CHEMBL1783890


SMILES CNC(=O)c1cnc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1
InChIKey DGWKVXVCPCPOAK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 352.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Rat Histamine A pKi 8.95 9.02 9.08 ChEMBL
H1 HRH1 Human Histamine A pKi 5.8 5.8 5.8 ChEMBL
H3 HRH3 Human Histamine A pKi 9.67 9.69 9.72 ChEMBL
H3 HRH3 Human Histamine A pKd 9.26 9.26 9.26 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pIC50 9.2 9.2 9.2 ChEMBL