GPCRdb

METHAMPHETAMINE

Agent/drug
Bioactivity

METHAMPHETAMINE

SMILES	CN[C@@H](C)Cc1ccccc1
InChIKey	MYWUZJCMWCOHBA-VIFPVBQESA-N

Chemical Properties

Hydrogen bond acceptors	1
Hydrogen bond donors	1
Rotatable bonds	3
Molecular weight (Da)	149.1

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	9JKQ 8W87

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.38	5.38	5.38	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.27	8.27	8.27	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.13	6.13	6.13	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.09	6.09	6.09	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.30	8.30	8.30	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 12 of 12 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

TA₁	TAAR1	Rhesus macaque	Trace amine	A	pEC50	5.28	5.28	5.28	ChEMBL
TA₁	TAAR1	Rat	Trace amine	A	pEC50	5.69	6.33	6.88	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	5.82	5.86	5.89	ChEMBL
TA₁	TAAR1	Mouse	Trace amine	A	pEC50	5.74	6.65	7.75	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	8.23	8.23	8.23	Drug Central
TA₁	TAAR1	Rat	Trace amine	A	pEC50	8.16	8.16	8.16	Drug Central
TA₁	TAAR1	Mouse	Trace amine	A	pEC50	8.15	8.15	8.15	Drug Central
TA₁	TAAR1	Rhesus macaque	Trace amine	A	pEC50	8.28	8.28	8.28	Drug Central

Showing 1 to 8 of 8 entries

METHAMPHETAMINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	9JKQ 8W87

Compound is not listed as a drug.