GPCRdb

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(D-Thr⁶, D-Trp^8,9)galanin(1-15)ol	1494	None	0	Rat	Binding	pKi	>	-	5.90	-1	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9281594
[D-Trp²]galanin-(1-29)	1499	None	0	Human	Binding	Kd	=	2.30	8.64	-5	4	Binding affinity to human GalR2	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm801088x
[D-Trp²]galanin-(1-29)	1499	None	0	Rat	Binding	pKi	=	-	8.15	-17	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9305929
[N-Me,des-Sar]Gal-B2	2832	None	0	Human	Binding	pKi	=	-	7.69	17	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/20121116
C7	777	None	0	Human	Binding	pKi	=	-	8.95	-4	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9880084
C7	777	None	0	Human	Binding	pKi	=	-	8.95	-4	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9480833
C7	777	None	0	Rat	Binding	pKi	=	-	8.48	-13	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9305929
C7	777	None	0	Rat	Binding	pKi	=	-	8.48	-13	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9722565
C7	777	None	0	Rat	Binding	pKi	=	-	8.48	-13	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9281594
C7	777	None	0	Rat	Binding	pKi	=	-	8.48	-13	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9832122
C7	777	None	0	Mouse	Binding	pKi	=	-	7.85	-58	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9832122
CHEMBL1790054	63205	None	0	Human	Binding	Ki	=	65.50	7.18	-19	2	Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells	ChEMBL	2195.3	78	32	26	-3.15	CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	https://dx.doi.org/10.1021/jm801088x
CHEMBL1921901	68764	None	0	Human	Binding	IC50	=	4570.00	5.34	-	1	Displacement of [125I]galanin from GalR2 by gamma counting	ChEMBL	373.2	5	2	5	5.57	Cc1ccc(C)c(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1	https://dx.doi.org/10.1016/j.bmcl.2011.09.033
CHEMBL1921902	68765	None	0	Human	Binding	IC50	=	1090.00	5.96	-	2	Displacement of [125I]galanin from GalR2 by gamma counting	ChEMBL	375.2	6	2	6	4.96	COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.09.033
CHEMBL1921903	68766	None	0	Human	Binding	IC50	=	6620.00	5.18	-	2	Displacement of [125I]galanin from GalR2 by gamma counting	ChEMBL	429.2	6	2	6	5.85	FC(F)(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1	https://dx.doi.org/10.1016/j.bmcl.2011.09.033
CHEMBL1921988	68817	None	0	Human	Binding	IC50	=	3380.00	5.47	-	1	Displacement of [125I]galanin from GalR2 by gamma counting	ChEMBL	411.2	7	2	6	5.56	FC(F)Oc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.09.033
CHEMBL1921989	68818	None	0	Human	Binding	IC50	=	4150.00	5.38	-	2	Displacement of [125I]galanin from GalR2 by gamma counting	ChEMBL	411.2	7	2	6	5.56	FC(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1	https://dx.doi.org/10.1016/j.bmcl.2011.09.033
CHEMBL1921990	68819	None	0	Human	Binding	IC50	=	3690.00	5.43	-	1	Displacement of [125I]galanin from GalR2 by gamma counting	ChEMBL	403.2	6	2	7	4.55	c1ccc(Nc2cc(NCc3ccc4c(c3)OCO4)nc(N3CCCCC3)n2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.09.033
CHEMBL1921991	68820	None	0	Human	Binding	IC50	=	8650.00	5.06	-	2	Displacement of [125I]galanin from GalR2 by gamma counting	ChEMBL	393.2	6	2	6	5.10	COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1F	https://dx.doi.org/10.1016/j.bmcl.2011.09.033
CHEMBL1921992	68821	None	0	Human	Binding	IC50	=	3400.00	5.47	-	2	Displacement of [125I]galanin from GalR2 by gamma counting	ChEMBL	430.2	6	1	7	4.16	COc1ccc(Nc2cc(N3CCN(c4ccccc4)CC3)nc(N3CCCC3)n2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.09.033

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[Sar¹, D-Ala¹²]galanin(1-16)	3482	None	0	Rat	Functional	pIC50	=	-	8.76	-4	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11481429
alarin	327	None	0	Rat	Functional	pIC50	>	-	6.00	-1	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/20880399
C7	777	None	0	Human	Functional	pEC50	=	-	8.03	-3	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9880084
C7	777	None	0	Human	Functional	pIC50	=	-	8.08	-3	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9685625
C7	777	None	0	Rat	Functional	pEC50	=	-	8.52	-2	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9305929
C7	777	None	0	Rat	Functional	pIC50	=	-	8.04	-2	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9427506
C7	777	None	0	Rat	Functional	pIC50	=	-	8.04	-2	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9108306
CHEMBL1342746	24588	None	5	Human	Functional	IC50	=	45640.00	4.34	-	1	PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]	ChEMBL	343.1	2	1	5	2.48	CCOC(=O)N1CCN(c2[nH]cnc3c4cc(F)ccc4nc2-3)CC1	-
CHEMBL1374788	28365	None	3	Human	Functional	IC50	=	7616.00	5.12	-5	3	PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]	ChEMBL	396.1	6	1	5	2.21	CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O	-
CHEMBL1374788	28365	None	3	Human	Functional	IC50	=	17100.00	4.77	-5	3	PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]	ChEMBL	396.1	6	1	5	2.21	CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O	-
CHEMBL1400481	31177	None	3	Human	Functional	IC50	=	8959.00	5.05	2	3	PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]	ChEMBL	252.0	3	0	7	2.02	O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1	-
CHEMBL1400481	31177	None	3	Human	Functional	IC50	=	9608.00	5.02	2	3	PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]	ChEMBL	252.0	3	0	7	2.02	O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1	-
CHEMBL1408432	32077	None	3	Human	Functional	EC50	=	45422.00	4.34	-	1	PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify agonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 864 ]	ChEMBL	360.1	6	1	5	3.81	C=CCNC(=O)/C(C#N)=C/c1cn(-c2ccccc2)nc1-c1cccs1	-
CHEMBL1432794	34996	None	6	Human	Functional	IC50	=	6765.00	5.17	-	1	PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]	ChEMBL	425.1	5	3	4	4.71	O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1ccc(NC(=O)c2ccco2)cc1	-
CHEMBL1447697	36512	None	3	Human	Functional	IC50	=	10320.00	4.99	1	3	PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]	ChEMBL	297.1	5	1	7	1.64	CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O	-
CHEMBL1447697	36512	None	3	Human	Functional	IC50	=	7528.00	5.12	1	3	PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]	ChEMBL	297.1	5	1	7	1.64	CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O	-
CHEMBL1451772	37021	None	17	Human	Functional	IC50	=	8838.00	5.05	1	2	PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]	ChEMBL	326.1	3	1	4	3.69	CN(C)c1ccc(NC2=C(Cl)C(=O)c3ccccc3C2=O)cc1	-
CHEMBL1458812	37853	None	16	Human	Functional	IC50	=	14420.00	4.84	-1	2	PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]	ChEMBL	306.1	4	0	6	2.90	CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12	-
CHEMBL1458812	37853	None	16	Human	Functional	IC50	=	17070.00	4.77	-1	2	PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]	ChEMBL	306.1	4	0	6	2.90	CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12	-
CHEMBL1482215	40436	None	0	Human	Functional	IC50	=	45250.00	4.34	-	1	PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]	ChEMBL	337.1	3	2	5	5.43	Nc1[nH]c(N=Nc2nc(-c3ccc(F)cc3)cs2)c2ccccc12	-

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Ligand source activities (1 row/activity)