GPCRdb

dopamine

Agent/drug
Bioactivity

dopamine

SMILES	NCCc1ccc(O)c(O)c1
InChIKey	VYFYYTLLBUKUHU-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	3
Rotatable bonds	2
Molecular weight (Da)	153.1

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7LJD 7F0T 7F1O 7F23 7F24 7X2F 7F1Z 8TZQ 8U02 7CKZ
Ligand site mutations	α_1B α_2A β₂ 5-HT_2A D₁ D₂ D₃ D₄ D₅

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.30	8.30	8.30	Drug Central
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	8.30	8.30	8.30	Drug Central
β₂	ADRB2	Dog	Adrenoceptors	A	pKi	4.30	4.30	4.30	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKd	4.19	4.19	4.19	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	4.21	4.21	4.21	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKd	8.38	8.38	8.38	Drug Central
β₂	ADRB2	Dog	Adrenoceptors	A	pKi	8.37	8.37	8.37	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.08	5.10	5.11	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.42	6.26	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.29	8.29	8.29	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	5.00	5.04	5.22	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2C	5HT2C	Mouse	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_5A	5HT5A	Rat	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database

Showing 1 to 20 of 76 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	5.94	5.94	5.94	ChEMBL
D₁	DRD1	Bovine	Dopamine	A	pIC50	6.70	6.70	6.70	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pIC50	5.43	5.68	6.10	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pEC50	5.30	5.38	5.46	ChEMBL
D₁	DRD1	Human	Dopamine	A	pEC50	5.85	7.24	8.59	ChEMBL
D₂	DRD2	Bovine	Dopamine	A	pIC50	5.10	5.21	5.33	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	5.27	5.61	5.92	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pEC50	5.85	8.03	8.96	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	5.46	7.38	9.20	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	4.00	5.00	6.00	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pIC50	6.91	6.94	6.96	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	6.09	8.33	9.96	ChEMBL
D₄	DRD4	Rat	Dopamine	A	pEC50	8.57	8.60	8.62	ChEMBL
D₄	DRD4	Human	Dopamine	A	pEC50	6.57	7.95	8.74	ChEMBL
D₄	DRD4	Human	Dopamine	A	pIC50	6.94	6.94	6.94	ChEMBL
D₄	DRD4	Rat	Dopamine	A	pEC50	8.06	8.06	8.06	Drug Central
D₅	DRD5	Human	Dopamine	A	pEC50	8.70	8.70	8.70	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	5.77	5.77	5.77	ChEMBL

Showing 1 to 18 of 18 entries

dopamine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Endogenous
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 18

Phase III 24

Phase IV 24

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7LJD 7F0T 7F1O 7F23 7F24 7X2F 7F1Z 8TZQ 8U02 7CKZ
Ligand site mutations	α_1B α_2A β₂ 5-HT_2A D₁ D₂ D₃ D₄ D₅

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Acute myocardial infarction, unspecified	4	BA41.Z	C01C	0.601
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Congestive heart failure	4	BD10	C01C	0.600
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Diseases of the circulatory system, unspecified	4	BE2Z	C01C	0.698
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Heart failure, unspecified	2	BD1Z	C01C	0.607
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Kidney failure, unspecified	4	GB6Z	C01C	0.267
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Parkinson disease, unspecified	3	8A00.0Z	C01C	0.565
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Preterm newborn, unspecified	2	KA21.4Z	C01C	0.092
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Sepsis with septic shock	3	1G41	C01C	0.584
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Shock, unspecified	3	MG40.Z	C01C	0.581
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Symptoms and signs involving cognition, unspecified	2	MB21.Z	C01C	0.110
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Acute myocardial infarction, unspecified	4	BA41.Z	C01C	0.013
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Diseases of the circulatory system, unspecified	4	BE2Z	C01C	0.542
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Kidney failure, unspecified	4	GB6Z	C01C	0.434
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Parkinson disease, unspecified	3	8A00.0Z	C01C	0.588
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Symptoms and signs involving cognition, unspecified	2	MB21.Z	C01C	0.012
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Acute myocardial infarction, unspecified	4	BA41.Z	C01C	0.370
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Diseases of the circulatory system, unspecified	4	BE2Z	C01C	0.529
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Kidney failure, unspecified	4	GB6Z	C01C	0.462
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Parkinson disease, unspecified	3	8A00.0Z	C01C	0.621
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Preterm newborn, unspecified	2	KA21.4Z	C01C	0.388

Showing 1 to 20 of 31 entries

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dopamine

dopamine

Chemical Properties

Database connections

Bioactivities

dopamine

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information