Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
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Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
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Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
1902746 | 32067 | None | 7 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify agonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 864 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify agonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 864 ] |
ChEMBL | 360 | 6 | 1 | 5 | 3.8 | C=CCNC(=O)/C(C#N)=C/c1cn(-c2ccccc2)nc1-c1cccs1 | nan | ||
CHEMBL1408432 | 32067 | None | 7 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify agonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 864 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify agonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 864 ] |
ChEMBL | 360 | 6 | 1 | 5 | 3.8 | C=CCNC(=O)/C(C#N)=C/c1cn(-c2ccccc2)nc1-c1cccs1 | nan | ||
4104905 | 36500 | None | 6 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 1 | 3 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 297 | 5 | 1 | 7 | 1.6 | CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O | nan | ||
CHEMBL1447697 | 36500 | None | 6 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 1 | 3 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 297 | 5 | 1 | 7 | 1.6 | CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O | nan | ||
1478923 | 51973 | None | 17 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -1 | 2 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 265 | 4 | 1 | 4 | 2.9 | O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 | nan | ||
CHEMBL1586531 | 51973 | None | 17 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -1 | 2 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 265 | 4 | 1 | 4 | 2.9 | O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 | nan | ||
638439 | 103797 | None | 70 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 2 | 2 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 195 | 3 | 1 | 4 | 1.6 | COc1cc(/C=C/[N+](=O)[O-])ccc1O | nan | ||
CHEMBL309016 | 103797 | None | 70 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 2 | 2 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 195 | 3 | 1 | 4 | 1.6 | COc1cc(/C=C/[N+](=O)[O-])ccc1O | nan | ||
4686258 | 51844 | None | 7 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 278 | 4 | 2 | 8 | 1.5 | CNc1nc2cc([N+](=O)[O-])c([N+](=O)[O-])cc2nc1NC | nan | ||
CHEMBL1585420 | 51844 | None | 7 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 278 | 4 | 2 | 8 | 1.5 | CNc1nc2cc([N+](=O)[O-])c([N+](=O)[O-])cc2nc1NC | nan | ||
3775080 | 37840 | None | 18 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 306 | 4 | 0 | 6 | 2.9 | CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 | nan | ||
CHEMBL1458812 | 37840 | None | 18 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 306 | 4 | 0 | 6 | 2.9 | CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 | nan | ||
1478923 | 51973 | None | 17 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 265 | 4 | 1 | 4 | 2.9 | O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 | nan | ||
CHEMBL1586531 | 51973 | None | 17 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 265 | 4 | 1 | 4 | 2.9 | O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 | nan | ||
3775080 | 37840 | None | 18 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 306 | 4 | 0 | 6 | 2.9 | CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 | nan | ||
CHEMBL1458812 | 37840 | None | 18 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 306 | 4 | 0 | 6 | 2.9 | CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 | nan | ||
2585250 | 28355 | None | 6 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -5 | 3 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 396 | 6 | 1 | 5 | 2.2 | CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O | nan | ||
CHEMBL1374788 | 28355 | None | 6 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -5 | 3 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 396 | 6 | 1 | 5 | 2.2 | CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O | nan | ||
5335764 | 45910 | None | 9 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 | nan | ||
CHEMBL1531933 | 45910 | None | 9 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 | nan | ||
5335764 | 45910 | None | 9 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 | nan | ||
CHEMBL1531933 | 45910 | None | 9 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 | nan | ||
5064340 | 40421 | None | 1 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 337 | 3 | 2 | 5 | 5.4 | Nc1[nH]c(N=Nc2nc(-c3ccc(F)cc3)cs2)c2ccccc12 | nan | ||
CHEMBL1482215 | 40421 | None | 1 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 337 | 3 | 2 | 5 | 5.4 | Nc1[nH]c(N=Nc2nc(-c3ccc(F)cc3)cs2)c2ccccc12 | nan | ||
919665 | 24578 | None | 7 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 343 | 2 | 1 | 5 | 2.5 | CCOC(=O)N1CCN(c2[nH]cnc3c4cc(F)ccc4nc2-3)CC1 | nan | ||
CHEMBL1342746 | 24578 | None | 7 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 343 | 2 | 1 | 5 | 2.5 | CCOC(=O)N1CCN(c2[nH]cnc3c4cc(F)ccc4nc2-3)CC1 | nan | ||
2585042 | 46843 | None | 6 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -3 | 4 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 480 | 4 | 0 | 6 | 2.2 | O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 | nan | ||
CHEMBL1540377 | 46843 | None | 6 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -3 | 4 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 480 | 4 | 0 | 6 | 2.2 | O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 | nan | ||
1345012 | 34985 | None | 9 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 425 | 5 | 3 | 4 | 4.7 | O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1ccc(NC(=O)c2ccco2)cc1 | nan | ||
CHEMBL1432794 | 34985 | None | 9 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 425 | 5 | 3 | 4 | 4.7 | O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1ccc(NC(=O)c2ccco2)cc1 | nan | ||
4104905 | 36500 | None | 6 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 1 | 3 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 297 | 5 | 1 | 7 | 1.6 | CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O | nan | ||
CHEMBL1447697 | 36500 | None | 6 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 1 | 3 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 297 | 5 | 1 | 7 | 1.6 | CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O | nan | ||
2585250 | 28355 | None | 6 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -5 | 3 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 396 | 6 | 1 | 5 | 2.2 | CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O | nan | ||
CHEMBL1374788 | 28355 | None | 6 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -5 | 3 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 396 | 6 | 1 | 5 | 2.2 | CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O | nan | ||
260557 | 37008 | None | 19 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 1 | 2 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 326 | 3 | 1 | 4 | 3.7 | CN(C)c1ccc(NC2=C(Cl)C(=O)c3ccccc3C2=O)cc1 | nan | ||
CHEMBL1451772 | 37008 | None | 19 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 1 | 2 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 326 | 3 | 1 | 4 | 3.7 | CN(C)c1ccc(NC2=C(Cl)C(=O)c3ccccc3C2=O)cc1 | nan | ||
3319616 | 31167 | None | 3 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 2 | 3 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 252 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 | nan | ||
CHEMBL1400481 | 31167 | None | 3 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 2 | 3 | PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] |
ChEMBL | 252 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 | nan | ||
3319616 | 31167 | None | 3 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 2 | 3 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 252 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 | nan | ||
CHEMBL1400481 | 31167 | None | 3 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 2 | 3 | PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] |
ChEMBL | 252 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 | nan | ||
11417 | 3646 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 3 | 2 | Determined by measuring SRE-luc activity in HEK293-Gqi cells expressing hGALR2.Determined by measuring SRE-luc activity in HEK293-Gqi cells expressing hGALR2. |
Guide to Pharmacology | None | None | None | None | 24517231 | ||||
8547 | 1291 | None | 0 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Potentiation of galanin-induced IP1 accumulation <i>in vitro</i>.Potentiation of galanin-induced IP1 accumulation <i>in vitro</i>. |
Guide to Pharmacology | 765 | 13 | 5 | 7 | 7.3 | O=C(N[C@H](C(=O)N[C@H](C(=O)Nc1ccc2c(c1)[nH]c(=O)cc2C)CCCNC(=O)OC(C)(C)C)CC1CCCCC1)OCC1C2C=CC=CC2c2c1cccc2 | 20660766 | ||
91827369 | 1291 | None | 0 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Potentiation of galanin-induced IP1 accumulation <i>in vitro</i>.Potentiation of galanin-induced IP1 accumulation <i>in vitro</i>. |
Guide to Pharmacology | 765 | 13 | 5 | 7 | 7.3 | O=C(N[C@H](C(=O)N[C@H](C(=O)Nc1ccc2c(c1)[nH]c(=O)cc2C)CCCNC(=O)OC(C)(C)C)CC1CCCCC1)OCC1C2C=CC=CC2c2c1cccc2 | 20660766 | ||
11419 | 3262 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | SRE-luc reporter activation in HEK293 Gqi cells expressing hGAL<sub>3</sub> receptor.SRE-luc reporter activation in HEK293 Gqi cells expressing hGAL<sub>3</sub> receptor. |
Guide to Pharmacology | None | None | None | None | 32231393 | ||||
6095 | 1737 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -2 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 9880084 | ||||
3896 | 2441 | None | 0 | Rat | Functional | pEC50 | = | 6.5 | 6.5 | -58 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 9305929 | ||||
6095 | 1737 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | 2 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 9305929 | ||||
16132180 | 1722 | None | 21 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | -89 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 9305929 | ||||
16133822 | 1722 | None | 21 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | -89 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 9305929 | ||||
6087 | 1722 | None | 21 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | -89 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 9305929 |
Showing 1 to 50 of 231 entries
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
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Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
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Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
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Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
72548703 | 161565 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | Displacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysisDisplacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysis |
ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | ||
CHEMBL4128926 | 161565 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | Displacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysisDisplacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysis |
ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | ||
CHEMBL501079 | 214128 | None | 13 | Human | Binding | pIC50 | = | 9.1 | 9.1 | -11 | 2 | Binding affinity to human GAL2 receptor by radioligand displacement assayBinding affinity to human GAL2 receptor by radioligand displacement assay |
ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1016/j.bmc.2013.03.016 | ||||
57392517 | 68802 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 473 | 8 | 3 | 7 | 6.6 | COc1ccc(Nc2cc(Nc3ccc(OC(F)(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1921997 | 68802 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 473 | 8 | 3 | 7 | 6.6 | COc1ccc(Nc2cc(Nc3ccc(OC(F)(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
57396058 | 68741 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 375 | 6 | 2 | 6 | 5.0 | COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1921902 | 68741 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 375 | 6 | 2 | 6 | 5.0 | COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
57401222 | 68810 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 403 | 6 | 2 | 6 | 5.6 | COc1ccc(Nc2nc(Nc3ccc(C)cc3C)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1922004 | 68810 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 403 | 6 | 2 | 6 | 5.6 | COc1ccc(Nc2nc(Nc3ccc(C)cc3C)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
57395993 | 68800 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 455 | 9 | 3 | 7 | 6.3 | COc1ccc(Nc2cc(Nc3ccc(OC(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1921995 | 68800 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 455 | 9 | 3 | 7 | 6.3 | COc1ccc(Nc2cc(Nc3ccc(OC(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
57401225 | 68823 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 437 | 7 | 2 | 7 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCC(C)C3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1922019 | 68823 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 437 | 7 | 2 | 7 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCC(C)C3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
57394237 | 68803 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 419 | 8 | 3 | 7 | 5.7 | COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1921998 | 68803 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 419 | 8 | 3 | 7 | 5.7 | COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
57397798 | 68806 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 527 | 6 | 1 | 8 | 5.4 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1922000 | 68806 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 527 | 6 | 1 | 8 | 5.4 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
57392518 | 68817 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 457 | 7 | 2 | 6 | 5.9 | COc1ccc(Nc2nc(NCc3cccc(C(F)(F)F)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1922011 | 68817 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 457 | 7 | 2 | 6 | 5.9 | COc1ccc(Nc2nc(NCc3cccc(C(F)(F)F)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL501079 | 214128 | None | 13 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -11 | 2 | Binding affinity to human GAL2 receptor by radioligand displacement assayBinding affinity to human GAL2 receptor by radioligand displacement assay |
ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1016/j.ejmech.2013.01.044 | ||||
101927062 | 1714 | None | 22 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
155817445 | 1714 | None | 22 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
16133823 | 1714 | None | 22 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
3592 | 1714 | None | 22 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
44584852 | 1714 | None | 22 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
6090 | 1714 | None | 22 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
91898917 | 1714 | None | 22 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
CHEMBL506553 | 1714 | None | 22 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
57399458 | 68808 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 545 | 6 | 1 | 8 | 5.5 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1F | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1922002 | 68808 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 545 | 6 | 1 | 8 | 5.5 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1F | 10.1016/j.bmcl.2011.09.033 | ||
57395994 | 68807 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 525 | 5 | 1 | 7 | 6.0 | Cc1ccc(C)c(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1922001 | 68807 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 525 | 5 | 1 | 7 | 6.0 | Cc1ccc(C)c(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | ||
16078939 | 180710 | None | 21 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells |
ChEMBL | 395 | 9 | 2 | 4 | 3.9 | N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(=O)O | 10.1016/j.bmcl.2008.10.104 | ||
CHEMBL475562 | 180710 | None | 21 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells |
ChEMBL | 395 | 9 | 2 | 4 | 3.9 | N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(=O)O | 10.1016/j.bmcl.2008.10.104 | ||
CHEMBL514318 | 215593 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells |
ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)CC)NC1=O | 10.1016/j.bmcl.2008.10.104 | ||||
CHEMBL475845 | 214041 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells |
ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](CS(=O)(=O)O)C(C)=O)NC(=O)[C@H]([C@@H](C)CC)NC1=O | 10.1016/j.bmcl.2008.10.104 | ||||
57390718 | 68826 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 500 | 8 | 2 | 8 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCN(c4ccccc4)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1922023 | 68826 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 500 | 8 | 2 | 8 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCN(c4ccccc4)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL515145 | 215595 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells |
ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H]([C@@H](C)CC)NC1=O | 10.1016/j.bmcl.2008.10.104 | ||||
57401223 | 68822 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 411 | 9 | 2 | 7 | 5.0 | CCN(CC)c1cc(Nc2ccc(OC)c(F)c2)nc(Nc2ccc(OC)cc2)n1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1922017 | 68822 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 411 | 9 | 2 | 7 | 5.0 | CCN(CC)c1cc(Nc2ccc(OC)c(F)c2)nc(Nc2ccc(OC)cc2)n1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL501079 | 214128 | None | 13 | Human | Binding | pIC50 | = | 8.5 | 8.5 | -11 | 2 | Displacement of radiolabeled galanin from human galanin 2 receptorDisplacement of radiolabeled galanin from human galanin 2 receptor |
ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm8007618 | ||||
CHEMBL501079 | 214128 | None | 13 | Human | Binding | pIC50 | = | 8.5 | 8.5 | -11 | 2 | Inhibition of human GAL2 receptorInhibition of human GAL2 receptor |
ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm701575k | ||||
54764411 | 68813 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 459 | 7 | 2 | 7 | 5.9 | COc1ccc(Nc2nc(Nc3ccc(OC(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1922007 | 68813 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 459 | 7 | 2 | 7 | 5.9 | COc1ccc(Nc2nc(Nc3ccc(OC(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
57394235 | 68793 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 411 | 7 | 2 | 6 | 5.6 | FC(F)Oc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1921988 | 68793 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 411 | 7 | 2 | 6 | 5.6 | FC(F)Oc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
57399456 | 68797 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 430 | 6 | 1 | 7 | 4.2 | COc1ccc(Nc2cc(N3CCN(c4ccccc4)CC3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
CHEMBL1921992 | 68797 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 430 | 6 | 1 | 7 | 4.2 | COc1ccc(Nc2cc(N3CCN(c4ccccc4)CC3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
57397796 | 68795 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting |
ChEMBL | 403 | 6 | 2 | 7 | 4.6 | c1ccc(Nc2cc(NCc3ccc4c(c3)OCO4)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 |
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