GPCRdb

dimethyltryptamine

Agent/drug
Bioactivity

dimethyltryptamine

SMILES	CN(C)CCc1c[nH]c2ccccc12
InChIKey	DMULVCHRPCFFGV-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	1
Hydrogen bond donors	1
Rotatable bonds	3
Molecular weight (Da)	188.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.32	6.44	6.55	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.43	6.50	6.58	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.80	5.81	5.82	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.82	5.89	5.96	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.12	6.13	6.14	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.38	5.47	5.57	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.59	6.59	6.59	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.39	6.78	7.00	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	6.09	6.92	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.61	6.61	6.61	PDSP Ki database
5-HT_1A	F6Q2H9	Bovine	5-Hydroxytryptamine	A	pKi	6.85	6.85	6.85	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.66	5.66	5.66	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.74	5.78	5.82	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	7.00	7.15	7.30	Guide to Pharmacology
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.57	6.80	7.03	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	6.46	6.78	7.15	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.34	6.34	6.34	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.19	7.27	7.40	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.63	6.56	7.28	PDSP Ki database

Showing 1 to 20 of 39 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	6.00	6.12	6.24	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pIC50	6.03	6.10	6.17	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	5.49	5.50	5.51	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.52	5.58	5.65	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.78	5.79	5.80	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.02	5.12	5.21	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	6.72	6.73	6.75	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pIC50	5.62	5.66	5.70	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	7.65	7.65	7.65	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.66	6.74	6.82	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.32	6.36	6.39	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.28	6.35	6.41	ChEMBL
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pIC50	5.48	5.48	5.48	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	5.92	5.95	5.97	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pIC50	6.92	6.98	7.05	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	6.28	6.38	6.47	ChEMBL

Showing 1 to 16 of 16 entries

dimethyltryptamine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb

Compound is not listed as a drug.