GPCRdb

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Ligand source activities (1 row/activity)

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Potency

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[Leu³¹,Pro³⁴]NPY	2302	None	0	Rat	Binding	pKi	None	-	10.60	50	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9145427
[Leu³¹,Pro³⁴]PYY (human)	2304	None	0	Rat	Binding	pKi	None	-	10.20	1	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9145427
[Leu³¹,Pro³⁴]PYY (pig)	2305	None	0	Human	Binding	IC50	=	2.69	8.57	-	5	Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm000052z
ABT-594	219818	125I-Peptide YY	0	Human	Binding	pKi	=	1000.00	6.00	-2	37	-	PDSP KiDatabase	198.1	3	1	3	1.48	Clc1ccc(OCC2CCN2)cn1	-
AMSACRINE	167616	None	49	Human	Binding	AC50	=	9299.90	5.03	-	15	Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	393.1	5	2	5	4.51	COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12	https://dx.doi.org/10.1038/s41467-023-40064-9
ANETHOLTRITHION	63103	None	64	Human	Binding	AC50	=	9800.10	5.01	-	10	Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	240.0	2	0	4	4.21	COc1ccc(-c2cc(=S)ss2)cc1	https://dx.doi.org/10.1038/s41467-023-40064-9
ATOMOXETINE	205585	UNDEFINED	33	Human	Binding	pKi	=	1000.00	6.00	-1	37	-	PDSP KiDatabase	255.2	6	1	2	3.73	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	-
BENEXTRAMINE	67670	None	3	Human	Binding	Ki	=	1800.00	5.75	2	2	Binding affinity to NPY1 receptor	ChEMBL	590.4	27	4	8	6.26	COc1ccccc1CNCCCCCCNCCSSCCNCCCCCCNCc1ccccc1OC	https://dx.doi.org/10.1016/j.bmcl.2011.06.124
BENSERAZIDE	8844	None	30	Human	Binding	AC50	=	5670.00	5.25	-	4	Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	257.1	5	7	7	-1.76	NC(CO)C(=O)NNCc1ccc(O)c(O)c1O	https://dx.doi.org/10.1038/s41467-023-40064-9
BENZETHONIUM	11852	None	18	Human	Binding	AC50	=	15000.00	4.82	-	35	Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412.3	11	0	2	6.07	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	https://dx.doi.org/10.1038/s41467-023-40064-9
BIBO3304	630	None	18	Human	Binding	IC50	=	0.38	9.42	-	4	Radioligand binding assay (NPY1R, SK-N-MC)	ChEMBL	529.3	13	6	4	1.84	NC(=O)NCc1ccc(CNC(=O)[C@@H](CCCN=C(N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1	https://dx.doi.org/10.6019/CHEMBL5463723
BIBO3304	630	None	18	Human	Binding	IC50	=	0.69	9.16	-	4	Radioligand binding assay (NPY1R, BHK)	ChEMBL	529.3	13	6	4	1.84	NC(=O)NCc1ccc(CNC(=O)[C@@H](CCCN=C(N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1	https://dx.doi.org/10.6019/CHEMBL5463723
BIBO3304	630	None	18	Human	Binding	Ki	=	0.25	9.60	-	4	Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells	ChEMBL	529.3	13	6	4	1.84	NC(=O)NCc1ccc(CNC(=O)[C@@H](CCCN=C(N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1	https://dx.doi.org/10.1016/j.bmc.2011.03.045
BIBO3304	630	None	18	Rat	Binding	IC50	=	0.72	9.14	-	4	Radioligand binding assay (NPY1R, HEK293, rat)	ChEMBL	529.3	13	6	4	1.84	NC(=O)NCc1ccc(CNC(=O)[C@@H](CCCN=C(N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1	https://dx.doi.org/10.6019/CHEMBL5463723
BIBP3226	631	None	27	Human	Binding	pKi	=	-	8.72	1	4	Unclassified	Guide to Pharmacology	473.2	11	5	4	2.38	NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1	https://pubmed.ncbi.nlm.nih.gov/7562541
BIBP3226	631	None	27	Human	Binding	pKi	=	-	8.72	1	4	Unclassified	Guide to Pharmacology	473.2	11	5	4	2.38	NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1	https://pubmed.ncbi.nlm.nih.gov/7562543
BIBP3226	631	None	27	Human	Binding	pKd	=	-	8.70	1	4	Unclassified	Guide to Pharmacology	473.2	11	5	4	2.38	NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1	-
BIBP3226	631	None	27	Human	Binding	Ki	=	5.10	8.29	1	4	Displacement of radiolabeled NPY from human Y1R expressed in human SK-N-MC cells	ChEMBL	473.2	11	5	4	2.38	NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1	https://dx.doi.org/10.1016/j.bmc.2011.03.045
BIBP3226	631	None	27	Human	Binding	Kd	=	2.10	8.68	1	4	Binding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assay	ChEMBL	473.2	11	5	4	2.38	NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1	https://dx.doi.org/10.1021/acs.jmedchem.5b00925
BIBP3226	631	None	27	Human	Binding	Ki	=	1.50	8.82	1	4	Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis	ChEMBL	473.2	11	5	4	2.38	NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1	https://dx.doi.org/10.1021/acs.jmedchem.5b00925

Showing 1 to 20 of 1,033 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)