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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(+)-chlorpheniramine	918	None	42	Human	Binding	Ki	=	749.00	6.13	-144	27	DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274.1	5	0	2	3.82	CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1	-
(+)-chlorpheniramine	918	None	42	Human	Binding	IC50	=	1043.00	5.98	-144	27	DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274.1	5	0	2	3.82	CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1	-
(+)-chlorpheniramine	918	None	42	Human	Binding	AC50	=	6117.70	5.21	-144	27	Binding affinity towards human CHRM5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274.1	5	0	2	3.82	CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1	https://dx.doi.org/10.1038/s41467-023-40064-9
(+)-chlorpheniramine	918	None	42	Human	Binding	pKi	=	6.13	8.21	-144	27	DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274.1	5	0	2	3.82	CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1	-
(-)-stepholidine	3691	3H-QNB	40	Human	Binding	pKi	=	10000.00	5.00	-2290	35	-	PDSP KiDatabase	327.1	2	2	5	2.77	COc1cc2c(cc1O)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	-
(1R,2S)-PHENYLPROPANOLAMINE	27120	3H-QNB	13	Human	Binding	pKi	=	10000.00	5.00	-38	42	-	PDSP KiDatabase	151.1	2	2	2	1.07	C[C@H](N)[C@H](O)c1ccccc1	-
(R)-Hexbutinol	218743	3H-NMS	0	Human	Binding	pKi	=	75.86	7.12	-2	5	-	PDSP KiDatabase	311.2	3	1	2	3.94	OC(C#CCN1CCCCC1)(c1ccccc1)C1CCCCC1	-
(R)-Hexbutinol	218743	3H-NMS	0	Human	Binding	pKi	=	5.50	8.26	-2	5	-	PDSP KiDatabase	311.2	3	1	2	3.94	OC(C#CCN1CCCCC1)(c1ccccc1)C1CCCCC1	-
(S)-(+)-DIMETHINDENE	199081	None	3	Human	Binding	Ki	=	2691.53	5.57	-6456	6	Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292.2	5	0	2	4.15	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	https://dx.doi.org/10.1021/jm020895l
(S)-dimetindene	3566	None	10	Human	Binding	pKi	=	-	6.12	-25	7	Binding to hM5 receptors expressed in CHO cells.	Guide to Pharmacology	292.2	5	0	2	4.15	C[C@@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	https://pubmed.ncbi.nlm.nih.gov/12593665
(S)-dimetindene	3566	None	10	Human	Binding	Ki	=	758.58	6.12	-25	7	Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292.2	5	0	2	4.15	C[C@@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	https://dx.doi.org/10.1021/jm020895l
3,3'-difluorobenzaldazine	91	None	30	Human	Binding	EC50	=	2600.00	5.58	-	2	Positive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader	ChEMBL	244.1	3	0	2	3.42	Fc1cccc(/C=N/N=C/c2cccc(F)c2)c1	https://dx.doi.org/10.1021/jm5011786
3-quinuclidinyl-benzilate	112	None	21	Human	Binding	pKd	=	-	10.46	-1	7	Unclassified	Guide to Pharmacology	337.2	4	1	4	2.56	O=C(OC1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	https://pubmed.ncbi.nlm.nih.gov/7562472
3-quinuclidinyl-benzilate	112	3H-QNB	21	Human	Binding	pKi	=	0.04	10.37	-1	7	-	PDSP KiDatabase	337.2	4	1	4	2.56	O=C(OC1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	-
3-quinuclidinyl-benzilate	112	3H-QNB	21	Human	Binding	pKi	=	0.07	10.19	-1	7	-	PDSP KiDatabase	337.2	4	1	4	2.56	O=C(OC1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	-
4-DAMP	116	None	5	Human	Binding	pKi	=	-	9.00	-1	12	Unclassified	Guide to Pharmacology	324.2	4	0	2	3.60	C[N+]1(C)CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	https://pubmed.ncbi.nlm.nih.gov/1994002
4-DAMP	116	3H-NMS	5	Human	Binding	pKi	=	1.05	8.98	-1	12	-	PDSP KiDatabase	324.2	4	0	2	3.60	C[N+]1(C)CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	-
4-DAMP	116	None	5	Human	Binding	IC50	=	0.32	9.49	-1	12	Displacement of [3H]4-DAMP from human recombinant M5 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	324.2	4	0	2	3.60	C[N+]1(C)CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	https://dx.doi.org/10.1016/j.bmc.2016.11.014
4-DAMP	116	None	5	Human	Binding	IC50	=	0.32	9.49	-1	12	Displacement of [3H]4-DAMP from human recombinant muscarinic M5 receptor expressed in CHO cells	ChEMBL	324.2	4	0	2	3.60	C[N+]1(C)CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	https://dx.doi.org/10.1016/j.bmc.2016.03.006
4-DAMP	116	None	5	Human	Binding	Ki	=	0.48	9.32	-1	12	Displacement of [3H]4-DAMP from human recombinant M5 receptor expressed in CHO cells	ChEMBL	324.2	4	0	2	3.60	C[N+]1(C)CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	https://dx.doi.org/10.1021/jm401895u

Showing 1 to 20 of 1,439 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)