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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

α-ergocryptine	358	None	18	Human	Binding	pKi	=	8.09	8.09	-6	21	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575.3	5	3	6	2.43	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	-
α-ergocryptine	358	None	18	Human	Binding	Ki	=	8.22	8.09	-6	21	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575.3	5	3	6	2.43	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	-
α-ergocryptine	358	None	18	Human	Binding	IC50	=	13.00	7.89	-6	21	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575.3	5	3	6	2.43	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	-
α-methyl-5-HT	364	None	24	Human	Binding	pKi	None	-	8.10	1	19	Unclassified	Guide to Pharmacology	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	https://pubmed.ncbi.nlm.nih.gov/15322733
α-methyl-5-HT	364	None	24	Human	Binding	pKi	None	-	8.10	1	19	Unclassified	Guide to Pharmacology	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	https://pubmed.ncbi.nlm.nih.gov/8078486
α-methyl-5-HT	364	None	24	Human	Binding	pKi	None	-	8.10	1	19	Unclassified	Guide to Pharmacology	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	https://pubmed.ncbi.nlm.nih.gov/15466450
α-methyl-5-HT	364	None	24	Human	Binding	Ki	=	13.00	7.89	1	19	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	https://dx.doi.org/10.1021/jm030205t
α-methyl-5-HT	364	None	24	Human	Binding	Ki	=	13.00	7.89	1	19	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	https://dx.doi.org/10.1021/jm050663x
α-methyl-5-HT	364	3H-5HT	24	Human	Binding	pKi	=	11.50	7.94	1	19	-	PDSP KiDatabase	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	-
α-methyl-5-HT	364	3H-5HT	24	Human	Binding	pKi	=	11.90	7.92	1	19	-	PDSP KiDatabase	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	-
α-methyl-5-HT	364	Functional	24	Human	Binding	pKi	=	2.00	8.70	1	19	-	PDSP KiDatabase	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	-
α-methyl-5-HT	364	3H-5HT	24	Human	Binding	pKi	=	6.92	8.16	1	19	-	PDSP KiDatabase	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	-
α-methyl-5-HT	364	None	24	Rat	Binding	pKi	None	-	8.00	-1	19	Unclassified	Guide to Pharmacology	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	https://pubmed.ncbi.nlm.nih.gov/8450835
α-methyl-5-HT	364	3H-5HT	24	Rat	Binding	pKi	=	10.50	7.98	-1	19	-	PDSP KiDatabase	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	-
α-methyl-5-HT	364	3H-5HT	24	Rat	Binding	pKi	=	10.50	7.98	-1	19	-	PDSP KiDatabase	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	-
α-methyl-5-HT	364	3H-5HT	24	Rat	Binding	pKi	=	10.47	7.98	-1	19	-	PDSP KiDatabase	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	-
(+)-butaclamol	746	3H-KETANSERIN	9	Bovine	Binding	pKi	=	17.00	7.77	-39	25	-	PDSP KiDatabase	361.2	0	1	2	4.84	CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc(c43)[C@@H]2C1	-
(+)-chlorpheniramine	918	None	42	Human	Binding	AC50	=	4060.40	5.39	-10	27	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274.1	5	0	2	3.82	CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1	https://dx.doi.org/10.1038/s41467-023-40064-9
(+)-chlorpheniramine	918	None	42	Human	Binding	pKi	=	5.17	8.29	-10	27	None	Drug Central	274.1	5	0	2	3.82	CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1	-
(+)-DOI	1458	None	4	Human	Binding	pKi	None	-	7.60	-25	5	Unclassified	Guide to Pharmacology	321.0	4	1	3	2.20	COc1cc(C[C@H](C)N)c(OC)cc1I	https://pubmed.ncbi.nlm.nih.gov/15322733

Showing 1 to 20 of 2,890 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)