GPCRdb

thioperamide

Agent/drug
Bioactivity

thioperamide

SMILES	S=C(NC1CCCCC1)N1CCC(c2cnc[nH]2)CC1
InChIKey	QKDDJDBFONZGBW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	2
Rotatable bonds	2
Molecular weight (Da)	292.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	H₃ H₄

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.90	6.90	6.90	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.90	6.90	6.90	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.46	6.46	6.46	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.46	6.46	6.46	PDSP Ki database
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
δ	OPRD	Rat	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
κ	OPRK	Rat	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
μ	OPRM	Rat	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	5HT1D	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT₄	5HT4R	Guinea pig	5-Hydroxytryptamine	A	pKi	5.55	5.55	5.55	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₃	DRD3	Rat	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
H₁	HRH1	Guinea pig	Histamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
H₂	HRH2	Human	Histamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
H₂	HRH2	Guinea pig	Histamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
H₃	HRH3	Rat	Histamine	A	pKi	7.70	8.25	8.80	Guide to Pharmacology

Showing 1 to 20 of 41 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₃	HRH3	Mouse	Histamine	A	pEC50	7.96	7.96	7.96	ChEMBL
H₃	HRH3	Human	Histamine	A	pIC50	5.99	7.10	8.71	ChEMBL
H₃	HRH3	Human	Histamine	A	pEC50	7.00	7.18	7.47	ChEMBL
H₄	HRH4	Mouse	Histamine	A	pEC50	6.52	7.04	7.55	ChEMBL
H₄	HRH4	Human	Histamine	A	pIC50	6.01	6.48	7.72	ChEMBL
H₄	HRH4	Human	Histamine	A	pEC50	6.38	6.96	7.15	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.70	4.78	4.85	ChEMBL

Showing 1 to 7 of 7 entries

thioperamide

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	H₃ H₄

Compound is not listed as a drug.