pKi	=	6.6	6.6	-14	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1c[n+]([O-])cc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL141699	33102	None	1	Human	Binding	pKi	=	6.6	6.6	-14	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1c[n+]([O-])cc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	44267750	15246	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	6	0	5	5.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12112	15246	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	6	0	5	5.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44267697	16315	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cccnc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12268	16315	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cccnc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	11011757	59221	None	0	Human	Binding	pKi	=	6.6	6.6	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	291	5	0	1	4.8	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccc1	10.1021/jm020895l
	CHEMBL170221	59221	None	0	Human	Binding	pKi	=	6.6	6.6	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	291	5	0	1	4.8	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccc1	10.1021/jm020895l
	10104167	2057	None	2	Human	Binding	pKi	=	6.6	6.6	13	4	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	6937	2057	None	2	Human	Binding	pKi	=	6.6	6.6	13	4	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	CHEMBL3121473	2057	None	2	Human	Binding	pKi	=	6.6	6.6	13	4	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	44448496	11910	None	0	Human	Binding	pKi	=	4.6	4.6	-3	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182637	11910	None	0	Human	Binding	pKi	=	4.6	4.6	-3	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL257547	11910	None	0	Human	Binding	pKi	=	4.6	4.6	-3	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	15157139	99809	None	0	Human	Binding	pKi	=	6.6	6.6	-8	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CN(C)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL285440	99809	None	0	Human	Binding	pKi	=	6.6	6.6	-8	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CN(C)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	44267751	98384	None	0	Human	Binding	pKi	=	7.6	7.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	7	1	4	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Cc3ccc(SCCO)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
	CHEMBL275347	98384	None	0	Human	Binding	pKi	=	7.6	7.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	7	1	4	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Cc3ccc(SCCO)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
	154734599	2501	None	12	Human	Binding	pKi	=	7.6	7.6	1	12	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	327	2501	None	12	Human	Binding	pKi	=	7.6	7.6	1	12	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	4108	2501	None	12	Human	Binding	pKi	=	7.6	7.6	1	12	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	7.6	7.6	1	12	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	44383065	120378	None	0	Human	Binding	pKi	=	7.6	7.6	5	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	399	5	1	3	5.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCNC34CC5CC(CC(C5)C3)C4)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL353311	120378	None	0	Human	Binding	pKi	=	7.6	7.6	5	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	399	5	1	3	5.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCNC34CC5CC(CC(C5)C3)C4)[C@@H]12	10.1016/s0960-894x(99)00101-8
	44312152	204144	None	0	Human	Binding	pKi	=	7.6	7.6	2	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	374	6	1	5	2.2	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(CCO)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL70531	204144	None	0	Human	Binding	pKi	=	7.6	7.6	2	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	374	6	1	5	2.2	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(CCO)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL5268503	193565	None	0	Human	Binding	pKi	=	7.6	7.6	-10	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1038	20	1	13	9.7	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
	CHEMBL5283759	194226	None	0	Human	Binding	pKi	=	7.6	7.6	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1024	19	1	13	9.4	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
	15678850	103006	None	0	Rat	Binding	pKi	=	7.6	7.6	-1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	464	10	2	6	3.2	NCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL306875	103006	None	0	Rat	Binding	pKi	=	7.6	7.6	-1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	464	10	2	6	3.2	NCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	15157137	99893	None	0	Human	Binding	pKi	=	7.6	7.6	-17	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	317	7	0	3	4.0	CN(C)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL286008	99893	None	0	Human	Binding	pKi	=	7.6	7.6	-17	4	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	317	7	0	3	4.0	CN(C)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	71741394	120833	None	0	Human	Binding	pKi	=	7.6	7.6	-	1	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323287	120833	None	0	Human	Binding	pKi	=	7.6	7.6	-	1	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558239	120833	None	0	Human	Binding	pKi	=	7.6	7.6	-	1	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	44267799	16348	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	454	6	0	3	5.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4F)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12291	16348	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	454	6	0	3	5.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4F)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	14964499	169387	None	3	Rat	Binding	pKi	=	6.6	6.6	-	1	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL442206	169387	None	3	Rat	Binding	pKi	=	6.6	6.6	-	1	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	10421982	206039	None	0	Human	Binding	pKi	=	6.6	6.6	1	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
	CHEMBL85190	206039	None	0	Human	Binding	pKi	=	6.6	6.6	1	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
	10812455	39785	None	0	Human	Binding	pKi	=	6.6	6.6	-109	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	428	6	2	3	4.1	O=C(NC1CCN(Cc2ccccc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL147653	39785	None	0	Human	Binding	pKi	=	6.6	6.6	-109	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	428	6	2	3	4.1	O=C(NC1CCN(Cc2ccccc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	15196354	119268	None	0	Human	Binding	pKi	=	5.6	5.6	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
	CHEMBL343697	119268	None	0	Human	Binding	pKi	=	5.6	5.6	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
	23352285	96777	None	2	Human	Binding	pKi	=	5.6	5.6	-2	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	219	2	0	3	2.6	O=Cc1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
	CHEMBL264747	96777	None	2	Human	Binding	pKi	=	5.6	5.6	-2	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	219	2	0	3	2.6	O=Cc1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
	137628850	160967	None	0	Human	Binding	pKi	=	4.6	4.6	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4097248	160967	None	0	Human	Binding	pKi	=	4.6	4.6	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4115965	160967	None	0	Human	Binding	pKi	=	4.6	4.6	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
	10957754	59042	None	0	Human	Binding	pKi	=	6.6	6.6	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CC(C1=C(CCCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL169401	59042	None	0	Human	Binding	pKi	=	6.6	6.6	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CC(C1=C(CCCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	46905988 91930079	10414	None	0	Rat	Binding	pKi	=	5.6	5.6	-3	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	8	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(CCCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL1162964	10414	None	0	Rat	Binding	pKi	=	5.6	5.6	-3	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	8	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(CCCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	15050946	102644	None	0	Rat	Binding	pKi	=	5.6	5.6	1	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	484	5	2	6	2.5	CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	CHEMBL304391	102644	None	0	Rat	Binding	pKi	=	5.6	5.6	1	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	484	5	2	6	2.5	CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	1212	1660	None	50	Human	Binding	pKi	=	5.6	5.6	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1660	None	50	Human	Binding	pKi	=	5.6	5.6	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1660	None	50	Human	Binding	pKi	=	5.6	5.6	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1660	None	50	Human	Binding	pKi	=	5.6	5.6	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1660	None	50	Human	Binding	pKi	=	5.6	5.6	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	2200	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
	328	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
	4848	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
	DB00670	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
	2200	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
	328	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
	4848	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
	DB00670	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
	2200	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
	328	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
	4848	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
	DB00670	3129	None	46	Rat	Binding	pKi	=	6.6	6.6	-31	13	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
	13773340	79588	None	0	Rat	Binding	pKi	=	4.6	4.6	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2114396	79588	None	0	Rat	Binding	pKi	=	4.6	4.6	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	16125698	84554	None	0	Human	Binding	pKi	=	6.6	6.6	-102	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2ccccn2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222054	84554	None	0	Human	Binding	pKi	=	6.6	6.6	-102	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2ccccn2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	70682037	75879	None	20	Human	Binding	pKi	=	6.6	6.6	-43	2	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
	CHEMBL2048820	75879	None	20	Human	Binding	pKi	=	6.6	6.6	-43	2	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
	3652	4095	None	79	Human	Binding	pKi	=	6.6	6.6	-18	18	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	57	4095	None	79	Human	Binding	pKi	=	6.6	6.6	-18	18	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	60809	4095	None	79	Human	Binding	pKi	=	6.6	6.6	-18	18	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	6.6	6.6	-18	18	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	DB15357	4095	None	79	Human	Binding	pKi	=	6.6	6.6	-18	18	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	24894637	188717	None	0	Human	Binding	pKi	=	5.6	5.6	2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL504733	188717	None	0	Human	Binding	pKi	=	5.6	5.6	2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL553434	188717	None	0	Human	Binding	pKi	=	5.6	5.6	2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	44296020	194833	None	0	Human	Binding	pKi	=	7.6	7.6	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	487	6	2	4	4.3	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]cnc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL53965	194833	None	0	Human	Binding	pKi	=	7.6	7.6	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	487	6	2	4	4.3	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]cnc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	154734599	2501	None	12	Human	Binding	pKi	=	7.6	7.6	1	12	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
	327	2501	None	12	Human	Binding	pKi	=	7.6	7.6	1	12	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
	4108	2501	None	12	Human	Binding	pKi	=	7.6	7.6	1	12	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	7.6	7.6	1	12	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
	156578	141487	None	5	Rat	Binding	pKi	=	7.6	7.6	81	2	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	192	2	0	2	0.3	O=C1CCCN1CC#CCN1CCC1	10.1021/jm00087a008
	CHEMBL38441	141487	None	5	Rat	Binding	pKi	=	7.6	7.6	81	2	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	192	2	0	2	0.3	O=C1CCCN1CC#CCN1CCC1	10.1021/jm00087a008
	16125335	138156	None	0	Human	Binding	pKi	=	7.6	7.6	-4	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	454	6	1	2	4.3	C[N+]1(C[C@H]2O[C@@H]2c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL376900	138156	None	0	Human	Binding	pKi	=	7.6	7.6	-4	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	454	6	1	2	4.3	C[N+]1(C[C@H]2O[C@@H]2c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	462772	102309	None	1	Human	Binding	pKi	=	6.6	6.6	-5	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	643	6	0	7	5.9	C[C@H]1CN(C2CCN(C(=O)c3c(Cl)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	CHEMBL303503	102309	None	1	Human	Binding	pKi	=	6.6	6.6	-5	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	643	6	0	7	5.9	C[C@H]1CN(C2CCN(C(=O)c3c(Cl)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	44385809	61464	None	0	Human	Binding	pKi	=	6.6	6.6	-81	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL177040	61464	None	0	Human	Binding	pKi	=	6.6	6.6	-81	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	2200	3129	None	46	Human	Binding	pKi	=	6.6	6.6	-35	13	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
	328	3129	None	46	Human	Binding	pKi	=	6.6	6.6	-35	13	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
	4848	3129	None	46	Human	Binding	pKi	=	6.6	6.6	-35	13	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.6	6.6	-35	13	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
	DB00670	3129	None	46	Human	Binding	pKi	=	6.6	6.6	-35	13	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
	9991939	119350	None	0	Human	Binding	pKi	=	6.6	6.6	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2cc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL344327	119350	None	0	Human	Binding	pKi	=	6.6	6.6	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2cc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
	11796509	40695	None	0	Human	Binding	pKi	=	6.6	6.6	-45	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	422	7	2	4	3.9	COc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
	CHEMBL148450	40695	None	0	Human	Binding	pKi	=	6.6	6.6	-45	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	422	7	2	4	3.9	COc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
	10354430	37169	None	0	Human	Binding	pKi	=	5.6	5.6	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	243	1	1	3	2.3	OC1(c2cc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL145301	37169	None	0	Human	Binding	pKi	=	5.6	5.6	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	243	1	1	3	2.3	OC1(c2cc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
	9839491	163207	None	0	Rat	Binding	pKi	=	5.6	5.6	1	3	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
	CHEMBL41830	163207	None	0	Rat	Binding	pKi	=	5.6	5.6	1	3	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
	CHEMBL554874	163207	None	0	Rat	Binding	pKi	=	5.6	5.6	1	3	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
	10035281	100980	None	0	Human	Binding	pKi	=	5.6	5.6	-1	8	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	CHEMBL294273	100980	None	0	Human	Binding	pKi	=	5.6	5.6	-1	8	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	10035281	100980	None	0	Rat	Binding	pKi	=	5.6	5.6	-1	8	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
	CHEMBL294273	100980	None	0	Rat	Binding	pKi	=	5.6	5.6	-1	8	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
	10035281	100980	None	0	Human	Binding	pKi	=	5.6	5.6	-1	8	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
	CHEMBL294273	100980	None	0	Human	Binding	pKi	=	5.6	5.6	-1	8	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
	14964506	113314	None	1	Rat	Binding	pKi	=	4.6	4.6	-6	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL331556	113314	None	1	Rat	Binding	pKi	=	4.6	4.6	-6	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	15196232	165369	None	3	Human	Binding	pKi	=	4.6	4.6	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2cccnc2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL423746	165369	None	3	Human	Binding	pKi	=	4.6	4.6	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2cccnc2)CN2CCC1CC2	10.1021/jm00003a011
	137628858	160969	None	0	Human	Binding	pKi	=	4.6	4.6	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4074319	160969	None	0	Human	Binding	pKi	=	4.6	4.6	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115967	160969	None	0	Human	Binding	pKi	=	4.6	4.6	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	3055	1432	None	44	Human	Binding	pKi	=	6.6	6.6	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	313	1432	None	44	Human	Binding	pKi	=	6.6	6.6	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	7163	1432	None	44	Human	Binding	pKi	=	6.6	6.6	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	CHEMBL936	1432	None	44	Human	Binding	pKi	=	6.6	6.6	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	DB01231	1432	None	44	Human	Binding	pKi	=	6.6	6.6	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	44384258	128672	None	0	Human	Binding	pKi	=	6.6	6.6	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.6	CC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
	CHEMBL366819	128672	None	0	Human	Binding	pKi	=	6.6	6.6	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.6	CC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
	3652	4095	None	79	Human	Binding	pKi	=	6.6	6.6	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4095	None	79	Human	Binding	pKi	=	6.6	6.6	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4095	None	79	Human	Binding	pKi	=	6.6	6.6	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	6.6	6.6	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4095	None	79	Human	Binding	pKi	=	6.6	6.6	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60138186	120834	None	0	Human	Binding	pKi	=	6.6	6.6	23	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	60138193	120834	None	0	Human	Binding	pKi	=	6.6	6.6	23	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323288	120834	None	0	Human	Binding	pKi	=	6.6	6.6	23	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558240	120834	None	0	Human	Binding	pKi	=	6.6	6.6	23	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	11504244	106517	None	0	Human	Binding	pKi	=	6.6	6.6	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	60138185	106517	None	0	Human	Binding	pKi	=	6.6	6.6	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3121474	106517	None	0	Human	Binding	pKi	=	6.6	6.6	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3140249	106517	None	0	Human	Binding	pKi	=	6.6	6.6	199	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	44448646	11906	None	0	Human	Binding	pKi	=	6.6	6.6	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182612	11906	None	0	Human	Binding	pKi	=	6.6	6.6	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
	CHEMBL254586	11906	None	0	Human	Binding	pKi	=	6.6	6.6	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
	10035281	100980	None	0	Human	Binding	pKi	=	5.6	5.6	-1	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1016/j.bmc.2007.12.036
	CHEMBL294273	100980	None	0	Human	Binding	pKi	=	5.6	5.6	-1	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1016/j.bmc.2007.12.036
	46227483	14123	None	0	Human	Binding	pKi	=	4.6	4.6	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL1198039	14123	None	0	Human	Binding	pKi	=	4.6	4.6	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL593685	14123	None	0	Human	Binding	pKi	=	4.6	4.6	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	9868297	94112	None	0	Rat	Binding	pKi	=	6.6	6.6	-13	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL249205	94112	None	0	Rat	Binding	pKi	=	6.6	6.6	-13	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	1016	3745	None	78	Human	Binding	pKi	=	5.6	5.6	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3745	None	78	Human	Binding	pKi	=	5.6	5.6	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3745	None	78	Human	Binding	pKi	=	5.6	5.6	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3745	None	78	Human	Binding	pKi	=	5.6	5.6	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3745	None	78	Human	Binding	pKi	=	5.6	5.6	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3745	None	78	Human	Binding	pKi	=	5.6	5.6	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	73347826	92540	None	0	Human	Binding	pKi	=	5.6	5.6	-2	7	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	266	4	1	2	2.4	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)nc1	10.1016/j.bmc.2013.07.045
	CHEMBL2432049	92540	None	0	Human	Binding	pKi	=	5.6	5.6	-2	7	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	266	4	1	2	2.4	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)nc1	10.1016/j.bmc.2013.07.045
	3191	102856	None	97	Human	Binding	pKi	=	6.6	6.6	-8	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	CHEMBL305660	102856	None	97	Human	Binding	pKi	=	6.6	6.6	-8	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	DB11742	102856	None	97	Human	Binding	pKi	=	6.6	6.6	-8	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	44308861	203526	None	0	Human	Binding	pKi	=	7.6	7.6	-16	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	316	4	2	3	2.3	NCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL66400	203526	None	0	Human	Binding	pKi	=	7.6	7.6	-16	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	316	4	2	3	2.3	NCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	44404147	169088	None	12	Rat	Binding	pKi	=	7.6	7.6	-19	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1ccccc1	10.1021/jm050099q
	CHEMBL439867	169088	None	12	Rat	Binding	pKi	=	7.6	7.6	-19	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1ccccc1	10.1021/jm050099q
	CHEMBL5282659	194165	None	0	Human	Binding	pKi	=	7.6	7.6	-14	3	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	465	9	2	4	5.8	NCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	11968014	12756	None	5	Human	Binding	pKi	=	7.5	7.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	119680147	12756	None	5	Human	Binding	pKi	=	7.5	7.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	CHEMBL1187846	12756	None	5	Human	Binding	pKi	=	7.5	7.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	DB00747	12756	None	5	Human	Binding	pKi	=	7.5	7.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	24936155	94620	None	0	Human	Binding	pKi	=	6.6	6.6	-46	7	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	508	4	2	3	5.1	CC(=O)N1C2C=C(CN3C4CCC3CC(NC(=O)Nc3cc(F)cc(C(F)(F)F)c3)C4)CC1CCC2	10.1016/j.bmcl.2007.10.109
	CHEMBL252258	94620	None	0	Human	Binding	pKi	=	6.6	6.6	-46	7	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	508	4	2	3	5.1	CC(=O)N1C2C=C(CN3C4CCC3CC(NC(=O)Nc3cc(F)cc(C(F)(F)F)c3)C4)CC1CCC2	10.1016/j.bmcl.2007.10.109
	44309151	203581	None	0	Human	Binding	pKi	=	5.6	5.6	-60	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.3	NCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL66820	203581	None	0	Human	Binding	pKi	=	5.6	5.6	-60	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.3	NCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	10103909	203302	None	3	Human	Binding	pKi	=	5.6	5.6	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2cccnc2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL64779	203302	None	3	Human	Binding	pKi	=	5.6	5.6	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2cccnc2)C2CCN1CC2	10.1021/jm00003a011
	275176	89811	None	1	Human	Binding	pKi	=	6.6	6.6	-1	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.4	CCN(CC)CCOC(=O)C(O)(c1ccccc1)c1c(C)cccc1C	10.1016/j.bmc.2013.01.072
	CHEMBL2377388	89811	None	1	Human	Binding	pKi	=	6.6	6.6	-1	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.4	CCN(CC)CCOC(=O)C(O)(c1ccccc1)c1c(C)cccc1C	10.1016/j.bmc.2013.01.072
	3055	1432	None	44	Human	Binding	pKi	=	5.6	5.6	-2	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
	313	1432	None	44	Human	Binding	pKi	=	5.6	5.6	-2	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
	7163	1432	None	44	Human	Binding	pKi	=	5.6	5.6	-2	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
	CHEMBL936	1432	None	44	Human	Binding	pKi	=	5.6	5.6	-2	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
	DB01231	1432	None	44	Human	Binding	pKi	=	5.6	5.6	-2	9	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
	67407161	92282	None	0	Human	Binding	pKi	=	4.6	4.6	-1819	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426688	92282	None	0	Human	Binding	pKi	=	4.6	4.6	-1819	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	57326237	77181	None	0	Human	Binding	pKi	=	4.6	4.6	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042407	77181	None	0	Human	Binding	pKi	=	4.6	4.6	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2078985	77181	None	0	Human	Binding	pKi	=	4.6	4.6	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	44384326	59874	None	0	Human	Binding	pKi	=	6.6	6.6	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC1	10.1016/s0960-894x(99)00101-8
	CHEMBL172969	59874	None	0	Human	Binding	pKi	=	6.6	6.6	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC1	10.1016/s0960-894x(99)00101-8
	109013312	180132	None	1	Human	Binding	pKi	=	6.5	6.5	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4748774	180132	None	1	Human	Binding	pKi	=	6.5	6.5	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	11530307	78340	None	0	Human	Binding	pKi	=	4.5	4.5	1	2	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2093082	78340	None	0	Human	Binding	pKi	=	4.5	4.5	1	2	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2109993	78340	None	0	Human	Binding	pKi	=	4.5	4.5	1	2	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	7141654	175787	None	8	Human	Binding	pKi	=	4.5	4.5	-	1	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@@H]2CCCN2)o1	10.1021/jm800145d
	CHEMBL458416	175787	None	8	Human	Binding	pKi	=	4.5	4.5	-	1	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@@H]2CCCN2)o1	10.1021/jm800145d
	180	401	None	56	Human	Binding	pKi	=	7.5	7.5	-27	40	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	200	401	None	56	Human	Binding	pKi	=	7.5	7.5	-27	40	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	2160	401	None	56	Human	Binding	pKi	=	7.5	7.5	-27	40	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	CHEMBL629	401	None	56	Human	Binding	pKi	=	7.5	7.5	-27	40	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	DB00321	401	None	56	Human	Binding	pKi	=	7.5	7.5	-27	40	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	44627739	198370	None	0	Human	Binding	pKi	=	7.5	7.5	1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	333	4	1	3	4.3	CN1CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL576663	198370	None	0	Human	Binding	pKi	=	7.5	7.5	1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	333	4	1	3	4.3	CN1CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	44308818	102079	None	0	Human	Binding	pKi	=	5.5	5.5	-30	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1cccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)c1	10.1016/s0960-894x(03)00350-0
	CHEMBL302145	102079	None	0	Human	Binding	pKi	=	5.5	5.5	-30	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1cccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)c1	10.1016/s0960-894x(03)00350-0
	14964495	12611	None	1	Rat	Binding	pKi	=	5.5	5.5	4	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118700	12611	None	1	Rat	Binding	pKi	=	5.5	5.5	4	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	199230	163133	None	21	Rat	Binding	pKi	=	5.5	5.5	37	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	CHEMBL41779	163133	None	21	Rat	Binding	pKi	=	5.5	5.5	37	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	137630127	161047	None	0	Human	Binding	pKi	=	4.5	4.5	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4084607	161047	None	0	Human	Binding	pKi	=	4.5	4.5	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116537	161047	None	0	Human	Binding	pKi	=	4.5	4.5	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	16125443	84647	None	0	Human	Binding	pKi	=	5.5	5.5	-3	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	335	3	1	2	3.1	CN1CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061159a
	CHEMBL222402	84647	None	0	Human	Binding	pKi	=	5.5	5.5	-3	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	335	3	1	2	3.1	CN1CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061159a
	44274400	98936	None	0	Human	Binding	pKi	=	4.5	4.5	-1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL279520	98936	None	0	Human	Binding	pKi	=	4.5	4.5	-1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	3675988	176833	None	66	Human	Binding	pKi	=	4.5	4.5	-2	4	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc(C2CCCN2)c1	10.1021/jm800145d
	CHEMBL461087	176833	None	66	Human	Binding	pKi	=	4.5	4.5	-2	4	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc(C2CCCN2)c1	10.1021/jm800145d
	16125437	84346	None	0	Human	Binding	pKi	=	5.5	5.5	-19	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	4.9	O=C1NC(Cc2ccccc2)(Cc2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL221713	84346	None	0	Human	Binding	pKi	=	5.5	5.5	-19	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	4.9	O=C1NC(Cc2ccccc2)(Cc2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	16125568	97328	None	0	Human	Binding	pKi	=	6.5	6.5	-17	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccc(Cl)cc2)CC1	10.1021/jm061159a
	CHEMBL269280	97328	None	0	Human	Binding	pKi	=	6.5	6.5	-17	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccc(Cl)cc2)CC1	10.1021/jm061159a
	7333	99355	None	79	Rat	Binding	pKi	=	5.5	5.5	-3	2	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	239	2	3	1	3.8	Cc1ccccc1NC(=N)Nc1ccccc1C	10.1021/jm00039a008
	CHEMBL282433	99355	None	79	Rat	Binding	pKi	=	5.5	5.5	-3	2	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	239	2	3	1	3.8	Cc1ccccc1NC(=N)Nc1ccccc1C	10.1021/jm00039a008
	1530	2180	None	50	Human	Binding	pKi	=	6.5	6.5	-43	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	3827	2180	None	50	Human	Binding	pKi	=	6.5	6.5	-43	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	7206	2180	None	50	Human	Binding	pKi	=	6.5	6.5	-43	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	CHEMBL534	2180	None	50	Human	Binding	pKi	=	6.5	6.5	-43	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	DB00920	2180	None	50	Human	Binding	pKi	=	6.5	6.5	-43	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	10410916	94068	None	0	Rat	Binding	pKi	=	6.5	6.5	-9	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	438	7	2	3	4.0	O=C(N[C@H]1[C@@H]2CN(CCc3ccc(Cl)cc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL249007	94068	None	0	Rat	Binding	pKi	=	6.5	6.5	-9	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	438	7	2	3	4.0	O=C(N[C@H]1[C@@H]2CN(CCc3ccc(Cl)cc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	44378598	58135	None	0	Human	Binding	pKi	=	8.5	8.5	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1c(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)ccc2c1OCO2	10.1016/s0960-894x(02)00024-0
	CHEMBL167838	58135	None	0	Human	Binding	pKi	=	8.5	8.5	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1c(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)ccc2c1OCO2	10.1016/s0960-894x(02)00024-0
	156014820	178303	None	0	Human	Binding	pKi	=	8.5	8.5	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4646116	178303	None	0	Human	Binding	pKi	=	8.5	8.5	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650998	178303	None	0	Human	Binding	pKi	=	8.5	8.5	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	11968014	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	119680147	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	CHEMBL1187846	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	DB00747	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	10225340	204332	None	0	Human	Binding	pKi	=	8.5	8.5	2	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	441	6	0	5	4.8	COc1ccc(S(=O)(=O)c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL71531	204332	None	0	Human	Binding	pKi	=	8.5	8.5	2	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	441	6	0	5	4.8	COc1ccc(S(=O)(=O)c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	174174	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	25034182	172582	None	0	Human	Binding	pKi	=	8.5	8.5	-2	3	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL448870	172582	None	0	Human	Binding	pKi	=	8.5	8.5	-2	3	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL540359	172582	None	0	Human	Binding	pKi	=	8.5	8.5	-2	3	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	25010559	96767	None	0	Human	Binding	pKi	=	8.5	8.5	-10	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL264676	96767	None	0	Human	Binding	pKi	=	8.5	8.5	-10	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	9936450	35153	None	0	Human	Binding	pKi	=	8.5	8.5	-4	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	518	14	0	10	5.0	CN1CCC=C(c2nsnc2OCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm501173q
	CHEMBL143469	35153	None	0	Human	Binding	pKi	=	8.5	8.5	-4	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	518	14	0	10	5.0	CN1CCC=C(c2nsnc2OCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm501173q
	44406597	72907	None	0	Human	Binding	pKi	=	8.5	8.5	-12	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	339	3	1	3	3.2	COC1(C#CC(O)(c2ccccc2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200432	72907	None	0	Human	Binding	pKi	=	8.5	8.5	-12	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	339	3	1	3	3.2	COC1(C#CC(O)(c2ccccc2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406686	140909	None	0	Human	Binding	pKi	=	8.5	8.5	-3	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL382213	140909	None	0	Human	Binding	pKi	=	8.5	8.5	-3	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44382699	59138	None	0	Human	Binding	pKi	=	8.5	8.5	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	6	0	8	4.1	CC(C)OC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL169876	59138	None	0	Human	Binding	pKi	=	8.5	8.5	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	6	0	8	4.1	CC(C)OC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	129989	451	None	51	Rat	Binding	pKi	=	8.5	8.5	1	9	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	8584	451	None	51	Rat	Binding	pKi	=	8.5	8.5	1	9	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	CHEMBL43383	451	None	51	Rat	Binding	pKi	=	8.5	8.5	1	9	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	44292486	181509	None	0	Rat	Binding	pKi	=	8.5	8.5	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	CHEMBL47650	181509	None	0	Rat	Binding	pKi	=	8.5	8.5	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	11968014	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	119680147	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	CHEMBL1187846	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	DB00747	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	11968014	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	119680147	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	CHEMBL1187846	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	DB00747	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	118710670	120831	None	0	Human	Binding	pKi	=	8.5	8.5	-1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323284	120831	None	0	Human	Binding	pKi	=	8.5	8.5	-1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558233	120831	None	0	Human	Binding	pKi	=	8.5	8.5	-1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	16115801	12293	None	0	Human	Binding	pKi	=	8.5	8.5	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL1184882	12293	None	0	Human	Binding	pKi	=	8.5	8.5	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL375851	12293	None	0	Human	Binding	pKi	=	8.5	8.5	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	9883040	100535	None	0	Human	Binding	pKi	=	8.5	8.5	-8	4	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL291339	100535	None	0	Human	Binding	pKi	=	8.5	8.5	-8	4	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL542622	100535	None	0	Human	Binding	pKi	=	8.5	8.5	-8	4	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	156011965	177290	None	0	Human	Binding	pKi	=	8.5	8.5	-51	3	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	380	4	2	3	4.8	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OCC1CCNCC1	10.1021/acs.jmedchem.2c01376
	CHEMBL4636528	177290	None	0	Human	Binding	pKi	=	8.5	8.5	-51	3	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	380	4	2	3	4.8	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OCC1CCNCC1	10.1021/acs.jmedchem.2c01376
	70685504	74452	None	0	Human	Binding	pKi	=	8.5	8.5	1	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
	CHEMBL2021478	74452	None	0	Human	Binding	pKi	=	8.5	8.5	1	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
	CHEMBL2027846	74452	None	0	Human	Binding	pKi	=	8.5	8.5	1	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
	11968014	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	119680147	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	CHEMBL1187846	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	DB00747	12756	None	5	Human	Binding	pKi	=	8.5	8.5	-4	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	164625419	188588	None	0	Human	Binding	pKi	=	8.5	8.5	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4862087	188588	None	0	Human	Binding	pKi	=	8.5	8.5	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028881	188588	None	0	Human	Binding	pKi	=	8.5	8.5	5	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	71461681	79538	None	0	Human	Binding	pKi	=	8.5	8.5	5	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2114067	79538	None	0	Human	Binding	pKi	=	8.5	8.5	5	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	59291461	112773	None	0	Rat	Binding	pKi	=	8.4	8.4	-17	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298334	112773	None	0	Rat	Binding	pKi	=	8.4	8.4	-17	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305613	112773	None	0	Rat	Binding	pKi	=	8.4	8.4	-17	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	23983764	10331	None	0	Human	Binding	pKi	=	8.4	8.4	1	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	3	0	5	1.3	Cc1nccn1CC#CCOc1ccon1	10.1016/j.bmc.2007.12.036
	CHEMBL1162116	10331	None	0	Human	Binding	pKi	=	8.4	8.4	1	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	3	0	5	1.3	Cc1nccn1CC#CCOc1ccon1	10.1016/j.bmc.2007.12.036
	154417	93258	None	60	Human	Binding	pKi	=	8.4	8.4	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL1331216	93258	None	60	Human	Binding	pKi	=	8.4	8.4	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL2449003	93258	None	60	Human	Binding	pKi	=	8.4	8.4	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	DB00424	93258	None	60	Human	Binding	pKi	=	8.4	8.4	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	1201549	596	None	24	Human	Binding	pKi	=	8.4	8.4	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	333	596	None	24	Human	Binding	pKi	=	8.4	8.4	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	7601	596	None	24	Human	Binding	pKi	=	8.4	8.4	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL1201203	596	None	24	Human	Binding	pKi	=	8.4	8.4	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL438151	596	None	24	Human	Binding	pKi	=	8.4	8.4	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	DB00245	596	None	24	Human	Binding	pKi	=	8.4	8.4	-5	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	9892600	58494	None	0	Rat	Binding	pKi	=	8.4	8.4	-1	2	Inhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heartInhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	511	12	2	6	5.0	Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCN)CC1)c1ccccc1NC2=O	10.1016/S0960-894X(00)80542-9
	CHEMBL168329	58494	None	0	Rat	Binding	pKi	=	8.4	8.4	-1	2	Inhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heartInhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	511	12	2	6	5.0	Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCN)CC1)c1ccccc1NC2=O	10.1016/S0960-894X(00)80542-9
	14939897	96547	None	0	Rat	Binding	pKi	=	8.4	8.4	-2	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201994	96547	None	0	Rat	Binding	pKi	=	8.4	8.4	-2	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL262913	96547	None	0	Rat	Binding	pKi	=	8.4	8.4	-2	4	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44311761	102848	None	0	Human	Binding	pKi	=	8.4	8.4	15	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL305607	102848	None	0	Human	Binding	pKi	=	8.4	8.4	15	2	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	9889312	78428	None	0	Human	Binding	pKi	=	8.4	8.4	2	5	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL2111540	78428	None	0	Human	Binding	pKi	=	8.4	8.4	2	5	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	9798900	63134	None	1	Rat	Binding	pKi	=	8.4	8.4	-26	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL1779047	63134	None	1	Rat	Binding	pKi	=	8.4	8.4	-26	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL1789446	63134	None	1	Rat	Binding	pKi	=	8.4	8.4	-26	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	44311761	102848	None	0	Human	Binding	pKi	=	8.4	8.4	15	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL305607	102848	None	0	Human	Binding	pKi	=	8.4	8.4	15	2	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	1734	116	None	10	Rat	Binding	pKi	=	8.4	8.4	-12	13	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	307	116	None	10	Rat	Binding	pKi	=	8.4	8.4	-12	13	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	CHEMBL168067	116	None	10	Rat	Binding	pKi	=	8.4	8.4	-12	13	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	69058946	106473	None	0	Human	Binding	pKi	=	8.4	8.4	-2	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084658	106473	None	0	Human	Binding	pKi	=	8.4	8.4	-2	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140110	106473	None	0	Human	Binding	pKi	=	8.4	8.4	-2	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44233192	106480	None	0	Human	Binding	pKi	=	8.4	8.4	-3	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084643	106480	None	0	Human	Binding	pKi	=	8.4	8.4	-3	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140141	106480	None	0	Human	Binding	pKi	=	8.4	8.4	-3	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	70687661	74451	None	0	Human	Binding	pKi	=	8.4	8.4	3	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2021476	74451	None	0	Human	Binding	pKi	=	8.4	8.4	3	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2027845	74451	None	0	Human	Binding	pKi	=	8.4	8.4	3	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	1734	116	None	10	Rat	Binding	pKi	=	8.4	8.4	-12	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
	307	116	None	10	Rat	Binding	pKi	=	8.4	8.4	-12	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
	CHEMBL168067	116	None	10	Rat	Binding	pKi	=	8.4	8.4	-12	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
	11039424	78914	None	1	Human	Binding	pKi	=	7.5	7.5	-97	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	622	14	3	4	5.4	O=C(CCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL2112955	78914	None	1	Human	Binding	pKi	=	7.5	7.5	-97	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	622	14	3	4	5.4	O=C(CCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	155529196	171408	None	0	Human	Binding	pKi	=	7.5	7.5	-1	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	4	0	3	4.4	Cc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
	CHEMBL4462631	171408	None	0	Human	Binding	pKi	=	7.5	7.5	-1	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	4	0	3	4.4	Cc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
	155554149	175445	None	0	Human	Binding	pKi	=	7.5	7.5	-1	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	4	0	5	3.7	O=C(OCc1ccc2c(c1)OCO2)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	CHEMBL4576768	175445	None	0	Human	Binding	pKi	=	7.5	7.5	-1	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	4	0	5	3.7	O=C(OCc1ccc2c(c1)OCO2)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	10500741	38544	None	0	Human	Binding	pKi	=	7.5	7.5	-12	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	392	6	2	3	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL146464	38544	None	0	Human	Binding	pKi	=	7.5	7.5	-12	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	392	6	2	3	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	10104	3564	None	12	Human	Binding	pKi	=	7.5	7.5	2	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
	6604866	3564	None	12	Human	Binding	pKi	=	7.5	7.5	2	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
	CHEMBL1493369	3564	None	12	Human	Binding	pKi	=	7.5	7.5	2	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
	132712	171796	None	19	Human	Binding	pKi	=	7.5	7.5	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting method	ChEMBL	567	10	1	5	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccc(Cl)cc3C(=O)Nc3cccnc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4468100	171796	None	19	Human	Binding	pKi	=	7.5	7.5	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting method	ChEMBL	567	10	1	5	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccc(Cl)cc3C(=O)Nc3cccnc32)CC1	10.1021/acs.jmedchem.8b01967
	73353378	89800	None	0	Human	Binding	pKi	=	7.5	7.5	-2	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	331	4	1	4	2.4	CN1CCC(OC(=O)C(CO)c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2013.01.072
	CHEMBL2377268	89800	None	0	Human	Binding	pKi	=	7.5	7.5	-2	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	331	4	1	4	2.4	CN1CCC(OC(=O)C(CO)c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2013.01.072
	44309231	169496	None	0	Human	Binding	pKi	=	6.5	6.5	-301	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	2	3	3.7	CCC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL443267	169496	None	0	Human	Binding	pKi	=	6.5	6.5	-301	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	2	3	3.7	CCC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	44308913	203965	None	0	Human	Binding	pKi	=	6.5	6.5	-19	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	381	4	2	4	0.9	NCC(=O)N1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL69402	203965	None	0	Human	Binding	pKi	=	6.5	6.5	-19	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	381	4	2	4	0.9	NCC(=O)N1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	155511167	169556	None	0	Human	Binding	pKi	=	6.5	6.5	-5	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	432	6	0	3	5.7	O=C(OCCCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	CHEMBL4435641	169556	None	0	Human	Binding	pKi	=	6.5	6.5	-5	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	432	6	0	3	5.7	O=C(OCCCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	10105296	205920	None	0	Human	Binding	pKi	=	6.5	6.5	-2	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
	CHEMBL84113	205920	None	0	Human	Binding	pKi	=	6.5	6.5	-2	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
	10244370	121523	None	0	Human	Binding	pKi	=	5.5	5.5	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	260	1	1	4	2.2	OC1(c2nc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL358505	121523	None	0	Human	Binding	pKi	=	5.5	5.5	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	260	1	1	4	2.2	OC1(c2nc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
	16086003	80429	None	0	Human	Binding	pKi	=	5.5	5.5	-724	4	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	CHEMBL214642	80429	None	0	Human	Binding	pKi	=	5.5	5.5	-724	4	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	14964497	14289	None	0	Rat	Binding	pKi	=	4.5	4.5	-	1	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119985	14289	None	0	Rat	Binding	pKi	=	4.5	4.5	-	1	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	15749863	154609	None	5	Human	Binding	pKi	=	4.5	4.5	-3	2	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	197	0	0	3	1.2	CC1(C)OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	CHEMBL39922	154609	None	5	Human	Binding	pKi	=	4.5	4.5	-3	2	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	197	0	0	3	1.2	CC1(C)OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	156009611	178255	None	0	Human	Binding	pKi	=	5.5	5.5	2	2	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4634605	178255	None	0	Human	Binding	pKi	=	5.5	5.5	2	2	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650698	178255	None	0	Human	Binding	pKi	=	5.5	5.5	2	2	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	156015730	178314	None	0	Human	Binding	pKi	=	5.5	5.5	2	2	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4644389	178314	None	0	Human	Binding	pKi	=	5.5	5.5	2	2	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651081	178314	None	0	Human	Binding	pKi	=	5.5	5.5	2	2	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	16125508	84330	None	0	Human	Binding	pKi	=	6.5	6.5	3	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	1	3	4.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccnc2)CC1	10.1021/jm061159a
	CHEMBL221660	84330	None	0	Human	Binding	pKi	=	6.5	6.5	3	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	1	3	4.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccnc2)CC1	10.1021/jm061159a
	16125680	136635	None	0	Human	Binding	pKi	=	6.5	6.5	-70	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	429	5	1	2	4.8	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	CHEMBL373994	136635	None	0	Human	Binding	pKi	=	6.5	6.5	-70	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	429	5	1	2	4.8	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	44593621	193295	None	0	Human	Binding	pKi	=	6.5	6.5	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL524061	193295	None	0	Human	Binding	pKi	=	6.5	6.5	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	611101	203877	None	3	Rat	Binding	pKi	=	5.5	5.5	-2	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	380	4	2	6	0.9	NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL68771	203877	None	3	Rat	Binding	pKi	=	5.5	5.5	-2	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	380	4	2	6	0.9	NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	10315426	101046	None	0	Human	Binding	pKi	=	6.5	6.5	2	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL294663	101046	None	0	Human	Binding	pKi	=	6.5	6.5	2	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	118710666	120827	None	0	Human	Binding	pKi	=	6.5	6.5	-4	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323282	120827	None	0	Human	Binding	pKi	=	6.5	6.5	-4	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558210	120827	None	0	Human	Binding	pKi	=	6.5	6.5	-4	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	155559291	176657	None	0	Human	Binding	pKi	=	6.5	6.5	3	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4563530	176657	None	0	Human	Binding	pKi	=	6.5	6.5	3	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4598099	176657	None	0	Human	Binding	pKi	=	6.5	6.5	3	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	24894514	172732	None	3	Human	Binding	pKi	=	4.5	4.5	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@H]1c1ccco1	10.1021/jm800145d
	CHEMBL450729	172732	None	3	Human	Binding	pKi	=	4.5	4.5	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@H]1c1ccco1	10.1021/jm800145d
	463493	203634	None	1	Human	Binding	pKi	=	7.5	7.5	-	1	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	575	6	0	7	4.3	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL67172	203634	None	1	Human	Binding	pKi	=	7.5	7.5	-	1	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	575	6	0	7	4.3	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	44400323	68667	None	0	Rat	Binding	pKi	=	7.5	7.5	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	361	5	1	4	2.4	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
	CHEMBL192065	68667	None	0	Rat	Binding	pKi	=	7.5	7.5	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	361	5	1	4	2.4	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
	9859365	8495	None	2	Human	Binding	pKi	=	7.5	7.5	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2cc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL109405	8495	None	2	Human	Binding	pKi	=	7.5	7.5	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2cc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
	16125589	84697	None	0	Human	Binding	pKi	=	7.5	7.5	-16	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	6	1	2	4.1	C[N+]1(CC(=O)c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222636	84697	None	0	Human	Binding	pKi	=	7.5	7.5	-16	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	6	1	2	4.1	C[N+]1(CC(=O)c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	167962	4067	None	4	Human	Binding	pKi	=	7.5	7.5	-	1	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4067	None	4	Human	Binding	pKi	=	7.5	7.5	-	1	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4067	None	4	Human	Binding	pKi	=	7.5	7.5	-	1	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	44449463	96103	None	0	Human	Binding	pKi	=	7.5	7.5	-12	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL260228	96103	None	0	Human	Binding	pKi	=	7.5	7.5	-12	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	44627744	14038	None	0	Human	Binding	pKi	=	7.5	7.5	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL1197389	14038	None	0	Human	Binding	pKi	=	7.5	7.5	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL569729	14038	None	0	Human	Binding	pKi	=	7.5	7.5	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	167962	4067	None	4	Human	Binding	pKi	=	7.5	7.5	-	1	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4067	None	4	Human	Binding	pKi	=	7.5	7.5	-	1	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4067	None	4	Human	Binding	pKi	=	7.5	7.5	-	1	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	6472	202745	None	35	Rat	Binding	pKi	=	7.5	7.5	-4	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00114a005
	CHEMBL61946	202745	None	35	Rat	Binding	pKi	=	7.5	7.5	-4	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00114a005
	44318736	107019	None	0	Human	Binding	pKi	=	6.5	6.5	-2	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
	CHEMBL315428	107019	None	0	Human	Binding	pKi	=	6.5	6.5	-2	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
	16086066	139233	None	0	Human	Binding	pKi	=	6.5	6.5	-794	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	CHEMBL378872	139233	None	0	Human	Binding	pKi	=	6.5	6.5	-794	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	10503358	38684	None	0	Human	Binding	pKi	=	6.5	6.5	-354	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	442	6	2	3	4.4	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	CHEMBL146567	38684	None	0	Human	Binding	pKi	=	6.5	6.5	-354	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	442	6	2	3	4.4	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	10647703	120966	None	0	Human	Binding	pKi	=	6.5	6.5	-123	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	461	6	3	4	3.8	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1F	10.1021/jm0003135
	CHEMBL356181	120966	None	0	Human	Binding	pKi	=	6.5	6.5	-123	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	461	6	3	4	3.8	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1F	10.1021/jm0003135
	44318851	104724	None	0	Human	Binding	pKi	=	5.5	5.5	-3	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	CHEMBL310558	104724	None	0	Human	Binding	pKi	=	5.5	5.5	-3	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	10984804	98474	None	0	Human	Binding	pKi	=	5.5	5.5	-30	2	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	592	9	2	4	4.5	O=C(NC[C@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	CHEMBL275914	98474	None	0	Human	Binding	pKi	=	5.5	5.5	-30	2	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	592	9	2	4	4.5	O=C(NC[C@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	10835518	40325	None	0	Human	Binding	pKi	=	5.5	5.5	-257	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	3	4.6	O=C(NC1CCN(CC2CCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL148129	40325	None	0	Human	Binding	pKi	=	5.5	5.5	-257	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	3	4.6	O=C(NC1CCN(CC2CCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	44383554	120788	None	0	Human	Binding	pKi	=	6.5	6.5	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C1	10.1016/s0960-894x(99)00101-8
	CHEMBL355475	120788	None	0	Human	Binding	pKi	=	6.5	6.5	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C1	10.1016/s0960-894x(99)00101-8
	44406476	140522	None	0	Human	Binding	pKi	=	6.5	6.5	-15	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	326	3	1	4	2.2	COC1(C#CC(O)(c2ccccn2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381020	140522	None	0	Human	Binding	pKi	=	6.5	6.5	-15	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	326	3	1	4	2.2	COC1(C#CC(O)(c2ccccn2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	9913892	205835	None	0	Human	Binding	pKi	=	6.5	6.5	-100	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83459	205835	None	0	Human	Binding	pKi	=	6.5	6.5	-100	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319006	206170	None	0	Human	Binding	pKi	=	6.5	6.5	-12	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	4.9	O=C(Cc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL86309	206170	None	0	Human	Binding	pKi	=	6.5	6.5	-12	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	4.9	O=C(Cc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	10044685	206331	None	6	Human	Binding	pKi	=	6.5	6.5	-12	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	370	5	0	2	5.0	O=C(c1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL87302	206331	None	6	Human	Binding	pKi	=	6.5	6.5	-12	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	370	5	0	2	5.0	O=C(c1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	10109893	82163	None	0	Human	Binding	pKi	=	6.5	6.5	-1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL216983	82163	None	0	Human	Binding	pKi	=	6.5	6.5	-1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL544840	82163	None	0	Human	Binding	pKi	=	6.5	6.5	-1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	44406342	72168	None	0	Human	Binding	pKi	=	5.5	5.5	-5	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	5	1	3	3.3	COC1(C#CC(O)(Cc2ccccc2)Cc2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL197973	72168	None	0	Human	Binding	pKi	=	5.5	5.5	-5	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	5	1	3	3.3	COC1(C#CC(O)(Cc2ccccc2)Cc2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	11536903	2395	None	68	Human	Binding	pKi	=	5.5	5.5	-6	2	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	3262	2395	None	68	Human	Binding	pKi	=	5.5	5.5	-6	2	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	CHEMBL3770346	2395	None	68	Human	Binding	pKi	=	5.5	5.5	-6	2	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	10164480	43343	None	0	Human	Binding	pKi	=	7.5	7.5	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	509	5	1	5	4.9	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
	CHEMBL150707	43343	None	0	Human	Binding	pKi	=	7.5	7.5	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	509	5	1	5	4.9	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
	6472	202745	None	35	Rat	Binding	pKi	=	7.5	7.5	-4	2	Binding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligand	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
	CHEMBL61946	202745	None	35	Rat	Binding	pKi	=	7.5	7.5	-4	2	Binding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligand	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
	9985181	120356	None	0	Human	Binding	pKi	=	7.5	7.5	1	3	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	556	9	1	4	6.1	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
	CHEMBL353140	120356	None	0	Human	Binding	pKi	=	7.5	7.5	1	3	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	556	9	1	4	6.1	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
	44383653	120849	None	0	Human	Binding	pKi	=	7.5	7.5	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL355854	120849	None	0	Human	Binding	pKi	=	7.5	7.5	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(99)00101-8
	10969390	59675	None	0	Human	Binding	pKi	=	7.5	7.5	-4	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	324	7	0	2	4.5	CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL172233	59675	None	0	Human	Binding	pKi	=	7.5	7.5	-4	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	324	7	0	2	4.5	CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	9843967	155456	None	1	Human	Binding	pKi	=	6.5	6.5	1	2	Binding affinity of compound to m2 muscarinic receptorBinding affinity of compound to m2 muscarinic receptor	ChEMBL	400	7	1	5	3.4	Nc1cccc(-c2ccc(CCN3CCN(CC(=O)c4ccccc4)CC3)cc2)n1	10.1016/s0960-894x(99)00432-1
	CHEMBL40391	155456	None	1	Human	Binding	pKi	=	6.5	6.5	1	2	Binding affinity of compound to m2 muscarinic receptorBinding affinity of compound to m2 muscarinic receptor	ChEMBL	400	7	1	5	3.4	Nc1cccc(-c2ccc(CCN3CCN(CC(=O)c4ccccc4)CC3)cc2)n1	10.1016/s0960-894x(99)00432-1
	10092649	193071	None	56	Human	Binding	pKi	=	6.5	6.5	-28	9	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1021/jm100697g
	CHEMBL522460	193071	None	56	Human	Binding	pKi	=	6.5	6.5	-28	9	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1021/jm100697g
	11794901	119581	None	0	Human	Binding	pKi	=	6.5	6.5	-22	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccccn2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL346194	119581	None	0	Human	Binding	pKi	=	6.5	6.5	-22	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccccn2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	611066	157507	None	1	Rat	Binding	pKi	=	5.5	5.5	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	381	4	2	6	0.9	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCO)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL407975	157507	None	1	Rat	Binding	pKi	=	5.5	5.5	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	381	4	2	6	0.9	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCO)CC2)c2ccccc21	10.1021/jm00111a032
	10043954	82276	None	0	Human	Binding	pKi	=	6.5	6.5	3	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21716	82276	None	0	Human	Binding	pKi	=	6.5	6.5	3	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	302	2975	None	25	Human	Binding	pKi	=	6.5	6.5	-34	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
	4630	2975	None	25	Human	Binding	pKi	=	6.5	6.5	-34	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
	CHEMBL7634	2975	None	25	Human	Binding	pKi	=	6.5	6.5	-34	8	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
	3652	4095	None	79	Human	Binding	pKi	=	6.5	6.5	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4095	None	79	Human	Binding	pKi	=	6.5	6.5	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4095	None	79	Human	Binding	pKi	=	6.5	6.5	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	6.5	6.5	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4095	None	79	Human	Binding	pKi	=	6.5	6.5	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	164624458	188581	None	0	Human	Binding	pKi	=	6.5	6.5	11	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4863121	188581	None	0	Human	Binding	pKi	=	6.5	6.5	11	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028823	188581	None	0	Human	Binding	pKi	=	6.5	6.5	11	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164625211	188586	None	0	Human	Binding	pKi	=	6.5	6.5	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4869865	188586	None	0	Human	Binding	pKi	=	6.5	6.5	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028864	188586	None	0	Human	Binding	pKi	=	6.5	6.5	15	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	171578	12302	None	5	Human	Binding	pKi	=	5.5	5.5	-1	5	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
	CHEMBL1184962	12302	None	5	Human	Binding	pKi	=	5.5	5.5	-1	5	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
	CHEMBL380759	12302	None	5	Human	Binding	pKi	=	5.5	5.5	-1	5	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
	162353374	180041	None	0	Human	Binding	pKi	=	5.5	5.5	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4747590	180041	None	0	Human	Binding	pKi	=	5.5	5.5	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	118719925	115777	None	0	Human	Binding	pKi	=	5.5	5.5	-43	8	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	330	7	1	3	2.8	O=C1CCc2ccccc2N1CCCN1CCC(CCCO)CC1	10.1021/jm501173q
	CHEMBL3354072	115777	None	0	Human	Binding	pKi	=	5.5	5.5	-43	8	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	330	7	1	3	2.8	O=C1CCc2ccccc2N1CCCN1CCC(CCCO)CC1	10.1021/jm501173q
	44627856	197487	None	0	Human	Binding	pKi	=	5.5	5.5	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569953	197487	None	0	Human	Binding	pKi	=	5.5	5.5	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	290	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
	4022	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
	5926	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
	CHEMBL40554	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
	CHEMBL74300	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
	7141656	176835	None	7	Human	Binding	pKi	=	5.5	5.5	3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@H]2CCCN2)o1	10.1021/jm800145d
	CHEMBL461089	176835	None	7	Human	Binding	pKi	=	5.5	5.5	3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@H]2CCCN2)o1	10.1021/jm800145d
	290	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
	4022	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
	5926	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
	CHEMBL40554	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
	CHEMBL74300	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
	290	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
	4022	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
	5926	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
	CHEMBL40554	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
	CHEMBL74300	2471	None	6	Human	Binding	pKi	=	5.5	5.5	-6	7	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
	156015484	178289	None	0	Human	Binding	pKi	=	5.5	5.5	-	1	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4645254	178289	None	0	Human	Binding	pKi	=	5.5	5.5	-	1	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650952	178289	None	0	Human	Binding	pKi	=	5.5	5.5	-	1	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	11101362	5123	None	0	Human	Binding	pKi	=	5.5	5.5	-8	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Cl)ccc2C1O3	10.1021/jm011116o
	CHEMBL105674	5123	None	0	Human	Binding	pKi	=	5.5	5.5	-8	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Cl)ccc2C1O3	10.1021/jm011116o
	16125567	84756	None	0	Human	Binding	pKi	=	6.5	6.5	-104	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	CHEMBL223016	84756	None	0	Human	Binding	pKi	=	6.5	6.5	-104	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	16125507	166177	None	0	Human	Binding	pKi	=	6.5	6.5	-1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	7	1	3	4.5	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCOc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL426393	166177	None	0	Human	Binding	pKi	=	6.5	6.5	-1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	7	1	3	4.5	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCOc2ccccc2)CC1	10.1021/jm061159a
	44312464	204654	None	0	Human	Binding	pKi	=	7.5	7.5	2	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	468	5	0	4	5.8	CC(c1ccc(S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL73661	204654	None	0	Human	Binding	pKi	=	7.5	7.5	2	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	468	5	0	4	5.8	CC(c1ccc(S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	11759212	57890	None	0	Human	Binding	pKi	=	7.5	7.5	-40	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL167223	57890	None	0	Human	Binding	pKi	=	7.5	7.5	-40	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
	10316726	12026	None	0	Rat	Binding	pKi	=	7.5	7.5	-35	5	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	12026	None	0	Rat	Binding	pKi	=	7.5	7.5	-35	5	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	12026	None	0	Rat	Binding	pKi	=	7.5	7.5	-35	5	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	155554262	176553	None	0	Human	Binding	pKi	=	7.5	7.5	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582069	176553	None	0	Human	Binding	pKi	=	7.5	7.5	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597244	176553	None	0	Human	Binding	pKi	=	7.5	7.5	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	57326233	77184	None	0	Human	Binding	pKi	=	7.5	7.5	-2	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042406	77184	None	0	Human	Binding	pKi	=	7.5	7.5	-2	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2079010	77184	None	0	Human	Binding	pKi	=	7.5	7.5	-2	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	145960466	161521	None	0	Human	Binding	pKi	=	7.5	7.5	-7	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	CHEMBL4128341	161521	None	0	Human	Binding	pKi	=	7.5	7.5	-7	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	10058649	36123	None	0	Human	Binding	pKi	=	6.5	6.5	1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	201	1	1	2	2.5	Oc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL144434	36123	None	0	Human	Binding	pKi	=	6.5	6.5	1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	201	1	1	2	2.5	Oc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
	10670917	165062	None	0	Human	Binding	pKi	=	6.5	6.5	-102	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	CHEMBL422665	165062	None	0	Human	Binding	pKi	=	6.5	6.5	-102	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	14964495	12611	None	1	Rat	Binding	pKi	=	5.5	5.5	4	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118700	12611	None	1	Rat	Binding	pKi	=	5.5	5.5	4	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	10739662	42274	None	0	Human	Binding	pKi	=	5.5	5.5	-194	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	3	4.2	O=C(NC1CCN(CC2CCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL149769	42274	None	0	Human	Binding	pKi	=	5.5	5.5	-194	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	3	4.2	O=C(NC1CCN(CC2CCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	10066972	98752	None	0	Human	Binding	pKi	=	6.5	6.5	3	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL278074	98752	None	0	Human	Binding	pKi	=	6.5	6.5	3	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	109035013	180473	None	1	Human	Binding	pKi	=	5.5	5.5	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	CHEMBL4752973	180473	None	1	Human	Binding	pKi	=	5.5	5.5	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	162353383	182575	None	0	Human	Binding	pKi	=	5.5	5.5	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	CHEMBL4787944	182575	None	0	Human	Binding	pKi	=	5.5	5.5	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	71449073	78580	None	0	Rat	Binding	pKi	=	5.5	5.5	-8	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	338	2	2	6	0.6	O=C1Nc2cccnc2N(C(=O)CN2CCNCC2)c2ncccc21	10.1021/jm00111a032
	CHEMBL2112217	78580	None	0	Rat	Binding	pKi	=	5.5	5.5	-8	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	338	2	2	6	0.6	O=C1Nc2cccnc2N(C(=O)CN2CCNCC2)c2ncccc21	10.1021/jm00111a032
	631645	164874	None	1	Rat	Binding	pKi	=	5.5	5.5	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	565	9	3	8	2.4	CC(C)(C)OC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL422053	164874	None	1	Rat	Binding	pKi	=	5.5	5.5	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	565	9	3	8	2.4	CC(C)(C)OC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	44443731	94210	None	0	Rat	Binding	pKi	=	6.5	6.5	-36	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	7	2	3	3.4	O=C(N[C@H]1[C@@H]2CN(CCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL249830	94210	None	0	Rat	Binding	pKi	=	6.5	6.5	-36	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	7	2	3	3.4	O=C(N[C@H]1[C@@H]2CN(CCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	24882532	95115	None	0	Rat	Binding	pKi	=	6.5	6.5	-26	5	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255523	95115	None	0	Rat	Binding	pKi	=	6.5	6.5	-26	5	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	10160073	111187	None	0	Human	Binding	pKi	=	6.5	6.5	-338	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL326450	111187	None	0	Human	Binding	pKi	=	6.5	6.5	-338	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	156015465	178322	None	0	Human	Binding	pKi	=	5.5	5.5	-1	4	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4640926	178322	None	0	Human	Binding	pKi	=	5.5	5.5	-1	4	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651115	178322	None	0	Human	Binding	pKi	=	5.5	5.5	-1	4	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	46227485	14121	None	0	Human	Binding	pKi	=	4.5	4.5	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL1198034	14121	None	0	Human	Binding	pKi	=	4.5	4.5	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL593620	14121	None	0	Human	Binding	pKi	=	4.5	4.5	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	10160073	111187	None	0	Human	Binding	pKi	=	6.5	6.5	-338	5	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm301774u
	CHEMBL326450	111187	None	0	Human	Binding	pKi	=	6.5	6.5	-338	5	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm301774u
	10381417	68666	None	0	Rat	Binding	pKi	=	7.5	7.5	1	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	CHEMBL192061	68666	None	0	Rat	Binding	pKi	=	7.5	7.5	1	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	44312460	204619	None	0	Human	Binding	pKi	=	7.5	7.5	2	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	344	4	0	4	2.8	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL73410	204619	None	0	Human	Binding	pKi	=	7.5	7.5	2	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	344	4	0	4	2.8	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C)CC1	10.1016/s0960-894x(00)00438-8
	44382247	30499	None	0	Human	Binding	pKi	=	7.5	7.5	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	634	7	0	8	5.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)c4cccc5ccccc45)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
	CHEMBL139311	30499	None	0	Human	Binding	pKi	=	7.5	7.5	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	634	7	0	8	5.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)c4cccc5ccccc45)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
	44325051	111695	None	0	Human	Binding	pKi	=	7.5	7.5	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	546	8	0	7	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc([S+]([O-])c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328659	111695	None	0	Human	Binding	pKi	=	7.5	7.5	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	546	8	0	7	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc([S+]([O-])c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	10623721	38349	None	0	Human	Binding	pKi	=	5.5	5.5	-162	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	457	7	3	4	3.5	NCc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	CHEMBL146307	38349	None	0	Human	Binding	pKi	=	5.5	5.5	-162	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	457	7	3	4	3.5	NCc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	237	204863	None	48	Human	Binding	pKi	=	6.5	6.5	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL546257	204863	None	48	Human	Binding	pKi	=	6.5	6.5	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL554190	204863	None	48	Human	Binding	pKi	=	6.5	6.5	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL7568	204863	None	48	Human	Binding	pKi	=	6.5	6.5	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	15050951	164923	None	0	Rat	Binding	pKi	=	4.5	4.5	1	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	493	8	3	7	0.6	CC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL422407	164923	None	0	Rat	Binding	pKi	=	4.5	4.5	1	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	493	8	3	7	0.6	CC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	162353381	180027	None	0	Human	Binding	pKi	=	5.5	5.5	-3	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4747438	180027	None	0	Human	Binding	pKi	=	5.5	5.5	-3	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	462395	115200	None	1	Human	Binding	pKi	=	6.5	6.5	-128	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	558	4	0	4	5.4	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)c[n+]([O-])cc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
	CHEMBL334470	115200	None	1	Human	Binding	pKi	=	6.5	6.5	-128	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	558	4	0	4	5.4	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)c[n+]([O-])cc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
	422063	196075	None	2	Human	Binding	pKi	=	6.5	6.5	-2	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL2377384	196075	None	2	Human	Binding	pKi	=	6.5	6.5	-2	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL560649	196075	None	2	Human	Binding	pKi	=	6.5	6.5	-2	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	44443724	93987	None	0	Rat	Binding	pKi	=	6.5	6.5	-51	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.1	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL248614	93987	None	0	Rat	Binding	pKi	=	6.5	6.5	-51	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.1	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCCC1	10.1016/j.bmcl.2007.06.081
	456319	204074	None	1	Human	Binding	pKi	=	7.5	7.5	-	1	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	539	6	0	5	5.7	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL70124	204074	None	1	Human	Binding	pKi	=	7.5	7.5	-	1	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	539	6	0	5	5.7	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	44296053	189654	None	0	Human	Binding	pKi	=	7.5	7.5	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	539	6	1	5	4.7	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccccc5Cl)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL51515	189654	None	0	Human	Binding	pKi	=	7.5	7.5	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	539	6	1	5	4.7	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccccc5Cl)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	205895	11866	None	2	Rat	Binding	pKi	=	6.5	6.5	1	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	CHEMBL118240	11866	None	2	Rat	Binding	pKi	=	6.5	6.5	1	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	155565770	175622	None	0	Human	Binding	pKi	=	6.5	6.5	-5	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	410	7	0	5	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1OC	10.1016/j.bmcl.2018.12.022
	CHEMBL4580590	175622	None	0	Human	Binding	pKi	=	6.5	6.5	-5	4	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	410	7	0	5	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1OC	10.1016/j.bmcl.2018.12.022
	11567493	201800	None	13	Rat	Binding	pKi	=	5.5	5.5	-15	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL606902	201800	None	13	Rat	Binding	pKi	=	5.5	5.5	-15	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
	461838	203646	None	1	Human	Binding	pKi	=	6.5	6.5	-1	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	611	6	0	7	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(F)cccc3F)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	CHEMBL67281	203646	None	1	Human	Binding	pKi	=	6.5	6.5	-1	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	611	6	0	7	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(F)cccc3F)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	44382858	59214	None	0	Human	Binding	pKi	=	6.5	6.5	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	333	4	0	3	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL170205	59214	None	0	Human	Binding	pKi	=	6.5	6.5	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	333	4	0	3	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	145963288	161613	None	0	Human	Binding	pKi	=	6.5	6.5	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	CHEMBL4129723	161613	None	0	Human	Binding	pKi	=	6.5	6.5	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	56672197	66560	None	0	Human	Binding	pKi	=	5.5	5.5	-2	3	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
	CHEMBL1824785	66560	None	0	Human	Binding	pKi	=	5.5	5.5	-2	3	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
	CHEMBL1852489	66560	None	0	Human	Binding	pKi	=	5.5	5.5	-2	3	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
	44450621	95830	None	0	Human	Binding	pKi	=	5.5	5.5	3	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	CHEMBL258906	95830	None	0	Human	Binding	pKi	=	5.5	5.5	3	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	57664406	2396	None	50	Human	Binding	pKi	=	5.5	5.5	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	6938	2396	None	50	Human	Binding	pKi	=	5.5	5.5	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089376	2396	None	50	Human	Binding	pKi	=	5.5	5.5	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	162353375	179893	None	0	Human	Binding	pKi	=	5.5	5.5	4	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4745885	179893	None	0	Human	Binding	pKi	=	5.5	5.5	4	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	44448575	11915	None	0	Human	Binding	pKi	=	4.5	4.5	-4	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182650	11915	None	0	Human	Binding	pKi	=	4.5	4.5	-4	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL258161	11915	None	0	Human	Binding	pKi	=	4.5	4.5	-4	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	73355419	92547	None	0	Human	Binding	pKi	=	5.5	5.5	-3	5	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	4	0	2	2.7	CN(CCc1ccccn1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	CHEMBL2432059	92547	None	0	Human	Binding	pKi	=	5.5	5.5	-3	5	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	4	0	2	2.7	CN(CCc1ccccn1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	44400800	165808	None	0	Rat	Binding	pKi	=	5.5	5.5	-1	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	366	5	2	3	2.5	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL424832	165808	None	0	Rat	Binding	pKi	=	5.5	5.5	-1	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	366	5	2	3	2.5	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
	44312455	204558	None	0	Human	Binding	pKi	=	7.4	7.4	2	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	490	6	0	6	3.9	CC(c1ccc(S(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL72956	204558	None	0	Human	Binding	pKi	=	7.4	7.4	2	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	490	6	0	6	3.9	CC(c1ccc(S(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	154734599	2501	None	12	Human	Binding	pKi	=	7.4	7.4	1	12	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	327	2501	None	12	Human	Binding	pKi	=	7.4	7.4	1	12	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	4108	2501	None	12	Human	Binding	pKi	=	7.4	7.4	1	12	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	7.4	7.4	1	12	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	1687	104407	None	20	Rat	Binding	pKi	=	7.4	7.4	-15	5	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	CHEMBL310310	104407	None	20	Rat	Binding	pKi	=	7.4	7.4	-15	5	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	CHEMBL540034	104407	None	20	Rat	Binding	pKi	=	7.4	7.4	-15	5	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	44318736	107019	None	0	Human	Binding	pKi	=	6.4	6.4	-2	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
	CHEMBL315428	107019	None	0	Human	Binding	pKi	=	6.4	6.4	-2	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
	44318766	205749	None	0	Human	Binding	pKi	=	5.4	5.4	-4	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
	CHEMBL82754	205749	None	0	Human	Binding	pKi	=	5.4	5.4	-4	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
	44308798	204045	None	0	Human	Binding	pKi	=	4.4	4.4	-19	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	434	6	1	3	4.4	O=C(N1CCC(CCN2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL69904	204045	None	0	Human	Binding	pKi	=	4.4	4.4	-19	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	434	6	1	3	4.4	O=C(N1CCC(CCN2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	10925451	58770	None	0	Human	Binding	pKi	=	6.4	6.4	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2ccc(Cl)cc21)c1ccccn1	10.1021/jm020895l
	CHEMBL168707	58770	None	0	Human	Binding	pKi	=	6.4	6.4	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2ccc(Cl)cc21)c1ccccn1	10.1021/jm020895l
	25067048	12331	None	0	Human	Binding	pKi	=	6.4	6.4	-28	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1185245	12331	None	0	Human	Binding	pKi	=	6.4	6.4	-28	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL402207	12331	None	0	Human	Binding	pKi	=	6.4	6.4	-28	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	44627855	197369	None	0	Human	Binding	pKi	=	6.4	6.4	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569212	197369	None	0	Human	Binding	pKi	=	6.4	6.4	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	162353377	181163	None	0	Human	Binding	pKi	=	5.4	5.4	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760904	181163	None	0	Human	Binding	pKi	=	5.4	5.4	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	162353372	181385	None	0	Human	Binding	pKi	=	5.4	5.4	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4763422	181385	None	0	Human	Binding	pKi	=	5.4	5.4	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	71450996	79685	None	0	Rat	Binding	pKi	=	5.4	5.4	-3	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL2115361	79685	None	0	Rat	Binding	pKi	=	5.4	5.4	-3	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	10408304	103442	None	0	Rat	Binding	pKi	=	6.4	6.4	-11	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	393	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
	CHEMBL3084896	103442	None	0	Rat	Binding	pKi	=	6.4	6.4	-11	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	393	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
	13773342	79680	None	0	Rat	Binding	pKi	=	7.4	7.4	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2115341	79680	None	0	Rat	Binding	pKi	=	7.4	7.4	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	44312081	204245	None	0	Human	Binding	pKi	=	7.4	7.4	1	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	330	4	1	4	2.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCNCC1	10.1016/s0960-894x(00)00438-8
	CHEMBL71088	204245	None	0	Human	Binding	pKi	=	7.4	7.4	1	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	330	4	1	4	2.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCNCC1	10.1016/s0960-894x(00)00438-8
	2774	3866	None	95	Human	Binding	pKi	=	7.4	7.4	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	5593	3866	None	95	Human	Binding	pKi	=	7.4	7.4	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	7319	3866	None	95	Human	Binding	pKi	=	7.4	7.4	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	CHEMBL1200604	3866	None	95	Human	Binding	pKi	=	7.4	7.4	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	DB00809	3866	None	95	Human	Binding	pKi	=	7.4	7.4	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	DB01199	3866	None	95	Human	Binding	pKi	=	7.4	7.4	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	10646948	37880	None	0	Human	Binding	pKi	=	7.4	7.4	-30	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	4	3.8	O=C(NC1CCN(Cc2cccc(O)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL145913	37880	None	0	Human	Binding	pKi	=	7.4	7.4	-30	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	4	3.8	O=C(NC1CCN(Cc2cccc(O)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	44379281	57544	None	0	Human	Binding	pKi	=	7.4	7.4	1	3	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	506	9	1	5	5.3	CCOC(=O)N(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
	CHEMBL166385	57544	None	0	Human	Binding	pKi	=	7.4	7.4	1	3	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	506	9	1	5	5.3	CCOC(=O)N(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
	10041771	103430	None	0	Rat	Binding	pKi	=	7.4	7.4	-13	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	321	4	0	2	4.7	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	CHEMBL3084881	103430	None	0	Rat	Binding	pKi	=	7.4	7.4	-13	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	321	4	0	2	4.7	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	16086004	139235	None	0	Human	Binding	pKi	=	5.4	5.4	-1000	3	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	CHEMBL378885	139235	None	0	Human	Binding	pKi	=	5.4	5.4	-1000	3	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	25070031	65383	None	18	Human	Binding	pKi	=	5.4	5.4	-1862	4	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	313	6	1	4	2.7	C[C@@H]1CCCN1CCCOc1ccc(-c2ccc(=O)[nH]n2)cc1	10.1021/jm200401v
	CHEMBL1829335	65383	None	18	Human	Binding	pKi	=	5.4	5.4	-1862	4	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	313	6	1	4	2.7	C[C@@H]1CCCN1CCCOc1ccc(-c2ccc(=O)[nH]n2)cc1	10.1021/jm200401v
	10397468	188962	None	2	Rat	Binding	pKi	=	4.4	4.4	-1	2	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	CHEMBL50831	188962	None	2	Rat	Binding	pKi	=	4.4	4.4	-1	2	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	10501523	40519	None	0	Human	Binding	pKi	=	4.4	4.4	-169	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccccc1CN1CCC(NC(=O)C(O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
	CHEMBL148310	40519	None	0	Human	Binding	pKi	=	4.4	4.4	-169	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccccc1CN1CCC(NC(=O)C(O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
	10951142	5220	None	0	Human	Binding	pKi	=	6.4	6.4	-7	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	496	6	0	6	5.9	CCOC(=O)c1c(CC)n(Cc2ccccc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL106219	5220	None	0	Human	Binding	pKi	=	6.4	6.4	-7	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	496	6	0	6	5.9	CCOC(=O)c1c(CC)n(Cc2ccccc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	24894628	179121	None	0	Human	Binding	pKi	=	5.4	5.4	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
	CHEMBL471942	179121	None	0	Human	Binding	pKi	=	5.4	5.4	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
	CHEMBL554532	179121	None	0	Human	Binding	pKi	=	5.4	5.4	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
	1273	1752	None	16	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	3450	1752	None	16	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	356	1752	None	16	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	6172	1752	None	16	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	67425	1752	None	16	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	CHEMBL360055	1752	None	16	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	DB00483	1752	None	16	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	24865895	96003	None	0	Human	Binding	pKi	=	4.4	4.4	1	5	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL259662	96003	None	0	Human	Binding	pKi	=	4.4	4.4	1	5	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL390842	96003	None	0	Human	Binding	pKi	=	4.4	4.4	1	5	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	1224	1431	None	83	Human	Binding	pKi	=	6.4	6.4	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	3100	1431	None	83	Human	Binding	pKi	=	6.4	6.4	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	8980	1431	None	83	Human	Binding	pKi	=	6.4	6.4	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	916	1431	None	83	Human	Binding	pKi	=	6.4	6.4	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	CHEMBL657	1431	None	83	Human	Binding	pKi	=	6.4	6.4	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	DB01075	1431	None	83	Human	Binding	pKi	=	6.4	6.4	-6	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	44382840	120736	None	0	Human	Binding	pKi	=	6.4	6.4	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	363	4	0	4	3.9	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC(C)O1	10.1016/s0960-894x(99)00101-8
	CHEMBL354934	120736	None	0	Human	Binding	pKi	=	6.4	6.4	1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	363	4	0	4	3.9	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC(C)O1	10.1016/s0960-894x(99)00101-8
	2200	3129	None	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	328	3129	None	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	4848	3129	None	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	DB00670	3129	None	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	44437227	11876	None	0	Human	Binding	pKi	=	5.4	5.4	-3	2	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
	CHEMBL1182447	11876	None	0	Human	Binding	pKi	=	5.4	5.4	-3	2	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
	CHEMBL239017	11876	None	0	Human	Binding	pKi	=	5.4	5.4	-3	2	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
	124087	1388	None	114	Human	Binding	pKi	=	7.4	7.4	-6	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	7157	1388	None	114	Human	Binding	pKi	=	7.4	7.4	-6	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	814	1388	None	114	Human	Binding	pKi	=	7.4	7.4	-6	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	CHEMBL1172	1388	None	114	Human	Binding	pKi	=	7.4	7.4	-6	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	DB00967	1388	None	114	Human	Binding	pKi	=	7.4	7.4	-6	15	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	100	3803	None	58	Human	Binding	pKi	=	7.4	7.4	-19	55	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2637	3803	None	58	Human	Binding	pKi	=	7.4	7.4	-19	55	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	5452	3803	None	58	Human	Binding	pKi	=	7.4	7.4	-19	55	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	CHEMBL479	3803	None	58	Human	Binding	pKi	=	7.4	7.4	-19	55	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	DB00679	3803	None	58	Human	Binding	pKi	=	7.4	7.4	-19	55	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2733638	11912	None	2	Human	Binding	pKi	=	7.4	7.4	-1	5	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	6508731	11912	None	2	Human	Binding	pKi	=	7.4	7.4	-1	5	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	8030329	11912	None	2	Human	Binding	pKi	=	7.4	7.4	-1	5	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	CHEMBL1182640	11912	None	2	Human	Binding	pKi	=	7.4	7.4	-1	5	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	CHEMBL257643	11912	None	2	Human	Binding	pKi	=	7.4	7.4	-1	5	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	2551	793	None	23	Human	Binding	pKi	=	7.4	7.4	-6	11	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	298	793	None	23	Human	Binding	pKi	=	7.4	7.4	-6	11	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	488	793	None	23	Human	Binding	pKi	=	7.4	7.4	-6	11	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	CHEMBL965	793	None	23	Human	Binding	pKi	=	7.4	7.4	-6	11	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	DB00411	793	None	23	Human	Binding	pKi	=	7.4	7.4	-6	11	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	44593620	187934	None	0	Human	Binding	pKi	=	7.4	7.4	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496915	187934	None	0	Human	Binding	pKi	=	7.4	7.4	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	187	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	10248845	122769	None	0	Rat	Binding	pKi	=	6.4	6.4	-3	2	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	374	6	0	3	3.1	CCN(CC)CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
	CHEMBL360491	122769	None	0	Rat	Binding	pKi	=	6.4	6.4	-3	2	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	374	6	0	3	3.1	CCN(CC)CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
	3652	4095	None	79	Human	Binding	pKi	=	6.4	6.4	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4095	None	79	Human	Binding	pKi	=	6.4	6.4	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4095	None	79	Human	Binding	pKi	=	6.4	6.4	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	6.4	6.4	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4095	None	79	Human	Binding	pKi	=	6.4	6.4	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	187	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	14964507	114353	None	1	Rat	Binding	pKi	=	5.4	5.4	-5	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL333107	114353	None	1	Rat	Binding	pKi	=	5.4	5.4	-5	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	10443767	13880	None	1	Rat	Binding	pKi	=	4.4	4.4	-3	2	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
	CHEMBL1196108	13880	None	1	Rat	Binding	pKi	=	4.4	4.4	-3	2	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
	CHEMBL555955	13880	None	1	Rat	Binding	pKi	=	4.4	4.4	-3	2	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
	9911615	99029	None	0	Human	Binding	pKi	=	5.4	5.4	-1905	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	5	0	6	5.5	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(SC)cc2CCN1C3	10.1021/jm011116o
	CHEMBL280220	99029	None	0	Human	Binding	pKi	=	5.4	5.4	-1905	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	5	0	6	5.5	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(SC)cc2CCN1C3	10.1021/jm011116o
	44286172	144471	None	0	Rat	Binding	pKi	=	4.4	4.4	1	2	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	166	2	1	2	-0.2	CNCC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL39067	144471	None	0	Rat	Binding	pKi	=	4.4	4.4	1	2	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	166	2	1	2	-0.2	CNCC#CCN1CCCC1=O	10.1021/jm00087a008
	135	2530	None	43	Human	Binding	pKi	=	6.4	6.4	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	1796	2530	None	43	Human	Binding	pKi	=	6.4	6.4	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	4184	2530	None	43	Human	Binding	pKi	=	6.4	6.4	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	CHEMBL6437	2530	None	43	Human	Binding	pKi	=	6.4	6.4	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	DB06148	2530	None	43	Human	Binding	pKi	=	6.4	6.4	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	2284	3180	None	33	Human	Binding	pKi	=	6.4	6.4	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	4926	3180	None	33	Human	Binding	pKi	=	6.4	6.4	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	7281	3180	None	33	Human	Binding	pKi	=	6.4	6.4	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	CHEMBL564	3180	None	33	Human	Binding	pKi	=	6.4	6.4	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	DB00420	3180	None	33	Human	Binding	pKi	=	6.4	6.4	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	108993425	181756	None	1	Human	Binding	pKi	=	6.4	6.4	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4777543	181756	None	1	Human	Binding	pKi	=	6.4	6.4	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	44274477	165566	None	0	Human	Binding	pKi	=	4.4	4.4	-1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	331	2	0	3	2.8	CN1CCN(C(=O)C2=C/C(=C\c3ccncc3)c3ccccc32)CC1	10.1016/s0960-894x(01)00186-x
	CHEMBL424214	165566	None	0	Human	Binding	pKi	=	4.4	4.4	-1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	331	2	0	3	2.8	CN1CCN(C(=O)C2=C/C(=C\c3ccncc3)c3ccccc32)CC1	10.1016/s0960-894x(01)00186-x
	11595794	135699	None	0	Rat	Binding	pKi	=	7.4	7.4	-3	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
	CHEMBL372983	135699	None	0	Rat	Binding	pKi	=	7.4	7.4	-3	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
	59291324	112776	None	0	Rat	Binding	pKi	=	7.4	7.4	-4	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298593	112776	None	0	Rat	Binding	pKi	=	7.4	7.4	-4	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305622	112776	None	0	Rat	Binding	pKi	=	7.4	7.4	-4	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	44443730	94031	None	0	Rat	Binding	pKi	=	7.4	7.4	-21	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	6	2	3	4.7	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL248811	94031	None	0	Rat	Binding	pKi	=	7.4	7.4	-21	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	6	2	3	4.7	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	10340096	103431	None	0	Rat	Binding	pKi	=	7.4	7.4	-10	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	385	4	0	2	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
	CHEMBL3084882	103431	None	0	Rat	Binding	pKi	=	7.4	7.4	-10	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	385	4	0	2	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
	10269809	159379	None	0	Human	Binding	pKi	=	7.4	7.4	-2	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	345	3	0	2	4.1	COC1(C#CC(C)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL410061	159379	None	0	Human	Binding	pKi	=	7.4	7.4	-2	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	345	3	0	2	4.1	COC1(C#CC(C)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	44593616	193212	None	0	Human	Binding	pKi	=	7.4	7.4	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL523518	193212	None	0	Human	Binding	pKi	=	7.4	7.4	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	167962	4067	None	4	Human	Binding	pKi	=	7.4	7.4	-	1	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4067	None	4	Human	Binding	pKi	=	7.4	7.4	-	1	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4067	None	4	Human	Binding	pKi	=	7.4	7.4	-	1	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	44418764	82157	None	0	Human	Binding	pKi	=	7.4	7.4	-1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	CHEMBL216928	82157	None	0	Human	Binding	pKi	=	7.4	7.4	-1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	16094791	83255	None	0	Human	Binding	pKi	=	7.4	7.4	1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL218755	83255	None	0	Human	Binding	pKi	=	7.4	7.4	1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	16094783	136565	None	0	Human	Binding	pKi	=	7.4	7.4	1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL373888	136565	None	0	Human	Binding	pKi	=	7.4	7.4	1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	15196234	118503	None	3	Human	Binding	pKi	=	6.4	6.4	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccco2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL341476	118503	None	3	Human	Binding	pKi	=	6.4	6.4	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccco2)C2CCN1CC2	10.1021/jm00003a011
	3941250	13335	None	19	Rat	Binding	pKi	=	6.4	6.4	-70	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1192187	13335	None	19	Rat	Binding	pKi	=	6.4	6.4	-70	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
	CHEMBL543382	13335	None	19	Rat	Binding	pKi	=	6.4	6.4	-70	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
	187	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	39	Human	Binding	pKi	=	6.4	6.4	6	9	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44309090	203747	None	0	Human	Binding	pKi	=	5.4	5.4	-43	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	6	3	3	2.8	O=C(NCCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL67873	203747	None	0	Human	Binding	pKi	=	5.4	5.4	-43	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	6	3	3	2.8	O=C(NCCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	137644950	158490	None	0	Human	Binding	pKi	=	4.4	4.4	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	3	1.6	CN1CCC(COCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091032	158490	None	0	Human	Binding	pKi	=	4.4	4.4	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	3	1.6	CN1CCC(COCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	11099206	120785	None	0	Human	Binding	pKi	=	6.4	6.4	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	318	5	0	2	4.7	CC(C1=C(CCN2CCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL355455	120785	None	0	Human	Binding	pKi	=	6.4	6.4	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	318	5	0	2	4.7	CC(C1=C(CCN2CCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	44319008	205760	None	0	Human	Binding	pKi	=	6.4	6.4	-2	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	4	0	2	4.5	CC(=O)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL82850	205760	None	0	Human	Binding	pKi	=	6.4	6.4	-2	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	4	0	2	4.5	CC(=O)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44339685	110462	None	0	Rat	Binding	pKi	=	6.4	6.4	1	2	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	CHEMBL324725	110462	None	0	Rat	Binding	pKi	=	6.4	6.4	1	2	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	9978073	94066	None	0	Rat	Binding	pKi	=	5.4	5.4	-7	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	396	6	2	4	3.4	O=C(N[C@H]1[C@@H]2CN(Cc3cccs3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL249005	94066	None	0	Rat	Binding	pKi	=	5.4	5.4	-7	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	396	6	2	4	3.4	O=C(N[C@H]1[C@@H]2CN(Cc3cccs3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	44448385	11908	None	0	Human	Binding	pKi	=	5.4	5.4	-3	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182633	11908	None	0	Human	Binding	pKi	=	5.4	5.4	-3	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL257174	11908	None	0	Human	Binding	pKi	=	5.4	5.4	-3	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	44318781	106976	None	0	Human	Binding	pKi	=	5.4	5.4	-5	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	415	6	0	4	4.9	O=C(c1ccc([N+](=O)[O-])cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL315127	106976	None	0	Human	Binding	pKi	=	5.4	5.4	-5	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	415	6	0	4	4.9	O=C(c1ccc([N+](=O)[O-])cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11759058	120847	None	0	Human	Binding	pKi	=	4.4	4.4	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL355851	120847	None	0	Human	Binding	pKi	=	4.4	4.4	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	57326146	77185	None	0	Human	Binding	pKi	=	4.4	4.4	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042403	77185	None	0	Human	Binding	pKi	=	4.4	4.4	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2079020	77185	None	0	Human	Binding	pKi	=	4.4	4.4	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
	2551	793	None	23	Rat	Binding	pKi	=	8.4	8.4	-3	11	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	298	793	None	23	Rat	Binding	pKi	=	8.4	8.4	-3	11	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	488	793	None	23	Rat	Binding	pKi	=	8.4	8.4	-3	11	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL965	793	None	23	Rat	Binding	pKi	=	8.4	8.4	-3	11	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	DB00411	793	None	23	Rat	Binding	pKi	=	8.4	8.4	-3	11	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	55005	104773	None	8	Rat	Binding	pKi	=	8.4	8.4	-1	3	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL310852	104773	None	8	Rat	Binding	pKi	=	8.4	8.4	-1	3	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	2705	3840	None	64	Human	Binding	pKi	=	8.4	8.4	-1	10	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	360	3840	None	64	Human	Binding	pKi	=	8.4	8.4	-1	10	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	443879	3840	None	64	Human	Binding	pKi	=	8.4	8.4	-1	10	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	CHEMBL1382	3840	None	64	Human	Binding	pKi	=	8.4	8.4	-1	10	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	DB01036	3840	None	64	Human	Binding	pKi	=	8.4	8.4	-1	10	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	44406662	166281	None	0	Human	Binding	pKi	=	8.4	8.4	-12	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2ccc(F)nc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL427013	166281	None	0	Human	Binding	pKi	=	8.4	8.4	-12	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2ccc(F)nc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44378914	120028	None	0	Rat	Binding	pKi	=	8.4	8.4	-	1	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
	CHEMBL350332	120028	None	0	Rat	Binding	pKi	=	8.4	8.4	-	1	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
	155560013	176298	None	0	Human	Binding	pKi	=	8.4	8.4	6	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4564922	176298	None	0	Human	Binding	pKi	=	8.4	8.4	6	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595198	176298	None	0	Human	Binding	pKi	=	8.4	8.4	6	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	44593618	187457	None	0	Human	Binding	pKi	=	8.4	8.4	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493979	187457	None	0	Human	Binding	pKi	=	8.4	8.4	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	10073079	101518	None	0	Rat	Binding	pKi	=	8.4	8.4	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
	CHEMBL298085	101518	None	0	Rat	Binding	pKi	=	8.4	8.4	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
	16115798	137876	None	0	Human	Binding	pKi	=	8.4	8.4	-3	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL376255	137876	None	0	Human	Binding	pKi	=	8.4	8.4	-3	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	155516383	176671	None	0	Human	Binding	pKi	=	8.4	8.4	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4443219	176671	None	0	Human	Binding	pKi	=	8.4	8.4	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4598230	176671	None	0	Human	Binding	pKi	=	8.4	8.4	5	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	129989	451	None	51	Human	Binding	pKi	=	8.4	8.4	-1	9	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	8584	451	None	51	Human	Binding	pKi	=	8.4	8.4	-1	9	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	CHEMBL43383	451	None	51	Human	Binding	pKi	=	8.4	8.4	-1	9	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	14939893	9532	None	0	Rat	Binding	pKi	=	8.4	8.4	-1	5	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112244	9532	None	0	Rat	Binding	pKi	=	8.4	8.4	-1	5	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44267730	16485	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	534	7	0	5	5.8	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12354	16485	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	534	7	0	5	5.8	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44383653	120849	None	0	Human	Binding	pKi	=	8.4	8.4	-1	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL355854	120849	None	0	Human	Binding	pKi	=	8.4	8.4	-1	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	44378982	57578	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	632	7	1	8	4.6	CC(=O)Nc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL166685	57578	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	632	7	1	8	4.6	CC(=O)Nc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	16115799	83440	None	0	Human	Binding	pKi	=	8.4	8.4	-4	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL219825	83440	None	0	Human	Binding	pKi	=	8.4	8.4	-4	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	156015254	178285	None	0	Human	Binding	pKi	=	8.4	8.4	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4649420	178285	None	0	Human	Binding	pKi	=	8.4	8.4	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650938	178285	None	0	Human	Binding	pKi	=	8.4	8.4	3	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	70681307	74454	None	0	Human	Binding	pKi	=	8.4	8.4	2	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2021479	74454	None	0	Human	Binding	pKi	=	8.4	8.4	2	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2027890	74454	None	0	Human	Binding	pKi	=	8.4	8.4	2	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	10365639	120857	None	0	Human	Binding	pKi	=	8.4	8.4	1	2	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	434	8	2	4	4.4	CCNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
	CHEMBL355874	120857	None	0	Human	Binding	pKi	=	8.4	8.4	1	2	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	434	8	2	4	4.4	CCNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
	324	1923	None	15	Human	Binding	pKi	=	8.4	8.4	-1	9	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
	6436265	1923	None	15	Human	Binding	pKi	=	8.4	8.4	-1	9	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
	CHEMBL277642	1923	None	15	Human	Binding	pKi	=	8.4	8.4	-1	9	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
	11968014	12756	None	5	Rat	Binding	pKi	=	8.3	8.3	-3	9	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm960374w
	119680147	12756	None	5	Rat	Binding	pKi	=	8.3	8.3	-3	9	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm960374w
	CHEMBL1187846	12756	None	5	Rat	Binding	pKi	=	8.3	8.3	-3	9	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm960374w
	DB00747	12756	None	5	Rat	Binding	pKi	=	8.3	8.3	-3	9	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm960374w
	154417	93258	None	60	Human	Binding	pKi	=	8.3	8.3	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL1331216	93258	None	60	Human	Binding	pKi	=	8.3	8.3	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL2449003	93258	None	60	Human	Binding	pKi	=	8.3	8.3	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	DB00424	93258	None	60	Human	Binding	pKi	=	8.3	8.3	-18	9	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	44627853	197679	None	0	Human	Binding	pKi	=	8.3	8.3	-3	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL571121	197679	None	0	Human	Binding	pKi	=	8.3	8.3	-3	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	324	1923	None	15	Human	Binding	pKi	=	8.3	8.3	-1	9	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	6436265	1923	None	15	Human	Binding	pKi	=	8.3	8.3	-1	9	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	CHEMBL277642	1923	None	15	Human	Binding	pKi	=	8.3	8.3	-1	9	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	44378599	58136	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c2c1OCO2	10.1016/s0960-894x(02)00024-0
	CHEMBL167839	58136	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c2c1OCO2	10.1016/s0960-894x(02)00024-0
	44344075	110487	None	0	Rat	Binding	pKi	=	8.3	8.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	608	7	0	7	4.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL324832	110487	None	0	Rat	Binding	pKi	=	8.3	8.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	608	7	0	7	4.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	16115950	136380	None	0	Human	Binding	pKi	=	8.3	8.3	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL373515	136380	None	0	Human	Binding	pKi	=	8.3	8.3	-1	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	14210083	156710	None	1	Human	Binding	pKi	=	8.3	8.3	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4070155	156710	None	1	Human	Binding	pKi	=	8.3	8.3	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
	174174	523	None	49	Human	Binding	pKi	=	8.3	8.3	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	523	None	49	Human	Binding	pKi	=	8.3	8.3	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	523	None	49	Human	Binding	pKi	=	8.3	8.3	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.3	8.3	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	523	None	49	Human	Binding	pKi	=	8.3	8.3	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	10104167	2057	None	2	Human	Binding	pKi	=	8.3	8.3	13	4	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	6937	2057	None	2	Human	Binding	pKi	=	8.3	8.3	13	4	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL3121473	2057	None	2	Human	Binding	pKi	=	8.3	8.3	13	4	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	44400180	69006	None	0	Rat	Binding	pKi	=	7.4	7.4	-1	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	397	5	1	4	2.7	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
	CHEMBL192337	69006	None	0	Rat	Binding	pKi	=	7.4	7.4	-1	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	397	5	1	4	2.7	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
	44296022	194922	None	0	Human	Binding	pKi	=	7.4	7.4	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	498	6	1	4	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL54155	194922	None	0	Human	Binding	pKi	=	7.4	7.4	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	498	6	1	4	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44267734	10528	None	0	Human	Binding	pKi	=	7.4	7.4	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	5	6.1	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11690	10528	None	0	Human	Binding	pKi	=	7.4	7.4	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	5	6.1	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44406316	72720	None	0	Human	Binding	pKi	=	7.4	7.4	-15	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	341	6	1	3	3.6	CCCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
	CHEMBL199821	72720	None	0	Human	Binding	pKi	=	7.4	7.4	-15	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	341	6	1	3	3.6	CCCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
	44406689	141283	None	0	Human	Binding	pKi	=	7.4	7.4	-5	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cccnn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL383248	141283	None	0	Human	Binding	pKi	=	7.4	7.4	-5	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cccnn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44299477	100715	None	0	Human	Binding	pKi	=	7.4	7.4	95	2	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	191	2	0	4	0.6	c1cnc(O[C@@H]2CN3CCC2C3)cn1	10.1016/s0960-894x(99)00313-3
	CHEMBL292574	100715	None	0	Human	Binding	pKi	=	7.4	7.4	95	2	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	191	2	0	4	0.6	c1cnc(O[C@@H]2CN3CCC2C3)cn1	10.1016/s0960-894x(99)00313-3
	18342968	167967	None	0	Human	Binding	pKi	=	7.4	7.4	6	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	455	7	1	5	3.3	COc1ccc([S+]([O-])c2ccc(C(C(N)=O)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL431787	167967	None	0	Human	Binding	pKi	=	7.4	7.4	6	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	455	7	1	5	3.3	COc1ccc([S+]([O-])c2ccc(C(C(N)=O)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	44437270	12326	None	0	Human	Binding	pKi	=	7.4	7.4	13	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
	CHEMBL1185211	12326	None	0	Human	Binding	pKi	=	7.4	7.4	13	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
	CHEMBL398043	12326	None	0	Human	Binding	pKi	=	7.4	7.4	13	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
	2230	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	296	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	CHEMBL7303	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	DB04365	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	2230	465	None	60	Rat	Binding	pKi	=	7.4	7.4	-107	10	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	296	465	None	60	Rat	Binding	pKi	=	7.4	7.4	-107	10	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	CHEMBL7303	465	None	60	Rat	Binding	pKi	=	7.4	7.4	-107	10	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	DB04365	465	None	60	Rat	Binding	pKi	=	7.4	7.4	-107	10	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	2230	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	296	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	CHEMBL7303	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	DB04365	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	2230	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	296	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	CHEMBL7303	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	DB04365	465	None	60	Human	Binding	pKi	=	7.4	7.4	-75	10	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	118710666	120827	None	0	Human	Binding	pKi	=	7.4	7.4	-4	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323282	120827	None	0	Human	Binding	pKi	=	7.4	7.4	-4	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558210	120827	None	0	Human	Binding	pKi	=	7.4	7.4	-4	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	164627658	188607	None	0	Human	Binding	pKi	=	7.4	7.4	20	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4875268	188607	None	0	Human	Binding	pKi	=	7.4	7.4	20	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5029013	188607	None	0	Human	Binding	pKi	=	7.4	7.4	20	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	10242813	36475	None	0	Human	Binding	pKi	=	6.4	6.4	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	226	1	0	3	2.9	C1=C(c2nc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL144751	36475	None	0	Human	Binding	pKi	=	6.4	6.4	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	226	1	0	3	2.9	C1=C(c2nc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
	15169865	11261	None	0	Rat	Binding	pKi	=	5.4	5.4	5	3	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL1179079	11261	None	0	Rat	Binding	pKi	=	5.4	5.4	5	3	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL59085	11261	None	0	Rat	Binding	pKi	=	5.4	5.4	5	3	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	68764898	671	None	2	Human	Binding	pKi	=	5.4	5.4	-11	3	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
	9430	671	None	2	Human	Binding	pKi	=	5.4	5.4	-11	3	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
	CHEMBL3577945	671	None	2	Human	Binding	pKi	=	5.4	5.4	-11	3	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
	167962	4067	None	4	Human	Binding	pKi	=	6.4	6.4	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4067	None	4	Human	Binding	pKi	=	6.4	6.4	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4067	None	4	Human	Binding	pKi	=	6.4	6.4	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	72190450	92273	None	0	Human	Binding	pKi	=	6.4	6.4	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426679	92273	None	0	Human	Binding	pKi	=	6.4	6.4	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	109032820	182873	None	1	Human	Binding	pKi	=	6.4	6.4	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4791819	182873	None	1	Human	Binding	pKi	=	6.4	6.4	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	156015045	178263	None	0	Human	Binding	pKi	=	6.4	6.4	17	3	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4648218	178263	None	0	Human	Binding	pKi	=	6.4	6.4	17	3	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650765	178263	None	0	Human	Binding	pKi	=	6.4	6.4	17	3	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	11729182	5229	None	0	Human	Binding	pKi	=	5.4	5.4	2	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	405	3	1	4	4.0	CCN(C)C(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL106259	5229	None	0	Human	Binding	pKi	=	5.4	5.4	2	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	405	3	1	4	4.0	CCN(C)C(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	162353387	181229	None	0	Human	Binding	pKi	=	4.4	4.4	2	2	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4761549	181229	None	0	Human	Binding	pKi	=	4.4	4.4	2	2	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	162353380	182492	None	0	Human	Binding	pKi	=	4.4	4.4	1	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	259	2	0	3	1.8	O=C(CN1CCCc2cnccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4786868	182492	None	0	Human	Binding	pKi	=	4.4	4.4	1	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	259	2	0	3	1.8	O=C(CN1CCCc2cnccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	44437303	12324	None	1	Human	Binding	pKi	=	5.4	5.4	1	2	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
	CHEMBL1185162	12324	None	1	Human	Binding	pKi	=	5.4	5.4	1	2	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
	CHEMBL394329	12324	None	1	Human	Binding	pKi	=	5.4	5.4	1	2	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
	44308899	204004	None	0	Human	Binding	pKi	=	7.4	7.4	-37	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	330	5	2	3	2.7	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL69648	204004	None	0	Human	Binding	pKi	=	7.4	7.4	-37	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	330	5	2	3	2.7	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	2683	102886	None	25	Human	Binding	pKi	=	7.4	7.4	-5	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL305906	102886	None	25	Human	Binding	pKi	=	7.4	7.4	-5	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL334255	102886	None	25	Human	Binding	pKi	=	7.4	7.4	-5	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	44431376	87315	None	0	Human	Binding	pKi	=	7.4	7.4	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL233200	87315	None	0	Human	Binding	pKi	=	7.4	7.4	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	44593623	187878	None	0	Human	Binding	pKi	=	7.4	7.4	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496503	187878	None	0	Human	Binding	pKi	=	7.4	7.4	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539373	187878	None	0	Human	Binding	pKi	=	7.4	7.4	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	10428089	103445	None	0	Rat	Binding	pKi	=	7.4	7.4	-5	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	352	5	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc([N+](=O)[O-])cc1)C2	10.1021/jm00020a006
	CHEMBL3084899	103445	None	0	Rat	Binding	pKi	=	7.4	7.4	-5	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	352	5	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc([N+](=O)[O-])cc1)C2	10.1021/jm00020a006
	10330893	121119	None	0	Human	Binding	pKi	=	6.4	6.4	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	215	2	0	2	2.8	COc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL357444	121119	None	0	Human	Binding	pKi	=	6.4	6.4	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	215	2	0	2	2.8	COc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL69452	203972	None	0	Human	Binding	pKi	=	5.4	5.4	2	5	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	331	6	1	5	2.7	CCO/C(O)=C1\CN2CC(CCC2COCc2ccccc2)C1=O	10.1021/jm020572p
	2551	793	None	23	Human	Binding	pKi	=	5.4	5.4	-6	11	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	298	793	None	23	Human	Binding	pKi	=	5.4	5.4	-6	11	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	488	793	None	23	Human	Binding	pKi	=	5.4	5.4	-6	11	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL965	793	None	23	Human	Binding	pKi	=	5.4	5.4	-6	11	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB00411	793	None	23	Human	Binding	pKi	=	5.4	5.4	-6	11	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	16125505	84776	None	0	Human	Binding	pKi	=	6.4	6.4	-3	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	1	2	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL223186	84776	None	0	Human	Binding	pKi	=	6.4	6.4	-3	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	1	2	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCc2ccccc2)CC1	10.1021/jm061159a
	6726	1279	None	51	Human	Binding	pKi	=	6.4	6.4	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	7151	1279	None	51	Human	Binding	pKi	=	6.4	6.4	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	749	1279	None	51	Human	Binding	pKi	=	6.4	6.4	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL648	1279	None	51	Human	Binding	pKi	=	6.4	6.4	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB01176	1279	None	51	Human	Binding	pKi	=	6.4	6.4	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	9998508	80108	None	0	Human	Binding	pKi	=	6.4	6.4	2	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21321	80108	None	0	Human	Binding	pKi	=	6.4	6.4	2	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	54816802	181270	None	2	Human	Binding	pKi	=	6.4	6.4	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4762056	181270	None	2	Human	Binding	pKi	=	6.4	6.4	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	118719929	115781	None	0	Human	Binding	pKi	=	6.4	6.4	-3	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	442	15	1	3	6.0	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCO)CC1	10.1021/jm501173q
	CHEMBL3354076	115781	None	0	Human	Binding	pKi	=	6.4	6.4	-3	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	442	15	1	3	6.0	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCO)CC1	10.1021/jm501173q
	156015051	178326	None	0	Human	Binding	pKi	=	6.4	6.4	3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4643329	178326	None	0	Human	Binding	pKi	=	6.4	6.4	3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651139	178326	None	0	Human	Binding	pKi	=	6.4	6.4	3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	156009660	178327	None	0	Human	Binding	pKi	=	6.4	6.4	3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4634475	178327	None	0	Human	Binding	pKi	=	6.4	6.4	3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651150	178327	None	0	Human	Binding	pKi	=	6.4	6.4	3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	10982070	5164	None	0	Human	Binding	pKi	=	6.4	6.4	-2	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	2	0	6	3.7	COC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL105945	5164	None	0	Human	Binding	pKi	=	6.4	6.4	-2	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	2	0	6	3.7	COC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	137636308	156200	None	0	Human	Binding	pKi	=	5.4	5.4	-13	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	329	7	0	3	2.8	CCCCN1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4064222	156200	None	0	Human	Binding	pKi	=	5.4	5.4	-13	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	329	7	0	3	2.8	CCCCN1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	44274317	83370	None	0	Human	Binding	pKi	=	4.4	4.4	-1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21937	83370	None	0	Human	Binding	pKi	=	4.4	4.4	-1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	24894631	176762	None	3	Human	Binding	pKi	=	4.4	4.4	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCCC1c1ccco1	10.1021/jm800145d
	CHEMBL460470	176762	None	3	Human	Binding	pKi	=	4.4	4.4	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCCC1c1ccco1	10.1021/jm800145d
	10404406	100199	None	0	Rat	Binding	pKi	=	6.4	6.4	19	2	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	330	3	1	4	2.2	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCOCC1	10.1021/jm970333f
	CHEMBL288285	100199	None	0	Rat	Binding	pKi	=	6.4	6.4	19	2	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	330	3	1	4	2.2	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCOCC1	10.1021/jm970333f
	10381417	68666	None	0	Rat	Binding	pKi	=	7.4	7.4	1	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	CHEMBL192061	68666	None	0	Rat	Binding	pKi	=	7.4	7.4	1	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	14537189	162641	None	0	Rat	Binding	pKi	=	7.4	7.4	1	2	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL416974	162641	None	0	Rat	Binding	pKi	=	7.4	7.4	1	2	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	10066369	120256	None	0	Human	Binding	pKi	=	7.4	7.4	8	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL352375	120256	None	0	Human	Binding	pKi	=	7.4	7.4	8	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	44309135	96566	None	0	Human	Binding	pKi	=	5.4	5.4	-54	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	7	2	3	3.7	NCCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL263040	96566	None	0	Human	Binding	pKi	=	5.4	5.4	-54	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	7	2	3	3.7	NCCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	10467755	121098	None	2	Human	Binding	pKi	=	5.4	5.4	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2cc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL357200	121098	None	2	Human	Binding	pKi	=	5.4	5.4	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2cc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
	137628855	160968	None	0	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4103087	160968	None	0	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115966	160968	None	0	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
	9998202	69164	None	0	Rat	Binding	pKi	=	6.4	6.4	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL192485	69164	None	0	Rat	Binding	pKi	=	6.4	6.4	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	145961981	161529	None	0	Human	Binding	pKi	=	6.4	6.4	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4128497	161529	None	0	Human	Binding	pKi	=	6.4	6.4	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	4715419	188739	None	34	Human	Binding	pKi	=	5.4	5.4	4	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc(C2CCCN2)o1	10.1021/jm800145d
	CHEMBL505086	188739	None	34	Human	Binding	pKi	=	5.4	5.4	4	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc(C2CCCN2)o1	10.1021/jm800145d
	44392960	66299	None	0	Human	Binding	pKi	=	7.4	7.4	9	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL184843	66299	None	0	Human	Binding	pKi	=	7.4	7.4	9	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	15050959	204080	None	0	Rat	Binding	pKi	=	7.4	7.4	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	534	13	2	6	4.2	CC(=O)NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL70154	204080	None	0	Rat	Binding	pKi	=	7.4	7.4	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	534	13	2	6	4.2	CC(=O)NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	164627253	188601	None	0	Human	Binding	pKi	=	7.4	7.4	28	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4876651	188601	None	0	Human	Binding	pKi	=	7.4	7.4	28	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028989	188601	None	0	Human	Binding	pKi	=	7.4	7.4	28	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015390	178240	None	0	Human	Binding	pKi	=	7.4	7.4	-4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4648229	178240	None	0	Human	Binding	pKi	=	7.4	7.4	-4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650585	178240	None	0	Human	Binding	pKi	=	7.4	7.4	-4	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	14964494	11955	None	1	Rat	Binding	pKi	=	6.4	6.4	2	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118292	11955	None	1	Rat	Binding	pKi	=	6.4	6.4	2	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	14964494	11955	None	1	Rat	Binding	pKi	=	6.4	6.4	2	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118292	11955	None	1	Rat	Binding	pKi	=	6.4	6.4	2	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	14956867	204826	None	0	Rat	Binding	pKi	=	5.4	5.4	-4	2	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	228	1	0	4	0.6	CCN1C(=O)C2(CCN(C)CC2)OC1=S	10.1021/jm00068a005
	CHEMBL75380	204826	None	0	Rat	Binding	pKi	=	5.4	5.4	-4	2	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	228	1	0	4	0.6	CCN1C(=O)C2(CCN(C)CC2)OC1=S	10.1021/jm00068a005
	12739458	66549	None	0	Human	Binding	pKi	=	5.4	5.4	-2	3	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
	CHEMBL1824784	66549	None	0	Human	Binding	pKi	=	5.4	5.4	-2	3	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
	CHEMBL1852447	66549	None	0	Human	Binding	pKi	=	5.4	5.4	-2	3	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
	15086396	13290	None	0	Rat	Binding	pKi	=	6.4	6.4	-29	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1191773	13290	None	0	Rat	Binding	pKi	=	6.4	6.4	-29	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL542915	13290	None	0	Rat	Binding	pKi	=	6.4	6.4	-29	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
	49783209	17607	None	0	Human	Binding	pKi	=	6.4	6.4	-758	27	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	CHEMBL1258223	17607	None	0	Human	Binding	pKi	=	6.4	6.4	-758	27	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	164614364	188493	None	0	Human	Binding	pKi	=	5.4	5.4	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4847458	188493	None	0	Human	Binding	pKi	=	5.4	5.4	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028248	188493	None	0	Human	Binding	pKi	=	5.4	5.4	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44448380	11913	None	0	Human	Binding	pKi	=	5.4	5.4	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182644	11913	None	0	Human	Binding	pKi	=	5.4	5.4	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL257804	11913	None	0	Human	Binding	pKi	=	5.4	5.4	-1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	156011518	178336	None	0	Human	Binding	pKi	=	5.4	5.4	-6	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4637731	178336	None	0	Human	Binding	pKi	=	5.4	5.4	-6	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651208	178336	None	0	Human	Binding	pKi	=	5.4	5.4	-6	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	162353394	180768	None	0	Human	Binding	pKi	=	4.4	4.4	1	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	245	2	0	3	1.5	O=C(CN1CCCc2cnccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756237	180768	None	0	Human	Binding	pKi	=	4.4	4.4	1	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	245	2	0	3	1.5	O=C(CN1CCCc2cnccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	11828362	78918	None	0	Human	Binding	pKi	=	7.4	7.4	-57	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL2112959	78918	None	0	Human	Binding	pKi	=	7.4	7.4	-57	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	44431372	87313	None	0	Human	Binding	pKi	=	7.4	7.4	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
	CHEMBL233198	87313	None	0	Human	Binding	pKi	=	7.4	7.4	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
	21855	84244	None	42	Human	Binding	pKi	=	7.4	7.4	-7	6	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1016/s0960-894x(01)00186-x
	CHEMBL22108	84244	None	42	Human	Binding	pKi	=	7.4	7.4	-7	6	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1016/s0960-894x(01)00186-x
	DB08801	84244	None	42	Human	Binding	pKi	=	7.4	7.4	-7	6	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1016/s0960-894x(01)00186-x
	11834199	58769	None	0	Human	Binding	pKi	=	7.4	7.4	10	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCN(CC)CCC1=C(C(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL168704	58769	None	0	Human	Binding	pKi	=	7.4	7.4	10	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCN(CC)CCC1=C(C(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	10651844	115487	None	0	Rat	Binding	pKi	=	7.4	7.4	-4	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL335115	115487	None	0	Rat	Binding	pKi	=	7.4	7.4	-4	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	11695960	72393	None	0	Rat	Binding	pKi	=	6.4	6.4	-52	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	348	2	0	3	3.8	O=C(O[C@H]1CN2CCC1CC2)N1Cc2ccccc2C1c1ccccc1	10.1021/jm050099q
	CHEMBL198669	72393	None	0	Rat	Binding	pKi	=	6.4	6.4	-52	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	348	2	0	3	3.8	O=C(O[C@H]1CN2CCC1CC2)N1Cc2ccccc2C1c1ccccc1	10.1021/jm050099q
	10024068	131348	None	0	Rat	Binding	pKi	=	6.4	6.4	1	2	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	402	6	0	3	3.9	CC(C)N(CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O)C(C)C	10.1016/S0960-894X(97)00143-1
	CHEMBL368792	131348	None	0	Rat	Binding	pKi	=	6.4	6.4	1	2	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	402	6	0	3	3.9	CC(C)N(CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O)C(C)C	10.1016/S0960-894X(97)00143-1
	137630891	161127	None	0	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4085451	161127	None	0	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4117201	161127	None	0	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	10035281	100980	None	0	Human	Binding	pKi	=	5.4	5.4	-1	8	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	CHEMBL294273	100980	None	0	Human	Binding	pKi	=	5.4	5.4	-1	8	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	574989	204068	None	2	Rat	Binding	pKi	=	5.4	5.4	-	1	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranesThe compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes	ChEMBL	495	5	1	6	4.1	CN1CCN(CC(=O)N2c3cc(CO[Si](C)(C)C(C)(C)C)ccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL70082	204068	None	2	Rat	Binding	pKi	=	5.4	5.4	-	1	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranesThe compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes	ChEMBL	495	5	1	6	4.1	CN1CCN(CC(=O)N2c3cc(CO[Si](C)(C)C(C)(C)C)ccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	73353884	92320	None	0	Human	Binding	pKi	=	5.4	5.4	-3	8	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	295	3	1	3	2.7	c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2	10.1016/j.bmc.2013.07.045
	CHEMBL2429890	92320	None	0	Human	Binding	pKi	=	5.4	5.4	-3	8	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	295	3	1	3	2.7	c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2	10.1016/j.bmc.2013.07.045
	44378600	56525	None	0	Human	Binding	pKi	=	6.4	6.4	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	635	9	0	8	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1OC	10.1016/s0960-894x(02)00024-0
	CHEMBL163686	56525	None	0	Human	Binding	pKi	=	6.4	6.4	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	635	9	0	8	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1OC	10.1016/s0960-894x(02)00024-0
	15730	71116	None	80	Human	Binding	pKi	=	5.4	5.4	-2	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
	CHEMBL195437	71116	None	80	Human	Binding	pKi	=	5.4	5.4	-2	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
	164616776	188514	None	0	Human	Binding	pKi	=	5.4	5.4	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL4852133	188514	None	0	Human	Binding	pKi	=	5.4	5.4	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL5028394	188514	None	0	Human	Binding	pKi	=	5.4	5.4	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	3652	4095	None	79	Human	Binding	pKi	=	5.4	5.4	-18	18	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	57	4095	None	79	Human	Binding	pKi	=	5.4	5.4	-18	18	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	60809	4095	None	79	Human	Binding	pKi	=	5.4	5.4	-18	18	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	5.4	5.4	-18	18	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	DB15357	4095	None	79	Human	Binding	pKi	=	5.4	5.4	-18	18	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	44392967	65605	None	0	Human	Binding	pKi	=	6.4	6.4	1	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	4	0	3	5.0	CCN1C(CCC2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@H]23)CCC1(C)C	10.1016/j.bmcl.2004.05.047
	CHEMBL183331	65605	None	0	Human	Binding	pKi	=	6.4	6.4	1	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	4	0	3	5.0	CCN1C(CCC2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@H]23)CCC1(C)C	10.1016/j.bmcl.2004.05.047
	164620290	188541	None	0	Human	Binding	pKi	=	7.3	7.3	5	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4870729	188541	None	0	Human	Binding	pKi	=	7.3	7.3	5	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028589	188541	None	0	Human	Binding	pKi	=	7.3	7.3	5	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164621861	188555	None	0	Human	Binding	pKi	=	7.3	7.3	16	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4868124	188555	None	0	Human	Binding	pKi	=	7.3	7.3	16	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028673	188555	None	0	Human	Binding	pKi	=	7.3	7.3	16	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	14964511	12099	None	0	Rat	Binding	pKi	=	6.4	6.4	-	1	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL1183954	12099	None	0	Rat	Binding	pKi	=	6.4	6.4	-	1	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL325473	12099	None	0	Rat	Binding	pKi	=	6.4	6.4	-	1	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	16086060	168941	None	0	Human	Binding	pKi	=	6.4	6.4	-1148	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL438822	168941	None	0	Human	Binding	pKi	=	6.4	6.4	-1148	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	70693619	73141	None	0	Human	Binding	pKi	=	4.4	4.4	-	1	Negative allosteric modulation at M2 receptor by AS-MS analysisNegative allosteric modulation at M2 receptor by AS-MS analysis	ChEMBL	388	10	2	3	4.7	CC[C@@H](NCc1cccc(C(=O)NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmc.2011.11.071
	CHEMBL2011502	73141	None	0	Human	Binding	pKi	=	4.4	4.4	-	1	Negative allosteric modulation at M2 receptor by AS-MS analysisNegative allosteric modulation at M2 receptor by AS-MS analysis	ChEMBL	388	10	2	3	4.7	CC[C@@H](NCc1cccc(C(=O)NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmc.2011.11.071
	483747	105407	None	3	Human	Binding	pKi	=	6.3	6.3	-177	4	Inhibition of binding affinity to muscarinic receptor M2Inhibition of binding affinity to muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL311795	105407	None	3	Human	Binding	pKi	=	6.3	6.3	-177	4	Inhibition of binding affinity to muscarinic receptor M2Inhibition of binding affinity to muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	10139614	5029	None	0	Human	Binding	pKi	=	5.3	5.3	-323	4	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	462	8	1	5	5.9	CCCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL105160	5029	None	0	Human	Binding	pKi	=	5.3	5.3	-323	4	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	462	8	1	5	5.9	CCCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	441383	20331	None	57	Human	Binding	pKi	=	5.3	5.3	-7	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	CHEMBL1306	20331	None	57	Human	Binding	pKi	=	5.3	5.3	-7	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	135398737	957	None	93	Rat	Binding	pKi	=	7.3	7.3	-6	91	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	38	957	None	93	Rat	Binding	pKi	=	7.3	7.3	-6	91	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	722	957	None	93	Rat	Binding	pKi	=	7.3	7.3	-6	91	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	CHEMBL42	957	None	93	Rat	Binding	pKi	=	7.3	7.3	-6	91	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	DB00363	957	None	93	Rat	Binding	pKi	=	7.3	7.3	-6	91	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	155552923	176305	None	0	Human	Binding	pKi	=	7.3	7.3	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4544820	176305	None	0	Human	Binding	pKi	=	7.3	7.3	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595245	176305	None	0	Human	Binding	pKi	=	7.3	7.3	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	44379080	58163	None	0	Human	Binding	pKi	=	7.3	7.3	1	3	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	678	10	0	5	7.5	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)N(C(=O)c3ccc(F)cc3)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
	CHEMBL168149	58163	None	0	Human	Binding	pKi	=	7.3	7.3	1	3	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	678	10	0	5	7.5	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)N(C(=O)c3ccc(F)cc3)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
	3072504	5810	None	7	Mouse	Binding	pKi	=	6.3	6.3	-	1	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL107892	5810	None	7	Mouse	Binding	pKi	=	6.3	6.3	-	1	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	10429011	36126	None	0	Human	Binding	pKi	=	6.3	6.3	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	240	1	0	1	3.6	C[N+]12C=C(c3cc4ccccc4o3)C(CC1)CC2	10.1021/jm00003a011
	CHEMBL144435	36126	None	0	Human	Binding	pKi	=	6.3	6.3	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	240	1	0	1	3.6	C[N+]12C=C(c3cc4ccccc4o3)C(CC1)CC2	10.1021/jm00003a011
	9910802	121008	None	0	Human	Binding	pKi	=	6.3	6.3	-141	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	4	4.2	O=C(NC1CCN(Cc2ccsc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL356505	121008	None	0	Human	Binding	pKi	=	6.3	6.3	-141	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	4	4.2	O=C(NC1CCN(Cc2ccsc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	44312132	102300	None	0	Human	Binding	pKi	=	5.3	5.3	1	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	406	5	0	4	4.4	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL303443	102300	None	0	Human	Binding	pKi	=	5.3	5.3	1	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	406	5	0	4	4.4	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00438-8
	10572657	40537	None	0	Human	Binding	pKi	=	5.3	5.3	-45	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2cccnc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL148328	40537	None	0	Human	Binding	pKi	=	5.3	5.3	-45	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2cccnc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	137639541	156701	None	0	Human	Binding	pKi	=	4.3	4.3	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4070061	156701	None	0	Human	Binding	pKi	=	4.3	4.3	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	9906447	195575	None	2	Human	Binding	pKi	=	6.3	6.3	-645	13	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	CHEMBL2031738	195575	None	2	Human	Binding	pKi	=	6.3	6.3	-645	13	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	CHEMBL555146	195575	None	2	Human	Binding	pKi	=	6.3	6.3	-645	13	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	1273	1752	None	16	Human	Binding	pKi	=	6.3	6.3	-1	3	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	3450	1752	None	16	Human	Binding	pKi	=	6.3	6.3	-1	3	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	356	1752	None	16	Human	Binding	pKi	=	6.3	6.3	-1	3	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	6172	1752	None	16	Human	Binding	pKi	=	6.3	6.3	-1	3	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	67425	1752	None	16	Human	Binding	pKi	=	6.3	6.3	-1	3	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	CHEMBL360055	1752	None	16	Human	Binding	pKi	=	6.3	6.3	-1	3	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	DB00483	1752	None	16	Human	Binding	pKi	=	6.3	6.3	-1	3	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	2719	916	None	74	Human	Binding	pKi	=	5.3	5.3	-4	11	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
	5535	916	None	74	Human	Binding	pKi	=	5.3	5.3	-4	11	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
	607	916	None	74	Human	Binding	pKi	=	5.3	5.3	-4	11	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
	CHEMBL76	916	None	74	Human	Binding	pKi	=	5.3	5.3	-4	11	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
	DB00608	916	None	74	Human	Binding	pKi	=	5.3	5.3	-4	11	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
	46227487	14125	None	0	Human	Binding	pKi	=	4.3	4.3	-1	4	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL1198047	14125	None	0	Human	Binding	pKi	=	4.3	4.3	-1	4	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL593861	14125	None	0	Human	Binding	pKi	=	4.3	4.3	-1	4	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	319	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	321	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	444031	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	784	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	CHEMBL1346	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	DB00496	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	3042	1413	None	35	Rat	Binding	pKi	=	7.3	7.3	-12	15	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
	355	1413	None	35	Rat	Binding	pKi	=	7.3	7.3	-12	15	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
	868	1413	None	35	Rat	Binding	pKi	=	7.3	7.3	-12	15	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
	CHEMBL1123	1413	None	35	Rat	Binding	pKi	=	7.3	7.3	-12	15	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
	DB00804	1413	None	35	Rat	Binding	pKi	=	7.3	7.3	-12	15	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
	16125585	84750	None	0	Human	Binding	pKi	=	7.3	7.3	-7	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.4	C[N+]1(CCOCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222976	84750	None	0	Human	Binding	pKi	=	7.3	7.3	-7	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.4	C[N+]1(CCOCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	73352330	92183	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2424680	92183	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	118710666	120827	None	0	Human	Binding	pKi	=	7.3	7.3	-4	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323282	120827	None	0	Human	Binding	pKi	=	7.3	7.3	-4	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558210	120827	None	0	Human	Binding	pKi	=	7.3	7.3	-4	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	16125619	84721	None	0	Human	Binding	pKi	=	7.3	7.3	-6	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	427	5	2	3	4.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(O)c2)CC1	10.1021/jm061159a
	CHEMBL222804	84721	None	0	Human	Binding	pKi	=	7.3	7.3	-6	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	427	5	2	3	4.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(O)c2)CC1	10.1021/jm061159a
	14964506	113314	None	1	Rat	Binding	pKi	=	5.3	5.3	-6	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL331556	113314	None	1	Rat	Binding	pKi	=	5.3	5.3	-6	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	66561966	74701	None	0	Human	Binding	pKi	=	5.3	5.3	-1	4	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	193	2	0	1	3.2	C1CCC(CN2C3CCC2CC3)CC1	10.1016/j.bmcl.2012.04.077
	CHEMBL2030625	74701	None	0	Human	Binding	pKi	=	5.3	5.3	-1	4	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	193	2	0	1	3.2	C1CCC(CN2C3CCC2CC3)CC1	10.1016/j.bmcl.2012.04.077
	44437308	12325	None	0	Human	Binding	pKi	=	6.3	6.3	1	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
	CHEMBL1185188	12325	None	0	Human	Binding	pKi	=	6.3	6.3	1	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
	CHEMBL396845	12325	None	0	Human	Binding	pKi	=	6.3	6.3	1	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
	73350931	92532	None	0	Human	Binding	pKi	=	6.3	6.3	2	5	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	279	3	0	2	2.4	CN(Cc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432040	92532	None	0	Human	Binding	pKi	=	6.3	6.3	2	5	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	279	3	0	2	2.4	CN(Cc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	118719930	115782	None	0	Human	Binding	pKi	=	6.3	6.3	-5	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	470	17	1	3	6.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCCCO)CC1	10.1021/jm501173q
	CHEMBL3354077	115782	None	0	Human	Binding	pKi	=	6.3	6.3	-5	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	470	17	1	3	6.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCCCO)CC1	10.1021/jm501173q
	10474335	194690	None	23	Human	Binding	pKi	=	5.3	5.3	-165	10	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
	CHEMBL53325	194690	None	23	Human	Binding	pKi	=	5.3	5.3	-165	10	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
	162658421	181099	None	0	Human	Binding	pKi	=	5.3	5.3	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4760150	181099	None	0	Human	Binding	pKi	=	5.3	5.3	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	137644962	158491	None	0	Human	Binding	pKi	=	5.3	5.3	-239	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	363	6	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4091058	158491	None	0	Human	Binding	pKi	=	5.3	5.3	-239	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	363	6	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	44448457	11911	None	0	Human	Binding	pKi	=	4.3	4.3	-4	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182638	11911	None	0	Human	Binding	pKi	=	4.3	4.3	-4	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL257586	11911	None	0	Human	Binding	pKi	=	4.3	4.3	-4	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	24894515	176868	None	4	Human	Binding	pKi	=	4.3	4.3	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@@H]1c1ccco1	10.1021/jm800145d
	CHEMBL461502	176868	None	4	Human	Binding	pKi	=	4.3	4.3	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@@H]1c1ccco1	10.1021/jm800145d
	44267709	16640	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	5	6.4	CC(C)OC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12419	16640	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	5	6.4	CC(C)OC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44431369	87981	None	0	Human	Binding	pKi	=	7.3	7.3	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
	CHEMBL234253	87981	None	0	Human	Binding	pKi	=	7.3	7.3	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
	324	1923	None	15	Human	Binding	pKi	=	7.3	7.3	-1	9	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
	6436265	1923	None	15	Human	Binding	pKi	=	7.3	7.3	-1	9	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
	CHEMBL277642	1923	None	15	Human	Binding	pKi	=	7.3	7.3	-1	9	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
	3929516	107368	None	4	Rat	Binding	pKi	=	7.3	7.3	-5	4	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	343	4	0	2	4.7	CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
	CHEMBL317757	107368	None	4	Rat	Binding	pKi	=	7.3	7.3	-5	4	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	343	4	0	2	4.7	CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
	11610557	72029	None	0	Rat	Binding	pKi	=	6.3	6.3	-85	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
	CHEMBL197588	72029	None	0	Rat	Binding	pKi	=	6.3	6.3	-85	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
	10551354	39755	None	0	Human	Binding	pKi	=	6.3	6.3	-190	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	446	6	2	3	4.2	O=C(NC1CCN(Cc2cccc(F)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL147611	39755	None	0	Human	Binding	pKi	=	6.3	6.3	-190	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	446	6	2	3	4.2	O=C(NC1CCN(Cc2cccc(F)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	44304818	203304	None	0	Rat	Binding	pKi	=	6.3	6.3	-1	7	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64788	203304	None	0	Rat	Binding	pKi	=	6.3	6.3	-1	7	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
	44304818	203304	None	0	Human	Binding	pKi	=	6.3	6.3	-1	7	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64788	203304	None	0	Human	Binding	pKi	=	6.3	6.3	-1	7	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
	137629673	161157	None	0	Human	Binding	pKi	=	5.3	5.3	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4094819	161157	None	0	Human	Binding	pKi	=	5.3	5.3	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117396	161157	None	0	Human	Binding	pKi	=	5.3	5.3	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
	456293	204056	None	1	Human	Binding	pKi	=	6.3	6.3	-17	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL70010	204056	None	1	Human	Binding	pKi	=	6.3	6.3	-17	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	44383489	128471	None	0	Human	Binding	pKi	=	6.3	6.3	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	434	4	0	5	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C(=O)OC(C)(C)C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL366640	128471	None	0	Human	Binding	pKi	=	6.3	6.3	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	434	4	0	5	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C(=O)OC(C)(C)C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	73346336	92543	None	0	Human	Binding	pKi	=	6.3	6.3	1	6	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	5	0	2	3.0	CN(CCCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432054	92543	None	0	Human	Binding	pKi	=	6.3	6.3	1	6	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	5	0	2	3.0	CN(CCCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	9308	17752	None	21	Human	Binding	pKi	=	6.3	6.3	2	7	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
	CHEMBL1255785	17752	None	21	Human	Binding	pKi	=	6.3	6.3	2	7	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
	CHEMBL12587	17752	None	21	Human	Binding	pKi	=	6.3	6.3	2	7	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
	CHEMBL292911	17752	None	21	Human	Binding	pKi	=	6.3	6.3	2	7	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
	11809446	59677	None	0	Human	Binding	pKi	=	5.3	5.3	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL172234	59677	None	0	Human	Binding	pKi	=	5.3	5.3	1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	44422692	11851	None	0	Human	Binding	pKi	=	5.3	5.3	5	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL1182296	11851	None	0	Human	Binding	pKi	=	5.3	5.3	5	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL228144	11851	None	0	Human	Binding	pKi	=	5.3	5.3	5	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	44446841	12336	None	0	Human	Binding	pKi	=	5.3	5.3	2	4	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL1185281	12336	None	0	Human	Binding	pKi	=	5.3	5.3	2	4	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL404557	12336	None	0	Human	Binding	pKi	=	5.3	5.3	2	4	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	162657652	180983	None	0	Human	Binding	pKi	=	4.3	4.3	-1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758742	180983	None	0	Human	Binding	pKi	=	4.3	4.3	-1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	44431375	87314	None	0	Human	Binding	pKi	=	7.3	7.3	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL233199	87314	None	0	Human	Binding	pKi	=	7.3	7.3	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	44431370	87982	None	0	Human	Binding	pKi	=	7.3	7.3	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234254	87982	None	0	Human	Binding	pKi	=	7.3	7.3	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	9308	17752	None	21	Rat	Binding	pKi	=	6.3	6.3	-2	7	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
	CHEMBL1255785	17752	None	21	Rat	Binding	pKi	=	6.3	6.3	-2	7	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
	CHEMBL12587	17752	None	21	Rat	Binding	pKi	=	6.3	6.3	-2	7	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
	CHEMBL292911	17752	None	21	Rat	Binding	pKi	=	6.3	6.3	-2	7	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
	16086059	80773	None	0	Human	Binding	pKi	=	6.3	6.3	-2187	7	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm301774u
	CHEMBL215180	80773	None	0	Human	Binding	pKi	=	6.3	6.3	-2187	7	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm301774u
	16125618	168675	None	0	Human	Binding	pKi	=	6.3	6.3	-19	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1ccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)cc1	10.1021/jm061159a
	CHEMBL436492	168675	None	0	Human	Binding	pKi	=	6.3	6.3	-19	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1ccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)cc1	10.1021/jm061159a
	16086059	80773	None	0	Human	Binding	pKi	=	6.3	6.3	-2187	7	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL215180	80773	None	0	Human	Binding	pKi	=	6.3	6.3	-2187	7	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	9821459	200441	None	11	Human	Binding	pKi	=	6.3	6.3	-117	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	7	2	3	4.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
	CHEMBL59836	200441	None	11	Human	Binding	pKi	=	6.3	6.3	-117	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	7	2	3	4.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
	15105207	169193	None	1	Human	Binding	pKi	=	5.3	5.3	-	1	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	10	1	3	3.0	CCN(CC)CCOCCNC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL440686	169193	None	1	Human	Binding	pKi	=	5.3	5.3	-	1	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	10	1	3	3.0	CCN(CC)CCOCCNC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
	14537191	147987	None	0	Rat	Binding	pKi	=	5.3	5.3	-2	2	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL39342	147987	None	0	Rat	Binding	pKi	=	5.3	5.3	-2	2	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	474465	203069	None	2	Human	Binding	pKi	=	6.3	6.3	-1	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	525	6	0	5	5.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(Cc4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL63757	203069	None	2	Human	Binding	pKi	=	6.3	6.3	-1	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	525	6	0	5	5.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(Cc4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	44420791	84702	None	0	Human	Binding	pKi	=	6.3	6.3	-3	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	376	3	1	1	3.7	C[N+]1(C)C2CCC1CC(N1CC(c3ccccc3)(c3ccccc3)NC1=O)C2	10.1021/jm061160+
	CHEMBL222689	84702	None	0	Human	Binding	pKi	=	6.3	6.3	-3	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	376	3	1	1	3.7	C[N+]1(C)C2CCC1CC(N1CC(c3ccccc3)(c3ccccc3)NC1=O)C2	10.1021/jm061160+
	44325013	207192	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
	CHEMBL92569	207192	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
	44295954	162893	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc5[nH]ccc5c4)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL417369	162893	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc5[nH]ccc5c4)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44295712	189507	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5c(F)cc(F)cc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL51400	189507	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5c(F)cc(F)cc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44406521	73904	None	0	Human	Binding	pKi	=	8.3	8.3	-4	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL201933	73904	None	0	Human	Binding	pKi	=	8.3	8.3	-4	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10199963	141313	None	0	Human	Binding	pKi	=	8.3	8.3	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2cccc(F)c2)c2cccc(F)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL383389	141313	None	0	Human	Binding	pKi	=	8.3	8.3	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2cccc(F)c2)c2cccc(F)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10299489	204139	None	0	Human	Binding	pKi	=	8.3	8.3	4	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	480	6	0	4	5.4	COc1ccc([S+]([O-])c2ccc(C(N3CCN(C4CCCCC4)CC3)C(F)(F)F)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL70464	204139	None	0	Human	Binding	pKi	=	8.3	8.3	4	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	480	6	0	4	5.4	COc1ccc([S+]([O-])c2ccc(C(N3CCN(C4CCCCC4)CC3)C(F)(F)F)cc2)cc1	10.1016/s0960-894x(00)00438-8
	129989	451	None	51	Rat	Binding	pKi	=	8.3	8.3	1	9	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	8584	451	None	51	Rat	Binding	pKi	=	8.3	8.3	1	9	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	CHEMBL43383	451	None	51	Rat	Binding	pKi	=	8.3	8.3	1	9	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	129989	451	None	51	Human	Binding	pKi	=	8.3	8.3	-1	9	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	8584	451	None	51	Human	Binding	pKi	=	8.3	8.3	-1	9	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	CHEMBL43383	451	None	51	Human	Binding	pKi	=	8.3	8.3	-1	9	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	154417	93258	None	60	Human	Binding	pKi	=	8.3	8.3	-18	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL1331216	93258	None	60	Human	Binding	pKi	=	8.3	8.3	-18	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL2449003	93258	None	60	Human	Binding	pKi	=	8.3	8.3	-18	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	DB00424	93258	None	60	Human	Binding	pKi	=	8.3	8.3	-18	9	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	10049361	206119	None	0	Human	Binding	pKi	=	8.3	8.3	-10	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85892	206119	None	0	Human	Binding	pKi	=	8.3	8.3	-10	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44325013	207192	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL92569	207192	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	44431391	146419	None	0	Human	Binding	pKi	=	8.3	8.3	-1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL392186	146419	None	0	Human	Binding	pKi	=	8.3	8.3	-1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	10.1016/j.bmcl.2006.11.058
	118710662	120828	None	0	Human	Binding	pKi	=	8.3	8.3	1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323280	120828	None	0	Human	Binding	pKi	=	8.3	8.3	1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558229	120828	None	0	Human	Binding	pKi	=	8.3	8.3	1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	119357	304	None	49	Human	Binding	pKi	=	8.3	8.3	1	6	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
	3264	304	None	49	Human	Binding	pKi	=	8.3	8.3	1	6	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
	368	304	None	49	Human	Binding	pKi	=	8.3	8.3	1	6	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
	CHEMBL279453	304	None	49	Human	Binding	pKi	=	8.3	8.3	1	6	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
	118710662	120828	None	0	Human	Binding	pKi	=	8.3	8.3	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323280	120828	None	0	Human	Binding	pKi	=	8.3	8.3	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558229	120828	None	0	Human	Binding	pKi	=	8.3	8.3	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	155548586	176595	None	0	Human	Binding	pKi	=	8.3	8.3	10	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4537517	176595	None	0	Human	Binding	pKi	=	8.3	8.3	10	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597611	176595	None	0	Human	Binding	pKi	=	8.3	8.3	10	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	70683405	74473	None	0	Human	Binding	pKi	=	8.3	8.3	3	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2021477	74473	None	0	Human	Binding	pKi	=	8.3	8.3	3	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2027984	74473	None	0	Human	Binding	pKi	=	8.3	8.3	3	4	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	315401	89810	None	4	Human	Binding	pKi	=	8.3	8.3	-4	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	343	8	1	4	3.5	CCN(CC)CCSC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL2377387	89810	None	4	Human	Binding	pKi	=	8.3	8.3	-4	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	343	8	1	4	3.5	CCN(CC)CCSC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	44420795	11848	None	0	Human	Binding	pKi	=	8.3	8.3	-7	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL1182222	11848	None	0	Human	Binding	pKi	=	8.3	8.3	-7	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL223055	11848	None	0	Human	Binding	pKi	=	8.3	8.3	-7	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	14537188	136544	None	0	Rat	Binding	pKi	=	8.3	8.3	-1	5	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL37372	136544	None	0	Rat	Binding	pKi	=	8.3	8.3	-1	5	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	10770914	25059	None	0	Rat	Binding	pKi	=	8.3	8.3	-19	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL134692	25059	None	0	Rat	Binding	pKi	=	8.3	8.3	-19	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	42596929	77186	None	0	Human	Binding	pKi	=	8.2	8.2	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042404	77186	None	0	Human	Binding	pKi	=	8.2	8.2	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2079021	77186	None	0	Human	Binding	pKi	=	8.2	8.2	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	688567	63032	None	4	Rat	Binding	pKi	=	8.2	8.2	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	CHEMBL1788199	63032	None	4	Rat	Binding	pKi	=	8.2	8.2	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	425249	89795	None	8	Human	Binding	pKi	=	8.2	8.2	10	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.6	CC(C)N(CCOC(=O)C(O)(c1ccccc1)c1ccccc1)C(C)C	10.1016/j.bmc.2013.01.072
	CHEMBL2377261	89795	None	8	Human	Binding	pKi	=	8.2	8.2	10	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.6	CC(C)N(CCOC(=O)C(O)(c1ccccc1)c1ccccc1)C(C)C	10.1016/j.bmc.2013.01.072
	CHEMBL5277670	193941	None	0	Human	Binding	pKi	=	8.2	8.2	-2	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	930	19	2	5	13.0	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
	319	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	321	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	444031	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	784	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	CHEMBL1346	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	DB00496	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	44406406	133535	None	0	Human	Binding	pKi	=	7.3	7.3	-12	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	340	3	1	4	2.6	COC1(C#CC(O)(c2ccccn2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL370862	133535	None	0	Human	Binding	pKi	=	7.3	7.3	-12	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	340	3	1	4	2.6	COC1(C#CC(O)(c2ccccn2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406520	135256	None	0	Human	Binding	pKi	=	7.3	7.3	-3	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL372566	135256	None	0	Human	Binding	pKi	=	7.3	7.3	-3	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406395	140278	None	0	Human	Binding	pKi	=	7.3	7.3	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2cccc(C)c2)c2cccc(C)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL380583	140278	None	0	Human	Binding	pKi	=	7.3	7.3	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2cccc(C)c2)c2cccc(C)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	24809738	11887	None	0	Human	Binding	pKi	=	7.3	7.3	13	4	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
	CHEMBL1182466	11887	None	0	Human	Binding	pKi	=	7.3	7.3	13	4	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
	CHEMBL239655	11887	None	0	Human	Binding	pKi	=	7.3	7.3	13	4	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
	15050958	203794	None	0	Rat	Binding	pKi	=	7.3	7.3	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	520	12	2	6	3.8	CC(=O)NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL68292	203794	None	0	Rat	Binding	pKi	=	7.3	7.3	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	520	12	2	6	3.8	CC(=O)NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	3652	4095	None	79	Human	Binding	pKi	=	7.3	7.3	-18	18	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	57	4095	None	79	Human	Binding	pKi	=	7.3	7.3	-18	18	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	60809	4095	None	79	Human	Binding	pKi	=	7.3	7.3	-18	18	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	7.3	7.3	-18	18	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	DB15357	4095	None	79	Human	Binding	pKi	=	7.3	7.3	-18	18	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	118710668	120832	None	0	Human	Binding	pKi	=	7.3	7.3	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3323283	120832	None	0	Human	Binding	pKi	=	7.3	7.3	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3558234	120832	None	0	Human	Binding	pKi	=	7.3	7.3	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	44319043	206057	None	0	Human	Binding	pKi	=	7.3	7.3	-17	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85391	206057	None	0	Human	Binding	pKi	=	7.3	7.3	-17	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	3652	4095	None	79	Human	Binding	pKi	=	7.3	7.3	-18	18	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
	57	4095	None	79	Human	Binding	pKi	=	7.3	7.3	-18	18	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
	60809	4095	None	79	Human	Binding	pKi	=	7.3	7.3	-18	18	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	7.3	7.3	-18	18	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
	DB15357	4095	None	79	Human	Binding	pKi	=	7.3	7.3	-18	18	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
	5387	94877	None	31	Rat	Binding	pKi	=	7.3	7.3	-19	6	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	10.1021/jm00111a032
	CHEMBL253978	94877	None	31	Rat	Binding	pKi	=	7.3	7.3	-19	6	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	10.1021/jm00111a032
	44313489	204628	None	0	Human	Binding	pKi	=	6.3	6.3	1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	400	9	1	3	4.6	CCN(CC)CCOCNC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	CHEMBL73501	204628	None	0	Human	Binding	pKi	=	6.3	6.3	1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	400	9	1	3	4.6	CCN(CC)CCOCNC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	2551	793	None	23	Rat	Binding	pKi	=	5.3	5.3	-3	11	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	298	793	None	23	Rat	Binding	pKi	=	5.3	5.3	-3	11	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	488	793	None	23	Rat	Binding	pKi	=	5.3	5.3	-3	11	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL965	793	None	23	Rat	Binding	pKi	=	5.3	5.3	-3	11	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	DB00411	793	None	23	Rat	Binding	pKi	=	5.3	5.3	-3	11	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	15196235	119191	None	2	Human	Binding	pKi	=	5.3	5.3	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	181	1	0	2	1.5	C1COC(C2CN3CCC2CC3)C1	10.1021/jm00003a011
	CHEMBL343182	119191	None	2	Human	Binding	pKi	=	5.3	5.3	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	181	1	0	2	1.5	C1COC(C2CN3CCC2CC3)C1	10.1021/jm00003a011
	15749864	100461	None	3	Human	Binding	pKi	=	4.3	4.3	-2	2	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	169	0	0	3	0.5	C1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	CHEMBL290715	100461	None	3	Human	Binding	pKi	=	4.3	4.3	-2	2	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	169	0	0	3	0.5	C1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	137629259	161002	None	0	Human	Binding	pKi	=	4.3	4.3	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4092769	161002	None	0	Human	Binding	pKi	=	4.3	4.3	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116203	161002	None	0	Human	Binding	pKi	=	4.3	4.3	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44406387	72841	None	0	Human	Binding	pKi	=	6.3	6.3	-5	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2ccc(C)cc2)c2ccc(C)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200209	72841	None	0	Human	Binding	pKi	=	6.3	6.3	-5	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2ccc(C)cc2)c2ccc(C)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	2247	505	None	81	Human	Binding	pKi	=	6.3	6.3	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	505	None	81	Human	Binding	pKi	=	6.3	6.3	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	505	None	81	Human	Binding	pKi	=	6.3	6.3	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	505	None	81	Human	Binding	pKi	=	6.3	6.3	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	505	None	81	Human	Binding	pKi	=	6.3	6.3	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	71455896	83803	None	0	Human	Binding	pKi	=	5.3	5.3	-1	5	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	266	2	1	3	1.3	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccn1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205832	83803	None	0	Human	Binding	pKi	=	5.3	5.3	-1	5	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	266	2	1	3	1.3	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccn1	10.1016/j.bmcl.2012.08.046
	11819782	95884	None	0	Human	Binding	pKi	=	5.3	5.3	10	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL259131	95884	None	0	Human	Binding	pKi	=	5.3	5.3	10	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
	6604789	101045	None	5	Human	Binding	pKi	=	4.3	4.3	-199	10	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
	CHEMBL294649	101045	None	5	Human	Binding	pKi	=	4.3	4.3	-199	10	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
	10337773	101583	None	0	Human	Binding	pKi	=	4.3	4.3	-125	10	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
	CHEMBL298612	101583	None	0	Human	Binding	pKi	=	4.3	4.3	-125	10	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
	162670602	182935	None	0	Human	Binding	pKi	=	4.3	4.3	1	2	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4792675	182935	None	0	Human	Binding	pKi	=	4.3	4.3	1	2	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	4735	195113	None	96	Human	Binding	pKi	=	6.3	6.3	-9	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	CHEMBL361506	195113	None	96	Human	Binding	pKi	=	6.3	6.3	-9	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	CHEMBL55	195113	None	96	Human	Binding	pKi	=	6.3	6.3	-9	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	11057	176147	None	23	Human	Binding	pKi	=	6.3	6.3	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	3468	176147	None	23	Human	Binding	pKi	=	6.3	6.3	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL459265	176147	None	23	Human	Binding	pKi	=	6.3	6.3	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL64894	176147	None	23	Human	Binding	pKi	=	6.3	6.3	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	44344077	10448	None	0	Rat	Binding	pKi	=	7.3	7.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	616	7	0	6	6.2	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL116404	10448	None	0	Rat	Binding	pKi	=	7.3	7.3	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	616	7	0	6	6.2	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	9974229	120284	None	0	Human	Binding	pKi	=	7.3	7.3	4	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	335	4	0	4	3.1	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCOCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL352618	120284	None	0	Human	Binding	pKi	=	7.3	7.3	4	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	335	4	0	4	3.1	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCOCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	11808947	59451	None	0	Human	Binding	pKi	=	7.3	7.3	4	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	CC(C1=C(CN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL171216	59451	None	0	Human	Binding	pKi	=	7.3	7.3	4	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	CC(C1=C(CN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	10203251	5222	None	0	Human	Binding	pKi	=	6.3	6.3	-257	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	5	0	6	4.8	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(OC)cc2CCN1C3	10.1021/jm011116o
	CHEMBL106224	5222	None	0	Human	Binding	pKi	=	6.3	6.3	-257	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	5	0	6	4.8	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(OC)cc2CCN1C3	10.1021/jm011116o
	11004046	5452	None	0	Human	Binding	pKi	=	6.3	6.3	-33	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	3	0	6	4.1	CCOC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL107444	5452	None	0	Human	Binding	pKi	=	6.3	6.3	-33	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	3	0	6	4.1	CCOC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	15678856	103779	None	0	Rat	Binding	pKi	=	5.3	5.3	-1	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	394	5	2	6	1.3	NCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL308893	103779	None	0	Rat	Binding	pKi	=	5.3	5.3	-1	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	394	5	2	6	1.3	NCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	3652	46242	None	70	Human	Binding	pKi	=	5.3	5.3	-2	9	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
	CHEMBL1535	46242	None	70	Human	Binding	pKi	=	5.3	5.3	-2	9	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
	162353388	180977	None	0	Human	Binding	pKi	=	5.3	5.3	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4758633	180977	None	0	Human	Binding	pKi	=	5.3	5.3	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	162353384	181088	None	0	Human	Binding	pKi	=	5.3	5.3	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4760037	181088	None	0	Human	Binding	pKi	=	5.3	5.3	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	11515739	78330	None	0	Human	Binding	pKi	=	4.3	4.3	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL2092736	78330	None	0	Human	Binding	pKi	=	4.3	4.3	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL2109804	78330	None	0	Human	Binding	pKi	=	4.3	4.3	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	16124705	84627	None	0	Human	Binding	pKi	=	6.3	6.3	-77	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	451	5	1	2	5.8	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	CHEMBL222207	84627	None	0	Human	Binding	pKi	=	6.3	6.3	-77	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	451	5	1	2	5.8	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	2812	4777	None	101	Human	Binding	pKi	=	5.3	5.3	-33	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	CHEMBL104	4777	None	101	Human	Binding	pKi	=	5.3	5.3	-33	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	107867	2972	None	55	Human	Binding	pKi	=	7.3	7.3	2	11	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
	309	2972	None	55	Human	Binding	pKi	=	7.3	7.3	2	11	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
	CHEMBL17045	2972	None	55	Human	Binding	pKi	=	7.3	7.3	2	11	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
	137645406	157900	None	0	Human	Binding	pKi	=	7.3	7.3	-6	13	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
	CHEMBL4084262	157900	None	0	Human	Binding	pKi	=	7.3	7.3	-6	13	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
	164628906	188614	None	0	Human	Binding	pKi	=	7.3	7.3	10	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4877107	188614	None	0	Human	Binding	pKi	=	7.3	7.3	10	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5029079	188614	None	0	Human	Binding	pKi	=	7.3	7.3	10	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44382974	59511	None	0	Human	Binding	pKi	=	6.3	6.3	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL171520	59511	None	0	Human	Binding	pKi	=	6.3	6.3	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	16124708	137334	None	0	Human	Binding	pKi	=	6.3	6.3	-28	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	0	2	5.0	CN1C(=O)N(C2CCN(Cc3ccccc3)CC2)CC1(c1ccccc1)c1ccccc1	10.1021/jm061159a
	CHEMBL375277	137334	None	0	Human	Binding	pKi	=	6.3	6.3	-28	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	0	2	5.0	CN1C(=O)N(C2CCN(Cc3ccccc3)CC2)CC1(c1ccccc1)c1ccccc1	10.1021/jm061159a
	14964513	11417	None	0	Rat	Binding	pKi	=	4.3	4.3	-	1	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL1180268	11417	None	0	Rat	Binding	pKi	=	4.3	4.3	-	1	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL119508	11417	None	0	Rat	Binding	pKi	=	4.3	4.3	-	1	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	2200	3129	None	46	Human	Binding	pKi	=	6.3	6.3	-35	13	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
	328	3129	None	46	Human	Binding	pKi	=	6.3	6.3	-35	13	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
	4848	3129	None	46	Human	Binding	pKi	=	6.3	6.3	-35	13	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.3	6.3	-35	13	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
	DB00670	3129	None	46	Human	Binding	pKi	=	6.3	6.3	-35	13	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
	44450620	95829	None	0	Human	Binding	pKi	=	5.3	5.3	3	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	CHEMBL258905	95829	None	0	Human	Binding	pKi	=	5.3	5.3	3	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	44422697	11850	None	0	Human	Binding	pKi	=	5.3	5.3	4	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL1182277	11850	None	0	Human	Binding	pKi	=	5.3	5.3	4	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL227429	11850	None	0	Human	Binding	pKi	=	5.3	5.3	4	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	12259685	201546	None	11	Rat	Binding	pKi	=	6.3	6.3	-6	4	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	285	2	1	2	3.9	CC(C)=CCN1CC[C@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm00039a008
	CHEMBL60542	201546	None	11	Rat	Binding	pKi	=	6.3	6.3	-6	4	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	285	2	1	2	3.9	CC(C)=CCN1CC[C@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm00039a008
	44378769	120040	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1cc2c(cc1S(=O)(=O)c1ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc1)OCO2	10.1016/s0960-894x(02)00024-0
	CHEMBL350404	120040	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1cc2c(cc1S(=O)(=O)c1ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc1)OCO2	10.1016/s0960-894x(02)00024-0
	156009698	178334	None	0	Human	Binding	pKi	=	7.3	7.3	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4634575	178334	None	0	Human	Binding	pKi	=	7.3	7.3	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651200	178334	None	0	Human	Binding	pKi	=	7.3	7.3	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	9846311	204009	None	12	Human	Binding	pKi	=	6.3	6.3	-346	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1016/s0960-894x(03)00350-0
	CHEMBL69678	204009	None	12	Human	Binding	pKi	=	6.3	6.3	-346	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1016/s0960-894x(03)00350-0
	9846311	204009	None	12	Human	Binding	pKi	=	6.3	6.3	-346	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
	CHEMBL69678	204009	None	12	Human	Binding	pKi	=	6.3	6.3	-346	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
	44309107	102173	None	0	Human	Binding	pKi	=	5.3	5.3	-8	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1ccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)cc1	10.1016/s0960-894x(03)00350-0
	CHEMBL302720	102173	None	0	Human	Binding	pKi	=	5.3	5.3	-8	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1ccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)cc1	10.1016/s0960-894x(03)00350-0
	10176401	154966	None	19	Rat	Binding	pKi	=	5.3	5.3	-1	2	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	CC1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	CHEMBL40121	154966	None	19	Rat	Binding	pKi	=	5.3	5.3	-1	2	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	CC1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	10344314	94111	None	0	Rat	Binding	pKi	=	6.3	6.3	-12	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	462	8	2	5	3.1	COC(=O)c1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
	CHEMBL249204	94111	None	0	Rat	Binding	pKi	=	6.3	6.3	-12	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	462	8	2	5	3.1	COC(=O)c1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
	11498	3017	None	41	Human	Binding	pKi	=	6.3	6.3	-67	6	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
	4995951	3017	None	41	Human	Binding	pKi	=	6.3	6.3	-67	6	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
	CHEMBL59898	3017	None	41	Human	Binding	pKi	=	6.3	6.3	-67	6	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
	11011332	120800	None	1	Human	Binding	pKi	=	5.3	5.3	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL355560	120800	None	1	Human	Binding	pKi	=	5.3	5.3	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	156010362	178330	None	0	Human	Binding	pKi	=	5.3	5.3	-	1	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4633296	178330	None	0	Human	Binding	pKi	=	5.3	5.3	-	1	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651171	178330	None	0	Human	Binding	pKi	=	5.3	5.3	-	1	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	11112362	4957	None	0	Human	Binding	pKi	=	5.3	5.3	-4	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	410	3	1	3	5.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(Cc5ccccc5)c34)OC21	10.1021/jm011116o
	CHEMBL104804	4957	None	0	Human	Binding	pKi	=	5.3	5.3	-4	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	410	3	1	3	5.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(Cc5ccccc5)c34)OC21	10.1021/jm011116o
	9998829	103417	None	0	Rat	Binding	pKi	=	7.3	7.3	2	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	363	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(C)(C)C)cc1)C2	10.1021/jm00020a006
	CHEMBL3084866	103417	None	0	Rat	Binding	pKi	=	7.3	7.3	2	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	363	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(C)(C)C)cc1)C2	10.1021/jm00020a006
	118710660	120829	None	0	Human	Binding	pKi	=	7.3	7.3	2	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323279	120829	None	0	Human	Binding	pKi	=	7.3	7.3	2	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558230	120829	None	0	Human	Binding	pKi	=	7.3	7.3	2	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	46682613	181154	None	1	Human	Binding	pKi	=	7.3	7.3	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760823	181154	None	1	Human	Binding	pKi	=	7.3	7.3	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	156014205	178290	None	0	Human	Binding	pKi	=	7.3	7.3	-5	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4635385	178290	None	0	Human	Binding	pKi	=	7.3	7.3	-5	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650957	178290	None	0	Human	Binding	pKi	=	7.3	7.3	-5	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	71575652	86196	None	0	Human	Binding	pKi	=	6.3	6.3	1	5	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	381	5	0	4	3.6	CN1CCC(c2ccccc2F)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
	CHEMBL2312352	86196	None	0	Human	Binding	pKi	=	6.3	6.3	1	5	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	381	5	0	4	3.6	CN1CCC(c2ccccc2F)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
	44308831	204393	None	0	Human	Binding	pKi	=	5.3	5.3	-44	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.2	CNCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL71933	204393	None	0	Human	Binding	pKi	=	5.3	5.3	-44	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.2	CNCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	44593627	193297	None	0	Human	Binding	pKi	=	6.3	6.3	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL524071	193297	None	0	Human	Binding	pKi	=	6.3	6.3	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL541671	193297	None	0	Human	Binding	pKi	=	6.3	6.3	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	44448417	11907	None	0	Human	Binding	pKi	=	5.3	5.3	-8	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182629	11907	None	0	Human	Binding	pKi	=	5.3	5.3	-8	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL256923	11907	None	0	Human	Binding	pKi	=	5.3	5.3	-8	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	57664406	2396	None	50	Human	Binding	pKi	=	5.3	5.3	-1	2	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	6938	2396	None	50	Human	Binding	pKi	=	5.3	5.3	-1	2	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089376	2396	None	50	Human	Binding	pKi	=	5.3	5.3	-1	2	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	44308832	203811	None	0	Human	Binding	pKi	=	7.3	7.3	-45	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	364	4	2	3	2.8	NCC=C1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL68384	203811	None	0	Human	Binding	pKi	=	7.3	7.3	-45	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	364	4	2	3	2.8	NCC=C1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	14964495	12611	None	1	Rat	Binding	pKi	=	7.3	7.3	4	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118700	12611	None	1	Rat	Binding	pKi	=	7.3	7.3	4	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	2733619	11909	None	8	Human	Binding	pKi	=	7.3	7.3	-1	5	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	6508725	11909	None	8	Human	Binding	pKi	=	7.3	7.3	-1	5	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	CHEMBL1182634	11909	None	8	Human	Binding	pKi	=	7.3	7.3	-1	5	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	CHEMBL257431	11909	None	8	Human	Binding	pKi	=	7.3	7.3	-1	5	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	10475156	121521	None	0	Human	Binding	pKi	=	5.3	5.3	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	258	1	1	2	2.5	C[N+]12CCC(CC1)C(O)(c1cc3ccccc3o1)C2	10.1021/jm00003a011
	CHEMBL358493	121521	None	0	Human	Binding	pKi	=	5.3	5.3	-1	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	258	1	1	2	2.5	C[N+]12CCC(CC1)C(O)(c1cc3ccccc3o1)C2	10.1021/jm00003a011
	15086393	13289	None	0	Rat	Binding	pKi	=	6.3	6.3	-3	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1191772	13289	None	0	Rat	Binding	pKi	=	6.3	6.3	-3	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL542914	13289	None	0	Rat	Binding	pKi	=	6.3	6.3	-3	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
	71457691	83797	None	0	Human	Binding	pKi	=	6.3	6.3	-1	10	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccccc1CN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	CHEMBL2205823	83797	None	0	Human	Binding	pKi	=	6.3	6.3	-1	10	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccccc1CN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	16125640	84740	None	0	Human	Binding	pKi	=	6.3	6.3	-1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	486	10	1	3	4.3	COCC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222917	84740	None	0	Human	Binding	pKi	=	6.3	6.3	-1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	486	10	1	3	4.3	COCC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	205895	11866	None	2	Rat	Binding	pKi	=	7.3	7.3	1	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	CHEMBL118240	11866	None	2	Rat	Binding	pKi	=	7.3	7.3	1	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	10457079	10028	None	0	Human	Binding	pKi	=	6.3	6.3	-4	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL115078	10028	None	0	Human	Binding	pKi	=	6.3	6.3	-4	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	137645938	157581	None	0	Human	Binding	pKi	=	6.3	6.3	-407	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	342	8	0	2	4.6	CCCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4080675	157581	None	0	Human	Binding	pKi	=	6.3	6.3	-407	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	342	8	0	2	4.6	CCCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	44593617	187429	None	0	Human	Binding	pKi	=	6.3	6.3	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493795	187429	None	0	Human	Binding	pKi	=	6.3	6.3	-2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	44443733	154782	None	0	Rat	Binding	pKi	=	6.3	6.3	-45	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL400167	154782	None	0	Rat	Binding	pKi	=	6.3	6.3	-45	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	202119	12033	None	3	Rat	Binding	pKi	=	5.3	5.3	1	3	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL1183388	12033	None	3	Rat	Binding	pKi	=	5.3	5.3	1	3	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL294470	12033	None	3	Rat	Binding	pKi	=	5.3	5.3	1	3	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	71461700	79592	None	0	Rat	Binding	pKi	=	5.3	5.3	7	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@@H]1CCCN1	10.1021/jm00087a008
	CHEMBL2114425	79592	None	0	Rat	Binding	pKi	=	5.3	5.3	7	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@@H]1CCCN1	10.1021/jm00087a008
	15678860	102381	None	0	Rat	Binding	pKi	=	7.2	7.2	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	450	9	2	6	2.8	NCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL303876	102381	None	0	Rat	Binding	pKi	=	7.2	7.2	1	2	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	450	9	2	6	2.8	NCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	44593627	193297	None	0	Human	Binding	pKi	=	7.2	7.2	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL524071	193297	None	0	Human	Binding	pKi	=	7.2	7.2	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL541671	193297	None	0	Human	Binding	pKi	=	7.2	7.2	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	145961161	161604	None	0	Human	Binding	pKi	=	7.2	7.2	-6	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	CHEMBL4129580	161604	None	0	Human	Binding	pKi	=	7.2	7.2	-6	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	44382880	120758	None	0	Human	Binding	pKi	=	6.2	6.2	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	362	4	1	4	3.5	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C(C)CN1	10.1016/s0960-894x(99)00101-8
	CHEMBL355193	120758	None	0	Human	Binding	pKi	=	6.2	6.2	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	362	4	1	4	3.5	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C(C)CN1	10.1016/s0960-894x(99)00101-8
	137629744	161173	None	0	Human	Binding	pKi	=	5.2	5.2	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4071109	161173	None	0	Human	Binding	pKi	=	5.2	5.2	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117602	161173	None	0	Human	Binding	pKi	=	5.2	5.2	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44392984	12255	None	0	Human	Binding	pKi	=	6.2	6.2	-1	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL1184654	12255	None	0	Human	Binding	pKi	=	6.2	6.2	-1	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL362864	12255	None	0	Human	Binding	pKi	=	6.2	6.2	-1	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	483747	105407	None	3	Human	Binding	pKi	=	6.2	6.2	-177	4	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL311795	105407	None	3	Human	Binding	pKi	=	6.2	6.2	-177	4	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	10066369	120256	None	0	Human	Binding	pKi	=	6.2	6.2	8	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL352375	120256	None	0	Human	Binding	pKi	=	6.2	6.2	8	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	133640439	181371	None	1	Human	Binding	pKi	=	6.2	6.2	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4763304	181371	None	1	Human	Binding	pKi	=	6.2	6.2	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	611107	203942	None	1	Rat	Binding	pKi	=	5.2	5.2	-1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	451	7	3	7	0.4	NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL69287	203942	None	1	Rat	Binding	pKi	=	5.2	5.2	-1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	451	7	3	7	0.4	NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	71458134	79686	None	0	Rat	Binding	pKi	=	5.2	5.2	-1	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL2115362	79686	None	0	Rat	Binding	pKi	=	5.2	5.2	-1	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	11120347	120727	None	0	Human	Binding	pKi	=	6.2	6.2	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
	CHEMBL354841	120727	None	0	Human	Binding	pKi	=	6.2	6.2	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
	15678858	102147	None	0	Rat	Binding	pKi	=	5.2	5.2	-5	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	7	2	6	2.1	NCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL302544	102147	None	0	Rat	Binding	pKi	=	5.2	5.2	-5	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	7	2	6	2.1	NCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	59291578	112783	None	0	Rat	Binding	pKi	=	7.2	7.2	-6	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298594	112783	None	0	Rat	Binding	pKi	=	7.2	7.2	-6	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305763	112783	None	0	Rat	Binding	pKi	=	7.2	7.2	-6	3	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	1726	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1726	2495	None	13	Human	Binding	pKi	=	7.2	7.2	-2	5	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2495	None	13	Human	Binding	pKi	=	7.2	7.2	-2	5	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2495	None	13	Human	Binding	pKi	=	7.2	7.2	-2	5	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2495	None	13	Human	Binding	pKi	=	7.2	7.2	-2	5	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2495	None	13	Human	Binding	pKi	=	7.2	7.2	-2	5	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	44383305	59351	None	0	Human	Binding	pKi	=	7.2	7.2	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	578	8	0	8	4.2	O=C(COc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL170739	59351	None	0	Human	Binding	pKi	=	7.2	7.2	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	578	8	0	8	4.2	O=C(COc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	4098	32503	None	30	Human	Binding	pKi	=	6.2	6.2	-15	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1255739	32503	None	30	Human	Binding	pKi	=	6.2	6.2	-15	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1411979	32503	None	30	Human	Binding	pKi	=	6.2	6.2	-15	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	44383373	59388	None	0	Human	Binding	pKi	=	6.2	6.2	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	348	4	0	4	3.0	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL170922	59388	None	0	Human	Binding	pKi	=	6.2	6.2	-1	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	348	4	0	4	3.0	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	44295953	189034	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4c[nH]c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL50927	189034	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4c[nH]c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44382739	120394	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	516	6	0	8	3.7	CCOC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL353465	120394	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	516	6	0	8	3.7	CCOC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	9905731	168506	None	0	Human	Binding	pKi	=	8.2	8.2	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL435353	168506	None	0	Human	Binding	pKi	=	8.2	8.2	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	119357	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
	3264	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
	368	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
	CHEMBL279453	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
	44428745	92175	None	0	Human	Binding	pKi	=	8.2	8.2	3	5	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	635	23	2	6	7.9	COc1ccccc1CNCCCCCCN1CCC(CCC2CCN(CCCCCCNCc3ccccc3OC)CC2)CC1	10.1016/j.bmc.2007.01.022
	CHEMBL242345	92175	None	0	Human	Binding	pKi	=	8.2	8.2	3	5	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	635	23	2	6	7.9	COc1ccccc1CNCCCCCCN1CCC(CCC2CCN(CCCCCCNCc3ccccc3OC)CC2)CC1	10.1016/j.bmc.2007.01.022
	119357	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
	3264	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
	368	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
	CHEMBL279453	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
	46188794	178317	None	0	Human	Binding	pKi	=	8.2	8.2	-19	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4645580	178317	None	0	Human	Binding	pKi	=	8.2	8.2	-19	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651099	178317	None	0	Human	Binding	pKi	=	8.2	8.2	-19	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	44267747	10059	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	4	7.7	CC(C)Oc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
	CHEMBL11527	10059	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	4	7.7	CC(C)Oc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
	118710670	120831	None	0	Human	Binding	pKi	=	8.2	8.2	-1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323284	120831	None	0	Human	Binding	pKi	=	8.2	8.2	-1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558233	120831	None	0	Human	Binding	pKi	=	8.2	8.2	-1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	11531644	176411	None	1	Human	Binding	pKi	=	8.2	8.2	-	1	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
	CHEMBL4560341	176411	None	1	Human	Binding	pKi	=	8.2	8.2	-	1	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
	CHEMBL4596085	176411	None	1	Human	Binding	pKi	=	8.2	8.2	-	1	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
	44431382	88019	None	0	Human	Binding	pKi	=	8.2	8.2	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234438	88019	None	0	Human	Binding	pKi	=	8.2	8.2	-2	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	199230	163133	None	21	Rat	Binding	pKi	=	8.2	8.2	37	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	CHEMBL41779	163133	None	21	Rat	Binding	pKi	=	8.2	8.2	37	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	10086238	78906	None	0	Rat	Binding	pKi	=	8.2	8.2	-	1	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	301	7	0	5	3.5	CN1CCC=C(c2nsnc2SCCCCCF)C1	10.1021/jm00001a002
	CHEMBL2112940	78906	None	0	Rat	Binding	pKi	=	8.2	8.2	-	1	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	301	7	0	5	3.5	CN1CCC=C(c2nsnc2SCCCCCF)C1	10.1021/jm00001a002
	66875589	103388	None	0	Human	Binding	pKi	=	8.2	8.2	-7	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084662	103388	None	0	Human	Binding	pKi	=	8.2	8.2	-7	3	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10155225	95838	None	0	Human	Binding	pKi	=	8.2	8.2	-2	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	3	3.6	COC1(C#CC(C#N)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL258959	95838	None	0	Human	Binding	pKi	=	8.2	8.2	-2	2	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	3	3.6	COC1(C#CC(C#N)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	14210083	156710	None	1	Human	Binding	pKi	=	8.2	8.2	-	1	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	CHEMBL4070155	156710	None	1	Human	Binding	pKi	=	8.2	8.2	-	1	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	118710670	120831	None	0	Human	Binding	pKi	=	8.2	8.2	-1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323284	120831	None	0	Human	Binding	pKi	=	8.2	8.2	-1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558233	120831	None	0	Human	Binding	pKi	=	8.2	8.2	-1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	10163651	163231	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL418446	163231	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL5273907	193783	None	0	Human	Binding	pKi	=	8.2	8.2	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	945	20	2	5	13.3	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
	44627740	198756	None	0	Human	Binding	pKi	=	8.2	8.2	-5	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL583051	198756	None	0	Human	Binding	pKi	=	8.2	8.2	-5	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	10497101	70467	None	0	Rat	Binding	pKi	=	8.2	8.2	-4	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	336	4	1	3	3.6	O=C(NC(c1ccccc1)c1ccccc1)OC1CN2CCC1CC2	10.1021/jm050099q
	CHEMBL194628	70467	None	0	Rat	Binding	pKi	=	8.2	8.2	-4	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	336	4	1	3	3.6	O=C(NC(c1ccccc1)c1ccccc1)OC1CN2CCC1CC2	10.1021/jm050099q
	13773336	79681	None	0	Rat	Binding	pKi	=	8.2	8.2	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2115342	79681	None	0	Rat	Binding	pKi	=	8.2	8.2	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	9894136	166234	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	9	0	8	3.7	CCCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL426761	166234	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	9	0	8	3.7	CCCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	939077	195066	None	2	Rat	Binding	pKi	=	8.2	8.2	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	CHEMBL549577	195066	None	2	Rat	Binding	pKi	=	8.2	8.2	-	1	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	2705	3840	None	64	Rat	Binding	pKi	=	8.2	8.2	-1	10	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
	360	3840	None	64	Rat	Binding	pKi	=	8.2	8.2	-1	10	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
	443879	3840	None	64	Rat	Binding	pKi	=	8.2	8.2	-1	10	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
	CHEMBL1382	3840	None	64	Rat	Binding	pKi	=	8.2	8.2	-1	10	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
	DB01036	3840	None	64	Rat	Binding	pKi	=	8.2	8.2	-1	10	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
	118710668	120832	None	0	Human	Binding	pKi	=	8.2	8.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3323283	120832	None	0	Human	Binding	pKi	=	8.2	8.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3558234	120832	None	0	Human	Binding	pKi	=	8.2	8.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	2028	2977	None	80	Rat	Binding	pKi	=	8.2	8.2	-5	11	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
	359	2977	None	80	Rat	Binding	pKi	=	8.2	8.2	-5	11	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
	4634	2977	None	80	Rat	Binding	pKi	=	8.2	8.2	-5	11	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
	CHEMBL1231	2977	None	80	Rat	Binding	pKi	=	8.2	8.2	-5	11	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
	DB01062	2977	None	80	Rat	Binding	pKi	=	8.2	8.2	-5	11	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
	302	2975	None	25	Rat	Binding	pKi	=	7.2	7.2	-4	8	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	4630	2975	None	25	Rat	Binding	pKi	=	7.2	7.2	-4	8	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL7634	2975	None	25	Rat	Binding	pKi	=	7.2	7.2	-4	8	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	303	2976	None	17	Rat	Binding	pKi	=	7.2	7.2	1	6	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	4629	2976	None	17	Rat	Binding	pKi	=	7.2	7.2	1	6	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	8595	2976	None	17	Rat	Binding	pKi	=	7.2	7.2	1	6	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL44674	2976	None	17	Rat	Binding	pKi	=	7.2	7.2	1	6	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	44627854	197707	None	0	Human	Binding	pKi	=	7.2	7.2	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL571341	197707	None	0	Human	Binding	pKi	=	7.2	7.2	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	156015971	178280	None	0	Human	Binding	pKi	=	7.2	7.2	-3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4648444	178280	None	0	Human	Binding	pKi	=	7.2	7.2	-3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650880	178280	None	0	Human	Binding	pKi	=	7.2	7.2	-3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	9991979	119156	None	1	Human	Binding	pKi	=	6.2	6.2	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	3	3.4	C1=C(c2nc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL342958	119156	None	1	Human	Binding	pKi	=	6.2	6.2	-3	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	3	3.4	C1=C(c2nc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
	14964507	114353	None	1	Rat	Binding	pKi	=	5.2	5.2	-5	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL333107	114353	None	1	Rat	Binding	pKi	=	5.2	5.2	-5	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	75356563	156955	None	23	Human	Binding	pKi	=	5.2	5.2	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	CHEMBL4072787	156955	None	23	Human	Binding	pKi	=	5.2	5.2	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	118719926	115778	None	0	Human	Binding	pKi	=	6.2	6.2	-138	8	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	358	9	1	3	3.6	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1	10.1021/jm501173q
	CHEMBL3354073	115778	None	0	Human	Binding	pKi	=	6.2	6.2	-138	8	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	358	9	1	3	3.6	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1	10.1021/jm501173q
	11001809	59079	None	0	Human	Binding	pKi	=	5.2	5.2	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL169594	59079	None	0	Human	Binding	pKi	=	5.2	5.2	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	46227461	14134	None	0	Human	Binding	pKi	=	4.2	4.2	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL1198077	14134	None	0	Human	Binding	pKi	=	4.2	4.2	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL594803	14134	None	0	Human	Binding	pKi	=	4.2	4.2	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	631644	204075	None	1	Rat	Binding	pKi	=	5.2	5.2	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	551	8	3	8	2.0	CC(C)(C)OC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL70133	204075	None	1	Rat	Binding	pKi	=	5.2	5.2	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	551	8	3	8	2.0	CC(C)(C)OC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	118710664	120830	None	0	Human	Binding	pKi	=	7.2	7.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323281	120830	None	0	Human	Binding	pKi	=	7.2	7.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558231	120830	None	0	Human	Binding	pKi	=	7.2	7.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	60138186	120834	None	0	Human	Binding	pKi	=	7.2	7.2	23	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	60138193	120834	None	0	Human	Binding	pKi	=	7.2	7.2	23	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323288	120834	None	0	Human	Binding	pKi	=	7.2	7.2	23	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558240	120834	None	0	Human	Binding	pKi	=	7.2	7.2	23	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	145960827	161378	None	0	Human	Binding	pKi	=	7.2	7.2	-1	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	CHEMBL4126290	161378	None	0	Human	Binding	pKi	=	7.2	7.2	-1	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	2200	3129	None	46	Rat	Binding	pKi	=	6.2	6.2	-31	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
	328	3129	None	46	Rat	Binding	pKi	=	6.2	6.2	-31	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
	4848	3129	None	46	Rat	Binding	pKi	=	6.2	6.2	-31	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	6.2	6.2	-31	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
	DB00670	3129	None	46	Rat	Binding	pKi	=	6.2	6.2	-31	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
	1353	1909	None	93	Rat	Binding	pKi	=	5.2	5.2	-338	86	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	3559	1909	None	93	Rat	Binding	pKi	=	5.2	5.2	-338	86	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	86	1909	None	93	Rat	Binding	pKi	=	5.2	5.2	-338	86	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	CHEMBL54	1909	None	93	Rat	Binding	pKi	=	5.2	5.2	-338	86	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	DB00502	1909	None	93	Rat	Binding	pKi	=	5.2	5.2	-338	86	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	502259	116796	None	1	Human	Binding	pKi	=	6.2	6.2	-61	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	571	4	0	5	5.9	Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL337820	116796	None	1	Human	Binding	pKi	=	6.2	6.2	-61	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	571	4	0	5	5.9	Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	909982	202092	None	10	Human	Binding	pKi	=	6.2	6.2	-	1	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
	CHEMBL608828	202092	None	10	Human	Binding	pKi	=	6.2	6.2	-	1	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
	162353390	180947	None	0	Human	Binding	pKi	=	6.2	6.2	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4758316	180947	None	0	Human	Binding	pKi	=	6.2	6.2	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	109035056	181321	None	1	Human	Binding	pKi	=	6.2	6.2	7	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	CHEMBL4762755	181321	None	1	Human	Binding	pKi	=	6.2	6.2	7	3	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	164609373	188462	None	0	Human	Binding	pKi	=	5.2	5.2	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL4846035	188462	None	0	Human	Binding	pKi	=	5.2	5.2	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL5027958	188462	None	0	Human	Binding	pKi	=	5.2	5.2	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	162353378	182909	None	0	Human	Binding	pKi	=	5.2	5.2	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4792360	182909	None	0	Human	Binding	pKi	=	5.2	5.2	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	44446841	12336	None	0	Human	Binding	pKi	=	4.2	4.2	2	4	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL1185281	12336	None	0	Human	Binding	pKi	=	4.2	4.2	2	4	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL404557	12336	None	0	Human	Binding	pKi	=	4.2	4.2	2	4	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	11819882	17441	None	0	Human	Binding	pKi	=	6.2	6.2	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2cccs2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL125764	17441	None	0	Human	Binding	pKi	=	6.2	6.2	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2cccs2)C2CCN1CC2	10.1021/jm00003a011
	16124769	84778	None	0	Human	Binding	pKi	=	6.2	6.2	-23	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	0	2	5.3	O=C1N(C2CCN(Cc3ccccc3)CC2)CC(c2ccccc2)N1Cc1ccccc1	10.1021/jm061159a
	CHEMBL223188	84778	None	0	Human	Binding	pKi	=	6.2	6.2	-23	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	0	2	5.3	O=C1N(C2CCN(Cc3ccccc3)CC2)CC(c2ccccc2)N1Cc1ccccc1	10.1021/jm061159a
	319	1323	None	44	Rat	Binding	pKi	=	7.2	7.2	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	321	1323	None	44	Rat	Binding	pKi	=	7.2	7.2	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	444031	1323	None	44	Rat	Binding	pKi	=	7.2	7.2	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	784	1323	None	44	Rat	Binding	pKi	=	7.2	7.2	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	CHEMBL1346	1323	None	44	Rat	Binding	pKi	=	7.2	7.2	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	DB00496	1323	None	44	Rat	Binding	pKi	=	7.2	7.2	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	10125445	76026	None	0	Human	Binding	pKi	=	7.2	7.2	-25	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
	CHEMBL205654	76026	None	0	Human	Binding	pKi	=	7.2	7.2	-25	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
	164615651	188509	None	0	Human	Binding	pKi	=	7.2	7.2	41	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	188509	None	0	Human	Binding	pKi	=	7.2	7.2	41	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	188509	None	0	Human	Binding	pKi	=	7.2	7.2	41	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	16094793	83320	None	0	Human	Binding	pKi	=	7.2	7.2	-1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsc(OCCCOCCCOCCCOc2nsnc2-c2cccnc2)n1	10.1021/jm0606995
	CHEMBL219118	83320	None	0	Human	Binding	pKi	=	7.2	7.2	-1	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsc(OCCCOCCCOCCCOc2nsnc2-c2cccnc2)n1	10.1021/jm0606995
	9799291	160118	None	0	Human	Binding	pKi	=	6.2	6.2	-169	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	2	3	2.9	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL410890	160118	None	0	Human	Binding	pKi	=	6.2	6.2	-169	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	2	3	2.9	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	14964497	14289	None	0	Rat	Binding	pKi	=	6.2	6.2	-	1	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119985	14289	None	0	Rat	Binding	pKi	=	6.2	6.2	-	1	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	3013846	188237	None	2	Human	Binding	pKi	=	6.2	6.2	-4	5	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
	CHEMBL499519	188237	None	2	Human	Binding	pKi	=	6.2	6.2	-4	5	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
	137631178	161202	None	0	Human	Binding	pKi	=	6.2	6.2	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4081662	161202	None	0	Human	Binding	pKi	=	6.2	6.2	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117768	161202	None	0	Human	Binding	pKi	=	6.2	6.2	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44443728	94030	None	0	Rat	Binding	pKi	=	6.2	6.2	-25	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.9	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL248809	94030	None	0	Rat	Binding	pKi	=	6.2	6.2	-25	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.9	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	44318969	206078	None	0	Human	Binding	pKi	=	6.2	6.2	-3	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	5.0	O=C(c1ccccc1)N(Cc1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85568	206078	None	0	Human	Binding	pKi	=	6.2	6.2	-3	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	5.0	O=C(c1ccccc1)N(Cc1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319016	206135	None	0	Human	Binding	pKi	=	6.2	6.2	-25	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccc(Cl)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL86012	206135	None	0	Human	Binding	pKi	=	6.2	6.2	-25	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccc(Cl)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319017	206307	None	0	Human	Binding	pKi	=	6.2	6.2	-19	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccc(Br)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL87132	206307	None	0	Human	Binding	pKi	=	6.2	6.2	-19	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccc(Br)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	10418420	70271	None	0	Rat	Binding	pKi	=	6.2	6.2	-47	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	955	27	0	10	10.9	CN(CCCCCCCCN(C)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00113-8
	CHEMBL194216	70271	None	0	Rat	Binding	pKi	=	6.2	6.2	-47	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	955	27	0	10	10.9	CN(CCCCCCCCN(C)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00113-8
	11169365	112510	None	0	Human	Binding	pKi	=	6.2	6.2	-99	2	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298986	112510	None	0	Human	Binding	pKi	=	6.2	6.2	-99	2	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	137630084	161043	None	0	Human	Binding	pKi	=	5.2	5.2	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4070055	161043	None	0	Human	Binding	pKi	=	5.2	5.2	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116507	161043	None	0	Human	Binding	pKi	=	5.2	5.2	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
	57326140	77177	None	0	Human	Binding	pKi	=	5.2	5.2	2	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL2042400	77177	None	0	Human	Binding	pKi	=	5.2	5.2	2	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL2078962	77177	None	0	Human	Binding	pKi	=	5.2	5.2	2	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	44406451	72940	None	0	Human	Binding	pKi	=	6.2	6.2	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	385	2	1	3	3.8	CO[C@]1(C#CC(O)C2c3ccccc3C=Cc3ccccc32)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200566	72940	None	0	Human	Binding	pKi	=	6.2	6.2	-6	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	385	2	1	3	3.8	CO[C@]1(C#CC(O)C2c3ccccc3C=Cc3ccccc32)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	542182	102159	None	1	Rat	Binding	pKi	=	5.2	5.2	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	465	8	3	7	0.8	NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL302604	102159	None	1	Rat	Binding	pKi	=	5.2	5.2	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	465	8	3	7	0.8	NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	71460014	79684	None	0	Rat	Binding	pKi	=	6.2	6.2	4	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@H]1CCCCN1	10.1021/jm00087a008
	CHEMBL2115360	79684	None	0	Rat	Binding	pKi	=	6.2	6.2	4	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@H]1CCCCN1	10.1021/jm00087a008
	44400887	70996	None	0	Rat	Binding	pKi	=	6.2	6.2	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	360	5	2	3	2.0	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
	CHEMBL195169	70996	None	0	Rat	Binding	pKi	=	6.2	6.2	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	360	5	2	3	2.0	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
	60138186	120834	None	0	Human	Binding	pKi	=	7.2	7.2	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	60138193	120834	None	0	Human	Binding	pKi	=	7.2	7.2	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323288	120834	None	0	Human	Binding	pKi	=	7.2	7.2	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558240	120834	None	0	Human	Binding	pKi	=	7.2	7.2	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	44627741	197680	None	0	Human	Binding	pKi	=	7.2	7.2	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	317	4	0	2	5.2	CN1CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL571123	197680	None	0	Human	Binding	pKi	=	7.2	7.2	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	317	4	0	2	5.2	CN1CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	44593619	187458	None	0	Human	Binding	pKi	=	7.2	7.2	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493980	187458	None	0	Human	Binding	pKi	=	7.2	7.2	-6	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	44308746	203849	None	0	Human	Binding	pKi	=	6.2	6.2	-138	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	3	2	3	2.6	CC1(N)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL68609	203849	None	0	Human	Binding	pKi	=	6.2	6.2	-138	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	3	2	3	2.6	CC1(N)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	10572658	121978	None	0	Human	Binding	pKi	=	5.2	5.2	-33	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccncc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL359197	121978	None	0	Human	Binding	pKi	=	5.2	5.2	-33	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccncc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	167962	4067	None	4	Human	Binding	pKi	=	6.2	6.2	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4067	None	4	Human	Binding	pKi	=	6.2	6.2	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4067	None	4	Human	Binding	pKi	=	6.2	6.2	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	162675053	183256	None	0	Human	Binding	pKi	=	6.2	6.2	-1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4796491	183256	None	0	Human	Binding	pKi	=	6.2	6.2	-1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	44578707	182139	None	0	Human	Binding	pKi	=	6.2	6.2	2	3	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@@H]21	10.1016/j.bmc.2008.06.025
	CHEMBL478227	182139	None	0	Human	Binding	pKi	=	6.2	6.2	2	3	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@@H]21	10.1016/j.bmc.2008.06.025
	57664406	2396	None	50	Human	Binding	pKi	=	5.2	5.2	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	6938	2396	None	50	Human	Binding	pKi	=	5.2	5.2	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089376	2396	None	50	Human	Binding	pKi	=	5.2	5.2	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	164618644	188529	None	0	Human	Binding	pKi	=	5.2	5.2	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL4872142	188529	None	0	Human	Binding	pKi	=	5.2	5.2	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL5028508	188529	None	0	Human	Binding	pKi	=	5.2	5.2	-	1	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	57326144	77189	None	0	Human	Binding	pKi	=	5.2	5.2	1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042402	77189	None	0	Human	Binding	pKi	=	5.2	5.2	1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2079061	77189	None	0	Human	Binding	pKi	=	5.2	5.2	1	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
	10457079	10028	None	0	Human	Binding	pKi	=	4.2	4.2	-4	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL115078	10028	None	0	Human	Binding	pKi	=	4.2	4.2	-4	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	162353389	181522	None	0	Human	Binding	pKi	=	4.2	4.2	-	1	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	2	3	3.3	O=C(CCN1CCCc2ccccc21)Nc1ccc(O)cc1F	10.1016/j.bmcl.2020.127632
	CHEMBL4765133	181522	None	0	Human	Binding	pKi	=	4.2	4.2	-	1	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	2	3	3.3	O=C(CCN1CCCc2ccccc21)Nc1ccc(O)cc1F	10.1016/j.bmcl.2020.127632
	44443735	94381	None	0	Rat	Binding	pKi	=	6.2	6.2	-52	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)[C@](O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL250834	94381	None	0	Rat	Binding	pKi	=	6.2	6.2	-52	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)[C@](O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	9998202	69164	None	0	Rat	Binding	pKi	=	7.2	7.2	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL192485	69164	None	0	Rat	Binding	pKi	=	7.2	7.2	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	44420821	84286	None	0	Human	Binding	pKi	=	7.2	7.2	-15	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	2	5.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CC2CCC(C1)N2Cc1ccccc1	10.1021/jm061159a
	CHEMBL221400	84286	None	0	Human	Binding	pKi	=	7.2	7.2	-15	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	2	5.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CC2CCC(C1)N2Cc1ccccc1	10.1021/jm061159a
	44383352	59690	None	0	Human	Binding	pKi	=	6.2	6.2	-2	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCC(N4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL172272	59690	None	0	Human	Binding	pKi	=	6.2	6.2	-2	2	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCC(N4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	10096017	103443	None	0	Rat	Binding	pKi	=	7.2	7.2	1	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	463	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Br)cc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
	CHEMBL3084897	103443	None	0	Rat	Binding	pKi	=	7.2	7.2	1	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	463	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Br)cc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
	118719920	115771	None	0	Human	Binding	pKi	=	7.2	7.2	-2	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	509	10	0	7	4.5	CN1CCC=C(c2nsnc2OCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354066	115771	None	0	Human	Binding	pKi	=	7.2	7.2	-2	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	509	10	0	7	4.5	CN1CCC=C(c2nsnc2OCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	44593620	187934	None	0	Human	Binding	pKi	=	7.2	7.2	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496915	187934	None	0	Human	Binding	pKi	=	7.2	7.2	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	302	2975	None	25	Human	Binding	pKi	=	6.2	6.2	-34	8	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	4630	2975	None	25	Human	Binding	pKi	=	6.2	6.2	-34	8	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	CHEMBL7634	2975	None	25	Human	Binding	pKi	=	6.2	6.2	-34	8	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	2551	793	None	23	Mouse	Binding	pKi	=	4.2	4.2	-8	11	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	298	793	None	23	Mouse	Binding	pKi	=	4.2	4.2	-8	11	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	488	793	None	23	Mouse	Binding	pKi	=	4.2	4.2	-8	11	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	CHEMBL965	793	None	23	Mouse	Binding	pKi	=	4.2	4.2	-8	11	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	DB00411	793	None	23	Mouse	Binding	pKi	=	4.2	4.2	-8	11	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	71450550	83805	None	0	Human	Binding	pKi	=	6.2	6.2	-1	16	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	CHEMBL2205836	83805	None	0	Human	Binding	pKi	=	6.2	6.2	-1	16	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	156017826	177856	None	0	Human	Binding	pKi	=	7.2	7.2	-3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4644285	177856	None	0	Human	Binding	pKi	=	7.2	7.2	-3	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	10408160	13048	None	0	Rat	Binding	pKi	=	6.2	6.2	-3	2	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
	CHEMBL1190020	13048	None	0	Rat	Binding	pKi	=	6.2	6.2	-3	2	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
	CHEMBL540013	13048	None	0	Rat	Binding	pKi	=	6.2	6.2	-3	2	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
	44299589	196395	None	0	Human	Binding	pKi	=	6.2	6.2	1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL56275	196395	None	0	Human	Binding	pKi	=	6.2	6.2	1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	44450624	95934	None	0	Human	Binding	pKi	=	6.2	6.2	12	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	CHEMBL259344	95934	None	0	Human	Binding	pKi	=	6.2	6.2	12	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	11045444	59187	None	0	Human	Binding	pKi	=	6.2	6.2	-2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL170088	59187	None	0	Human	Binding	pKi	=	6.2	6.2	-2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	11000399	59093	None	0	Human	Binding	pKi	=	5.2	5.2	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL169680	59093	None	0	Human	Binding	pKi	=	5.2	5.2	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
	463209	121130	None	1	Human	Binding	pKi	=	7.2	7.2	-6	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	519	5	0	6	4.8	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(OC(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL357557	121130	None	1	Human	Binding	pKi	=	7.2	7.2	-6	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	519	5	0	6	4.8	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(OC(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	134272502	176306	None	0	Human	Binding	pKi	=	7.2	7.2	2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4514058	176306	None	0	Human	Binding	pKi	=	7.2	7.2	2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4595246	176306	None	0	Human	Binding	pKi	=	7.2	7.2	2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	44392974	64538	None	0	Human	Binding	pKi	=	7.2	7.2	2	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	343	2	0	3	4.5	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL181447	64538	None	0	Human	Binding	pKi	=	7.2	7.2	2	2	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	343	2	0	3	4.5	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	16086062	80789	None	0	Human	Binding	pKi	=	7.2	7.2	-128	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	11	2	5	5.4	O=C(NCC1CCN(CC2CCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL215189	80789	None	0	Human	Binding	pKi	=	7.2	7.2	-128	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	11	2	5	5.4	O=C(NCC1CCN(CC2CCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	44308809	204379	None	0	Human	Binding	pKi	=	5.2	5.2	-123	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	3	3	2.9	NCC1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL71799	204379	None	0	Human	Binding	pKi	=	5.2	5.2	-123	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	3	3	2.9	NCC1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	56963799	74893	None	0	Human	Binding	pKi	=	6.2	6.2	-1698	10	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
	CHEMBL2031737	74893	None	0	Human	Binding	pKi	=	6.2	6.2	-1698	10	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
	132060812	162034	None	0	Human	Binding	pKi	=	5.2	5.2	-1778	10	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	CHEMBL4160064	162034	None	0	Human	Binding	pKi	=	5.2	5.2	-1778	10	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	4011	82406	None	49	Human	Binding	pKi	=	6.2	6.2	-35	24	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	CHEMBL21731	82406	None	49	Human	Binding	pKi	=	6.2	6.2	-35	24	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	44593622	187794	None	0	Human	Binding	pKi	=	7.2	7.2	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL495888	187794	None	0	Human	Binding	pKi	=	7.2	7.2	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL556390	187794	None	0	Human	Binding	pKi	=	7.2	7.2	1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	10647553	39716	None	0	Human	Binding	pKi	=	5.2	5.2	-407	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	3	4	3.6	O=C(NC1CCN(Cc2cccc(CO)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL147554	39716	None	0	Human	Binding	pKi	=	5.2	5.2	-407	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	3	4	3.6	O=C(NC1CCN(Cc2cccc(CO)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	44422699	11849	None	0	Human	Binding	pKi	=	5.2	5.2	5	4	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL1182272	11849	None	0	Human	Binding	pKi	=	5.2	5.2	5	4	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL227378	11849	None	0	Human	Binding	pKi	=	5.2	5.2	5	4	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	10473919	204729	None	0	Human	Binding	pKi	=	6.2	6.2	1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	363	11	0	5	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccc(OC)cc2)CCCC1	10.1021/jm00041a006
	CHEMBL74305	204729	None	0	Human	Binding	pKi	=	6.2	6.2	1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	363	11	0	5	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccc(OC)cc2)CCCC1	10.1021/jm00041a006
	16125571	85148	None	0	Human	Binding	pKi	=	6.2	6.2	-79	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	CHEMBL225074	85148	None	0	Human	Binding	pKi	=	6.2	6.2	-79	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	66561967	74702	None	0	Human	Binding	pKi	=	6.2	6.2	-1	7	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	213	2	0	1	2.0	C1CC2CCC1N2CC12C3C4C5C3C1C5C42	10.1016/j.bmcl.2012.04.077
	CHEMBL2030626	74702	None	0	Human	Binding	pKi	=	6.2	6.2	-1	7	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	213	2	0	1	2.0	C1CC2CCC1N2CC12C3C4C5C3C1C5C42	10.1016/j.bmcl.2012.04.077
	44295888	188255	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	461	6	1	3	4.7	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL49975	188255	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	461	6	1	3	4.7	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	9815331	203105	None	1	Human	Binding	pKi	=	8.2	8.2	-1	8	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	CHEMBL64000	203105	None	1	Human	Binding	pKi	=	8.2	8.2	-1	8	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	174174	523	None	49	Human	Binding	pKi	=	8.2	8.2	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	523	None	49	Human	Binding	pKi	=	8.2	8.2	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	523	None	49	Human	Binding	pKi	=	8.2	8.2	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.2	8.2	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	523	None	49	Human	Binding	pKi	=	8.2	8.2	-7	14	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	118710668	120832	None	0	Human	Binding	pKi	=	8.2	8.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3323283	120832	None	0	Human	Binding	pKi	=	8.2	8.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3558234	120832	None	0	Human	Binding	pKi	=	8.2	8.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	118710668	120832	None	0	Human	Binding	pKi	=	8.2	8.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3323283	120832	None	0	Human	Binding	pKi	=	8.2	8.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3558234	120832	None	0	Human	Binding	pKi	=	8.2	8.2	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	140844410	176390	None	0	Human	Binding	pKi	=	8.2	8.2	2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4436947	176390	None	0	Human	Binding	pKi	=	8.2	8.2	2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4595946	176390	None	0	Human	Binding	pKi	=	8.2	8.2	2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	71454562	79652	None	0	Human	Binding	pKi	=	8.2	8.2	6	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2115126	79652	None	0	Human	Binding	pKi	=	8.2	8.2	6	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	44431387	87316	None	0	Human	Binding	pKi	=	8.1	8.1	-1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL233201	87316	None	0	Human	Binding	pKi	=	8.1	8.1	-1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	164609510	188463	None	0	Human	Binding	pKi	=	8.1	8.1	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4846562	188463	None	0	Human	Binding	pKi	=	8.1	8.1	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5027965	188463	None	0	Human	Binding	pKi	=	8.1	8.1	2	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	10204457	204401	None	0	Human	Binding	pKi	=	8.1	8.1	-1	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	453	6	0	6	4.0	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL71971	204401	None	0	Human	Binding	pKi	=	8.1	8.1	-1	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	453	6	0	6	4.0	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	174174	523	None	49	Rat	Binding	pKi	=	8.1	8.1	-4	14	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	260	523	None	49	Rat	Binding	pKi	=	8.1	8.1	-4	14	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	320	523	None	49	Rat	Binding	pKi	=	8.1	8.1	-4	14	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	CHEMBL517712	523	None	49	Rat	Binding	pKi	=	8.1	8.1	-4	14	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	DB00572	523	None	49	Rat	Binding	pKi	=	8.1	8.1	-4	14	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	13567081	11232	None	0	Human	Binding	pKi	=	8.1	8.1	-6	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1178839	11232	None	0	Human	Binding	pKi	=	8.1	8.1	-6	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL45454	11232	None	0	Human	Binding	pKi	=	8.1	8.1	-6	5	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	44292563	187778	None	0	Rat	Binding	pKi	=	8.1	8.1	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
	CHEMBL49576	187778	None	0	Rat	Binding	pKi	=	8.1	8.1	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
	71449148	79536	None	0	Human	Binding	pKi	=	8.1	8.1	1	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2114064	79536	None	0	Human	Binding	pKi	=	8.1	8.1	1	4	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	155523889	176522	None	0	Human	Binding	pKi	=	8.1	8.1	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4454134	176522	None	0	Human	Binding	pKi	=	8.1	8.1	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597014	176522	None	0	Human	Binding	pKi	=	8.1	8.1	11	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	14939893	9532	None	0	Rat	Binding	pKi	=	8.1	8.1	-1	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL112244	9532	None	0	Rat	Binding	pKi	=	8.1	8.1	-1	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL5270925	193658	None	0	Human	Binding	pKi	=	8.1	8.1	-12	3	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	474	9	1	3	6.9	C#CCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	24846938	89799	None	0	Human	Binding	pKi	=	8.1	8.1	-6	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	8	1	5	3.4	CCN(CC)CCOC(=O)C(O)(c1cccs1)C1CCCCC1	10.1016/j.bmc.2013.01.072
	CHEMBL2377267	89799	None	0	Human	Binding	pKi	=	8.1	8.1	-6	4	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	8	1	5	3.4	CCN(CC)CCOC(=O)C(O)(c1cccs1)C1CCCCC1	10.1016/j.bmc.2013.01.072
	10030021	169877	None	12	Human	Binding	pKi	=	8.1	8.1	6	5	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	532	10	1	4	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4440484	169877	None	12	Human	Binding	pKi	=	8.1	8.1	6	5	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	532	10	1	4	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	9913341	82156	None	4	Human	Binding	pKi	=	8.1	8.1	-3	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL216927	82156	None	4	Human	Binding	pKi	=	8.1	8.1	-3	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL553058	82156	None	4	Human	Binding	pKi	=	8.1	8.1	-3	5	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	156014269	177214	None	0	Human	Binding	pKi	=	8.1	8.1	-10	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4635500	177214	None	0	Human	Binding	pKi	=	8.1	8.1	-10	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	44319071	206017	None	0	Human	Binding	pKi	=	8.1	8.1	-7	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL84993	206017	None	0	Human	Binding	pKi	=	8.1	8.1	-7	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	9913341	82156	None	4	Human	Binding	pKi	=	8.1	8.1	-3	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL216927	82156	None	4	Human	Binding	pKi	=	8.1	8.1	-3	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL553058	82156	None	4	Human	Binding	pKi	=	8.1	8.1	-3	5	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	9818955	9341	None	1	Rat	Binding	pKi	=	8.1	8.1	2	2	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	CHEMBL111224	9341	None	1	Rat	Binding	pKi	=	8.1	8.1	2	2	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	205895	11866	None	2	Rat	Binding	pKi	=	7.2	7.2	1	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	CHEMBL118240	11866	None	2	Rat	Binding	pKi	=	7.2	7.2	1	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	55005	104773	None	8	Rat	Binding	pKi	=	7.2	7.2	-1	3	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL310852	104773	None	8	Rat	Binding	pKi	=	7.2	7.2	-1	3	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	199230	163133	None	21	Rat	Binding	pKi	=	7.2	7.2	37	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	CHEMBL41779	163133	None	21	Rat	Binding	pKi	=	7.2	7.2	37	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	10262466	98342	None	0	Human	Binding	pKi	=	7.2	7.2	3	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/j.bmc.2007.09.003
	CHEMBL275104	98342	None	0	Human	Binding	pKi	=	7.2	7.2	3	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/j.bmc.2007.09.003
	10621363	121688	None	0	Human	Binding	pKi	=	7.2	7.2	-48	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
	CHEMBL358726	121688	None	0	Human	Binding	pKi	=	7.2	7.2	-48	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
	44593625	188128	None	0	Human	Binding	pKi	=	7.2	7.2	-5	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL498358	188128	None	0	Human	Binding	pKi	=	7.2	7.2	-5	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539120	188128	None	0	Human	Binding	pKi	=	7.2	7.2	-5	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	10449632	103444	None	0	Rat	Binding	pKi	=	6.2	6.2	-56	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	5	0	2	5.0	CCc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	CHEMBL3084898	103444	None	0	Rat	Binding	pKi	=	6.2	6.2	-56	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	5	0	2	5.0	CCc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	71458105	79594	None	0	Rat	Binding	pKi	=	5.2	5.2	-1	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL2114427	79594	None	0	Rat	Binding	pKi	=	5.2	5.2	-1	2	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	145962050	161630	None	0	Human	Binding	pKi	=	6.2	6.2	-3	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4130037	161630	None	0	Human	Binding	pKi	=	6.2	6.2	-3	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	10949838	5219	None	0	Human	Binding	pKi	=	6.2	6.2	-234	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.4	CCOC(=O)c1c(CC)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL106218	5219	None	0	Human	Binding	pKi	=	6.2	6.2	-234	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.4	CCOC(=O)c1c(CC)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	73346226	92262	None	0	Human	Binding	pKi	=	5.2	5.2	-1	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426668	92262	None	0	Human	Binding	pKi	=	5.2	5.2	-1	2	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
	164621361	188551	None	0	Human	Binding	pKi	=	5.2	5.2	-2	2	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4865137	188551	None	0	Human	Binding	pKi	=	5.2	5.2	-2	2	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028648	188551	None	0	Human	Binding	pKi	=	5.2	5.2	-2	2	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	14964498	13885	None	0	Rat	Binding	pKi	=	7.2	7.2	6	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119615	13885	None	0	Rat	Binding	pKi	=	7.2	7.2	6	2	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	10405613	202516	None	0	Human	Binding	pKi	=	7.2	7.2	1	2	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	350	2	1	4	3.0	CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1016/0960-894X(96)00107-2
	CHEMBL611476	202516	None	0	Human	Binding	pKi	=	7.2	7.2	1	2	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	350	2	1	4	3.0	CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1016/0960-894X(96)00107-2
	14964496	8962	None	0	Rat	Binding	pKi	=	6.2	6.2	1	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL109815	8962	None	0	Rat	Binding	pKi	=	6.2	6.2	1	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	10354969	13570	None	15	Rat	Binding	pKi	=	4.2	4.2	-4	2	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
	CHEMBL1194009	13570	None	15	Rat	Binding	pKi	=	4.2	4.2	-4	2	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
	CHEMBL545506	13570	None	15	Rat	Binding	pKi	=	4.2	4.2	-4	2	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
	1273	1752	None	16	Human	Binding	pKi	=	6.2	6.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	3450	1752	None	16	Human	Binding	pKi	=	6.2	6.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	356	1752	None	16	Human	Binding	pKi	=	6.2	6.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	6172	1752	None	16	Human	Binding	pKi	=	6.2	6.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	67425	1752	None	16	Human	Binding	pKi	=	6.2	6.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	CHEMBL360055	1752	None	16	Human	Binding	pKi	=	6.2	6.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	DB00483	1752	None	16	Human	Binding	pKi	=	6.2	6.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	10088338	103436	None	0	Rat	Binding	pKi	=	6.1	6.1	-15	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	4	0	2	5.0	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(C)cc2)cc1	10.1021/jm00020a006
	CHEMBL3084888	103436	None	0	Rat	Binding	pKi	=	6.1	6.1	-15	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	4	0	2	5.0	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(C)cc2)cc1	10.1021/jm00020a006
	44400375	69172	None	0	Rat	Binding	pKi	=	7.1	7.1	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	367	5	1	4	3.0	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL192537	69172	None	0	Rat	Binding	pKi	=	7.1	7.1	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	367	5	1	4	3.0	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
	11767229	78915	None	0	Human	Binding	pKi	=	7.1	7.1	-72	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	607	15	2	3	7.5	O=C(CCCCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL2112956	78915	None	0	Human	Binding	pKi	=	7.1	7.1	-72	5	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	607	15	2	3	7.5	O=C(CCCCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	9308	17752	None	21	Human	Binding	pKi	=	7.1	7.1	2	7	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL1255785	17752	None	21	Human	Binding	pKi	=	7.1	7.1	2	7	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL12587	17752	None	21	Human	Binding	pKi	=	7.1	7.1	2	7	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL292911	17752	None	21	Human	Binding	pKi	=	7.1	7.1	2	7	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	57339144	92236	None	78	Human	Binding	pKi	=	7.1	7.1	1	6	Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2	ChEMBL	529	6	1	5	4.8	O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Nc2ccccc2)c1)N1CCC(N2CCCC2)CC1	10.6019/CHEMBL5212743
	CHEMBL2426364	92236	None	78	Human	Binding	pKi	=	7.1	7.1	1	6	Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2	ChEMBL	529	6	1	5	4.8	O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Nc2ccccc2)c1)N1CCC(N2CCCC2)CC1	10.6019/CHEMBL5212743
	3652	4095	None	79	Human	Binding	pKi	=	6.1	6.1	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4095	None	79	Human	Binding	pKi	=	6.1	6.1	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4095	None	79	Human	Binding	pKi	=	6.1	6.1	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	6.1	6.1	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4095	None	79	Human	Binding	pKi	=	6.1	6.1	-18	18	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	162353391	180819	None	0	Human	Binding	pKi	=	5.1	5.1	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	CHEMBL4756873	180819	None	0	Human	Binding	pKi	=	5.1	5.1	1	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	44448606	11916	None	0	Human	Binding	pKi	=	5.1	5.1	-12	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182652	11916	None	0	Human	Binding	pKi	=	5.1	5.1	-12	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL258385	11916	None	0	Human	Binding	pKi	=	5.1	5.1	-12	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	10114698	4831	None	0	Human	Binding	pKi	=	5.1	5.1	-660	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	448	7	1	5	5.5	CCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL104210	4831	None	0	Human	Binding	pKi	=	5.1	5.1	-660	5	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	448	7	1	5	5.5	CCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	46227481	14137	None	0	Human	Binding	pKi	=	4.1	4.1	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL1198081	14137	None	0	Human	Binding	pKi	=	4.1	4.1	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL595022	14137	None	0	Human	Binding	pKi	=	4.1	4.1	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	16086001	139212	None	0	Human	Binding	pKi	=	7.1	7.1	-426	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	716	11	2	5	5.0	O=C(NCC1CCN(CC2CC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL378772	139212	None	0	Human	Binding	pKi	=	7.1	7.1	-426	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	716	11	2	5	5.0	O=C(NCC1CCN(CC2CC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	16125373	84788	None	0	Human	Binding	pKi	=	7.1	7.1	-28	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	2	5.2	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL223267	84788	None	0	Human	Binding	pKi	=	7.1	7.1	-28	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	2	5.2	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	44318930	106170	None	0	Human	Binding	pKi	=	6.1	6.1	-2	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
	CHEMBL313738	106170	None	0	Human	Binding	pKi	=	6.1	6.1	-2	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
	16086000	80354	None	0	Human	Binding	pKi	=	6.1	6.1	-1412	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	9	2	5	4.2	CN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
	CHEMBL214342	80354	None	0	Human	Binding	pKi	=	6.1	6.1	-1412	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	9	2	5	4.2	CN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
	9802631	111995	None	1	Rat	Binding	pKi	=	5.1	5.1	-3467	5	Compound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assayCompound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay	ChEMBL	427	7	2	4	3.7	COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm9601720
	CHEMBL328866	111995	None	1	Rat	Binding	pKi	=	5.1	5.1	-3467	5	Compound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assayCompound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay	ChEMBL	427	7	2	4	3.7	COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm9601720
	130442480	175268	None	0	Human	Binding	pKi	=	5.1	5.1	-89	24	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	175268	None	0	Human	Binding	pKi	=	5.1	5.1	-89	24	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	44400762	70566	None	0	Rat	Binding	pKi	=	6.1	6.1	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	396	5	2	3	2.3	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
	CHEMBL194870	70566	None	0	Rat	Binding	pKi	=	6.1	6.1	-2	2	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	396	5	2	3	2.3	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
	3028236	102597	None	1	Human	Binding	pKi	=	6.1	6.1	-1380	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL2377383	102597	None	1	Human	Binding	pKi	=	6.1	6.1	-1380	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL3041159	102597	None	1	Human	Binding	pKi	=	6.1	6.1	-1380	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	10336882	103446	None	0	Rat	Binding	pKi	=	7.1	7.1	-10	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	332	4	0	3	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C#N)cc1)C2	10.1021/jm00020a006
	CHEMBL3084900	103446	None	0	Rat	Binding	pKi	=	7.1	7.1	-10	2	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	332	4	0	3	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C#N)cc1)C2	10.1021/jm00020a006
	939078	63067	None	2	Rat	Binding	pKi	=	7.1	7.1	-12	2	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	CHEMBL1788286	63067	None	2	Rat	Binding	pKi	=	7.1	7.1	-12	2	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	44313626	204566	None	0	Human	Binding	pKi	=	7.1	7.1	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	399	7	0	4	4.8	O=C(OCOCCN1CCCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	CHEMBL73017	204566	None	0	Human	Binding	pKi	=	7.1	7.1	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	399	7	0	4	4.8	O=C(OCOCCN1CCCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	164611347	188472	None	0	Human	Binding	pKi	=	7.1	7.1	14	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4856090	188472	None	0	Human	Binding	pKi	=	7.1	7.1	14	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028070	188472	None	0	Human	Binding	pKi	=	7.1	7.1	14	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44576913	193312	None	0	Human	Binding	pKi	=	7.1	7.1	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL524186	193312	None	0	Human	Binding	pKi	=	7.1	7.1	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL557808	193312	None	0	Human	Binding	pKi	=	7.1	7.1	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	44274441	99091	None	0	Human	Binding	pKi	=	5.1	5.1	1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL280684	99091	None	0	Human	Binding	pKi	=	5.1	5.1	1	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	24894625	9776	None	0	Human	Binding	pKi	=	5.1	5.1	2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
	CHEMBL113580	9776	None	0	Human	Binding	pKi	=	5.1	5.1	2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
	CHEMBL553155	9776	None	0	Human	Binding	pKi	=	5.1	5.1	2	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
	156014813	178282	None	0	Human	Binding	pKi	=	5.1	5.1	-1	3	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4649668	178282	None	0	Human	Binding	pKi	=	5.1	5.1	-1	3	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650897	178282	None	0	Human	Binding	pKi	=	5.1	5.1	-1	3	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	5282593	55256	None	26	Human	Binding	pKi	=	7.1	7.1	-5	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	CHEMBL1319362	55256	None	26	Human	Binding	pKi	=	7.1	7.1	-5	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	CHEMBL1618018	55256	None	26	Human	Binding	pKi	=	7.1	7.1	-5	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	9308	17752	None	21	Rat	Binding	pKi	=	7.1	7.1	-2	7	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17752	None	21	Rat	Binding	pKi	=	7.1	7.1	-2	7	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17752	None	21	Rat	Binding	pKi	=	7.1	7.1	-2	7	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17752	None	21	Rat	Binding	pKi	=	7.1	7.1	-2	7	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	9308	17752	None	21	Human	Binding	pKi	=	7.1	7.1	2	7	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17752	None	21	Human	Binding	pKi	=	7.1	7.1	2	7	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17752	None	21	Human	Binding	pKi	=	7.1	7.1	2	7	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17752	None	21	Human	Binding	pKi	=	7.1	7.1	2	7	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	11504244	106517	None	0	Human	Binding	pKi	=	7.1	7.1	199	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	60138185	106517	None	0	Human	Binding	pKi	=	7.1	7.1	199	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3121474	106517	None	0	Human	Binding	pKi	=	7.1	7.1	199	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3140249	106517	None	0	Human	Binding	pKi	=	7.1	7.1	199	2	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	164623530	188571	None	0	Human	Binding	pKi	=	7.1	7.1	61	2	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4872632	188571	None	0	Human	Binding	pKi	=	7.1	7.1	61	2	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028763	188571	None	0	Human	Binding	pKi	=	7.1	7.1	61	2	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	2750	204059	None	76	Human	Binding	pKi	=	5.1	5.1	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	CHEMBL7002	204059	None	76	Human	Binding	pKi	=	5.1	5.1	-4	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	44627958	14034	None	0	Human	Binding	pKi	=	6.1	6.1	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197374	14034	None	0	Human	Binding	pKi	=	6.1	6.1	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569089	14034	None	0	Human	Binding	pKi	=	6.1	6.1	-2	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	11718570	72200	None	0	Rat	Binding	pKi	=	7.1	7.1	-9	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	376	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1Cc1ccccc1	10.1021/jm050099q
	CHEMBL198065	72200	None	0	Rat	Binding	pKi	=	7.1	7.1	-9	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	376	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1Cc1ccccc1	10.1021/jm050099q
	456292	96747	None	1	Human	Binding	pKi	=	6.1	6.1	-42	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	553	6	0	5	6.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL264442	96747	None	1	Human	Binding	pKi	=	6.1	6.1	-42	2	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	553	6	0	5	6.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	44309153	203512	None	0	Human	Binding	pKi	=	6.1	6.1	-69	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	4	2	3	2.5	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL66322	203512	None	0	Human	Binding	pKi	=	6.1	6.1	-69	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	4	2	3	2.5	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	44378888	56843	None	0	Human	Binding	pKi	=	7.1	7.1	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	0	8	4.3	Cc1cccnc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL164385	56843	None	0	Human	Binding	pKi	=	7.1	7.1	-	1	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	0	8	4.3	Cc1cccnc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	44593626	187851	None	0	Human	Binding	pKi	=	7.1	7.1	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496306	187851	None	0	Human	Binding	pKi	=	7.1	7.1	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539121	187851	None	0	Human	Binding	pKi	=	7.1	7.1	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	4212	198677	None	82	Human	Binding	pKi	=	7.1	7.1	1	4	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	CHEMBL1417019	198677	None	82	Human	Binding	pKi	=	7.1	7.1	1	4	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	CHEMBL58	198677	None	82	Human	Binding	pKi	=	7.1	7.1	1	4	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	75201901	166423	None	19	Human	Binding	pKi	=	5.1	5.1	-575	24	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	166423	None	19	Human	Binding	pKi	=	5.1	5.1	-575	24	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	71720489	86957	None	0	Rat	Binding	pKi	=	4.1	4.1	-1	2	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323447	86957	None	0	Rat	Binding	pKi	=	4.1	4.1	-1	2	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	11588241	155737	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL2092735	155737	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL405612	155737	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	45266385	195490	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	CHEMBL553241	195490	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	7047822	176834	None	15	Human	Binding	pKi	=	4.1	4.1	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc([C@H]2CCCN2)c1	10.1021/jm800145d
	CHEMBL461088	176834	None	15	Human	Binding	pKi	=	4.1	4.1	-3	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc([C@H]2CCCN2)c1	10.1021/jm800145d
	10026270	94113	None	0	Rat	Binding	pKi	=	6.1	6.1	-18	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	440	6	2	3	4.5	O=C(N[C@H]1[C@@H]2CN(Cc3ccc4ccccc4c3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL249206	94113	None	0	Rat	Binding	pKi	=	6.1	6.1	-18	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	440	6	2	3	4.5	O=C(N[C@H]1[C@@H]2CN(Cc3ccc4ccccc4c3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	44295668	188953	None	0	Human	Binding	pKi	=	7.1	7.1	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	462	6	2	4	4.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4N)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL50822	188953	None	0	Human	Binding	pKi	=	7.1	7.1	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	462	6	2	4	4.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4N)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	10336644	161671	None	0	Rat	Binding	pKi	=	5.1	5.1	1	2	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	328	3	1	3	3.4	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCC1	10.1021/jm970333f
	CHEMBL41313	161671	None	0	Rat	Binding	pKi	=	5.1	5.1	1	2	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	328	3	1	3	3.4	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCC1	10.1021/jm970333f
	14956860	13700	None	1	Rat	Binding	pKi	=	5.1	5.1	-1	2	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	CHEMBL1194903	13700	None	1	Rat	Binding	pKi	=	5.1	5.1	-1	2	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	CHEMBL553520	13700	None	1	Rat	Binding	pKi	=	5.1	5.1	-1	2	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	44406480	72842	None	0	Human	Binding	pKi	=	7.1	7.1	-5	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200210	72842	None	0	Human	Binding	pKi	=	7.1	7.1	-5	2	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10834711	121408	None	0	Human	Binding	pKi	=	7.1	7.1	-21	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	4	3.9	O=C(NC1CCN(Cc2ccsc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL358193	121408	None	0	Human	Binding	pKi	=	7.1	7.1	-21	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	4	3.9	O=C(NC1CCN(Cc2ccsc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	155551903	176455	None	0	Human	Binding	pKi	=	7.1	7.1	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4569929	176455	None	0	Human	Binding	pKi	=	7.1	7.1	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596435	176455	None	0	Human	Binding	pKi	=	7.1	7.1	1	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	118719931	115783	None	0	Human	Binding	pKi	=	7.1	7.1	-2	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	669	18	0	4	8.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)CC1	10.1021/jm501173q
	CHEMBL3354078	115783	None	0	Human	Binding	pKi	=	7.1	7.1	-2	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	669	18	0	4	8.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)CC1	10.1021/jm501173q
	44319339	205905	None	0	Human	Binding	pKi	=	7.1	7.1	-44	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83982	205905	None	0	Human	Binding	pKi	=	7.1	7.1	-44	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	137631026	161148	None	0	Human	Binding	pKi	=	6.1	6.1	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4093215	161148	None	0	Human	Binding	pKi	=	6.1	6.1	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117321	161148	None	0	Human	Binding	pKi	=	6.1	6.1	-2	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	2200	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
	328	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
	4848	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
	DB00670	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
	12310489	208392	None	0	Rat	Binding	pKi	=	6.1	6.1	1	2	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@H]3[C@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00566-8
	CHEMBL99618	208392	None	0	Rat	Binding	pKi	=	6.1	6.1	1	2	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@H]3[C@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00566-8
	2200	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
	328	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
	4848	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
	DB00670	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
	137640201	156959	None	2	Human	Binding	pKi	=	6.1	6.1	-630	13	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	362	6	0	2	4.3	O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4072818	156959	None	2	Human	Binding	pKi	=	6.1	6.1	-630	13	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	362	6	0	2	4.3	O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	42853213	104342	None	7	Human	Binding	pKi	=	6.1	6.1	-7	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	360	5	0	3	4.6	O=C(c1ccco1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL310016	104342	None	7	Human	Binding	pKi	=	6.1	6.1	-7	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	360	5	0	3	4.6	O=C(c1ccco1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	2396803	206124	None	3	Human	Binding	pKi	=	6.1	6.1	-10	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	398	7	0	2	5.3	O=C(CCc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85950	206124	None	3	Human	Binding	pKi	=	6.1	6.1	-10	2	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	398	7	0	2	5.3	O=C(CCc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	2200	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
	328	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
	4848	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
	DB00670	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
	2200	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
	328	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
	4848	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
	DB00670	3129	None	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
	9818955	9341	None	1	Rat	Binding	pKi	=	6.1	6.1	2	2	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	CHEMBL111224	9341	None	1	Rat	Binding	pKi	=	6.1	6.1	2	2	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	2736067	87528	None	73	Human	Binding	pKi	=	5.1	5.1	-93	5	Displacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysis	ChEMBL	230	1	1	2	2.4	Clc1cc(Cl)cc(N2CCNCC2)c1	10.1021/jm400140q
	CHEMBL2335158	87528	None	73	Human	Binding	pKi	=	5.1	5.1	-93	5	Displacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysis	ChEMBL	230	1	1	2	2.4	Clc1cc(Cl)cc(N2CCNCC2)c1	10.1021/jm400140q
	57326239	77180	None	0	Human	Binding	pKi	=	4.1	4.1	-5	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042551	77180	None	0	Human	Binding	pKi	=	4.1	4.1	-5	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2078974	77180	None	0	Human	Binding	pKi	=	4.1	4.1	-5	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	2551	793	None	23	Mouse	Binding	pKi	=	8.1	8.1	-8	11	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	298	793	None	23	Mouse	Binding	pKi	=	8.1	8.1	-8	11	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	488	793	None	23	Mouse	Binding	pKi	=	8.1	8.1	-8	11	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	CHEMBL965	793	None	23	Mouse	Binding	pKi	=	8.1	8.1	-8	11	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	DB00411	793	None	23	Mouse	Binding	pKi	=	8.1	8.1	-8	11	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	350	3554	None	7	Human	Binding	pKi	=	8.1	8.1	26	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
	9867750	3554	None	7	Human	Binding	pKi	=	8.1	8.1	26	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
	CHEMBL73341	3554	None	7	Human	Binding	pKi	=	8.1	8.1	26	2	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
	2028	2977	None	80	Human	Binding	pKi	=	8.1	8.1	-8	11	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
	359	2977	None	80	Human	Binding	pKi	=	8.1	8.1	-8	11	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
	4634	2977	None	80	Human	Binding	pKi	=	8.1	8.1	-8	11	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
	CHEMBL1231	2977	None	80	Human	Binding	pKi	=	8.1	8.1	-8	11	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
	DB01062	2977	None	80	Human	Binding	pKi	=	8.1	8.1	-8	11	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
	164619081	188535	None	0	Human	Binding	pKi	=	8.1	8.1	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4872720	188535	None	0	Human	Binding	pKi	=	8.1	8.1	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028531	188535	None	0	Human	Binding	pKi	=	8.1	8.1	4	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	118710668	120832	None	0	Human	Binding	pKi	=	8.1	8.1	1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3323283	120832	None	0	Human	Binding	pKi	=	8.1	8.1	1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3558234	120832	None	0	Human	Binding	pKi	=	8.1	8.1	1	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	3652	4095	None	79	Human	Binding	pKi	=	8.1	8.1	-18	18	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
	57	4095	None	79	Human	Binding	pKi	=	8.1	8.1	-18	18	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
	60809	4095	None	79	Human	Binding	pKi	=	8.1	8.1	-18	18	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	8.1	8.1	-18	18	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
	DB15357	4095	None	79	Human	Binding	pKi	=	8.1	8.1	-18	18	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
	118710664	120830	None	0	Human	Binding	pKi	=	8.1	8.1	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323281	120830	None	0	Human	Binding	pKi	=	8.1	8.1	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558231	120830	None	0	Human	Binding	pKi	=	8.1	8.1	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	10963509	18494	None	1	Human	Binding	pKi	=	8.1	8.1	1	5	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	687	17	0	6	8.6	COc1ccccc1CN1CCC(C2CCN(CCCCCCCCN3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
	CHEMBL127273	18494	None	1	Human	Binding	pKi	=	8.1	8.1	1	5	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	687	17	0	6	8.6	COc1ccccc1CN1CCC(C2CCN(CCCCCCCCN3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
	44267744	15446	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12153	15446	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	11155732	10545	None	17	Rat	Binding	pKi	=	8.1	8.1	-26	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL1169543	10545	None	17	Rat	Binding	pKi	=	8.1	8.1	-26	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	10104167	2057	None	2	Human	Binding	pKi	=	8.1	8.1	13	4	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	6937	2057	None	2	Human	Binding	pKi	=	8.1	8.1	13	4	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	CHEMBL3121473	2057	None	2	Human	Binding	pKi	=	8.1	8.1	13	4	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	44431386	149023	None	0	Human	Binding	pKi	=	8.1	8.1	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL394255	149023	None	0	Human	Binding	pKi	=	8.1	8.1	1	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	16125587	84761	None	0	Human	Binding	pKi	=	8.1	8.1	-5	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.6	C[N+]1(CCCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL223028	84761	None	0	Human	Binding	pKi	=	8.1	8.1	-5	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.6	C[N+]1(CCCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	118710670	120831	None	0	Human	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323284	120831	None	0	Human	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558233	120831	None	0	Human	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	55005	104773	None	8	Rat	Binding	pKi	=	7.1	7.1	-1	3	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL310852	104773	None	8	Rat	Binding	pKi	=	7.1	7.1	-1	3	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	14964496	8962	None	0	Rat	Binding	pKi	=	7.1	7.1	1	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL109815	8962	None	0	Rat	Binding	pKi	=	7.1	7.1	1	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL69452	203972	None	0	Human	Binding	pKi	=	7.1	7.1	2	5	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	331	6	1	5	2.7	CCO/C(O)=C1\CN2CC(CCC2COCc2ccccc2)C1=O	10.1021/jm020572p
	11718536	137843	None	0	Human	Binding	pKi	=	7.1	7.1	-41	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	411	5	1	2	4.6	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL376000	137843	None	0	Human	Binding	pKi	=	7.1	7.1	-41	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	411	5	1	2	4.6	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	574784	103593	None	2	Rat	Binding	pKi	=	5.1	5.1	-1	2	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	379	3	0	5	2.0	CCN1C(=O)c2ccccc2N(C(=O)CN2CCN(C)CC2)c2ncccc21	10.1021/jm00111a032
	CHEMBL308650	103593	None	2	Rat	Binding	pKi	=	5.1	5.1	-1	2	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	379	3	0	5	2.0	CCN1C(=O)c2ccccc2N(C(=O)CN2CCN(C)CC2)c2ncccc21	10.1021/jm00111a032
	10354968	13073	None	1	Rat	Binding	pKi	=	4.1	4.1	-1	2	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
	CHEMBL1190173	13073	None	1	Rat	Binding	pKi	=	4.1	4.1	-1	2	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
	CHEMBL540310	13073	None	1	Rat	Binding	pKi	=	4.1	4.1	-1	2	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
	107867	2972	None	55	Human	Binding	pKi	=	7.1	7.1	2	11	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
	309	2972	None	55	Human	Binding	pKi	=	7.1	7.1	2	11	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
	CHEMBL17045	2972	None	55	Human	Binding	pKi	=	7.1	7.1	2	11	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
	164614830	188498	None	0	Human	Binding	pKi	=	7.1	7.1	46	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4858774	188498	None	0	Human	Binding	pKi	=	7.1	7.1	46	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028275	188498	None	0	Human	Binding	pKi	=	7.1	7.1	46	3	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	130442572	171906	None	0	Human	Binding	pKi	=	5.1	5.1	-173	24	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171906	None	0	Human	Binding	pKi	=	5.1	5.1	-173	24	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	10365534	154958	None	0	Rat	Binding	pKi	=	6.1	6.1	-18	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	7	2	3	4.0	Cc1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1C	10.1016/j.bmcl.2007.06.081
	CHEMBL401154	154958	None	0	Rat	Binding	pKi	=	6.1	6.1	-18	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	7	2	3	4.0	Cc1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1C	10.1016/j.bmcl.2007.06.081
	11530307	78340	None	0	Human	Binding	pKi	=	4.1	4.1	1	2	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2093082	78340	None	0	Human	Binding	pKi	=	4.1	4.1	1	2	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2109993	78340	None	0	Human	Binding	pKi	=	4.1	4.1	1	2	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	45266386	194914	None	0	Human	Binding	pKi	=	4.1	4.1	1	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	CHEMBL541424	194914	None	0	Human	Binding	pKi	=	4.1	4.1	1	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	44286173	144485	None	0	Rat	Binding	pKi	=	6.1	6.1	3	2	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	194	3	0	2	0.6	CCN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL39068	144485	None	0	Rat	Binding	pKi	=	6.1	6.1	3	2	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	194	3	0	2	0.6	CCN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
	16125223	168897	None	0	Human	Binding	pKi	=	7.1	7.1	-6	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
	CHEMBL438427	168897	None	0	Human	Binding	pKi	=	7.1	7.1	-6	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
	44308900	203994	None	0	Human	Binding	pKi	=	6.1	6.1	-85	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	367	5	2	4	1.4	NCCN1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL69582	203994	None	0	Human	Binding	pKi	=	6.1	6.1	-85	3	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	367	5	2	4	1.4	NCCN1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	44318929	106860	None	0	Human	Binding	pKi	=	6.1	6.1	-2	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
	CHEMBL314493	106860	None	0	Human	Binding	pKi	=	6.1	6.1	-2	4	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
	CHEMBL5092328	215357	None	5	Human	Binding	pKi	=	5.1	5.1	-6	4	Displacement of [3H]-AF-DX 384 from human recombinant muscarinic 2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]-AF-DX 384 from human recombinant muscarinic 2 receptor after 60 mins by scintillation counting analysis	ChEMBL		None	None	None		CCS(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N	10.1021/acs.jmedchem.1c00935
	3236	67607	None	43	Human	Binding	pKi	=	6.1	6.1	1	2	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
	CHEMBL1902981	67607	None	43	Human	Binding	pKi	=	6.1	6.1	1	2	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
	36381	12940	None	5	Human	Binding	pKi	=	6.1	6.1	-2	6	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmcl.2012.08.046
	CHEMBL1189234	12940	None	5	Human	Binding	pKi	=	6.1	6.1	-2	6	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmcl.2012.08.046
	36381	12940	None	5	Human	Binding	pKi	=	6.1	6.1	-2	6	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmc.2013.07.045
	CHEMBL1189234	12940	None	5	Human	Binding	pKi	=	6.1	6.1	-2	6	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmc.2013.07.045
	302	2975	None	25	Rat	Binding	pKi	=	7.1	7.1	-4	8	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
	4630	2975	None	25	Rat	Binding	pKi	=	7.1	7.1	-4	8	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
	CHEMBL7634	2975	None	25	Rat	Binding	pKi	=	7.1	7.1	-4	8	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
	15050954	204001	None	0	Rat	Binding	pKi	=	6.1	6.1	2	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	524	6	1	7	2.6	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL69620	204001	None	0	Rat	Binding	pKi	=	6.1	6.1	2	2	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	524	6	1	7	2.6	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	71718048	86953	None	0	Rat	Binding	pKi	=	4.1	4.1	-1	2	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323443	86953	None	0	Rat	Binding	pKi	=	4.1	4.1	-1	2	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	9948957	204490	None	1	Human	Binding	pKi	=	6.1	6.1	1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	319	11	0	3	3.9	CCN(CC)CCOCCOCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL72506	204490	None	1	Human	Binding	pKi	=	6.1	6.1	1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	319	11	0	3	3.9	CCN(CC)CCOCCOCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	118719924	115776	None	0	Human	Binding	pKi	=	7.1	7.1	-5	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	649	20	0	7	8.4	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354071	115776	None	0	Human	Binding	pKi	=	7.1	7.1	-5	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	649	20	0	7	8.4	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	44593624	188127	None	0	Human	Binding	pKi	=	7.1	7.1	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL498357	188127	None	0	Human	Binding	pKi	=	7.1	7.1	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL554916	188127	None	0	Human	Binding	pKi	=	7.1	7.1	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	9842753	201810	None	0	Rat	Binding	pKi	=	6.1	6.1	-24	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@@H](O)c2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL606963	201810	None	0	Rat	Binding	pKi	=	6.1	6.1	-24	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@@H](O)c2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
	10101246	9544	None	0	Human	Binding	pKi	=	6.1	6.1	-81	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL112297	9544	None	0	Human	Binding	pKi	=	6.1	6.1	-81	2	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	44299564	199085	None	0	Human	Binding	pKi	=	6.1	6.1	-1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL58824	199085	None	0	Human	Binding	pKi	=	6.1	6.1	-1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	11759379	120775	None	0	Human	Binding	pKi	=	6.1	6.1	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	332	5	0	2	5.1	CC(C1=C(CCN2CCCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL355392	120775	None	0	Human	Binding	pKi	=	6.1	6.1	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	332	5	0	2	5.1	CC(C1=C(CCN2CCCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	167962	4067	None	4	Human	Binding	pKi	=	6.1	6.1	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4067	None	4	Human	Binding	pKi	=	6.1	6.1	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4067	None	4	Human	Binding	pKi	=	6.1	6.1	-	1	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	302	2975	None	25	Human	Binding	pKi	=	6.1	6.1	-34	8	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	4630	2975	None	25	Human	Binding	pKi	=	6.1	6.1	-34	8	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	CHEMBL7634	2975	None	25	Human	Binding	pKi	=	6.1	6.1	-34	8	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	123603	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
	2684	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
	584	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
	9658	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
	CHEMBL168815	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
	DB00185	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
	2398	953	None	62	Human	Binding	pKi	=	7.1	7.1	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	2801	953	None	62	Human	Binding	pKi	=	7.1	7.1	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	701	953	None	62	Human	Binding	pKi	=	7.1	7.1	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	CHEMBL415	953	None	62	Human	Binding	pKi	=	7.1	7.1	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	DB01242	953	None	62	Human	Binding	pKi	=	7.1	7.1	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	10574041	39820	None	0	Human	Binding	pKi	=	5.1	5.1	-281	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	418	6	2	4	3.7	O=C(NC1CCN(Cc2ccoc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL147695	39820	None	0	Human	Binding	pKi	=	5.1	5.1	-281	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	418	6	2	4	3.7	O=C(NC1CCN(Cc2ccoc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL308924	103785	None	0	Human	Binding	pKi	=	4.1	4.1	-2	2	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	268	4	1	5	1.0	CCO/C(O)=C1\CN2CC(CCC2CN(C)C)C1=O	10.1021/jm020572p
	71716225	86955	None	0	Rat	Binding	pKi	=	4.1	4.1	1	2	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323445	86955	None	0	Rat	Binding	pKi	=	4.1	4.1	1	2	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	16125325	84571	None	0	Human	Binding	pKi	=	6.1	6.1	-2	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	336	3	1	1	2.8	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222090	84571	None	0	Human	Binding	pKi	=	6.1	6.1	-2	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	336	3	1	1	2.8	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	2229	464	None	22	Human	Binding	pKi	=	7.1	7.1	1	6	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
	295	464	None	22	Human	Binding	pKi	=	7.1	7.1	1	6	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
	CHEMBL128365	464	None	22	Human	Binding	pKi	=	7.1	7.1	1	6	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
	44627956	14032	None	0	Human	Binding	pKi	=	7.1	7.1	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197362	14032	None	0	Human	Binding	pKi	=	7.1	7.1	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL568775	14032	None	0	Human	Binding	pKi	=	7.1	7.1	-1	5	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	1687	104407	None	20	Rat	Binding	pKi	=	7.1	7.1	-15	5	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	CHEMBL310310	104407	None	20	Rat	Binding	pKi	=	7.1	7.1	-15	5	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	CHEMBL540034	104407	None	20	Rat	Binding	pKi	=	7.1	7.1	-15	5	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	3072501	107267	None	6	Mouse	Binding	pKi	=	6.1	6.1	-	1	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL316973	107267	None	6	Mouse	Binding	pKi	=	6.1	6.1	-	1	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	53390181	92269	None	0	Human	Binding	pKi	=	6.1	6.1	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426675	92269	None	0	Human	Binding	pKi	=	6.1	6.1	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	53390538	92275	None	0	Human	Binding	pKi	=	6.1	6.1	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426681	92275	None	0	Human	Binding	pKi	=	6.1	6.1	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	44448421	12335	None	0	Human	Binding	pKi	=	6.1	6.1	-11	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL1185269	12335	None	0	Human	Binding	pKi	=	6.1	6.1	-11	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL403773	12335	None	0	Human	Binding	pKi	=	6.1	6.1	-11	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	156013387	178259	None	0	Human	Binding	pKi	=	6.1	6.1	-1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4638935	178259	None	0	Human	Binding	pKi	=	6.1	6.1	-1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650725	178259	None	0	Human	Binding	pKi	=	6.1	6.1	-1	5	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	156012563	178246	None	0	Human	Binding	pKi	=	5.1	5.1	-3	4	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4637485	178246	None	0	Human	Binding	pKi	=	5.1	5.1	-3	4	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650635	178246	None	0	Human	Binding	pKi	=	5.1	5.1	-3	4	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	156013998	178267	None	0	Human	Binding	pKi	=	5.1	5.1	-	1	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4635148	178267	None	0	Human	Binding	pKi	=	5.1	5.1	-	1	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650787	178267	None	0	Human	Binding	pKi	=	5.1	5.1	-	1	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	11672895	77803	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@H]1O[C@@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL2092737	77803	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@H]1O[C@@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
	71452384	83795	None	0	Human	Binding	pKi	=	6.1	6.1	-4	5	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205816	83795	None	0	Human	Binding	pKi	=	6.1	6.1	-4	5	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmcl.2012.08.046
	71452384	83795	None	0	Human	Binding	pKi	=	6.1	6.1	-4	5	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmc.2013.07.045
	CHEMBL2205816	83795	None	0	Human	Binding	pKi	=	6.1	6.1	-4	5	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmc.2013.07.045
	44437295	11891	None	0	Human	Binding	pKi	=	6.1	6.1	4	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
	CHEMBL1182472	11891	None	0	Human	Binding	pKi	=	6.1	6.1	4	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
	CHEMBL239866	11891	None	0	Human	Binding	pKi	=	6.1	6.1	4	5	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
	16125704	84662	None	0	Human	Binding	pKi	=	7.1	7.1	-54	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222450	84662	None	0	Human	Binding	pKi	=	7.1	7.1	-54	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	71720488	86951	None	0	Rat	Binding	pKi	=	5.1	5.1	-13	3	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323441	86951	None	0	Rat	Binding	pKi	=	5.1	5.1	-13	3	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	15050952	203494	None	0	Rat	Binding	pKi	=	5.1	5.1	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	507	9	3	7	1.0	CC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL66177	203494	None	0	Rat	Binding	pKi	=	5.1	5.1	1	3	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	507	9	3	7	1.0	CC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	16125531	84354	None	0	Human	Binding	pKi	=	6.1	6.1	-3	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL221775	84354	None	0	Human	Binding	pKi	=	6.1	6.1	-3	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	73355416	92535	None	0	Human	Binding	pKi	=	5.1	5.1	-1	2	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	0	3	1.8	CN(Cc1cccnc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432043	92535	None	0	Human	Binding	pKi	=	5.1	5.1	-1	2	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	0	3	1.8	CN(Cc1cccnc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	15050955	102596	None	0	Rat	Binding	pKi	=	7.1	7.1	1	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	538	7	1	7	3.0	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL304112	102596	None	0	Rat	Binding	pKi	=	7.1	7.1	1	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	538	7	1	7	3.0	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	164622017	188556	None	0	Human	Binding	pKi	=	7.1	7.1	47	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4871563	188556	None	0	Human	Binding	pKi	=	7.1	7.1	47	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028681	188556	None	0	Human	Binding	pKi	=	7.1	7.1	47	4	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	109014373	179800	None	1	Human	Binding	pKi	=	7.1	7.1	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4744856	179800	None	1	Human	Binding	pKi	=	7.1	7.1	3	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	118719923	115775	None	0	Human	Binding	pKi	=	7.1	7.1	-13	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	621	18	0	7	7.6	CN1CCC=C(c2nsnc2OCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354070	115775	None	0	Human	Binding	pKi	=	7.1	7.1	-13	5	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	621	18	0	7	7.6	CN1CCC=C(c2nsnc2OCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	14964498	13885	None	0	Rat	Binding	pKi	=	5.1	5.1	6	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119615	13885	None	0	Rat	Binding	pKi	=	5.1	5.1	6	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	11694119	115485	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@@H]1O[C@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL3351105	115485	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@@H]1O[C@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
	46227417	14126	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL1198048	14126	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL593864	14126	None	0	Human	Binding	pKi	=	4.1	4.1	-	1	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	44296096	101895	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	519	6	1	5	4.4	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL300845	101895	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	519	6	1	5	4.4	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	44295763	188813	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	CHEMBL50618	188813	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	44296006	189729	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5c(F)cccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL51574	189729	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5c(F)cccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	15407072	56864	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	471	5	1	7	3.1	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCNCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	CHEMBL164397	56864	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	471	5	1	7	3.1	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCNCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	9889312	78428	None	0	Human	Binding	pKi	=	8.1	8.1	2	5	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL2111540	78428	None	0	Human	Binding	pKi	=	8.1	8.1	2	5	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	44455198	97655	None	0	Human	Binding	pKi	=	8.1	8.1	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1016/j.bmcl.2007.11.022
	CHEMBL271108	97655	None	0	Human	Binding	pKi	=	8.1	8.1	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1016/j.bmcl.2007.11.022
	44455198	97655	None	0	Rat	Binding	pKi	=	8.1	8.1	-1	10	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1021/acs.jmedchem.8b00041
	CHEMBL271108	97655	None	0	Rat	Binding	pKi	=	8.1	8.1	-1	10	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1021/acs.jmedchem.8b00041
	44292834	101454	None	0	Rat	Binding	pKi	=	8.1	8.1	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
	CHEMBL297683	101454	None	0	Rat	Binding	pKi	=	8.1	8.1	-	1	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
	44325003	111640	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	618	8	0	8	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328550	111640	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	618	8	0	8	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	10865439	20623	None	0	Human	Binding	pKi	=	8.0	8.0	1	5	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	715	15	0	6	7.6	COc1ccccc1CN1CCC(C2CCN(C(=O)CCCCCCC(=O)N3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
	CHEMBL130835	20623	None	0	Human	Binding	pKi	=	8.0	8.0	1	5	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	715	15	0	6	7.6	COc1ccccc1CN1CCC(C2CCN(C(=O)CCCCCCC(=O)N3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
	140844398	176359	None	0	Human	Binding	pKi	=	8.0	8.0	2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4470924	176359	None	0	Human	Binding	pKi	=	8.0	8.0	2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4595692	176359	None	0	Human	Binding	pKi	=	8.0	8.0	2	2	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	71128	96808	None	25	Human	Binding	pKi	=	8.0	8.0	-17	8	Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00085a017
	CHEMBL26505	96808	None	25	Human	Binding	pKi	=	8.0	8.0	-17	8	Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00085a017
	CHEMBL5265833	193455	None	0	Human	Binding	pKi	=	8.0	8.0	-28	3	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	488	10	1	3	7.1	C#CCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	155543345	176684	None	0	Human	Binding	pKi	=	8.0	8.0	6	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4543584	176684	None	0	Human	Binding	pKi	=	8.0	8.0	6	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4598362	176684	None	0	Human	Binding	pKi	=	8.0	8.0	6	5	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	101720828	97118	None	0	Rat	Binding	pKi	=	8.0	8.0	1	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	16147087	97118	None	0	Rat	Binding	pKi	=	8.0	8.0	1	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202002	97118	None	0	Rat	Binding	pKi	=	8.0	8.0	1	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL267643	97118	None	0	Rat	Binding	pKi	=	8.0	8.0	1	5	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	4841	67425	None	5	Human	Binding	pKi	=	8.0	8.0	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	CHEMBL1889399	67425	None	5	Human	Binding	pKi	=	8.0	8.0	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	CHEMBL1909073	67425	None	5	Human	Binding	pKi	=	8.0	8.0	-1	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	11968014	12756	None	5	Human	Binding	pKi	=	8.0	8.0	-4	9	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm301774u
	119680147	12756	None	5	Human	Binding	pKi	=	8.0	8.0	-4	9	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm301774u
	CHEMBL1187846	12756	None	5	Human	Binding	pKi	=	8.0	8.0	-4	9	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm301774u
	DB00747	12756	None	5	Human	Binding	pKi	=	8.0	8.0	-4	9	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm301774u
	10302719	43506	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	548	5	0	4	6.3	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
	CHEMBL150845	43506	None	0	Human	Binding	pKi	=	8.0	8.0	-	1	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	548	5	0	4	6.3	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
	CHEMBL5271406	193679	None	0	Human	Binding	pKi	=	8.0	8.0	-10	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1159	27	3	10	12.8	CC1(C)C(/C=C/C=C/C=C2/N(CCCCS(=O)(=O)O)c3ccccc3C2(C)C)=[N+](CCCCCC(=O)NCCCCCCCCN2CCC(OC(=O)Nc3ccc(F)cc3-c3ccc(F)c(Cl)c3)CC2)c2ccc(S(=O)(=O)[O-])cc21	10.1021/acs.jmedchem.2c01376
	2028	2977	None	80	Human	Binding	pKi	=	8.0	8.0	-8	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	359	2977	None	80	Human	Binding	pKi	=	8.0	8.0	-8	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	4634	2977	None	80	Human	Binding	pKi	=	8.0	8.0	-8	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	CHEMBL1231	2977	None	80	Human	Binding	pKi	=	8.0	8.0	-8	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	DB01062	2977	None	80	Human	Binding	pKi	=	8.0	8.0	-8	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	118710662	120828	None	0	Human	Binding	pKi	=	8.0	8.0	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323280	120828	None	0	Human	Binding	pKi	=	8.0	8.0	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558229	120828	None	0	Human	Binding	pKi	=	8.0	8.0	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	118710662	120828	None	0	Human	Binding	pKi	=	8.0	8.0	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323280	120828	None	0	Human	Binding	pKi	=	8.0	8.0	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558229	120828	None	0	Human	Binding	pKi	=	8.0	8.0	1	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	57326326	77176	None	0	Human	Binding	pKi	=	8.0	8.0	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042553	77176	None	0	Human	Binding	pKi	=	8.0	8.0	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2078942	77176	None	0	Human	Binding	pKi	=	8.0	8.0	-7	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	57326326	77176	None	0	Human	Binding	pKi	=	8.0	8.0	-7	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL2042553	77176	None	0	Human	Binding	pKi	=	8.0	8.0	-7	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL2078942	77176	None	0	Human	Binding	pKi	=	8.0	8.0	-7	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL5267836	193536	None	0	Human	Binding	pKi	=	8.0	8.0	-4	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1038	20	1	13	9.8	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
	CHEMBL5289083	194456	None	0	Human	Binding	pKi	=	8	8.0	-5	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1002	24	3	6	13.3	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCNCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
	16125591	84696	None	0	Human	Binding	pKi	=	8	8.0	-1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	455	6	2	2	3.8	C[N+]1(CC(=O)Nc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222634	84696	None	0	Human	Binding	pKi	=	8	8.0	-1	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	455	6	2	2	3.8	C[N+]1(CC(=O)Nc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	14964494	11955	None	1	Rat	Binding	pKi	=	7.1	7.1	2	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118292	11955	None	1	Rat	Binding	pKi	=	7.1	7.1	2	2	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	155672	5035	None	3	Rat	Binding	pKi	=	7.1	7.1	7	3	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL105198	5035	None	3	Rat	Binding	pKi	=	7.1	7.1	7	3	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL56734	5035	None	3	Rat	Binding	pKi	=	7.1	7.1	7	3	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	44431367	87980	None	0	Human	Binding	pKi	=	7.1	7.1	-4	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234252	87980	None	0	Human	Binding	pKi	=	7.1	7.1	-4	3	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	44318766	205749	None	0	Human	Binding	pKi	=	5.1	5.1	-4	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
	CHEMBL82754	205749	None	0	Human	Binding	pKi	=	5.1	5.1	-4	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
	16124710	85183	None	0	Human	Binding	pKi	=	6.0	6.0	-54	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	0	3	5.0	O=C1OC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL225387	85183	None	0	Human	Binding	pKi	=	6.0	6.0	-54	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	0	3	5.0	O=C1OC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	60138186	120834	None	0	Human	Binding	pKi	=	7.0	7.0	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	60138193	120834	None	0	Human	Binding	pKi	=	7.0	7.0	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323288	120834	None	0	Human	Binding	pKi	=	7.0	7.0	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558240	120834	None	0	Human	Binding	pKi	=	7.0	7.0	23	2	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	11504244	106517	None	0	Human	Binding	pKi	=	7.0	7.0	199	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	60138185	106517	None	0	Human	Binding	pKi	=	7.0	7.0	199	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3121474	106517	None	0	Human	Binding	pKi	=	7.0	7.0	199	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3140249	106517	None	0	Human	Binding	pKi	=	7.0	7.0	199	2	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	303	2976	None	17	Rat	Binding	pKi	=	6.0	6.0	1	6	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	4629	2976	None	17	Rat	Binding	pKi	=	6.0	6.0	1	6	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	8595	2976	None	17	Rat	Binding	pKi	=	6.0	6.0	1	6	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL44674	2976	None	17	Rat	Binding	pKi	=	6.0	6.0	1	6	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	170332	160974	None	1	Human	Binding	pKi	=	5.0	5.0	3	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Binding	pKi	=	5.0	5.0	3	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Binding	pKi	=	5.0	5.0	3	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	11024241	120299	None	0	Human	Binding	pKi	=	6.0	6.0	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	338	6	0	3	4.9	CSc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	CHEMBL352723	120299	None	0	Human	Binding	pKi	=	6.0	6.0	-1	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	338	6	0	3	4.9	CSc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	73346227	92267	None	0	Human	Binding	pKi	=	6.0	6.0	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426673	92267	None	0	Human	Binding	pKi	=	6.0	6.0	-	1	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	162353382	181732	None	0	Human	Binding	pKi	=	6.0	6.0	4	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	CHEMBL4777127	181732	None	0	Human	Binding	pKi	=	6.0	6.0	4	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	44274417	98892	None	0	Human	Binding	pKi	=	5.0	5.0	2	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL279225	98892	None	0	Human	Binding	pKi	=	5.0	5.0	2	5	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	57664406	2396	None	50	Human	Binding	pKi	=	5.0	5.0	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	6938	2396	None	50	Human	Binding	pKi	=	5.0	5.0	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089376	2396	None	50	Human	Binding	pKi	=	5.0	5.0	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	170332	160974	None	1	Human	Binding	pKi	=	5.0	5.0	3	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160974	None	1	Human	Binding	pKi	=	5.0	5.0	3	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160974	None	1	Human	Binding	pKi	=	5.0	5.0	3	3	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	3158	56265	None	27	Human	Binding	pKi	=	7.0	7.0	-630	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL1628227	56265	None	27	Human	Binding	pKi	=	7.0	7.0	-630	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	DB01142	56265	None	27	Human	Binding	pKi	=	7.0	7.0	-630	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL5274390	193811	None	0	Human	Binding	pKi	=	7.0	7.0	-32	3	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	366	3	2	3	4.6	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OC1CCNCC1	10.1021/acs.jmedchem.2c01376
	44318929	106860	None	0	Human	Binding	pKi	=	6.0	6.0	-2	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
	CHEMBL314493	106860	None	0	Human	Binding	pKi	=	6.0	6.0	-2	4	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
	10105880	37449	None	0	Human	Binding	pKi	=	5.0	5.0	-5	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	1	4	1.7	OC1(c2nc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL145533	37449	None	0	Human	Binding	pKi	=	5.0	5.0	-5	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	1	4	1.7	OC1(c2nc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
	137628800	160992	None	0	Human	Binding	pKi	=	5.0	5.0	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4089027	160992	None	0	Human	Binding	pKi	=	5.0	5.0	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116151	160992	None	0	Human	Binding	pKi	=	5.0	5.0	-1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
	44267699	13673	None	0	Human	Binding	pKi	=	6.0	6.0	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	426	6	0	4	5.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccco4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11947	13673	None	0	Human	Binding	pKi	=	6.0	6.0	-	1	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	426	6	0	4	5.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccco4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	199230	163133	None	21	Rat	Binding	pKi	=	6.0	6.0	37	2	Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL41779	163133	None	21	Rat	Binding	pKi	=	6.0	6.0	37	2	Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
	16125509	169340	None	0	Human	Binding	pKi	=	6.0	6.0	-69	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	3	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccs2)CC1	10.1021/jm061159a
	CHEMBL441873	169340	None	0	Human	Binding	pKi	=	6.0	6.0	-69	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	3	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccs2)CC1	10.1021/jm061159a
	11501540	133601	None	0	Rat	Binding	pKi	=	7.0	7.0	-16	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
	CHEMBL371293	133601	None	0	Rat	Binding	pKi	=	7.0	7.0	-16	3	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
	137628788	160990	None	0	Human	Binding	pKi	=	6.0	6.0	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4085150	160990	None	0	Human	Binding	pKi	=	6.0	6.0	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116149	160990	None	0	Human	Binding	pKi	=	6.0	6.0	1	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	10670961	40630	None	0	Human	Binding	pKi	=	6.0	6.0	-66	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)nc1	10.1021/jm0003135
	CHEMBL148404	40630	None	0	Human	Binding	pKi	=	6.0	6.0	-66	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)nc1	10.1021/jm0003135
	14964498	13885	None	0	Rat	Binding	pKi	=	5.0	5.0	6	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119615	13885	None	0	Rat	Binding	pKi	=	5.0	5.0	6	2	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	191	403	None	98	Human	Binding	pKi	=	6.0	6.0	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	201	403	None	98	Human	Binding	pKi	=	6.0	6.0	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2170	403	None	98	Human	Binding	pKi	=	6.0	6.0	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	CHEMBL1113	403	None	98	Human	Binding	pKi	=	6.0	6.0	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	DB00543	403	None	98	Human	Binding	pKi	=	6.0	6.0	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	44275807	98968	None	0	Human	Binding	pKi	=	6.0	6.0	-851	10	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
	CHEMBL27979	98968	None	0	Human	Binding	pKi	=	6.0	6.0	-851	10	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
	11653112	78331	None	0	Human	Binding	pKi	=	5.0	5.0	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2092820	78331	None	0	Human	Binding	pKi	=	5.0	5.0	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2109828	78331	None	0	Human	Binding	pKi	=	5.0	5.0	-	1	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	45266386	194914	None	0	Human	Binding	pKi	=	5.0	5.0	1	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	CHEMBL541424	194914	None	0	Human	Binding	pKi	=	5.0	5.0	1	3	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	57664406	2396	None	50	Human	Binding	pKi	=	5.0	5.0	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	6938	2396	None	50	Human	Binding	pKi	=	5.0	5.0	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089376	2396	None	50	Human	Binding	pKi	=	5.0	5.0	-1	2	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	11110049	58238	None	0	Human	Binding	pKi	=	4.0	4.0	-2	4	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL168223	58238	None	0	Human	Binding	pKi	=	4.0	4.0	-2	4	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
	13773340	79588	None	0	Rat	Binding	pKi	=	6.0	6.0	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2114396	79588	None	0	Rat	Binding	pKi	=	6.0	6.0	-	1	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	3823	50219	None	42	Human	Binding	pKi	=	5.0	5.0	-44	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	76973198	50219	None	42	Human	Binding	pKi	=	5.0	5.0	-44	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	CHEMBL157101	50219	None	42	Human	Binding	pKi	=	5.0	5.0	-44	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	16086005	139229	None	0	Human	Binding	pKi	=	7.0	7.0	-77	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	724	10	3	5	5.8	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	CHEMBL378859	139229	None	0	Human	Binding	pKi	=	7.0	7.0	-77	5	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	724	10	3	5	5.8	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	16125646	136969	None	0	Human	Binding	pKi	=	7.0	7.0	-50	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	476	6	1	2	4.3	C[N+]1(CC(=O)c2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL374513	136969	None	0	Human	Binding	pKi	=	7.0	7.0	-50	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	476	6	1	2	4.3	C[N+]1(CC(=O)c2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	10598540	38327	None	0	Human	Binding	pKi	=	5.0	5.0	-134	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	426	6	2	3	5.0	O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL146291	38327	None	0	Human	Binding	pKi	=	5.0	5.0	-134	3	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	426	6	2	3	5.0	O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	44443722	154918	None	0	Rat	Binding	pKi	=	6.0	6.0	-29	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL400953	154918	None	0	Rat	Binding	pKi	=	6.0	6.0	-29	2	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.06.081
	10360219	102008	None	0	Human	Binding	pKi	=	7.0	7.0	1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL301670	102008	None	0	Human	Binding	pKi	=	7.0	7.0	1	4	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	57326325	77182	None	0	Human	Binding	pKi	=	7.0	7.0	-2	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042554	77182	None	0	Human	Binding	pKi	=	7.0	7.0	-2	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2078987	77182	None	0	Human	Binding	pKi	=	7.0	7.0	-2	5	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	44593624	188127	None	0	Human	Binding	pKi	=	7.0	7.0	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL498357	188127	None	0	Human	Binding	pKi	=	7.0	7.0	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL554916	188127	None	0	Human	Binding	pKi	=	7.0	7.0	-1	5	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	57326325	77182	None	0	Human	Binding	pKi	=	7.0	7.0	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL2042554	77182	None	0	Human	Binding	pKi	=	7.0	7.0	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL2078987	77182	None	0	Human	Binding	pKi	=	7.0	7.0	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	145960592	161359	None	0	Human	Binding	pKi	=	7.0	7.0	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4126071	161359	None	0	Human	Binding	pKi	=	7.0	7.0	-2	5	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	17621	60595	None	1	Rat	Binding	pKi	=	6.0	6.0	-2	2	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	375	6	1	3	2.8	CCN(CC)CC#CCN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
	CHEMBL176012	60595	None	1	Rat	Binding	pKi	=	6.0	6.0	-2	2	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	375	6	1	3	2.8	CCN(CC)CC#CCN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
	3072504	5810	None	7	Mouse	Binding	pKi	=	5.0	5.0	-	1	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL107892	5810	None	7	Mouse	Binding	pKi	=	5.0	5.0	-	1	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	71718668	86797	None	0	Rat	Binding	pKi	=	4.0	4.0	-1	2	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2321893	86797	None	0	Rat	Binding	pKi	=	4.0	4.0	-1	2	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	300	2508	None	15	Human	Binding	pKi	=	6.0	6.0	1	6	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
	4141	2508	None	15	Human	Binding	pKi	=	6.0	6.0	1	6	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
	CHEMBL92387	2508	None	15	Human	Binding	pKi	=	6.0	6.0	1	6	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
	2904292	183578	None	13	Human	Binding	pKi	=	4.0	4.0	-	1	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4800495	183578	None	13	Human	Binding	pKi	=	4.0	4.0	-	1	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	46227459	14133	None	0	Human	Binding	pKi	=	4.0	4.0	-1	2	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL1198076	14133	None	0	Human	Binding	pKi	=	4.0	4.0	-1	2	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL594802	14133	None	0	Human	Binding	pKi	=	4.0	4.0	-1	2	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	16125681	84766	None	0	Human	Binding	pKi	=	6.0	6.0	-141	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	481	5	1	2	5.6	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	CHEMBL223079	84766	None	0	Human	Binding	pKi	=	6.0	6.0	-141	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	481	5	1	2	5.6	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	10243426	121914	None	0	Human	Binding	pKi	=	7.0	7.0	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2csc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL359027	121914	None	0	Human	Binding	pKi	=	7.0	7.0	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2csc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
	16125374	84730	None	0	Human	Binding	pKi	=	7.0	7.0	-36	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	423	5	1	4	4.7	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL222860	84730	None	0	Human	Binding	pKi	=	7.0	7.0	-36	2	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	423	5	1	4	4.7	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	15050948	102815	None	0	Rat	Binding	pKi	=	6.0	6.0	1	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	513	7	3	7	1.8	NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	CHEMBL305403	102815	None	0	Rat	Binding	pKi	=	6.0	6.0	1	4	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	513	7	3	7	1.8	NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	10451634	204448	None	0	Human	Binding	pKi	=	7.0	7.0	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	367	10	0	4	4.1	CCN(CC)CCOCCOC(=O)C1(c2ccc(Cl)cc2)CCCC1	10.1021/jm00041a006
	CHEMBL72219	204448	None	0	Human	Binding	pKi	=	7.0	7.0	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	367	10	0	4	4.1	CCN(CC)CCOCCOC(=O)C1(c2ccc(Cl)cc2)CCCC1	10.1021/jm00041a006
	11808946	120634	None	0	Human	Binding	pKi	=	7.0	7.0	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL354678	120634	None	0	Human	Binding	pKi	=	7.0	7.0	2	5	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	47358375	180760	None	1	Human	Binding	pKi	=	7.0	7.0	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756164	180760	None	1	Human	Binding	pKi	=	7.0	7.0	2	4	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	87934	98079	None	24	Rat	Binding	pKi	=	6.0	6.0	-2	2	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	CHEMBL273308	98079	None	24	Rat	Binding	pKi	=	6.0	6.0	-2	2	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	CHEMBL542883	98079	None	24	Rat	Binding	pKi	=	6.0	6.0	-2	2	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	21862266	142011	None	0	Human	Binding	pKi	=	5.0	5.0	-3	2	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	183	0	0	3	0.8	C[C@H]1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	CHEMBL38756	142011	None	0	Human	Binding	pKi	=	5.0	5.0	-3	2	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	183	0	0	3	0.8	C[C@H]1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	10468535	98127	None	1	Human	Binding	pKi	=	7.0	7.0	-1	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	273	0	0	1	4.2	c1ccc2c(c1)C(=C1CN3CCC1CC3)c1ccccc1-2	10.1016/S0960-894X(01)80824-6
	CHEMBL273586	98127	None	1	Human	Binding	pKi	=	7.0	7.0	-1	3	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	273	0	0	1	4.2	c1ccc2c(c1)C(=C1CN3CCC1CC3)c1ccccc1-2	10.1016/S0960-894X(01)80824-6
	14964513	11417	None	0	Rat	Binding	pKi	=	6.0	6.0	-	1	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL1180268	11417	None	0	Rat	Binding	pKi	=	6.0	6.0	-	1	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL119508	11417	None	0	Rat	Binding	pKi	=	6.0	6.0	-	1	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	289	242	None	12	Human	Binding	pKi	=	6.0	6.0	-89	14	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
	9948320	242	None	12	Human	Binding	pKi	=	6.0	6.0	-89	14	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
	CHEMBL1242950	242	None	12	Human	Binding	pKi	=	6.0	6.0	-89	14	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
	137628799	160991	None	0	Human	Binding	pKi	=	6.0	6.0	7	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4064668	160991	None	0	Human	Binding	pKi	=	6.0	6.0	7	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116150	160991	None	0	Human	Binding	pKi	=	6.0	6.0	7	3	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	2166	3121	None	49	Rat	Binding	pKi	=	5.0	5.0	-4	8	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
	305	3121	None	49	Rat	Binding	pKi	=	5.0	5.0	-4	8	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
	5910	3121	None	49	Rat	Binding	pKi	=	5.0	5.0	-4	8	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
	CHEMBL550	3121	None	49	Rat	Binding	pKi	=	5.0	5.0	-4	8	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
	DB01085	3121	None	49	Rat	Binding	pKi	=	5.0	5.0	-4	8	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
	71716836	86952	None	0	Rat	Binding	pKi	=	5.0	5.0	-11	3	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323442	86952	None	0	Rat	Binding	pKi	=	5.0	5.0	-11	3	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	68617	205525	None	62	Human	Binding	pKi	=	6.0	6.0	-32	26	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL1709	205525	None	62	Human	Binding	pKi	=	6.0	6.0	-32	26	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL809	205525	None	62	Human	Binding	pKi	=	6.0	6.0	-32	26	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	462571	118793	None	1	Human	Binding	pKi	=	6.0	6.0	-97	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	517	4	0	5	5.2	Cc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
	CHEMBL342137	118793	None	1	Human	Binding	pKi	=	6.0	6.0	-97	2	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	517	4	0	5	5.2	Cc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
	10466231	36073	None	0	Human	Binding	pKi	=	7	7.0	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2coc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL144385	36073	None	0	Human	Binding	pKi	=	7	7.0	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2coc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
	10421689	35789	None	0	Human	Binding	pKi	=	6	6.0	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	239	1	0	1	1.8	C1=C(c2ccc[se]2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL144123	35789	None	0	Human	Binding	pKi	=	6	6.0	-2	2	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	239	1	0	1	1.8	C1=C(c2ccc[se]2)C2CCN1CC2	10.1021/jm00003a011
	1935	3732	None	97	Rat	Binding	pIC50	=	8.3	8.3	-	6	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	2551	3732	None	97	Rat	Binding	pIC50	=	8.3	8.3	-	6	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	6687	3732	None	97	Rat	Binding	pIC50	=	8.3	8.3	-	6	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	CHEMBL95	3732	None	97	Rat	Binding	pIC50	=	8.3	8.3	-	6	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	DB00382	3732	None	97	Rat	Binding	pIC50	=	8.3	8.3	-	6	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	154059	3635	None	51	Human	Binding	pIC50	=	8.2	8.2	-12	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	2457	3635	None	51	Human	Binding	pIC50	=	8.2	8.2	-12	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	7483	3635	None	51	Human	Binding	pIC50	=	8.2	8.2	-12	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	CHEMBL1734	3635	None	51	Human	Binding	pIC50	=	8.2	8.2	-12	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	DB01591	3635	None	51	Human	Binding	pIC50	=	8.2	8.2	-12	8	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	306	3454	None	21	Human	Binding	pIC50	=	8.2	8.2	-8	5	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
	3536	3454	None	21	Human	Binding	pIC50	=	8.2	8.2	-8	5	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
	53930639	3454	None	21	Human	Binding	pIC50	=	8.2	8.2	-8	5	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
	9577995	3454	None	21	Human	Binding	pIC50	=	8.2	8.2	-8	5	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
	CHEMBL134641	3454	None	21	Human	Binding	pIC50	=	8.2	8.2	-8	5	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
	2745	3859	None	42	Human	Binding	pIC50	=	8.1	8.1	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	5572	3859	None	42	Human	Binding	pIC50	=	8.1	8.1	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	66007	3859	None	42	Human	Binding	pIC50	=	8.1	8.1	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	7315	3859	None	42	Human	Binding	pIC50	=	8.1	8.1	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	CHEMBL1490	3859	None	42	Human	Binding	pIC50	=	8.1	8.1	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	DB00376	3859	None	42	Human	Binding	pIC50	=	8.1	8.1	-46	9	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	3652	4095	None	79	Rat	Binding	pIC50	=	8.1	8.1	-	18	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4095	None	79	Rat	Binding	pIC50	=	8.1	8.1	-	18	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4095	None	79	Rat	Binding	pIC50	=	8.1	8.1	-	18	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4095	None	79	Rat	Binding	pIC50	=	8.1	8.1	-	18	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4095	None	79	Rat	Binding	pIC50	=	8.1	8.1	-	18	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	2824	3991	None	0	Human	Binding	pKd	=	8.4	8.4	-2	4	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
	345	3991	None	0	Human	Binding	pKd	=	8.4	8.4	-2	4	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
	71203	3991	None	0	Human	Binding	pKd	=	8.4	8.4	-2	4	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
	CHEMBL1892145	3991	None	0	Human	Binding	pKd	=	8.4	8.4	-2	4	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
	DB13793	3991	None	0	Human	Binding	pKd	=	8.4	8.4	-2	4	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
	92112	21703	None	18	Human	Binding	pKd	=	8.4	8.4	1	4	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@@]12CCCN3CCc4c(n(c5ccccc45)C(=O)C1)[C@H]32	None
	CHEMBL1318553	21703	None	18	Human	Binding	pKd	=	8.4	8.4	1	4	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@@]12CCCN3CCc4c(n(c5ccccc45)C(=O)C1)[C@H]32	None
	2360	3691	None	43	Human	Binding	pKd	=	8.3	8.3	1	5	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	2484	3691	None	43	Human	Binding	pKd	=	8.3	8.3	1	5	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	347	3691	None	43	Human	Binding	pKd	=	8.3	8.3	1	5	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	441071	3691	None	43	Human	Binding	pKd	=	8.3	8.3	1	5	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	CHEMBL227934	3691	None	43	Human	Binding	pKd	=	8.3	8.3	1	5	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	DB15954	3691	None	43	Human	Binding	pKd	=	8.3	8.3	1	5	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	15376	3992	None	0	Human	Binding	pKd	=	8.3	8.3	-1	4	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
	349	3992	None	0	Human	Binding	pKd	=	8.3	8.3	-1	4	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
	3643	3992	None	0	Human	Binding	pKd	=	8.3	8.3	-1	4	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
	CHEMBL1165342	3992	None	0	Human	Binding	pKd	=	8.3	8.3	-1	4	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
	DB13374	3992	None	0	Human	Binding	pKd	=	8.3	8.3	-1	4	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
	21158560	112791	None	7	Human	Binding	pKd	=	8.2	8.2	-1	4	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	CHEMBL3305985	112791	None	7	Human	Binding	pKd	=	8.2	8.2	-1	4	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	2381	662	None	48	Human	Binding	pKd	=	8.1	8.1	-15	9	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	374	662	None	48	Human	Binding	pKd	=	8.1	8.1	-15	9	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	7128	662	None	48	Human	Binding	pKd	=	8.1	8.1	-15	9	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	CHEMBL1101	662	None	48	Human	Binding	pKd	=	8.1	8.1	-15	9	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	DB00810	662	None	48	Human	Binding	pKd	=	8.1	8.1	-15	9	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	11968014	12756	None	5	Rat	Binding	pKd	=	8.1	8.1	-3	9	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	119680147	12756	None	5	Rat	Binding	pKd	=	8.1	8.1	-3	9	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	CHEMBL1187846	12756	None	5	Rat	Binding	pKd	=	8.1	8.1	-3	9	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	DB00747	12756	None	5	Rat	Binding	pKd	=	8.1	8.1	-3	9	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	656598	12730	None	6	Rat	Binding	pKd	=	8.1	8.1	-2	4	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL1187724	12730	None	6	Rat	Binding	pKd	=	8.1	8.1	-2	4	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL516476	12730	None	6	Rat	Binding	pKd	=	8.1	8.1	-2	4	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	367	3822	None	12	Human	Binding	pKd	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	5487427	3822	None	12	Human	Binding	pKd	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	8592	3822	None	12	Human	Binding	pKd	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	CHEMBL1900528	3822	None	12	Human	Binding	pKd	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	CHEMBL3305968	3822	None	12	Human	Binding	pKd	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	CHEMBL4650755	3822	None	12	Human	Binding	pKd	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	DB01409	3822	None	12	Human	Binding	pKd	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	23056	112	None	29	Human	Binding	pKd	=	10.4	10.4	-1	8	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
	23056	112	None	29	Human	Binding	pKd	=	10.4	10.4	-1	8	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
	318	112	None	29	Human	Binding	pKd	=	10.4	10.4	-1	8	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
	318	112	None	29	Human	Binding	pKd	=	10.4	10.4	-1	8	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
	3260	112	None	29	Human	Binding	pKd	=	10.4	10.4	-1	8	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
	3260	112	None	29	Human	Binding	pKd	=	10.4	10.4	-1	8	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
	CHEMBL12980	112	None	29	Human	Binding	pKd	=	10.4	10.4	-1	8	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
	CHEMBL12980	112	None	29	Human	Binding	pKd	=	10.4	10.4	-1	8	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
	11536903	2395	None	68	Human	Binding	pKd	=	4.4	4.4	-6	2	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
	3262	2395	None	68	Human	Binding	pKd	=	4.4	4.4	-6	2	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
	CHEMBL3770346	2395	None	68	Human	Binding	pKd	=	4.4	4.4	-6	2	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
	57664406	2396	None	50	Human	Binding	pKd	=	5.6	5.6	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
	57664406	2396	None	50	Human	Binding	pKd	=	5.6	5.6	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
	6938	2396	None	50	Human	Binding	pKd	=	5.6	5.6	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
	6938	2396	None	50	Human	Binding	pKd	=	5.6	5.6	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
	CHEMBL4089376	2396	None	50	Human	Binding	pKd	=	5.6	5.6	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
	CHEMBL4089376	2396	None	50	Human	Binding	pKd	=	5.6	5.6	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
	1273	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	1273	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	3450	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	3450	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	356	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	356	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	6172	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	6172	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	67425	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	67425	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	CHEMBL360055	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	CHEMBL360055	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	DB00483	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	DB00483	1752	None	16	Human	Binding	pKd	=	6.1	6.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	341	340	None	0	Human	Binding	pKd	=	6.5	6.5	5	4	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	12815174
	341	340	None	0	Human	Binding	pKd	=	6.5	6.5	5	4	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	17591774
	341	340	None	0	Human	Binding	pKd	=	6.5	6.5	5	4	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	9224827
	5311001	340	None	0	Human	Binding	pKd	=	6.5	6.5	5	4	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	12815174
	5311001	340	None	0	Human	Binding	pKd	=	6.5	6.5	5	4	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	17591774
	5311001	340	None	0	Human	Binding	pKd	=	6.5	6.5	5	4	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	9224827
	167962	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	167962	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
	362	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	362	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
	CHEMBL31599	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	CHEMBL31599	4067	None	4	Human	Binding	pKd	=	6.8	6.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
	168057	1211	None	11	Human	Binding	pKd	=	7.1	7.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
	168057	1211	None	11	Human	Binding	pKd	=	7.1	7.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
	7634	1211	None	11	Human	Binding	pKd	=	7.1	7.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
	7634	1211	None	11	Human	Binding	pKd	=	7.1	7.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
	CHEMBL28407	1211	None	11	Human	Binding	pKd	=	7.1	7.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
	CHEMBL28407	1211	None	11	Human	Binding	pKd	=	7.1	7.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
	2381	662	None	48	Human	Binding	pKd	=	8.2	8.2	-15	9	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
	374	662	None	48	Human	Binding	pKd	=	8.2	8.2	-15	9	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
	7128	662	None	48	Human	Binding	pKd	=	8.2	8.2	-15	9	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
	CHEMBL1101	662	None	48	Human	Binding	pKd	=	8.2	8.2	-15	9	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
	DB00810	662	None	48	Human	Binding	pKd	=	8.2	8.2	-15	9	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
	10350027	1427	None	0	Human	Binding	pKd	=	8.5	8.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	364	1427	None	0	Human	Binding	pKd	=	8.5	8.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	365	1427	None	0	Human	Binding	pKd	=	8.5	8.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	303	2976	None	17	Human	Binding	pKd	=	8.7	8.7	-1	6	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
	4629	2976	None	17	Human	Binding	pKd	=	8.7	8.7	-1	6	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
	8595	2976	None	17	Human	Binding	pKd	=	8.7	8.7	-1	6	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
	CHEMBL44674	2976	None	17	Human	Binding	pKd	=	8.7	8.7	-1	6	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
	187	255	None	39	Human	Binding	pKd	=	8.8	8.8	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	294	255	None	39	Human	Binding	pKd	=	8.8	8.8	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	65	255	None	39	Human	Binding	pKd	=	8.8	8.8	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	8593	255	None	39	Human	Binding	pKd	=	8.8	8.8	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	CHEMBL667	255	None	39	Human	Binding	pKd	=	8.8	8.8	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	DB03128	255	None	39	Human	Binding	pKd	=	8.8	8.8	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	119357	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
	119357	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
	119357	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
	3264	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
	3264	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
	3264	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
	368	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
	368	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
	368	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
	CHEMBL279453	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
	CHEMBL279453	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
	CHEMBL279453	304	None	49	Human	Binding	pKd	=	9	9.0	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
	23724781	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	23724781	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	23724781	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	23724781	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	23724781	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	23724781	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	23724781	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	316	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	316	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	316	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	316	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	316	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	316	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	316	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	317	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	317	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	317	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	317	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	317	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	317	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	317	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	71183	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	71183	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	71183	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	71183	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	71183	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	71183	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	71183	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	CHEMBL1354199	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	CHEMBL1354199	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	CHEMBL1354199	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	CHEMBL1354199	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	CHEMBL1354199	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	CHEMBL1354199	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	CHEMBL1354199	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	CHEMBL3140030	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	CHEMBL3140030	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	CHEMBL3140030	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	CHEMBL3140030	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	CHEMBL3140030	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	CHEMBL3140030	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	CHEMBL3140030	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	CHEMBL376897	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	CHEMBL376897	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	CHEMBL376897	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	CHEMBL376897	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	CHEMBL376897	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	CHEMBL376897	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	CHEMBL376897	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	DB00462	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	DB00462	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	DB00462	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	DB00462	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	DB00462	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	DB00462	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	DB00462	2833	None	19	Human	Binding	pKd	=	9.6	9.6	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	21123938	732	None	0	Human	Binding	pKd	None	3.5	3.5	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	410	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-]	9495826
	343	732	None	0	Human	Binding	pKd	None	3.5	3.5	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	410	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-]	9495826
	348	3801	None	0	Human	Binding	pKd	None	3.9	3.9	-3	4	UnclassifiedUnclassified	Guide to Pharmacology	262	2	1	6	1.9	OCCc1sc2=Nc3c(Cn2c1C)cnc(n3)C	14722259
	66706	3801	None	0	Human	Binding	pKd	None	3.9	3.9	-3	4	UnclassifiedUnclassified	Guide to Pharmacology	262	2	1	6	1.9	OCCc1sc2=Nc3c(Cn2c1C)cnc(n3)C	14722259
	2824	3991	None	0	Human	Binding	pKd	None	4.2	4.2	-2	4	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
	345	3991	None	0	Human	Binding	pKd	None	4.2	4.2	-2	4	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
	71203	3991	None	0	Human	Binding	pKd	None	4.2	4.2	-2	4	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
	CHEMBL1892145	3991	None	0	Human	Binding	pKd	None	4.2	4.2	-2	4	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
	DB13793	3991	None	0	Human	Binding	pKd	None	4.2	4.2	-2	4	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
	342	731	None	55	Human	Binding	pKd	None	4.3	4.3	-9	5	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	442021	731	None	55	Human	Binding	pKd	None	4.3	4.3	-9	5	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	CHEMBL501756	731	None	55	Human	Binding	pKd	None	4.3	4.3	-9	5	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	342	731	None	55	Human	Binding	pKd	None	4.5	4.5	-9	5	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
	342	731	None	55	Human	Binding	pKd	None	4.5	4.5	-9	5	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	442021	731	None	55	Human	Binding	pKd	None	4.5	4.5	-9	5	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
	442021	731	None	55	Human	Binding	pKd	None	4.5	4.5	-9	5	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	CHEMBL501756	731	None	55	Human	Binding	pKd	None	4.5	4.5	-9	5	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
	CHEMBL501756	731	None	55	Human	Binding	pKd	None	4.5	4.5	-9	5	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	344	2747	None	0	Human	Binding	pKd	None	4.6	4.6	1	5	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
	44358908	2747	None	0	Human	Binding	pKd	None	4.6	4.6	1	5	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
	CHEMBL139677	2747	None	0	Human	Binding	pKd	None	4.6	4.6	1	5	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
	332	2032	None	0	Human	Binding	pKd	None	4.8	4.8	1	5	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
	44358893	2032	None	0	Human	Binding	pKd	None	4.8	4.8	1	5	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
	CHEMBL343796	2032	None	0	Human	Binding	pKd	None	4.8	4.8	1	5	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
	2360	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	2360	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	2360	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	2484	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	2484	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	2484	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	347	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	347	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	347	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	441071	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	441071	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	441071	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	CHEMBL227934	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	CHEMBL227934	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	CHEMBL227934	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	DB15954	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	DB15954	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	DB15954	3691	None	43	Human	Binding	pKd	None	5.0	5.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	335	1834	None	0	Human	Binding	pKd	None	5	5.0	-6	4	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
	3500	1834	None	0	Human	Binding	pKd	None	5	5.0	-6	4	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
	CHEMBL157822	1834	None	0	Human	Binding	pKd	None	5	5.0	-6	4	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
	346	3687	None	0	Human	Binding	pKd	None	5.1	5.1	-6	3	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
	44259	3687	None	0	Human	Binding	pKd	None	5.1	5.1	-6	3	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
	CHEMBL388978	3687	None	0	Human	Binding	pKd	None	5.1	5.1	-6	3	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
	DB02010	3687	None	0	Human	Binding	pKd	None	5.1	5.1	-6	3	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
	15376	3992	None	0	Human	Binding	pKd	None	5.1	5.1	-1	4	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
	349	3992	None	0	Human	Binding	pKd	None	5.1	5.1	-1	4	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
	3643	3992	None	0	Human	Binding	pKd	None	5.1	5.1	-1	4	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
	CHEMBL1165342	3992	None	0	Human	Binding	pKd	None	5.1	5.1	-1	4	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
	DB13374	3992	None	0	Human	Binding	pKd	None	5.1	5.1	-1	4	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
	15118529	4081	None	0	Human	Binding	pKd	None	5.3	5.3	-3	4	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
	340	4081	None	0	Human	Binding	pKd	None	5.3	5.3	-3	4	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
	CHEMBL1256845	4081	None	0	Human	Binding	pKd	None	5.3	5.3	-3	4	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
	108152	2199	None	0	Human	Binding	pKd	None	5.7	5.7	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	495	2	0	7	4.7	COC(=O)[C@@]1(OC)C[C@H]2O[C@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CN(C1=O)C	10860942
	338	2199	None	0	Human	Binding	pKd	None	5.7	5.7	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	495	2	0	7	4.7	COC(=O)[C@@]1(OC)C[C@H]2O[C@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CN(C1=O)C	10860942
	339	4079	None	0	Human	Binding	pKd	None	5.9	5.9	-1	4	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
	9803245	4079	None	0	Human	Binding	pKd	None	5.9	5.9	-1	4	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
	CHEMBL2206331	4079	None	0	Human	Binding	pKd	None	5.9	5.9	-1	4	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
	2784	951	None	13	Rat	Binding	pKd	None	9.5	9.5	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	351	951	None	13	Rat	Binding	pKd	None	9.5	9.5	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	366	951	None	13	Rat	Binding	pKd	None	9.5	9.5	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	676	951	None	13	Rat	Binding	pKd	None	9.5	9.5	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	CHEMBL620	951	None	13	Rat	Binding	pKd	None	9.5	9.5	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	DB00771	951	None	13	Rat	Binding	pKd	None	9.5	9.5	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	23724781	2833	None	19	Rat	Binding	pKd	None	9.5	9.5	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	316	2833	None	19	Rat	Binding	pKd	None	9.5	9.5	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	317	2833	None	19	Rat	Binding	pKd	None	9.5	9.5	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	71183	2833	None	19	Rat	Binding	pKd	None	9.5	9.5	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	CHEMBL1354199	2833	None	19	Rat	Binding	pKd	None	9.5	9.5	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	CHEMBL3140030	2833	None	19	Rat	Binding	pKd	None	9.5	9.5	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	CHEMBL376897	2833	None	19	Rat	Binding	pKd	None	9.5	9.5	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	DB00462	2833	None	19	Rat	Binding	pKd	None	9.5	9.5	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	2784	951	None	13	Human	Binding	pKd	None	9.6	9.6	1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	351	951	None	13	Human	Binding	pKd	None	9.6	9.6	1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	366	951	None	13	Human	Binding	pKd	None	9.6	9.6	1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	676	951	None	13	Human	Binding	pKd	None	9.6	9.6	1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	CHEMBL620	951	None	13	Human	Binding	pKd	None	9.6	9.6	1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	DB00771	951	None	13	Human	Binding	pKd	None	9.6	9.6	1	3	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	23056	112	3H-QNB	29	Human	Binding	pKi	=	10.5	10.5	-1	8	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	318	112	3H-QNB	29	Human	Binding	pKi	=	10.5	10.5	-1	8	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	3260	112	3H-QNB	29	Human	Binding	pKi	=	10.5	10.5	-1	8	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	CHEMBL12980	112	3H-QNB	29	Human	Binding	pKi	=	10.5	10.5	-1	8	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	23056	112	3H-QNB	29	Human	Binding	pKi	=	10.6	10.6	-1	8	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	318	112	3H-QNB	29	Human	Binding	pKi	=	10.6	10.6	-1	8	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	3260	112	3H-QNB	29	Human	Binding	pKi	=	10.6	10.6	-1	8	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	CHEMBL12980	112	3H-QNB	29	Human	Binding	pKi	=	10.6	10.6	-1	8	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	44431393	88022	UNDEFINED	0	Human	Binding	pKi	=	9.9	9.9	1	3	NoneNone	PDSP KiDatabase	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	None
	CHEMBL234440	88022	UNDEFINED	0	Human	Binding	pKi	=	9.9	9.9	1	3	NoneNone	PDSP KiDatabase	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	None
	1427	2011	3H-MQNB(-)	54	Human	Binding	pKi	=	9.9	9.9	1	27	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2011	3H-MQNB(-)	54	Human	Binding	pKi	=	9.9	9.9	1	27	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2011	3H-MQNB(-)	54	Human	Binding	pKi	=	9.9	9.9	1	27	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2011	3H-MQNB(-)	54	Human	Binding	pKi	=	9.9	9.9	1	27	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2011	3H-MQNB(-)	54	Human	Binding	pKi	=	9.9	9.9	1	27	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	132947	3862	3H-NMS	9	Human	Binding	pKi	=	9.6	9.6	1	9	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
	361	3862	3H-NMS	9	Human	Binding	pKi	=	9.6	9.6	1	9	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
	CHEMBL265256	3862	3H-NMS	9	Human	Binding	pKi	=	9.6	9.6	1	9	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
	325	2060	3H-NMS	0	Rat	Binding	pKi	=	9.4	9.4	-1	9	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	3746	2060	3H-NMS	0	Rat	Binding	pKi	=	9.4	9.4	-1	9	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	657308	2060	3H-NMS	0	Rat	Binding	pKi	=	9.4	9.4	-1	9	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	CHEMBL1615433	2060	3H-NMS	0	Rat	Binding	pKi	=	9.4	9.4	-1	9	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	DB00332	2060	3H-NMS	0	Rat	Binding	pKi	=	9.4	9.4	-1	9	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	187	255	3H-NMS	39	Human	Binding	pKi	=	9.4	9.4	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	3H-NMS	39	Human	Binding	pKi	=	9.4	9.4	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	3H-NMS	39	Human	Binding	pKi	=	9.4	9.4	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	3H-NMS	39	Human	Binding	pKi	=	9.4	9.4	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	3H-NMS	39	Human	Binding	pKi	=	9.4	9.4	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	3H-NMS	39	Human	Binding	pKi	=	9.4	9.4	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	131632304	216035	3H-QNB	0	Human	Binding	pKi	=	9.4	9.4	-6	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	5184	216035	3H-QNB	0	Human	Binding	pKi	=	9.4	9.4	-6	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	CHEMBL13030	216035	3H-QNB	0	Human	Binding	pKi	=	9.4	9.4	-6	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	DB00747	216035	3H-QNB	0	Human	Binding	pKi	=	9.4	9.4	-6	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	12057539	208039	3H-MQNB(-)	42	Human	Binding	pKi	=	9.2	9.2	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-MQNB(-)	42	Human	Binding	pKi	=	9.2	9.2	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-MQNB(-)	42	Human	Binding	pKi	=	9.2	9.2	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	44431384	148858	UNDEFINED	0	Human	Binding	pKi	=	9.2	9.2	2	3	NoneNone	PDSP KiDatabase	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	None
	CHEMBL394137	148858	UNDEFINED	0	Human	Binding	pKi	=	9.2	9.2	2	3	NoneNone	PDSP KiDatabase	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	None
	12057539	208039	3H-PIRENZEPINE	42	Rat	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-PIRENZEPINE	42	Rat	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-PIRENZEPINE	42	Rat	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208039	3H-MQNB(-)	42	Rat	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-MQNB(-)	42	Rat	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-MQNB(-)	42	Rat	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208039	3H-NMS	42	Human	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208039	3H-NMSP	42	Human	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208039	3H-QNB	42	Human	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-NMS	42	Human	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-NMSP	42	Human	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-QNB	42	Human	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-NMS	42	Human	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-NMSP	42	Human	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-QNB	42	Human	Binding	pKi	=	9.1	9.1	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208039	3H-NMS	42	Rat	Binding	pKi	=	9.0	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-NMS	42	Rat	Binding	pKi	=	9.0	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-NMS	42	Rat	Binding	pKi	=	9.0	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208039	3H-MQNB(-)	42	Rat	Binding	pKi	=	9	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-MQNB(-)	42	Rat	Binding	pKi	=	9	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-MQNB(-)	42	Rat	Binding	pKi	=	9	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208039	3H-Arachidonic Acid	42	Human	Binding	pKi	=	9	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208039	3H-NMS	42	Human	Binding	pKi	=	9	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-Arachidonic Acid	42	Human	Binding	pKi	=	9	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-NMS	42	Human	Binding	pKi	=	9	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-Arachidonic Acid	42	Human	Binding	pKi	=	9	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-NMS	42	Human	Binding	pKi	=	9	9.0	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	24835791	216102	3H-MQNB(-)	0	Human	Binding	pKi	=	8.9	8.9	1	2	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	5831	215961	3H-QNB	0	Human	Binding	pKi	=	8.9	8.9	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	3H-QNB	0	Human	Binding	pKi	=	8.9	8.9	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	3H-QNB	0	Human	Binding	pKi	=	8.9	8.9	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	42470	216181	3H-NMS	0	Rat	Binding	pKi	=	8.9	8.9	-3	6	NoneNone	PDSP KiDatabase	345	10	0	3	4.9	CCN(CCCC(=O)C1CCCCC1)C(C)CC2=CC=C(C=C2)OC	None
	3246155	215960	3H-QNB	0	Human	Binding	pKi	=	8.9	8.9	-6	17	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
	131632304	216035	3H-NMS	0	Rat	Binding	pKi	=	8.9	8.9	-10	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	5184	216035	3H-NMS	0	Rat	Binding	pKi	=	8.9	8.9	-10	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	CHEMBL13030	216035	3H-NMS	0	Rat	Binding	pKi	=	8.9	8.9	-10	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	DB00747	216035	3H-NMS	0	Rat	Binding	pKi	=	8.9	8.9	-10	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	325	2060	3H-NMS	0	Human	Binding	pKi	=	8.8	8.8	-3	9	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	3746	2060	3H-NMS	0	Human	Binding	pKi	=	8.8	8.8	-3	9	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	657308	2060	3H-NMS	0	Human	Binding	pKi	=	8.8	8.8	-3	9	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	CHEMBL1615433	2060	3H-NMS	0	Human	Binding	pKi	=	8.8	8.8	-3	9	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	DB00332	2060	3H-NMS	0	Human	Binding	pKi	=	8.8	8.8	-3	9	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	12057539	208039	3H-NMS	42	Human	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208039	3H-QNB	42	Human	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208039	3H-MQNB(-)	42	Rat	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-NMS	42	Human	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-QNB	42	Human	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-MQNB(-)	42	Rat	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-NMS	42	Human	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-QNB	42	Human	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-MQNB(-)	42	Rat	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	24835791	216102	3H-MQNB(-)	0	Rat	Binding	pKi	=	8.8	8.8	-1	2	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	12057539	208039	3H-QNB	42	Rat	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	3H-QNB	42	Rat	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	3H-QNB	42	Rat	Binding	pKi	=	8.8	8.8	-2	21	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	16721019	87984	UNDEFINED	0	Human	Binding	pKi	=	8.7	8.7	1	3	NoneNone	PDSP KiDatabase	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	None
	CHEMBL234258	87984	UNDEFINED	0	Human	Binding	pKi	=	8.7	8.7	1	3	NoneNone	PDSP KiDatabase	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	None
	44431389	146149	UNDEFINED	0	Human	Binding	pKi	=	8.7	8.7	1	3	NoneNone	PDSP KiDatabase	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	None
	CHEMBL391977	146149	UNDEFINED	0	Human	Binding	pKi	=	8.7	8.7	1	3	NoneNone	PDSP KiDatabase	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	None
	1734	116	3H-PIRENZEPINE	10	Rat	Binding	pKi	=	8	8.0	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	3H-PIRENZEPINE	10	Rat	Binding	pKi	=	8	8.0	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	3H-PIRENZEPINE	10	Rat	Binding	pKi	=	8	8.0	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	135398737	957	3H-NMS	93	Rat	Binding	pKi	=	8	8.0	-6	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	957	3H-QNB	93	Rat	Binding	pKi	=	8	8.0	-6	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	957	3H-NMS	93	Rat	Binding	pKi	=	8	8.0	-6	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	957	3H-QNB	93	Rat	Binding	pKi	=	8	8.0	-6	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	957	3H-NMS	93	Rat	Binding	pKi	=	8	8.0	-6	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	957	3H-QNB	93	Rat	Binding	pKi	=	8	8.0	-6	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	957	3H-NMS	93	Rat	Binding	pKi	=	8	8.0	-6	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	957	3H-QNB	93	Rat	Binding	pKi	=	8	8.0	-6	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	957	3H-NMS	93	Rat	Binding	pKi	=	8	8.0	-6	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	957	3H-QNB	93	Rat	Binding	pKi	=	8	8.0	-6	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	154825138	216036	3H-4-DAMP	0	Human	Binding	pKi	=	8	8.0	-1	12	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	154825138	216036	3H-NMS	0	Human	Binding	pKi	=	8	8.0	-1	12	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	11434515	261	None	6	Human	Binding	pKi	=	8	8.0	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	11519741	261	None	6	Human	Binding	pKi	=	8	8.0	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	4484	261	None	6	Human	Binding	pKi	=	8	8.0	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	7449	261	None	6	Human	Binding	pKi	=	8	8.0	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	CHEMBL1194325	261	None	6	Human	Binding	pKi	=	8	8.0	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	DB08897	261	None	6	Human	Binding	pKi	=	8	8.0	-6	5	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	154825138	216036	3H-MQNB(-)	0	Rat	Binding	pKi	=	8.0	8.0	-1	12	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	2381	662	3H-NMS	48	Rat	Binding	pKi	=	8.0	8.0	-19	9	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	374	662	3H-NMS	48	Rat	Binding	pKi	=	8.0	8.0	-19	9	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	7128	662	3H-NMS	48	Rat	Binding	pKi	=	8.0	8.0	-19	9	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	CHEMBL1101	662	3H-NMS	48	Rat	Binding	pKi	=	8.0	8.0	-19	9	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	DB00810	662	3H-NMS	48	Rat	Binding	pKi	=	8.0	8.0	-19	9	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	71202	216370	3H-NMS	0	Rat	Binding	pKi	=	8.0	8.0	-3	5	NoneNone	PDSP KiDatabase	340	3	0	3	4.9	CC1(C2=CC=CC=C2N(C3=CC=CC=C31)C(=O)SCCN(C)C)C	None
	202	1507	UNDEFINED	77	Human	Binding	pKi	=	6	6.0	-9	33	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	60835	1507	UNDEFINED	77	Human	Binding	pKi	=	6	6.0	-9	33	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	972	1507	UNDEFINED	77	Human	Binding	pKi	=	6	6.0	-9	33	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	CHEMBL1175	1507	UNDEFINED	77	Human	Binding	pKi	=	6	6.0	-9	33	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	DB00476	1507	UNDEFINED	77	Human	Binding	pKi	=	6	6.0	-9	33	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	5656	203064	UNDEFINED	87	Human	Binding	pKi	=	6	6.0	-25	43	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	CHEMBL637	203064	UNDEFINED	87	Human	Binding	pKi	=	6	6.0	-25	43	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	54841	203125	UNDEFINED	52	Human	Binding	pKi	=	6	6.0	-1	30	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
	CHEMBL641	203125	UNDEFINED	52	Human	Binding	pKi	=	6	6.0	-1	30	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
	11957621	216037	3H-NMS	0	Human	Binding	pKi	=	6	6.0	-12	10	NoneNone	PDSP KiDatabase	203	3	2	3	1.3	COC1=C(C=CC(=C1)CCN)O.Cl	None
	11957621	216037	3H-NMS	0	Rat	Binding	pKi	=	6	6.0	-12	10	NoneNone	PDSP KiDatabase	203	3	2	3	1.3	COC1=C(C=CC(=C1)CCN)O.Cl	None
	3075702	217330	3H-AF-DX384	0	Human	Binding	pKi	=	6	6.0	-2	37	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
	145	140	3H-QNB	49	Human	Binding	pKi	=	5	5.0	-1949	30	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	3H-QNB	49	Human	Binding	pKi	=	5	5.0	-1949	30	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	3H-QNB	49	Human	Binding	pKi	=	5	5.0	-1949	30	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	3H-QNB	49	Human	Binding	pKi	=	5	5.0	-1949	30	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	179	400	3H-QNB	115	Human	Binding	pKi	=	5	5.0	-4365	51	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	400	3H-QNB	115	Human	Binding	pKi	=	5	5.0	-4365	51	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	400	3H-QNB	115	Human	Binding	pKi	=	5	5.0	-4365	51	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	400	3H-QNB	115	Human	Binding	pKi	=	5	5.0	-4365	51	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	400	3H-QNB	115	Human	Binding	pKi	=	5	5.0	-4365	51	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	141	1426	3H-QNB	35	Human	Binding	pKi	=	5	5.0	-114	22	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	6089	1426	3H-QNB	35	Human	Binding	pKi	=	5	5.0	-114	22	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	CHEMBL12420	1426	3H-QNB	35	Human	Binding	pKi	=	5	5.0	-114	22	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	DB01488	1426	3H-QNB	35	Human	Binding	pKi	=	5	5.0	-114	22	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	119376	1839	3H-NMS	48	Rat	Binding	pKi	=	5	5.0	-54954	27	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	247	1839	3H-NMS	48	Rat	Binding	pKi	=	5	5.0	-54954	27	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	CHEMBL33884	1839	3H-NMS	48	Rat	Binding	pKi	=	5	5.0	-54954	27	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	1353	1909	3H-QNB	93	Human	Binding	pKi	=	5	5.0	-5011	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1909	3H-QNB	93	Human	Binding	pKi	=	5	5.0	-5011	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1909	3H-QNB	93	Human	Binding	pKi	=	5	5.0	-5011	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1909	3H-QNB	93	Human	Binding	pKi	=	5	5.0	-5011	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1909	3H-QNB	93	Human	Binding	pKi	=	5	5.0	-5011	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1588	2323	3H-QNB	27	Human	Binding	pKi	=	5	5.0	-28840	44	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2323	3H-QNB	27	Human	Binding	pKi	=	5	5.0	-28840	44	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2323	3H-QNB	27	Human	Binding	pKi	=	5	5.0	-28840	44	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2323	3H-QNB	27	Human	Binding	pKi	=	5	5.0	-28840	44	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2323	3H-QNB	27	Human	Binding	pKi	=	5	5.0	-28840	44	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	290	2471	3H-MQNB(-)	6	Rat	Binding	pKi	=	5	5.0	-12	7	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
	4022	2471	3H-MQNB(-)	6	Rat	Binding	pKi	=	5	5.0	-12	7	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
	5926	2471	3H-MQNB(-)	6	Rat	Binding	pKi	=	5	5.0	-12	7	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
	CHEMBL40554	2471	3H-MQNB(-)	6	Rat	Binding	pKi	=	5	5.0	-12	7	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
	CHEMBL74300	2471	3H-MQNB(-)	6	Rat	Binding	pKi	=	5	5.0	-12	7	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
	15897	2860	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-204	37	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2860	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-204	37	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2860	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-204	37	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	2166	3121	3H-MQNB(-)	49	Rat	Binding	pKi	=	5	5.0	-4	8	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	305	3121	3H-MQNB(-)	49	Rat	Binding	pKi	=	5	5.0	-4	8	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5910	3121	3H-MQNB(-)	49	Rat	Binding	pKi	=	5	5.0	-4	8	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	CHEMBL550	3121	3H-MQNB(-)	49	Rat	Binding	pKi	=	5	5.0	-4	8	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	DB01085	3121	3H-MQNB(-)	49	Rat	Binding	pKi	=	5	5.0	-4	8	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	2200	3129	3H-NMS	46	Human	Binding	pKi	=	5	5.0	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-NMS	46	Human	Binding	pKi	=	5	5.0	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-NMS	46	Human	Binding	pKi	=	5	5.0	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-NMS	46	Human	Binding	pKi	=	5	5.0	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-NMS	46	Human	Binding	pKi	=	5	5.0	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	119570	3157	3H-QNB	96	Human	Binding	pKi	=	5	5.0	-7585	40	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3157	3H-QNB	96	Human	Binding	pKi	=	5	5.0	-7585	40	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3157	3H-QNB	96	Human	Binding	pKi	=	5	5.0	-7585	40	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3157	3H-QNB	96	Human	Binding	pKi	=	5	5.0	-7585	40	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3157	3H-QNB	96	Human	Binding	pKi	=	5	5.0	-7585	40	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2389	3329	3H-QNB	118	Human	Binding	pKi	=	5	5.0	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3329	3H-QNB	118	Human	Binding	pKi	=	5	5.0	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3329	3H-QNB	118	Human	Binding	pKi	=	5	5.0	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3329	3H-QNB	118	Human	Binding	pKi	=	5	5.0	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3329	3H-QNB	118	Human	Binding	pKi	=	5	5.0	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	128563	3462	3H-QNB	33	Human	Binding	pKi	=	5	5.0	-2398	42	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	1666	3462	3H-QNB	33	Human	Binding	pKi	=	5	5.0	-2398	42	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	CHEMBL445332	3462	3H-QNB	33	Human	Binding	pKi	=	5	5.0	-2398	42	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	DB12327	3462	3H-QNB	33	Human	Binding	pKi	=	5	5.0	-2398	42	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	6917970	3689	3H-QNB	61	Human	Binding	pKi	=	5	5.0	-2290	34	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	8370	3689	3H-QNB	61	Human	Binding	pKi	=	5	5.0	-2290	34	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	CHEMBL487387	3689	3H-QNB	61	Human	Binding	pKi	=	5	5.0	-2290	34	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	1267	3802	3H-NMS	49	Rat	Binding	pKi	=	5	5.0	-4168	28	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
	3035905	3802	3H-NMS	49	Rat	Binding	pKi	=	5	5.0	-4168	28	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
	CHEMBL260374	3802	3H-NMS	49	Rat	Binding	pKi	=	5	5.0	-4168	28	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
	213	3851	3H-QNB	55	Human	Binding	pKi	=	5	5.0	-912	44	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3851	3H-QNB	55	Human	Binding	pKi	=	5	5.0	-912	44	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3851	3H-QNB	55	Human	Binding	pKi	=	5	5.0	-912	44	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3851	3H-QNB	55	Human	Binding	pKi	=	5	5.0	-912	44	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3851	3H-QNB	55	Human	Binding	pKi	=	5	5.0	-912	44	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	185	4004	3H-QNB	60	Human	Binding	pKi	=	5	5.0	-30902	38	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	5311271	4004	3H-QNB	60	Human	Binding	pKi	=	5	5.0	-30902	38	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	CHEMBL74355	4004	3H-QNB	60	Human	Binding	pKi	=	5	5.0	-30902	38	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	DB16351	4004	3H-QNB	60	Human	Binding	pKi	=	5	5.0	-30902	38	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	2865	4141	3H-QNB	73	Human	Binding	pKi	=	5	5.0	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4141	3H-QNB	73	Human	Binding	pKi	=	5	5.0	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4141	3H-QNB	73	Human	Binding	pKi	=	5	5.0	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4141	3H-QNB	73	Human	Binding	pKi	=	5	5.0	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4141	3H-QNB	73	Human	Binding	pKi	=	5	5.0	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	103	4151	3H-QNB	61	Human	Binding	pKi	=	5	5.0	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4151	3H-QNB	61	Human	Binding	pKi	=	5	5.0	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4151	3H-QNB	61	Human	Binding	pKi	=	5	5.0	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4151	3H-QNB	61	Human	Binding	pKi	=	5	5.0	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4151	3H-QNB	61	Human	Binding	pKi	=	5	5.0	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2662	11382	3H-QNB	131	Human	Binding	pKi	=	5	5.0	-41	31	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	CHEMBL118	11382	3H-QNB	131	Human	Binding	pKi	=	5	5.0	-41	31	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	5090	15559	3H-QNB	106	Human	Binding	pKi	=	5	5.0	-1348	31	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	CHEMBL122	15559	3H-QNB	106	Human	Binding	pKi	=	5	5.0	-1348	31	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	10297	27110	3H-QNB	30	Human	Binding	pKi	=	5	5.0	-38	44	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
	CHEMBL136560	27110	3H-QNB	30	Human	Binding	pKi	=	5	5.0	-38	44	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
	156391	46798	3H-QNB	99	Human	Binding	pKi	=	5	5.0	-1	30	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL1200806	46798	3H-QNB	99	Human	Binding	pKi	=	5	5.0	-1	30	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL154	46798	3H-QNB	99	Human	Binding	pKi	=	5	5.0	-1	30	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	115237	55583	3H-QNB	119	Human	Binding	pKi	=	5	5.0	-42657	55	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55583	3H-QNB	119	Human	Binding	pKi	=	5	5.0	-42657	55	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	DB01267	55583	3H-QNB	119	Human	Binding	pKi	=	5	5.0	-42657	55	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	10624	70298	3H-QNB	19	Human	Binding	pKi	=	5	5.0	-776	33	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	138543650	70298	3H-QNB	19	Human	Binding	pKi	=	5	5.0	-776	33	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	CHEMBL194378	70298	3H-QNB	19	Human	Binding	pKi	=	5	5.0	-776	33	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	DB11664	70298	3H-QNB	19	Human	Binding	pKi	=	5	5.0	-776	33	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	1979	77324	3H-cAMP	70	Rat	Binding	pKi	=	5	5.0	-14	4	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77324	3H-cAMP	70	Rat	Binding	pKi	=	5	5.0	-14	4	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	2244	94231	3H-QNB	100	Human	Binding	pKi	=	5	5.0	-1	28	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	CHEMBL25	94231	3H-QNB	100	Human	Binding	pKi	=	5	5.0	-1	28	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	3025067	99380	3H-NMS	64	Rat	Binding	pKi	=	5	5.0	-512	15	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
	65853	99380	3H-NMS	64	Rat	Binding	pKi	=	5	5.0	-512	15	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
	CHEMBL282614	99380	3H-NMS	64	Rat	Binding	pKi	=	5	5.0	-512	15	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
	3663	99965	3H-QNB	83	Human	Binding	pKi	=	5	5.0	-288	29	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
	CHEMBL286494	99965	3H-QNB	83	Human	Binding	pKi	=	5	5.0	-288	29	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
	37632	111590	3H-QNB	28	Human	Binding	pKi	=	5	5.0	-1	8	NoneNone	PDSP KiDatabase	351	3	0	5	3.3	CN(C)Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
	CHEMBL328250	111590	3H-QNB	28	Human	Binding	pKi	=	5	5.0	-1	8	NoneNone	PDSP KiDatabase	351	3	0	5	3.3	CN(C)Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
	3452843	119523	3H-NMS	15	Rat	Binding	pKi	=	5	5.0	-1	10	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
	CHEMBL345686	119523	3H-NMS	15	Rat	Binding	pKi	=	5	5.0	-1	10	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
	446220	133519	3H-QNB	14	Human	Binding	pKi	=	5	5.0	-1778	46	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
	CHEMBL370805	133519	3H-QNB	14	Human	Binding	pKi	=	5	5.0	-1778	46	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
	44208932	140705	UNDEFINED	7	Human	Binding	pKi	=	5	5.0	-89125	37	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
	CHEMBL381689	140705	UNDEFINED	7	Human	Binding	pKi	=	5	5.0	-89125	37	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
	1615	167789	3H-QNB	24	Human	Binding	pKi	=	5	5.0	-26	45	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	CHEMBL43048	167789	3H-QNB	24	Human	Binding	pKi	=	5	5.0	-26	45	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	5280343	188273	3H-QNB	124	Human	Binding	pKi	=	5	5.0	-147	32	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL1520590	188273	3H-QNB	124	Human	Binding	pKi	=	5	5.0	-147	32	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL50	188273	3H-QNB	124	Human	Binding	pKi	=	5	5.0	-147	32	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	3672	192531	3H-QNB	136	Human	Binding	pKi	=	5	5.0	-1	28	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
	CHEMBL521	192531	3H-QNB	136	Human	Binding	pKi	=	5	5.0	-1	28	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
	54676228	193613	3H-QNB	112	Human	Binding	pKi	=	5	5.0	-1	28	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
	CHEMBL527	193613	3H-QNB	112	Human	Binding	pKi	=	5	5.0	-1	28	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
	4495	196533	3H-QNB	92	Human	Binding	pKi	=	5	5.0	-1	30	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	CHEMBL56367	196533	3H-QNB	92	Human	Binding	pKi	=	5	5.0	-1	30	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	54677470	200549	3H-QNB	115	Human	Binding	pKi	=	5	5.0	-1	30	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL1256873	200549	3H-QNB	115	Human	Binding	pKi	=	5	5.0	-1	30	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL599	200549	3H-QNB	115	Human	Binding	pKi	=	5	5.0	-1	30	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	162265	202272	3H-QNB	22	Human	Binding	pKi	=	5	5.0	-239	45	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	4786	202272	3H-QNB	22	Human	Binding	pKi	=	5	5.0	-239	45	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	CHEMBL61006	202272	3H-QNB	22	Human	Binding	pKi	=	5	5.0	-239	45	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	5281600	203023	3H-QNB	92	Human	Binding	pKi	=	5	5.0	-275	33	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	CHEMBL63354	203023	3H-QNB	92	Human	Binding	pKi	=	5	5.0	-275	33	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	5656	203064	3H-QNB	87	Human	Binding	pKi	=	5	5.0	-25	43	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	CHEMBL637	203064	3H-QNB	87	Human	Binding	pKi	=	5	5.0	-25	43	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	1973	203481	3H-AF-DX384	15	Rat	Binding	pKi	=	5	5.0	-3	37	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	CHEMBL1394464	203481	3H-AF-DX384	15	Rat	Binding	pKi	=	5	5.0	-3	37	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	CHEMBL66089	203481	3H-AF-DX384	15	Rat	Binding	pKi	=	5	5.0	-3	37	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	202478	204685	3H-QNB	20	Human	Binding	pKi	=	5	5.0	-97	26	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
	CHEMBL7393	204685	3H-QNB	20	Human	Binding	pKi	=	5	5.0	-97	26	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
	5311189	204839	3H-QNB	11	Human	Binding	pKi	=	5	5.0	-194	28	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
	CHEMBL7549	204839	3H-QNB	11	Human	Binding	pKi	=	5	5.0	-194	28	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
	4158	205339	3H-QNB	21	Human	Binding	pKi	=	5	5.0	-141	21	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL1722	205339	3H-QNB	21	Human	Binding	pKi	=	5	5.0	-141	21	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL796	205339	3H-QNB	21	Human	Binding	pKi	=	5	5.0	-141	21	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	4054	205499	3H-QNB	72	Human	Binding	pKi	=	5	5.0	-1	37	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL1699	205499	3H-QNB	72	Human	Binding	pKi	=	5	5.0	-1	37	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL807	205499	3H-QNB	72	Human	Binding	pKi	=	5	5.0	-1	37	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	119607	206201	3H-QNB	113	Human	Binding	pKi	=	5	5.0	-97	28	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	CHEMBL865	206201	3H-QNB	113	Human	Binding	pKi	=	5	5.0	-97	28	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	3337	206365	3H-QNB	27	Human	Binding	pKi	=	5	5.0	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206365	3H-QNB	27	Human	Binding	pKi	=	5	5.0	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206365	3H-QNB	27	Human	Binding	pKi	=	5	5.0	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206365	3H-QNB	27	Human	Binding	pKi	=	5	5.0	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206365	3H-QNB	27	Human	Binding	pKi	=	5	5.0	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	DB00574	206365	3H-QNB	27	Human	Binding	pKi	=	5	5.0	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	444	206664	3H-QNB	53	Human	Binding	pKi	=	5	5.0	-2089	18	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
	CHEMBL894	206664	3H-QNB	53	Human	Binding	pKi	=	5	5.0	-2089	18	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
	16231	207507	3H-NMS	57	Rat	Binding	pKi	=	5	5.0	-7	17	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
	CHEMBL945	207507	3H-NMS	57	Rat	Binding	pKi	=	5	5.0	-7	17	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
	5831	215961	3H-NMS	0	Human	Binding	pKi	=	5	5.0	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	3H-NMS	0	Human	Binding	pKi	=	5	5.0	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	3H-NMS	0	Human	Binding	pKi	=	5	5.0	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	11954259	215977	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-15135	44	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	104911	216017	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-41686	38	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
	None	216025	3H-NMS	0	Rat	Binding	pKi	=	5	5.0	-6309	14	NoneNone	PDSP KiDatabase	453	9	2	6	2.6	COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl	None
	24835791	216102	3H-MQNB(-)	0	Rat	Binding	pKi	=	5	5.0	-1	2	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	None	216133	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-10471	24	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
	40589	216142	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-407	8	NoneNone	PDSP KiDatabase	377	7	0	6	2.5	CCC1=NN(C(=O)N1CC)CCCN2CCN(CC2)C3=CC(=CC=C3)Cl	None
	25137849	216177	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-4	41	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	71290	216177	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-4	41	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	None	216237	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-95499	30	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
	None	216309	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	34	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
	None	216310	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	34	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
	None	216311	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	34	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
	None	216312	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	34	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
	None	216313	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	29	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
	None	216314	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	40	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
	None	216315	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	39	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
	None	216316	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	30	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
	None	216323	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-13	41	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
	1576	216324	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-16	41	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
	None	216325	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-16	28	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
	4978	216326	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-16	28	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
	None	216327	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-3	28	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
	None	216328	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-281	28	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
	None	216329	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	28	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
	135269	216387	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	30	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
	23681059	216388	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	29	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
	5018304	216389	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	29	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
	84003	216390	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	28	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
	119828	216392	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-1	30	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
	None	216393	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-7	29	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
	None	216487	3H-QNB	0	Human	Binding	pKi	=	5	5.0	-4570	27	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
	None	216491	3H-NMS	0	Rat	Binding	pKi	=	5	5.0	-10471285	17	NoneNone	PDSP KiDatabase	372	2	1	3	4.4	CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl	None
	None	216492	3H-NMS	0	Human	Binding	pKi	=	5	5.0	-1	14	NoneNone	PDSP KiDatabase	399	7	4	5	1.8	CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O	None
	20980871	216428	3H-QNB	0	Human	Binding	pKi	=	7.0	7.0	-27	8	NoneNone	PDSP KiDatabase	295	3	0	2	4.7	CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31	None
	3155	216428	3H-QNB	0	Human	Binding	pKi	=	7.0	7.0	-27	8	NoneNone	PDSP KiDatabase	295	3	0	2	4.7	CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31	None
	CHEMBL108947	216428	3H-QNB	0	Human	Binding	pKi	=	7.0	7.0	-27	8	NoneNone	PDSP KiDatabase	295	3	0	2	4.7	CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31	None
	CHEMBL1492500	216428	3H-QNB	0	Human	Binding	pKi	=	7.0	7.0	-27	8	NoneNone	PDSP KiDatabase	295	3	0	2	4.7	CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31	None
	DB09167	216428	3H-QNB	0	Human	Binding	pKi	=	7.0	7.0	-27	8	NoneNone	PDSP KiDatabase	295	3	0	2	4.7	CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31	None
	367	3822	None	12	Human	Binding	pKi	=	8.0	8.0	-2	8	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	5487427	3822	None	12	Human	Binding	pKi	=	8.0	8.0	-2	8	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	8592	3822	None	12	Human	Binding	pKi	=	8.0	8.0	-2	8	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	8.0	8.0	-2	8	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	8.0	8.0	-2	8	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	8.0	8.0	-2	8	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	DB01409	3822	None	12	Human	Binding	pKi	=	8.0	8.0	-2	8	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	9399	216104	3H-MQNB(-)	0	Human	Binding	pKi	=	8.0	8.0	-	1	NoneNone	PDSP KiDatabase	493	3	2	4	-1.1	C[N+]1(CCOC(C1)(C2=CC=C(C=C2)C3=CC=C(C=C3)C4(C[N+](CCO4)(C)C)O)O)C.[Br-]	None
	180	401	3H-QNB	56	Human	Binding	pKi	=	7.9	7.9	-27	40	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	401	3H-QNB	56	Human	Binding	pKi	=	7.9	7.9	-27	40	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	401	3H-QNB	56	Human	Binding	pKi	=	7.9	7.9	-27	40	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	401	3H-QNB	56	Human	Binding	pKi	=	7.9	7.9	-27	40	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	401	3H-QNB	56	Human	Binding	pKi	=	7.9	7.9	-27	40	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	1971	2864	3H-QNB	38	Human	Binding	pKi	=	7.0	7.0	-9	30	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	2404	2864	3H-QNB	38	Human	Binding	pKi	=	7.0	7.0	-9	30	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	4543	2864	3H-QNB	38	Human	Binding	pKi	=	7.0	7.0	-9	30	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	CHEMBL445	2864	3H-QNB	38	Human	Binding	pKi	=	7.0	7.0	-9	30	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	DB00540	2864	3H-QNB	38	Human	Binding	pKi	=	7.0	7.0	-9	30	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	44431388	87317	UNDEFINED	0	Human	Binding	pKi	=	7.9	7.9	-2	3	NoneNone	PDSP KiDatabase	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	None
	CHEMBL233202	87317	UNDEFINED	0	Human	Binding	pKi	=	7.9	7.9	-2	3	NoneNone	PDSP KiDatabase	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	None
	44431380	87983	UNDEFINED	0	Human	Binding	pKi	=	7.9	7.9	-2	3	NoneNone	PDSP KiDatabase	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	None
	CHEMBL234257	87983	UNDEFINED	0	Human	Binding	pKi	=	7.9	7.9	-2	3	NoneNone	PDSP KiDatabase	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	None
	154825138	216036	3H-MQNB(-)	0	Human	Binding	pKi	=	7.9	7.9	-1	12	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	154825138	216036	3H-NMS	0	Human	Binding	pKi	=	7.9	7.9	-1	12	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	154825138	216036	3H-NMS	0	Rat	Binding	pKi	=	7.9	7.9	-1	12	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	154734599	2501	3H-4-DAMP	12	Human	Binding	pKi	=	7.9	7.9	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	154734599	2501	3H-PIRENZEPINE	12	Rat	Binding	pKi	=	7.9	7.9	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-4-DAMP	12	Human	Binding	pKi	=	7.9	7.9	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-PIRENZEPINE	12	Rat	Binding	pKi	=	7.9	7.9	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-4-DAMP	12	Human	Binding	pKi	=	7.9	7.9	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-PIRENZEPINE	12	Rat	Binding	pKi	=	7.9	7.9	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-4-DAMP	12	Human	Binding	pKi	=	7.9	7.9	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-PIRENZEPINE	12	Rat	Binding	pKi	=	7.9	7.9	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	1224	1431	3H-QNB	83	Human	Binding	pKi	=	6.9	6.9	-6	13	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	3100	1431	3H-QNB	83	Human	Binding	pKi	=	6.9	6.9	-6	13	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	8980	1431	3H-QNB	83	Human	Binding	pKi	=	6.9	6.9	-6	13	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	916	1431	3H-QNB	83	Human	Binding	pKi	=	6.9	6.9	-6	13	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	CHEMBL657	1431	3H-QNB	83	Human	Binding	pKi	=	6.9	6.9	-6	13	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	DB01075	1431	3H-QNB	83	Human	Binding	pKi	=	6.9	6.9	-6	13	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	310	1920	3H-NMS	0	Rat	Binding	pKi	=	6.9	6.9	-25	11	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	3602	1920	3H-NMS	0	Rat	Binding	pKi	=	6.9	6.9	-25	11	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	CHEMBL3545990	1920	3H-NMS	0	Rat	Binding	pKi	=	6.9	6.9	-25	11	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	1353	1909	3H-NMS	93	Rat	Binding	pKi	=	5.9	5.9	-338	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1909	3H-QNB	93	Rat	Binding	pKi	=	5.9	5.9	-338	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1909	3H-NMS	93	Rat	Binding	pKi	=	5.9	5.9	-338	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1909	3H-QNB	93	Rat	Binding	pKi	=	5.9	5.9	-338	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1909	3H-NMS	93	Rat	Binding	pKi	=	5.9	5.9	-338	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1909	3H-QNB	93	Rat	Binding	pKi	=	5.9	5.9	-338	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1909	3H-NMS	93	Rat	Binding	pKi	=	5.9	5.9	-338	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1909	3H-QNB	93	Rat	Binding	pKi	=	5.9	5.9	-338	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1909	3H-NMS	93	Rat	Binding	pKi	=	5.9	5.9	-338	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1909	3H-QNB	93	Rat	Binding	pKi	=	5.9	5.9	-338	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3652	4095	3H-QNB	79	Human	Binding	pKi	=	6.9	6.9	-18	18	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4095	3H-QNB	79	Human	Binding	pKi	=	6.9	6.9	-18	18	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4095	3H-QNB	79	Human	Binding	pKi	=	6.9	6.9	-18	18	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4095	3H-QNB	79	Human	Binding	pKi	=	6.9	6.9	-18	18	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4095	3H-QNB	79	Human	Binding	pKi	=	6.9	6.9	-18	18	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	None	216255	3H-4-DAMP	0	Human	Binding	pKi	=	6.9	6.9	-8	5	NoneNone	PDSP KiDatabase	851	24	12	12	-2.6	CCC(C)C(C(=O)NC(CC(=O)O)C(=O)O)NC(=O)C(CO)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCN4	None
	1734	116	3H-NMS	10	Rat	Binding	pKi	=	7.9	7.9	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	3H-NMS	10	Rat	Binding	pKi	=	7.9	7.9	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	3H-NMS	10	Rat	Binding	pKi	=	7.9	7.9	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	154734599	2501	3H-NMS	12	Human	Binding	pKi	=	7.9	7.9	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-NMS	12	Human	Binding	pKi	=	7.9	7.9	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-NMS	12	Human	Binding	pKi	=	7.9	7.9	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-NMS	12	Human	Binding	pKi	=	7.9	7.9	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	2745	3859	3H-NMS	42	Rat	Binding	pKi	=	7.9	7.9	-18	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	5572	3859	3H-NMS	42	Rat	Binding	pKi	=	7.9	7.9	-18	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	66007	3859	3H-NMS	42	Rat	Binding	pKi	=	7.9	7.9	-18	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	7315	3859	3H-NMS	42	Rat	Binding	pKi	=	7.9	7.9	-18	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	CHEMBL1490	3859	3H-NMS	42	Rat	Binding	pKi	=	7.9	7.9	-18	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	DB00376	3859	3H-NMS	42	Rat	Binding	pKi	=	7.9	7.9	-18	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	None	216255	3H-NMS	0	Human	Binding	pKi	=	6.9	6.9	-8	5	NoneNone	PDSP KiDatabase	851	24	12	12	-2.6	CCC(C)C(C(=O)NC(CC(=O)O)C(=O)O)NC(=O)C(CO)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCN4	None
	2337	3254	3H-QNB	77	Human	Binding	pKi	=	5.9	5.9	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3254	3H-QNB	77	Human	Binding	pKi	=	5.9	5.9	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3254	3H-QNB	77	Human	Binding	pKi	=	5.9	5.9	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3254	3H-QNB	77	Human	Binding	pKi	=	5.9	5.9	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3254	3H-QNB	77	Human	Binding	pKi	=	5.9	5.9	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	135398737	957	3H-QNB	93	Human	Binding	pKi	=	7.9	7.9	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	957	3H-QNB	93	Human	Binding	pKi	=	7.9	7.9	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	957	3H-QNB	93	Human	Binding	pKi	=	7.9	7.9	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	957	3H-QNB	93	Human	Binding	pKi	=	7.9	7.9	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	957	3H-QNB	93	Human	Binding	pKi	=	7.9	7.9	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	100	3803	3H-QNB	58	Human	Binding	pKi	=	7.9	7.9	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3803	3H-QNB	58	Human	Binding	pKi	=	7.9	7.9	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3803	3H-QNB	58	Human	Binding	pKi	=	7.9	7.9	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3803	3H-QNB	58	Human	Binding	pKi	=	7.9	7.9	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3803	3H-QNB	58	Human	Binding	pKi	=	7.9	7.9	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	4066	204624	3H-QNB	78	Human	Binding	pKi	=	7.9	7.9	-1	7	NoneNone	PDSP KiDatabase	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
	CHEMBL73451	204624	3H-QNB	78	Human	Binding	pKi	=	7.9	7.9	-1	7	NoneNone	PDSP KiDatabase	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
	DB01071	204624	3H-QNB	78	Human	Binding	pKi	=	7.9	7.9	-1	7	NoneNone	PDSP KiDatabase	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
	154825138	216036	3H-MQNB(-)	0	Rat	Binding	pKi	=	7.9	7.9	-1	12	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	154734599	2501	3H-NMS	12	Human	Binding	pKi	=	7.8	7.8	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-NMS	12	Human	Binding	pKi	=	7.8	7.8	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-NMS	12	Human	Binding	pKi	=	7.8	7.8	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-NMS	12	Human	Binding	pKi	=	7.8	7.8	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	103	4151	3H-QNB	61	Human	Binding	pKi	=	6.9	6.9	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4151	3H-QNB	61	Human	Binding	pKi	=	6.9	6.9	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4151	3H-QNB	61	Human	Binding	pKi	=	6.9	6.9	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4151	3H-QNB	61	Human	Binding	pKi	=	6.9	6.9	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4151	3H-QNB	61	Human	Binding	pKi	=	6.9	6.9	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	103	4151	3H-QNB	61	Human	Binding	pKi	=	6.9	6.9	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4151	3H-QNB	61	Human	Binding	pKi	=	6.9	6.9	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4151	3H-QNB	61	Human	Binding	pKi	=	6.9	6.9	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4151	3H-QNB	61	Human	Binding	pKi	=	6.9	6.9	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4151	3H-QNB	61	Human	Binding	pKi	=	6.9	6.9	-177	54	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	4601	206745	3H-NMS	35	Rat	Binding	pKi	=	6.9	6.9	-6	17	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL1201023	206745	3H-NMS	35	Rat	Binding	pKi	=	6.9	6.9	-6	17	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL900	206745	3H-NMS	35	Rat	Binding	pKi	=	6.9	6.9	-6	17	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	DB01173	206745	3H-NMS	35	Rat	Binding	pKi	=	6.9	6.9	-6	17	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	4839	216373	3H-NMS	0	Rat	Binding	pKi	=	6.9	6.9	-3	5	NoneNone	PDSP KiDatabase	323	5	0	3	3.8	CCN1CCCC(C1)OC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3	None
	2274	3171	3H-QNB	58	Human	Binding	pKi	=	5.9	5.9	-100	32	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3171	3H-QNB	58	Human	Binding	pKi	=	5.9	5.9	-100	32	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3171	3H-QNB	58	Human	Binding	pKi	=	5.9	5.9	-100	32	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3171	3H-QNB	58	Human	Binding	pKi	=	5.9	5.9	-100	32	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3171	3H-QNB	58	Human	Binding	pKi	=	5.9	5.9	-100	32	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	1712	2490	3H-QNB	43	Human	Binding	pKi	=	7.8	7.8	-5	22	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	4078	2490	3H-QNB	43	Human	Binding	pKi	=	7.8	7.8	-5	22	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	7227	2490	3H-QNB	43	Human	Binding	pKi	=	7.8	7.8	-5	22	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	CHEMBL1088	2490	3H-QNB	43	Human	Binding	pKi	=	7.8	7.8	-5	22	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	DB00933	2490	3H-QNB	43	Human	Binding	pKi	=	7.8	7.8	-5	22	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	154825138	216036	3H-NMS	0	Rat	Binding	pKi	=	7.8	7.8	-1	12	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	2270	3169	3H-MQNB(-)	69	Human	Binding	pKi	=	7.8	7.8	-	1	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	4811	3169	3H-MQNB(-)	69	Human	Binding	pKi	=	7.8	7.8	-	1	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	4913	3169	3H-MQNB(-)	69	Human	Binding	pKi	=	7.8	7.8	-	1	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	CHEMBL640	3169	3H-MQNB(-)	69	Human	Binding	pKi	=	7.8	7.8	-	1	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	DB01035	3169	3H-MQNB(-)	69	Human	Binding	pKi	=	7.8	7.8	-	1	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	2726	918	3H-QNB	68	Human	Binding	pKi	=	6.8	6.8	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	918	3H-QNB	68	Human	Binding	pKi	=	6.8	6.8	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	918	3H-QNB	68	Human	Binding	pKi	=	6.8	6.8	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	918	3H-QNB	68	Human	Binding	pKi	=	6.8	6.8	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	918	3H-QNB	68	Human	Binding	pKi	=	6.8	6.8	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	3012003	216143	3H-QNB	0	Human	Binding	pKi	=	6.8	6.8	-1	12	NoneNone	PDSP KiDatabase	311	5	0	3	3.8	CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3	None
	308	2058	3H-MQNB(-)	23	Human	Binding	pKi	=	6.8	6.8	-11	9	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	3603	2058	3H-MQNB(-)	23	Human	Binding	pKi	=	6.8	6.8	-11	9	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	CHEMBL1256682	2058	3H-MQNB(-)	23	Human	Binding	pKi	=	6.8	6.8	-11	9	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	154734599	2501	3H-QNB	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-QNB	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-QNB	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-QNB	12	Rat	Binding	pKi	=	7.8	7.8	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	5387	94877	3H-NMS	31	Rat	Binding	pKi	=	7.8	7.8	-19	6	NoneNone	PDSP KiDatabase	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	None
	CHEMBL253978	94877	3H-NMS	31	Rat	Binding	pKi	=	7.8	7.8	-19	6	NoneNone	PDSP KiDatabase	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	None
	1225	1470	3H-QNB	26	Human	Binding	pKi	=	6.8	6.8	-117	22	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	1470	3H-QNB	26	Human	Binding	pKi	=	6.8	6.8	-117	22	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667468	1470	3H-QNB	26	Human	Binding	pKi	=	6.8	6.8	-117	22	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	1470	3H-QNB	26	Human	Binding	pKi	=	6.8	6.8	-117	22	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL101740	1470	3H-QNB	26	Human	Binding	pKi	=	6.8	6.8	-117	22	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	1470	3H-QNB	26	Human	Binding	pKi	=	6.8	6.8	-117	22	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	1470	3H-QNB	26	Human	Binding	pKi	=	6.8	6.8	-117	22	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	73707487	216372	3H-NMS	0	Rat	Binding	pKi	=	6.8	6.8	-23	9	NoneNone	PDSP KiDatabase	355	3	1	4	2.5	CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br	None
	1273	1752	3H-MQNB(-)	16	Human	Binding	pKi	=	5.8	5.8	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1752	3H-MQNB(-)	16	Human	Binding	pKi	=	5.8	5.8	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1752	3H-MQNB(-)	16	Human	Binding	pKi	=	5.8	5.8	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1752	3H-MQNB(-)	16	Human	Binding	pKi	=	5.8	5.8	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1752	3H-MQNB(-)	16	Human	Binding	pKi	=	5.8	5.8	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1752	3H-MQNB(-)	16	Human	Binding	pKi	=	5.8	5.8	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1752	3H-MQNB(-)	16	Human	Binding	pKi	=	5.8	5.8	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	308	2058	3H-MQNB(-)	23	Rat	Binding	pKi	=	6.8	6.8	-10	9	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	3603	2058	3H-MQNB(-)	23	Rat	Binding	pKi	=	6.8	6.8	-10	9	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	CHEMBL1256682	2058	3H-MQNB(-)	23	Rat	Binding	pKi	=	6.8	6.8	-10	9	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	277	1300	3H-QNB	62	Human	Binding	pKi	=	7.7	7.7	-12	50	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1300	3H-QNB	62	Human	Binding	pKi	=	7.7	7.7	-12	50	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1300	3H-QNB	62	Human	Binding	pKi	=	7.7	7.7	-12	50	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1300	3H-QNB	62	Human	Binding	pKi	=	7.7	7.7	-12	50	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1300	3H-QNB	62	Human	Binding	pKi	=	7.7	7.7	-12	50	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	135398745	2912	3H-NMS	112	Rat	Binding	pKi	=	7.7	7.7	-9	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2912	3H-QNB	112	Rat	Binding	pKi	=	7.7	7.7	-9	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2912	3H-NMS	112	Rat	Binding	pKi	=	7.7	7.7	-9	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2912	3H-QNB	112	Rat	Binding	pKi	=	7.7	7.7	-9	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2912	3H-NMS	112	Rat	Binding	pKi	=	7.7	7.7	-9	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2912	3H-QNB	112	Rat	Binding	pKi	=	7.7	7.7	-9	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2912	3H-NMS	112	Rat	Binding	pKi	=	7.7	7.7	-9	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2912	3H-QNB	112	Rat	Binding	pKi	=	7.7	7.7	-9	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	101	3820	3H-QNB	24	Human	Binding	pKi	=	6.7	6.7	-741	14	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	55752	3820	3H-QNB	24	Human	Binding	pKi	=	6.7	6.7	-741	14	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL35057	3820	3H-QNB	24	Human	Binding	pKi	=	6.7	6.7	-741	14	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	2448	99321	3H-QNB	70	Human	Binding	pKi	=	5.7	5.7	-72	18	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	CHEMBL28218	99321	3H-QNB	70	Human	Binding	pKi	=	5.7	5.7	-72	18	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	DB12401	99321	3H-QNB	70	Human	Binding	pKi	=	5.7	5.7	-72	18	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	2448	99321	3H-QNB	70	Human	Binding	pKi	=	5.7	5.7	-72	18	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	CHEMBL28218	99321	3H-QNB	70	Human	Binding	pKi	=	5.7	5.7	-72	18	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	DB12401	99321	3H-QNB	70	Human	Binding	pKi	=	5.7	5.7	-72	18	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	5831	215961	3H-MQNB(-)	0	Human	Binding	pKi	=	5.7	5.7	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	3H-MQNB(-)	0	Human	Binding	pKi	=	5.7	5.7	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	3H-MQNB(-)	0	Human	Binding	pKi	=	5.7	5.7	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	3337	206365	3H-QNB	27	Human	Binding	pKi	=	5.7	5.7	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206365	3H-QNB	27	Human	Binding	pKi	=	5.7	5.7	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206365	3H-QNB	27	Human	Binding	pKi	=	5.7	5.7	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206365	3H-QNB	27	Human	Binding	pKi	=	5.7	5.7	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206365	3H-QNB	27	Human	Binding	pKi	=	5.7	5.7	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	DB00574	206365	3H-QNB	27	Human	Binding	pKi	=	5.7	5.7	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	154734599	2501	3H-NMS	12	Rat	Binding	pKi	=	7.7	7.7	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-NMS	12	Rat	Binding	pKi	=	7.7	7.7	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-NMS	12	Rat	Binding	pKi	=	7.7	7.7	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-NMS	12	Rat	Binding	pKi	=	7.7	7.7	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	None	216252	3H-NMS	0	Rat	Binding	pKi	=	5.7	5.7	-1659	21	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
	2200	3129	3H-4-DAMP	46	Human	Binding	pKi	=	6.7	6.7	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-4-DAMP	46	Human	Binding	pKi	=	6.7	6.7	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-4-DAMP	46	Human	Binding	pKi	=	6.7	6.7	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-4-DAMP	46	Human	Binding	pKi	=	6.7	6.7	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-4-DAMP	46	Human	Binding	pKi	=	6.7	6.7	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	44431383	88020	UNDEFINED	0	Human	Binding	pKi	=	8.7	8.7	1	3	NoneNone	PDSP KiDatabase	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	None
	CHEMBL234439	88020	UNDEFINED	0	Human	Binding	pKi	=	8.7	8.7	1	3	NoneNone	PDSP KiDatabase	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	None
	131632304	216035	3H-QNB	0	Human	Binding	pKi	=	8.7	8.7	-6	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	5184	216035	3H-QNB	0	Human	Binding	pKi	=	8.7	8.7	-6	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	CHEMBL13030	216035	3H-QNB	0	Human	Binding	pKi	=	8.7	8.7	-6	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	DB00747	216035	3H-QNB	0	Human	Binding	pKi	=	8.7	8.7	-6	13	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	2230	465	3H-QNB	60	Human	Binding	pKi	=	8.6	8.6	-75	10	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	296	465	3H-QNB	60	Human	Binding	pKi	=	8.6	8.6	-75	10	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	CHEMBL7303	465	3H-QNB	60	Human	Binding	pKi	=	8.6	8.6	-75	10	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	DB04365	465	3H-QNB	60	Human	Binding	pKi	=	8.6	8.6	-75	10	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	44431381	149019	UNDEFINED	0	Human	Binding	pKi	=	8.6	8.6	1	3	NoneNone	PDSP KiDatabase	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	None
	CHEMBL394254	149019	UNDEFINED	0	Human	Binding	pKi	=	8.6	8.6	1	3	NoneNone	PDSP KiDatabase	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	None
	None	216254	3H-NMS	0	Human	Binding	pKi	=	7.7	7.7	-5	5	NoneNone	PDSP KiDatabase	311	3	1	2	3.9	C1CCC(CC1)C(C#CCN2CCCCC2)(C3=CC=CC=C3)O	None
	124226	1919	3H-NMS	0	Human	Binding	pKi	=	6.7	6.7	-19	5	NoneNone	PDSP KiDatabase	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	322	1919	3H-NMS	0	Human	Binding	pKi	=	6.7	6.7	-19	5	NoneNone	PDSP KiDatabase	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	5831	215961	3H-MQNB(-)	0	Rat	Binding	pKi	=	5.7	5.7	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	3H-MQNB(-)	0	Rat	Binding	pKi	=	5.7	5.7	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	3H-MQNB(-)	0	Rat	Binding	pKi	=	5.7	5.7	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	135398737	957	3H-NMS	93	Human	Binding	pKi	=	6.7	6.7	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	957	3H-NMSP	93	Human	Binding	pKi	=	6.7	6.7	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	957	3H-NMS	93	Human	Binding	pKi	=	6.7	6.7	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	957	3H-NMSP	93	Human	Binding	pKi	=	6.7	6.7	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	957	3H-NMS	93	Human	Binding	pKi	=	6.7	6.7	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	957	3H-NMSP	93	Human	Binding	pKi	=	6.7	6.7	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	957	3H-NMS	93	Human	Binding	pKi	=	6.7	6.7	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	957	3H-NMSP	93	Human	Binding	pKi	=	6.7	6.7	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	957	3H-NMS	93	Human	Binding	pKi	=	6.7	6.7	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	957	3H-NMSP	93	Human	Binding	pKi	=	6.7	6.7	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	5831	215961	3H-MQNB(-)	0	Rat	Binding	pKi	=	5.7	5.7	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	3H-MQNB(-)	0	Rat	Binding	pKi	=	5.7	5.7	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	3H-MQNB(-)	0	Rat	Binding	pKi	=	5.7	5.7	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	68617	205525	3H-QNB	62	Human	Binding	pKi	=	5.7	5.7	-32	26	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL1709	205525	3H-QNB	62	Human	Binding	pKi	=	5.7	5.7	-32	26	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL809	205525	3H-QNB	62	Human	Binding	pKi	=	5.7	5.7	-32	26	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	11954259	215977	3H-QNB	0	Human	Binding	pKi	=	5.7	5.7	-15135	44	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	4601	206745	3H-QNB	35	Human	Binding	pKi	=	6.7	6.7	-2	17	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL1201023	206745	3H-QNB	35	Human	Binding	pKi	=	6.7	6.7	-2	17	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL900	206745	3H-QNB	35	Human	Binding	pKi	=	6.7	6.7	-2	17	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	DB01173	206745	3H-QNB	35	Human	Binding	pKi	=	6.7	6.7	-2	17	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	2726	918	3H-MQNB(-)	68	Human	Binding	pKi	=	6.7	6.7	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	918	3H-MQNB(-)	68	Human	Binding	pKi	=	6.7	6.7	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	918	3H-MQNB(-)	68	Human	Binding	pKi	=	6.7	6.7	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	918	3H-MQNB(-)	68	Human	Binding	pKi	=	6.7	6.7	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	918	3H-MQNB(-)	68	Human	Binding	pKi	=	6.7	6.7	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	1212	1660	3H-QNB	50	Human	Binding	pKi	=	5.7	5.7	-1380	66	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1660	3H-QNB	50	Human	Binding	pKi	=	5.7	5.7	-1380	66	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1660	3H-QNB	50	Human	Binding	pKi	=	5.7	5.7	-1380	66	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1660	3H-QNB	50	Human	Binding	pKi	=	5.7	5.7	-1380	66	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1660	3H-QNB	50	Human	Binding	pKi	=	5.7	5.7	-1380	66	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	214	3858	3H-QNB	58	Human	Binding	pKi	=	5.7	5.7	-2630	30	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3858	3H-QNB	58	Human	Binding	pKi	=	5.7	5.7	-2630	30	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3858	3H-QNB	58	Human	Binding	pKi	=	5.7	5.7	-2630	30	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3858	3H-QNB	58	Human	Binding	pKi	=	5.7	5.7	-2630	30	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3858	3H-QNB	58	Human	Binding	pKi	=	5.7	5.7	-2630	30	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3858	3H-QNB	58	Human	Binding	pKi	=	5.7	5.7	-2630	30	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2200	3129	3H-QNB	46	Rat	Binding	pKi	=	6.7	6.7	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-QNB	46	Rat	Binding	pKi	=	6.7	6.7	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-QNB	46	Rat	Binding	pKi	=	6.7	6.7	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-QNB	46	Rat	Binding	pKi	=	6.7	6.7	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-QNB	46	Rat	Binding	pKi	=	6.7	6.7	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	2200	3129	3H-NMS	46	Human	Binding	pKi	=	6.7	6.7	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-NMS	46	Human	Binding	pKi	=	6.7	6.7	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-NMS	46	Human	Binding	pKi	=	6.7	6.7	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-NMS	46	Human	Binding	pKi	=	6.7	6.7	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-NMS	46	Human	Binding	pKi	=	6.7	6.7	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	1979	77324	3H-cAMP	70	Human	Binding	pKi	=	5.7	5.7	-2	4	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77324	3H-cAMP	70	Human	Binding	pKi	=	5.7	5.7	-2	4	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	302	2975	3H-MQNB(-)	25	Human	Binding	pKi	=	6.6	6.6	-34	8	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	4630	2975	3H-MQNB(-)	25	Human	Binding	pKi	=	6.6	6.6	-34	8	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	CHEMBL7634	2975	3H-MQNB(-)	25	Human	Binding	pKi	=	6.6	6.6	-34	8	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	15387	45820	3H-QNB	55	Human	Binding	pKi	=	5.6	5.6	-16	24	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	CHEMBL1531134	45820	3H-QNB	55	Human	Binding	pKi	=	5.6	5.6	-16	24	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	15387	45820	3H-QNB	55	Human	Binding	pKi	=	5.6	5.6	-16	24	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	CHEMBL1531134	45820	3H-QNB	55	Human	Binding	pKi	=	5.6	5.6	-16	24	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	3042	1413	3H-NMS	35	Human	Binding	pKi	=	6.6	6.6	-28	15	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	355	1413	3H-NMS	35	Human	Binding	pKi	=	6.6	6.6	-28	15	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	868	1413	3H-NMS	35	Human	Binding	pKi	=	6.6	6.6	-28	15	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	CHEMBL1123	1413	3H-NMS	35	Human	Binding	pKi	=	6.6	6.6	-28	15	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	DB00804	1413	3H-NMS	35	Human	Binding	pKi	=	6.6	6.6	-28	15	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	5831	215961	3H-cAMP	0	Rat	Binding	pKi	=	5.6	5.6	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	3H-cAMP	0	Rat	Binding	pKi	=	5.6	5.6	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	3H-cAMP	0	Rat	Binding	pKi	=	5.6	5.6	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	310	1920	3H-NMS	0	Human	Binding	pKi	=	6.6	6.6	-56	11	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	3602	1920	3H-NMS	0	Human	Binding	pKi	=	6.6	6.6	-56	11	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	CHEMBL3545990	1920	3H-NMS	0	Human	Binding	pKi	=	6.6	6.6	-56	11	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	10921	13043	3H-MQNB(-)	23	Human	Binding	pKi	=	7.6	7.6	-	1	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	2968	13043	3H-MQNB(-)	23	Human	Binding	pKi	=	7.6	7.6	-	1	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	CHEMBL1190	13043	3H-MQNB(-)	23	Human	Binding	pKi	=	7.6	7.6	-	1	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	4919	206232	3H-QNB	23	Human	Binding	pKi	=	7.6	7.6	-3	9	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	CHEMBL86715	206232	3H-QNB	23	Human	Binding	pKi	=	7.6	7.6	-3	9	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	DB00387	206232	3H-QNB	23	Human	Binding	pKi	=	7.6	7.6	-3	9	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	2865	4141	3H-QNB	73	Human	Binding	pKi	=	5.6	5.6	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4141	3H-QNB	73	Human	Binding	pKi	=	5.6	5.6	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4141	3H-QNB	73	Human	Binding	pKi	=	5.6	5.6	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4141	3H-QNB	73	Human	Binding	pKi	=	5.6	5.6	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4141	3H-QNB	73	Human	Binding	pKi	=	5.6	5.6	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	100	3803	3H-QNB	58	Human	Binding	pKi	=	7.6	7.6	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3803	3H-QNB	58	Human	Binding	pKi	=	7.6	7.6	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3803	3H-QNB	58	Human	Binding	pKi	=	7.6	7.6	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3803	3H-QNB	58	Human	Binding	pKi	=	7.6	7.6	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3803	3H-QNB	58	Human	Binding	pKi	=	7.6	7.6	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	1273	1752	3H-MQNB(-)	16	Rat	Binding	pKi	=	5.6	5.6	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1752	3H-MQNB(-)	16	Rat	Binding	pKi	=	5.6	5.6	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1752	3H-MQNB(-)	16	Rat	Binding	pKi	=	5.6	5.6	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1752	3H-MQNB(-)	16	Rat	Binding	pKi	=	5.6	5.6	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1752	3H-MQNB(-)	16	Rat	Binding	pKi	=	5.6	5.6	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1752	3H-MQNB(-)	16	Rat	Binding	pKi	=	5.6	5.6	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1752	3H-MQNB(-)	16	Rat	Binding	pKi	=	5.6	5.6	-1	3	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	2905	14496	3H-NMS	50	Rat	Binding	pKi	=	7.6	7.6	-16	5	NoneNone	PDSP KiDatabase	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	None
	CHEMBL1201338	14496	3H-NMS	50	Rat	Binding	pKi	=	7.6	7.6	-16	5	NoneNone	PDSP KiDatabase	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	None
	DB00979	14496	3H-NMS	50	Rat	Binding	pKi	=	7.6	7.6	-16	5	NoneNone	PDSP KiDatabase	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	None
	2200	3129	3H-QNB	46	Human	Binding	pKi	=	6.6	6.6	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-QNB	46	Human	Binding	pKi	=	6.6	6.6	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-QNB	46	Human	Binding	pKi	=	6.6	6.6	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-QNB	46	Human	Binding	pKi	=	6.6	6.6	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-QNB	46	Human	Binding	pKi	=	6.6	6.6	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	1209	1656	3H-QNB	75	Human	Binding	pKi	=	5.6	5.6	-22	32	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1656	3H-QNB	75	Human	Binding	pKi	=	5.6	5.6	-22	32	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1656	3H-QNB	75	Human	Binding	pKi	=	5.6	5.6	-22	32	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1656	3H-QNB	75	Human	Binding	pKi	=	5.6	5.6	-22	32	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1656	3H-QNB	75	Human	Binding	pKi	=	5.6	5.6	-22	32	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	2726	918	3H-QNB	68	Human	Binding	pKi	=	6.6	6.6	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	918	3H-QNB	68	Human	Binding	pKi	=	6.6	6.6	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	918	3H-QNB	68	Human	Binding	pKi	=	6.6	6.6	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	918	3H-QNB	68	Human	Binding	pKi	=	6.6	6.6	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	918	3H-QNB	68	Human	Binding	pKi	=	6.6	6.6	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	11976	919	3H-QNB	59	Human	Binding	pKi	=	7.6	7.6	-23	24	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	919	3H-QNB	59	Human	Binding	pKi	=	7.6	7.6	-23	24	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	919	3H-QNB	59	Human	Binding	pKi	=	7.6	7.6	-23	24	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	919	3H-QNB	59	Human	Binding	pKi	=	7.6	7.6	-23	24	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	209	3055	3H-QNB	97	Human	Binding	pKi	=	5.5	5.5	-4073	23	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	3055	3H-QNB	97	Human	Binding	pKi	=	5.5	5.5	-4073	23	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	3055	3H-QNB	97	Human	Binding	pKi	=	5.5	5.5	-4073	23	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	3055	3H-QNB	97	Human	Binding	pKi	=	5.5	5.5	-4073	23	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	3055	3H-QNB	97	Human	Binding	pKi	=	5.5	5.5	-4073	23	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	302	2975	3H-MQNB(-)	25	Rat	Binding	pKi	=	6.5	6.5	-4	8	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	4630	2975	3H-MQNB(-)	25	Rat	Binding	pKi	=	6.5	6.5	-4	8	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	CHEMBL7634	2975	3H-MQNB(-)	25	Rat	Binding	pKi	=	6.5	6.5	-4	8	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	1192	147	3H-NMS	47	Rat	Binding	pKi	=	5.5	5.5	-46	17	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
	1794	147	3H-NMS	47	Rat	Binding	pKi	=	5.5	5.5	-46	17	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
	CHEMBL501701	147	3H-NMS	47	Rat	Binding	pKi	=	5.5	5.5	-46	17	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
	2028	2977	3H-NMS	80	Rat	Binding	pKi	=	8.5	8.5	-5	11	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	359	2977	3H-NMS	80	Rat	Binding	pKi	=	8.5	8.5	-5	11	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	4634	2977	3H-NMS	80	Rat	Binding	pKi	=	8.5	8.5	-5	11	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	CHEMBL1231	2977	3H-NMS	80	Rat	Binding	pKi	=	8.5	8.5	-5	11	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	DB01062	2977	3H-NMS	80	Rat	Binding	pKi	=	8.5	8.5	-5	11	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	154734599	2501	3H-NMS	12	Human	Binding	pKi	=	8.4	8.4	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-NMS	12	Human	Binding	pKi	=	8.4	8.4	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-NMS	12	Human	Binding	pKi	=	8.4	8.4	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-NMS	12	Human	Binding	pKi	=	8.4	8.4	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	1734	116	3H-QNB	10	Rat	Binding	pKi	=	8.4	8.4	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	3H-QNB	10	Rat	Binding	pKi	=	8.4	8.4	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	3H-QNB	10	Rat	Binding	pKi	=	8.4	8.4	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	1734	116	3H-NMS	10	Human	Binding	pKi	=	8.4	8.4	-9	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	3H-NMS	10	Human	Binding	pKi	=	8.4	8.4	-9	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	3H-NMS	10	Human	Binding	pKi	=	8.4	8.4	-9	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	3246155	215960	3H-NMS	0	Rat	Binding	pKi	=	8.4	8.4	-16	17	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
	1734	116	3H-4-DAMP	10	Human	Binding	pKi	=	8.4	8.4	-9	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	3H-4-DAMP	10	Human	Binding	pKi	=	8.4	8.4	-9	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	3H-4-DAMP	10	Human	Binding	pKi	=	8.4	8.4	-9	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	308	2058	3H-NMS	23	Rat	Binding	pKi	=	6.5	6.5	-10	9	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	3603	2058	3H-NMS	23	Rat	Binding	pKi	=	6.5	6.5	-10	9	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	CHEMBL1256682	2058	3H-NMS	23	Rat	Binding	pKi	=	6.5	6.5	-10	9	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	1613	2346	3H-QNB	53	Human	Binding	pKi	=	6.5	6.5	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2346	3H-QNB	53	Human	Binding	pKi	=	6.5	6.5	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2346	3H-QNB	53	Human	Binding	pKi	=	6.5	6.5	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2346	3H-QNB	53	Human	Binding	pKi	=	6.5	6.5	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2346	3H-QNB	53	Human	Binding	pKi	=	6.5	6.5	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	2865	4141	3H-QNB	73	Human	Binding	pKi	=	5.5	5.5	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4141	3H-QNB	73	Human	Binding	pKi	=	5.5	5.5	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4141	3H-QNB	73	Human	Binding	pKi	=	5.5	5.5	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4141	3H-QNB	73	Human	Binding	pKi	=	5.5	5.5	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4141	3H-QNB	73	Human	Binding	pKi	=	5.5	5.5	-1659	54	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	3042	1413	3H-NMS	35	Rat	Binding	pKi	=	7.5	7.5	-12	15	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	355	1413	3H-NMS	35	Rat	Binding	pKi	=	7.5	7.5	-12	15	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	868	1413	3H-NMS	35	Rat	Binding	pKi	=	7.5	7.5	-12	15	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	CHEMBL1123	1413	3H-NMS	35	Rat	Binding	pKi	=	7.5	7.5	-12	15	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	DB00804	1413	3H-NMS	35	Rat	Binding	pKi	=	7.5	7.5	-12	15	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	7534	216371	3H-NMS	0	Rat	Binding	pKi	=	6.5	6.5	-3	5	NoneNone	PDSP KiDatabase	291	3	1	4	2.5	CC1CC(CC(N1C)(C)C)OC(=O)C(C2=CC=CC=C2)O	None
	3947	206393	3H-QNB	53	Human	Binding	pKi	=	6.5	6.5	-6	16	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
	CHEMBL87708	206393	3H-QNB	53	Human	Binding	pKi	=	6.5	6.5	-6	16	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
	114743	216099	3H-QNB	0	Human	Binding	pKi	=	5.5	5.5	-1	8	NoneNone	PDSP KiDatabase	291	1	1	1	4.9	C1CC(C2=CC=CC=C2C1C3=CC(=C(C=C3)Cl)Cl)N	None
	2200	3129	3H-NMS	46	Rat	Binding	pKi	=	6.5	6.5	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-NMS	46	Rat	Binding	pKi	=	6.5	6.5	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-NMS	46	Rat	Binding	pKi	=	6.5	6.5	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-NMS	46	Rat	Binding	pKi	=	6.5	6.5	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-NMS	46	Rat	Binding	pKi	=	6.5	6.5	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	5831	215961	3H-cAMP	0	Human	Binding	pKi	=	6.5	6.5	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	3H-cAMP	0	Human	Binding	pKi	=	6.5	6.5	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	3H-cAMP	0	Human	Binding	pKi	=	6.5	6.5	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	3294	2004	3H-NMS	111	Human	Binding	pKi	=	5.5	5.5	-194	45	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	2004	3H-NMS	111	Human	Binding	pKi	=	5.5	5.5	-194	45	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	2004	3H-NMS	111	Human	Binding	pKi	=	5.5	5.5	-194	45	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	2004	3H-NMS	111	Human	Binding	pKi	=	5.5	5.5	-194	45	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	2004	3H-NMS	111	Human	Binding	pKi	=	5.5	5.5	-194	45	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	15897	2860	3H-QNB	0	Human	Binding	pKi	=	5.5	5.5	-204	37	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2860	3H-QNB	0	Human	Binding	pKi	=	5.5	5.5	-204	37	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2860	3H-QNB	0	Human	Binding	pKi	=	5.5	5.5	-204	37	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	187	255	3H-NMS	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	3H-NMS	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	3H-NMS	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	3H-NMS	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	3H-NMS	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	3H-NMS	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	43815	186918	3H-QNB	64	Human	Binding	pKi	=	6.5	6.5	-15	25	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL1708	186918	3H-QNB	64	Human	Binding	pKi	=	6.5	6.5	-15	25	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL490	186918	3H-QNB	64	Human	Binding	pKi	=	6.5	6.5	-15	25	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	187	255	3H-MQNB(-)	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	3H-MQNB(-)	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	3H-MQNB(-)	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	3H-MQNB(-)	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	3H-MQNB(-)	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	3H-MQNB(-)	39	Human	Binding	pKi	=	6.5	6.5	6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	130169	3603	3H-NMS	0	Human	Binding	pKi	=	7.5	7.5	-26	5	NoneNone	PDSP KiDatabase	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	None
	331	3603	3H-NMS	0	Human	Binding	pKi	=	7.5	7.5	-26	5	NoneNone	PDSP KiDatabase	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	None
	242	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	242	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	242	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	470	3H-QNB	124	Human	Binding	pKi	=	5.5	5.5	-295	52	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	2389	3329	3H-QNB	118	Human	Binding	pKi	=	5.4	5.4	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3329	3H-QNB	118	Human	Binding	pKi	=	5.4	5.4	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3329	3H-QNB	118	Human	Binding	pKi	=	5.4	5.4	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3329	3H-QNB	118	Human	Binding	pKi	=	5.4	5.4	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3329	3H-QNB	118	Human	Binding	pKi	=	5.4	5.4	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2200	3129	3H-MQNB(-)	46	Human	Binding	pKi	=	6.4	6.4	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-MQNB(-)	46	Human	Binding	pKi	=	6.4	6.4	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-MQNB(-)	46	Human	Binding	pKi	=	6.4	6.4	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-MQNB(-)	46	Human	Binding	pKi	=	6.4	6.4	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-MQNB(-)	46	Human	Binding	pKi	=	6.4	6.4	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	3337	206365	3H-QNB	27	Human	Binding	pKi	=	5.4	5.4	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206365	3H-QNB	27	Human	Binding	pKi	=	5.4	5.4	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206365	3H-QNB	27	Human	Binding	pKi	=	5.4	5.4	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206365	3H-QNB	27	Human	Binding	pKi	=	5.4	5.4	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206365	3H-QNB	27	Human	Binding	pKi	=	5.4	5.4	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	DB00574	206365	3H-QNB	27	Human	Binding	pKi	=	5.4	5.4	-120	41	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	442108	84634	3H-QNB	6	Human	Binding	pKi	=	4.4	4.4	-3	12	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
	CHEMBL222287	84634	3H-QNB	6	Human	Binding	pKi	=	4.4	4.4	-3	12	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
	2370	622	None	31	Human	Binding	pKi	=	8.4	8.4	-1	5	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	297	622	None	31	Human	Binding	pKi	=	8.4	8.4	-1	5	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	358	622	None	31	Human	Binding	pKi	=	8.4	8.4	-1	5	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	CHEMBL1482	622	None	31	Human	Binding	pKi	=	8.4	8.4	-1	5	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	DB01019	622	None	31	Human	Binding	pKi	=	8.4	8.4	-1	5	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	5831	215961	3H-NMS	0	Human	Binding	pKi	=	8.4	8.4	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	3H-NMS	0	Human	Binding	pKi	=	8.4	8.4	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	3H-NMS	0	Human	Binding	pKi	=	8.4	8.4	-29	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	129989	451	3H-NMS	51	Human	Binding	pKi	=	8.4	8.4	-1	9	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
	8584	451	3H-NMS	51	Human	Binding	pKi	=	8.4	8.4	-1	9	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
	CHEMBL43383	451	3H-NMS	51	Human	Binding	pKi	=	8.4	8.4	-1	9	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
	10938	1700	None	0	Human	Binding	pKi	=	8.4	8.4	1	4	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
	299	1700	None	0	Human	Binding	pKi	=	8.4	8.4	1	4	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
	3256	1700	None	0	Human	Binding	pKi	=	8.4	8.4	1	4	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
	CHEMBL2110739	1700	None	0	Human	Binding	pKi	=	8.4	8.4	1	4	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
	154734599	2501	3H-NMS	12	Rat	Binding	pKi	=	8.3	8.3	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-NMS	12	Rat	Binding	pKi	=	8.3	8.3	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-NMS	12	Rat	Binding	pKi	=	8.3	8.3	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-NMS	12	Rat	Binding	pKi	=	8.3	8.3	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	154825138	216036	3H-NMS	0	Rat	Binding	pKi	=	8.3	8.3	-1	12	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	1734	116	3H-MQNB(-)	10	Human	Binding	pKi	=	8.3	8.3	-9	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	3H-MQNB(-)	10	Human	Binding	pKi	=	8.3	8.3	-9	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	3H-MQNB(-)	10	Human	Binding	pKi	=	8.3	8.3	-9	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	71128	96808	3H-NMS	25	Rat	Binding	pKi	=	8.3	8.3	-3	8	NoneNone	PDSP KiDatabase	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	None
	CHEMBL26505	96808	3H-NMS	25	Rat	Binding	pKi	=	8.3	8.3	-3	8	NoneNone	PDSP KiDatabase	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	None
	44431376	87315	UNDEFINED	0	Human	Binding	pKi	=	7.4	7.4	-2	3	NoneNone	PDSP KiDatabase	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	None
	CHEMBL233200	87315	UNDEFINED	0	Human	Binding	pKi	=	7.4	7.4	-2	3	NoneNone	PDSP KiDatabase	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	None
	135409468	2033	3H-QNB	69	Human	Binding	pKi	=	6.4	6.4	-114	40	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	333	2033	3H-QNB	69	Human	Binding	pKi	=	6.4	6.4	-114	40	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	CHEMBL845	2033	3H-QNB	69	Human	Binding	pKi	=	6.4	6.4	-114	40	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	2200	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	62865	1273	3H-Methoctramine	0	Human	Binding	pKi	=	7.4	7.4	-6	15	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	746	1273	3H-Methoctramine	0	Human	Binding	pKi	=	7.4	7.4	-6	15	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	84	1273	3H-Methoctramine	0	Human	Binding	pKi	=	7.4	7.4	-6	15	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	CHEMBL2104153	1273	3H-Methoctramine	0	Human	Binding	pKi	=	7.4	7.4	-6	15	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	DB09000	1273	3H-Methoctramine	0	Human	Binding	pKi	=	7.4	7.4	-6	15	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	154734599	2501	3H-MQNB(-)	12	Human	Binding	pKi	=	7.4	7.4	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-MQNB(-)	12	Human	Binding	pKi	=	7.4	7.4	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-MQNB(-)	12	Human	Binding	pKi	=	7.4	7.4	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-MQNB(-)	12	Human	Binding	pKi	=	7.4	7.4	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4919	206232	3H-NMS	23	Rat	Binding	pKi	=	7.4	7.4	-9	9	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	CHEMBL86715	206232	3H-NMS	23	Rat	Binding	pKi	=	7.4	7.4	-9	9	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	DB00387	206232	3H-NMS	23	Rat	Binding	pKi	=	7.4	7.4	-9	9	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	187	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.4	6.4	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.4	6.4	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.4	6.4	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.4	6.4	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.4	6.4	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.4	6.4	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	2726	918	3H-QNB	68	Human	Binding	pKi	=	6.4	6.4	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	918	3H-QNB	68	Human	Binding	pKi	=	6.4	6.4	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	918	3H-QNB	68	Human	Binding	pKi	=	6.4	6.4	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	918	3H-QNB	68	Human	Binding	pKi	=	6.4	6.4	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	918	3H-QNB	68	Human	Binding	pKi	=	6.4	6.4	-79	73	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	1979	77324	3H-cAMP	70	Rat	Binding	pKi	=	5.4	5.4	-14	4	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77324	3H-cAMP	70	Rat	Binding	pKi	=	5.4	5.4	-14	4	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	154734599	2501	3H-MQNB(-)	12	Rat	Binding	pKi	=	7.4	7.4	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-MQNB(-)	12	Rat	Binding	pKi	=	7.4	7.4	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-MQNB(-)	12	Rat	Binding	pKi	=	7.4	7.4	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-MQNB(-)	12	Rat	Binding	pKi	=	7.4	7.4	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	44431372	87313	UNDEFINED	0	Human	Binding	pKi	=	7.4	7.4	1	3	NoneNone	PDSP KiDatabase	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
	CHEMBL233198	87313	UNDEFINED	0	Human	Binding	pKi	=	7.4	7.4	1	3	NoneNone	PDSP KiDatabase	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
	2200	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.4	6.4	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	1830	2588	3H-QNB	44	Human	Binding	pKi	=	3.4	3.4	-79432	28	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2588	3H-QNB	44	Human	Binding	pKi	=	3.4	3.4	-79432	28	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2588	3H-QNB	44	Human	Binding	pKi	=	3.4	3.4	-79432	28	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2588	3H-QNB	44	Human	Binding	pKi	=	3.4	3.4	-79432	28	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2588	3H-QNB	44	Human	Binding	pKi	=	3.4	3.4	-79432	28	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	5831	215961	3H-MQNB(-)	0	Rat	Binding	pKi	=	5.4	5.4	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	3H-MQNB(-)	0	Rat	Binding	pKi	=	5.4	5.4	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	3H-MQNB(-)	0	Rat	Binding	pKi	=	5.4	5.4	-190	12	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	208	2861	3H-QNB	0	Human	Binding	pKi	=	5.3	5.3	-50	13	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	4541	2861	3H-QNB	0	Human	Binding	pKi	=	5.3	5.3	-50	13	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL1494	2861	3H-QNB	0	Human	Binding	pKi	=	5.3	5.3	-50	13	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	2200	3129	3H-NMS	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-NMS	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-NMS	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-NMS	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-NMS	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	72054	216226	3H-NMS	0	Human	Binding	pKi	=	7.3	7.3	-56	6	NoneNone	PDSP KiDatabase	426	7	1	3	4.0	C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5	None
	CHEMBL1346	216226	3H-NMS	0	Human	Binding	pKi	=	7.3	7.3	-56	6	NoneNone	PDSP KiDatabase	426	7	1	3	4.0	C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5	None
	DB00496	216226	3H-NMS	0	Human	Binding	pKi	=	7.3	7.3	-56	6	NoneNone	PDSP KiDatabase	426	7	1	3	4.0	C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5	None
	135398745	2912	3H-QNB	112	Human	Binding	pKi	=	7.3	7.3	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2912	3H-QNB	112	Human	Binding	pKi	=	7.3	7.3	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2912	3H-QNB	112	Human	Binding	pKi	=	7.3	7.3	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2912	3H-QNB	112	Human	Binding	pKi	=	7.3	7.3	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2200	3129	3H-NMS	46	Human	Binding	pKi	=	6.3	6.3	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-NMS	46	Human	Binding	pKi	=	6.3	6.3	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-NMS	46	Human	Binding	pKi	=	6.3	6.3	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-NMS	46	Human	Binding	pKi	=	6.3	6.3	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-NMS	46	Human	Binding	pKi	=	6.3	6.3	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	10090005	215984	3H-QNB	0	Human	Binding	pKi	=	6.3	6.3	-588	11	NoneNone	PDSP KiDatabase	361	1	0	3	4.4	CN1CCN(CC1)C2=CC3=C(C=CC(=C3)Cl)C(=CC#N)C4=CC=CC=C42	None
	135398737	957	3H-QNB	93	Human	Binding	pKi	=	7.3	7.3	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	957	3H-QNB	93	Human	Binding	pKi	=	7.3	7.3	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	957	3H-QNB	93	Human	Binding	pKi	=	7.3	7.3	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	957	3H-QNB	93	Human	Binding	pKi	=	7.3	7.3	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	957	3H-QNB	93	Human	Binding	pKi	=	7.3	7.3	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398745	2912	3H-QNB	112	Human	Binding	pKi	=	7.3	7.3	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2912	3H-QNB	112	Human	Binding	pKi	=	7.3	7.3	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2912	3H-QNB	112	Human	Binding	pKi	=	7.3	7.3	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2912	3H-QNB	112	Human	Binding	pKi	=	7.3	7.3	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	44431369	87981	UNDEFINED	0	Human	Binding	pKi	=	7.3	7.3	-2	3	NoneNone	PDSP KiDatabase	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
	CHEMBL234253	87981	UNDEFINED	0	Human	Binding	pKi	=	7.3	7.3	-2	3	NoneNone	PDSP KiDatabase	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
	302	2975	3H-MQNB(-)	25	Rat	Binding	pKi	=	6.3	6.3	-4	8	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	4630	2975	3H-MQNB(-)	25	Rat	Binding	pKi	=	6.3	6.3	-4	8	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	CHEMBL7634	2975	3H-MQNB(-)	25	Rat	Binding	pKi	=	6.3	6.3	-4	8	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	2745	3859	3H-NMS	42	Human	Binding	pKi	=	6.3	6.3	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	5572	3859	3H-NMS	42	Human	Binding	pKi	=	6.3	6.3	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	66007	3859	3H-NMS	42	Human	Binding	pKi	=	6.3	6.3	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	7315	3859	3H-NMS	42	Human	Binding	pKi	=	6.3	6.3	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	CHEMBL1490	3859	3H-NMS	42	Human	Binding	pKi	=	6.3	6.3	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	DB00376	3859	3H-NMS	42	Human	Binding	pKi	=	6.3	6.3	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	154734599	2501	3H-MQNB(-)	12	Rat	Binding	pKi	=	7.3	7.3	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-MQNB(-)	12	Rat	Binding	pKi	=	7.3	7.3	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-MQNB(-)	12	Rat	Binding	pKi	=	7.3	7.3	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-MQNB(-)	12	Rat	Binding	pKi	=	7.3	7.3	-1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	44431375	87314	UNDEFINED	0	Human	Binding	pKi	=	7.3	7.3	-2	3	NoneNone	PDSP KiDatabase	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	None
	CHEMBL233199	87314	UNDEFINED	0	Human	Binding	pKi	=	7.3	7.3	-2	3	NoneNone	PDSP KiDatabase	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	None
	44431370	87982	UNDEFINED	0	Human	Binding	pKi	=	7.3	7.3	-2	3	NoneNone	PDSP KiDatabase	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	None
	CHEMBL234254	87982	UNDEFINED	0	Human	Binding	pKi	=	7.3	7.3	-2	3	NoneNone	PDSP KiDatabase	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	None
	2166	3121	None	49	Rat	Binding	pKi	=	8.3	8.3	-4	8	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	305	3121	None	49	Rat	Binding	pKi	=	8.3	8.3	-4	8	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5910	3121	None	49	Rat	Binding	pKi	=	8.3	8.3	-4	8	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	CHEMBL550	3121	None	49	Rat	Binding	pKi	=	8.3	8.3	-4	8	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	DB01085	3121	None	49	Rat	Binding	pKi	=	8.3	8.3	-4	8	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	3823	50219	None	42	Human	Binding	pKi	=	8.3	8.3	-44	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	76973198	50219	None	42	Human	Binding	pKi	=	8.3	8.3	-44	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	CHEMBL157101	50219	None	42	Human	Binding	pKi	=	8.3	8.3	-44	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	44431391	146419	UNDEFINED	0	Human	Binding	pKi	=	8.3	8.3	-1	3	NoneNone	PDSP KiDatabase	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	None
	CHEMBL392186	146419	UNDEFINED	0	Human	Binding	pKi	=	8.3	8.3	-1	3	NoneNone	PDSP KiDatabase	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	None
	3389	217709	None	0	Human	Binding	pKi	=	8.3	8.3	1	26	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
	2812	4777	None	101	Human	Binding	pKi	=	8.3	8.3	-33	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	CHEMBL104	4777	None	101	Human	Binding	pKi	=	8.3	8.3	-33	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	2719	916	None	74	Human	Binding	pKi	=	8.3	8.3	-4	11	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
	5535	916	None	74	Human	Binding	pKi	=	8.3	8.3	-4	11	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
	607	916	None	74	Human	Binding	pKi	=	8.3	8.3	-4	11	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
	CHEMBL76	916	None	74	Human	Binding	pKi	=	8.3	8.3	-4	11	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
	DB00608	916	None	74	Human	Binding	pKi	=	8.3	8.3	-4	11	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
	441383	20331	None	57	Human	Binding	pKi	=	8.3	8.3	-7	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	CHEMBL1306	20331	None	57	Human	Binding	pKi	=	8.3	8.3	-7	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	2389	3329	None	118	Human	Binding	pKi	=	8.3	8.3	-2818	67	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3329	None	118	Human	Binding	pKi	=	8.3	8.3	-2818	67	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3329	None	118	Human	Binding	pKi	=	8.3	8.3	-2818	67	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3329	None	118	Human	Binding	pKi	=	8.3	8.3	-2818	67	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3329	None	118	Human	Binding	pKi	=	8.3	8.3	-2818	67	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	242	470	None	124	Human	Binding	pKi	=	8.3	8.3	-295	52	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	470	None	124	Human	Binding	pKi	=	8.3	8.3	-295	52	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	470	None	124	Human	Binding	pKi	=	8.3	8.3	-295	52	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	470	None	124	Human	Binding	pKi	=	8.3	8.3	-295	52	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	470	None	124	Human	Binding	pKi	=	8.3	8.3	-295	52	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	3294	2004	None	111	Human	Binding	pKi	=	8.3	8.3	-194	45	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	2004	None	111	Human	Binding	pKi	=	8.3	8.3	-194	45	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	2004	None	111	Human	Binding	pKi	=	8.3	8.3	-194	45	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	2004	None	111	Human	Binding	pKi	=	8.3	8.3	-194	45	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	2004	None	111	Human	Binding	pKi	=	8.3	8.3	-194	45	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	1016	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2561	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2733526	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	5384	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	CHEMBL83	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	DB00675	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-23	35	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	1209	1656	None	75	Human	Binding	pKi	=	8.3	8.3	-22	32	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1656	None	75	Human	Binding	pKi	=	8.3	8.3	-22	32	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1656	None	75	Human	Binding	pKi	=	8.3	8.3	-22	32	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1656	None	75	Human	Binding	pKi	=	8.3	8.3	-22	32	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1656	None	75	Human	Binding	pKi	=	8.3	8.3	-22	32	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	1212	1660	None	50	Human	Binding	pKi	=	8.3	8.3	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1660	None	50	Human	Binding	pKi	=	8.3	8.3	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1660	None	50	Human	Binding	pKi	=	8.3	8.3	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1660	None	50	Human	Binding	pKi	=	8.3	8.3	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1660	None	50	Human	Binding	pKi	=	8.3	8.3	-1380	66	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66265	94011	None	15	Human	Binding	pKi	=	8.3	8.3	-1	19	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL248702	94011	None	15	Human	Binding	pKi	=	8.3	8.3	-1	19	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	1210	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	1213	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	2725	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	33036	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	4411	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	616	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	6976	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	716121	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1201353	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1554789	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL505	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	DB01114	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	DB13679	917	None	51	Human	Binding	pKi	=	8.3	8.3	-257	21	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
	1273	1752	None	16	Rat	Binding	pKi	=	8.3	8.3	-1	3	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1752	None	16	Rat	Binding	pKi	=	8.3	8.3	-1	3	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1752	None	16	Rat	Binding	pKi	=	8.3	8.3	-1	3	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1752	None	16	Rat	Binding	pKi	=	8.3	8.3	-1	3	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1752	None	16	Rat	Binding	pKi	=	8.3	8.3	-1	3	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1752	None	16	Rat	Binding	pKi	=	8.3	8.3	-1	3	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1752	None	16	Rat	Binding	pKi	=	8.3	8.3	-1	3	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	15387	45820	None	55	Human	Binding	pKi	=	8.3	8.3	-16	24	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	CHEMBL1531134	45820	None	55	Human	Binding	pKi	=	8.3	8.3	-16	24	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	212	3804	None	47	Human	Binding	pKi	=	8.3	8.3	-5	25	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	2639	3804	None	47	Human	Binding	pKi	=	8.3	8.3	-5	25	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	941651	3804	None	47	Human	Binding	pKi	=	8.3	8.3	-5	25	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	CHEMBL1201	3804	None	47	Human	Binding	pKi	=	8.3	8.3	-5	25	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	DB01623	3804	None	47	Human	Binding	pKi	=	8.3	8.3	-5	25	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	68617	205525	None	62	Human	Binding	pKi	=	8.3	8.3	-32	26	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL1709	205525	None	62	Human	Binding	pKi	=	8.3	8.3	-32	26	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL809	205525	None	62	Human	Binding	pKi	=	8.3	8.3	-32	26	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	176	398	None	66	Human	Binding	pKi	=	8.2	8.2	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2157	398	None	66	Human	Binding	pKi	=	8.2	8.2	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2566	398	None	66	Human	Binding	pKi	=	8.2	8.2	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	CHEMBL633	398	None	66	Human	Binding	pKi	=	8.2	8.2	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	DB01118	398	None	66	Human	Binding	pKi	=	8.2	8.2	-2	31	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2448	99321	None	70	Human	Binding	pKi	=	8.2	8.2	-72	18	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	CHEMBL28218	99321	None	70	Human	Binding	pKi	=	8.2	8.2	-72	18	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	DB12401	99321	None	70	Human	Binding	pKi	=	8.2	8.2	-72	18	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	4189	206920	None	96	Human	Binding	pKi	=	8.2	8.2	-18	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL1559	206920	None	96	Human	Binding	pKi	=	8.2	8.2	-18	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL91	206920	None	96	Human	Binding	pKi	=	8.2	8.2	-18	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	1548955	88579	None	20	Human	Binding	pKi	=	8.2	8.2	-1	18	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	2800	88579	None	20	Human	Binding	pKi	=	8.2	8.2	-1	18	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	CHEMBL2355051	88579	None	20	Human	Binding	pKi	=	8.2	8.2	-1	18	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	3198	205511	None	76	Human	Binding	pKi	=	8.2	8.2	-16	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL1201049	205511	None	76	Human	Binding	pKi	=	8.2	8.2	-16	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL808	205511	None	76	Human	Binding	pKi	=	8.2	8.2	-16	34	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	2274	3171	None	58	Human	Binding	pKi	=	8.2	8.2	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3171	None	58	Human	Binding	pKi	=	8.2	8.2	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3171	None	58	Human	Binding	pKi	=	8.2	8.2	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3171	None	58	Human	Binding	pKi	=	8.2	8.2	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3171	None	58	Human	Binding	pKi	=	8.2	8.2	-100	32	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	3652	46242	None	70	Human	Binding	pKi	=	8.2	8.2	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
	CHEMBL1535	46242	None	70	Human	Binding	pKi	=	8.2	8.2	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
	72064	78399	None	14	Human	Binding	pKi	=	8.2	8.2	-2	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	Drug Central	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	None
	CHEMBL2110892	78399	None	14	Human	Binding	pKi	=	8.2	8.2	-2	3	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	Drug Central	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	None
	2774	3866	3H-NMS	95	Rat	Binding	pKi	=	7.3	7.3	-3	10	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	5593	3866	3H-NMS	95	Rat	Binding	pKi	=	7.3	7.3	-3	10	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	7319	3866	3H-NMS	95	Rat	Binding	pKi	=	7.3	7.3	-3	10	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	CHEMBL1200604	3866	3H-NMS	95	Rat	Binding	pKi	=	7.3	7.3	-3	10	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	DB00809	3866	3H-NMS	95	Rat	Binding	pKi	=	7.3	7.3	-3	10	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	DB01199	3866	3H-NMS	95	Rat	Binding	pKi	=	7.3	7.3	-3	10	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	310	1920	3H-QNB	0	Rat	Binding	pKi	=	7.3	7.3	-25	11	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	3602	1920	3H-QNB	0	Rat	Binding	pKi	=	7.3	7.3	-25	11	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	CHEMBL3545990	1920	3H-QNB	0	Rat	Binding	pKi	=	7.3	7.3	-25	11	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	2200	3129	3H-PIRENZEPINE	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-PIRENZEPINE	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-PIRENZEPINE	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-PIRENZEPINE	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-PIRENZEPINE	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	183782	3396	3H-NMS	20	Rat	Binding	pKi	=	5.3	5.3	-1202	15	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
	237	3396	3H-NMS	20	Rat	Binding	pKi	=	5.3	5.3	-1202	15	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL85251	3396	3H-NMS	20	Rat	Binding	pKi	=	5.3	5.3	-1202	15	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
	2200	3129	3H-NMS	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-NMS	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-NMS	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-NMS	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-NMS	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	1613	2346	3H-QNB	53	Human	Binding	pKi	=	6.3	6.3	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2346	3H-QNB	53	Human	Binding	pKi	=	6.3	6.3	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2346	3H-QNB	53	Human	Binding	pKi	=	6.3	6.3	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2346	3H-QNB	53	Human	Binding	pKi	=	6.3	6.3	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2346	3H-QNB	53	Human	Binding	pKi	=	6.3	6.3	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	1353	1909	3H-QNB	93	Human	Binding	pKi	=	5.3	5.3	-5011	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1909	3H-QNB	93	Human	Binding	pKi	=	5.3	5.3	-5011	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1909	3H-QNB	93	Human	Binding	pKi	=	5.3	5.3	-5011	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1909	3H-QNB	93	Human	Binding	pKi	=	5.3	5.3	-5011	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1909	3H-QNB	93	Human	Binding	pKi	=	5.3	5.3	-5011	86	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	2230	465	3H-MQNB(-)	60	Rat	Binding	pKi	=	5.3	5.3	-107	10	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	296	465	3H-MQNB(-)	60	Rat	Binding	pKi	=	5.3	5.3	-107	10	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	CHEMBL7303	465	3H-MQNB(-)	60	Rat	Binding	pKi	=	5.3	5.3	-107	10	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	DB04365	465	3H-MQNB(-)	60	Rat	Binding	pKi	=	5.3	5.3	-107	10	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	2200	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-MQNB(-)	46	Rat	Binding	pKi	=	6.3	6.3	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	2995	204403	3H-QNB	53	Human	Binding	pKi	=	6.3	6.3	-8	23	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204403	3H-QNB	53	Human	Binding	pKi	=	6.3	6.3	-8	23	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204403	3H-QNB	53	Human	Binding	pKi	=	6.3	6.3	-8	23	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	DB01151	204403	3H-QNB	53	Human	Binding	pKi	=	6.3	6.3	-8	23	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	15897	2860	3H-QNB	0	Human	Binding	pKi	=	5.3	5.3	-204	37	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2860	3H-QNB	0	Human	Binding	pKi	=	5.3	5.3	-204	37	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2860	3H-QNB	0	Human	Binding	pKi	=	5.3	5.3	-204	37	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	108107	79942	3H-NMS	38	Rat	Binding	pKi	=	5.2	5.2	-8	16	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	156592250	79942	3H-NMS	38	Rat	Binding	pKi	=	5.2	5.2	-8	16	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	CHEMBL1256878	79942	3H-NMS	38	Rat	Binding	pKi	=	5.2	5.2	-8	16	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	CHEMBL212579	79942	3H-NMS	38	Rat	Binding	pKi	=	5.2	5.2	-8	16	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	1613	2346	3H-QNB	53	Human	Binding	pKi	=	6.2	6.2	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2346	3H-QNB	53	Human	Binding	pKi	=	6.2	6.2	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2346	3H-QNB	53	Human	Binding	pKi	=	6.2	6.2	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2346	3H-QNB	53	Human	Binding	pKi	=	6.2	6.2	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2346	3H-QNB	53	Human	Binding	pKi	=	6.2	6.2	-42	45	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	9905731	168506	UNDEFINED	0	Human	Binding	pKi	=	8.2	8.2	1	3	NoneNone	PDSP KiDatabase	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	None
	CHEMBL435353	168506	UNDEFINED	0	Human	Binding	pKi	=	8.2	8.2	1	3	NoneNone	PDSP KiDatabase	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	None
	191	403	None	98	Human	Binding	pKi	=	8.2	8.2	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	403	None	98	Human	Binding	pKi	=	8.2	8.2	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	403	None	98	Human	Binding	pKi	=	8.2	8.2	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	403	None	98	Human	Binding	pKi	=	8.2	8.2	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	403	None	98	Human	Binding	pKi	=	8.2	8.2	-56	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	None	216256	3H-NMS	0	Human	Binding	pKi	=	8.2	8.2	1	5	NoneNone	PDSP KiDatabase	574	9	3	7	4.0	CCCN(CCC)CC1CCCCN1CCNC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4.CS(=O)(=O)O	None
	2337	3254	None	77	Human	Binding	pKi	=	8.2	8.2	-31	63	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3254	None	77	Human	Binding	pKi	=	8.2	8.2	-31	63	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3254	None	77	Human	Binding	pKi	=	8.2	8.2	-31	63	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3254	None	77	Human	Binding	pKi	=	8.2	8.2	-31	63	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3254	None	77	Human	Binding	pKi	=	8.2	8.2	-31	63	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	3236	67607	None	43	Human	Binding	pKi	=	8.2	8.2	1	2	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	None
	CHEMBL1902981	67607	None	43	Human	Binding	pKi	=	8.2	8.2	1	2	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	None
	1273	1752	None	16	Human	Binding	pKi	=	8.2	8.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1752	None	16	Human	Binding	pKi	=	8.2	8.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1752	None	16	Human	Binding	pKi	=	8.2	8.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1752	None	16	Human	Binding	pKi	=	8.2	8.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1752	None	16	Human	Binding	pKi	=	8.2	8.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1752	None	16	Human	Binding	pKi	=	8.2	8.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1752	None	16	Human	Binding	pKi	=	8.2	8.2	-1	3	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	4011	82406	None	49	Human	Binding	pKi	=	8.2	8.2	-35	24	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	CHEMBL21731	82406	None	49	Human	Binding	pKi	=	8.2	8.2	-35	24	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	44431382	88019	UNDEFINED	0	Human	Binding	pKi	=	8.2	8.2	-2	3	NoneNone	PDSP KiDatabase	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	None
	CHEMBL234438	88019	UNDEFINED	0	Human	Binding	pKi	=	8.2	8.2	-2	3	NoneNone	PDSP KiDatabase	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	None
	4098	32503	None	30	Human	Binding	pKi	=	8.2	8.2	-15	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	CHEMBL1255739	32503	None	30	Human	Binding	pKi	=	8.2	8.2	-15	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	CHEMBL1411979	32503	None	30	Human	Binding	pKi	=	8.2	8.2	-15	11	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	2995	204403	None	53	Human	Binding	pKi	=	8.2	8.2	-8	23	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204403	None	53	Human	Binding	pKi	=	8.2	8.2	-8	23	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204403	None	53	Human	Binding	pKi	=	8.2	8.2	-8	23	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	DB01151	204403	None	53	Human	Binding	pKi	=	8.2	8.2	-8	23	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	11057	176147	None	23	Human	Binding	pKi	=	8.2	8.2	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	3468	176147	None	23	Human	Binding	pKi	=	8.2	8.2	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	CHEMBL459265	176147	None	23	Human	Binding	pKi	=	8.2	8.2	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	CHEMBL64894	176147	None	23	Human	Binding	pKi	=	8.2	8.2	-1	20	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	4735	195113	None	96	Human	Binding	pKi	=	8.2	8.2	-9	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
	CHEMBL361506	195113	None	96	Human	Binding	pKi	=	8.2	8.2	-9	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
	CHEMBL55	195113	None	96	Human	Binding	pKi	=	8.2	8.2	-9	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
	2247	505	None	81	Human	Binding	pKi	=	8.2	8.2	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	249	505	None	81	Human	Binding	pKi	=	8.2	8.2	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	2603	505	None	81	Human	Binding	pKi	=	8.2	8.2	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	CHEMBL296419	505	None	81	Human	Binding	pKi	=	8.2	8.2	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	DB00637	505	None	81	Human	Binding	pKi	=	8.2	8.2	-32	42	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	2381	662	3H-QNB	48	Human	Binding	pKi	=	8.2	8.2	-15	9	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	374	662	3H-QNB	48	Human	Binding	pKi	=	8.2	8.2	-15	9	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	7128	662	3H-QNB	48	Human	Binding	pKi	=	8.2	8.2	-15	9	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	CHEMBL1101	662	3H-QNB	48	Human	Binding	pKi	=	8.2	8.2	-15	9	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	DB00810	662	3H-QNB	48	Human	Binding	pKi	=	8.2	8.2	-15	9	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	1530	2180	None	50	Human	Binding	pKi	=	8.2	8.2	-43	21	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	3827	2180	None	50	Human	Binding	pKi	=	8.2	8.2	-43	21	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	7206	2180	None	50	Human	Binding	pKi	=	8.2	8.2	-43	21	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	CHEMBL534	2180	None	50	Human	Binding	pKi	=	8.2	8.2	-43	21	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	DB00920	2180	None	50	Human	Binding	pKi	=	8.2	8.2	-43	21	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	6726	1279	None	51	Human	Binding	pKi	=	8.2	8.2	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	7151	1279	None	51	Human	Binding	pKi	=	8.2	8.2	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	749	1279	None	51	Human	Binding	pKi	=	8.2	8.2	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	CHEMBL648	1279	None	51	Human	Binding	pKi	=	8.2	8.2	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	DB01176	1279	None	51	Human	Binding	pKi	=	8.2	8.2	-9	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	1613	2346	None	53	Human	Binding	pKi	=	8.2	8.2	-42	45	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2346	None	53	Human	Binding	pKi	=	8.2	8.2	-42	45	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2346	None	53	Human	Binding	pKi	=	8.2	8.2	-42	45	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2346	None	53	Human	Binding	pKi	=	8.2	8.2	-42	45	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2346	None	53	Human	Binding	pKi	=	8.2	8.2	-42	45	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	6918558	14512	None	41	Human	Binding	pKi	=	8.2	8.2	-1	5	NoneNone	Drug Central	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	None
	CHEMBL1201764	14512	None	41	Human	Binding	pKi	=	8.2	8.2	-1	5	NoneNone	Drug Central	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	None
	DB06702	14512	None	41	Human	Binding	pKi	=	8.2	8.2	-1	5	NoneNone	Drug Central	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	None
	2284	3180	None	33	Human	Binding	pKi	=	8.2	8.2	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	4926	3180	None	33	Human	Binding	pKi	=	8.2	8.2	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	7281	3180	None	33	Human	Binding	pKi	=	8.2	8.2	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	CHEMBL564	3180	None	33	Human	Binding	pKi	=	8.2	8.2	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	DB00420	3180	None	33	Human	Binding	pKi	=	8.2	8.2	-21	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	135	2530	None	43	Human	Binding	pKi	=	8.2	8.2	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2530	None	43	Human	Binding	pKi	=	8.2	8.2	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2530	None	43	Human	Binding	pKi	=	8.2	8.2	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2530	None	43	Human	Binding	pKi	=	8.2	8.2	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2530	None	43	Human	Binding	pKi	=	8.2	8.2	-25	58	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	237	204863	None	48	Human	Binding	pKi	=	8.2	8.2	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
	CHEMBL546257	204863	None	48	Human	Binding	pKi	=	8.2	8.2	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
	CHEMBL554190	204863	None	48	Human	Binding	pKi	=	8.2	8.2	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
	CHEMBL7568	204863	None	48	Human	Binding	pKi	=	8.2	8.2	-1	13	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
	3947	206393	None	53	Human	Binding	pKi	=	8.2	8.2	-6	16	NoneNone	Drug Central	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
	CHEMBL87708	206393	None	53	Human	Binding	pKi	=	8.2	8.2	-6	16	NoneNone	Drug Central	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
	187	255	None	39	Human	Binding	pKi	=	8.2	8.2	6	9	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	None	39	Human	Binding	pKi	=	8.2	8.2	6	9	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	None	39	Human	Binding	pKi	=	8.2	8.2	6	9	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	None	39	Human	Binding	pKi	=	8.2	8.2	6	9	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	None	39	Human	Binding	pKi	=	8.2	8.2	6	9	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	None	39	Human	Binding	pKi	=	8.2	8.2	6	9	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	3191	102856	None	97	Human	Binding	pKi	=	8.2	8.2	-8	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
	CHEMBL305660	102856	None	97	Human	Binding	pKi	=	8.2	8.2	-8	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
	DB11742	102856	None	97	Human	Binding	pKi	=	8.2	8.2	-8	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
	3055	1432	None	44	Human	Binding	pKi	=	8.2	8.2	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
	313	1432	None	44	Human	Binding	pKi	=	8.2	8.2	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
	7163	1432	None	44	Human	Binding	pKi	=	8.2	8.2	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
	CHEMBL936	1432	None	44	Human	Binding	pKi	=	8.2	8.2	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
	DB01231	1432	None	44	Human	Binding	pKi	=	8.2	8.2	-2	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
	3042	1413	None	35	Human	Binding	pKi	=	8.2	8.2	-28	15	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	355	1413	None	35	Human	Binding	pKi	=	8.2	8.2	-28	15	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	868	1413	None	35	Human	Binding	pKi	=	8.2	8.2	-28	15	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	CHEMBL1123	1413	None	35	Human	Binding	pKi	=	8.2	8.2	-28	15	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	DB00804	1413	None	35	Human	Binding	pKi	=	8.2	8.2	-28	15	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	1353	1909	None	93	Rat	Binding	pKi	=	8.2	8.2	-338	86	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1909	None	93	Rat	Binding	pKi	=	8.2	8.2	-338	86	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1909	None	93	Rat	Binding	pKi	=	8.2	8.2	-338	86	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1909	None	93	Rat	Binding	pKi	=	8.2	8.2	-338	86	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1909	None	93	Rat	Binding	pKi	=	8.2	8.2	-338	86	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1935	3732	None	97	Mouse	Binding	pKi	=	8.2	8.2	-6	6	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	2551	3732	None	97	Mouse	Binding	pKi	=	8.2	8.2	-6	6	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	6687	3732	None	97	Mouse	Binding	pKi	=	8.2	8.2	-6	6	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	CHEMBL95	3732	None	97	Mouse	Binding	pKi	=	8.2	8.2	-6	6	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	DB00382	3732	None	97	Mouse	Binding	pKi	=	8.2	8.2	-6	6	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	2335	11846	None	22	Human	Binding	pKi	=	8.2	8.2	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
	8478	11846	None	22	Human	Binding	pKi	=	8.2	8.2	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
	CHEMBL1182210	11846	None	22	Human	Binding	pKi	=	8.2	8.2	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
	CHEMBL221753	11846	None	22	Human	Binding	pKi	=	8.2	8.2	-2	12	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
	6075	150106	None	42	Human	Binding	pKi	=	8.2	8.2	-7	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
	CHEMBL395110	150106	None	42	Human	Binding	pKi	=	8.2	8.2	-7	16	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
	26987	948	None	33	Human	Binding	pKi	=	8.2	8.2	-102	21	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	6063	948	None	33	Human	Binding	pKi	=	8.2	8.2	-102	21	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	671	948	None	33	Human	Binding	pKi	=	8.2	8.2	-102	21	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	CHEMBL1626	948	None	33	Human	Binding	pKi	=	8.2	8.2	-102	21	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	DB00283	948	None	33	Human	Binding	pKi	=	8.2	8.2	-102	21	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	1734	116	3H-MQNB(-)	10	Rat	Binding	pKi	=	8.2	8.2	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	3H-MQNB(-)	10	Rat	Binding	pKi	=	8.2	8.2	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	3H-MQNB(-)	10	Rat	Binding	pKi	=	8.2	8.2	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	43815	186918	None	64	Human	Binding	pKi	=	8.2	8.2	-15	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL1708	186918	None	64	Human	Binding	pKi	=	8.2	8.2	-15	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL490	186918	None	64	Human	Binding	pKi	=	8.2	8.2	-15	25	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	2726	918	None	68	Human	Binding	pKi	=	8.2	8.2	-79	73	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	918	None	68	Human	Binding	pKi	=	8.2	8.2	-79	73	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	918	None	68	Human	Binding	pKi	=	8.2	8.2	-79	73	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	918	None	68	Human	Binding	pKi	=	8.2	8.2	-79	73	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	918	None	68	Human	Binding	pKi	=	8.2	8.2	-79	73	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	2200	3129	None	46	Human	Binding	pKi	=	8.2	8.2	-35	13	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	None	46	Human	Binding	pKi	=	8.2	8.2	-35	13	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	None	46	Human	Binding	pKi	=	8.2	8.2	-35	13	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	8.2	8.2	-35	13	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	None	46	Human	Binding	pKi	=	8.2	8.2	-35	13	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	2562	204597	None	56	Human	Binding	pKi	=	8.2	8.2	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
	CHEMBL1256696	204597	None	56	Human	Binding	pKi	=	8.2	8.2	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
	CHEMBL73234	204597	None	56	Human	Binding	pKi	=	8.2	8.2	-1	2	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
	1225	1470	None	26	Human	Binding	pKi	=	8.2	8.2	-117	22	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	1470	None	26	Human	Binding	pKi	=	8.2	8.2	-117	22	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667468	1470	None	26	Human	Binding	pKi	=	8.2	8.2	-117	22	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	1470	None	26	Human	Binding	pKi	=	8.2	8.2	-117	22	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL101740	1470	None	26	Human	Binding	pKi	=	8.2	8.2	-117	22	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	1470	None	26	Human	Binding	pKi	=	8.2	8.2	-117	22	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	1470	None	26	Human	Binding	pKi	=	8.2	8.2	-117	22	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	103	4151	None	61	Human	Binding	pKi	=	8.2	8.2	-177	54	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4151	None	61	Human	Binding	pKi	=	8.2	8.2	-177	54	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4151	None	61	Human	Binding	pKi	=	8.2	8.2	-177	54	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4151	None	61	Human	Binding	pKi	=	8.2	8.2	-177	54	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4151	None	61	Human	Binding	pKi	=	8.2	8.2	-177	54	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	4601	206745	None	35	Human	Binding	pKi	=	8.2	8.2	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL1201023	206745	None	35	Human	Binding	pKi	=	8.2	8.2	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL900	206745	None	35	Human	Binding	pKi	=	8.2	8.2	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	DB01173	206745	None	35	Human	Binding	pKi	=	8.2	8.2	-2	17	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	4976	203577	None	29	Human	Binding	pKi	=	8.2	8.2	-1	12	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
	CHEMBL668	203577	None	29	Human	Binding	pKi	=	8.2	8.2	-1	12	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
	154059	3635	None	51	Rat	Binding	pKi	=	8.2	8.2	-3	8	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	2457	3635	None	51	Rat	Binding	pKi	=	8.2	8.2	-3	8	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	7483	3635	None	51	Rat	Binding	pKi	=	8.2	8.2	-3	8	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	CHEMBL1734	3635	None	51	Rat	Binding	pKi	=	8.2	8.2	-3	8	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	DB01591	3635	None	51	Rat	Binding	pKi	=	8.2	8.2	-3	8	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	3652	4095	None	79	Human	Binding	pKi	=	8.2	8.2	-18	18	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4095	None	79	Human	Binding	pKi	=	8.2	8.2	-18	18	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4095	None	79	Human	Binding	pKi	=	8.2	8.2	-18	18	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	8.2	8.2	-18	18	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4095	None	79	Human	Binding	pKi	=	8.2	8.2	-18	18	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	2200	3129	None	46	Rat	Binding	pKi	=	8.2	8.2	-31	13	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	None	46	Rat	Binding	pKi	=	8.2	8.2	-31	13	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	None	46	Rat	Binding	pKi	=	8.2	8.2	-31	13	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	=	8.2	8.2	-31	13	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	None	46	Rat	Binding	pKi	=	8.2	8.2	-31	13	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	1224	1431	None	83	Human	Binding	pKi	=	8.2	8.2	-6	13	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	3100	1431	None	83	Human	Binding	pKi	=	8.2	8.2	-6	13	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	8980	1431	None	83	Human	Binding	pKi	=	8.2	8.2	-6	13	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	916	1431	None	83	Human	Binding	pKi	=	8.2	8.2	-6	13	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	CHEMBL657	1431	None	83	Human	Binding	pKi	=	8.2	8.2	-6	13	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	DB01075	1431	None	83	Human	Binding	pKi	=	8.2	8.2	-6	13	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	1971	2864	None	38	Human	Binding	pKi	=	8.2	8.2	-9	30	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	2404	2864	None	38	Human	Binding	pKi	=	8.2	8.2	-9	30	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	4543	2864	None	38	Human	Binding	pKi	=	8.2	8.2	-9	30	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	CHEMBL445	2864	None	38	Human	Binding	pKi	=	8.2	8.2	-9	30	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	DB00540	2864	None	38	Human	Binding	pKi	=	8.2	8.2	-9	30	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	5284550	41719	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
	CHEMBL108947	41719	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
	CHEMBL1492500	41719	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
	DB09167	41719	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
	134688371	14427	None	10	Human	Binding	pKi	=	8.2	8.2	-	1	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
	13765	14427	None	10	Human	Binding	pKi	=	8.2	8.2	-	1	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
	CHEMBL1200623	14427	None	10	Human	Binding	pKi	=	8.2	8.2	-	1	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
	134	2512	3H-QNB	24	Human	Binding	pKi	=	5.2	5.2	-154	68	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2512	3H-QNB	24	Human	Binding	pKi	=	5.2	5.2	-154	68	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2512	3H-QNB	24	Human	Binding	pKi	=	5.2	5.2	-154	68	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2512	3H-QNB	24	Human	Binding	pKi	=	5.2	5.2	-154	68	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2512	3H-QNB	24	Human	Binding	pKi	=	5.2	5.2	-154	68	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1979	77324	3H-cAMP	70	Human	Binding	pKi	=	6.2	6.2	-2	4	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77324	3H-cAMP	70	Human	Binding	pKi	=	6.2	6.2	-2	4	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	2389	3329	3H-QNB	118	Human	Binding	pKi	=	5.2	5.2	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3329	3H-QNB	118	Human	Binding	pKi	=	5.2	5.2	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3329	3H-QNB	118	Human	Binding	pKi	=	5.2	5.2	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3329	3H-QNB	118	Human	Binding	pKi	=	5.2	5.2	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3329	3H-QNB	118	Human	Binding	pKi	=	5.2	5.2	-2818	67	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	6450478	216010	3H-QNB	0	Human	Binding	pKi	=	7.2	7.2	-1	12	NoneNone	PDSP KiDatabase	340	0	0	6	3.4	CN1CCN(CC1)C2=NC3=CSC=C3C(=CC#N)C4=CSC=C42	None
	135398745	2912	35S-GTPGammaS	112	Human	Binding	pKi	=	6.2	6.2	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2912	35S-GTPGammaS	112	Human	Binding	pKi	=	6.2	6.2	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2912	35S-GTPGammaS	112	Human	Binding	pKi	=	6.2	6.2	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2912	35S-GTPGammaS	112	Human	Binding	pKi	=	6.2	6.2	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2337	3254	3H-QNB	77	Human	Binding	pKi	=	6.2	6.2	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	2337	3254	3H-NMS	77	Rat	Binding	pKi	=	6.2	6.2	-70	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3254	3H-QNB	77	Human	Binding	pKi	=	6.2	6.2	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3254	3H-NMS	77	Rat	Binding	pKi	=	6.2	6.2	-70	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3254	3H-QNB	77	Human	Binding	pKi	=	6.2	6.2	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3254	3H-NMS	77	Rat	Binding	pKi	=	6.2	6.2	-70	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3254	3H-QNB	77	Human	Binding	pKi	=	6.2	6.2	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3254	3H-NMS	77	Rat	Binding	pKi	=	6.2	6.2	-70	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3254	3H-QNB	77	Human	Binding	pKi	=	6.2	6.2	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3254	3H-NMS	77	Rat	Binding	pKi	=	6.2	6.2	-70	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	2337	3254	3H-QNB	77	Human	Binding	pKi	=	6.2	6.2	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3254	3H-QNB	77	Human	Binding	pKi	=	6.2	6.2	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3254	3H-QNB	77	Human	Binding	pKi	=	6.2	6.2	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3254	3H-QNB	77	Human	Binding	pKi	=	6.2	6.2	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3254	3H-QNB	77	Human	Binding	pKi	=	6.2	6.2	-31	63	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	1712	2490	3H-QNB	43	Human	Binding	pKi	=	7.2	7.2	-5	22	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	4078	2490	3H-QNB	43	Human	Binding	pKi	=	7.2	7.2	-5	22	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	7227	2490	3H-QNB	43	Human	Binding	pKi	=	7.2	7.2	-5	22	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	CHEMBL1088	2490	3H-QNB	43	Human	Binding	pKi	=	7.2	7.2	-5	22	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	DB00933	2490	3H-QNB	43	Human	Binding	pKi	=	7.2	7.2	-5	22	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	277	1300	3H-QNB	62	Human	Binding	pKi	=	8.2	8.2	-12	50	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1300	3H-QNB	62	Human	Binding	pKi	=	8.2	8.2	-12	50	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1300	3H-QNB	62	Human	Binding	pKi	=	8.2	8.2	-12	50	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1300	3H-QNB	62	Human	Binding	pKi	=	8.2	8.2	-12	50	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1300	3H-QNB	62	Human	Binding	pKi	=	8.2	8.2	-12	50	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2745	3859	3H-QNB	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	5572	3859	3H-QNB	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	66007	3859	3H-QNB	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	7315	3859	3H-QNB	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	CHEMBL1490	3859	3H-QNB	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	DB00376	3859	3H-QNB	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	129894468	216103	None	0	Human	Binding	pKi	=	8.2	8.2	-	1	NoneNone	Drug Central	609	2	2	7	6.7	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC	None
	2398	953	None	62	Human	Binding	pKi	=	8.2	8.2	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	2801	953	None	62	Human	Binding	pKi	=	8.2	8.2	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	701	953	None	62	Human	Binding	pKi	=	8.2	8.2	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	CHEMBL415	953	None	62	Human	Binding	pKi	=	8.2	8.2	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	DB01242	953	None	62	Human	Binding	pKi	=	8.2	8.2	-3	29	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	1734	116	3H-NMS	10	Rat	Binding	pKi	=	8.2	8.2	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	3H-NMS	10	Rat	Binding	pKi	=	8.2	8.2	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	3H-NMS	10	Rat	Binding	pKi	=	8.2	8.2	-12	13	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	2745	3859	3H-NMS	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	5572	3859	3H-NMS	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	66007	3859	3H-NMS	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	7315	3859	3H-NMS	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	CHEMBL1490	3859	3H-NMS	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	DB00376	3859	3H-NMS	42	Human	Binding	pKi	=	8.2	8.2	-46	9	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	135398745	2912	None	112	Human	Binding	pKi	=	8.2	8.2	-38	66	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2912	None	112	Human	Binding	pKi	=	8.2	8.2	-38	66	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2912	None	112	Human	Binding	pKi	=	8.2	8.2	-38	66	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2912	None	112	Human	Binding	pKi	=	8.2	8.2	-38	66	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	4212	198677	None	82	Human	Binding	pKi	=	8.2	8.2	1	4	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
	CHEMBL1417019	198677	None	82	Human	Binding	pKi	=	8.2	8.2	1	4	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
	CHEMBL58	198677	None	82	Human	Binding	pKi	=	8.2	8.2	1	4	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
	73707487	216372	None	0	Human	Binding	pKi	=	8.2	8.2	1	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	355	3	1	4	2.5	CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br	None
	319	1323	None	44	Rat	Binding	pKi	=	8.1	8.1	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	321	1323	None	44	Rat	Binding	pKi	=	8.1	8.1	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	444031	1323	None	44	Rat	Binding	pKi	=	8.1	8.1	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	784	1323	None	44	Rat	Binding	pKi	=	8.1	8.1	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	CHEMBL1346	1323	None	44	Rat	Binding	pKi	=	8.1	8.1	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	DB00496	1323	None	44	Rat	Binding	pKi	=	8.1	8.1	-18	9	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	44431387	87316	UNDEFINED	0	Human	Binding	pKi	=	8.1	8.1	-1	3	NoneNone	PDSP KiDatabase	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	None
	CHEMBL233201	87316	UNDEFINED	0	Human	Binding	pKi	=	8.1	8.1	-1	3	NoneNone	PDSP KiDatabase	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	None
	1726	2495	None	13	Rat	Binding	pKi	=	8.1	8.1	-3	5	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	1993	2495	None	13	Rat	Binding	pKi	=	8.1	8.1	-3	5	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	7438	2495	None	13	Rat	Binding	pKi	=	8.1	8.1	-3	5	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	CHEMBL978	2495	None	13	Rat	Binding	pKi	=	8.1	8.1	-3	5	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	DB06709	2495	None	13	Rat	Binding	pKi	=	8.1	8.1	-3	5	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	1726	2495	None	13	Human	Binding	pKi	=	8.1	8.1	-2	5	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	1993	2495	None	13	Human	Binding	pKi	=	8.1	8.1	-2	5	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	7438	2495	None	13	Human	Binding	pKi	=	8.1	8.1	-2	5	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	CHEMBL978	2495	None	13	Human	Binding	pKi	=	8.1	8.1	-2	5	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	DB06709	2495	None	13	Human	Binding	pKi	=	8.1	8.1	-2	5	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	135398737	957	None	93	Human	Binding	pKi	=	8.1	8.1	-22	91	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	957	None	93	Human	Binding	pKi	=	8.1	8.1	-22	91	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	957	None	93	Human	Binding	pKi	=	8.1	8.1	-22	91	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	957	None	93	Human	Binding	pKi	=	8.1	8.1	-22	91	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	957	None	93	Human	Binding	pKi	=	8.1	8.1	-22	91	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	3042	1413	None	35	Rat	Binding	pKi	=	8.1	8.1	-12	15	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	355	1413	None	35	Rat	Binding	pKi	=	8.1	8.1	-12	15	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	868	1413	None	35	Rat	Binding	pKi	=	8.1	8.1	-12	15	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	CHEMBL1123	1413	None	35	Rat	Binding	pKi	=	8.1	8.1	-12	15	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	DB00804	1413	None	35	Rat	Binding	pKi	=	8.1	8.1	-12	15	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	135398737	957	None	93	Rat	Binding	pKi	=	8.1	8.1	-6	91	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	957	None	93	Rat	Binding	pKi	=	8.1	8.1	-6	91	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	957	None	93	Rat	Binding	pKi	=	8.1	8.1	-6	91	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	957	None	93	Rat	Binding	pKi	=	8.1	8.1	-6	91	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	957	None	93	Rat	Binding	pKi	=	8.1	8.1	-6	91	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	21855	84244	None	42	Human	Binding	pKi	=	8.1	8.1	-7	6	NoneNone	Drug Central	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	None
	CHEMBL22108	84244	None	42	Human	Binding	pKi	=	8.1	8.1	-7	6	NoneNone	Drug Central	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	None
	DB08801	84244	None	42	Human	Binding	pKi	=	8.1	8.1	-7	6	NoneNone	Drug Central	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	None
	62865	1273	None	0	Human	Binding	pKi	=	8.1	8.1	-6	15	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	746	1273	None	0	Human	Binding	pKi	=	8.1	8.1	-6	15	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	84	1273	None	0	Human	Binding	pKi	=	8.1	8.1	-6	15	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	CHEMBL2104153	1273	None	0	Human	Binding	pKi	=	8.1	8.1	-6	15	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	DB09000	1273	None	0	Human	Binding	pKi	=	8.1	8.1	-6	15	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	2774	3866	None	95	Human	Binding	pKi	=	8.1	8.1	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	5593	3866	None	95	Human	Binding	pKi	=	8.1	8.1	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	7319	3866	None	95	Human	Binding	pKi	=	8.1	8.1	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	CHEMBL1200604	3866	None	95	Human	Binding	pKi	=	8.1	8.1	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	DB00809	3866	None	95	Human	Binding	pKi	=	8.1	8.1	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	DB01199	3866	None	95	Human	Binding	pKi	=	8.1	8.1	-1	10	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	6472	202745	None	35	Rat	Binding	pKi	=	8.1	8.1	-4	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	None
	CHEMBL61946	202745	None	35	Rat	Binding	pKi	=	8.1	8.1	-4	2	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	None
	24096961	216105	3H-MQNB(-)	0	Human	Binding	pKi	=	8.1	8.1	-	1	NoneNone	PDSP KiDatabase	422	4	3	6	2.5	COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.OS(=O)(=O)O	None
	319	1323	None	44	Human	Binding	pKi	=	8.1	8.1	-20	9	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	321	1323	None	44	Human	Binding	pKi	=	8.1	8.1	-20	9	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	444031	1323	None	44	Human	Binding	pKi	=	8.1	8.1	-20	9	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	784	1323	None	44	Human	Binding	pKi	=	8.1	8.1	-20	9	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	CHEMBL1346	1323	None	44	Human	Binding	pKi	=	8.1	8.1	-20	9	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	DB00496	1323	None	44	Human	Binding	pKi	=	8.1	8.1	-20	9	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	124087	1388	None	114	Human	Binding	pKi	=	8.1	8.1	-6	15	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	7157	1388	None	114	Human	Binding	pKi	=	8.1	8.1	-6	15	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	814	1388	None	114	Human	Binding	pKi	=	8.1	8.1	-6	15	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	CHEMBL1172	1388	None	114	Human	Binding	pKi	=	8.1	8.1	-6	15	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	DB00967	1388	None	114	Human	Binding	pKi	=	8.1	8.1	-6	15	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	1371	1921	None	11	Human	Binding	pKi	=	8.1	8.1	-4	5	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
	24199	1921	None	11	Human	Binding	pKi	=	8.1	8.1	-4	5	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
	323	1921	None	11	Human	Binding	pKi	=	8.1	8.1	-4	5	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
	CHEMBL1201325	1921	None	11	Human	Binding	pKi	=	8.1	8.1	-4	5	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
	DB06787	1921	None	11	Human	Binding	pKi	=	8.1	8.1	-4	5	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
	10921	13043	None	23	Human	Binding	pKi	=	8.1	8.1	-	1	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	2968	13043	None	23	Human	Binding	pKi	=	8.1	8.1	-	1	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	CHEMBL1190	13043	None	23	Human	Binding	pKi	=	8.1	8.1	-	1	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	4919	206232	None	23	Human	Binding	pKi	=	8.1	8.1	-3	9	NoneNone	Drug Central	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	CHEMBL86715	206232	None	23	Human	Binding	pKi	=	8.1	8.1	-3	9	NoneNone	Drug Central	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	DB00387	206232	None	23	Human	Binding	pKi	=	8.1	8.1	-3	9	NoneNone	Drug Central	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	5648	78409	None	9	Human	Binding	pKi	=	8.1	8.1	-2	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
	CHEMBL2107687	78409	None	9	Human	Binding	pKi	=	8.1	8.1	-2	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
	CHEMBL2111176	78409	None	9	Human	Binding	pKi	=	8.1	8.1	-2	5	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
	2270	3169	None	69	Human	Binding	pKi	=	8.1	8.1	-	1	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	4811	3169	None	69	Human	Binding	pKi	=	8.1	8.1	-	1	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	4913	3169	None	69	Human	Binding	pKi	=	8.1	8.1	-	1	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	CHEMBL640	3169	None	69	Human	Binding	pKi	=	8.1	8.1	-	1	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	DB01035	3169	None	69	Human	Binding	pKi	=	8.1	8.1	-	1	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	1712	2490	None	43	Human	Binding	pKi	=	8.1	8.1	-5	22	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	4078	2490	None	43	Human	Binding	pKi	=	8.1	8.1	-5	22	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	7227	2490	None	43	Human	Binding	pKi	=	8.1	8.1	-5	22	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	CHEMBL1088	2490	None	43	Human	Binding	pKi	=	8.1	8.1	-5	22	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	DB00933	2490	None	43	Human	Binding	pKi	=	8.1	8.1	-5	22	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	100	3803	None	58	Human	Binding	pKi	=	8.1	8.1	-19	55	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3803	None	58	Human	Binding	pKi	=	8.1	8.1	-19	55	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3803	None	58	Human	Binding	pKi	=	8.1	8.1	-19	55	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3803	None	58	Human	Binding	pKi	=	8.1	8.1	-19	55	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3803	None	58	Human	Binding	pKi	=	8.1	8.1	-19	55	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2286	3181	None	51	Human	Binding	pKi	=	8.1	8.1	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	4927	3181	None	51	Human	Binding	pKi	=	8.1	8.1	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	7282	3181	None	51	Human	Binding	pKi	=	8.1	8.1	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	CHEMBL643	3181	None	51	Human	Binding	pKi	=	8.1	8.1	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	DB01069	3181	None	51	Human	Binding	pKi	=	8.1	8.1	-3	30	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	154825138	216036	3H-PIRENZEPINE	0	Rat	Binding	pKi	=	8.1	8.1	-1	12	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	187	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.2	6.2	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.2	6.2	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.2	6.2	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.2	6.2	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.2	6.2	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	3H-MQNB(-)	39	Rat	Binding	pKi	=	6.2	6.2	-6	9	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	279	1659	3H-QNB	26	Human	Binding	pKi	=	7.2	7.2	-14	18	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	49381	1659	3H-QNB	26	Human	Binding	pKi	=	7.2	7.2	-14	18	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	CHEMBL63756	1659	3H-QNB	26	Human	Binding	pKi	=	7.2	7.2	-14	18	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	1212	1660	3H-QNB	50	Human	Binding	pKi	=	5.1	5.1	-1380	66	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1660	3H-QNB	50	Human	Binding	pKi	=	5.1	5.1	-1380	66	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1660	3H-QNB	50	Human	Binding	pKi	=	5.1	5.1	-1380	66	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1660	3H-QNB	50	Human	Binding	pKi	=	5.1	5.1	-1380	66	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1660	3H-QNB	50	Human	Binding	pKi	=	5.1	5.1	-1380	66	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	None	216254	3H-NMS	0	Human	Binding	pKi	=	7.1	7.1	-5	5	NoneNone	PDSP KiDatabase	311	3	1	2	3.9	C1CCC(CC1)C(C#CCN2CCCCC2)(C3=CC=CC=C3)O	None
	154734599	2501	3H-QNB	12	Human	Binding	pKi	=	7.1	7.1	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2501	3H-QNB	12	Human	Binding	pKi	=	7.1	7.1	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2501	3H-QNB	12	Human	Binding	pKi	=	7.1	7.1	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2501	3H-QNB	12	Human	Binding	pKi	=	7.1	7.1	1	12	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	135398745	2912	3H-QNB	112	Human	Binding	pKi	=	7.1	7.1	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2912	3H-QNB	112	Human	Binding	pKi	=	7.1	7.1	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2912	3H-QNB	112	Human	Binding	pKi	=	7.1	7.1	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2912	3H-QNB	112	Human	Binding	pKi	=	7.1	7.1	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	11976	919	3H-QNB	59	Human	Binding	pKi	=	7.1	7.1	-23	24	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	919	3H-QNB	59	Human	Binding	pKi	=	7.1	7.1	-23	24	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	919	3H-QNB	59	Human	Binding	pKi	=	7.1	7.1	-23	24	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	919	3H-QNB	59	Human	Binding	pKi	=	7.1	7.1	-23	24	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	2200	3129	3H-NMS	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-NMS	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-NMS	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-NMS	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-NMS	46	Rat	Binding	pKi	=	6.1	6.1	-31	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	277	1300	None	62	Human	Binding	pKi	=	8.1	8.1	-12	50	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1300	None	62	Human	Binding	pKi	=	8.1	8.1	-12	50	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1300	None	62	Human	Binding	pKi	=	8.1	8.1	-12	50	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1300	None	62	Human	Binding	pKi	=	8.1	8.1	-12	50	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1300	None	62	Human	Binding	pKi	=	8.1	8.1	-12	50	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	1427	2011	None	54	Human	Binding	pKi	=	8.1	8.1	1	27	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2011	None	54	Human	Binding	pKi	=	8.1	8.1	1	27	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2011	None	54	Human	Binding	pKi	=	8.1	8.1	1	27	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2011	None	54	Human	Binding	pKi	=	8.1	8.1	1	27	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2011	None	54	Human	Binding	pKi	=	8.1	8.1	1	27	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	2028	2977	None	80	Human	Binding	pKi	=	8.1	8.1	-8	11	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	359	2977	None	80	Human	Binding	pKi	=	8.1	8.1	-8	11	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	4634	2977	None	80	Human	Binding	pKi	=	8.1	8.1	-8	11	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	CHEMBL1231	2977	None	80	Human	Binding	pKi	=	8.1	8.1	-8	11	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	DB01062	2977	None	80	Human	Binding	pKi	=	8.1	8.1	-8	11	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	5831	215961	None	0	Mouse	Binding	pKi	=	8.1	8.1	-1	12	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	None	0	Mouse	Binding	pKi	=	8.1	8.1	-1	12	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	None	0	Mouse	Binding	pKi	=	8.1	8.1	-1	12	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	180	401	None	56	Human	Binding	pKi	=	8.1	8.1	-27	40	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	401	None	56	Human	Binding	pKi	=	8.1	8.1	-27	40	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	401	None	56	Human	Binding	pKi	=	8.1	8.1	-27	40	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	401	None	56	Human	Binding	pKi	=	8.1	8.1	-27	40	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	401	None	56	Human	Binding	pKi	=	8.1	8.1	-27	40	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2028	2977	UNDEFINED	80	Human	Binding	pKi	=	8.1	8.1	-8	11	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	359	2977	UNDEFINED	80	Human	Binding	pKi	=	8.1	8.1	-8	11	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	4634	2977	UNDEFINED	80	Human	Binding	pKi	=	8.1	8.1	-8	11	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	CHEMBL1231	2977	UNDEFINED	80	Human	Binding	pKi	=	8.1	8.1	-8	11	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	DB01062	2977	UNDEFINED	80	Human	Binding	pKi	=	8.1	8.1	-8	11	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	1086	1588	None	27	Rat	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
	3290	1588	None	27	Rat	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
	7181	1588	None	27	Rat	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
	CHEMBL1206	1588	None	27	Rat	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
	DB00392	1588	None	27	Rat	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
	4904	155519	None	48	Human	Binding	pKi	=	8.1	8.1	-1	5	NoneNone	Drug Central	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	None
	CHEMBL404215	155519	None	48	Human	Binding	pKi	=	8.1	8.1	-1	5	NoneNone	Drug Central	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	None
	2028	2977	None	80	Rat	Binding	pKi	=	8.1	8.1	-5	11	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	359	2977	None	80	Rat	Binding	pKi	=	8.1	8.1	-5	11	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	4634	2977	None	80	Rat	Binding	pKi	=	8.1	8.1	-5	11	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	CHEMBL1231	2977	None	80	Rat	Binding	pKi	=	8.1	8.1	-5	11	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	DB01062	2977	None	80	Rat	Binding	pKi	=	8.1	8.1	-5	11	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	2705	3840	None	64	Rat	Binding	pKi	=	8.1	8.1	-1	10	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	360	3840	None	64	Rat	Binding	pKi	=	8.1	8.1	-1	10	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	443879	3840	None	64	Rat	Binding	pKi	=	8.1	8.1	-1	10	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	CHEMBL1382	3840	None	64	Rat	Binding	pKi	=	8.1	8.1	-1	10	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	DB01036	3840	None	64	Rat	Binding	pKi	=	8.1	8.1	-1	10	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	5831	215961	None	0	Rat	Binding	pKi	=	8.1	8.1	-190	12	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	215961	None	0	Rat	Binding	pKi	=	8.1	8.1	-190	12	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	215961	None	0	Rat	Binding	pKi	=	8.1	8.1	-190	12	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	2705	3840	None	64	Human	Binding	pKi	=	8.1	8.1	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	360	3840	None	64	Human	Binding	pKi	=	8.1	8.1	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	443879	3840	None	64	Human	Binding	pKi	=	8.1	8.1	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	CHEMBL1382	3840	None	64	Human	Binding	pKi	=	8.1	8.1	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	DB01036	3840	None	64	Human	Binding	pKi	=	8.1	8.1	-1	10	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	1201549	596	None	24	Rat	Binding	pKi	=	8.1	8.1	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	333	596	None	24	Rat	Binding	pKi	=	8.1	8.1	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	7601	596	None	24	Rat	Binding	pKi	=	8.1	8.1	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL1201203	596	None	24	Rat	Binding	pKi	=	8.1	8.1	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL438151	596	None	24	Rat	Binding	pKi	=	8.1	8.1	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	DB00245	596	None	24	Rat	Binding	pKi	=	8.1	8.1	-3	20	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	24835791	216102	None	0	Rat	Binding	pKi	=	8.1	8.1	-1	2	NoneNone	Drug Central	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	44431386	149023	UNDEFINED	0	Human	Binding	pKi	=	8.1	8.1	1	3	NoneNone	PDSP KiDatabase	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	None
	CHEMBL394255	149023	UNDEFINED	0	Human	Binding	pKi	=	8.1	8.1	1	3	NoneNone	PDSP KiDatabase	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	None
	25897919	55650	None	14	Human	Binding	pKi	=	8.1	8.1	-1	8	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	657308	55650	None	14	Human	Binding	pKi	=	8.1	8.1	-1	8	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	657309	55650	None	14	Human	Binding	pKi	=	8.1	8.1	-1	8	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL1464005	55650	None	14	Human	Binding	pKi	=	8.1	8.1	-1	8	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL1621597	55650	None	14	Human	Binding	pKi	=	8.1	8.1	-1	8	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	DB00332	55650	None	14	Human	Binding	pKi	=	8.1	8.1	-1	8	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	1201549	596	None	24	Human	Binding	pKi	=	8.1	8.1	-5	20	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	333	596	None	24	Human	Binding	pKi	=	8.1	8.1	-5	20	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	7601	596	None	24	Human	Binding	pKi	=	8.1	8.1	-5	20	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL1201203	596	None	24	Human	Binding	pKi	=	8.1	8.1	-5	20	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL438151	596	None	24	Human	Binding	pKi	=	8.1	8.1	-5	20	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	DB00245	596	None	24	Human	Binding	pKi	=	8.1	8.1	-5	20	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	11968014	12756	None	5	Human	Binding	pKi	=	8.1	8.1	-4	9	NoneNone	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	119680147	12756	None	5	Human	Binding	pKi	=	8.1	8.1	-4	9	NoneNone	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	CHEMBL1187846	12756	None	5	Human	Binding	pKi	=	8.1	8.1	-4	9	NoneNone	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	DB00747	12756	None	5	Human	Binding	pKi	=	8.1	8.1	-4	9	NoneNone	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	24835791	216102	None	0	Human	Binding	pKi	=	8.1	8.1	1	2	NoneNone	Drug Central	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	123134663	217726	None	0	Dog	Binding	pKi	=	8.1	8.1	-1	3	radioligand ([3H]QNB) displacement assayradioligand ([3H]QNB) displacement assay	Drug Central	330	2	0	2	5.4	C[N@+]12CCCC[C@@H]1CCC(C2)=C(C1=CC=CS1)C1=CC=CS1	None
	12057539	208039	None	42	Human	Binding	pKi	=	8.1	8.1	-2	21	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	None	42	Human	Binding	pKi	=	8.1	8.1	-2	21	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	None	42	Human	Binding	pKi	=	8.1	8.1	-2	21	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	135398737	957	3H-QNB	93	Human	Binding	pKi	=	7.1	7.1	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	957	3H-QNB	93	Human	Binding	pKi	=	7.1	7.1	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	957	3H-QNB	93	Human	Binding	pKi	=	7.1	7.1	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	957	3H-QNB	93	Human	Binding	pKi	=	7.1	7.1	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	957	3H-QNB	93	Human	Binding	pKi	=	7.1	7.1	-22	91	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	100	3803	3H-QNB	58	Human	Binding	pKi	=	6.1	6.1	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3803	3H-QNB	58	Human	Binding	pKi	=	6.1	6.1	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3803	3H-QNB	58	Human	Binding	pKi	=	6.1	6.1	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3803	3H-QNB	58	Human	Binding	pKi	=	6.1	6.1	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3803	3H-QNB	58	Human	Binding	pKi	=	6.1	6.1	-19	55	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	1427	2011	3H-QNB	54	Human	Binding	pKi	=	7.1	7.1	1	27	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2011	3H-QNB	54	Human	Binding	pKi	=	7.1	7.1	1	27	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2011	3H-QNB	54	Human	Binding	pKi	=	7.1	7.1	1	27	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2011	3H-QNB	54	Human	Binding	pKi	=	7.1	7.1	1	27	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2011	3H-QNB	54	Human	Binding	pKi	=	7.1	7.1	1	27	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	25897919	55650	None	14	Rat	Binding	pKi	=	8.0	8.0	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	657308	55650	None	14	Rat	Binding	pKi	=	8.0	8.0	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	657309	55650	None	14	Rat	Binding	pKi	=	8.0	8.0	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL1464005	55650	None	14	Rat	Binding	pKi	=	8.0	8.0	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL1621597	55650	None	14	Rat	Binding	pKi	=	8.0	8.0	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	DB00332	55650	None	14	Rat	Binding	pKi	=	8.0	8.0	-4	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208039	None	42	Rat	Binding	pKi	=	8.0	8.0	-2	21	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	None	42	Rat	Binding	pKi	=	8.0	8.0	-2	21	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	None	42	Rat	Binding	pKi	=	8.0	8.0	-2	21	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	10470	2486	None	7	Human	Binding	pKi	=	8.0	8.0	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
	1689	2486	None	7	Human	Binding	pKi	=	8.0	8.0	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
	4057	2486	None	7	Human	Binding	pKi	=	8.0	8.0	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
	CHEMBL524004	2486	None	7	Human	Binding	pKi	=	8.0	8.0	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
	DB04843	2486	None	7	Human	Binding	pKi	=	8.0	8.0	-4	3	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
	11693	1825	None	16	Human	Binding	pKi	=	8.0	8.0	-2	5	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	3494	1825	None	16	Human	Binding	pKi	=	8.0	8.0	-2	5	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	4302	1825	None	16	Human	Binding	pKi	=	8.0	8.0	-2	5	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	7459	1825	None	16	Human	Binding	pKi	=	8.0	8.0	-2	5	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	9933193	1825	None	16	Human	Binding	pKi	=	8.0	8.0	-2	5	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	CHEMBL1201335	1825	None	16	Human	Binding	pKi	=	8.0	8.0	-2	5	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	DB00986	1825	None	16	Human	Binding	pKi	=	8.0	8.0	-2	5	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	154417	23179	None	60	Human	Binding	pKi	=	8.0	8.0	-1	5	NoneNone	Drug Central	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	None
	CHEMBL1331216	23179	None	60	Human	Binding	pKi	=	8.0	8.0	-1	5	NoneNone	Drug Central	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	None
	12057539	208039	None	42	Mouse	Binding	pKi	=	8.0	8.0	-17	21	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208039	None	42	Mouse	Binding	pKi	=	8.0	8.0	-17	21	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208039	None	42	Mouse	Binding	pKi	=	8.0	8.0	-17	21	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	2293	3184	None	27	Human	Binding	pKi	=	8.0	8.0	-2	4	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
	329	3184	None	27	Human	Binding	pKi	=	8.0	8.0	-2	4	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
	4934	3184	None	27	Human	Binding	pKi	=	8.0	8.0	-2	4	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
	CHEMBL1180725	3184	None	27	Human	Binding	pKi	=	8.0	8.0	-2	4	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
	DB00782	3184	None	27	Human	Binding	pKi	=	8.0	8.0	-2	4	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
	10129	3320	None	0	Human	Binding	pKi	=	8.0	8.0	-1	5	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
	11753673	3320	None	0	Human	Binding	pKi	=	8.0	8.0	-1	5	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
	5303	3320	None	0	Human	Binding	pKi	=	8.0	8.0	-1	5	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
	CHEMBL3833319	3320	None	0	Human	Binding	pKi	=	8.0	8.0	-1	5	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
	DB11855	3320	None	0	Human	Binding	pKi	=	8.0	8.0	-1	5	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
	23724781	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	316	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	317	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	71183	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL1354199	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL3140030	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL376897	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	DB00462	2833	None	19	Human	Binding	pKi	=	8.0	8.0	-6	9	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	367	3822	None	12	Rat	Binding	pKi	=	8.0	8.0	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	5487427	3822	None	12	Rat	Binding	pKi	=	8.0	8.0	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	8592	3822	None	12	Rat	Binding	pKi	=	8.0	8.0	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL1900528	3822	None	12	Rat	Binding	pKi	=	8.0	8.0	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL3305968	3822	None	12	Rat	Binding	pKi	=	8.0	8.0	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL4650755	3822	None	12	Rat	Binding	pKi	=	8.0	8.0	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	DB01409	3822	None	12	Rat	Binding	pKi	=	8.0	8.0	-19	8	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	11519069	3937	None	3	Human	Binding	pKi	=	8.0	8.0	-1	5	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	11519070	3937	None	3	Human	Binding	pKi	=	8.0	8.0	-1	5	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	4816	3937	None	3	Human	Binding	pKi	=	8.0	8.0	-1	5	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	7354	3937	None	3	Human	Binding	pKi	=	8.0	8.0	-1	5	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	CHEMBL1187833	3937	None	3	Human	Binding	pKi	=	8.0	8.0	-1	5	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	DB09076	3937	None	3	Human	Binding	pKi	=	8.0	8.0	-1	5	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	44431367	87980	UNDEFINED	0	Human	Binding	pKi	=	7.1	7.1	-4	3	NoneNone	PDSP KiDatabase	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	None
	CHEMBL234252	87980	UNDEFINED	0	Human	Binding	pKi	=	7.1	7.1	-4	3	NoneNone	PDSP KiDatabase	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	None
	2200	3129	3H-NMS	46	Human	Binding	pKi	=	6.0	6.0	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3129	3H-NMS	46	Human	Binding	pKi	=	6.0	6.0	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3129	3H-NMS	46	Human	Binding	pKi	=	6.0	6.0	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3129	3H-NMS	46	Human	Binding	pKi	=	6.0	6.0	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3129	3H-NMS	46	Human	Binding	pKi	=	6.0	6.0	-35	13	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	24835791	216102	3H-MQNB(-)	0	Human	Binding	pKi	=	5.0	5.0	1	2	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	11954224	215951	3H-QNB	0	Human	Binding	pKi	=	6.0	6.0	-1047	60	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	3251	215951	3H-QNB	0	Human	Binding	pKi	=	6.0	6.0	-1047	60	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	CHEMBL1982133	215951	3H-QNB	0	Human	Binding	pKi	=	6.0	6.0	-1047	60	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	DB00696	215951	3H-QNB	0	Human	Binding	pKi	=	6.0	6.0	-1047	60	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	3036780	107529	3H-NMS	20	Human	Binding	pKi	=	6.0	6.0	-436	54	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	46780481	107529	3H-NMS	20	Human	Binding	pKi	=	6.0	6.0	-436	54	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107529	3H-NMS	20	Human	Binding	pKi	=	6.0	6.0	-436	54	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107529	3H-NMS	20	Human	Binding	pKi	=	6.0	6.0	-436	54	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107529	3H-NMS	20	Human	Binding	pKi	=	6.0	6.0	-436	54	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL504548	107529	3H-NMS	20	Human	Binding	pKi	=	6.0	6.0	-436	54	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	DB06216	107529	3H-NMS	20	Human	Binding	pKi	=	6.0	6.0	-436	54	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	135398745	2912	3H-NMS	112	Human	Binding	pKi	=	7.0	7.0	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2912	3H-NMSP	112	Human	Binding	pKi	=	7.0	7.0	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2912	3H-NMS	112	Human	Binding	pKi	=	7.0	7.0	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2912	3H-NMSP	112	Human	Binding	pKi	=	7.0	7.0	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2912	3H-NMS	112	Human	Binding	pKi	=	7.0	7.0	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2912	3H-NMSP	112	Human	Binding	pKi	=	7.0	7.0	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2912	3H-NMS	112	Human	Binding	pKi	=	7.0	7.0	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2912	3H-NMSP	112	Human	Binding	pKi	=	7.0	7.0	-38	66	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	129894468	216103	3H-MQNB(-)	0	Human	Binding	pKi	=	7.0	7.0	-	1	NoneNone	PDSP KiDatabase	609	2	2	7	6.7	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC	None
	10104	3564	None	12	Human	Binding	pKi	=	7.5	7.5	2	6	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
	6604866	3564	None	12	Human	Binding	pKi	=	7.5	7.5	2	6	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
	CHEMBL1493369	3564	None	12	Human	Binding	pKi	=	7.5	7.5	2	6	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
	10129	3320	None	0	Human	Binding	pKi	=	9.5	9.5	-1	5	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
	11753673	3320	None	0	Human	Binding	pKi	=	9.5	9.5	-1	5	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
	5303	3320	None	0	Human	Binding	pKi	=	9.5	9.5	-1	5	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
	CHEMBL3833319	3320	None	0	Human	Binding	pKi	=	9.5	9.5	-1	5	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
	DB11855	3320	None	0	Human	Binding	pKi	=	9.5	9.5	-1	5	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
	1201549	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	333	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	7601	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	CHEMBL1201203	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	CHEMBL438151	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	DB00245	596	None	24	Rat	Binding	pKi	=	8.6	8.6	-3	20	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	1086	1588	None	27	Rat	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
	3290	1588	None	27	Rat	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
	7181	1588	None	27	Rat	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
	CHEMBL1206	1588	None	27	Rat	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
	DB00392	1588	None	27	Rat	Binding	pKi	=	8.1	8.1	-1	2	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
	123603	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
	2684	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
	584	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
	9658	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
	CHEMBL168815	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
	DB00185	882	None	29	Human	Binding	pKi	=	6.1	6.1	1	4	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
	367	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	367	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	367	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	367	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	5487427	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	5487427	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	5487427	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	5487427	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	8592	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	8592	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	8592	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	8592	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	CHEMBL1900528	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	CHEMBL3305968	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	CHEMBL4650755	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	DB01409	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	DB01409	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	DB01409	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	DB01409	3822	None	12	Human	Binding	pKi	=	10.3	10.3	-2	8	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	8598	1271	None	0	Human	Binding	pKi	=	10.4	10.4	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	1053	16	2	11	9.9	O=C(Cc1ccc2c(c1)C(C)(C)C1=C3C=C4C(OC3CCN21)CC[N+]1=C4C(C)(C)c2c1ccc(c2)S([O-])([O-])[O-])NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
	91827377	1271	None	0	Human	Binding	pKi	=	10.4	10.4	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	1053	16	2	11	9.9	O=C(Cc1ccc2c(c1)C(C)(C)C1=C3C=C4C(OC3CCN21)CC[N+]1=C4C(C)(C)c2c1ccc(c2)S([O-])([O-])[O-])NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
	2370	622	None	31	Human	Binding	pKi	=	4	4.0	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
	2370	622	None	31	Human	Binding	pKi	=	4	4.0	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
	297	622	None	31	Human	Binding	pKi	=	4	4.0	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
	297	622	None	31	Human	Binding	pKi	=	4	4.0	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
	358	622	None	31	Human	Binding	pKi	=	4	4.0	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
	358	622	None	31	Human	Binding	pKi	=	4	4.0	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
	CHEMBL1482	622	None	31	Human	Binding	pKi	=	4	4.0	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
	CHEMBL1482	622	None	31	Human	Binding	pKi	=	4	4.0	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
	DB01019	622	None	31	Human	Binding	pKi	=	4	4.0	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
	DB01019	622	None	31	Human	Binding	pKi	=	4	4.0	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
	2166	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
	2166	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
	305	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
	305	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
	5910	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
	5910	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
	CHEMBL550	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
	CHEMBL550	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
	DB01085	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
	DB01085	3121	None	49	Human	Binding	pKi	=	4.9	4.9	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
	2551	793	None	23	Human	Binding	pKi	=	5.0	5.0	-6	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
	2551	793	None	23	Human	Binding	pKi	=	5.0	5.0	-6	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
	298	793	None	23	Human	Binding	pKi	=	5.0	5.0	-6	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
	298	793	None	23	Human	Binding	pKi	=	5.0	5.0	-6	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
	488	793	None	23	Human	Binding	pKi	=	5.0	5.0	-6	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
	488	793	None	23	Human	Binding	pKi	=	5.0	5.0	-6	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
	CHEMBL965	793	None	23	Human	Binding	pKi	=	5.0	5.0	-6	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
	CHEMBL965	793	None	23	Human	Binding	pKi	=	5.0	5.0	-6	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
	DB00411	793	None	23	Human	Binding	pKi	=	5.0	5.0	-6	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
	DB00411	793	None	23	Human	Binding	pKi	=	5.0	5.0	-6	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
	2230	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
	2230	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
	2230	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
	296	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
	296	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
	296	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
	CHEMBL7303	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
	CHEMBL7303	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
	CHEMBL7303	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
	DB04365	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
	DB04365	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
	DB04365	465	None	60	Human	Binding	pKi	=	5.2	5.2	-75	10	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
	129786	1889	None	0	Rat	Binding	pKi	=	5.3	5.3	-141	4	UnclassifiedUnclassified	Guide to Pharmacology	379	2	3	5	0.8	NC(=N)N1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	8813552
	3276	1889	None	0	Rat	Binding	pKi	=	5.3	5.3	-141	4	UnclassifiedUnclassified	Guide to Pharmacology	379	2	3	5	0.8	NC(=N)N1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	8813552
	187	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	187	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	187	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	294	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	294	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	294	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	65	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	65	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	65	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	8593	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	8593	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	8593	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	CHEMBL667	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	CHEMBL667	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	CHEMBL667	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	DB03128	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	DB03128	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	DB03128	255	None	39	Human	Binding	pKi	=	5.4	5.4	6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	302	2975	None	25	Human	Binding	pKi	=	5.8	5.8	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
	302	2975	None	25	Human	Binding	pKi	=	5.8	5.8	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
	4630	2975	None	25	Human	Binding	pKi	=	5.8	5.8	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
	4630	2975	None	25	Human	Binding	pKi	=	5.8	5.8	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
	CHEMBL7634	2975	None	25	Human	Binding	pKi	=	5.8	5.8	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
	CHEMBL7634	2975	None	25	Human	Binding	pKi	=	5.8	5.8	-34	8	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
	24768606	4028	None	58	Human	Binding	pKi	=	6.2	6.2	-39	5	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
	3274	4028	None	58	Human	Binding	pKi	=	6.2	6.2	-39	5	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
	CHEMBL1628667	4028	None	58	Human	Binding	pKi	=	6.2	6.2	-39	5	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
	2200	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
	2200	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
	2200	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
	2200	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
	2200	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
	2200	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
	2200	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
	2200	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	328	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
	328	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
	328	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
	328	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
	328	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
	328	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
	328	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
	328	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	4848	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
	4848	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
	4848	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
	4848	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
	4848	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
	4848	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
	4848	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
	4848	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
	CHEMBL9967	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	DB00670	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
	DB00670	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
	DB00670	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
	DB00670	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
	DB00670	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
	DB00670	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
	DB00670	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
	DB00670	3129	None	46	Human	Binding	pKi	=	6.4	6.4	-35	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	1273	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	1273	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	1273	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	3450	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	3450	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	3450	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	356	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	356	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	356	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	6172	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	6172	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	6172	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	67425	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	67425	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	67425	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	CHEMBL360055	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	CHEMBL360055	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	CHEMBL360055	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	DB00483	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	DB00483	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	DB00483	1752	None	16	Human	Binding	pKi	=	6.7	6.7	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	107867	2972	None	55	Human	Binding	pKi	=	7.0	7.0	2	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
	107867	2972	None	55	Human	Binding	pKi	=	7.0	7.0	2	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	309	2972	None	55	Human	Binding	pKi	=	7.0	7.0	2	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
	309	2972	None	55	Human	Binding	pKi	=	7.0	7.0	2	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	CHEMBL17045	2972	None	55	Human	Binding	pKi	=	7.0	7.0	2	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
	CHEMBL17045	2972	None	55	Human	Binding	pKi	=	7.0	7.0	2	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	5282426	1465	None	0	Human	Binding	pKi	=	7.0	7.0	-27	6	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
	7549	1465	None	0	Human	Binding	pKi	=	7.0	7.0	-27	6	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
	CHEMBL108947	1465	None	0	Human	Binding	pKi	=	7.0	7.0	-27	6	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
	CHEMBL1492500	1465	None	0	Human	Binding	pKi	=	7.0	7.0	-27	6	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
	DB09167	1465	None	0	Human	Binding	pKi	=	7.0	7.0	-27	6	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
	154059	3635	None	51	Human	Binding	pKi	=	7	7.0	-12	8	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
	154059	3635	None	51	Human	Binding	pKi	=	7	7.0	-12	8	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
	2457	3635	None	51	Human	Binding	pKi	=	7	7.0	-12	8	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
	2457	3635	None	51	Human	Binding	pKi	=	7	7.0	-12	8	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
	7483	3635	None	51	Human	Binding	pKi	=	7	7.0	-12	8	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
	7483	3635	None	51	Human	Binding	pKi	=	7	7.0	-12	8	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
	CHEMBL1734	3635	None	51	Human	Binding	pKi	=	7	7.0	-12	8	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
	CHEMBL1734	3635	None	51	Human	Binding	pKi	=	7	7.0	-12	8	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
	DB01591	3635	None	51	Human	Binding	pKi	=	7	7.0	-12	8	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
	DB01591	3635	None	51	Human	Binding	pKi	=	7	7.0	-12	8	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
	3652	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
	3652	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
	3652	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	57	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
	57	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
	57	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	60809	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
	60809	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
	60809	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
	CHEMBL21536	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	DB15357	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
	DB15357	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
	DB15357	4095	None	79	Human	Binding	pKi	=	7.2	7.2	-18	18	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	2774	3866	None	95	Human	Binding	pKi	=	7.2	7.2	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	5593	3866	None	95	Human	Binding	pKi	=	7.2	7.2	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	7319	3866	None	95	Human	Binding	pKi	=	7.2	7.2	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	CHEMBL1200604	3866	None	95	Human	Binding	pKi	=	7.2	7.2	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	DB00809	3866	None	95	Human	Binding	pKi	=	7.2	7.2	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	DB01199	3866	None	95	Human	Binding	pKi	=	7.2	7.2	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	1726	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
	1726	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
	1993	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
	1993	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
	7438	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
	7438	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
	CHEMBL978	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
	CHEMBL978	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
	DB06709	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
	DB06709	2495	None	13	Rat	Binding	pKi	=	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
	319	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	319	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	319	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	321	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	321	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	321	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	444031	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	444031	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	444031	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	784	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	784	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	784	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	CHEMBL1346	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	CHEMBL1346	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	CHEMBL1346	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	DB00496	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	DB00496	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	DB00496	1323	None	44	Human	Binding	pKi	=	7.3	7.3	-20	9	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	129140	3932	None	0	Human	Binding	pKi	=	7.4	7.4	-10	4	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	2043926
	129140	3932	None	0	Human	Binding	pKi	=	7.4	7.4	-10	4	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	9671109
	8583	3932	None	0	Human	Binding	pKi	=	7.4	7.4	-10	4	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	2043926
	8583	3932	None	0	Human	Binding	pKi	=	7.4	7.4	-10	4	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	9671109
	154734599	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
	154734599	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
	154734599	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
	154734599	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
	154734599	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
	154734599	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	327	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
	327	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
	327	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
	327	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
	327	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
	327	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	4108	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
	4108	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
	4108	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
	4108	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
	4108	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
	4108	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
	CHEMBL27673	2501	None	12	Human	Binding	pKi	=	7.9	7.9	1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	180	401	None	56	Human	Binding	pKi	=	7.9	7.9	-27	40	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
	200	401	None	56	Human	Binding	pKi	=	7.9	7.9	-27	40	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
	2160	401	None	56	Human	Binding	pKi	=	7.9	7.9	-27	40	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
	CHEMBL629	401	None	56	Human	Binding	pKi	=	7.9	7.9	-27	40	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
	DB00321	401	None	56	Human	Binding	pKi	=	7.9	7.9	-27	40	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
	2028	2977	None	80	Human	Binding	pKi	=	7.9	7.9	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	359	2977	None	80	Human	Binding	pKi	=	7.9	7.9	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	4634	2977	None	80	Human	Binding	pKi	=	7.9	7.9	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	CHEMBL1231	2977	None	80	Human	Binding	pKi	=	7.9	7.9	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	DB01062	2977	None	80	Human	Binding	pKi	=	7.9	7.9	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	2028	2977	None	80	Human	Binding	pKi	=	8	8.0	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
	2028	2977	None	80	Human	Binding	pKi	=	8	8.0	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	359	2977	None	80	Human	Binding	pKi	=	8	8.0	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
	359	2977	None	80	Human	Binding	pKi	=	8	8.0	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	4634	2977	None	80	Human	Binding	pKi	=	8	8.0	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
	4634	2977	None	80	Human	Binding	pKi	=	8	8.0	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	CHEMBL1231	2977	None	80	Human	Binding	pKi	=	8	8.0	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
	CHEMBL1231	2977	None	80	Human	Binding	pKi	=	8	8.0	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	DB01062	2977	None	80	Human	Binding	pKi	=	8	8.0	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
	DB01062	2977	None	80	Human	Binding	pKi	=	8	8.0	-8	11	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	324	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
	324	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
	324	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
	324	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	6436265	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
	6436265	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
	6436265	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
	6436265	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	CHEMBL277642	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
	CHEMBL277642	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
	CHEMBL277642	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
	CHEMBL277642	1923	None	15	Human	Binding	pKi	=	8.2	8.2	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	119357	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
	119357	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
	3264	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
	3264	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
	368	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
	368	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
	CHEMBL279453	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
	CHEMBL279453	304	None	49	Human	Binding	pKi	=	8.2	8.2	1	6	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
	1734	116	None	10	Human	Binding	pKi	=	8.4	8.4	-9	13	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
	307	116	None	10	Human	Binding	pKi	=	8.4	8.4	-9	13	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
	CHEMBL168067	116	None	10	Human	Binding	pKi	=	8.4	8.4	-9	13	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
	129989	451	None	51	Human	Binding	pKi	=	8.4	8.4	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
	129989	451	None	51	Human	Binding	pKi	=	8.4	8.4	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
	8584	451	None	51	Human	Binding	pKi	=	8.4	8.4	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
	8584	451	None	51	Human	Binding	pKi	=	8.4	8.4	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
	CHEMBL43383	451	None	51	Human	Binding	pKi	=	8.4	8.4	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
	CHEMBL43383	451	None	51	Human	Binding	pKi	=	8.4	8.4	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
	2705	3840	None	64	Human	Binding	pKi	=	8.5	8.5	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
	2705	3840	None	64	Human	Binding	pKi	=	8.5	8.5	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
	360	3840	None	64	Human	Binding	pKi	=	8.5	8.5	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
	360	3840	None	64	Human	Binding	pKi	=	8.5	8.5	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
	443879	3840	None	64	Human	Binding	pKi	=	8.5	8.5	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
	443879	3840	None	64	Human	Binding	pKi	=	8.5	8.5	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
	CHEMBL1382	3840	None	64	Human	Binding	pKi	=	8.5	8.5	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
	CHEMBL1382	3840	None	64	Human	Binding	pKi	=	8.5	8.5	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
	DB01036	3840	None	64	Human	Binding	pKi	=	8.5	8.5	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
	DB01036	3840	None	64	Human	Binding	pKi	=	8.5	8.5	-1	10	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
	174174	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
	174174	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
	174174	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
	174174	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
	260	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
	260	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
	260	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
	260	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
	320	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
	320	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
	320	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
	320	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
	CHEMBL517712	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
	DB00572	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
	DB00572	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
	DB00572	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
	DB00572	523	None	49	Human	Binding	pKi	=	8.5	8.5	-7	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
	8586	301	None	0	Human	Binding	pKi	=	8.6	8.6	-19	4	UnclassifiedUnclassified	Guide to Pharmacology	336	5	2	3	1.8	CN(C(=O)C(c1ccccc1)(c1ccccc1)O)C[C@@H]1[C@H]2[C@@H]1CNC2	20590605
	9862598	301	None	0	Human	Binding	pKi	=	8.6	8.6	-19	4	UnclassifiedUnclassified	Guide to Pharmacology	336	5	2	3	1.8	CN(C(=O)C(c1ccccc1)(c1ccccc1)O)C[C@@H]1[C@H]2[C@@H]1CNC2	20590605
	3000322	3560	None	38	Human	Binding	pKi	=	8.7	8.7	-5	6	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
	3000322	3560	None	38	Human	Binding	pKi	=	8.7	8.7	-5	6	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
	330	3560	None	38	Human	Binding	pKi	=	8.7	8.7	-5	6	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
	330	3560	None	38	Human	Binding	pKi	=	8.7	8.7	-5	6	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
	CHEMBL569713	3560	None	38	Human	Binding	pKi	=	8.7	8.7	-5	6	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
	CHEMBL569713	3560	None	38	Human	Binding	pKi	=	8.7	8.7	-5	6	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
	DB00747	3560	None	38	Human	Binding	pKi	=	8.7	8.7	-5	6	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
	DB00747	3560	None	38	Human	Binding	pKi	=	8.7	8.7	-5	6	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
	8600	342	None	0	Human	Binding	pKi	=	8.8	8.8	-3	2	UnclassifiedUnclassified	Guide to Pharmacology	1025	18	4	16	4.7	O=C(c1ccc(c(c1)C(=O)[O-])c1c2ccc(c(c2oc2c1ccc(=[NH2+])c2S([O-])([O-])[O-])S([O-])([O-])[O-])N)NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
	91827379	342	None	0	Human	Binding	pKi	=	8.8	8.8	-3	2	UnclassifiedUnclassified	Guide to Pharmacology	1025	18	4	16	4.7	O=C(c1ccc(c(c1)C(=O)[O-])c1c2ccc(c(c2oc2c1ccc(=[NH2+])c2S([O-])([O-])[O-])S([O-])([O-])[O-])N)NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
	30843	1401	None	0	Human	Binding	pKi	=	8.9	8.9	1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	354	1401	None	0	Human	Binding	pKi	=	8.9	8.9	1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	831	1401	None	0	Human	Binding	pKi	=	8.9	8.9	1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	CHEMBL1908364	1401	None	0	Human	Binding	pKi	=	8.9	8.9	1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	DB08997	1401	None	0	Human	Binding	pKi	=	8.9	8.9	1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	10470	2486	None	7	Human	Binding	pKi	=	9.2	9.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
	1689	2486	None	7	Human	Binding	pKi	=	9.2	9.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
	4057	2486	None	7	Human	Binding	pKi	=	9.2	9.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
	CHEMBL524004	2486	None	7	Human	Binding	pKi	=	9.2	9.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
	DB04843	2486	None	7	Human	Binding	pKi	=	9.2	9.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
	2293	3184	None	27	Human	Binding	pKi	=	9.5	9.5	-2	4	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
	329	3184	None	27	Human	Binding	pKi	=	9.5	9.5	-2	4	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
	4934	3184	None	27	Human	Binding	pKi	=	9.5	9.5	-2	4	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
	CHEMBL1180725	3184	None	27	Human	Binding	pKi	=	9.5	9.5	-2	4	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
	DB00782	3184	None	27	Human	Binding	pKi	=	9.5	9.5	-2	4	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
	11354367	3814	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	668	19	1	6	7.1	CCCN(C1CCN(CC1)Cc1c(OC)cccc1OC)CCCCCCCN1CC[C@H](C1)C(c1ccccc1)(c1ccccc1)C(=O)N	17478612
	3255	3814	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	668	19	1	6	7.1	CCCN(C1CCN(CC1)Cc1c(OC)cccc1OC)CCCCCCCN1CC[C@H](C1)C(c1ccccc1)(c1ccccc1)C(=O)N	17478612
	325	2060	None	0	Human	Binding	pKi	=	9.6	9.6	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
	325	2060	None	0	Human	Binding	pKi	=	9.6	9.6	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
	3746	2060	None	0	Human	Binding	pKi	=	9.6	9.6	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
	3746	2060	None	0	Human	Binding	pKi	=	9.6	9.6	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
	657308	2060	None	0	Human	Binding	pKi	=	9.6	9.6	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
	657308	2060	None	0	Human	Binding	pKi	=	9.6	9.6	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
	CHEMBL1615433	2060	None	0	Human	Binding	pKi	=	9.6	9.6	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
	CHEMBL1615433	2060	None	0	Human	Binding	pKi	=	9.6	9.6	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
	DB00332	2060	None	0	Human	Binding	pKi	=	9.6	9.6	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
	DB00332	2060	None	0	Human	Binding	pKi	=	9.6	9.6	-3	9	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
	132947	3862	None	9	Human	Binding	pKi	=	9.6	9.6	1	9	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
	361	3862	None	9	Human	Binding	pKi	=	9.6	9.6	1	9	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
	CHEMBL265256	3862	None	9	Human	Binding	pKi	=	9.6	9.6	1	9	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
	11519069	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	11519069	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	11519070	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	11519070	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	4816	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	4816	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	7354	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	7354	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	CHEMBL1187833	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	CHEMBL1187833	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	DB09076	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	DB09076	3937	None	3	Human	Binding	pKi	=	9.8	9.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	42519285	2575	None	15	Human	Binding	pKi	>	4.5	4.5	-60	5	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
	8591	2575	None	15	Human	Binding	pKi	>	4.5	4.5	-60	5	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
	CHEMBL3185781	2575	None	15	Human	Binding	pKi	>	4.5	4.5	-60	5	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
	314	2690	None	0	Human	Binding	pKi	>	5	5.0	-1122018	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10799315
	313	2689	None	0	Human	Binding	pKi	>	6	6.0	-407	6	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7925952
	134	2512	None	24	Human	Binding	pKi	None	8.3	8.3	-154	68	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2512	None	24	Human	Binding	pKi	None	8.3	8.3	-154	68	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2512	None	24	Human	Binding	pKi	None	8.3	8.3	-154	68	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2512	None	24	Human	Binding	pKi	None	8.3	8.3	-154	68	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2512	None	24	Human	Binding	pKi	None	8.3	8.3	-154	68	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	2865	4141	None	73	Human	Binding	pKi	None	8.3	8.3	-1659	54	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4141	None	73	Human	Binding	pKi	None	8.3	8.3	-1659	54	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4141	None	73	Human	Binding	pKi	None	8.3	8.3	-1659	54	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4141	None	73	Human	Binding	pKi	None	8.3	8.3	-1659	54	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4141	None	73	Human	Binding	pKi	None	8.3	8.3	-1659	54	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	3337	206365	None	27	Human	Binding	pKi	None	8.2	8.2	-120	41	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206365	None	27	Human	Binding	pKi	None	8.2	8.2	-120	41	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206365	None	27	Human	Binding	pKi	None	8.2	8.2	-120	41	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206365	None	27	Human	Binding	pKi	None	8.2	8.2	-120	41	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206365	None	27	Human	Binding	pKi	None	8.2	8.2	-120	41	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	DB00574	206365	None	27	Human	Binding	pKi	None	8.2	8.2	-120	41	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	3036780	107529	None	20	Human	Binding	pKi	None	8.2	8.2	-436	54	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	46780481	107529	None	20	Human	Binding	pKi	None	8.2	8.2	-436	54	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107529	None	20	Human	Binding	pKi	None	8.2	8.2	-436	54	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107529	None	20	Human	Binding	pKi	None	8.2	8.2	-436	54	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107529	None	20	Human	Binding	pKi	None	8.2	8.2	-436	54	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL504548	107529	None	20	Human	Binding	pKi	None	8.2	8.2	-436	54	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	DB06216	107529	None	20	Human	Binding	pKi	None	8.2	8.2	-436	54	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	11954224	215951	None	0	Human	Binding	pKi	None	8.2	8.2	-1047	60	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	3251	215951	None	0	Human	Binding	pKi	None	8.2	8.2	-1047	60	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	CHEMBL1982133	215951	None	0	Human	Binding	pKi	None	8.2	8.2	-1047	60	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	DB00696	215951	None	0	Human	Binding	pKi	None	8.2	8.2	-1047	60	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	3012003	216143	None	0	Human	Binding	pKi	None	8.2	8.2	-1	12	NoneNone	Drug Central	311	5	0	3	3.8	CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3	None
	2895	203590	None	41	Human	Binding	pKi	None	8.1	8.1	-1	8	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	CHEMBL669	203590	None	41	Human	Binding	pKi	None	8.1	8.1	-1	8	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	DB00924	203590	None	41	Human	Binding	pKi	None	8.1	8.1	-1	8	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	11976	919	None	59	Human	Binding	pKi	None	8.1	8.1	-23	24	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	919	None	59	Human	Binding	pKi	None	8.1	8.1	-23	24	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	919	None	59	Human	Binding	pKi	None	8.1	8.1	-23	24	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	919	None	59	Human	Binding	pKi	None	8.1	8.1	-23	24	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	4066	204624	None	78	Human	Binding	pKi	None	8.1	8.1	-1	7	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
	CHEMBL73451	204624	None	78	Human	Binding	pKi	None	8.1	8.1	-1	7	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
	DB01071	204624	None	78	Human	Binding	pKi	None	8.1	8.1	-1	7	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
	24096961	216105	None	0	Human	Binding	pKi	None	8.1	8.1	-	1	NoneNone	Drug Central	422	4	3	6	2.5	COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.OS(=O)(=O)O	None
	11757797	2840	None	0	Human	Binding	pKi	None	10.1	10.1	1	5	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccc(cc1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
	292	2840	None	0	Human	Binding	pKi	None	10.1	10.1	1	5	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccc(cc1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
	10938	1700	None	0	Human	Binding	pKi	None	4.5	4.5	1	4	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
	299	1700	None	0	Human	Binding	pKi	None	4.5	4.5	1	4	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
	3256	1700	None	0	Human	Binding	pKi	None	4.5	4.5	1	4	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
	CHEMBL2110739	1700	None	0	Human	Binding	pKi	None	4.5	4.5	1	4	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
	30844	2308	None	0	Rat	Binding	pKi	None	4.8	4.8	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	358	2308	None	0	Rat	Binding	pKi	None	4.8	4.8	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	300	2508	None	15	Human	Binding	pKi	None	4.9	4.9	1	6	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
	4141	2508	None	15	Human	Binding	pKi	None	4.9	4.9	1	6	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
	CHEMBL92387	2508	None	15	Human	Binding	pKi	None	4.9	4.9	1	6	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
	303	2976	None	17	Human	Binding	pKi	None	4.9	4.9	-1	6	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
	4629	2976	None	17	Human	Binding	pKi	None	4.9	4.9	-1	6	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
	8595	2976	None	17	Human	Binding	pKi	None	4.9	4.9	-1	6	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
	CHEMBL44674	2976	None	17	Human	Binding	pKi	None	4.9	4.9	-1	6	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
	30844	2308	None	0	Human	Binding	pKi	None	5	5.0	1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	358	2308	None	0	Human	Binding	pKi	None	5	5.0	1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	290	2471	None	6	Rat	Binding	pKi	None	5.4	5.4	-12	7	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
	4022	2471	None	6	Rat	Binding	pKi	None	5.4	5.4	-12	7	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
	5926	2471	None	6	Rat	Binding	pKi	None	5.4	5.4	-12	7	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
	CHEMBL40554	2471	None	6	Rat	Binding	pKi	None	5.4	5.4	-12	7	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
	CHEMBL74300	2471	None	6	Rat	Binding	pKi	None	5.4	5.4	-12	7	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
	22991950	2326	None	0	Human	Binding	pKi	None	5.4	5.4	-3	6	UnclassifiedUnclassified	Guide to Pharmacology	448	7	2	2	5.9	OC(C[N+](C)(C)C)CCCC(C1CCC2C1(C)CCC1C2CCC2C1(C)CCC(C2)O)C	12235229
	326	2326	None	0	Human	Binding	pKi	None	5.4	5.4	-3	6	UnclassifiedUnclassified	Guide to Pharmacology	448	7	2	2	5.9	OC(C[N+](C)(C)C)CCCC(C1CCC2C1(C)CCC1C2CCC2C1(C)CCC(C2)O)C	12235229
	1273	1752	None	16	Rat	Binding	pKi	None	5.6	5.6	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	3450	1752	None	16	Rat	Binding	pKi	None	5.6	5.6	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	356	1752	None	16	Rat	Binding	pKi	None	5.6	5.6	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	6172	1752	None	16	Rat	Binding	pKi	None	5.6	5.6	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	67425	1752	None	16	Rat	Binding	pKi	None	5.6	5.6	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	CHEMBL360055	1752	None	16	Rat	Binding	pKi	None	5.6	5.6	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	DB00483	1752	None	16	Rat	Binding	pKi	None	5.6	5.6	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	2229	464	None	22	Human	Binding	pKi	None	5.7	5.7	1	6	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
	295	464	None	22	Human	Binding	pKi	None	5.7	5.7	1	6	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
	CHEMBL128365	464	None	22	Human	Binding	pKi	None	5.7	5.7	1	6	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
	2551	793	None	23	Rat	Binding	pKi	None	5.7	5.7	-3	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
	298	793	None	23	Rat	Binding	pKi	None	5.7	5.7	-3	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
	488	793	None	23	Rat	Binding	pKi	None	5.7	5.7	-3	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
	CHEMBL965	793	None	23	Rat	Binding	pKi	None	5.7	5.7	-3	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
	DB00411	793	None	23	Rat	Binding	pKi	None	5.7	5.7	-3	11	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
	107867	2972	None	55	Rat	Binding	pKi	None	6.0	6.0	-14	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
	107867	2972	None	55	Rat	Binding	pKi	None	6.0	6.0	-14	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
	107867	2972	None	55	Rat	Binding	pKi	None	6.0	6.0	-14	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	309	2972	None	55	Rat	Binding	pKi	None	6.0	6.0	-14	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
	309	2972	None	55	Rat	Binding	pKi	None	6.0	6.0	-14	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
	309	2972	None	55	Rat	Binding	pKi	None	6.0	6.0	-14	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	CHEMBL17045	2972	None	55	Rat	Binding	pKi	None	6.0	6.0	-14	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
	CHEMBL17045	2972	None	55	Rat	Binding	pKi	None	6.0	6.0	-14	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
	CHEMBL17045	2972	None	55	Rat	Binding	pKi	None	6.0	6.0	-14	11	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	2200	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
	2200	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
	2200	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	328	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
	328	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
	328	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	4848	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
	4848	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
	4848	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
	CHEMBL9967	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	DB00670	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
	DB00670	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
	DB00670	3129	None	46	Rat	Binding	pKi	None	6.4	6.4	-31	13	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	308	2058	None	23	Human	Binding	pKi	None	6.4	6.4	-11	9	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
	308	2058	None	23	Human	Binding	pKi	None	6.4	6.4	-11	9	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
	3603	2058	None	23	Human	Binding	pKi	None	6.4	6.4	-11	9	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
	3603	2058	None	23	Human	Binding	pKi	None	6.4	6.4	-11	9	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
	CHEMBL1256682	2058	None	23	Human	Binding	pKi	None	6.4	6.4	-11	9	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
	CHEMBL1256682	2058	None	23	Human	Binding	pKi	None	6.4	6.4	-11	9	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
	187	255	None	39	Rat	Binding	pKi	None	6.4	6.4	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	294	255	None	39	Rat	Binding	pKi	None	6.4	6.4	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	65	255	None	39	Rat	Binding	pKi	None	6.4	6.4	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	8593	255	None	39	Rat	Binding	pKi	None	6.4	6.4	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	CHEMBL667	255	None	39	Rat	Binding	pKi	None	6.4	6.4	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	DB03128	255	None	39	Rat	Binding	pKi	None	6.4	6.4	-6	9	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	302	2975	None	25	Rat	Binding	pKi	None	6.5	6.5	-4	8	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
	4630	2975	None	25	Rat	Binding	pKi	None	6.5	6.5	-4	8	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
	CHEMBL7634	2975	None	25	Rat	Binding	pKi	None	6.5	6.5	-4	8	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
	3042	1413	None	35	Human	Binding	pKi	None	6.6	6.6	-28	15	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
	355	1413	None	35	Human	Binding	pKi	None	6.6	6.6	-28	15	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
	868	1413	None	35	Human	Binding	pKi	None	6.6	6.6	-28	15	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
	CHEMBL1123	1413	None	35	Human	Binding	pKi	None	6.6	6.6	-28	15	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
	DB00804	1413	None	35	Human	Binding	pKi	None	6.6	6.6	-28	15	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
	310	1920	None	0	Human	Binding	pKi	None	6.7	6.7	-56	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
	310	1920	None	0	Human	Binding	pKi	None	6.7	6.7	-56	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
	310	1920	None	0	Human	Binding	pKi	None	6.7	6.7	-56	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	3602	1920	None	0	Human	Binding	pKi	None	6.7	6.7	-56	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
	3602	1920	None	0	Human	Binding	pKi	None	6.7	6.7	-56	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
	3602	1920	None	0	Human	Binding	pKi	None	6.7	6.7	-56	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	CHEMBL3545990	1920	None	0	Human	Binding	pKi	None	6.7	6.7	-56	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
	CHEMBL3545990	1920	None	0	Human	Binding	pKi	None	6.7	6.7	-56	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
	CHEMBL3545990	1920	None	0	Human	Binding	pKi	None	6.7	6.7	-56	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	124226	1919	None	0	Human	Binding	pKi	None	6.7	6.7	-19	5	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
	322	1919	None	0	Human	Binding	pKi	None	6.7	6.7	-19	5	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
	310	1920	None	0	Rat	Binding	pKi	None	6.8	6.8	-25	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
	310	1920	None	0	Rat	Binding	pKi	None	6.8	6.8	-25	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	3602	1920	None	0	Rat	Binding	pKi	None	6.8	6.8	-25	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
	3602	1920	None	0	Rat	Binding	pKi	None	6.8	6.8	-25	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	CHEMBL3545990	1920	None	0	Rat	Binding	pKi	None	6.8	6.8	-25	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
	CHEMBL3545990	1920	None	0	Rat	Binding	pKi	None	6.8	6.8	-25	11	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	1427	2011	None	54	Human	Binding	pKi	None	6.9	6.9	1	27	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
	357	2011	None	54	Human	Binding	pKi	None	6.9	6.9	1	27	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
	3696	2011	None	54	Human	Binding	pKi	None	6.9	6.9	1	27	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
	CHEMBL11	2011	None	54	Human	Binding	pKi	None	6.9	6.9	1	27	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
	DB00458	2011	None	54	Human	Binding	pKi	None	6.9	6.9	1	27	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
	10259588	4077	None	0	Human	Binding	pKi	None	6.9	6.9	-	1	UnclassifiedUnclassified	Guide to Pharmacology	604	12	0	8	2.6	O=C1N(CO/N=C\c2cc[n+](cc2)CCC[n+]2ccc(cc2)/C=N\OCN2C(=O)c3c(C2=O)cccc3)C(=O)c2c1cccc2	12815174
	363	4077	None	0	Human	Binding	pKi	None	6.9	6.9	-	1	UnclassifiedUnclassified	Guide to Pharmacology	604	12	0	8	2.6	O=C1N(CO/N=C\c2cc[n+](cc2)CCC[n+]2ccc(cc2)/C=N\OCN2C(=O)c3c(C2=O)cccc3)C(=O)c2c1cccc2	12815174
	10426487	2839	None	7	Human	Binding	pKi	None	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
	291	2839	None	7	Human	Binding	pKi	None	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
	CHEMBL99521	2839	None	7	Human	Binding	pKi	None	7.2	7.2	-3	5	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
	154734599	2501	None	12	Rat	Binding	pKi	None	7.3	7.3	-1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	327	2501	None	12	Rat	Binding	pKi	None	7.3	7.3	-1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	4108	2501	None	12	Rat	Binding	pKi	None	7.3	7.3	-1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	CHEMBL27673	2501	None	12	Rat	Binding	pKi	None	7.3	7.3	-1	12	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	130169	3603	None	0	Human	Binding	pKi	None	7.5	7.5	-26	5	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	2704370
	331	3603	None	0	Human	Binding	pKi	None	7.5	7.5	-26	5	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	2704370
	1371	1921	None	11	Human	Binding	pKi	None	7.6	7.6	-4	5	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
	24199	1921	None	11	Human	Binding	pKi	None	7.6	7.6	-4	5	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
	323	1921	None	11	Human	Binding	pKi	None	7.6	7.6	-4	5	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
	CHEMBL1201325	1921	None	11	Human	Binding	pKi	None	7.6	7.6	-4	5	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
	DB06787	1921	None	11	Human	Binding	pKi	None	7.6	7.6	-4	5	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
	167962	4067	None	4	Human	Binding	pKi	None	7.6	7.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	362	4067	None	4	Human	Binding	pKi	None	7.6	7.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	CHEMBL31599	4067	None	4	Human	Binding	pKi	None	7.6	7.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	324	1923	None	15	Rat	Binding	pKi	None	7.9	7.9	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	6436265	1923	None	15	Rat	Binding	pKi	None	7.9	7.9	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	CHEMBL277642	1923	None	15	Rat	Binding	pKi	None	7.9	7.9	-1	9	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	10062394	3045	None	1	Human	Binding	pKi	None	7.9	7.9	-6	4	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
	304	3045	None	1	Human	Binding	pKi	None	7.9	7.9	-6	4	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
	CHEMBL130715	3045	None	1	Human	Binding	pKi	None	7.9	7.9	-6	4	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
	1734	116	None	10	Rat	Binding	pKi	None	8.2	8.2	-12	13	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
	1734	116	None	10	Rat	Binding	pKi	None	8.2	8.2	-12	13	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
	307	116	None	10	Rat	Binding	pKi	None	8.2	8.2	-12	13	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
	307	116	None	10	Rat	Binding	pKi	None	8.2	8.2	-12	13	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
	CHEMBL168067	116	None	10	Rat	Binding	pKi	None	8.2	8.2	-12	13	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
	CHEMBL168067	116	None	10	Rat	Binding	pKi	None	8.2	8.2	-12	13	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
	293	2841	None	0	Human	Binding	pKi	None	8.2	8.2	-2	5	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1cccc(c1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
	9985526	2841	None	0	Human	Binding	pKi	None	8.2	8.2	-2	5	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1cccc(c1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
	10350027	1427	None	0	Human	Binding	pKi	None	8.5	8.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	364	1427	None	0	Human	Binding	pKi	None	8.5	8.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	365	1427	None	0	Human	Binding	pKi	None	8.5	8.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	350	3554	None	7	Human	Binding	pKi	None	8.6	8.6	26	2	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
	9867750	3554	None	7	Human	Binding	pKi	None	8.6	8.6	26	2	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
	CHEMBL73341	3554	None	7	Human	Binding	pKi	None	8.6	8.6	26	2	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
	30843	1401	None	0	Rat	Binding	pKi	None	8.8	8.8	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	354	1401	None	0	Rat	Binding	pKi	None	8.8	8.8	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	831	1401	None	0	Rat	Binding	pKi	None	8.8	8.8	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	CHEMBL1908364	1401	None	0	Rat	Binding	pKi	None	8.8	8.8	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	DB08997	1401	None	0	Rat	Binding	pKi	None	8.8	8.8	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	174174	523	None	49	Rat	Binding	pKi	None	9.1	9.1	-4	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
	174174	523	None	49	Rat	Binding	pKi	None	9.1	9.1	-4	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
	260	523	None	49	Rat	Binding	pKi	None	9.1	9.1	-4	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
	260	523	None	49	Rat	Binding	pKi	None	9.1	9.1	-4	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
	320	523	None	49	Rat	Binding	pKi	None	9.1	9.1	-4	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
	320	523	None	49	Rat	Binding	pKi	None	9.1	9.1	-4	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
	CHEMBL517712	523	None	49	Rat	Binding	pKi	None	9.1	9.1	-4	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
	CHEMBL517712	523	None	49	Rat	Binding	pKi	None	9.1	9.1	-4	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
	DB00572	523	None	49	Rat	Binding	pKi	None	9.1	9.1	-4	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
	DB00572	523	None	49	Rat	Binding	pKi	None	9.1	9.1	-4	14	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790

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Ligand source activities (1 row/activity)