GPCRdb

arecoline

Agent/drug
Bioactivity

arecoline

SMILES	COC(=O)C1=CCCN(C)C1
InChIKey	HJJPJSXJAXAIPN-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	1
Molecular weight (Da)	155.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Ligand site mutations	M₁ M₂

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	5.70	5.70	5.70	Guide to Pharmacology
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	pKi	4.06	4.07	4.07	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	4.53	5.64	7.85	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	pKi	5.23	5.23	5.23	PDSP Ki database
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	7.54	7.96	8.39	PDSP Ki database
M₁	ACM1	Mouse	Acetylcholine (muscarinic)	A	pKi	8.26	8.37	8.48	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	pKi	5.30	5.30	5.30	Guide to Pharmacology
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	5.20	5.20	5.20	Guide to Pharmacology
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	5.61	6.69	7.40	ChEMBL
M₂	ACM2	Rat	Acetylcholine (muscarinic)	A	pKi	5.28	5.28	5.28	PDSP Ki database
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	8.62	8.62	8.62	PDSP Ki database
M₂	ACM2	Rat	Acetylcholine (muscarinic)	A	pKi	7.40	7.40	7.40	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	5.40	5.40	5.40	Guide to Pharmacology
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	4.37	4.80	5.24	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	7.37	7.37	7.37	PDSP Ki database
M₃	ACM3	Rat	Acetylcholine (muscarinic)	A	pKi	5.24	5.24	5.24	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	5.50	5.50	5.50	Guide to Pharmacology
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	7.22	7.22	7.22	PDSP Ki database
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	4.22	5.76	7.58	ChEMBL
M₄	ACM4	Rat	Acetylcholine (muscarinic)	A	pKi	5.62	5.62	5.62	ChEMBL

Showing 1 to 20 of 22 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	pIC50	4.92	6.12	7.11	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	4.19	5.80	6.94	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pEC50	5.25	5.38	5.50	ChEMBL
M₁	ACM1	Mouse	Acetylcholine (muscarinic)	A	pEC50	4.57	4.57	4.57	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	5.35	5.55	5.75	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pEC50	5.00	6.56	7.60	ChEMBL
M₂	ACM2	Rat	Acetylcholine (muscarinic)	A	pIC50	4.96	5.41	6.23	ChEMBL
M₃	ACM3	Mouse	Acetylcholine (muscarinic)	A	pEC50	4.92	4.92	4.92	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pEC50	6.47	6.73	7.00	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	4.24	4.60	4.96	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pEC50	6.89	6.89	6.89	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	4.32	4.60	4.87	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pEC50	6.22	6.22	6.22	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	4.20	4.20	4.20	ChEMBL

Showing 1 to 14 of 14 entries

arecoline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Ligand site mutations	M₁ M₂

Compound is not listed as a drug.