GPCRdb

Ligand source activities (1 row/activity)

Potency
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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1324	302	None	25	Mouse	Functional	pEC50	=	10.5	10.5	-5	9	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	16154396	302	None	25	Mouse	Functional	pEC50	=	10.5	10.5	-5	9	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	16197727	302	None	25	Mouse	Functional	pEC50	=	10.5	10.5	-5	9	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	44285019	302	None	25	Mouse	Functional	pEC50	=	10.5	10.5	-5	9	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	57514683	302	None	25	Mouse	Functional	pEC50	=	10.5	10.5	-5	9	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	91898441	302	None	25	Mouse	Functional	pEC50	=	10.5	10.5	-5	9	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	10.5	10.5	-5	9	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	DB04931	302	None	25	Mouse	Functional	pEC50	=	10.5	10.5	-5	9	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	CHEMBL2371966	210161	None	0	Human	Functional	pEC50	=	10.5	10.5	616	4	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm0614275
	118722937	116236	None	0	Mouse	Functional	pEC50	=	10.4	10.4	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358545	116236	None	0	Mouse	Functional	pEC50	=	10.4	10.4	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	118722941	116240	None	0	Mouse	Functional	pEC50	=	10.4	10.4	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358549	116240	None	0	Mouse	Functional	pEC50	=	10.4	10.4	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	118722933	116233	None	0	Mouse	Functional	pEC50	=	10.3	10.3	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1038	33	13	11	1.2	CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	CHEMBL3358541	116233	None	0	Mouse	Functional	pEC50	=	10.3	10.3	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1038	33	13	11	1.2	CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	1324	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	16154396	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	16197727	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	44285019	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	57514683	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	91898441	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	DB04931	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	1324	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	16154396	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	16197727	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	44285019	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	57514683	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	91898441	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	DB04931	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	118722944	116243	None	0	Mouse	Functional	pEC50	=	10.2	10.2	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1034	17	13	13	-1.1	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358552	116243	None	0	Mouse	Functional	pEC50	=	10.2	10.2	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1034	17	13	13	-1.1	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	1324	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	16154396	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	16197727	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	44285019	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	57514683	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	91898441	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	DB04931	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	1324	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	16154396	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	16197727	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	44285019	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	57514683	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	91898441	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	DB04931	302	None	25	Mouse	Functional	pEC50	=	10.2	10.2	-5	9	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	CHEMBL414965	213164	None	0	Mouse	Functional	pEC50	=	10.1	10.1	-1	5	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	1324	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	16154396	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	16197727	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	44285019	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	57514683	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	91898441	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	DB04931	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	1324	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	16154396	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	16197727	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	44285019	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	57514683	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	91898441	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	DB04931	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	1324	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	16154396	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	16197727	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	44285019	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	57514683	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	91898441	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	DB04931	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	118722930	116231	None	0	Mouse	Functional	pEC50	=	10.1	10.1	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	CHEMBL3358539	116231	None	0	Mouse	Functional	pEC50	=	10.1	10.1	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	1324	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	16154396	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	16197727	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	44285019	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	57514683	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	91898441	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	DB04931	302	None	25	Mouse	Functional	pEC50	=	10.1	10.1	-5	9	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	CHEMBL405087	212539	None	0	Mouse	Functional	pEC50	=	10	10.0	-1	5	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	1324	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R by alphascreen cAMP assayAgonist activity at mouse MC5R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	16154396	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R by alphascreen cAMP assayAgonist activity at mouse MC5R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	16197727	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R by alphascreen cAMP assayAgonist activity at mouse MC5R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	44285019	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R by alphascreen cAMP assayAgonist activity at mouse MC5R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	57514683	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R by alphascreen cAMP assayAgonist activity at mouse MC5R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	91898441	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R by alphascreen cAMP assayAgonist activity at mouse MC5R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R by alphascreen cAMP assayAgonist activity at mouse MC5R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	DB04931	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R by alphascreen cAMP assayAgonist activity at mouse MC5R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	1324	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	16154396	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	16197727	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	44285019	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	57514683	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	91898441	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	DB04931	302	None	25	Mouse	Functional	pEC50	=	10.0	10.0	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	CHEMBL406842	212622	None	0	Mouse	Functional	pEC50	=	10.0	10.0	3	5	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		C[C@H](O)[C@@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	CHEMBL413212	213053	None	0	Mouse	Functional	pEC50	=	9.9	9.9	-6	4	Evaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptorEvaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	127036484	136443	None	0	Mouse	Functional	pEC50	=	9.9	9.9	-2	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1024	17	14	11	-1.0	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	CHEMBL3735690	136443	None	0	Mouse	Functional	pEC50	=	9.9	9.9	-2	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1024	17	14	11	-1.0	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	CHEMBL410404	212817	None	0	Mouse	Functional	pEC50	=	9.9	9.9	11	5	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	118722926	116228	None	0	Mouse	Functional	pEC50	=	9.9	9.9	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL3358535	116228	None	0	Mouse	Functional	pEC50	=	9.9	9.9	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	118722931	116232	None	0	Mouse	Functional	pEC50	=	9.9	9.9	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	CHEMBL3358540	116232	None	0	Mouse	Functional	pEC50	=	9.9	9.9	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	118722938	116237	None	0	Mouse	Functional	pEC50	=	9.9	9.9	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCc2cn(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358546	116237	None	0	Mouse	Functional	pEC50	=	9.9	9.9	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCc2cn(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	1324	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	16154396	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	16197727	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	44285019	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	57514683	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	91898441	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	DB04931	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	127036484	136443	None	0	Mouse	Functional	pEC50	=	9.9	9.9	-2	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1024	17	14	11	-1.0	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	CHEMBL3735690	136443	None	0	Mouse	Functional	pEC50	=	9.9	9.9	-2	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1024	17	14	11	-1.0	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	1324	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Inverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assayInverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00684
	16154396	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Inverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assayInverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00684
	16197727	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Inverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assayInverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00684
	44285019	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Inverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assayInverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00684
	57514683	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Inverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assayInverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00684
	91898441	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Inverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assayInverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00684
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Inverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assayInverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00684
	DB04931	302	None	25	Mouse	Functional	pEC50	=	9.9	9.9	-5	9	Inverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assayInverse agonist activity at mouse MC5R expressed in HEK293 cells incubated for 2 hrs by AlphaScreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00684
	CHEMBL411400	212881	None	0	Mouse	Functional	pEC50	=	9.9	9.9	48	5	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC1(C)C)C(N)=O	10.1021/jm030452x
	118722942	116241	None	0	Mouse	Functional	pEC50	=	9.8	9.8	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cn2cc(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358550	116241	None	0	Mouse	Functional	pEC50	=	9.8	9.8	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cn2cc(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	118722943	116242	None	0	Mouse	Functional	pEC50	=	9.8	9.8	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1034	17	13	13	-1.1	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358551	116242	None	0	Mouse	Functional	pEC50	=	9.8	9.8	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1034	17	13	13	-1.1	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	1323	2686	None	55	Mouse	Functional	pEC50	=	9.8	9.8	-5	8	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	92432	2686	None	55	Mouse	Functional	pEC50	=	9.8	9.8	-5	8	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	CHEMBL430239	2686	None	55	Mouse	Functional	pEC50	=	9.8	9.8	-5	8	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	44310104	81586	None	0	Mouse	Functional	pEC50	=	9.8	9.8	-7	4	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	1040	16	13	13	-1.5	CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CC(=O)ONCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0303608
	CHEMBL216295	81586	None	0	Mouse	Functional	pEC50	=	9.8	9.8	-7	4	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	1040	16	13	13	-1.5	CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CC(=O)ONCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0303608
	CHEMBL2371851	210137	None	0	Mouse	Functional	pEC50	=	9.8	9.8	-3	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N1C(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]1CC(=O)O	10.1021/jm0490843
	CHEMBL405335	212554	None	0	Mouse	Functional	pEC50	=	9.8	9.8	2	4	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	118722927	116229	None	0	Mouse	Functional	pEC50	=	9.7	9.7	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL3358536	116229	None	0	Mouse	Functional	pEC50	=	9.7	9.7	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	122194229	123981	None	0	Mouse	Functional	pEC50	=	9.7	9.7	-7	5	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1646	50	23	21	-4.1	CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.10.095
	CHEMBL3629347	123981	None	0	Mouse	Functional	pEC50	=	9.7	9.7	-7	5	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1646	50	23	21	-4.1	CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.10.095
	1324	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	16154396	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	16197727	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	44285019	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	57514683	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	91898441	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	DB04931	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	1323	2686	None	55	Mouse	Functional	pEC50	=	9.7	9.7	-5	8	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	92432	2686	None	55	Mouse	Functional	pEC50	=	9.7	9.7	-5	8	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	CHEMBL430239	2686	None	55	Mouse	Functional	pEC50	=	9.7	9.7	-5	8	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	1324	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	16154396	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	16197727	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	44285019	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	57514683	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	91898441	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	DB04931	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	1323	2686	None	55	Mouse	Functional	pEC50	=	9.7	9.7	-5	8	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	92432	2686	None	55	Mouse	Functional	pEC50	=	9.7	9.7	-5	8	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	CHEMBL430239	2686	None	55	Mouse	Functional	pEC50	=	9.7	9.7	-5	8	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	1324	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	16154396	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	16197727	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	44285019	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	57514683	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	91898441	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	DB04931	302	None	25	Mouse	Functional	pEC50	=	9.7	9.7	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	16132144	209277	None	36	Mouse	Functional	pEC50	=	9.7	9.7	-1	8	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.5b00053
	16133793	209277	None	36	Mouse	Functional	pEC50	=	9.7	9.7	-1	8	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.5b00053
	44273719	209277	None	36	Mouse	Functional	pEC50	=	9.7	9.7	-1	8	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.5b00053
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	9.7	9.7	-1	8	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.5b00053
	16132144	209277	None	36	Mouse	Functional	pEC50	=	9.7	9.7	-1	8	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.9b00198
	16133793	209277	None	36	Mouse	Functional	pEC50	=	9.7	9.7	-1	8	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.9b00198
	44273719	209277	None	36	Mouse	Functional	pEC50	=	9.7	9.7	-1	8	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.9b00198
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	9.7	9.7	-1	8	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.9b00198
	CHEMBL408843	212733	None	0	Human	Functional	pEC50	=	9.7	9.7	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL		None	None	None		CC(=O)N[C@@H]1CSSC[C@@H](C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm010165y
	118722932	115516	None	0	Mouse	Functional	pEC50	=	9.6	9.6	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1038	33	13	11	1.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL3352878	115516	None	0	Mouse	Functional	pEC50	=	9.6	9.6	1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1038	33	13	11	1.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL2371969	210164	None	0	Human	Functional	pEC50	=	9.6	9.6	1000	3	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](C(C)C)NC1=O	10.1021/jm0614275
	1324	302	None	25	Human	Functional	pEC50	=	9.6	9.6	-13	9	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	16154396	302	None	25	Human	Functional	pEC50	=	9.6	9.6	-13	9	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	16197727	302	None	25	Human	Functional	pEC50	=	9.6	9.6	-13	9	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	44285019	302	None	25	Human	Functional	pEC50	=	9.6	9.6	-13	9	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	57514683	302	None	25	Human	Functional	pEC50	=	9.6	9.6	-13	9	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	91898441	302	None	25	Human	Functional	pEC50	=	9.6	9.6	-13	9	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	CHEMBL441738	302	None	25	Human	Functional	pEC50	=	9.6	9.6	-13	9	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	DB04931	302	None	25	Human	Functional	pEC50	=	9.6	9.6	-13	9	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	1324	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	16154396	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	16197727	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	44285019	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	57514683	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	91898441	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	DB04931	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	1324	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	16154396	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	16197727	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	44285019	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	57514683	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	91898441	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	DB04931	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	122194229	123981	None	0	Mouse	Functional	pEC50	=	9.6	9.6	-7	5	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL	1646	50	23	21	-4.1	CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	CHEMBL3629347	123981	None	0	Mouse	Functional	pEC50	=	9.6	9.6	-7	5	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL	1646	50	23	21	-4.1	CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	1324	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	16154396	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	16197727	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	44285019	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	57514683	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	91898441	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	DB04931	302	None	25	Mouse	Functional	pEC50	=	9.6	9.6	-5	9	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	CHEMBL2371971	210166	None	0	Human	Functional	pEC50	=	9.5	9.5	1288	2	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](c2ccccc2)NC1=O	10.1021/jm0614275
	CHEMBL501592	214139	None	0	Human	Functional	pEC50	=	9.5	9.5	37	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	134463477	159250	None	0	Mouse	Functional	pEC50	=	9.5	9.5	3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	977	11	12	11	-1.9	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4099127	159250	None	0	Mouse	Functional	pEC50	=	9.5	9.5	3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	977	11	12	11	-1.9	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	1324	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	16154396	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	16197727	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	44285019	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	57514683	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	91898441	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	DB04931	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	1324	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	16154396	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	16197727	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	44285019	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	57514683	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	91898441	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	DB04931	302	None	25	Mouse	Functional	pEC50	=	9.5	9.5	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	45487403	197433	None	0	Mouse	Functional	pEC50	=	9.5	9.5	-33	5	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	788	22	9	7	2.4	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CC1=CN=CC1)NC(=O)CCCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569693	197433	None	0	Mouse	Functional	pEC50	=	9.5	9.5	-33	5	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	788	22	9	7	2.4	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CC1=CN=CC1)NC(=O)CCCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2009.07.025
	118722936	116235	None	0	Mouse	Functional	pEC50	=	9.5	9.5	-3	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358544	116235	None	0	Mouse	Functional	pEC50	=	9.5	9.5	-3	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL2371962	210157	None	0	Human	Functional	pEC50	=	9.4	9.4	8	4	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0614275
	CHEMBL267794	210731	None	0	Mouse	Functional	pEC50	=	9.4	9.4	-11	4	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	1324	302	None	25	Human	Functional	pEC50	=	9.4	9.4	-13	9	Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	16154396	302	None	25	Human	Functional	pEC50	=	9.4	9.4	-13	9	Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	16197727	302	None	25	Human	Functional	pEC50	=	9.4	9.4	-13	9	Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	44285019	302	None	25	Human	Functional	pEC50	=	9.4	9.4	-13	9	Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	57514683	302	None	25	Human	Functional	pEC50	=	9.4	9.4	-13	9	Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	91898441	302	None	25	Human	Functional	pEC50	=	9.4	9.4	-13	9	Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	CHEMBL441738	302	None	25	Human	Functional	pEC50	=	9.4	9.4	-13	9	Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	DB04931	302	None	25	Human	Functional	pEC50	=	9.4	9.4	-13	9	Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	16132144	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2003.08.078
	16133793	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2003.08.078
	44273719	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2003.08.078
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2003.08.078
	1324	302	None	25	Mouse	Functional	pEC50	=	9.4	9.4	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	16154396	302	None	25	Mouse	Functional	pEC50	=	9.4	9.4	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	16197727	302	None	25	Mouse	Functional	pEC50	=	9.4	9.4	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	44285019	302	None	25	Mouse	Functional	pEC50	=	9.4	9.4	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	57514683	302	None	25	Mouse	Functional	pEC50	=	9.4	9.4	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	91898441	302	None	25	Mouse	Functional	pEC50	=	9.4	9.4	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	9.4	9.4	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	DB04931	302	None	25	Mouse	Functional	pEC50	=	9.4	9.4	-5	9	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	16132144	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	16133793	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	44273719	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	CHEMBL307457	210979	None	0	Mouse	Functional	pEC50	=	9.4	9.4	10	4	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	CHEMBL266417	210681	None	0	Mouse	Functional	pEC50	=	9.4	9.4	-12	6	Evaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptorEvaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	16132144	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010524p
	16133793	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010524p
	44273719	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010524p
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010524p
	16132144	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303608
	16133793	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303608
	44273719	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303608
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-1	8	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303608
	CHEMBL2371967	210162	None	0	Human	Functional	pEC50	=	9.4	9.4	275	4	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2C1=O	10.1021/jm0614275
	134466953	156656	None	0	Mouse	Functional	pEC50	=	9.4	9.4	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1153	14	13	12	-1.3	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4069451	156656	None	0	Mouse	Functional	pEC50	=	9.4	9.4	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1153	14	13	12	-1.3	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	90643803	111741	None	0	Mouse	Functional	pEC50	=	9.4	9.4	1	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	898	18	9	7	0.4	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287323	111741	None	0	Mouse	Functional	pEC50	=	9.4	9.4	1	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	898	18	9	7	0.4	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	CHEMBL386081	212373	None	0	Mouse	Functional	pEC50	=	9.3	9.3	-25	4	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm010061n
	CHEMBL429236	213514	None	0	Mouse	Functional	pEC50	=	9.3	9.3	-21	4	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	10886436	119155	None	0	Mouse	Functional	pEC50	=	9.3	9.3	1	5	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	588	8	2	6	4.6	O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1021/acs.jmedchem.0c02041
	CHEMBL342954	119155	None	0	Mouse	Functional	pEC50	=	9.3	9.3	1	5	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	588	8	2	6	4.6	O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1021/acs.jmedchem.0c02041
	16132144	209277	None	36	Mouse	Functional	pEC50	=	9.3	9.3	-1	8	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	16133793	209277	None	36	Mouse	Functional	pEC50	=	9.3	9.3	-1	8	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	44273719	209277	None	36	Mouse	Functional	pEC50	=	9.3	9.3	-1	8	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	9.3	9.3	-1	8	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	CHEMBL410763	212836	None	0	Mouse	Functional	pEC50	=	9.3	9.3	-14	4	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	CHEMBL2369484	209625	None	0	Mouse	Functional	pEC50	=	9.3	9.3	-2	4	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NN[C@H]2Cc3ccc(O)cc3NC2=O)CC(=O)N[C@H](C(=O)NN[C@@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	CHEMBL411378	212879	None	0	Mouse	Functional	pEC50	=	9.3	9.3	16	5	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		Cc1nc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CSSC[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc3ccccc3)NC2=O)c[nH]1	10.1021/jm030452x
	44310344	97327	None	0	Mouse	Functional	pEC50	=	9.3	9.3	-3	4	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	4414	53	53	68	-9.9	CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NN(Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4	10.1021/jm0303608
	77231883	97327	None	0	Mouse	Functional	pEC50	=	9.3	9.3	-3	4	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	4414	53	53	68	-9.9	CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NN(Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4	10.1021/jm0303608
	CHEMBL269274	97327	None	0	Mouse	Functional	pEC50	=	9.3	9.3	-3	4	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	4414	53	53	68	-9.9	CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NN(Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4	10.1021/jm0303608
	10078903	68017	None	0	Mouse	Functional	pEC50	=	9.2	9.2	-1	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	769	24	9	7	1.8	CCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL191303	68017	None	0	Mouse	Functional	pEC50	=	9.2	9.2	-1	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	769	24	9	7	1.8	CCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	1324	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	16154396	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	16197727	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	44285019	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	57514683	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	91898441	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	CHEMBL441738	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	DB04931	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	1324	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	16154396	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	16197727	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	44285019	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	57514683	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	91898441	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	CHEMBL441738	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	DB04931	302	None	25	Human	Functional	pEC50	=	9.2	9.2	-13	9	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	16132144	209277	None	36	Mouse	Functional	pEC50	=	9.2	9.2	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.5b01894
	16133793	209277	None	36	Mouse	Functional	pEC50	=	9.2	9.2	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.5b01894
	44273719	209277	None	36	Mouse	Functional	pEC50	=	9.2	9.2	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.5b01894
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	9.2	9.2	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.5b01894
	CHEMBL264536	210625	None	5	Mouse	Functional	pEC50	=	9.2	9.2	-13	4	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm010061n
	90643806	111744	None	0	Mouse	Functional	pEC50	=	9.2	9.2	6	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	728	14	5	8	1.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287326	111744	None	0	Mouse	Functional	pEC50	=	9.2	9.2	6	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	728	14	5	8	1.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	CHEMBL428801	213470	None	0	Mouse	Functional	pEC50	=	9.2	9.2	-12	5	Evaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptorEvaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	101670969	168894	None	23	Mouse	Functional	pEC50	=	9.2	9.2	-1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	16131138	168894	None	23	Mouse	Functional	pEC50	=	9.2	9.2	-1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	44349184	168894	None	23	Mouse	Functional	pEC50	=	9.2	9.2	-1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	53310908	168894	None	23	Mouse	Functional	pEC50	=	9.2	9.2	-1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	91898438	168894	None	23	Mouse	Functional	pEC50	=	9.2	9.2	-1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL438402	168894	None	23	Mouse	Functional	pEC50	=	9.2	9.2	-1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	16132144	209277	None	36	Mouse	Functional	pEC50	=	9.2	9.2	-1	8	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0490843
	16133793	209277	None	36	Mouse	Functional	pEC50	=	9.2	9.2	-1	8	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0490843
	44273719	209277	None	36	Mouse	Functional	pEC50	=	9.2	9.2	-1	8	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0490843
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	9.2	9.2	-1	8	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0490843
	122184910	122553	None	0	Human	Functional	pEC50	=	9.1	9.1	2	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601428	122553	None	0	Human	Functional	pEC50	=	9.1	9.1	2	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	16132144	209277	None	36	Mouse	Functional	pEC50	=	9.1	9.1	-1	8	Evaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptorEvaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm00018a005
	16133793	209277	None	36	Mouse	Functional	pEC50	=	9.1	9.1	-1	8	Evaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptorEvaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm00018a005
	44273719	209277	None	36	Mouse	Functional	pEC50	=	9.1	9.1	-1	8	Evaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptorEvaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm00018a005
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	9.1	9.1	-1	8	Evaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptorEvaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm00018a005
	90643802	111740	None	0	Mouse	Functional	pEC50	=	9.1	9.1	2	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	820	14	5	8	1.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287322	111740	None	0	Mouse	Functional	pEC50	=	9.1	9.1	2	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	820	14	5	8	1.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	11158573	71117	None	0	Mouse	Functional	pEC50	=	9.1	9.1	-2	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	783	25	9	7	2.1	CCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL195439	71117	None	0	Mouse	Functional	pEC50	=	9.1	9.1	-2	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	783	25	9	7	2.1	CCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	137637283	155978	None	0	Human	Functional	pEC50	=	9.0	9.0	-2	3	Agonist activity at human MC5R expressed in CHO cells assessed as increase in IBMX-induced cAMP accumulation after 40 minsAgonist activity at human MC5R expressed in CHO cells assessed as increase in IBMX-induced cAMP accumulation after 40 mins	ChEMBL	984	15	12	10	-0.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4061566	155978	None	0	Human	Functional	pEC50	=	9.0	9.0	-2	3	Agonist activity at human MC5R expressed in CHO cells assessed as increase in IBMX-induced cAMP accumulation after 40 minsAgonist activity at human MC5R expressed in CHO cells assessed as increase in IBMX-induced cAMP accumulation after 40 mins	ChEMBL	984	15	12	10	-0.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL2371968	210163	None	0	Human	Functional	pEC50	=	9	9.0	-	1	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2CC3CCCCC3N2C1=O	10.1021/jm0614275
	CHEMBL2371970	210165	None	0	Human	Functional	pEC50	=	9	9.0	-	1	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](C2CCCCC2)NC1=O	10.1021/jm0614275
	90643808	111745	None	0	Mouse	Functional	pEC50	=	9	9.0	7	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	747	16	7	8	1.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287328	111745	None	0	Mouse	Functional	pEC50	=	9	9.0	7	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	747	16	7	8	1.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	1324	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16154396	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16197727	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	44285019	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	57514683	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	91898441	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL441738	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	DB04931	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	1324	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	16154396	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	16197727	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	44285019	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	57514683	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	91898441	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	CHEMBL441738	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	DB04931	302	None	25	Human	Functional	pEC50	=	9	9.0	-13	9	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	1324	302	None	25	Human	Functional	pEC50	=	9.0	9.0	-13	9	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	16154396	302	None	25	Human	Functional	pEC50	=	9.0	9.0	-13	9	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	16197727	302	None	25	Human	Functional	pEC50	=	9.0	9.0	-13	9	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	44285019	302	None	25	Human	Functional	pEC50	=	9.0	9.0	-13	9	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	57514683	302	None	25	Human	Functional	pEC50	=	9.0	9.0	-13	9	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	91898441	302	None	25	Human	Functional	pEC50	=	9.0	9.0	-13	9	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	CHEMBL441738	302	None	25	Human	Functional	pEC50	=	9.0	9.0	-13	9	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	DB04931	302	None	25	Human	Functional	pEC50	=	9.0	9.0	-13	9	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	122184635	122432	None	0	Human	Functional	pEC50	=	9.0	9.0	2	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600916	122432	None	0	Human	Functional	pEC50	=	9.0	9.0	2	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	90643804	111742	None	0	Mouse	Functional	pEC50	=	9.0	9.0	2	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	839	16	7	8	1.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287324	111742	None	0	Mouse	Functional	pEC50	=	9.0	9.0	2	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	839	16	7	8	1.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	16132144	209277	None	36	Mouse	Functional	pEC50	=	9.0	9.0	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0492756
	16133793	209277	None	36	Mouse	Functional	pEC50	=	9.0	9.0	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0492756
	44273719	209277	None	36	Mouse	Functional	pEC50	=	9.0	9.0	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0492756
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	9.0	9.0	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0492756
	CHEMBL2096742	209204	None	0	Human	Functional	pEC50	=	8.9	8.9	1	6	Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm801300c
	CHEMBL428615	213458	None	0	Mouse	Functional	pEC50	=	8.9	8.9	-70	5	Evaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptorEvaluated for agonist activity at cloned mammalian mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	155553683	174181	None	0	Mouse	Functional	pEC50	=	8.9	8.9	-4	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	746	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4547556	174181	None	0	Mouse	Functional	pEC50	=	8.9	8.9	-4	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	746	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL1688107	208832	None	0	Mouse	Functional	pEC50	=	8.8	8.8	-8	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	CHEMBL491870	214075	None	0	Mouse	Functional	pEC50	=	8.8	8.8	-3	5	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	1323	2686	None	55	Human	Functional	pEC50	=	8.8	8.8	-181	8	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	92432	2686	None	55	Human	Functional	pEC50	=	8.8	8.8	-181	8	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.8	8.8	-181	8	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	CHEMBL2371963	210158	None	0	Human	Functional	pEC50	=	8.8	8.8	295	4	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm0614275
	CHEMBL500743	214122	None	0	Human	Functional	pEC50	=	8.8	8.8	1	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	CHEMBL322610	211232	None	0	Mouse	Functional	pEC50	=	8.8	8.8	2	4	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	155555217	174335	None	0	Mouse	Functional	pEC50	=	8.8	8.8	6	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	775	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4550976	174335	None	0	Mouse	Functional	pEC50	=	8.8	8.8	6	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	775	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	1323	2686	None	55	Human	Functional	pEC50	=	8.8	8.8	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	92432	2686	None	55	Human	Functional	pEC50	=	8.8	8.8	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.8	8.8	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	118722939	116238	None	0	Mouse	Functional	pEC50	=	8.8	8.8	-3	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358547	116238	None	0	Mouse	Functional	pEC50	=	8.8	8.8	-3	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL2370966	209967	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	118722940	116239	None	0	Mouse	Functional	pEC50	=	8.7	8.7	-2	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358548	116239	None	0	Mouse	Functional	pEC50	=	8.7	8.7	-2	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358537	211566	None	0	Mouse	Functional	pEC50	=	8.7	8.7	-7	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C#CC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	145976863	163756	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	879	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4205548	163756	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	879	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL503229	214161	None	0	Human	Functional	pEC50	=	8.7	8.7	-2	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm801300c
	CHEMBL443071	213918	None	0	Human	Functional	pEC50	=	8.7	8.7	-2	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	118722935	116234	None	0	Mouse	Functional	pEC50	=	8.7	8.7	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358543	116234	None	0	Mouse	Functional	pEC50	=	8.7	8.7	-1	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	1324	302	None	25	Mouse	Functional	pEC50	=	8.7	8.7	-5	9	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	16154396	302	None	25	Mouse	Functional	pEC50	=	8.7	8.7	-5	9	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	16197727	302	None	25	Mouse	Functional	pEC50	=	8.7	8.7	-5	9	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	44285019	302	None	25	Mouse	Functional	pEC50	=	8.7	8.7	-5	9	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	57514683	302	None	25	Mouse	Functional	pEC50	=	8.7	8.7	-5	9	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	91898441	302	None	25	Mouse	Functional	pEC50	=	8.7	8.7	-5	9	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	8.7	8.7	-5	9	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	DB04931	302	None	25	Mouse	Functional	pEC50	=	8.7	8.7	-5	9	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	11787684	70272	None	0	Mouse	Functional	pEC50	=	8	8.0	-3	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	811	27	9	7	2.9	CCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL194217	70272	None	0	Mouse	Functional	pEC50	=	8	8.0	-3	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	811	27	9	7	2.9	CCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL3752534	212214	None	1	Human	Functional	pEC50	=	8	8.0	-25	4	Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.5b01285
	10483153	60809	None	0	Human	Functional	pEC50	=	6	6.0	-87	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	571	6	3	4	4.2	C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1761873	60809	None	0	Human	Functional	pEC50	=	6	6.0	-87	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	571	6	3	4	4.2	C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	49862377	15039	None	0	Human	Functional	pEC50	=	6	6.0	-40	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	654	9	0	6	6.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cnn(C(C)C)c1	10.1016/j.bmcl.2010.06.038
	CHEMBL1209320	15039	None	0	Human	Functional	pEC50	=	6	6.0	-40	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	654	9	0	6	6.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cnn(C(C)C)c1	10.1016/j.bmcl.2010.06.038
	137632948	156580	None	0	Mouse	Functional	pEC50	=	6	6.0	-4	2	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4068643	156580	None	0	Mouse	Functional	pEC50	=	6	6.0	-4	2	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	44401319	12280	None	0	Human	Functional	pEC50	=	6	6.0	-19	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	599	7	4	5	3.9	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C(C)(C)C)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL1184826	12280	None	0	Human	Functional	pEC50	=	6	6.0	-19	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	599	7	4	5	3.9	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C(C)(C)C)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL2028959	12280	None	0	Human	Functional	pEC50	=	6	6.0	-19	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	599	7	4	5	3.9	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C(C)(C)C)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL407213	212646	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL		None	None	None		CC(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm010165y
	155555947	174510	None	0	Mouse	Functional	pEC50	=	5	5.0	-77	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	592	14	7	6	-0.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4555150	174510	None	0	Mouse	Functional	pEC50	=	5	5.0	-77	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	592	14	7	6	-0.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	11017471	31915	None	0	Human	Functional	pEC50	=	6	6.0	-295	2	Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulation	ChEMBL	603	8	2	7	4.0	Cn1nnc(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)n1	10.1021/jm025539h
	CHEMBL140738	31915	None	0	Human	Functional	pEC50	=	6	6.0	-295	2	Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulation	ChEMBL	603	8	2	7	4.0	Cn1nnc(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)n1	10.1021/jm025539h
	44448629	167461	None	0	Human	Functional	pEC50	=	7.0	7.0	-91	4	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL429854	167461	None	0	Human	Functional	pEC50	=	7.0	7.0	-91	4	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL50056	214117	None	2	Mouse	Functional	pEC50	=	7.0	7.0	-8	7	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	CHEMBL50056	214117	None	2	Mouse	Functional	pEC50	=	7.0	7.0	-8	7	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	164621851	185859	None	0	Mouse	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	529	13	3	3	5.8	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CCCC(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL4867949	185859	None	0	Mouse	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	529	13	3	3	5.8	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CCCC(C)C	10.1021/acs.jmedchem.0c02041
	45487296	197323	None	0	Mouse	Functional	pEC50	=	5.0	5.0	-8	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	635	18	8	7	0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)c1ccc(F)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL568836	197323	None	0	Mouse	Functional	pEC50	=	5.0	5.0	-8	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	635	18	8	7	0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)c1ccc(F)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	45487416	197015	None	0	Mouse	Functional	pEC50	=	5.0	5.0	-9	2	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	605	17	9	7	-0.3	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1ccc(O)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL567039	197015	None	0	Mouse	Functional	pEC50	=	5.0	5.0	-9	2	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	605	17	9	7	-0.3	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1ccc(O)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL3600833	211812	None	0	Human	Functional	pEC50	=	6.0	6.0	-9	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	137633806	156479	None	0	Human	Functional	pEC50	=	7.0	7.0	-38	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1031	14	14	13	-2.0	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O	10.1021/acs.jmedchem.7b00353
	CHEMBL4067491	156479	None	0	Human	Functional	pEC50	=	7.0	7.0	-38	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1031	14	14	13	-2.0	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O	10.1021/acs.jmedchem.7b00353
	CHEMBL264190	210606	None	1	Mouse	Functional	pEC50	=	8.0	8.0	2	8	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	155563055	175293	None	0	Mouse	Functional	pEC50	=	8.0	8.0	-2	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	686	18	9	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4573041	175293	None	0	Mouse	Functional	pEC50	=	8.0	8.0	-2	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	686	18	9	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL319871	211222	None	0	Mouse	Functional	pEC50	=	7.9	7.9	2	4	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	CHEMBL2323791	209515	None	0	Mouse	Functional	pEC50	=	6.0	6.0	4	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	44441637	94047	None	0	Human	Functional	pEC50	=	6.0	6.0	-4	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	506	7	2	4	4.3	CC(C)C1(CC#N)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL248892	94047	None	0	Human	Functional	pEC50	=	6.0	6.0	-4	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	506	7	2	4	4.3	CC(C)C1(CC#N)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	44441685	94130	None	0	Human	Functional	pEC50	=	6.0	6.0	-4	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	585	7	3	5	3.5	CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCC(C)(C)CC3)CC2)C1	10.1016/j.bmcl.2006.11.084
	CHEMBL249322	94130	None	0	Human	Functional	pEC50	=	6.0	6.0	-4	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	585	7	3	5	3.5	CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCC(C)(C)CC3)CC2)C1	10.1016/j.bmcl.2006.11.084
	CHEMBL319922	211223	None	0	Mouse	Functional	pEC50	=	5.0	5.0	1	2	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	CHEMBL2448525	210497	None	0	Mouse	Functional	pEC50	=	4.9	4.9	-177	4	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	CHEMBL102391	208453	None	0	Mouse	Functional	pEC50	=	4.9	4.9	2	2	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	45487404	197434	None	0	Mouse	Functional	pEC50	=	4.9	4.9	-2344	5	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	603	18	8	6	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569694	197434	None	0	Mouse	Functional	pEC50	=	4.9	4.9	-2344	5	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	603	18	8	6	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	44408388	140321	None	0	Human	Functional	pEC50	=	5.9	5.9	-45	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	646	8	2	5	5.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CCC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL380635	140321	None	0	Human	Functional	pEC50	=	5.9	5.9	-45	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	646	8	2	5	5.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CCC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	155547842	173694	None	0	Mouse	Functional	pEC50	=	5.9	5.9	-50	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	741	17	10	7	-1.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4535510	173694	None	0	Mouse	Functional	pEC50	=	5.9	5.9	-50	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	741	17	10	7	-1.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	44448479	155369	None	0	Human	Functional	pEC50	=	5.9	5.9	-9	3	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	573	6	1	3	7.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL403420	155369	None	0	Human	Functional	pEC50	=	5.9	5.9	-9	3	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	573	6	1	3	7.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2008.04.049
	44310242	156307	None	0	Mouse	Functional	pEC50	=	6.9	6.9	16	3	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	1421	24	20	20	-4.6	C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	91932912	156307	None	0	Mouse	Functional	pEC50	=	6.9	6.9	16	3	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	1421	24	20	20	-4.6	C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	CHEMBL406550	156307	None	0	Mouse	Functional	pEC50	=	6.9	6.9	16	3	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	1421	24	20	20	-4.6	C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	CHEMBL2323529	209508	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-1	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	168285801	191479	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5193501	191479	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	164623712	185655	None	0	Mouse	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	537	13	3	3	5.3	CC(C)CCCN1C(=N)N([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C[C@H]1C(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL4864765	185655	None	0	Mouse	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	537	13	3	3	5.3	CC(C)CCCN1C(=N)N([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C[C@H]1C(C)C	10.1021/acs.jmedchem.0c02041
	11061068	31290	None	0	Human	Functional	pEC50	=	6.9	6.9	-295	3	Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulation	ChEMBL	603	8	2	7	4.0	Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm025539h
	CHEMBL140154	31290	None	0	Human	Functional	pEC50	=	6.9	6.9	-295	3	Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulation	ChEMBL	603	8	2	7	4.0	Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm025539h
	45487407	196966	None	0	Mouse	Functional	pEC50	=	4.9	4.9	-7	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	617	17	8	7	0.1	COc1ccccc1/C=C/C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL566545	196966	None	0	Mouse	Functional	pEC50	=	4.9	4.9	-7	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	617	17	8	7	0.1	COc1ccccc1/C=C/C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2009.07.025
	155561743	175770	None	0	Mouse	Functional	pEC50	=	7.9	7.9	3	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	718	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4583714	175770	None	0	Mouse	Functional	pEC50	=	7.9	7.9	3	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	718	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	155566298	175791	None	0	Mouse	Functional	pEC50	=	7.9	7.9	3	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	683	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4584189	175791	None	0	Mouse	Functional	pEC50	=	7.9	7.9	3	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	683	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	164624151	185796	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL	958	18	8	6	2.8	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4866885	185796	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL	958	18	8	6	2.8	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164626157	186390	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4875776	186390	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	137653704	158631	None	0	Mouse	Functional	pEC50	=	5.9	5.9	-3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	838	18	8	7	2.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4092424	158631	None	0	Mouse	Functional	pEC50	=	5.9	5.9	-3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	838	18	8	7	2.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	155550338	174306	None	0	Mouse	Functional	pEC50	=	5.9	5.9	-18	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	649	17	10	7	-1.6	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4550246	174306	None	0	Mouse	Functional	pEC50	=	5.9	5.9	-18	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	649	17	10	7	-1.6	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL2369131	209591	None	0	Mouse	Functional	pEC50	=	4.9	4.9	-3	4	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	137638778	156756	None	0	Human	Functional	pEC50	=	6.9	6.9	-81	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1053	18	14	15	-2.4	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4070639	156756	None	0	Human	Functional	pEC50	=	6.9	6.9	-81	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1053	18	14	15	-2.4	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	145966490	164360	None	0	Human	Functional	pEC50	=	7.9	7.9	-3	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	839	11	12	9	-1.2	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4212762	164360	None	0	Human	Functional	pEC50	=	7.9	7.9	-3	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	839	11	12	9	-1.2	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	145975465	163947	None	0	Human	Functional	pEC50	=	6.9	6.9	-23	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	825	11	12	9	-1.6	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4207725	163947	None	0	Human	Functional	pEC50	=	6.9	6.9	-23	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	825	11	12	9	-1.6	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	164623811	185898	None	0	Mouse	Functional	pEC50	=	6.9	6.9	1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	614	11	4	4	6.2	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4868636	185898	None	0	Mouse	Functional	pEC50	=	6.9	6.9	1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	614	11	4	4	6.2	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	155538472	173249	None	0	Mouse	Functional	pEC50	=	6.9	6.9	2	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	664	14	6	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4524668	173249	None	0	Mouse	Functional	pEC50	=	6.9	6.9	2	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	664	14	6	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL427629	213355	None	0	Human	Functional	pEC50	=	6.9	6.9	1	3	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	54584302	60810	None	0	Human	Functional	pEC50	=	5.9	5.9	-53	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	571	6	3	4	4.2	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1761874	60810	None	0	Human	Functional	pEC50	=	5.9	5.9	-53	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	571	6	3	4	4.2	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@H](C)N1	10.1016/j.bmcl.2011.02.090
	44401315	12279	None	0	Human	Functional	pEC50	=	5.9	5.9	-48	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	4	5	3.5	CC(C)[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	CHEMBL1184825	12279	None	0	Human	Functional	pEC50	=	5.9	5.9	-48	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	4	5	3.5	CC(C)[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	CHEMBL2028957	12279	None	0	Human	Functional	pEC50	=	5.9	5.9	-48	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	4	5	3.5	CC(C)[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	90661465	77160	None	0	Human	Functional	pEC50	=	5.9	5.9	-46	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	693	9	5	6	4.0	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C3CC3)CN2)CC1.CC(F)(F)C(=O)O	10.1016/j.bmcl.2005.02.068
	CHEMBL2028958	77160	None	0	Human	Functional	pEC50	=	5.9	5.9	-46	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	693	9	5	6	4.0	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C3CC3)CN2)CC1.CC(F)(F)C(=O)O	10.1016/j.bmcl.2005.02.068
	CHEMBL2078649	77160	None	0	Human	Functional	pEC50	=	5.9	5.9	-46	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	693	9	5	6	4.0	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C3CC3)CN2)CC1.CC(F)(F)C(=O)O	10.1016/j.bmcl.2005.02.068
	CHEMBL2304247	209482	None	0	Mouse	Functional	pEC50	=	5.9	5.9	-229	4	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	CHEMBL589515	215798	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-2	4	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmc.2009.12.010
	46885368	7954	None	0	Human	Functional	pEC50	=	5.8	5.8	-13	3	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	470	6	1	3	4.8	CCCCN1C[C@H](c2ccc(F)cc2F)[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)C1	10.1021/jm9017866
	CHEMBL1090484	7954	None	0	Human	Functional	pEC50	=	5.8	5.8	-13	3	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	470	6	1	3	4.8	CCCCN1C[C@H](c2ccc(F)cc2F)[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)C1	10.1021/jm9017866
	44305885	203086	None	0	Mouse	Functional	pEC50	=	4.8	4.8	1	2	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	474	13	4	4	3.5	NCCCCNC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	CHEMBL63867	203086	None	0	Mouse	Functional	pEC50	=	4.8	4.8	1	2	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	474	13	4	4	3.5	NCCCCNC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	122184911	122554	None	0	Human	Functional	pEC50	=	5.8	5.8	-8	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601429	122554	None	0	Human	Functional	pEC50	=	5.8	5.8	-8	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	16132144	209277	None	36	Mouse	Functional	pEC50	=	5.8	5.8	-1	8	Compound was evaluated for its agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsCompound was evaluated for its agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00318-4
	16133793	209277	None	36	Mouse	Functional	pEC50	=	5.8	5.8	-1	8	Compound was evaluated for its agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsCompound was evaluated for its agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00318-4
	44273719	209277	None	36	Mouse	Functional	pEC50	=	5.8	5.8	-1	8	Compound was evaluated for its agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsCompound was evaluated for its agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00318-4
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	5.8	5.8	-1	8	Compound was evaluated for its agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsCompound was evaluated for its agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00318-4
	164610489	184553	None	0	Mouse	Functional	pEC50	=	6.8	6.8	1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	600	10	4	4	5.8	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4848322	184553	None	0	Mouse	Functional	pEC50	=	6.8	6.8	1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	600	10	4	4	5.8	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL228194	209451	None	0	Human	Functional	pEC50	=	5.8	5.8	-12	2	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	46885863	8470	None	0	Human	Functional	pEC50	=	4.8	4.8	-41	2	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	446	3	1	3	3.8	C[C@H]1CN(C(=O)[C@@H]2CN(C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1	10.1021/jm9017866
	CHEMBL1093858	8470	None	0	Human	Functional	pEC50	=	4.8	4.8	-41	2	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	446	3	1	3	3.8	C[C@H]1CN(C(=O)[C@@H]2CN(C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1	10.1021/jm9017866
	CHEMBL3601431	211825	None	0	Human	Functional	pEC50	=	5.8	5.8	1	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	122184575	122425	None	0	Human	Functional	pEC50	=	5.8	5.8	-2	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600836	122425	None	0	Human	Functional	pEC50	=	5.8	5.8	-2	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	51350911	58802	None	0	Mouse	Functional	pEC50	=	5.8	5.8	-2	3	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	53322399	58802	None	0	Mouse	Functional	pEC50	=	5.8	5.8	-2	3	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	91932357	58802	None	0	Mouse	Functional	pEC50	=	5.8	5.8	-2	3	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL1688109	58802	None	0	Mouse	Functional	pEC50	=	5.8	5.8	-2	3	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL602651	215816	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-1	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)Cc1ccccc1	10.1016/j.bmc.2009.12.010
	162671821	182901	None	0	Mouse	Functional	pEC50	=	7.8	7.8	3	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	725	17	8	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4792291	182901	None	0	Mouse	Functional	pEC50	=	7.8	7.8	3	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	725	17	8	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	137648053	157537	None	0	Mouse	Functional	pEC50	=	7.8	7.8	3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	934	12	11	10	-1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4080169	157537	None	0	Mouse	Functional	pEC50	=	7.8	7.8	3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	934	12	11	10	-1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL343094	211695	None	0	Mouse	Functional	pEC50	=	6.8	6.8	1	4	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2003.08.078
	16725559	94987	None	0	Human	Functional	pEC50	=	5.8	5.8	-1230	4	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	591	6	1	3	7.5	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL254757	94987	None	0	Human	Functional	pEC50	=	5.8	5.8	-1230	4	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	591	6	1	3	7.5	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2008.04.049
	164613912	184759	None	0	Mouse	Functional	pEC50	=	5.8	5.8	6	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	523	12	3	3	4.9	CC(C)CCCN1C(=N)N([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C[C@H]1C(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL4851040	184759	None	0	Mouse	Functional	pEC50	=	5.8	5.8	6	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	523	12	3	3	4.9	CC(C)CCCN1C(=N)N([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C[C@H]1C(C)C	10.1021/acs.jmedchem.0c02041
	137640475	157085	None	0	Mouse	Functional	pEC50	=	4.8	4.8	-36	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	870	16	7	6	2.9	CC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4074368	157085	None	0	Mouse	Functional	pEC50	=	4.8	4.8	-36	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	870	16	7	6	2.9	CC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	46232220	201052	None	0	Mouse	Functional	pEC50	=	5.8	5.8	-4	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	835	12	9	8	-0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL602652	201052	None	0	Mouse	Functional	pEC50	=	5.8	5.8	-4	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	835	12	9	8	-0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	45487295	197372	None	0	Mouse	Functional	pEC50	=	4.8	4.8	-9	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	617	18	8	7	0.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569221	197372	None	0	Mouse	Functional	pEC50	=	4.8	4.8	-9	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	617	18	8	7	0.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	44448590	95597	None	0	Human	Functional	pEC50	=	6.8	6.8	-25	3	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	571	7	1	4	6.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(OC)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL257759	95597	None	0	Human	Functional	pEC50	=	6.8	6.8	-25	3	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	571	7	1	4	6.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(OC)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL432895	213633	None	4	Mouse	Functional	pEC50	=	5.8	5.8	1	4	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	CHEMBL3601426	211824	None	0	Human	Functional	pEC50	=	5.8	5.8	-17	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600832	211811	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL2371965	210160	None	0	Human	Functional	pEC50	=	7.8	7.8	331	4	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2CC3CCCCC3N2C1=O	10.1021/jm0614275
	132180597	156169	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-23	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	784	15	8	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4063911	156169	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-23	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	784	15	8	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	16132144	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.02.068
	16133793	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.02.068
	44273719	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.02.068
	CHEMBL214332	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.02.068
	16132144	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2004.10.020
	16133793	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2004.10.020
	44273719	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2004.10.020
	CHEMBL214332	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2004.10.020
	16132144	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	16133793	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	44273719	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	CHEMBL214332	209277	None	36	Human	Functional	pEC50	=	7.8	7.8	-81	8	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	CHEMBL451423	213966	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	145964017	164039	None	0	Human	Functional	pEC50	=	6.8	6.8	-10	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	915	11	12	9	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4208874	164039	None	0	Human	Functional	pEC50	=	6.8	6.8	-10	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	915	11	12	9	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	1324	302	None	25	Mouse	Functional	pEC50	=	6.8	6.8	-5	9	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	16154396	302	None	25	Mouse	Functional	pEC50	=	6.8	6.8	-5	9	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	16197727	302	None	25	Mouse	Functional	pEC50	=	6.8	6.8	-5	9	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	44285019	302	None	25	Mouse	Functional	pEC50	=	6.8	6.8	-5	9	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	57514683	302	None	25	Mouse	Functional	pEC50	=	6.8	6.8	-5	9	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	91898441	302	None	25	Mouse	Functional	pEC50	=	6.8	6.8	-5	9	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	6.8	6.8	-5	9	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	DB04931	302	None	25	Mouse	Functional	pEC50	=	6.8	6.8	-5	9	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	10146211	64327	None	0	Human	Functional	pEC50	=	6.8	6.8	-61	3	Effective concentration determined against melanocortin-5 receptorEffective concentration determined against melanocortin-5 receptor	ChEMBL	649	10	2	6	3.6	CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.01.060
	CHEMBL181162	64327	None	0	Human	Functional	pEC50	=	6.8	6.8	-61	3	Effective concentration determined against melanocortin-5 receptorEffective concentration determined against melanocortin-5 receptor	ChEMBL	649	10	2	6	3.6	CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.01.060
	44347221	16633	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL124169	16633	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	9852256	175365	None	0	Mouse	Functional	pEC50	=	5.8	5.8	-4	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	632	15	8	7	0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	CHEMBL4574756	175365	None	0	Mouse	Functional	pEC50	=	5.8	5.8	-4	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	632	15	8	7	0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	164609931	184495	None	0	Mouse	Functional	pEC50	=	5.8	5.8	3	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	529	12	3	3	5.6	CC(C)CCCN1C(=N)N([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C[C@H]1C(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL4847357	184495	None	0	Mouse	Functional	pEC50	=	5.8	5.8	3	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	529	12	3	3	5.6	CC(C)CCCN1C(=N)N([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C[C@H]1C(C)C	10.1021/acs.jmedchem.0c02041
	44457021	97899	None	0	Mouse	Functional	pEC50	=	4.8	4.8	-9	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	399	6	4	3	2.2	N=C(N)NCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O	10.1021/jm701303z
	CHEMBL272439	97899	None	0	Mouse	Functional	pEC50	=	4.8	4.8	-9	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	399	6	4	3	2.2	N=C(N)NCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O	10.1021/jm701303z
	44441646	154086	None	0	Human	Functional	pEC50	=	5.8	5.8	-23	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	611	9	2	7	3.7	Cn1nnnc1CC1(Cc2ccccc2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL398487	154086	None	0	Human	Functional	pEC50	=	5.8	5.8	-23	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	611	9	2	7	3.7	Cn1nnnc1CC1(Cc2ccccc2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	45487288	197354	None	0	Mouse	Functional	pEC50	=	4.8	4.8	-14	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	623	16	8	6	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(F)cc1F)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569076	197354	None	0	Mouse	Functional	pEC50	=	4.8	4.8	-14	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	623	16	8	6	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(F)cc1F)C(N)=O	10.1016/j.bmcl.2009.07.025
	46885815	7858	None	0	Human	Functional	pEC50	=	4.8	4.8	-389	3	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	471	3	1	4	4.2	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccn1	10.1021/jm9017866
	CHEMBL1089830	7858	None	0	Human	Functional	pEC50	=	4.8	4.8	-389	3	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	471	3	1	4	4.2	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccn1	10.1021/jm9017866
	145964837	164345	None	0	Human	Functional	pEC50	=	7.8	7.8	-3	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	875	11	12	9	-0.5	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4212629	164345	None	0	Human	Functional	pEC50	=	7.8	7.8	-3	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	875	11	12	9	-0.5	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	137656489	159708	None	0	Mouse	Functional	pEC50	=	7.8	7.8	1	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1125	13	13	12	-1.2	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4104402	159708	None	0	Mouse	Functional	pEC50	=	7.8	7.8	1	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1125	13	13	12	-1.2	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	162666503	182228	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-16	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	696	15	7	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	CHEMBL4783292	182228	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-16	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	696	15	7	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	155558348	175034	None	0	Mouse	Functional	pEC50	=	7.8	7.8	5	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	677	19	9	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4567480	175034	None	0	Mouse	Functional	pEC50	=	7.8	7.8	5	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	677	19	9	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	132180653	175057	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-17	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	784	15	8	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4567961	175057	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-17	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	784	15	8	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL420167	213240	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL		None	None	None		NC(=O)[C@H]1CCCCNC(=O)C[C@H](N)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	CHEMBL427205	213350	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Activity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC1=O	10.1021/jm0510326
	164624627	185877	None	0	Mouse	Functional	pEC50	=	6.8	6.8	2	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	589	10	4	4	4.4	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4868223	185877	None	0	Mouse	Functional	pEC50	=	6.8	6.8	2	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	589	10	4	4	4.4	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	44431512	145922	None	0	Human	Functional	pEC50	=	6.8	6.8	-5	4	Effect on human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulationEffect on human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	1038	14	12	10	0.9	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	CHEMBL391796	145922	None	0	Human	Functional	pEC50	=	6.8	6.8	-5	4	Effect on human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulationEffect on human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	1038	14	12	10	0.9	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	46885759	8274	None	0	Human	Functional	pEC50	=	5.8	5.8	-295	3	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	488	3	1	3	4.9	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cccc(F)c1	10.1021/jm9017866
	CHEMBL1092548	8274	None	0	Human	Functional	pEC50	=	5.8	5.8	-295	3	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	488	3	1	3	4.9	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cccc(F)c1	10.1021/jm9017866
	164628926	186511	None	0	Mouse	Functional	pEC50	=	5.8	5.8	1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	543	14	3	3	6.2	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CCCC(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL4877537	186511	None	0	Mouse	Functional	pEC50	=	5.8	5.8	1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	543	14	3	3	6.2	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CCCC(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL3349030	211403	None	0	Human	Functional	pEC50	=	5.8	5.8	-8	3	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	71449119	78966	None	0	Human	Functional	pEC50	=	5.8	5.8	-117	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	643	7	3	6	4.2	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CNCCN2C(=O)OC(C)(C)C)CC1	10.1016/j.bmcl.2004.10.020
	CHEMBL2113028	78966	None	0	Human	Functional	pEC50	=	5.8	5.8	-117	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	643	7	3	6	4.2	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CNCCN2C(=O)OC(C)(C)C)CC1	10.1016/j.bmcl.2004.10.020
	155538874	172788	None	0	Mouse	Functional	pEC50	=	5.8	5.8	1	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	713	16	8	7	-1.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4513460	172788	None	0	Mouse	Functional	pEC50	=	5.8	5.8	1	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	713	16	8	7	-1.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	137649203	157506	None	0	Mouse	Functional	pEC50	=	4.8	4.8	-10	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	894	18	8	8	3.5	CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4079721	157506	None	0	Mouse	Functional	pEC50	=	4.8	4.8	-10	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	894	18	8	8	3.5	CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	45487289	197359	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-10	2	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	590	17	8	7	-0.6	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccnc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569104	197359	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-10	2	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	590	17	8	7	-0.6	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccnc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL2304250	209484	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-2	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	CHEMBL431242	213622	None	0	Mouse	Functional	pEC50	=	4.7	4.7	1	3	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	45487408	196852	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-5	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	617	17	8	7	0.1	COc1ccc(/C=C\C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CCCNC(=N)N)C(N)=O)cc1	10.1016/j.bmcl.2009.07.025
	CHEMBL565927	196852	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-5	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	617	17	8	7	0.1	COc1ccc(/C=C\C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CCCNC(=N)N)C(N)=O)cc1	10.1016/j.bmcl.2009.07.025
	164616640	184563	None	0	Mouse	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	543	13	3	3	6.0	CC(C)CCCN1C(=N)N([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C[C@H]1C(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL4848447	184563	None	0	Mouse	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	543	13	3	3	6.0	CC(C)CCCN1C(=N)N([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C[C@H]1C(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL268851	210767	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	71449047	78478	None	0	Human	Functional	pEC50	=	6.7	6.7	-40	3	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL2111807	78478	None	0	Human	Functional	pEC50	=	6.7	6.7	-40	3	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	44401323	11798	None	0	Human	Functional	pEC50	=	5.7	5.7	-72	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	569	7	4	5	3.1	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CNC3(CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL1181891	11798	None	0	Human	Functional	pEC50	=	5.7	5.7	-72	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	569	7	4	5	3.1	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CNC3(CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL2028961	11798	None	0	Human	Functional	pEC50	=	5.7	5.7	-72	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	569	7	4	5	3.1	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CNC3(CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	6918813	131369	None	3	Human	Functional	pEC50	=	5.7	5.7	-398	4	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL368876	131369	None	3	Human	Functional	pEC50	=	5.7	5.7	-398	4	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	45487291	197371	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-6	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	605	16	8	6	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C(F)=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569220	197371	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-6	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	605	16	8	6	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C(F)=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	11328898	7958	None	22	Human	Functional	pEC50	=	5.7	5.7	-165	4	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	470	3	1	3	4.8	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1090488	7958	None	22	Human	Functional	pEC50	=	5.7	5.7	-165	4	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	470	3	1	3	4.8	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1204059	7958	None	22	Human	Functional	pEC50	=	5.7	5.7	-165	4	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	470	3	1	3	4.8	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	44441687	94003	None	0	Human	Functional	pEC50	=	5.7	5.7	-43	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	571	7	3	5	3.3	CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3(C)CCCCC3)CC2)C1	10.1016/j.bmcl.2006.11.084
	CHEMBL248671	94003	None	0	Human	Functional	pEC50	=	5.7	5.7	-43	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	571	7	3	5	3.3	CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3(C)CCCCC3)CC2)C1	10.1016/j.bmcl.2006.11.084
	44396986	67430	None	0	Human	Functional	pEC50	=	5.7	5.7	-43	3	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	CHEMBL188966	67430	None	0	Human	Functional	pEC50	=	5.7	5.7	-43	3	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	CHEMBL2304246	209481	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-3	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	145971389	164631	None	0	Human	Functional	pEC50	=	8.7	8.7	-2	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4216242	164631	None	0	Human	Functional	pEC50	=	8.7	8.7	-2	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	15603023	97962	None	0	Mouse	Functional	pEC50	=	8.7	8.7	1	5	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL	849	12	10	8	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL272660	97962	None	0	Mouse	Functional	pEC50	=	8.7	8.7	1	5	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL	849	12	10	8	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	16132144	209277	None	36	Mouse	Functional	pEC50	=	8.7	8.7	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm701303z
	16133793	209277	None	36	Mouse	Functional	pEC50	=	8.7	8.7	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm701303z
	44273719	209277	None	36	Mouse	Functional	pEC50	=	8.7	8.7	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm701303z
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	8.7	8.7	-1	8	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm701303z
	CHEMBL444219	213928	None	0	Mouse	Functional	pEC50	=	8.7	8.7	-4	4	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	127046235	139636	None	0	Mouse	Functional	pEC50	=	8.7	8.7	2	5	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1004	36	12	13	-1.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3797690	139636	None	0	Mouse	Functional	pEC50	=	8.7	8.7	2	5	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1004	36	12	13	-1.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O	10.1021/acs.jmedchem.5b01894
	137656180	159026	None	0	Mouse	Functional	pEC50	=	8.7	8.7	5	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1005	12	12	11	-2.0	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4096678	159026	None	0	Mouse	Functional	pEC50	=	8.7	8.7	5	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1005	12	12	11	-2.0	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	155543031	173179	None	0	Mouse	Functional	pEC50	=	8.7	8.7	-3	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	803	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4522298	173179	None	0	Mouse	Functional	pEC50	=	8.7	8.7	-3	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	803	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL406891	212624	None	0	Mouse	Functional	pEC50	=	8.7	8.7	2	5	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CCSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	CHEMBL1688107	208832	None	0	Mouse	Functional	pEC50	=	8.6	8.6	-8	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	1325	3598	None	14	Mouse	Functional	pEC50	=	8.6	8.6	-3	5	Agonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassayAgonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b00184
	6440621	3598	None	14	Mouse	Functional	pEC50	=	8.6	8.6	-3	5	Agonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassayAgonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b00184
	9898183	3598	None	14	Mouse	Functional	pEC50	=	8.6	8.6	-3	5	Agonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassayAgonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b00184
	CHEMBL3422426	3598	None	14	Mouse	Functional	pEC50	=	8.6	8.6	-3	5	Agonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassayAgonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b00184
	CHEMBL3287327	211308	None	0	Mouse	Functional	pEC50	=	8.6	8.6	1	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	44400428	125675	None	0	Mouse	Functional	pEC50	=	8.6	8.6	-2	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	896	35	9	7	6.1	CCCCCCCCCCCCCCCCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL364726	125675	None	0	Mouse	Functional	pEC50	=	8.6	8.6	-2	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	896	35	9	7	6.1	CCCCCCCCCCCCCCCCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	44422999	168853	None	0	Human	Functional	pEC50	=	8.6	8.6	4	4	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL	1040	15	9	10	3.0	CCCC[C@H](NC(C)=O)C(=O)C[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	CHEMBL438118	168853	None	0	Human	Functional	pEC50	=	8.6	8.6	4	4	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL	1040	15	9	10	3.0	CCCC[C@H](NC(C)=O)C(=O)C[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	CHEMBL502093	214147	None	0	Mouse	Functional	pEC50	=	8.6	8.6	-2	3	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Br)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	1324	302	None	25	Mouse	Functional	pEC50	=	8.6	8.6	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	16154396	302	None	25	Mouse	Functional	pEC50	=	8.6	8.6	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	16197727	302	None	25	Mouse	Functional	pEC50	=	8.6	8.6	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	44285019	302	None	25	Mouse	Functional	pEC50	=	8.6	8.6	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	57514683	302	None	25	Mouse	Functional	pEC50	=	8.6	8.6	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	91898441	302	None	25	Mouse	Functional	pEC50	=	8.6	8.6	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	CHEMBL441738	302	None	25	Mouse	Functional	pEC50	=	8.6	8.6	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	DB04931	302	None	25	Mouse	Functional	pEC50	=	8.6	8.6	-5	9	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	CHEMBL370254	212164	None	3	Mouse	Functional	pEC50	=	8.6	8.6	6	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1	10.1021/jm0490843
	11263053	68018	None	0	Mouse	Functional	pEC50	=	8.6	8.6	-3	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	896	33	9	7	5.3	CCCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL191304	68018	None	0	Mouse	Functional	pEC50	=	8.6	8.6	-3	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	896	33	9	7	5.3	CCCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL448536	213957	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(C#N)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	11423083	96837	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-3	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	882	32	9	7	4.9	CCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL265236	96837	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-3	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	882	32	9	7	4.9	CCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	145948876	167481	None	0	Human	Functional	pEC50	=	7.7	7.7	-5	3	Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL4299441	167481	None	0	Human	Functional	pEC50	=	7.7	7.7	-5	3	Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	44456964	156688	None	0	Mouse	Functional	pEC50	=	7.7	7.7	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL	849	12	10	8	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL406985	156688	None	0	Mouse	Functional	pEC50	=	7.7	7.7	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL	849	12	10	8	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL204864	209164	None	0	Human	Functional	pEC50	=	6.7	6.7	-4	4	Activity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCC)NC1=O	10.1021/jm0510326
	137651071	157465	None	0	Mouse	Functional	pEC50	=	6.7	6.7	-25	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	794	15	7	6	1.3	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4079298	157465	None	0	Mouse	Functional	pEC50	=	6.7	6.7	-25	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	794	15	7	6	1.3	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL438920	213807	None	0	Human	Functional	pEC50	=	6.7	6.7	-26	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL433645	213641	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL		None	None	None		NC(=O)[C@H]1CCCCNC(=O)C[C@H](N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	CHEMBL409636	212771	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm030119t
	CHEMBL375947	212230	None	0	Human	Functional	pEC50	=	5.7	5.7	-1	4	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	155512534	169690	None	0	Mouse	Functional	pEC50	=	5.7	5.7	-22	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	642	16	7	6	1.4	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	CHEMBL4437801	169690	None	0	Mouse	Functional	pEC50	=	5.7	5.7	-22	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	642	16	7	6	1.4	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	CHEMBL320157	211224	None	0	Mouse	Functional	pEC50	=	5.7	5.7	1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	44391940	12248	None	0	Human	Functional	pEC50	=	5.7	5.7	-21	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	614	8	4	6	2.1	C[C@H](N)C(=O)N1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL1184624	12248	None	0	Human	Functional	pEC50	=	5.7	5.7	-21	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	614	8	4	6	2.1	C[C@H](N)C(=O)N1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL2145456	12248	None	0	Human	Functional	pEC50	=	5.7	5.7	-21	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	614	8	4	6	2.1	C[C@H](N)C(=O)N1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	46203215	8468	None	0	Human	Functional	pEC50	=	4.7	4.7	-27	2	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	428	3	1	3	3.6	C[C@H]1CN(C(=O)[C@@H]2CN(C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1093856	8468	None	0	Human	Functional	pEC50	=	4.7	4.7	-27	2	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	428	3	1	3	3.6	C[C@H]1CN(C(=O)[C@@H]2CN(C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1204065	8468	None	0	Human	Functional	pEC50	=	4.7	4.7	-27	2	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	428	3	1	3	3.6	C[C@H]1CN(C(=O)[C@@H]2CN(C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	44305712	102812	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-1	2	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	421	11	5	3	2.8	NCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	CHEMBL305391	102812	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-1	2	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	421	11	5	3	2.8	NCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	44359732	29073	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-2	2	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL	720	19	3	6	2.6	CC(=O)N(CC(=O)N(CC(=O)N(CCCCN=C(N)N)CC(=O)N(CC(N)=O)Cc1cccc2ccccc12)Cc1ccccc1)Cc1ccccc1	10.1016/j.bmcl.2003.08.078
	CHEMBL138100	29073	None	0	Mouse	Functional	pEC50	=	4.7	4.7	-2	2	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL	720	19	3	6	2.6	CC(=O)N(CC(=O)N(CC(=O)N(CCCCN=C(N)N)CC(=O)N(CC(N)=O)Cc1cccc2ccccc12)Cc1ccccc1)Cc1ccccc1	10.1016/j.bmcl.2003.08.078
	164616687	184622	None	0	Mouse	Functional	pEC50	=	5.7	5.7	11	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	523	13	3	3	5.0	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CCCC(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL4849344	184622	None	0	Mouse	Functional	pEC50	=	5.7	5.7	11	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	523	13	3	3	5.0	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CCCC(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL2323793	209517	None	0	Mouse	Functional	pEC50	=	6.7	6.7	-27	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	44335147	4590	None	0	Mouse	Functional	pEC50	=	5.7	5.7	4	4	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL	711	16	9	7	-0.3	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NC1(C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1	10.1021/jm010524p
	CHEMBL102688	4590	None	0	Mouse	Functional	pEC50	=	5.7	5.7	4	4	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL	711	16	9	7	-0.3	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NC1(C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1	10.1021/jm010524p
	CHEMBL524861	215621	None	0	Human	Functional	pEC50	=	7.7	7.7	3	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	54587278	60816	None	0	Human	Functional	pEC50	=	6.7	6.7	-138	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	587	6	3	4	4.7	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1762009	60816	None	0	Human	Functional	pEC50	=	6.7	6.7	-138	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	587	6	3	4	4.7	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	137639815	156800	None	0	Mouse	Functional	pEC50	=	6.7	6.7	-3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	847	20	11	8	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4071063	156800	None	0	Mouse	Functional	pEC50	=	6.7	6.7	-3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	847	20	11	8	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	6918780	63465	None	1	Human	Functional	pEC50	=	6.7	6.7	-204	2	Effective concentration determined against melanocortin-5 receptorEffective concentration determined against melanocortin-5 receptor	ChEMBL	637	10	2	6	3.6	CCCN(c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O	10.1016/j.bmcl.2005.01.060
	CHEMBL179836	63465	None	1	Human	Functional	pEC50	=	6.7	6.7	-204	2	Effective concentration determined against melanocortin-5 receptorEffective concentration determined against melanocortin-5 receptor	ChEMBL	637	10	2	6	3.6	CCCN(c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O	10.1016/j.bmcl.2005.01.060
	44347220	168438	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	861	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCC(C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL434985	168438	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	861	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCC(C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL2370965	209966	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	3	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	CHEMBL607104	215826	None	0	Mouse	Functional	pEC50	=	4.7	4.7	2	2	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	164621664	185565	None	0	Mouse	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	537	14	3	3	5.4	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CCCC(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL4863313	185565	None	0	Mouse	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	537	14	3	3	5.4	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CCCC(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL454736	213995	None	0	Mouse	Functional	pEC50	=	7.7	7.7	4	2	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL50056	214117	None	2	Mouse	Functional	pEC50	=	6.7	6.7	-8	7	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	44347331	16325	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	CHEMBL122773	16325	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	44441641	94299	None	0	Human	Functional	pEC50	=	6.7	6.7	-134	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	603	8	2	7	4.0	Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL250508	94299	None	0	Human	Functional	pEC50	=	6.7	6.7	-134	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	603	8	2	7	4.0	Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL3350327	211468	None	0	Mouse	Functional	pEC50	=	5.7	5.7	-13	4	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	44310258	159416	None	0	Mouse	Functional	pEC50	=	5.7	5.7	2	3	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	1421	24	20	20	-4.6	C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	91932908	159416	None	0	Mouse	Functional	pEC50	=	5.7	5.7	2	3	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	1421	24	20	20	-4.6	C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	CHEMBL410091	159416	None	0	Mouse	Functional	pEC50	=	5.7	5.7	2	3	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	1421	24	20	20	-4.6	C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	CHEMBL500516	214115	None	0	Mouse	Functional	pEC50	=	6.7	6.7	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(N)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	45487413	197249	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-1	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	616	15	10	7	-0.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1cc2cc(O)ccc2[nH]1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL568409	197249	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-1	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	616	15	10	7	-0.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1cc2cc(O)ccc2[nH]1)C(N)=O	10.1016/j.bmcl.2009.07.025
	44445083	154303	None	0	Human	Functional	pEC50	=	7.6	7.6	-2	3	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	953	9	10	9	2.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL398665	154303	None	0	Human	Functional	pEC50	=	7.6	7.6	-2	3	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	953	9	10	9	2.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	164609002	184383	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4845749	184383	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	9808720	64220	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Effective concentration determined against melanocortin-5 receptorEffective concentration determined against melanocortin-5 receptor	ChEMBL	595	8	3	6	2.8	CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.01.060
	CHEMBL180892	64220	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Effective concentration determined against melanocortin-5 receptorEffective concentration determined against melanocortin-5 receptor	ChEMBL	595	8	3	6	2.8	CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.01.060
	45487287	197647	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-3	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	633	17	8	8	-0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccc2c1OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL570903	197647	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-3	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	633	17	8	8	-0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccc2c1OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	46232224	201054	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-2	2	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	849	12	9	8	0.3	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL602654	201054	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-2	2	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	849	12	9	8	0.3	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	45487300	197357	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-7	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	605	15	8	8	-0.6	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1ccc2c(c1)OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569086	197357	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-7	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	605	15	8	8	-0.6	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1ccc2c(c1)OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	122184637	122434	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600918	122434	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	155565321	175574	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-7	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	718	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4579448	175574	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-7	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	718	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	44347331	16325	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	CHEMBL122773	16325	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	CHEMBL509582	215544	None	0	Human	Functional	pEC50	=	5.6	5.6	-6	3	Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm801300c
	44401585	13761	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	3	5	3.6	CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C	10.1016/j.bmcl.2005.02.068
	CHEMBL1195347	13761	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	3	5	3.6	CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C	10.1016/j.bmcl.2005.02.068
	CHEMBL554368	13761	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	3	5	3.6	CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C	10.1016/j.bmcl.2005.02.068
	15953833	78972	None	0	Human	Functional	pEC50	=	5.6	5.6	-57	4	Effective concentration against human melanocortin 5 receptor in cAMP release assayEffective concentration against human melanocortin 5 receptor in cAMP release assay	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL2113037	78972	None	0	Human	Functional	pEC50	=	5.6	5.6	-57	4	Effective concentration against human melanocortin 5 receptor in cAMP release assayEffective concentration against human melanocortin 5 receptor in cAMP release assay	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	155548791	173728	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-30	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	664	14	6	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4536340	173728	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-30	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	664	14	6	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	162670795	182824	None	0	Mouse	Functional	pEC50	=	7.6	7.6	-14	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	696	15	7	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	CHEMBL4791112	182824	None	0	Mouse	Functional	pEC50	=	7.6	7.6	-14	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	696	15	7	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	1323	2686	None	55	Human	Functional	pEC50	=	7.6	7.6	-181	8	Agonistic activity against human melanocortin receptor (hMC5R) for cAMP accumulationAgonistic activity against human melanocortin receptor (hMC5R) for cAMP accumulation	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00114-8
	92432	2686	None	55	Human	Functional	pEC50	=	7.6	7.6	-181	8	Agonistic activity against human melanocortin receptor (hMC5R) for cAMP accumulationAgonistic activity against human melanocortin receptor (hMC5R) for cAMP accumulation	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00114-8
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	7.6	7.6	-181	8	Agonistic activity against human melanocortin receptor (hMC5R) for cAMP accumulationAgonistic activity against human melanocortin receptor (hMC5R) for cAMP accumulation	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00114-8
	137649368	157404	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-35	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	844	15	7	6	2.4	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4078495	157404	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-35	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	844	15	7	6	2.4	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	44441644	154836	None	0	Human	Functional	pEC50	=	6.6	6.6	-66	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	577	9	2	7	3.5	CCC(C)C1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL400456	154836	None	0	Human	Functional	pEC50	=	6.6	6.6	-66	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	577	9	2	7	3.5	CCC(C)C1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL2310901	209496	None	0	Human	Functional	pEC50	=	6.6	6.6	-20	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	CHEMBL455070	213997	None	0	Human	Functional	pEC50	=	5.6	5.6	-25	3	Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm801300c
	44457067	97740	None	0	Mouse	Functional	pEC50	=	7.6	7.6	-5	5	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL	877	12	10	8	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCC(=O)NCCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL271586	97740	None	0	Mouse	Functional	pEC50	=	7.6	7.6	-5	5	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL	877	12	10	8	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCC(=O)NCCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	162654633	180642	None	0	Mouse	Functional	pEC50	=	7.6	7.6	-29	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4754987	180642	None	0	Mouse	Functional	pEC50	=	7.6	7.6	-29	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	137636060	156229	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-2	2	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	850	15	7	7	2.5	CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4064728	156229	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-2	2	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	850	15	7	7	2.5	CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	44335147	4590	None	0	Mouse	Functional	pEC50	=	6.6	6.6	4	4	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL	711	16	9	7	-0.3	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NC1(C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1	10.1021/jm010524p
	CHEMBL102688	4590	None	0	Mouse	Functional	pEC50	=	6.6	6.6	4	4	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL	711	16	9	7	-0.3	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NC1(C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1	10.1021/jm010524p
	CHEMBL3350396	211477	None	0	Human	Functional	pEC50	=	6.6	6.6	-371	4	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	CHEMBL376614	212250	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(O)cc2)N(CC)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	CHEMBL2323790	209514	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-8	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	137653916	158578	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	828	18	9	8	1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4091894	158578	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	828	18	9	8	1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	155567887	176046	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	676	19	10	7	-1.1	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	CHEMBL4590532	176046	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	676	19	10	7	-1.1	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	CHEMBL263878	210596	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	CHEMBL3349030	211403	None	0	Human	Functional	pEC50	=	5.6	5.6	-8	3	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	44392015	12776	None	0	Human	Functional	pEC50	=	5.6	5.6	-41	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCN[C@@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL1187982	12776	None	0	Human	Functional	pEC50	=	5.6	5.6	-41	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCN[C@@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL3216179	12776	None	0	Human	Functional	pEC50	=	5.6	5.6	-41	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCN[C@@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	1338	3805	None	43	Human	Functional	pEC50	=	5.6	5.6	-660	8	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/s0960-894x(03)00796-0
	9938402	3805	None	43	Human	Functional	pEC50	=	5.6	5.6	-660	8	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/s0960-894x(03)00796-0
	CHEMBL339053	3805	None	43	Human	Functional	pEC50	=	5.6	5.6	-660	8	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/s0960-894x(03)00796-0
	155545201	173445	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-1	2	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	602	14	6	7	-0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4529287	173445	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-1	2	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	602	14	6	7	-0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	10864861	115198	None	4	Human	Functional	pEC50	=	6.6	6.6	-128	2	Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulation	ChEMBL	588	8	2	6	4.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1)[C@@H]1Cc2ccccc2CN1	10.1021/jm025539h
	CHEMBL334457	115198	None	4	Human	Functional	pEC50	=	6.6	6.6	-128	2	Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulation	ChEMBL	588	8	2	6	4.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1)[C@@H]1Cc2ccccc2CN1	10.1021/jm025539h
	45487411	197043	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-10	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	603	16	9	7	-0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(O)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL567240	197043	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-10	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	603	16	9	7	-0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(O)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL266417	210681	None	0	Human	Functional	pEC50	=	7.6	7.6	-776	6	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm010165y
	CHEMBL2370963	209964	None	0	Human	Functional	pEC50	=	7.6	7.6	85	2	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	44408190	96921	None	0	Human	Functional	pEC50	=	6.6	6.6	-46	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	606	8	2	5	4.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCOC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL265985	96921	None	0	Human	Functional	pEC50	=	6.6	6.6	-46	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	606	8	2	5	4.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCOC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	10257242	15028	None	0	Human	Functional	pEC50	=	5.6	5.6	-42	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	560	7	0	4	5.1	CC(=O)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	CHEMBL1209252	15028	None	0	Human	Functional	pEC50	=	5.6	5.6	-42	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	560	7	0	4	5.1	CC(=O)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	CHEMBL430843	213619	None	0	Mouse	Functional	pEC50	=	5.6	5.6	2	3	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](CCc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	122178163	121255	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-2	2	Agonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassayAgonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassay	ChEMBL	998	10	10	10	0.5	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)c2cc3ccccc3cc2NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577992	121255	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-2	2	Agonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassayAgonist activity at mouse MC5R expressed in HEK293 cells by cAMP functional bioassay	ChEMBL	998	10	10	10	0.5	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)c2cc3ccccc3cc2NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	155554244	174947	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-15	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	630	15	8	7	-0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4565607	174947	None	0	Mouse	Functional	pEC50	=	4.6	4.6	-15	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	630	15	8	7	-0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	44305763	203084	None	0	Mouse	Functional	pEC50	=	4.5	4.5	-1	4	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	490	11	5	4	3.1	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCC(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	CHEMBL63850	203084	None	0	Mouse	Functional	pEC50	=	4.5	4.5	-1	4	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	490	11	5	4	3.1	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCC(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	CHEMBL2323786	209510	None	0	Mouse	Functional	pEC50	=	7.5	7.5	-2	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	16132144	209277	None	36	Human	Functional	pEC50	=	7.5	7.5	-81	8	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00796-0
	16133793	209277	None	36	Human	Functional	pEC50	=	7.5	7.5	-81	8	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00796-0
	44273719	209277	None	36	Human	Functional	pEC50	=	7.5	7.5	-81	8	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00796-0
	CHEMBL214332	209277	None	36	Human	Functional	pEC50	=	7.5	7.5	-81	8	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00796-0
	137646614	157536	None	0	Mouse	Functional	pEC50	=	5.5	5.5	-8	2	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	822	18	9	7	0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4080138	157536	None	0	Mouse	Functional	pEC50	=	5.5	5.5	-8	2	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	822	18	9	7	0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	46232222	201053	None	0	Mouse	Functional	pEC50	=	5.5	5.5	-4	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	835	12	8	8	0.2	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL602653	201053	None	0	Mouse	Functional	pEC50	=	5.5	5.5	-4	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	835	12	8	8	0.2	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	44441648	154689	None	0	Human	Functional	pEC50	=	5.5	5.5	-41	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	605	8	2	8	2.9	Cn1nnnc1CC1(C2CCOCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL399715	154689	None	0	Human	Functional	pEC50	=	5.5	5.5	-41	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	605	8	2	8	2.9	Cn1nnnc1CC1(C2CCOCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	137635422	155908	None	0	Human	Functional	pEC50	=	6.5	6.5	-72	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1111	22	15	16	-2.3	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4060816	155908	None	0	Human	Functional	pEC50	=	6.5	6.5	-72	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1111	22	15	16	-2.3	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL264190	210606	None	1	Mouse	Functional	pEC50	=	8.5	8.5	2	8	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	90643805	111743	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-1	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287325	111743	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-1	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	155544214	173329	None	0	Mouse	Functional	pEC50	=	8.5	8.5	1	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	797	20	11	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4526652	173329	None	0	Mouse	Functional	pEC50	=	8.5	8.5	1	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	797	20	11	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	155549760	173875	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-7	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	711	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4539621	173875	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-7	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	711	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	155550083	173912	None	0	Mouse	Functional	pEC50	=	8.5	8.5	5	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	775	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4540411	173912	None	0	Mouse	Functional	pEC50	=	8.5	8.5	5	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	775	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	11308957	69391	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-1	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	868	31	9	7	4.5	CCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL193151	69391	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-1	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	868	31	9	7	4.5	CCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL264190	210606	None	1	Mouse	Functional	pEC50	=	8.5	8.5	2	8	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	127047475	139747	None	0	Mouse	Functional	pEC50	=	8.5	8.5	1	5	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1630	54	21	19	-1.2	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	132991507	139747	None	0	Mouse	Functional	pEC50	=	8.5	8.5	1	5	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1630	54	21	19	-1.2	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3798421	139747	None	0	Mouse	Functional	pEC50	=	8.5	8.5	1	5	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1630	54	21	19	-1.2	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL439128	213823	None	0	Human	Functional	pEC50	=	8.5	8.5	1	3	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	CHEMBL3358533	211565	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-7	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C#CC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL264190	210606	None	1	Mouse	Functional	pEC50	=	8.5	8.5	2	8	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	1323	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Activity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm0510326
	92432	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Activity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm0510326
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Activity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm0510326
	1323	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Activity at hMC5R transfected in HEK293 cells assessed as intracellular cAMP accumulationActivity at hMC5R transfected in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm060768f
	92432	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Activity at hMC5R transfected in HEK293 cells assessed as intracellular cAMP accumulationActivity at hMC5R transfected in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm060768f
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Activity at hMC5R transfected in HEK293 cells assessed as intracellular cAMP accumulationActivity at hMC5R transfected in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm060768f
	1323	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm070461w
	92432	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm070461w
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm070461w
	1323	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	92432	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	1323	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		None	10.1021/jm801300c
	92432	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		None	10.1021/jm801300c
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		None	10.1021/jm801300c
	1323	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	92432	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.5	8.5	-181	8	Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	CHEMBL393075	212460	None	0	Human	Functional	pEC50	=	8.5	8.5	-20	4	Effect on human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulationEffect on human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2007.02.020
	11239907	133125	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-5	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	854	30	9	7	4.1	CCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL370261	133125	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-5	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	854	30	9	7	4.1	CCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	155564058	175332	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-16	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	746	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4574056	175332	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-16	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	746	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL264190	210606	None	1	Mouse	Functional	pEC50	=	8.5	8.5	2	8	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	162673830	183157	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-15	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	753	18	10	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4795352	183157	None	0	Mouse	Functional	pEC50	=	8.5	8.5	-15	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	753	18	10	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL2370964	209965	None	0	Human	Functional	pEC50	=	8.4	8.4	-10	4	Agonist activity at human MC5R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assayAgonist activity at human MC5R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/acs.jmedchem.1c01295
	CHEMBL4299619	213593	None	0	Mouse	Functional	pEC50	=	8.4	8.4	2	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL2370964	209965	None	0	Human	Functional	pEC50	=	8.4	8.4	-10	4	Agonist activity at human MC5R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assayAgonist activity at human MC5R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/acs.jmedchem.1c01295
	CHEMBL264190	210606	None	1	Human	Functional	pEC50	=	8.4	8.4	-3	8	Agonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	127047913	139922	None	0	Mouse	Functional	pEC50	=	8.4	8.4	4	5	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	962	35	12	13	-1.5	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3799563	139922	None	0	Mouse	Functional	pEC50	=	8.4	8.4	4	5	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	962	35	12	13	-1.5	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL264190	210606	None	1	Mouse	Functional	pEC50	=	8.4	8.4	2	8	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	164612516	185391	None	0	Mouse	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4860714	185391	None	0	Mouse	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL510687	215585	None	0	Mouse	Functional	pEC50	=	7.5	7.5	-3	4	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1cccc(Cl)c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	155556047	174495	None	0	Mouse	Functional	pEC50	=	7.5	7.5	1	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	683	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4554828	174495	None	0	Mouse	Functional	pEC50	=	7.5	7.5	1	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	683	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL203602	209158	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Activity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm0510326
	155531140	171616	None	0	Mouse	Functional	pEC50	=	6.5	6.5	1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	666	16	8	7	0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	CHEMBL4465466	171616	None	0	Mouse	Functional	pEC50	=	6.5	6.5	1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	666	16	8	7	0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	44401530	12793	None	0	Human	Functional	pEC50	=	6.5	6.5	-51	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	597	8	4	5	3.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@@H](C3(C)CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL1188092	12793	None	0	Human	Functional	pEC50	=	6.5	6.5	-51	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	597	8	4	5	3.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@@H](C3(C)CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL535152	12793	None	0	Human	Functional	pEC50	=	6.5	6.5	-51	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	597	8	4	5	3.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@@H](C3(C)CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	44347119	114421	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	752	9	10	7	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL333178	114421	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	752	9	10	7	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	45487405	197435	None	0	Mouse	Functional	pEC50	=	4.5	4.5	-25	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	587	16	8	6	0.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569695	197435	None	0	Mouse	Functional	pEC50	=	4.5	4.5	-25	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	587	16	8	6	0.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	51350673	58798	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-1	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	53317148	58798	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-1	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	91932362	58798	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-1	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL1688104	58798	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-1	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	44305790	102838	None	0	Mouse	Functional	pEC50	=	4.5	4.5	-1	3	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	407	10	5	3	2.4	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	CHEMBL305559	102838	None	0	Mouse	Functional	pEC50	=	4.5	4.5	-1	3	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	407	10	5	3	2.4	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	45487294	196811	None	0	Mouse	Functional	pEC50	=	5.5	5.5	-3	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	601	17	8	6	0.5	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C/C=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL565688	196811	None	0	Mouse	Functional	pEC50	=	5.5	5.5	-3	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	601	17	8	6	0.5	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C/C=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL2371973	210168	None	0	Human	Functional	pEC50	=	7.5	7.5	57	2	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(Cc3ccccc3)cc2)NC(=O)[C@@H]2CC3CCCCC3N2C1=O	10.1021/jm0614275
	162661724	181533	None	0	Mouse	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	668	14	5	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	CHEMBL4765199	181533	None	0	Mouse	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	668	14	5	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	162664463	182188	None	0	Mouse	Functional	pEC50	=	7.5	7.5	4	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	706	15	6	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4782762	182188	None	0	Mouse	Functional	pEC50	=	7.5	7.5	4	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	706	15	6	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	46232223	199162	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-1	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	849	12	9	8	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL589468	199162	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-1	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	849	12	9	8	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL302703	210912	None	0	Mouse	Functional	pEC50	=	6.5	6.5	5	5	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	46232228	201021	None	0	Mouse	Functional	pEC50	=	6.5	6.5	3	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	863	12	8	8	1.0	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL602299	201021	None	0	Mouse	Functional	pEC50	=	6.5	6.5	3	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	863	12	8	8	1.0	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	44456958	97402	None	0	Mouse	Functional	pEC50	=	5.5	5.5	2	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	308	4	1	2	2.8	CCCN1C(=O)C(Cc2ccccc2)NC(=O)c2ccccc21	10.1021/jm701303z
	CHEMBL269837	97402	None	0	Mouse	Functional	pEC50	=	5.5	5.5	2	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	308	4	1	2	2.8	CCCN1C(=O)C(Cc2ccccc2)NC(=O)c2ccccc21	10.1021/jm701303z
	CHEMBL104880	208463	None	0	Mouse	Functional	pEC50	=	4.5	4.5	1	2	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	44305704	203335	None	0	Mouse	Functional	pEC50	=	4.5	4.5	-1	4	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	407	10	5	3	2.4	NCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	CHEMBL64954	203335	None	0	Mouse	Functional	pEC50	=	4.5	4.5	-1	4	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	407	10	5	3	2.4	NCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	44275650	94052	None	0	Human	Functional	pEC50	=	7.5	7.5	-83	4	Agonistic activity against human melanocortin receptor (hMC5R) for cAMP accumulationAgonistic activity against human melanocortin receptor (hMC5R) for cAMP accumulation	ChEMBL	953	15	12	10	-0.8	CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O	10.1016/s0960-894x(03)00114-8
	CHEMBL24892	94052	None	0	Human	Functional	pEC50	=	7.5	7.5	-83	4	Agonistic activity against human melanocortin receptor (hMC5R) for cAMP accumulationAgonistic activity against human melanocortin receptor (hMC5R) for cAMP accumulation	ChEMBL	953	15	12	10	-0.8	CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O	10.1016/s0960-894x(03)00114-8
	1323	2686	None	55	Human	Functional	pEC50	=	7.5	7.5	-181	8	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	92432	2686	None	55	Human	Functional	pEC50	=	7.5	7.5	-181	8	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	7.5	7.5	-181	8	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	137645483	157616	None	0	Mouse	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	906	11	11	10	-1.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4081092	157616	None	0	Mouse	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	906	11	11	10	-1.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.6b01707
	44391927	13989	None	0	Human	Functional	pEC50	=	5.5	5.5	-66	3	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCNC[C@H]1C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C2CCCCC2)CC1	10.1016/j.bmcl.2004.10.020
	CHEMBL1196971	13989	None	0	Human	Functional	pEC50	=	5.5	5.5	-66	3	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCNC[C@H]1C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C2CCCCC2)CC1	10.1016/j.bmcl.2004.10.020
	CHEMBL3216393	13989	None	0	Human	Functional	pEC50	=	5.5	5.5	-66	3	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCNC[C@H]1C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C2CCCCC2)CC1	10.1016/j.bmcl.2004.10.020
	53318436	58801	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-2	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	814	17	10	9	-0.4	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H]1CSCC(=O)N([C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C[C@H](CCCNC(=N)N)NC1=O	10.1021/jm101425m
	CHEMBL1688108	58801	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-2	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	814	17	10	9	-0.4	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H]1CSCC(=O)N([C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C[C@H](CCCNC(=N)N)NC1=O	10.1021/jm101425m
	CHEMBL103817	208457	None	0	Mouse	Functional	pEC50	=	7.5	7.5	-2	4	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	44408286	140666	None	0	Human	Functional	pEC50	=	6.5	6.5	-117	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	634	8	2	5	5.5	CC1(C)COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL381501	140666	None	0	Human	Functional	pEC50	=	6.5	6.5	-117	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	634	8	2	5	5.5	CC1(C)COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	137658359	159569	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-6	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	791	20	11	7	-1.0	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4102774	159569	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-6	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	791	20	11	7	-1.0	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL488355	214073	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-3	3	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(C(C)(C)C)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	164619151	185552	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	610	11	4	4	5.5	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4863206	185552	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	610	11	4	4	5.5	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	44401522	12782	None	0	Human	Functional	pEC50	=	6.5	6.5	-97	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	4	5	3.5	CC(C)[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	CHEMBL1188041	12782	None	0	Human	Functional	pEC50	=	6.5	6.5	-97	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	4	5	3.5	CC(C)[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	CHEMBL534928	12782	None	0	Human	Functional	pEC50	=	6.5	6.5	-97	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	4	5	3.5	CC(C)[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	44391938	11744	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	599	9	3	5	3.9	CC(C)CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL1181567	11744	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	599	9	3	5	3.9	CC(C)CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL2145455	11744	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	599	9	3	5	3.9	CC(C)CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	45487417	197042	None	0	Mouse	Functional	pEC50	=	5.5	5.5	-8	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	617	17	8	7	0.1	COc1ccc(/C=C/C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CCCNC(=N)N)C(N)=O)cc1	10.1016/j.bmcl.2009.07.025
	CHEMBL567233	197042	None	0	Mouse	Functional	pEC50	=	5.5	5.5	-8	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	617	17	8	7	0.1	COc1ccc(/C=C/C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CCCNC(=N)N)C(N)=O)cc1	10.1016/j.bmcl.2009.07.025
	CHEMBL602650	215815	None	0	Mouse	Functional	pEC50	=	5.5	5.5	2	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)NCC(=O)N(CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)Cc1ccccc1	10.1016/j.bmc.2009.12.010
	16157270	212551	None	14	Mouse	Functional	pEC50	=	7.5	7.5	-22	7	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/acs.jmedchem.5b01894
	CHEMBL405282	212551	None	14	Mouse	Functional	pEC50	=	7.5	7.5	-22	7	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/acs.jmedchem.5b01894
	16132144	209277	None	36	Human	Functional	pEC50	=	7.5	7.5	-81	8	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00353
	16133793	209277	None	36	Human	Functional	pEC50	=	7.5	7.5	-81	8	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00353
	44273719	209277	None	36	Human	Functional	pEC50	=	7.5	7.5	-81	8	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00353
	CHEMBL214332	209277	None	36	Human	Functional	pEC50	=	7.5	7.5	-81	8	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00353
	CHEMBL2323799	209523	None	0	Mouse	Functional	pEC50	=	6.5	6.5	-22	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	46232225	201080	None	0	Mouse	Functional	pEC50	=	6.5	6.5	4	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	849	12	8	8	0.6	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL602852	201080	None	0	Mouse	Functional	pEC50	=	6.5	6.5	4	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	849	12	8	8	0.6	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)C(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	46885761	8026	None	0	Human	Functional	pEC50	=	5.5	5.5	-56	4	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	506	3	1	3	5.1	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1F	10.1021/jm9017866
	CHEMBL1090813	8026	None	0	Human	Functional	pEC50	=	5.5	5.5	-56	4	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	506	3	1	3	5.1	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1F	10.1021/jm9017866
	CHEMBL441988	213903	None	4	Mouse	Functional	pEC50	=	7.4	7.4	162	2	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.5b00053
	162665266	182179	None	0	Mouse	Functional	pEC50	=	7.4	7.4	1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	668	14	5	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	CHEMBL4782693	182179	None	0	Mouse	Functional	pEC50	=	7.4	7.4	1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	668	14	5	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	CHEMBL389674	212431	None	0	Human	Functional	pEC50	=	6.4	6.4	1	4	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	16132144	209277	None	36	Human	Functional	pEC50	=	6.4	6.4	-81	8	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm9017866
	16133793	209277	None	36	Human	Functional	pEC50	=	6.4	6.4	-81	8	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm9017866
	44273719	209277	None	36	Human	Functional	pEC50	=	6.4	6.4	-81	8	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm9017866
	CHEMBL214332	209277	None	36	Human	Functional	pEC50	=	6.4	6.4	-81	8	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm9017866
	CHEMBL138771	208752	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-1	3	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL		None	None	None		CC(=O)N(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)Cc1ccccc1	10.1016/j.bmcl.2003.08.078
	44401528	13987	None	0	Human	Functional	pEC50	=	6.4	6.4	-61	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	599	7	4	5	3.9	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@@H](C(C)(C)C)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL1196956	13987	None	0	Human	Functional	pEC50	=	6.4	6.4	-61	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	599	7	4	5	3.9	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@@H](C(C)(C)C)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL558787	13987	None	0	Human	Functional	pEC50	=	6.4	6.4	-61	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	599	7	4	5	3.9	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@@H](C(C)(C)C)CN2)CC1	10.1016/j.bmcl.2005.02.068
	44408253	140342	None	0	Human	Functional	pEC50	=	5.4	5.4	-141	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	650	10	2	5	6.1	CCOC(=O)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)C(C)C	10.1016/j.bmcl.2005.11.095
	CHEMBL380727	140342	None	0	Human	Functional	pEC50	=	5.4	5.4	-141	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	650	10	2	5	6.1	CCOC(=O)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)C(C)C	10.1016/j.bmcl.2005.11.095
	46885712	8069	None	0	Human	Functional	pEC50	=	5.4	5.4	-204	4	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	488	3	1	3	4.9	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1	10.1021/jm9017866
	CHEMBL1091151	8069	None	0	Human	Functional	pEC50	=	5.4	5.4	-204	4	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	488	3	1	3	4.9	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1	10.1021/jm9017866
	CHEMBL1204061	8069	None	0	Human	Functional	pEC50	=	5.4	5.4	-204	4	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	488	3	1	3	4.9	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1	10.1021/jm9017866
	CHEMBL104052	208460	None	0	Mouse	Functional	pEC50	=	4.4	4.4	-1	2	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	46885972	8117	None	0	Human	Functional	pEC50	=	5.4	5.4	-52	4	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	456	4	1	3	4.4	CC(C)N1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1	10.1021/jm9017866
	CHEMBL1091631	8117	None	0	Human	Functional	pEC50	=	5.4	5.4	-52	4	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	456	4	1	3	4.4	CC(C)N1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1	10.1021/jm9017866
	145980719	166494	None	0	Human	Functional	pEC50	=	7.4	7.4	1	4	Agonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	642	17	7	6	1.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4278563	166494	None	0	Human	Functional	pEC50	=	7.4	7.4	1	4	Agonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	642	17	7	6	1.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	44448660	94971	None	0	Human	Functional	pEC50	=	6.4	6.4	-245	4	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	575	6	1	3	6.9	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL254589	94971	None	0	Human	Functional	pEC50	=	6.4	6.4	-245	4	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	575	6	1	3	6.9	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	137637656	156236	None	0	Human	Functional	pEC50	=	6.4	6.4	-40	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1045	20	14	15	-2.2	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4064777	156236	None	0	Human	Functional	pEC50	=	6.4	6.4	-40	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1045	20	14	15	-2.2	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	164626210	186488	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	670	12	4	4	7.0	CC[C@H](C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccc(O)cc1)N1C[C@@H](Cc2ccccc2)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4877184	186488	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	670	12	4	4	7.0	CC[C@H](C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccc(O)cc1)N1C[C@@H](Cc2ccccc2)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	44441643	154798	None	0	Human	Functional	pEC50	=	6.4	6.4	-43	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	591	8	2	7	3.9	Cn1nnnc1CC1(CC(C)(C)C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL400252	154798	None	0	Human	Functional	pEC50	=	6.4	6.4	-43	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	591	8	2	7	3.9	Cn1nnnc1CC1(CC(C)(C)C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	44347927	157274	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Effective concentration of peptide at 50% maximal cAMP generation (10e-10 to 10e-4 M)Effective concentration of peptide at 50% maximal cAMP generation (10e-10 to 10e-4 M)	ChEMBL	1443	31	14	21	-1.9	CC(=O)[C@@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL407680	157274	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Effective concentration of peptide at 50% maximal cAMP generation (10e-10 to 10e-4 M)Effective concentration of peptide at 50% maximal cAMP generation (10e-10 to 10e-4 M)	ChEMBL	1443	31	14	21	-1.9	CC(=O)[C@@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	162662213	181494	None	0	Mouse	Functional	pEC50	=	7.4	7.4	2	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	706	15	6	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4764827	181494	None	0	Mouse	Functional	pEC50	=	7.4	7.4	2	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	706	15	6	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	44457043	97610	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-3	5	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL	883	12	10	8	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL270923	97610	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-3	5	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL	883	12	10	8	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	51350799	58799	None	0	Mouse	Functional	pEC50	=	6.4	6.4	3	3	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	53323763	58799	None	0	Mouse	Functional	pEC50	=	6.4	6.4	3	3	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	91932356	58799	None	0	Mouse	Functional	pEC50	=	6.4	6.4	3	3	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL1688105	58799	None	0	Mouse	Functional	pEC50	=	6.4	6.4	3	3	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	1334	1500	None	7	Human	Functional	pEC50	=	6.4	6.4	-17	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16133814	1500	None	7	Human	Functional	pEC50	=	6.4	6.4	-17	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL437050	1500	None	7	Human	Functional	pEC50	=	6.4	6.4	-17	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	44310243	169185	None	0	Mouse	Functional	pEC50	=	5.4	5.4	2	3	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	1421	24	20	20	-4.6	C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	91932909	169185	None	0	Mouse	Functional	pEC50	=	5.4	5.4	2	3	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	1421	24	20	20	-4.6	C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	CHEMBL440633	169185	None	0	Mouse	Functional	pEC50	=	5.4	5.4	2	3	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL	1421	24	20	20	-4.6	C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NN)CC(=O)NC(C(=O)NN[C@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	46232221	199167	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-1	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	835	12	9	8	-0.1	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL589516	199167	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-1	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	835	12	9	8	-0.1	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	44305805	100880	None	0	Mouse	Functional	pEC50	=	4.4	4.4	1	2	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	393	9	5	3	2.0	NCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	CHEMBL293673	100880	None	0	Mouse	Functional	pEC50	=	4.4	4.4	1	2	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	393	9	5	3	2.0	NCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	CHEMBL264190	210606	None	1	Mouse	Functional	pEC50	=	8.4	8.4	2	8	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.5b00053
	127047853	139991	None	0	Mouse	Functional	pEC50	=	8.4	8.4	4	5	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1948	72	23	25	-2.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3799955	139991	None	0	Mouse	Functional	pEC50	=	8.4	8.4	4	5	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1948	72	23	25	-2.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL264190	210606	None	1	Mouse	Functional	pEC50	=	8.4	8.4	2	8	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2003.08.078
	155539948	172884	None	0	Mouse	Functional	pEC50	=	8.4	8.4	-1	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	705	20	11	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4515666	172884	None	0	Mouse	Functional	pEC50	=	8.4	8.4	-1	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	705	20	11	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL2370968	209969	None	0	Human	Functional	pEC50	=	8.4	8.4	-1	4	Agonist activity at human MC5R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assayAgonist activity at human MC5R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/acs.jmedchem.1c01295
	CHEMBL2370968	209969	None	0	Human	Functional	pEC50	=	8.4	8.4	-1	4	Agonist activity at human MC5R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assayAgonist activity at human MC5R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/acs.jmedchem.1c01295
	CHEMBL264190	210606	None	1	Mouse	Functional	pEC50	=	8.4	8.4	2	8	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.0c02041
	CHEMBL385465	212349	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL		None	None	None		CC(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm010165y
	CHEMBL405791	212578	None	0	Mouse	Functional	pEC50	=	8.4	8.4	1	4	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ncc[nH]2)C(=O)N[C@H](Cc2cccc3ccccc23)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	11491374	67618	None	0	Mouse	Functional	pEC50	=	8.4	8.4	-4	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	840	29	9	7	3.7	CCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL190366	67618	None	0	Mouse	Functional	pEC50	=	8.4	8.4	-4	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	840	29	9	7	3.7	CCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	155567399	175964	None	0	Mouse	Functional	pEC50	=	8.3	8.3	17	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	769	19	9	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4588429	175964	None	0	Mouse	Functional	pEC50	=	8.3	8.3	17	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	769	19	9	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	11181928	166155	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-1	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	797	26	9	7	2.5	CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL426282	166155	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-1	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL	797	26	9	7	2.5	CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL3799094	212266	None	0	Mouse	Functional	pEC50	=	8.3	8.3	8	5	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	137644449	158290	None	0	Mouse	Functional	pEC50	=	7.4	7.4	3	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1016	12	11	10	-0.7	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4088980	158290	None	0	Mouse	Functional	pEC50	=	7.4	7.4	3	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1016	12	11	10	-0.7	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	155542040	173076	None	0	Mouse	Functional	pEC50	=	7.4	7.4	-199	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	654	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4519837	173076	None	0	Mouse	Functional	pEC50	=	7.4	7.4	-199	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	654	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	155549865	173854	None	0	Mouse	Functional	pEC50	=	7.4	7.4	10	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	658	17	7	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4539175	173854	None	0	Mouse	Functional	pEC50	=	7.4	7.4	10	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	658	17	7	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	44408287	75384	None	0	Human	Functional	pEC50	=	6.4	6.4	-162	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	620	8	2	5	5.1	C[C@@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL203911	75384	None	0	Human	Functional	pEC50	=	6.4	6.4	-162	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	620	8	2	5	5.1	C[C@@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	44408275	75417	None	0	Human	Functional	pEC50	=	6.4	6.4	-47	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	620	8	2	5	5.1	C[C@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL204078	75417	None	0	Human	Functional	pEC50	=	6.4	6.4	-47	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	620	8	2	5	5.1	C[C@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL3287060	211297	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-6	5	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	CHEMBL317228	211198	None	0	Mouse	Functional	pEC50	=	5.4	5.4	3	4	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)c1ccccc1	10.1021/jm010524p
	155558598	174758	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-1	2	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	656	13	5	6	-0.3	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4561005	174758	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-1	2	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	656	13	5	6	-0.3	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL2096759	209206	None	0	Human	Functional	pEC50	=	6.4	6.4	-23	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	137640715	157001	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-56	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	850	15	7	7	2.5	CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4073316	157001	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-56	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	850	15	7	7	2.5	CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	118735100	118798	None	0	Human	Functional	pEC50	=	5.4	5.4	-91	4	Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterAntagonist activity at human MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL	764	15	9	6	1.8	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(F)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421677	118798	None	0	Human	Functional	pEC50	=	5.4	5.4	-91	4	Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterAntagonist activity at human MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL	764	15	9	6	1.8	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(F)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL104010	208459	None	0	Mouse	Functional	pEC50	=	4.4	4.4	-1	2	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	CHEMBL2323789	209513	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-213	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	CHEMBL2370553	209868	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL		None	None	None		CC(=O)N[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm010165y
	155566074	175732	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-13	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	722	15	8	7	-1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4582914	175732	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-13	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	722	15	8	7	-1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL106959	208472	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-2	3	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)C(c1ccccc1)c1ccccc1	10.1021/jm010524p
	145989222	167278	None	0	Human	Functional	pEC50	=	6.4	6.4	-25	4	Agonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	676	17	7	6	2.2	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4293365	167278	None	0	Human	Functional	pEC50	=	6.4	6.4	-25	4	Agonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	676	17	7	6	2.2	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	44457002	97570	None	0	Mouse	Functional	pEC50	=	5.4	5.4	1	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	440	4	1	2	5.4	O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccc3ccccc3c2)c2cc(Cl)ccc21	10.1021/jm701303z
	CHEMBL270691	97570	None	0	Mouse	Functional	pEC50	=	5.4	5.4	1	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	440	4	1	2	5.4	O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccc3ccccc3c2)c2cc(Cl)ccc21	10.1021/jm701303z
	44577510	188733	None	0	Human	Functional	pEC50	=	7.4	7.4	-33	4	Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	893	12	11	11	0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL504986	188733	None	0	Human	Functional	pEC50	=	7.4	7.4	-33	4	Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	893	12	11	11	0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	164627532	186606	None	0	Mouse	Functional	pEC50	=	6.4	6.4	18	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	601	11	3	3	6.1	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4878922	186606	None	0	Mouse	Functional	pEC50	=	6.4	6.4	18	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	601	11	3	3	6.1	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	137657607	159634	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-81	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	844	15	7	6	2.4	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4103567	159634	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-81	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	844	15	7	6	2.4	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	122184576	122426	None	0	Human	Functional	pEC50	=	6.4	6.4	-32	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600837	122426	None	0	Human	Functional	pEC50	=	6.4	6.4	-32	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	44401313	12285	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	571	8	4	5	3.3	CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	CHEMBL1184856	12285	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	571	8	4	5	3.3	CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	CHEMBL2028956	12285	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	571	8	4	5	3.3	CC[C@@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	11273288	12958	None	0	Human	Functional	pEC50	=	6.4	6.4	-181	3	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	3	5	3.6	CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C	10.1016/j.bmcl.2005.02.068
	CHEMBL1189370	12958	None	0	Human	Functional	pEC50	=	6.4	6.4	-181	3	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	3	5	3.6	CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C	10.1016/j.bmcl.2005.02.068
	CHEMBL538567	12958	None	0	Human	Functional	pEC50	=	6.4	6.4	-181	3	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	585	8	3	5	3.6	CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C	10.1016/j.bmcl.2005.02.068
	CHEMBL410168	212802	None	0	Human	Functional	pEC50	=	6.4	6.4	-50	3	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	44448631	95068	None	0	Human	Functional	pEC50	=	6.3	6.3	-91	4	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL255286	95068	None	0	Human	Functional	pEC50	=	6.3	6.3	-91	4	Agonist activity at human MC5R expressed in CHO cells assesses as cAMP releaseAgonist activity at human MC5R expressed in CHO cells assesses as cAMP release	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	102096778	58804	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-5	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	51351277	58804	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-5	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	53322400	58804	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-5	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	91932360	58804	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-5	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	CHEMBL1688111	58804	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-5	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	CHEMBL2323794	209518	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-5	3	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	137638218	156826	None	0	Mouse	Functional	pEC50	=	7.3	7.3	2	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	988	11	11	10	-0.7	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4071283	156826	None	0	Mouse	Functional	pEC50	=	7.3	7.3	2	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	988	11	11	10	-0.7	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL2372365	210222	None	0	Mouse	Functional	pEC50	=	7.3	7.3	1	3	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC(C)(C)[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	44408189	168877	None	0	Human	Functional	pEC50	=	6.3	6.3	-32	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	619	8	2	4	4.6	CN1CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)C1=O	10.1016/j.bmcl.2005.11.095
	CHEMBL438259	168877	None	0	Human	Functional	pEC50	=	6.3	6.3	-32	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	619	8	2	4	4.6	CN1CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)C1=O	10.1016/j.bmcl.2005.11.095
	CHEMBL3600840	211815	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL2323798	209522	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-15	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCCN)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	CHEMBL2304248	209483	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-2	4	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	164614821	185266	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	608	12	3	3	6.9	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	CHEMBL4858724	185266	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	608	12	3	3	6.9	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	45487285	196991	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-7	2	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	627	15	9	7	0.6	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1ccc2cc(O)ccc2c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL566760	196991	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-7	2	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	627	15	9	7	0.6	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1ccc2cc(O)ccc2c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	168295131	192240	None	0	Human	Functional	pEC50	=	7.3	7.3	-7	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5205283	192240	None	0	Human	Functional	pEC50	=	7.3	7.3	-7	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC5R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	137654884	158595	None	0	Mouse	Functional	pEC50	=	7.3	7.3	3	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	840	9	10	9	-1.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4092082	158595	None	0	Mouse	Functional	pEC50	=	7.3	7.3	3	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	840	9	10	9	-1.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	44408252	140667	None	0	Human	Functional	pEC50	=	6.3	6.3	-30	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	605	8	3	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCNC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL381503	140667	None	0	Human	Functional	pEC50	=	6.3	6.3	-30	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	605	8	3	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCNC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	164621683	185591	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	606	12	3	3	6.8	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	CHEMBL4863711	185591	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	606	12	3	3	6.8	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	44441636	94010	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	520	9	2	4	4.8	CCCCC1(CC#N)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL248701	94010	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	520	9	2	4	4.8	CCCCC1(CC#N)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	46232227	199168	None	0	Mouse	Functional	pEC50	=	6.3	6.3	2	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	863	12	9	8	0.7	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL589517	199168	None	0	Mouse	Functional	pEC50	=	6.3	6.3	2	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	863	12	9	8	0.7	N=C(N)NCCC[C@@H]1NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL3349030	211403	None	0	Human	Functional	pEC50	=	7.3	7.3	-8	3	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	49862375	15037	None	0	Human	Functional	pEC50	=	6.3	6.3	-16	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	624	8	0	6	5.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cccnn1	10.1016/j.bmcl.2010.06.038
	CHEMBL1209318	15037	None	0	Human	Functional	pEC50	=	6.3	6.3	-16	4	Agonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	624	8	0	6	5.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cccnn1	10.1016/j.bmcl.2010.06.038
	164624386	186196	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	593	10	4	4	5.0	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4872932	186196	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	593	10	4	4	5.0	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL414778	213154	None	0	Human	Functional	pEC50	=	6.3	6.3	-83	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	1334	1500	None	7	Human	Functional	pEC50	=	6.3	6.3	-17	4	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	16133814	1500	None	7	Human	Functional	pEC50	=	6.3	6.3	-17	4	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	CHEMBL437050	1500	None	7	Human	Functional	pEC50	=	6.3	6.3	-17	4	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	71457994	78577	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-12	4	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	441	8	5	3	3.7	NCc1ccc(NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)cc1	10.1016/s0960-894x(03)00318-4
	CHEMBL2112213	78577	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-12	4	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	441	8	5	3	3.7	NCc1ccc(NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)cc1	10.1016/s0960-894x(03)00318-4
	44305770	202792	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-2	4	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	448	9	5	4	2.2	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCc2ccccc2C1	10.1016/s0960-894x(03)00318-4
	CHEMBL62228	202792	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-2	4	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	448	9	5	4	2.2	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCc2ccccc2C1	10.1016/s0960-894x(03)00318-4
	155542149	173090	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-2	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	740	17	8	6	1.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4520119	173090	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-2	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	740	17	8	6	1.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	155555182	174319	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-2	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	778	18	9	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4550582	174319	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-2	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	778	18	9	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	155563222	175289	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-16	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	711	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4572994	175289	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-16	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	711	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	118722929	116230	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-6	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	CHEMBL3358538	116230	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-6	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	CHEMBL3287329	211309	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-1	5	Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	CHEMBL503449	214164	None	0	Mouse	Functional	pEC50	=	8.3	8.3	1	4	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(C)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	118722925	116227	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-7	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL3358534	116227	None	0	Mouse	Functional	pEC50	=	8.3	8.3	-7	4	Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	122179552	121485	None	0	Mouse	Functional	pEC50	=	8.3	8.3	2	4	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL	699	19	10	7	0.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CC(N)=O)Cc1c[nH]c2ccccc12	10.1021/acsmedchemlett.5b00053
	CHEMBL3582446	121485	None	0	Mouse	Functional	pEC50	=	8.3	8.3	2	4	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL	699	19	10	7	0.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CC(N)=O)Cc1c[nH]c2ccccc12	10.1021/acsmedchemlett.5b00053
	162661397	181524	None	0	Mouse	Functional	pEC50	=	8.3	8.3	1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	725	17	8	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4765156	181524	None	0	Mouse	Functional	pEC50	=	8.3	8.3	1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	725	17	8	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	1323	2686	None	55	Human	Functional	pEC50	=	8.2	8.2	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	92432	2686	None	55	Human	Functional	pEC50	=	8.2	8.2	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.2	8.2	-181	8	Agonist activity at human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	162649653	180098	None	0	Mouse	Functional	pEC50	=	8.2	8.2	-9	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	753	18	10	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4748317	180098	None	0	Mouse	Functional	pEC50	=	8.2	8.2	-9	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	753	18	10	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	1323	2686	None	55	Human	Functional	pEC50	=	8.2	8.2	-181	8	Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterAntagonist activity at human MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL		None	None	None		None	10.1021/ml500436s
	92432	2686	None	55	Human	Functional	pEC50	=	8.2	8.2	-181	8	Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterAntagonist activity at human MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL		None	None	None		None	10.1021/ml500436s
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.2	8.2	-181	8	Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterAntagonist activity at human MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL		None	None	None		None	10.1021/ml500436s
	CHEMBL438294	213764	None	0	Human	Functional	pEC50	=	7.3	7.3	5	3	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	155547310	173609	None	0	Mouse	Functional	pEC50	=	7.3	7.3	6	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	750	17	7	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4533593	173609	None	0	Mouse	Functional	pEC50	=	7.3	7.3	6	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	750	17	7	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	155556954	174546	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-165	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	692	15	8	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4556149	174546	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-165	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	692	15	8	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	155560756	175083	None	0	Mouse	Functional	pEC50	=	7.3	7.3	5	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	756	14	6	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4568647	175083	None	0	Mouse	Functional	pEC50	=	7.3	7.3	5	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	756	14	6	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	132180599	156891	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4072129	156891	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-3	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	164618352	184645	None	0	Mouse	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	608	11	3	3	6.8	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4849626	184645	None	0	Mouse	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	608	11	3	3	6.8	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	137657385	159764	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	867	21	11	7	0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4105142	159764	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	867	21	11	7	0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL2112008	209224	None	0	Human	Functional	pEC50	=	5.3	5.3	-14	3	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL455826	214007	None	0	Mouse	Functional	pEC50	=	7.3	7.3	1	4	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cc2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL321870	211230	None	0	Mouse	Functional	pEC50	=	7.3	7.3	5	4	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	164627732	186492	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	598	10	3	3	7.0	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4877232	186492	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	598	10	3	3	7.0	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	10210972	12273	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	607	9	3	5	3.5	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN(CC(F)F)CCN2)CC1	10.1016/j.bmcl.2004.10.020
	CHEMBL1184771	12273	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	607	9	3	5	3.5	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN(CC(F)F)CCN2)CC1	10.1016/j.bmcl.2004.10.020
	CHEMBL2145454	12273	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	607	9	3	5	3.5	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN(CC(F)F)CCN2)CC1	10.1016/j.bmcl.2004.10.020
	46885711	8068	None	0	Human	Functional	pEC50	=	5.3	5.3	-169	3	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	504	3	1	3	5.4	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(Cl)cc1	10.1021/jm9017866
	CHEMBL1091150	8068	None	0	Human	Functional	pEC50	=	5.3	5.3	-169	3	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	504	3	1	3	5.4	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(Cl)cc1	10.1021/jm9017866
	CHEMBL2323785	209509	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-8	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	155568641	176095	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-87	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	654	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4591394	176095	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-87	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	654	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4299612	213592	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(N)=O	10.1021/acs.jmedchem.5b01894
	137634090	156297	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-3	6	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL	3980	69	56	64	-22.2	CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N3)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N2	10.1021/acs.jmedchem.8b00251
	CHEMBL4065418	156297	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-3	6	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL	3980	69	56	64	-22.2	CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N3)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N2	10.1021/acs.jmedchem.8b00251
	44441647	154688	None	0	Human	Functional	pEC50	=	6.3	6.3	-22	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	631	8	2	7	4.1	Cn1nnnc1CC1(c2ccc(Cl)cc2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL399714	154688	None	0	Human	Functional	pEC50	=	6.3	6.3	-22	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	631	8	2	7	4.1	Cn1nnnc1CC1(c2ccc(Cl)cc2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	164609537	184395	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	612	12	3	3	7.6	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	CHEMBL4845842	184395	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	612	12	3	3	7.6	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	164623182	185617	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	607	11	4	4	5.4	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4864094	185617	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	607	11	4	4	5.4	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	44359591	32073	None	0	Mouse	Functional	pEC50	=	6.3	6.3	1	3	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL	699	19	8	7	-0.2	CC(=O)N(CCc1c[nH]cn1)CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2003.08.078
	CHEMBL140847	32073	None	0	Mouse	Functional	pEC50	=	6.3	6.3	1	3	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL	699	19	8	7	-0.2	CC(=O)N(CCc1c[nH]cn1)CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2003.08.078
	44347219	16578	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	781	9	10	8	0.2	NNC(=O)[C@H]1CCCCNC(=O)CCC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	CHEMBL123938	16578	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL	781	9	10	8	0.2	NNC(=O)[C@H]1CCCCNC(=O)CCC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	44359580	32875	None	0	Mouse	Functional	pEC50	=	5.3	5.3	1	2	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL	713	20	5	7	0.4	CC(=O)N(CCc1c[nH]cn1)CC(=O)N(CC(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(N)=O)Cc1ccccc1	10.1016/j.bmcl.2003.08.078
	CHEMBL141497	32875	None	0	Mouse	Functional	pEC50	=	5.3	5.3	1	2	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL	713	20	5	7	0.4	CC(=O)N(CCc1c[nH]cn1)CC(=O)N(CC(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(N)=O)Cc1ccccc1	10.1016/j.bmcl.2003.08.078
	164621263	185480	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	598	11	3	3	7.2	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	CHEMBL4862172	185480	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	598	11	3	3	7.2	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	137657151	159554	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-11	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	888	18	8	7	3.4	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4102613	159554	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-11	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	888	18	8	7	3.4	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	155549385	173803	None	0	Mouse	Functional	pEC50	=	7.3	7.3	4	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	756	14	6	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4538225	173803	None	0	Mouse	Functional	pEC50	=	7.3	7.3	4	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	756	14	6	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	162662360	181469	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-5	2	Agonist activity at mouse MC5R by alphascreen cAMP assayAgonist activity at mouse MC5R by alphascreen cAMP assay	ChEMBL	948	11	9	10	-0.8	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4764556	181469	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-5	2	Agonist activity at mouse MC5R by alphascreen cAMP assayAgonist activity at mouse MC5R by alphascreen cAMP assay	ChEMBL	948	11	9	10	-0.8	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	1334	1500	None	7	Human	Functional	pEC50	=	6.3	6.3	-17	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16133814	1500	None	7	Human	Functional	pEC50	=	6.3	6.3	-17	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL437050	1500	None	7	Human	Functional	pEC50	=	6.3	6.3	-17	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL410795	212840	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	3	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	1334	1500	None	7	Human	Functional	pEC50	=	6.3	6.3	-17	4	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		None	10.1021/jm030119t
	16133814	1500	None	7	Human	Functional	pEC50	=	6.3	6.3	-17	4	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		None	10.1021/jm030119t
	CHEMBL437050	1500	None	7	Human	Functional	pEC50	=	6.3	6.3	-17	4	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		None	10.1021/jm030119t
	137657206	159669	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-2	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	914	19	8	7	3.9	CC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4103985	159669	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-2	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	914	19	8	7	3.9	CC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL421028	213260	None	0	Mouse	Functional	pEC50	=	5.3	5.3	1	2	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	CHEMBL138212	208750	None	0	Mouse	Functional	pEC50	=	7.3	7.3	8	3	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CCc1c[nH]c2ccccc12)CC(N)=O	10.1016/j.bmcl.2003.08.078
	145966716	164303	None	0	Human	Functional	pEC50	=	6.3	6.3	-138	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	887	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4212209	164303	None	0	Human	Functional	pEC50	=	6.3	6.3	-138	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	887	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	164613550	185127	None	0	Mouse	Functional	pEC50	=	6.3	6.3	12	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	606	11	3	3	6.7	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4856539	185127	None	0	Mouse	Functional	pEC50	=	6.3	6.3	12	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	606	11	3	3	6.7	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	164625589	185739	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	612	11	3	3	7.4	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4866151	185739	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	612	11	3	3	7.4	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	44445082	154300	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	2	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	799	9	10	8	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL398664	154300	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	2	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	799	9	10	8	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	137659091	159338	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-6	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	806	12	6	6	1.5	CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4100160	159338	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-6	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	806	12	6	6	1.5	CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	164615813	185142	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	594	10	3	3	6.4	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4856877	185142	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	594	10	3	3	6.4	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	164626394	186589	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	594	11	3	3	6.5	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	CHEMBL4878558	186589	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	594	11	3	3	6.5	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	1323	2686	None	55	Human	Functional	pEC50	=	8.2	8.2	-181	8	Agonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	92432	2686	None	55	Human	Functional	pEC50	=	8.2	8.2	-181	8	Agonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.2	8.2	-181	8	Agonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	CHEMBL2115441	209266	None	0	Human	Functional	pEC50	=	8.2	8.2	-64	4	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	CHEMBL195468	209100	None	0	Mouse	Functional	pEC50	=	8.2	8.2	-2	4	In vitro agonist potency for Mouse Melanocortin 5 receptorIn vitro agonist potency for Mouse Melanocortin 5 receptor	ChEMBL		None	None	None		CCCCCCCCCCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	16132144	209277	None	36	Mouse	Functional	pEC50	=	8.2	8.2	-1	8	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2009.07.025
	16133793	209277	None	36	Mouse	Functional	pEC50	=	8.2	8.2	-1	8	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2009.07.025
	44273719	209277	None	36	Mouse	Functional	pEC50	=	8.2	8.2	-1	8	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2009.07.025
	CHEMBL214332	209277	None	36	Mouse	Functional	pEC50	=	8.2	8.2	-1	8	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2009.07.025
	122184499	122391	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1088	17	13	11	0.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600737	122391	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1088	17	13	11	0.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	164609130	184425	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-3	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	595	10	4	4	5.1	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4846261	184425	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-3	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	595	10	4	4	5.1	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	164612768	184717	None	0	Mouse	Functional	pEC50	=	6.2	6.2	47	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	591	10	3	3	6.3	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4850501	184717	None	0	Mouse	Functional	pEC50	=	6.2	6.2	47	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	591	10	3	3	6.3	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	155561730	175651	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-19	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	684	14	7	6	-0.3	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4581269	175651	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-19	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	684	14	7	6	-0.3	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	137637251	155904	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-6	2	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	820	10	9	8	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4060767	155904	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-6	2	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	820	10	9	8	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL433296	213634	None	0	Mouse	Functional	pEC50	=	7.2	7.2	1	4	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	164622453	186088	None	0	Mouse	Functional	pEC50	=	6.2	6.2	2	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	601	12	3	3	6.2	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	CHEMBL4871577	186088	None	0	Mouse	Functional	pEC50	=	6.2	6.2	2	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	601	12	3	3	6.2	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	45487286	197339	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-10	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	631	16	8	8	-0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc2c(c1)OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL568940	197339	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-10	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	631	16	8	8	-0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc2c(c1)OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL3600922	211823	None	0	Human	Functional	pEC50	=	7.2	7.2	2	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	44408276	75505	None	0	Human	Functional	pEC50	=	6.2	6.2	-61	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	632	8	2	5	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL204308	75505	None	0	Human	Functional	pEC50	=	6.2	6.2	-61	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	632	8	2	5	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	45487298	197340	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-7	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	657	17	8	8	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/C=C/c1ccc2c(c1)OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL568965	197340	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-7	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	657	17	8	8	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/C=C/c1ccc2c(c1)OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL2323800	209524	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-39	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)[C@]23CCCN2C(=O)[C@@H](CSCC3=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	164617159	185433	None	0	Mouse	Functional	pEC50	=	6.2	6.2	11	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	545	13	4	4	4.7	CC(C)CCCN1C(=N)N([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C[C@H]1[C@@H](C)O	10.1021/acs.jmedchem.0c02041
	CHEMBL4861482	185433	None	0	Mouse	Functional	pEC50	=	6.2	6.2	11	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	545	13	4	4	4.7	CC(C)CCCN1C(=N)N([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2CC(C)C)C[C@H]1[C@@H](C)O	10.1021/acs.jmedchem.0c02041
	44441639	94048	None	0	Human	Functional	pEC50	=	6.2	6.2	-11	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	532	7	2	4	4.8	N#CCC1(C2CCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL248893	94048	None	0	Human	Functional	pEC50	=	6.2	6.2	-11	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	532	7	2	4	4.8	N#CCC1(C2CCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL105113	208464	None	0	Mouse	Functional	pEC50	=	6.2	6.2	1	4	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	137662147	159377	None	0	Human	Functional	pEC50	=	6.2	6.2	-99	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1051	19	15	15	-3.0	C[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4100598	159377	None	0	Human	Functional	pEC50	=	6.2	6.2	-99	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1051	19	15	15	-3.0	C[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	45487409	196895	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-9	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	621	16	8	6	0.8	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(Cl)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL566162	196895	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-9	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	621	16	8	6	0.8	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(Cl)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	44441633	94528	None	0	Human	Functional	pEC50	=	6.2	6.2	-18	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	546	7	2	4	5.2	N#CCC1(C2CCCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL251735	94528	None	0	Human	Functional	pEC50	=	6.2	6.2	-18	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	546	7	2	4	5.2	N#CCC1(C2CCCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	46885907	8038	None	0	Human	Functional	pEC50	=	5.2	5.2	-104	2	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	460	4	1	3	4.1	CCN1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3cccc(F)c3)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1	10.1021/jm9017866
	CHEMBL1090885	8038	None	0	Human	Functional	pEC50	=	5.2	5.2	-104	2	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	460	4	1	3	4.1	CCN1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3cccc(F)c3)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1	10.1021/jm9017866
	44408173	75399	None	0	Human	Functional	pEC50	=	6.2	6.2	-154	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	640	8	2	5	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCCS2(=O)=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL203975	75399	None	0	Human	Functional	pEC50	=	6.2	6.2	-154	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	640	8	2	5	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCCS2(=O)=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	164621924	185949	None	0	Mouse	Functional	pEC50	=	6.2	6.2	6	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	587	10	3	3	5.7	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4869531	185949	None	0	Mouse	Functional	pEC50	=	6.2	6.2	6	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	587	10	3	3	5.7	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	164627491	186501	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-3	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	587	11	3	3	5.8	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	CHEMBL4877442	186501	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-3	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	587	11	3	3	5.8	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	44441642	154403	None	0	Human	Functional	pEC50	=	6.2	6.2	-75	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	577	9	2	7	3.5	CC(C)CC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL398816	154403	None	0	Human	Functional	pEC50	=	6.2	6.2	-75	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	577	9	2	7	3.5	CC(C)CC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	45487418	197239	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-8	2	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	632	17	8	8	0.0	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc([N+](=O)[O-])cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL568341	197239	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-8	2	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	632	17	8	8	0.0	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc([N+](=O)[O-])cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL227239	209449	None	0	Human	Functional	pEC50	=	6.2	6.2	1	3	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2cc3ccccc3s2)N(CC)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	137646086	157892	None	0	Mouse	Functional	pEC50	=	4.2	4.2	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	908	19	8	6	3.8	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4084136	157892	None	0	Mouse	Functional	pEC50	=	4.2	4.2	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	908	19	8	6	3.8	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	45487410	197436	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-21	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	655	16	8	6	1.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(C(F)(F)F)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569696	197436	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-21	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	655	16	8	6	1.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(C(F)(F)F)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	137642664	158078	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-7	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	772	18	9	7	-0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4086346	158078	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-7	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	772	18	9	7	-0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL320157	211224	None	0	Mouse	Functional	pEC50	=	6.2	6.2	1	4	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	137641005	157037	None	0	Mouse	Functional	pEC50	=	4.2	4.2	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	858	19	8	6	2.7	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4073782	157037	None	0	Mouse	Functional	pEC50	=	4.2	4.2	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	858	19	8	6	2.7	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	45487297	197099	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-13	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	613	17	8	6	0.7	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/C=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL567634	197099	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-13	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	613	17	8	6	0.7	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/C=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	44441645	94125	None	0	Human	Functional	pEC50	=	6.2	6.2	-63	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	605	12	2	7	4.4	CCCCCCC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL249277	94125	None	0	Human	Functional	pEC50	=	6.2	6.2	-63	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	605	12	2	7	4.4	CCCCCCC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	45487406	196892	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-6	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	605	16	8	6	0.3	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccccc1F)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL566150	196892	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-6	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	605	16	8	6	0.3	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccccc1F)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL65339	215858	None	0	Mouse	Functional	pEC50	=	5.2	5.2	1	3	Functional activity at the mouse melanocortin 5 receptorFunctional activity at the mouse melanocortin 5 receptor	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	CHEMBL2372570	210269	None	0	Human	Functional	pEC50	=	7.2	7.2	-691	4	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC2=NC=NC2)NC1=O	10.1021/jm9017866
	CHEMBL2323788	209512	None	0	Mouse	Functional	pEC50	=	6.2	6.2	-13	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	45487414	197279	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-6	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	621	16	8	6	0.8	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(Cl)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL568577	197279	None	0	Mouse	Functional	pEC50	=	5.2	5.2	-6	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	621	16	8	6	0.8	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(Cl)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	137644603	158148	None	0	Mouse	Functional	pEC50	=	4.2	4.2	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	848	19	9	7	1.4	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4087277	158148	None	0	Mouse	Functional	pEC50	=	4.2	4.2	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	848	19	9	7	1.4	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL322889	211233	None	0	Mouse	Functional	pEC50	=	5.2	5.2	3	2	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	CHEMBL3600736	211810	None	0	Human	Functional	pEC50	=	8.2	8.2	-2	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	15602927	157880	None	0	Mouse	Functional	pEC50	=	8.2	8.2	-1	5	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL	835	12	10	8	-0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL408398	157880	None	0	Mouse	Functional	pEC50	=	8.2	8.2	-1	5	Agonist activity at mouse MC5R expressed in HEK293 cellsAgonist activity at mouse MC5R expressed in HEK293 cells	ChEMBL	835	12	10	8	-0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL322610	211232	None	0	Mouse	Functional	pEC50	=	8.1	8.1	2	4	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL501394	214135	None	0	Mouse	Functional	pEC50	=	8.1	8.1	-2	3	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	162672755	183088	None	0	Mouse	Functional	pEC50	=	8.1	8.1	-16	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4794484	183088	None	0	Mouse	Functional	pEC50	=	8.1	8.1	-16	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL50056	214117	None	2	Mouse	Functional	pEC50	=	7.2	7.2	-8	7	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.5b00053
	137658252	159627	None	0	Mouse	Functional	pEC50	=	7.2	7.2	6	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	868	10	10	9	-1.5	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4103508	159627	None	0	Mouse	Functional	pEC50	=	7.2	7.2	6	3	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	868	10	10	9	-1.5	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	45487290	196778	None	0	Mouse	Functional	pEC50	=	4.2	4.2	-22	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	579	17	9	7	-1.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1c[nH]cn1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL565474	196778	None	0	Mouse	Functional	pEC50	=	4.2	4.2	-22	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	579	17	9	7	-1.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1c[nH]cn1)C(N)=O	10.1016/j.bmcl.2009.07.025
	44401520	13928	None	0	Human	Functional	pEC50	=	6.2	6.2	-181	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	571	8	4	5	3.3	CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	CHEMBL1196472	13928	None	0	Human	Functional	pEC50	=	6.2	6.2	-181	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	571	8	4	5	3.3	CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	CHEMBL557154	13928	None	0	Human	Functional	pEC50	=	6.2	6.2	-181	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	571	8	4	5	3.3	CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	137661461	159374	None	0	Mouse	Functional	pEC50	=	4.2	4.2	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	870	16	7	6	2.9	CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4100584	159374	None	0	Mouse	Functional	pEC50	=	4.2	4.2	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	870	16	7	6	2.9	CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	51351151	58803	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-2	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	53318437	58803	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-2	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	91932359	58803	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-2	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL1688110	58803	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-2	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	137632394	156277	None	0	Mouse	Functional	pEC50	=	4.1	4.1	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	914	19	8	7	3.9	CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4065189	156277	None	0	Mouse	Functional	pEC50	=	4.1	4.1	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	914	19	8	7	3.9	CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	145948912	167483	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	4	Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL	1170	17	14	11	0.7	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL4299454	167483	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	4	Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL	1170	17	14	11	0.7	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	122179551	121484	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-1	4	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL	699	19	10	7	0.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.5b00053
	CHEMBL3582445	121484	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-1	4	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL	699	19	10	7	0.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.5b00053
	CHEMBL2370533	209866	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL		None	None	None		CC(=O)N[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm010165y
	CHEMBL105113	208464	None	0	Mouse	Functional	pEC50	=	6.1	6.1	1	4	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	1338	3805	None	43	Human	Functional	pEC50	=	6.1	6.1	-660	8	Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	9938402	3805	None	43	Human	Functional	pEC50	=	6.1	6.1	-660	8	Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	CHEMBL339053	3805	None	43	Human	Functional	pEC50	=	6.1	6.1	-660	8	Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	1338	3805	None	43	Human	Functional	pEC50	=	6.1	6.1	-660	8	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	9938402	3805	None	43	Human	Functional	pEC50	=	6.1	6.1	-660	8	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	CHEMBL339053	3805	None	43	Human	Functional	pEC50	=	6.1	6.1	-660	8	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	1338	3805	None	43	Human	Functional	pEC50	=	6.1	6.1	-660	8	Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC5R) receptorFunctional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC5R) receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	9938402	3805	None	43	Human	Functional	pEC50	=	6.1	6.1	-660	8	Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC5R) receptorFunctional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC5R) receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	CHEMBL339053	3805	None	43	Human	Functional	pEC50	=	6.1	6.1	-660	8	Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC5R) receptorFunctional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC5R) receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	44359589	31477	None	0	Mouse	Functional	pEC50	=	5.1	5.1	3	3	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL	685	20	4	7	1.4	CC(=O)N(CCc1c[nH]cn1)CC(=O)N(CC(=O)N(CCCCN)CC(=O)N(CCc1c[nH]c2ccccc12)CC(N)=O)Cc1ccccc1	10.1016/j.bmcl.2003.08.078
	CHEMBL140324	31477	None	0	Mouse	Functional	pEC50	=	5.1	5.1	3	3	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	ChEMBL	685	20	4	7	1.4	CC(=O)N(CCc1c[nH]cn1)CC(=O)N(CC(=O)N(CCCCN)CC(=O)N(CCc1c[nH]c2ccccc12)CC(N)=O)Cc1ccccc1	10.1016/j.bmcl.2003.08.078
	CHEMBL438235	213757	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	3	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)CSSC1(C)C	10.1021/jm030119t
	164621414	185772	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	531	12	4	4	4.4	CC(C)CCCN1C(=N)N([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C[C@H]1[C@@H](C)O	10.1021/acs.jmedchem.0c02041
	CHEMBL4866532	185772	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-1	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	531	12	4	4	4.4	CC(C)CCCN1C(=N)N([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C[C@H]1[C@@H](C)O	10.1021/acs.jmedchem.0c02041
	CHEMBL104397	208461	None	0	Mouse	Functional	pEC50	=	5.1	5.1	2	2	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	155562846	175168	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-6	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	564	13	5	6	-0.2	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4570356	175168	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-6	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	564	13	5	6	-0.2	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	137656521	159742	None	0	Human	Functional	pEC50	=	6.1	6.1	-33	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1139	22	17	16	-3.1	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4104927	159742	None	0	Human	Functional	pEC50	=	6.1	6.1	-33	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1139	22	17	16	-3.1	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	44401524	14004	None	0	Human	Functional	pEC50	=	6.1	6.1	-120	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	583	8	4	5	3.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@@H](C3CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL1197052	14004	None	0	Human	Functional	pEC50	=	6.1	6.1	-120	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	583	8	4	5	3.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@@H](C3CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL559181	14004	None	0	Human	Functional	pEC50	=	6.1	6.1	-120	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	583	8	4	5	3.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@@H](C3CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL227833	209450	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	CHEMBL3349030	211403	None	0	Human	Functional	pEC50	=	6.1	6.1	-8	3	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL2323792	209516	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-1	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	127047336	139796	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-74	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1730	54	21	19	1.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3798768	139796	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-74	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1730	54	21	19	1.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	10122170	130317	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	2	Effective concentration determined against melanocortin-5 receptorEffective concentration determined against melanocortin-5 receptor	ChEMBL	638	10	3	7	2.2	CS(=O)(=O)N(CCN)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.01.060
	CHEMBL368008	130317	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	2	Effective concentration determined against melanocortin-5 receptorEffective concentration determined against melanocortin-5 receptor	ChEMBL	638	10	3	7	2.2	CS(=O)(=O)N(CCN)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.01.060
	1323	2686	None	55	Human	Functional	pEC50	=	8.1	8.1	-181	8	Activity at human MC5R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulationActivity at human MC5R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	92432	2686	None	55	Human	Functional	pEC50	=	8.1	8.1	-181	8	Activity at human MC5R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulationActivity at human MC5R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	CHEMBL430239	2686	None	55	Human	Functional	pEC50	=	8.1	8.1	-181	8	Activity at human MC5R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulationActivity at human MC5R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	155556466	174414	None	0	Mouse	Functional	pEC50	=	8.1	8.1	-11	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	648	17	8	6	1.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4552764	174414	None	0	Mouse	Functional	pEC50	=	8.1	8.1	-11	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	648	17	8	6	1.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL501679	214141	None	0	Mouse	Functional	pEC50	=	8.1	8.1	1	3	Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	46232226	201081	None	0	Mouse	Functional	pEC50	=	8.1	8.1	6	4	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	863	12	9	8	0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL602853	201081	None	0	Mouse	Functional	pEC50	=	8.1	8.1	6	4	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	863	12	9	8	0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL589308	215797	None	0	Mouse	Functional	pEC50	=	8.1	8.1	1	3	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)NCC(=O)N(CC(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)Cc1ccccc1)Cc1ccccc1	10.1016/j.bmc.2009.12.010
	16132144	209277	None	36	Human	Functional	pEC50	=	8.1	8.1	-81	8	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	16133793	209277	None	36	Human	Functional	pEC50	=	8.1	8.1	-81	8	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	44273719	209277	None	36	Human	Functional	pEC50	=	8.1	8.1	-81	8	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	CHEMBL214332	209277	None	36	Human	Functional	pEC50	=	8.1	8.1	-81	8	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	16132144	209277	None	36	Human	Functional	pEC50	=	8.1	8.1	-81	8	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	16133793	209277	None	36	Human	Functional	pEC50	=	8.1	8.1	-81	8	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	44273719	209277	None	36	Human	Functional	pEC50	=	8.1	8.1	-81	8	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	CHEMBL214332	209277	None	36	Human	Functional	pEC50	=	8.1	8.1	-81	8	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	CHEMBL415200	213177	None	0	Mouse	Functional	pEC50	=	8.1	8.1	5	5	Maximum agonist response for mouse melanocortin 5 receptor (MC5R)Maximum agonist response for mouse melanocortin 5 receptor (MC5R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(CCCN)CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	132180598	157847	None	0	Mouse	Functional	pEC50	=	8.1	8.1	-16	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	803	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4083717	157847	None	0	Mouse	Functional	pEC50	=	8.1	8.1	-16	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	803	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	155562237	175707	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-39	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	692	15	8	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4582276	175707	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-39	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	692	15	8	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	44408155	140551	None	0	Human	Functional	pEC50	=	6.1	6.1	-114	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	656	10	2	5	4.9	CC(C)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O	10.1016/j.bmcl.2005.11.095
	CHEMBL381125	140551	None	0	Human	Functional	pEC50	=	6.1	6.1	-114	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	656	10	2	5	4.9	CC(C)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O	10.1016/j.bmcl.2005.11.095
	164622957	186112	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4871777	186112	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164627764	186562	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	603	11	4	4	4.8	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4878201	186562	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	603	11	4	4	4.8	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL3349030	211403	None	0	Human	Functional	pEC50	=	6.1	6.1	-8	3	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	122184912	122556	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601430	122556	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL376339	212242	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	16157270	212551	None	14	Human	Functional	pEC50	=	7.1	7.1	-109	7	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	CHEMBL405282	212551	None	14	Human	Functional	pEC50	=	7.1	7.1	-109	7	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	CHEMBL411359	212877	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	4	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	16157270	212551	None	14	Human	Functional	pEC50	=	7.1	7.1	-109	7	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL405282	212551	None	14	Human	Functional	pEC50	=	7.1	7.1	-109	7	Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorEffective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	155551195	173940	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-38	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	626	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4541098	173940	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-38	4	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	626	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	44305956	102759	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-2	4	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	490	11	5	4	2.9	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NC1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	CHEMBL305132	102759	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-2	4	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	490	11	5	4	2.9	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NC1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	44305784	203337	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-1	3	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	447	8	4	3	3.4	CC1CCN(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	CHEMBL64967	203337	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-1	3	Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsAgonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	ChEMBL	447	8	4	3	3.4	CC1CCN(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	CHEMBL2323787	209511	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-41	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	137635701	156035	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	908	19	8	6	3.8	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4062425	156035	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	908	19	8	6	3.8	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL3600921	211822	None	0	Human	Functional	pEC50	=	6.1	6.1	-6	4	Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	44391929	12410	None	0	Human	Functional	pEC50	=	6.1	6.1	-25	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	571	8	3	5	3.3	CCN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL1185810	12410	None	0	Human	Functional	pEC50	=	6.1	6.1	-25	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	571	8	3	5	3.3	CCN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL2145453	12410	None	0	Human	Functional	pEC50	=	6.1	6.1	-25	2	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	ChEMBL	571	8	3	5	3.3	CCN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL502300	214150	None	0	Human	Functional	pEC50	=	7.1	7.1	-6	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	CHEMBL381739	212290	None	0	Human	Functional	pEC50	=	6.1	6.1	4	3	Activity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	10.1021/jm0510326
	44408154	141360	None	0	Human	Functional	pEC50	=	6.1	6.1	-218	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	668	8	2	5	5.1	CC1(C)CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)S1(=O)=O	10.1016/j.bmcl.2005.11.095
	CHEMBL383719	141360	None	0	Human	Functional	pEC50	=	6.1	6.1	-218	4	Activity against human MC5R by cAMP accumulationActivity against human MC5R by cAMP accumulation	ChEMBL	668	8	2	5	5.1	CC1(C)CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)S1(=O)=O	10.1016/j.bmcl.2005.11.095
	CHEMBL2323797	209521	None	0	Mouse	Functional	pEC50	=	6.1	6.1	-44	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@H]1CN2C(=O)CSC[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)CSSC[C@@H](C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm301253y
	1337	3422	None	6	Human	Functional	pEC50	=	6.1	6.1	-3	5	Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL	582	7	2	4	4.7	O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F	10.1016/j.bmcl.2005.05.109
	6918851	3422	None	6	Human	Functional	pEC50	=	6.1	6.1	-3	5	Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL	582	7	2	4	4.7	O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F	10.1016/j.bmcl.2005.05.109
	CHEMBL364346	3422	None	6	Human	Functional	pEC50	=	6.1	6.1	-3	5	Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL	582	7	2	4	4.7	O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F	10.1016/j.bmcl.2005.05.109
	10188529	126779	None	0	Human	Functional	pEC50	=	6.1	6.1	-34	3	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL	582	7	2	4	4.7	CN1C[C@H]2CC[C@@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2	10.1016/j.bmcl.2005.05.109
	CHEMBL365401	126779	None	0	Human	Functional	pEC50	=	6.1	6.1	-34	3	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL	582	7	2	4	4.7	CN1C[C@H]2CC[C@@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2	10.1016/j.bmcl.2005.05.109
	45487292	196850	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-4	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	628	16	9	8	-0.3	N#C/C(=C\c1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL565900	196850	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-4	3	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	628	16	9	8	-0.3	N#C/C(=C\c1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL2323796	209520	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-79	3	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	24882615	97490	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	371	6	2	3	3.1	NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O	10.1021/jm701303z
	CHEMBL270270	97490	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-1	4	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	371	6	2	3	3.1	NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O	10.1021/jm701303z
	CHEMBL331259	211359	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm010165y
	CHEMBL408509	212718	None	0	Human	Functional	pEC50	=	6.1	6.1	2	3	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	44401310	12783	None	0	Human	Functional	pEC50	=	6.1	6.1	-125	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	557	7	4	5	2.9	C[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	CHEMBL1188043	12783	None	0	Human	Functional	pEC50	=	6.1	6.1	-125	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	557	7	4	5	2.9	C[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	CHEMBL534930	12783	None	0	Human	Functional	pEC50	=	6.1	6.1	-125	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	557	7	4	5	2.9	C[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1	10.1016/j.bmcl.2005.02.068
	71456219	78745	None	0	Human	Functional	pEC50	=	6.1	6.1	-23	3	Effective concentration of peptide at 50% maximal cAMP generation (10e-10 to 10e-4 M)Effective concentration of peptide at 50% maximal cAMP generation (10e-10 to 10e-4 M)	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL2112603	78745	None	0	Human	Functional	pEC50	=	6.1	6.1	-23	3	Effective concentration of peptide at 50% maximal cAMP generation (10e-10 to 10e-4 M)Effective concentration of peptide at 50% maximal cAMP generation (10e-10 to 10e-4 M)	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	44441684	94129	None	0	Human	Functional	pEC50	=	6.1	6.1	-109	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	571	7	3	5	3.1	CC1CCC(C2(C(=O)NC(C)(C)C)CCN(C(=O)[C@H](Cc3ccc(F)cc3)NC(=O)[C@H]3CN(C)CCN3)CC2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL249321	94129	None	0	Human	Functional	pEC50	=	6.1	6.1	-109	3	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	571	7	3	5	3.1	CC1CCC(C2(C(=O)NC(C)(C)C)CCN(C(=O)[C@H](Cc3ccc(F)cc3)NC(=O)[C@H]3CN(C)CCN3)CC2)CC1	10.1016/j.bmcl.2006.11.084
	162672755	183088	None	0	Mouse	Functional	pEC50	=	8.1	8.1	-16	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4794484	183088	None	0	Mouse	Functional	pEC50	=	8.1	8.1	-16	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL2323795	209519	None	0	Mouse	Functional	pEC50	=	8.0	8.0	-19	4	Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	CHEMBL264190	210606	None	1	Mouse	Functional	pEC50	=	8.0	8.0	2	8	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL2369485	209626	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-1	4	Effective concentration against mouse Melanocortin 5 receptorEffective concentration against mouse Melanocortin 5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NN[C@H]2Cc3ccc(O)cc3NC2=O)CC(=O)N[C@H](C(=O)NN[C@@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	155549302	173801	None	0	Mouse	Functional	pEC50	=	7.1	7.1	1	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	626	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4538209	173801	None	0	Mouse	Functional	pEC50	=	7.1	7.1	1	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	626	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	155554827	174617	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-2	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	621	16	8	7	-1.6	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4557656	174617	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-2	3	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	621	16	8	7	-1.6	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	155562993	175229	None	0	Mouse	Functional	pEC50	=	5.1	5.1	1	2	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	694	14	6	7	-1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4571760	175229	None	0	Mouse	Functional	pEC50	=	5.1	5.1	1	2	Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayFull agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	694	14	6	7	-1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	137637026	155923	None	0	Human	Functional	pEC50	=	6.0	6.0	-162	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1052	20	15	14	-1.4	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4060937	155923	None	0	Human	Functional	pEC50	=	6.0	6.0	-162	3	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1052	20	15	14	-1.4	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	44401321	11794	None	0	Human	Functional	pEC50	=	6.0	6.0	-19	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	597	8	4	5	3.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C3(C)CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL1181867	11794	None	0	Human	Functional	pEC50	=	6.0	6.0	-19	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	597	8	4	5	3.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C3(C)CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	CHEMBL2028960	11794	None	0	Human	Functional	pEC50	=	6.0	6.0	-19	2	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor	ChEMBL	597	8	4	5	3.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2CN[C@H](C3(C)CC3)CN2)CC1	10.1016/j.bmcl.2005.02.068
	102096778	58804	None	0	Mouse	Functional	pEC50	=	6.0	6.0	-5	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	51351277	58804	None	0	Mouse	Functional	pEC50	=	6.0	6.0	-5	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	53322400	58804	None	0	Mouse	Functional	pEC50	=	6.0	6.0	-5	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	91932360	58804	None	0	Mouse	Functional	pEC50	=	6.0	6.0	-5	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL1688111	58804	None	0	Mouse	Functional	pEC50	=	6.0	6.0	-5	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	45487415	197437	None	0	Mouse	Functional	pEC50	=	6.0	6.0	-11	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	603	16	9	7	-0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(O)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569697	197437	None	0	Mouse	Functional	pEC50	=	6.0	6.0	-11	4	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	603	16	9	7	-0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(O)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	164625186	185965	None	0	Mouse	Functional	pEC50	=	6.0	6.0	2	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	591	11	3	3	6.5	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	CHEMBL4869669	185965	None	0	Mouse	Functional	pEC50	=	6.0	6.0	2	3	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	591	11	3	3	6.5	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	145973975	164655	None	0	Human	Functional	pEC50	=	7.0	7.0	-22	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4216654	164655	None	0	Human	Functional	pEC50	=	7.0	7.0	-22	4	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	46885480	7752	None	0	Human	Functional	pEC50	=	6.0	6.0	-63	3	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	491	4	1	4	4.6	C[C@H]1CN(C(=O)[C@H]2CN(c3ccccn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1089103	7752	None	0	Human	Functional	pEC50	=	6.0	6.0	-63	3	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayAgonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	ChEMBL	491	4	1	4	4.6	C[C@H]1CN(C(=O)[C@H]2CN(c3ccccn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	45487412	196821	None	0	Mouse	Functional	pEC50	=	5.0	5.0	-8	2	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	605	17	9	7	-0.3	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccc(O)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL565740	196821	None	0	Mouse	Functional	pEC50	=	5.0	5.0	-8	2	Agonistic activity against mouse MC5RAgonistic activity against mouse MC5R	ChEMBL	605	17	9	7	-0.3	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccc(O)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL430489	213618	None	0	Mouse	Functional	pEC50	=	5.0	5.0	2	3	Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	44441681	94127	None	0	Human	Functional	pEC50	=	6.0	6.0	-104	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	557	7	3	5	2.9	CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2006.11.084
	CHEMBL249319	94127	None	0	Human	Functional	pEC50	=	6.0	6.0	-104	2	Antagonist activity at human MC5R assessed as stimulation of cAMP productionAntagonist activity at human MC5R assessed as stimulation of cAMP production	ChEMBL	557	7	3	5	2.9	CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2006.11.084
	CHEMBL439691	213846	None	0	Human	Functional	pEC50	=	7	7.0	-16	3	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL438030	213742	None	0	Human	Functional	pEC50	=	7	7.0	-63	3	Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	51351024	58800	None	0	Mouse	Functional	pEC50	=	6	6.0	-4	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	53318435	58800	None	0	Mouse	Functional	pEC50	=	6	6.0	-4	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	91932358	58800	None	0	Mouse	Functional	pEC50	=	6	6.0	-4	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL1688106	58800	None	0	Mouse	Functional	pEC50	=	6	6.0	-4	4	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	168277916	190675	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	4986	94	68	63	-6.6	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCNC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5181812	190675	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	4986	94	68	63	-6.6	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCNC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168290510	191895	None	0	Human	Functional	pIC50	=	5.0	5.0	-1288	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1215	15	14	15	-1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5199932	191895	None	0	Human	Functional	pIC50	=	5.0	5.0	-1288	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1215	15	14	15	-1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	168293710	192164	None	0	Human	Functional	pIC50	=	6.9	6.9	-1288	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccc(cc3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5203986	192164	None	0	Human	Functional	pIC50	=	6.9	6.9	-1288	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccc(cc3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168278271	191113	None	0	Human	Functional	pIC50	=	5.9	5.9	-2818	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2167	35	34	26	-5.3	CCCC[C@@H]1NC(=O)[C@@H]2CS/C(C(=O)O)=C(/C(N)=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5187932	191113	None	0	Human	Functional	pIC50	=	5.9	5.9	-2818	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2167	35	34	26	-5.3	CCCC[C@@H]1NC(=O)[C@@H]2CS/C(C(=O)O)=C(/C(N)=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168276507	190263	None	0	Human	Functional	pIC50	=	6.9	6.9	-1584	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3cccc(c3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5175487	190263	None	0	Human	Functional	pIC50	=	6.9	6.9	-1584	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3cccc(c3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168285101	191642	None	0	Human	Functional	pIC50	=	4.8	4.8	-7079	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccccc2CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5195937	191642	None	0	Human	Functional	pIC50	=	4.8	4.8	-7079	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccccc2CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	168273645	190323	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	5162	106	68	67	-6.5	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCOCCOCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5176443	190323	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	5162	106	68	67	-6.5	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCOCCOCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168271237	190486	None	0	Human	Functional	pIC50	=	5.8	5.8	-6760	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2788	45	36	36	0.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5179081	190486	None	0	Human	Functional	pIC50	=	5.8	5.8	-6760	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2788	45	36	36	0.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168285904	191668	None	0	Human	Functional	pIC50	=	4.8	4.8	-10232	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2cccc(c2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5196407	191668	None	0	Human	Functional	pIC50	=	4.8	4.8	-10232	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2cccc(c2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	168294114	192188	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	4756	82	66	59	-5.7	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5204285	192188	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	4756	82	66	59	-5.7	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168274920	190261	None	0	Human	Functional	pIC50	=	4.8	4.8	-6025	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5175444	190261	None	0	Human	Functional	pIC50	=	4.8	4.8	-6025	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	168283616	191237	None	0	Human	Functional	pIC50	=	6.7	6.7	-331	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2110	33	32	25	-4.5	CCCC[C@@H]1NC(=O)[C@@H]2CSCC(=O)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5190042	191237	None	0	Human	Functional	pIC50	=	6.7	6.7	-331	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2110	33	32	25	-4.5	CCCC[C@@H]1NC(=O)[C@@H]2CSCC(=O)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	11993702	3591	None	18	Human	Functional	pIC50	=	5.7	5.7	-12589	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	5416	3591	None	18	Human	Functional	pIC50	=	5.7	5.7	-12589	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	9272	3591	None	18	Human	Functional	pIC50	=	5.7	5.7	-12589	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	CHEMBL3301624	3591	None	18	Human	Functional	pIC50	=	5.7	5.7	-12589	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	DB11700	3591	None	18	Human	Functional	pIC50	=	5.7	5.7	-12589	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	168272660	190431	None	0	Human	Functional	pIC50	=	6.7	6.7	-1548	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2202	33	32	24	-2.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3c(F)c(F)c(c(F)c3F)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5178164	190431	None	0	Human	Functional	pIC50	=	6.7	6.7	-1548	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2202	33	32	24	-2.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3c(F)c(F)c(c(F)c3F)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168277543	190673	None	0	Human	Functional	pIC50	=	4.7	4.7	-4897	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccc(cc2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5181752	190673	None	0	Human	Functional	pIC50	=	4.7	4.7	-4897	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccc(cc2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	10408	719	None	28	Human	Functional	pIC50	=	6.7	6.7	-467	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	5329	719	None	28	Human	Functional	pIC50	=	6.7	6.7	-467	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	9941379	719	None	28	Human	Functional	pIC50	=	6.7	6.7	-467	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	CHEMBL2070241	719	None	28	Human	Functional	pIC50	=	6.7	6.7	-467	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	DB11653	719	None	28	Human	Functional	pIC50	=	6.7	6.7	-467	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	168289457	191378	None	0	Human	Functional	pIC50	=	6.7	6.7	-1047	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccccc3CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5192329	191378	None	0	Human	Functional	pIC50	=	6.7	6.7	-1047	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccccc3CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168272615	190385	None	0	Human	Functional	pIC50	=	4.7	4.7	-4073	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5177494	190385	None	0	Human	Functional	pIC50	=	4.7	4.7	-4073	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	168284256	190944	None	0	Human	Functional	pIC50	=	6.7	6.7	-4570	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2383	48	33	31	-4.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC/C(=N/OCC(=O)NCCOCCOCCOCCN=[N+]=[N-])CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5185775	190944	None	0	Human	Functional	pIC50	=	6.7	6.7	-4570	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2383	48	33	31	-4.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC/C(=N/OCC(=O)NCCOCCOCCOCCN=[N+]=[N-])CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168271934	190083	None	0	Human	Functional	pIC50	=	7.6	7.6	-288	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2229	37	32	26	-3.7	C#CCCCCN1C(=O)C2=C(SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC3=O)C1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5172738	190083	None	0	Human	Functional	pIC50	=	7.6	7.6	-288	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2229	37	32	26	-3.7	C#CCCCCN1C(=O)C2=C(SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC3=O)C1=O	10.1021/acs.jmedchem.2c00793
	168296647	192473	None	0	Human	Functional	pIC50	=	4.6	4.6	-13489	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccccc2CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5208830	192473	None	0	Human	Functional	pIC50	=	4.6	4.6	-13489	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccccc2CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	168270124	189953	None	0	Human	Functional	pIC50	=	6.6	6.6	-1819	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2096	33	32	24	-3.6	CCCC[C@@H]1NC(=O)[C@@H]2CSCCCSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5170533	189953	None	0	Human	Functional	pIC50	=	6.6	6.6	-1819	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2096	33	32	24	-3.6	CCCC[C@@H]1NC(=O)[C@@H]2CSCCCSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	1323	2686	None	55	Human	Functional	pIC50	=	7.6	7.6	-181	8	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	92432	2686	None	55	Human	Functional	pIC50	=	7.6	7.6	-181	8	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	CHEMBL430239	2686	None	55	Human	Functional	pIC50	=	7.6	7.6	-181	8	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	168276294	190506	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	3264	55	36	40	1.5	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCNC(=O)OCC3C4CCc5nnn(CC(=O)N6CCCC[C@H]6C6(O)CN(C(=O)c7ccc(F)c(F)c7Nc7ccc(I)cc7F)C6)c5CCC43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5179373	190506	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	3264	55	36	40	1.5	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCNC(=O)OCC3C4CCc5nnn(CC(=O)N6CCCC[C@H]6C6(O)CN(C(=O)c7ccc(F)c(F)c7Nc7ccc(I)cc7F)C6)c5CCC43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168284733	191622	None	0	Human	Functional	pIC50	=	7.4	7.4	-162	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2054	33	32	24	-4.1	CCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5195641	191622	None	0	Human	Functional	pIC50	=	7.4	7.4	-162	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2054	33	32	24	-4.1	CCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168289404	191310	None	0	Human	Functional	pIC50	=	7.4	7.4	-933	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2134	33	32	28	-5.0	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(nn3)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5191309	191310	None	0	Human	Functional	pIC50	=	7.4	7.4	-933	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2134	33	32	28	-5.0	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(nn3)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168277258	190708	None	0	Human	Functional	pIC50	=	5.4	5.4	-870	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1243	15	14	15	-0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5182345	190708	None	0	Human	Functional	pIC50	=	5.4	5.4	-870	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1243	15	14	15	-0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	168281389	190920	None	0	Human	Functional	pIC50	=	7.2	7.2	-218	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2149	33	33	26	-5.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC3=C(SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2)C(=O)NC3=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5185405	190920	None	0	Human	Functional	pIC50	=	7.2	7.2	-218	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2149	33	33	26	-5.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC3=C(SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2)C(=O)NC3=O	10.1021/acs.jmedchem.2c00793
	168277761	190298	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2342	37	34	29	-3.4	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5175981	190298	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2342	37	34	29	-3.4	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168295726	192403	None	0	Human	Functional	pIC50	=	6.1	6.1	-9120	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2547	50	34	33	-2.8	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCOCCC(=O)O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5207936	192403	None	0	Human	Functional	pIC50	=	6.1	6.1	-9120	4	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2547	50	34	33	-2.8	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCOCCC(=O)O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168281421	190955	None	0	Human	Functional	pIC50	=	7.1	7.1	-794	3	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2430	43	34	31	-3.4	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5185945	190955	None	0	Human	Functional	pIC50	=	7.1	7.1	-794	3	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2430	43	34	31	-3.4	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL413573	213073	None	0	Human	Functional	pKd	=	8.7	8.7	-1	4	Activity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC5R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](C(C)C)NC1=O	10.1021/jm0510326
	44445085	97072	None	0	Human	Functional	pKd	=	8.7	8.7	-1	4	Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulationAntagonist activity at human MC5 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation	ChEMBL	879	9	11	9	1.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL267265	97072	None	0	Human	Functional	pKd	=	8.7	8.7	-1	4	Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulationAntagonist activity at human MC5 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation	ChEMBL	879	9	11	9	1.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	132938008	159511	None	0	Mouse	Functional	pKd	=	7.5	7.5	-891	5	Antagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4102048	159511	None	0	Mouse	Functional	pKd	=	7.5	7.5	-891	5	Antagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	155561116	174971	None	0	Mouse	Functional	pKd	=	6.5	6.5	-269	5	Antagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	964	11	11	11	-1.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4566163	174971	None	0	Mouse	Functional	pKd	=	6.5	6.5	-269	5	Antagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	964	11	11	11	-1.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	122184635	122432	None	0	Human	Functional	pKd	=	7.4	7.4	2	4	Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAntagonist activity at human MC5 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600916	122432	None	0	Human	Functional	pKd	=	7.4	7.4	2	4	Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAntagonist activity at human MC5 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	162650385	180069	None	0	Mouse	Functional	pKd	=	7.4	7.4	-	1	Antagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-0.8	C[C@@H]1NC(=O)[C@H](CN)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4747952	180069	None	0	Mouse	Functional	pKd	=	7.4	7.4	-	1	Antagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-0.8	C[C@@H]1NC(=O)[C@H](CN)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL3577981	211747	None	1	Mouse	Functional	pKd	=	6.4	6.4	-177	5	Antagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL3577981	211747	None	1	Mouse	Functional	pKd	=	6.4	6.4	-177	5	Antagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	44577515	189005	None	0	Human	Functional	pKd	=	8.3	8.3	-2	2	Antagonist activity at human melanocortin 5 receptor expressed in HEK293 cellsAntagonist activity at human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	943	12	11	11	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL508816	189005	None	0	Human	Functional	pKd	=	8.3	8.3	-2	2	Antagonist activity at human melanocortin 5 receptor expressed in HEK293 cellsAntagonist activity at human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	943	12	11	11	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	132938008	159511	None	0	Mouse	Functional	pKd	=	7.3	7.3	-891	5	Antagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4102048	159511	None	0	Mouse	Functional	pKd	=	7.3	7.3	-891	5	Antagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	155544852	174937	None	0	Mouse	Functional	pKd	=	6.3	6.3	-331	5	Antagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	977	12	10	10	-0.5	CC(C)[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4565367	174937	None	0	Mouse	Functional	pKd	=	6.3	6.3	-331	5	Antagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	977	12	10	10	-0.5	CC(C)[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	162645080	179448	None	0	Mouse	Functional	pKd	=	6.1	6.1	-	1	Antagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	976	12	9	10	-0.9	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4740561	179448	None	0	Mouse	Functional	pKd	=	6.1	6.1	-	1	Antagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	976	12	9	10	-0.9	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	155548853	173807	None	0	Mouse	Functional	pKd	=	6.1	6.1	-758	5	Antagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	1005	13	10	10	-0.6	CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4538274	173807	None	0	Mouse	Functional	pKd	=	6.1	6.1	-758	5	Antagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	1005	13	10	10	-0.6	CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	131839615	212634	None	26	Mouse	Functional	pEC50	=	8.0	8.0	-1	7	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	16133835	212634	None	26	Mouse	Functional	pEC50	=	8.0	8.0	-1	7	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	CHEMBL407070	212634	None	26	Mouse	Functional	pEC50	=	8.0	8.0	-1	7	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	131839615	212634	None	26	Human	Functional	pIC50	=	8.1	8.1	1	7	NoneNone	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	16133835	212634	None	26	Human	Functional	pIC50	=	8.1	8.1	1	7	NoneNone	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	CHEMBL407070	212634	None	26	Human	Functional	pIC50	=	8.1	8.1	1	7	NoneNone	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	1341	3074	None	0	Human	Functional	pIC50	None	10.5	10.5	6	3	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12431055
	1335	315	None	0	Human	Functional	pIC50	None	6.5	6.5	-630	3	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9892020
	1342	247	None	0	Human	Functional	pIC50	None	8	8.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12904077
	1324	302	None	25	Human	Functional	pIC50	None	9	9.0	-13	9	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	16154396	302	None	25	Human	Functional	pIC50	None	9	9.0	-13	9	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	16197727	302	None	25	Human	Functional	pIC50	None	9	9.0	-13	9	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	44285019	302	None	25	Human	Functional	pIC50	None	9	9.0	-13	9	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	57514683	302	None	25	Human	Functional	pIC50	None	9	9.0	-13	9	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	91898441	302	None	25	Human	Functional	pIC50	None	9	9.0	-13	9	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	CHEMBL441738	302	None	25	Human	Functional	pIC50	None	9	9.0	-13	9	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	DB04931	302	None	25	Human	Functional	pIC50	None	9	9.0	-13	9	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	1323	2686	None	55	Human	Functional	pIC50	None	9	9.0	-181	8	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	92432	2686	None	55	Human	Functional	pIC50	None	9	9.0	-181	8	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	CHEMBL430239	2686	None	55	Human	Functional	pIC50	None	9	9.0	-181	8	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	44366081	10260	None	0	Human	Binding	pEC50	=	10.5	10.5	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	1036	15	13	11	0.4	CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	CHEMBL1161313	10260	None	0	Human	Binding	pEC50	=	10.5	10.5	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	1036	15	13	11	0.4	CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	1323	2686	None	55	Mouse	Binding	pEC50	=	10.2	10.2	-	3	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	92432	2686	None	55	Mouse	Binding	pEC50	=	10.2	10.2	-	3	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	CHEMBL430239	2686	None	55	Mouse	Binding	pEC50	=	10.2	10.2	-	3	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	1324	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	16154396	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	16197727	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	44285019	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	57514683	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	91898441	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	CHEMBL441738	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	DB04931	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	1324	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	16154396	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	16197727	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	44285019	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	57514683	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	91898441	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	CHEMBL441738	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	DB04931	302	None	25	Mouse	Binding	pEC50	=	10.2	10.2	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	101176453	182960	None	0	Human	Binding	pEC50	=	10.1	10.1	-	0	Agonist activity at human melanocortin receptor 5Agonist activity at human melanocortin receptor 5	ChEMBL	1034	15	12	10	0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01029
	CHEMBL4792986	182960	None	0	Human	Binding	pEC50	=	10.1	10.1	-	0	Agonist activity at human melanocortin receptor 5Agonist activity at human melanocortin receptor 5	ChEMBL	1034	15	12	10	0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01029
	CHEMBL1161322	208506	None	0	Human	Binding	pEC50	=	10.1	10.1	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	1324	302	None	25	Mouse	Binding	pEC50	=	10.0	10.0	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	16154396	302	None	25	Mouse	Binding	pEC50	=	10.0	10.0	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	16197727	302	None	25	Mouse	Binding	pEC50	=	10.0	10.0	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	44285019	302	None	25	Mouse	Binding	pEC50	=	10.0	10.0	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	57514683	302	None	25	Mouse	Binding	pEC50	=	10.0	10.0	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	91898441	302	None	25	Mouse	Binding	pEC50	=	10.0	10.0	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	CHEMBL441738	302	None	25	Mouse	Binding	pEC50	=	10.0	10.0	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	DB04931	302	None	25	Mouse	Binding	pEC50	=	10.0	10.0	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	CHEMBL2096742	209204	None	0	Human	Binding	pEC50	=	9.9	9.9	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0202526
	CHEMBL442504	213914	None	0	Human	Binding	pEC50	=	9.9	9.9	-1	3	Signal transduction efficacy in cAMP assay in CHO cells expressing human melanocortin receptor 5Signal transduction efficacy in cAMP assay in CHO cells expressing human melanocortin receptor 5	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm010165y
	1323	2686	None	55	Mouse	Binding	pEC50	=	9.8	9.8	-	3	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	92432	2686	None	55	Mouse	Binding	pEC50	=	9.8	9.8	-	3	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	CHEMBL430239	2686	None	55	Mouse	Binding	pEC50	=	9.8	9.8	-	3	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	44327392	141861	None	0	Mouse	Binding	pEC50	=	9.8	9.8	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL	1025	21	12	12	-0.6	CCCC[C@H](NC(C)=O)C(=O)N1C(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]1CC(=O)O	10.1021/jm0104872
	CHEMBL386583	141861	None	0	Mouse	Binding	pEC50	=	9.8	9.8	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL	1025	21	12	12	-0.6	CCCC[C@H](NC(C)=O)C(=O)N1C(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]1CC(=O)O	10.1021/jm0104872
	CHEMBL1161323	208507	None	0	Human	Binding	pEC50	=	9.7	9.7	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2C[C@@]3(C)CCCC[C@@]3(C)N2C1=O	10.1021/jm0202526
	16132144	209277	None	36	Mouse	Binding	pEC50	=	9.5	9.5	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049010r
	16133793	209277	None	36	Mouse	Binding	pEC50	=	9.5	9.5	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049010r
	44273719	209277	None	36	Mouse	Binding	pEC50	=	9.5	9.5	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049010r
	CHEMBL214332	209277	None	36	Mouse	Binding	pEC50	=	9.5	9.5	-	4	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049010r
	CHEMBL2369959	209738	None	0	Mouse	Binding	pEC50	=	9.4	9.4	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	16132144	209277	None	36	Mouse	Binding	pEC50	=	9.4	9.4	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm020296e
	16133793	209277	None	36	Mouse	Binding	pEC50	=	9.4	9.4	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm020296e
	44273719	209277	None	36	Mouse	Binding	pEC50	=	9.4	9.4	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm020296e
	CHEMBL214332	209277	None	36	Mouse	Binding	pEC50	=	9.4	9.4	-	4	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm020296e
	16132144	209277	None	36	Mouse	Binding	pEC50	=	9.4	9.4	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0104872
	16133793	209277	None	36	Mouse	Binding	pEC50	=	9.4	9.4	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0104872
	44273719	209277	None	36	Mouse	Binding	pEC50	=	9.4	9.4	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0104872
	CHEMBL214332	209277	None	36	Mouse	Binding	pEC50	=	9.4	9.4	-	4	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0104872
	CHEMBL2369967	209746	None	0	Mouse	Binding	pEC50	=	9.3	9.3	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	1323	2686	None	55	Mouse	Binding	pEC50	=	9.2	9.2	-	3	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	92432	2686	None	55	Mouse	Binding	pEC50	=	9.2	9.2	-	3	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	CHEMBL430239	2686	None	55	Mouse	Binding	pEC50	=	9.2	9.2	-	3	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	CHEMBL2369964	209743	None	0	Mouse	Binding	pEC50	=	9.0	9.0	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	44322868	106006	None	0	Human	Binding	pEC50	=	9	9.0	-4	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	917	11	12	9	0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL313279	106006	None	0	Human	Binding	pEC50	=	9	9.0	-4	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	917	11	12	9	0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL2369963	209742	None	0	Mouse	Binding	pEC50	=	8.7	8.7	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL1161318	208503	None	0	Human	Binding	pEC50	=	8	8.0	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCCC2)NC1=O	10.1021/jm0202526
	CHEMBL347364	211711	None	0	Mouse	Binding	pEC50	=	7	7.0	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/jm020296e
	CHEMBL191063	209077	None	0	Mouse	Binding	pEC50	=	7	7.0	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL365794	212039	None	0	Mouse	Binding	pEC50	=	6	6.0	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	11038873	171878	None	0	Human	Binding	pEC50	=	5	5.0	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	545	12	3	6	2.9	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](N)Cc2c[nH]cn2)CC1	10.1021/jm025600i
	CHEMBL446941	171878	None	0	Human	Binding	pEC50	=	5	5.0	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	545	12	3	6	2.9	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](N)Cc2c[nH]cn2)CC1	10.1021/jm025600i
	10260053	168201	None	0	Human	Binding	pEC50	=	6.0	6.0	-6	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	871	27	12	10	-1.1	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm020021z
	CHEMBL433413	168201	None	0	Human	Binding	pEC50	=	6.0	6.0	-6	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	871	27	12	10	-1.1	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm020021z
	CHEMBL347216	211710	None	0	Mouse	Binding	pEC50	=	7.9	7.9	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/jm020296e
	CHEMBL190080	209060	None	0	Mouse	Binding	pEC50	=	7.9	7.9	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL275303	210819	None	0	Mouse	Binding	pEC50	=	4.9	4.9	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N1Cc2ccccc2C[C@@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL432027	213629	None	0	Mouse	Binding	pEC50	=	5.9	5.9	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	46877881	201816	None	0	Human	Binding	pEC50	=	5.9	5.9	-5	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	813	9	10	8	-0.3	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL606990	201816	None	0	Human	Binding	pEC50	=	5.9	5.9	-5	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	813	9	10	8	-0.3	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL94391	215907	None	0	Mouse	Binding	pEC50	=	6.9	6.9	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL327479	211292	None	0	Mouse	Binding	pEC50	=	6.8	6.8	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL433522	213639	None	0	Mouse	Binding	pEC50	=	4.8	4.8	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccncc1)C(N)=O	10.1021/jm020296e
	CHEMBL190551	209064	None	0	Mouse	Binding	pEC50	=	7.8	7.8	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL348901	211714	None	0	Mouse	Binding	pEC50	=	6.8	6.8	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/jm020296e
	44323234	168054	None	0	Human	Binding	pEC50	=	6.8	6.8	-11	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL432377	168054	None	0	Human	Binding	pEC50	=	6.8	6.8	-11	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL1161321	208505	None	0	Human	Binding	pEC50	=	7.8	7.8	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(Cc3ccccc3C2)NC1=O	10.1021/jm0202526
	CHEMBL2371147	210015	None	0	Mouse	Binding	pEC50	=	6.8	6.8	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@]1(C(N)=O)CCc2ccccc2C1	10.1021/jm020296e
	CHEMBL3422431	211668	None	0	Mouse	Binding	pEC50	=	5.8	5.8	-	1	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/ml500340z
	118735610	118879	None	0	Mouse	Binding	pEC50	=	4.7	4.7	-	2	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/ml500340z
	CHEMBL3422433	118879	None	0	Mouse	Binding	pEC50	=	4.7	4.7	-	2	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/ml500340z
	CHEMBL190953	209075	None	0	Mouse	Binding	pEC50	=	5.7	5.7	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL372237	212170	None	0	Mouse	Binding	pEC50	=	5.7	5.7	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL2372589	210271	None	0	Human	Binding	pEC50	=	8.7	8.7	-	2	Activity of cyclic alpha MSH analogues at human melanocortin receptor Melanocortin 5 receptorActivity of cyclic alpha MSH analogues at human melanocortin receptor Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2Cc3ccccc3CN2C1=O	10.1021/jm0202526
	CHEMBL5282523	194156	None	0	Human	Binding	pEC50	=	8.7	8.7	-	0	Agonist activity at human melanocortin receptor 5Agonist activity at human melanocortin receptor 5	ChEMBL	1096	15	12	10	1.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2Cc3ccccc3CN2C1=O	10.1021/acs.jmedchem.6b01029
	CHEMBL2369969	209748	None	0	Mouse	Binding	pEC50	=	8.7	8.7	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL2096742	209204	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	2	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm049010r
	CHEMBL2369973	209752	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	1325	3598	None	14	Mouse	Binding	pEC50	=	8.6	8.6	-	7	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	6440621	3598	None	14	Mouse	Binding	pEC50	=	8.6	8.6	-	7	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	9898183	3598	None	14	Mouse	Binding	pEC50	=	8.6	8.6	-	7	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	CHEMBL3422426	3598	None	14	Mouse	Binding	pEC50	=	8.6	8.6	-	7	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	118735609	118878	None	0	Mouse	Binding	pEC50	=	4.7	4.7	-	2	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/ml500340z
	CHEMBL3422432	118878	None	0	Mouse	Binding	pEC50	=	4.7	4.7	-	2	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/ml500340z
	44269217	30258	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	649	14	3	6	4.4	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)c2ccccc2)CC1	10.1021/jm025600i
	CHEMBL13910	30258	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	649	14	3	6	4.4	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)c2ccccc2)CC1	10.1021/jm025600i
	CHEMBL2369974	209753	None	0	Mouse	Binding	pEC50	=	7.7	7.7	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL329490	211315	None	0	Mouse	Binding	pEC50	=	5.7	5.7	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	118735606	118877	None	0	Mouse	Binding	pEC50	=	4.6	4.6	-	1	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL	877	18	9	7	2.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/ml500340z
	CHEMBL3422429	118877	None	0	Mouse	Binding	pEC50	=	4.6	4.6	-	1	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL	877	18	9	7	2.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/ml500340z
	11828678	207871	None	0	Mouse	Binding	pEC50	=	5.6	5.6	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL	721	16	8	6	1.0	CC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1	10.1021/jm0104872
	CHEMBL96531	207871	None	0	Mouse	Binding	pEC50	=	5.6	5.6	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL	721	16	8	6	1.0	CC(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1	10.1021/jm0104872
	CHEMBL2096745	209205	None	0	Mouse	Binding	pEC50	=	4.6	4.6	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/jm020296e
	CHEMBL191120	209078	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL370321	212165	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	44269214	98492	None	0	Human	Binding	pEC50	=	5.6	5.6	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	546	12	3	6	3.0	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](O)Cc2c[nH]cn2)CC1	10.1021/jm025600i
	CHEMBL276012	98492	None	0	Human	Binding	pEC50	=	5.6	5.6	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	546	12	3	6	3.0	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](O)Cc2c[nH]cn2)CC1	10.1021/jm025600i
	118735604	118875	None	0	Mouse	Binding	pEC50	=	5.6	5.6	-	2	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL	860	18	10	6	2.0	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/ml500340z
	CHEMBL3422427	118875	None	0	Mouse	Binding	pEC50	=	5.6	5.6	-	2	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL	860	18	10	6	2.0	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/ml500340z
	CHEMBL329847	211319	None	0	Mouse	Binding	pEC50	=	5.5	5.5	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL2369982	209761	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL2369960	209739	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL2370154	209799	None	0	Human	Binding	pEC50	=	8.5	8.5	-6	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm020021z
	CHEMBL2369965	209744	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	44369234	45244	None	0	Mouse	Binding	pEC50	=	8.4	8.4	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL	685	18	9	7	-0.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm020296e
	CHEMBL152612	45244	None	0	Mouse	Binding	pEC50	=	8.4	8.4	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL	685	18	9	7	-0.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm020296e
	CHEMBL264190	210606	None	1	Mouse	Binding	pEC50	=	8.4	8.4	-	2	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL330233	211329	None	0	Mouse	Binding	pEC50	=	6.5	6.5	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL365913	212041	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL188738	209057	None	0	Mouse	Binding	pEC50	=	6.5	6.5	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL189991	209059	None	0	Mouse	Binding	pEC50	=	5.5	5.5	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL2369976	209755	None	0	Mouse	Binding	pEC50	=	5.5	5.5	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL154153	208798	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1cccc2ccccc12)C(N)=O	10.1021/jm020296e
	CHEMBL264190	210606	None	1	Mouse	Binding	pEC50	=	7.5	7.5	-	2	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm020296e
	CHEMBL350012	211720	None	0	Mouse	Binding	pEC50	=	4.4	4.4	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]cn1)C(N)=O	10.1021/jm020296e
	CHEMBL96871	215919	None	0	Mouse	Binding	pEC50	=	6.4	6.4	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL431092	213620	None	0	Mouse	Binding	pEC50	=	6.4	6.4	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL2371150	210016	None	0	Mouse	Binding	pEC50	=	4.4	4.4	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(N)=O	10.1021/jm020296e
	CHEMBL1161320	208504	None	0	Human	Binding	pEC50	=	6.4	6.4	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CC2)NC1=O	10.1021/jm0202526
	44269189	98336	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	587	13	3	6	3.1	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(C)=O)CC1	10.1021/jm025600i
	CHEMBL275067	98336	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	587	13	3	6	3.1	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(C)=O)CC1	10.1021/jm025600i
	CHEMBL190203	209062	None	0	Mouse	Binding	pEC50	=	5.4	5.4	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12)C(C)=O	10.1021/jm0490033
	CHEMBL264190	210606	None	1	Mouse	Binding	pEC50	=	8.3	8.3	-	2	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/ml500340z
	CHEMBL357558	211741	None	0	Mouse	Binding	pEC50	=	8.3	8.3	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/jm020296e
	CHEMBL2369983	209762	None	0	Mouse	Binding	pEC50	=	8.3	8.3	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL330561	211331	None	0	Mouse	Binding	pEC50	=	7.4	7.4	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL317969	211206	None	0	Mouse	Binding	pEC50	=	6.4	6.4	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	44347840	161922	None	0	Human	Binding	pEC50	=	7.4	7.4	-208	3	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0202526
	91932630	161922	None	0	Human	Binding	pEC50	=	7.4	7.4	-208	3	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0202526
	CHEMBL415333	161922	None	0	Human	Binding	pEC50	=	7.4	7.4	-208	3	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0202526
	CHEMBL2369966	209745	None	0	Mouse	Binding	pEC50	=	7.4	7.4	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL2369961	209740	None	0	Mouse	Binding	pEC50	=	6.4	6.4	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCc3ccccc3C2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	9915813	38487	None	15	Human	Binding	pEC50	=	5.4	5.4	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	559	12	2	7	3.0	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](N)Cc2cncn2C)CC1	10.1021/jm025600i
	CHEMBL14642	38487	None	15	Human	Binding	pEC50	=	5.4	5.4	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	559	12	2	7	3.0	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](N)Cc2cncn2C)CC1	10.1021/jm025600i
	CHEMBL1161316	208502	None	0	Human	Binding	pEC50	=	7.4	7.4	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	10.1021/jm0202526
	10101361	155701	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	1	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL	717	16	8	6	2.4	CC(=O)Nc1cc2ccccc2cc1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL405174	155701	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	1	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL	717	16	8	6	2.4	CC(=O)Nc1cc2ccccc2cc1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL151906	208792	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1csc2ccccc12)C(N)=O	10.1021/jm020296e
	CHEMBL154251	208799	None	0	Mouse	Binding	pEC50	=	6.3	6.3	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/jm020296e
	CHEMBL2369975	209754	None	0	Mouse	Binding	pEC50	=	8.3	8.3	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL2369970	209749	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL2371832	210133	None	0	Mouse	Binding	pEC50	=	6.3	6.3	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL432201	213631	None	0	Mouse	Binding	pEC50	=	6.3	6.3	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	44366171	121292	None	0	Human	Binding	pEC50	=	6.3	6.3	-	0	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm0202526
	CHEMBL358015	121292	None	0	Human	Binding	pEC50	=	6.3	6.3	-	0	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm0202526
	CHEMBL3422430	211667	None	0	Mouse	Binding	pEC50	=	5.3	5.3	-	1	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/ml500340z
	44322795	206924	None	0	Human	Binding	pEC50	=	6.3	6.3	-114	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	853	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL91041	206924	None	0	Human	Binding	pEC50	=	6.3	6.3	-114	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	853	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL94369	215906	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL2371835	210135	None	0	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL186970	209052	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL2371829	210132	None	0	Mouse	Binding	pEC50	=	5.2	5.2	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL2371833	210134	None	0	Mouse	Binding	pEC50	=	5.2	5.2	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	44323020	168994	None	0	Human	Binding	pEC50	=	6.2	6.2	-741	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	951	11	12	9	1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL439188	168994	None	0	Human	Binding	pEC50	=	6.2	6.2	-741	3	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cellsEffective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL	951	11	12	9	1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL320157	211224	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL2369968	209747	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC1=O	10.1021/jm049010r
	CHEMBL2369971	209750	None	0	Mouse	Binding	pEC50	=	8.1	8.1	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL2096693	209202	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/jm020296e
	CHEMBL2369962	209741	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL152555	208793	None	0	Mouse	Binding	pEC50	=	5.2	5.2	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(N)=O)C(c1ccccc1)c1ccccc1	10.1021/jm020296e
	CHEMBL358833	211801	None	0	Mouse	Binding	pEC50	=	5.1	5.1	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(N)=O)C(c1ccccc1)c1ccccc1	10.1021/jm020296e
	CHEMBL346925	211709	None	0	Mouse	Binding	pEC50	=	6.1	6.1	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O	10.1021/jm020296e
	118735605	118876	None	0	Mouse	Binding	pEC50	=	5.1	5.1	-	1	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL	897	19	9	6	3.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/ml500340z
	CHEMBL3422428	118876	None	0	Mouse	Binding	pEC50	=	5.1	5.1	-	1	Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL	897	19	9	6	3.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/ml500340z
	CHEMBL2369972	209751	None	0	Mouse	Binding	pEC50	=	5.1	5.1	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL373344	212173	None	0	Mouse	Binding	pEC50	=	6.1	6.1	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL188459	209055	None	0	Mouse	Binding	pEC50	=	5.1	5.1	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL190102	209061	None	0	Mouse	Binding	pEC50	=	5.1	5.1	-	0	Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cellsEffective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N(CC(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O)Cc1ccccc1	10.1021/jm0490033
	CHEMBL2369977	209756	None	0	Mouse	Binding	pEC50	=	6.1	6.1	-	0	Effective concentration for mouse Melanocortin-5 receptorEffective concentration for mouse Melanocortin-5 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL349795	211718	None	0	Mouse	Binding	pEC50	=	6.1	6.1	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1cccs1)C(N)=O	10.1021/jm020296e
	CHEMBL152986	208795	None	0	Mouse	Binding	pEC50	=	6.1	6.1	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm020296e
	CHEMBL317968	211205	None	0	Mouse	Binding	pEC50	=	7.0	7.0	-	0	In vitro activation of mouse recombinant Melanocortin-5 receptor.In vitro activation of mouse recombinant Melanocortin-5 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	11813437	98527	None	0	Human	Binding	pEC50	=	5.0	5.0	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	530	12	2	5	4.0	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)CCc2c[nH]cn2)CC1	10.1021/jm025600i
	CHEMBL276301	98527	None	0	Human	Binding	pEC50	=	5.0	5.0	-	0	In vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 5 receptor (MC5R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	530	12	2	5	4.0	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)CCc2c[nH]cn2)CC1	10.1021/jm025600i
	CHEMBL2371147	210015	None	0	Mouse	Binding	pEC50	=	6.0	6.0	-	0	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsActivity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@]1(C(N)=O)CCc2ccccc2C1	10.1021/jm020296e
	44366081	10260	None	0	Human	Binding	pIC50	=	10.6	10.6	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	1036	15	13	11	0.4	CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	CHEMBL1161313	10260	None	0	Human	Binding	pIC50	=	10.6	10.6	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	1036	15	13	11	0.4	CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	CHEMBL1161322	208506	None	0	Human	Binding	pIC50	=	10.5	10.5	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	CHEMBL2096742	209204	None	0	Human	Binding	pIC50	=	10.1	10.1	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0202526
	16049796	83464	None	0	Human	Binding	pIC50	=	10	10.0	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL	543	11	5	4	2.8	N=C(N)NCCC[C@H](NC(=O)CCc1c[nH]c2ccccc12)C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	CHEMBL220018	83464	None	0	Human	Binding	pIC50	=	10	10.0	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL	543	11	5	4	2.8	N=C(N)NCCC[C@H](NC(=O)CCc1c[nH]c2ccccc12)C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	44418438	166008	None	0	Human	Binding	pIC50	=	10	10.0	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL	458	8	2	3	3.5	O=C(CCC(=O)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1)NCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2006.07.015
	CHEMBL425442	166008	None	0	Human	Binding	pIC50	=	10	10.0	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL	458	8	2	3	3.5	O=C(CCC(=O)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1)NCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2006.07.015
	CHEMBL1161323	208507	None	0	Human	Binding	pIC50	=	10.0	10.0	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2C[C@@]3(C)CCCC[C@@]3(C)N2C1=O	10.1021/jm0202526
	CHEMBL2371966	210161	None	0	Human	Binding	pIC50	=	9.8	9.8	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm0614275
	44418413	83211	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL	500	11	2	3	4.7	O=C(CCc1c[nH]c2ccccc12)NCCCCCC(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	CHEMBL218558	83211	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL	500	11	2	3	4.7	O=C(CCc1c[nH]c2ccccc12)NCCCCCC(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	44418437	83173	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL	458	8	2	3	3.5	O=C(CCC(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1)NCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2006.07.015
	CHEMBL218361	83173	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL	458	8	2	3	3.5	O=C(CCC(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1)NCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2006.07.015
	CHEMBL501592	214139	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	CHEMBL2371962	210157	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0614275
	44418420	141945	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL	387	5	1	2	4.0	O=C(CCc1c[nH]c2ccccc12)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	CHEMBL387169	141945	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL	387	5	1	2	4.0	O=C(CCc1c[nH]c2ccccc12)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	1324	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Displacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	16154396	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Displacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	16197727	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Displacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	44285019	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Displacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	57514683	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Displacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	91898441	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Displacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	CHEMBL441738	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Displacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	DB04931	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Displacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	1324	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	16154396	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	16197727	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	44285019	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	57514683	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	91898441	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	CHEMBL441738	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	DB04931	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	1324	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	16154396	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	16197727	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	44285019	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	57514683	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	91898441	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	CHEMBL441738	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	DB04931	302	None	25	Human	Binding	pIC50	=	9.1	9.1	-6	4	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	CHEMBL2096742	209204	None	0	Human	Binding	pIC50	=	9.1	9.1	-	2	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm801300c
	CHEMBL2371968	210163	None	0	Human	Binding	pIC50	=	9.0	9.0	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2CC3CCCCC3N2C1=O	10.1021/jm0614275
	CHEMBL524861	215621	None	0	Human	Binding	pIC50	=	9.0	9.0	-	0	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	CHEMBL2372589	210271	None	0	Human	Binding	pIC50	=	8.9	8.9	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2Cc3ccccc3CN2C1=O	10.1021/jm0202526
	CHEMBL204310	209162	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/jm0510326
	1323	2686	None	55	Human	Binding	pIC50	=	8.8	8.8	-	3	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	92432	2686	None	55	Human	Binding	pIC50	=	8.8	8.8	-	3	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	8.8	8.8	-	3	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	CHEMBL2371965	210160	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2CC3CCCCC3N2C1=O	10.1021/jm0614275
	71449048	78479	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1483	33	16	22	-2.5	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL2111808	78479	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1483	33	16	22	-2.5	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL203760	209159	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm0510326
	CHEMBL446185	213942	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0510326
	CHEMBL1775062	208878	None	0	Human	Binding	pIC50	=	6	6.0	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma counting	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1016/j.bmcl.2011.03.019
	137659790	159320	None	0	Human	Binding	pIC50	=	6	6.0	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL4099889	159320	None	0	Human	Binding	pIC50	=	6	6.0	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL190551	209064	None	0	Mouse	Binding	pIC50	=	6	6.0	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL408509	212718	None	0	Human	Binding	pIC50	=	6	6.0	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL5077811	214514	None	0	Human	Binding	pIC50	=	5	5.0	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c00095
	CHEMBL372237	212170	None	0	Mouse	Binding	pIC50	=	5	5.0	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	44396987	67191	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	CHEMBL187774	67191	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	122184912	122556	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601430	122556	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	44397220	167302	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	CN1C[C@@H]2CC[C@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2	10.1016/j.bmcl.2005.05.109
	CHEMBL429387	167302	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	CN1C[C@@H]2CC[C@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2	10.1016/j.bmcl.2005.05.109
	CHEMBL264190	210606	None	1	Human	Binding	pIC50	=	7.0	7.0	-	2	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL2096759	209206	None	0	Human	Binding	pIC50	=	8.0	8.0	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	44408287	75384	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	620	8	2	5	5.1	C[C@@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL203911	75384	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	620	8	2	5	5.1	C[C@@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL427205	213350	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC1=O	10.1021/jm0510326
	49862378	15040	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	534	8	0	4	4.6	CC(=O)N(CC(CC(C)C)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	CHEMBL1209321	15040	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	534	8	0	4	4.6	CC(=O)N(CC(CC(C)C)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	15953833	78972	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL2113037	78972	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	137647538	157960	None	0	Human	Binding	pIC50	=	6.0	6.0	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4084765	157960	None	0	Human	Binding	pIC50	=	6.0	6.0	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	137646617	157542	None	0	Human	Binding	pIC50	=	5.0	5.0	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4080223	157542	None	0	Human	Binding	pIC50	=	5.0	5.0	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL5085972	215001	None	0	Human	Binding	pIC50	=	5.0	5.0	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.1c00095
	CHEMBL3601426	211824	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	16132144	209277	None	36	Human	Binding	pIC50	=	6.9	6.9	-100	4	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	16133793	209277	None	36	Human	Binding	pIC50	=	6.9	6.9	-100	4	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	44273719	209277	None	36	Human	Binding	pIC50	=	6.9	6.9	-100	4	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	CHEMBL214332	209277	None	36	Human	Binding	pIC50	=	6.9	6.9	-100	4	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	CHEMBL1161321	208505	None	0	Human	Binding	pIC50	=	7.9	7.9	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(Cc3ccccc3C2)NC1=O	10.1021/jm0202526
	145976444	163961	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	889	11	12	9	-0.1	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4207858	163961	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	889	11	12	9	-0.1	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	24774521	154256	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	861	9	10	8	0.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)/C=C\C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL398635	154256	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	861	9	10	8	0.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)/C=C\C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	44397652	123632	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cellsInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cells	ChEMBL	620	10	2	7	6.0	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)c2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL361883	123632	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cellsInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cells	ChEMBL	620	10	2	7	6.0	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)c2=O)cc1	10.1016/j.bmcl.2005.06.033
	155546131	173528	None	0	Mouse	Binding	pIC50	=	4.9	4.9	-	3	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	929	9	8	10	-0.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4531291	173528	None	0	Mouse	Binding	pIC50	=	4.9	4.9	-	3	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	929	9	8	10	-0.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	6918276	15609	None	7	Human	Binding	pIC50	=	6.9	6.9	-12	8	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	CHEMBL1221512	15609	None	7	Human	Binding	pIC50	=	6.9	6.9	-12	8	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	46919520	15136	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	597	4	0	5	6.3	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	CHEMBL1209788	15136	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	597	4	0	5	6.3	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	44431512	145922	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cells	ChEMBL	1038	14	12	10	0.9	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	CHEMBL391796	145922	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cells	ChEMBL	1038	14	12	10	0.9	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	CHEMBL5092761	215386	None	0	Human	Binding	pIC50	=	5.9	5.9	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL3577981	211747	None	1	Mouse	Binding	pIC50	=	4.9	4.9	-29	3	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL188738	209057	None	0	Mouse	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL5087814	215117	None	0	Human	Binding	pIC50	=	6.9	6.9	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44448660	94971	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	575	6	1	3	6.9	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL254589	94971	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	575	6	1	3	6.9	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	122184578	122428	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600839	122428	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	44577515	189005	None	0	Human	Binding	pIC50	=	6.9	6.9	-	1	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	943	12	11	11	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL508816	189005	None	0	Human	Binding	pIC50	=	6.9	6.9	-	1	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	943	12	11	11	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	49862375	15037	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	624	8	0	6	5.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cccnn1	10.1016/j.bmcl.2010.06.038
	CHEMBL1209318	15037	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	624	8	0	6	5.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cccnn1	10.1016/j.bmcl.2010.06.038
	54586246	60815	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	599	8	3	4	5.0	CC[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](CC)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1762008	60815	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	599	8	3	4	5.0	CC[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](CC)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL376339	212242	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	44277696	101203	None	0	Human	Binding	pIC50	=	4.9	4.9	-	0	Binding affinity towards human Melanocortin 5 receptor using radiolabeled NDP-MSH displacementBinding affinity towards human Melanocortin 5 receptor using radiolabeled NDP-MSH displacement	ChEMBL	770	22	10	8	-0.7	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1016/j.bmcl.2005.08.012
	CHEMBL29582	101203	None	0	Human	Binding	pIC50	=	4.9	4.9	-	0	Binding affinity towards human Melanocortin 5 receptor using radiolabeled NDP-MSH displacementBinding affinity towards human Melanocortin 5 receptor using radiolabeled NDP-MSH displacement	ChEMBL	770	22	10	8	-0.7	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1016/j.bmcl.2005.08.012
	6918813	131369	None	3	Human	Binding	pIC50	=	4.9	4.9	-	0	Concentration for 50% inhibition of human melanocortin-5 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandConcentration for 50% inhibition of human melanocortin-5 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL368876	131369	None	3	Human	Binding	pIC50	=	4.9	4.9	-	0	Concentration for 50% inhibition of human melanocortin-5 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandConcentration for 50% inhibition of human melanocortin-5 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	44277696	101203	None	0	Human	Binding	pIC50	=	4.9	4.9	-	0	Binding affinity towards human melanocortin receptor hMC5R by using radioligand NDP-MSHBinding affinity towards human melanocortin receptor hMC5R by using radioligand NDP-MSH	ChEMBL	770	22	10	8	-0.7	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1016/s0960-894x(02)00830-2
	CHEMBL29582	101203	None	0	Human	Binding	pIC50	=	4.9	4.9	-	0	Binding affinity towards human melanocortin receptor hMC5R by using radioligand NDP-MSHBinding affinity towards human melanocortin receptor hMC5R by using radioligand NDP-MSH	ChEMBL	770	22	10	8	-0.7	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1016/s0960-894x(02)00830-2
	118735103	118801	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	698	15	8	9	-0.8	CC(=O)N[C@H]1Cn2nncc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421680	118801	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	698	15	8	9	-0.8	CC(=O)N[C@H]1Cn2nncc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	1324	302	None	25	Mouse	Binding	pIC50	=	6.9	6.9	-	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	16154396	302	None	25	Mouse	Binding	pIC50	=	6.9	6.9	-	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	16197727	302	None	25	Mouse	Binding	pIC50	=	6.9	6.9	-	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	44285019	302	None	25	Mouse	Binding	pIC50	=	6.9	6.9	-	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	57514683	302	None	25	Mouse	Binding	pIC50	=	6.9	6.9	-	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	91898441	302	None	25	Mouse	Binding	pIC50	=	6.9	6.9	-	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	CHEMBL441738	302	None	25	Mouse	Binding	pIC50	=	6.9	6.9	-	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	DB04931	302	None	25	Mouse	Binding	pIC50	=	6.9	6.9	-	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	54584301	60808	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	585	6	2	4	4.6	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1C	10.1016/j.bmcl.2011.02.090
	CHEMBL1761872	60808	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	585	6	2	4	4.6	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1C	10.1016/j.bmcl.2011.02.090
	10483153	60809	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1761873	60809	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	54584302	60810	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1761874	60810	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@H](C)N1	10.1016/j.bmcl.2011.02.090
	44397461	126225	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cellsInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cells	ChEMBL	606	10	2	7	5.6	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)c2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL365005	126225	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cellsInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cells	ChEMBL	606	10	2	7	5.6	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)c2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL3350396	211477	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	15953838	67268	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-5-receptor (MC5R)Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-5-receptor (MC5R)	ChEMBL	602	10	2	7	5.9	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2003.09.026
	CHEMBL188146	67268	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-5-receptor (MC5R)Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-5-receptor (MC5R)	ChEMBL	602	10	2	7	5.9	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2003.09.026
	CHEMBL539306	67268	None	0	Human	Binding	pIC50	=	5.9	5.9	-	0	Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-5-receptor (MC5R)Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-5-receptor (MC5R)	ChEMBL	602	10	2	7	5.9	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2003.09.026
	122184575	122425	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600836	122425	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	44408252	140667	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	605	8	3	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCNC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL381503	140667	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	605	8	3	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCNC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	127053937	149051	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	502	11	2	4	4.3	CCC(CC)CN1CC[C@H](CNC(=O)/C=C/c2ccc(Cl)cc2)N[C@H](CCN2CCCCC2)C1=O	nan
	CHEMBL3942822	149051	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	502	11	2	4	4.3	CCC(CC)CN1CC[C@H](CNC(=O)/C=C/c2ccc(Cl)cc2)N[C@H](CCN2CCCCC2)C1=O	nan
	CHEMBL2371964	210159	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	57854102	148319	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@@H]1N[C@@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	CHEMBL3936968	148319	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@@H]1N[C@@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	44348144	157820	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)C1CSSCC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL408336	157820	None	0	Human	Binding	pIC50	=	4.8	4.8	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)C1CSSCC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	122184909	122552	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601427	122552	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL5081077	214715	None	0	Human	Binding	pIC50	=	5.8	5.8	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CN1C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]1CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	168282779	191169	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2ccccc2CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5188894	191169	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2ccccc2CSC1(C)C	10.1021/acs.jmedchem.1c01848
	1338	3805	None	43	Rat	Binding	pIC50	=	5.8	5.8	-	4	Evaluated for binding affinity against rat Melanocortin-5 receptor (rMC5R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against rat Melanocortin-5 receptor (rMC5R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	9938402	3805	None	43	Rat	Binding	pIC50	=	5.8	5.8	-	4	Evaluated for binding affinity against rat Melanocortin-5 receptor (rMC5R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against rat Melanocortin-5 receptor (rMC5R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	CHEMBL339053	3805	None	43	Rat	Binding	pIC50	=	5.8	5.8	-	4	Evaluated for binding affinity against rat Melanocortin-5 receptor (rMC5R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against rat Melanocortin-5 receptor (rMC5R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	CHEMBL190203	209062	None	0	Mouse	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12)C(C)=O	10.1021/jm0490033
	CHEMBL365794	212039	None	0	Mouse	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL3600920	211821	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	44347840	161922	None	0	Human	Binding	pIC50	=	7.8	7.8	-208	3	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0202526
	91932630	161922	None	0	Human	Binding	pIC50	=	7.8	7.8	-208	3	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0202526
	CHEMBL415333	161922	None	0	Human	Binding	pIC50	=	7.8	7.8	-208	3	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0202526
	CHEMBL1161316	208502	None	0	Human	Binding	pIC50	=	7.8	7.8	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	10.1021/jm0202526
	CHEMBL3600840	211815	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600832	211811	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	145973975	164655	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4216654	164655	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	44408189	168877	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	619	8	2	4	4.6	CN1CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)C1=O	10.1016/j.bmcl.2005.11.095
	CHEMBL438259	168877	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	619	8	2	4	4.6	CN1CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)C1=O	10.1016/j.bmcl.2005.11.095
	CHEMBL3349030	211403	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL5090670	215275	None	0	Human	Binding	pIC50	=	6.8	6.8	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	137636965	156214	None	0	Human	Binding	pIC50	=	4.8	4.8	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4064433	156214	None	0	Human	Binding	pIC50	=	4.8	4.8	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	145964837	164345	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	875	11	12	9	-0.5	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4212629	164345	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	875	11	12	9	-0.5	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL5087859	215121	None	0	Human	Binding	pIC50	=	6.8	6.8	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	118735100	118798	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	764	15	9	6	1.8	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(F)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421677	118798	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	764	15	9	6	1.8	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(F)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3600913	211820	None	0	Human	Binding	pIC50	=	5.8	5.8	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL5090946	215283	None	0	Human	Binding	pIC50	=	6.8	6.8	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44445085	97072	None	0	Human	Binding	pIC50	=	7.8	7.8	2	2	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	879	9	11	9	1.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL267265	97072	None	0	Human	Binding	pIC50	=	7.8	7.8	2	2	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	879	9	11	9	1.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	44408173	75399	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	640	8	2	5	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCCS2(=O)=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL203975	75399	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	640	8	2	5	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCCS2(=O)=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	44408276	75505	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	632	8	2	5	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL204308	75505	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	632	8	2	5	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	132938008	159511	None	0	Mouse	Binding	pIC50	=	5.8	5.8	-17	3	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4102048	159511	None	0	Mouse	Binding	pIC50	=	5.8	5.8	-17	3	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	138106885	166909	None	75	Human	Binding	pIC50	=	4.8	4.8	-3	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
	36314	166909	None	75	Human	Binding	pIC50	=	4.8	4.8	-3	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
	CHEMBL428647	166909	None	75	Human	Binding	pIC50	=	4.8	4.8	-3	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
	168296790	192344	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1163	17	13	12	3.0	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)C(C)(C)SCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5206941	192344	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1163	17	13	12	3.0	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)C(C)(C)SCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5075712	214392	None	0	Human	Binding	pIC50	=	6.8	6.8	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL5077095	214477	None	0	Human	Binding	pIC50	=	6.8	6.8	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL3601431	211825	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL5077144	214483	None	0	Human	Binding	pIC50	=	5.8	5.8	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	16132144	209277	None	36	Human	Binding	pIC50	=	7.8	7.8	-100	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	16133793	209277	None	36	Human	Binding	pIC50	=	7.8	7.8	-100	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	44273719	209277	None	36	Human	Binding	pIC50	=	7.8	7.8	-100	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	CHEMBL214332	209277	None	36	Human	Binding	pIC50	=	7.8	7.8	-100	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	16132144	209277	None	36	Human	Binding	pIC50	=	7.8	7.8	-100	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	16133793	209277	None	36	Human	Binding	pIC50	=	7.8	7.8	-100	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	44273719	209277	None	36	Human	Binding	pIC50	=	7.8	7.8	-100	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	CHEMBL214332	209277	None	36	Human	Binding	pIC50	=	7.8	7.8	-100	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	44408190	96921	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	606	8	2	5	4.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCOC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL265985	96921	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	606	8	2	5	4.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCOC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	71449047	78478	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL2111807	78478	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	44577510	188733	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	893	12	11	11	0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL504986	188733	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	893	12	11	11	0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	44408154	141360	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	668	8	2	5	5.1	CC1(C)CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)S1(=O)=O	10.1016/j.bmcl.2005.11.095
	CHEMBL383719	141360	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	668	8	2	5	5.1	CC1(C)CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)S1(=O)=O	10.1016/j.bmcl.2005.11.095
	CHEMBL3349030	211403	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	42630327	155869	None	0	Human	Binding	pIC50	=	5.7	5.7	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1119	32	19	14	-3.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(N)=O	10.1021/acs.jmedchem.8b00170
	CHEMBL4060381	155869	None	0	Human	Binding	pIC50	=	5.7	5.7	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1119	32	19	14	-3.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(N)=O	10.1021/acs.jmedchem.8b00170
	11993702	3591	None	18	Human	Binding	pIC50	=	5.7	5.7	-19	5	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	5416	3591	None	18	Human	Binding	pIC50	=	5.7	5.7	-19	5	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	9272	3591	None	18	Human	Binding	pIC50	=	5.7	5.7	-19	5	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	CHEMBL3301624	3591	None	18	Human	Binding	pIC50	=	5.7	5.7	-19	5	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	DB11700	3591	None	18	Human	Binding	pIC50	=	5.7	5.7	-19	5	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	10408	719	None	28	Human	Binding	pIC50	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	5329	719	None	28	Human	Binding	pIC50	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	9941379	719	None	28	Human	Binding	pIC50	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	CHEMBL2070241	719	None	28	Human	Binding	pIC50	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	DB11653	719	None	28	Human	Binding	pIC50	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	10408	719	None	28	Human	Binding	pIC50	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	5329	719	None	28	Human	Binding	pIC50	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	9941379	719	None	28	Human	Binding	pIC50	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	CHEMBL2070241	719	None	28	Human	Binding	pIC50	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	DB11653	719	None	28	Human	Binding	pIC50	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	CHEMBL5083551	214867	None	0	Human	Binding	pIC50	=	6.7	6.7	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL5091236	215297	None	0	Human	Binding	pIC50	=	5.7	5.7	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL190427	209063	None	0	Mouse	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12)C(C)=O	10.1021/jm0490033
	CHEMBL190732	209065	None	0	Mouse	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL191063	209077	None	0	Mouse	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL2371835	210135	None	0	Mouse	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	168273822	190568	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5180152	190568	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL2371712	210107	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL2371971	210166	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](c2ccccc2)NC1=O	10.1021/jm0614275
	CHEMBL502300	214150	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	1324	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	16154396	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	16197727	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	44285019	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	57514683	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	91898441	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL441738	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	DB04931	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	1324	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	16154396	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	16197727	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	44285019	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	57514683	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	91898441	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	CHEMBL441738	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	DB04931	302	None	25	Human	Binding	pIC50	=	8.7	8.7	-6	4	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	CHEMBL413573	213073	None	0	Human	Binding	pIC50	=	8.7	8.7	1	2	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](C(C)C)NC1=O	10.1021/jm0510326
	CHEMBL204263	209161	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](CCCN=C(N)N)NC1=O	10.1021/jm0510326
	CHEMBL425591	213336	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0510326
	CHEMBL503229	214161	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm801300c
	CHEMBL443071	213918	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL500743	214122	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	CHEMBL2371967	210162	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2C1=O	10.1021/jm0614275
	122184637	122434	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600918	122434	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL2371963	210158	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm0614275
	145973779	164730	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	929	11	12	9	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4217528	164730	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	929	11	12	9	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	44408155	140551	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	656	10	2	5	4.9	CC(C)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O	10.1016/j.bmcl.2005.11.095
	CHEMBL381125	140551	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	656	10	2	5	4.9	CC(C)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O	10.1016/j.bmcl.2005.11.095
	CHEMBL439691	213846	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	44347927	157274	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1443	31	14	21	-1.9	CC(=O)[C@@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL407680	157274	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1443	31	14	21	-1.9	CC(=O)[C@@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL1201469	14505	None	0	Human	Binding	pIC50	=	5.7	5.7	-1	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL		None	None	None		None	nan
	CHEMBL5076315	214426	None	0	Human	Binding	pIC50	=	6.7	6.7	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44448590	95597	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	571	7	1	4	6.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(OC)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL257759	95597	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	571	7	1	4	6.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(OC)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	44417555	97238	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]NDP-alphaMSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I]NDP-alphaMSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	896	15	9	10	1.2	CC(=O)N[C@H]1CSSC[C@@H](C(=O)N(CCCCN=C(N)N)[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm060768f
	CHEMBL268684	97238	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]NDP-alphaMSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I]NDP-alphaMSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	896	15	9	10	1.2	CC(=O)N[C@H]1CSSC[C@@H](C(=O)N(CCCCN=C(N)N)[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm060768f
	CHEMBL2372588	210270	None	0	Human	Binding	pIC50	=	7.7	7.7	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2Cc3ccccc3N2C1=O	10.1021/jm0202526
	145967155	164241	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4211275	164241	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	44408388	140321	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	646	8	2	5	5.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CCC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL380635	140321	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	646	8	2	5	5.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CCC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	24774519	94852	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	911	9	10	8	2.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL253788	94852	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	911	9	10	8	2.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL509582	215544	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm801300c
	44408275	75417	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	620	8	2	5	5.1	C[C@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL204078	75417	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	620	8	2	5	5.1	C[C@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL409144	212745	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](CC(=O)O)NC1=O	10.1021/jm0510326
	1334	1500	None	7	Human	Binding	pIC50	=	5.7	5.7	-3	3	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	16133814	1500	None	7	Human	Binding	pIC50	=	5.7	5.7	-3	3	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL437050	1500	None	7	Human	Binding	pIC50	=	5.7	5.7	-3	3	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL3600841	211816	None	0	Human	Binding	pIC50	=	5.7	5.7	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	4189	206920	None	96	Human	Binding	pIC50	=	4.7	4.7	-61	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206920	None	96	Human	Binding	pIC50	=	4.7	4.7	-61	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206920	None	96	Human	Binding	pIC50	=	4.7	4.7	-61	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	2247	505	None	81	Human	Binding	pIC50	=	5.6	5.6	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	505	None	81	Human	Binding	pIC50	=	5.6	5.6	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	505	None	81	Human	Binding	pIC50	=	5.6	5.6	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	505	None	81	Human	Binding	pIC50	=	5.6	5.6	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	505	None	81	Human	Binding	pIC50	=	5.6	5.6	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	1323	2686	None	55	Human	Binding	pIC50	=	7.6	7.6	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00170
	92432	2686	None	55	Human	Binding	pIC50	=	7.6	7.6	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00170
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	7.6	7.6	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00170
	24774438	94853	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	816	9	10	9	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)c2nccnc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL253789	94853	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	816	9	10	9	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)c2nccnc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	6918849	122962	None	1	Human	Binding	pIC50	=	7.6	7.6	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	620	7	3	4	5.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2CCc3ccccc3[C@@H]2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL360818	122962	None	1	Human	Binding	pIC50	=	7.6	7.6	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	620	7	3	4	5.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2CCc3ccccc3[C@@H]2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL2371973	210168	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(Cc3ccccc3)cc2)NC(=O)[C@@H]2CC3CCCCC3N2C1=O	10.1021/jm0614275
	CHEMBL2115441	209266	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	6918813	131369	None	3	Human	Binding	pIC50	=	5.6	5.6	-	0	Concentration for 50% inhibition of human melanocortin-5 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandConcentration for 50% inhibition of human melanocortin-5 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL368876	131369	None	3	Human	Binding	pIC50	=	5.6	5.6	-	0	Concentration for 50% inhibition of human melanocortin-5 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandConcentration for 50% inhibition of human melanocortin-5 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	16725559	94987	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	591	6	1	3	7.5	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL254757	94987	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	591	6	1	3	7.5	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2008.04.049
	10077258	15029	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	596	8	0	5	4.5	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)S(C)(=O)=O	10.1016/j.bmcl.2010.06.038
	CHEMBL1209253	15029	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	596	8	0	5	4.5	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)S(C)(=O)=O	10.1016/j.bmcl.2010.06.038
	CHEMBL389674	212431	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	1334	1500	None	7	Human	Binding	pIC50	=	5.6	5.6	-3	3	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	16133814	1500	None	7	Human	Binding	pIC50	=	5.6	5.6	-3	3	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	CHEMBL437050	1500	None	7	Human	Binding	pIC50	=	5.6	5.6	-3	3	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	137659790	159320	None	0	Human	Binding	pIC50	=	4.6	4.6	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4099889	159320	None	0	Human	Binding	pIC50	=	4.6	4.6	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	122184914	122557	None	0	Human	Binding	pIC50	=	6.6	6.6	-	1	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1144	17	9	11	1.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601432	122557	None	0	Human	Binding	pIC50	=	6.6	6.6	-	1	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1144	17	9	11	1.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	1323	2686	None	55	Human	Binding	pIC50	=	7.6	7.6	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	92432	2686	None	55	Human	Binding	pIC50	=	7.6	7.6	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	7.6	7.6	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	CHEMBL228194	209451	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	71456219	78745	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL2112603	78745	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	1016	3745	None	78	Human	Binding	pIC50	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3745	None	78	Human	Binding	pIC50	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3745	None	78	Human	Binding	pIC50	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3745	None	78	Human	Binding	pIC50	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3745	None	78	Human	Binding	pIC50	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3745	None	78	Human	Binding	pIC50	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL2221249	209441	None	0	Human	Binding	pIC50	=	6.6	6.6	-1	3	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL		None	None	None		CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O	nan
	122184635	122432	None	0	Human	Binding	pIC50	=	6.6	6.6	-3	4	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600916	122432	None	0	Human	Binding	pIC50	=	6.6	6.6	-3	4	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL5091245	215298	None	0	Human	Binding	pIC50	=	5.6	5.6	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44445083	154303	None	0	Human	Binding	pIC50	=	7.6	7.6	-	1	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	953	9	10	9	2.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL398665	154303	None	0	Human	Binding	pIC50	=	7.6	7.6	-	1	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	953	9	10	9	2.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL3600834	211813	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	155544852	174937	None	0	Mouse	Binding	pIC50	=	5.6	5.6	-19	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	977	12	10	10	-0.5	CC(C)[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4565367	174937	None	0	Mouse	Binding	pIC50	=	5.6	5.6	-19	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	977	12	10	10	-0.5	CC(C)[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL426756	213347	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	44348200	160194	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1511	33	16	22	-1.7	CC(=O)C1C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)CSSC1(C)C	10.1021/jm030111j
	CHEMBL410949	160194	None	0	Human	Binding	pIC50	=	4.6	4.6	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1511	33	16	22	-1.7	CC(=O)C1C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)CSSC1(C)C	10.1021/jm030111j
	44448631	95068	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL255286	95068	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	49862425	15058	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	570	9	0	5	4.0	CC(C)CC(CN(C(C)C)S(C)(=O)=O)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1	10.1016/j.bmcl.2010.06.038
	CHEMBL1209382	15058	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	570	9	0	5	4.0	CC(C)CC(CN(C(C)C)S(C)(=O)=O)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1	10.1016/j.bmcl.2010.06.038
	137631599	156524	None	0	Human	Binding	pIC50	=	6.6	6.6	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4067967	156524	None	0	Human	Binding	pIC50	=	6.6	6.6	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	2750	204059	None	76	Human	Binding	pIC50	=	4.5	4.5	-15	12	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	CHEMBL7002	204059	None	76	Human	Binding	pIC50	=	4.5	4.5	-15	12	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	44431511	88064	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Displacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cells	ChEMBL	1004	14	12	10	0.3	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	CHEMBL234629	88064	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Displacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cells	ChEMBL	1004	14	12	10	0.3	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	155548853	173807	None	0	Mouse	Binding	pIC50	=	4.5	4.5	-50	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	1005	13	10	10	-0.6	CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4538274	173807	None	0	Mouse	Binding	pIC50	=	4.5	4.5	-50	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	1005	13	10	10	-0.6	CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL414778	213154	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL3600833	211812	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL413439	213068	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	CHEMBL204864	209164	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCC)NC1=O	10.1021/jm0510326
	168278924	191064	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5187368	191064	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	127053935	144183	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	602	11	2	4	6.2	O=C(NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCCN2CCCCC2)N1)c1ccc2ccccc2c1	nan
	CHEMBL3904191	144183	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	602	11	2	4	6.2	O=C(NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCCN2CCCCC2)N1)c1ccc2ccccc2c1	nan
	CHEMBL3752534	212214	None	1	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL1775066	208879	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma counting	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1016/j.bmcl.2011.03.019
	CHEMBL382369	212303	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0510326
	CHEMBL5075506	214377	None	0	Human	Binding	pIC50	=	5.5	5.5	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	10282847	122963	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	634	7	3	4	5.9	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2CCc3ccccc3[C@@]2(C)N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL360819	122963	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	634	7	3	4	5.9	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2CCc3ccccc3[C@@]2(C)N)CC1	10.1016/j.bmcl.2005.05.012
	127053935	144183	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	602	11	2	4	6.2	O=C(NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCCN2CCCCC2)N1)c1ccc2ccccc2c1	nan
	CHEMBL3904191	144183	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	602	11	2	4	6.2	O=C(NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCCN2CCCCC2)N1)c1ccc2ccccc2c1	nan
	71459938	78979	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL2113043	78979	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL189991	209059	None	0	Mouse	Binding	pIC50	=	5.5	5.5	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL275999	210824	None	0	Mouse	Binding	pIC50	=	5.5	5.5	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12)C(C)=O	10.1021/jm0490033
	CHEMBL370321	212165	None	0	Mouse	Binding	pIC50	=	5.5	5.5	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	1338	3805	None	43	Human	Binding	pIC50	=	6.5	6.5	-154	4	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.05.012
	9938402	3805	None	43	Human	Binding	pIC50	=	6.5	6.5	-154	4	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.05.012
	CHEMBL339053	3805	None	43	Human	Binding	pIC50	=	6.5	6.5	-154	4	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.05.012
	1338	3805	None	43	Human	Binding	pIC50	=	6.5	6.5	-154	4	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	9938402	3805	None	43	Human	Binding	pIC50	=	6.5	6.5	-154	4	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	CHEMBL339053	3805	None	43	Human	Binding	pIC50	=	6.5	6.5	-154	4	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	1338	3805	None	43	Human	Binding	pIC50	=	6.5	6.5	-154	4	Evaluated for binding affinity against human melanocortin 5 (hMC5R) receptor by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against human melanocortin 5 (hMC5R) receptor by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	9938402	3805	None	43	Human	Binding	pIC50	=	6.5	6.5	-154	4	Evaluated for binding affinity against human melanocortin 5 (hMC5R) receptor by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against human melanocortin 5 (hMC5R) receptor by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	CHEMBL339053	3805	None	43	Human	Binding	pIC50	=	6.5	6.5	-154	4	Evaluated for binding affinity against human melanocortin 5 (hMC5R) receptor by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against human melanocortin 5 (hMC5R) receptor by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	1334	1500	None	7	Human	Binding	pIC50	=	6.5	6.5	-3	3	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	16133814	1500	None	7	Human	Binding	pIC50	=	6.5	6.5	-3	3	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL437050	1500	None	7	Human	Binding	pIC50	=	6.5	6.5	-3	3	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		None	10.1021/jm049579s
	10210964	67241	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	606	7	3	4	5.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3C2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL187990	67241	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	606	7	3	4	5.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3C2N)CC1	10.1016/j.bmcl.2005.05.012
	16157270	212551	None	14	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL405282	212551	None	14	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	44577520	188822	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	904	12	10	11	1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm701181n
	CHEMBL506274	188822	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	904	12	10	11	1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm701181n
	CHEMBL376614	212250	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(O)cc2)N(CC)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	16157270	212551	None	14	Human	Binding	pIC50	=	6.5	6.5	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	CHEMBL405282	212551	None	14	Human	Binding	pIC50	=	6.5	6.5	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	CHEMBL3600843	211818	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3349030	211403	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	57853943	146522	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@H]1N[C@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	CHEMBL3922633	146522	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@H]1N[C@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	CHEMBL227239	209449	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2cc3ccccc3s2)N(CC)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	155561116	174971	None	0	Mouse	Binding	pIC50	=	4.4	4.4	-10	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	964	11	11	11	-1.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4566163	174971	None	0	Mouse	Binding	pIC50	=	4.4	4.4	-10	4	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 5 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	964	11	11	11	-1.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	145990599	166853	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL	710	17	7	6	2.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4285535	166853	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL	710	17	7	6	2.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	118735102	118800	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	707	15	8	6	1.1	CC(=O)N[C@H]1Cc2ccccc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421679	118800	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	707	15	8	6	1.1	CC(=O)N[C@H]1Cc2ccccc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	2683	102886	None	25	Human	Binding	pIC50	=	5.4	5.4	-478	16	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL305906	102886	None	25	Human	Binding	pIC50	=	5.4	5.4	-478	16	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL334255	102886	None	25	Human	Binding	pIC50	=	5.4	5.4	-478	16	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	24858481	189107	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	909	12	10	10	2.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL510234	189107	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	909	12	10	10	2.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	145971389	164631	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4216242	164631	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	11249545	66202	None	0	Human	Binding	pIC50	=	6.4	6.4	61	4	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	529	6	3	3	5.6	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)[C@H](C)CN1	10.1021/jm0400496
	CHEMBL184432	66202	None	0	Human	Binding	pIC50	=	6.4	6.4	61	4	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	529	6	3	3	5.6	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)[C@H](C)CN1	10.1021/jm0400496
	11364326	66684	None	0	Human	Binding	pIC50	=	6.4	6.4	27	3	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	515	6	3	3	5.2	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	CHEMBL185455	66684	None	0	Human	Binding	pIC50	=	6.4	6.4	27	3	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	515	6	3	3	5.2	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	CHEMBL5094168	215477	None	0	Human	Binding	pIC50	=	6.4	6.4	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	122184638	122435	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600919	122435	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	25444	155649	None	6	Human	Binding	pIC50	=	5.4	5.4	-	1	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	1229	14	17	29	-6.5	C[C@H]1[C@H]2[C@@H](O[C@]13CC[C@@H](C)CO3)[C@@H](O)[C@H]1[C@@H]3CC[C@H]4C[C@@H](O[C@@H]5O[C@H](CO)[C@H](O[C@@H]6O[C@H](CO)C(O)[C@H](O[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O[C@@H]6O[C@H](CO)[C@H](O)[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)C[C@]4(C)[C@H]3CC[C@@]12C	nan
	CHEMBL404811	155649	None	6	Human	Binding	pIC50	=	5.4	5.4	-	1	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	1229	14	17	29	-6.5	C[C@H]1[C@H]2[C@@H](O[C@]13CC[C@@H](C)CO3)[C@@H](O)[C@H]1[C@@H]3CC[C@H]4C[C@@H](O[C@@H]5O[C@H](CO)[C@H](O[C@@H]6O[C@H](CO)C(O)[C@H](O[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O[C@@H]6O[C@H](CO)[C@H](O)[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)C[C@]4(C)[C@H]3CC[C@@]12C	nan
	122184636	122433	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600917	122433	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL375947	212230	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	8447	188947	None	84	Human	Binding	pIC50	=	5.4	5.4	-50	13	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
	CHEMBL508112	188947	None	84	Human	Binding	pIC50	=	5.4	5.4	-50	13	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
	3198	205511	None	76	Human	Binding	pIC50	=	4.4	4.4	-81	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205511	None	76	Human	Binding	pIC50	=	4.4	4.4	-81	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205511	None	76	Human	Binding	pIC50	=	4.4	4.4	-81	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL371610	212168	None	0	Mouse	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12)C(C)=O	10.1021/jm0490033
	1323	2686	None	55	Human	Binding	pIC50	=	8.4	8.4	-	3	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	92432	2686	None	55	Human	Binding	pIC50	=	8.4	8.4	-	3	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	8.4	8.4	-	3	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	CHEMBL1161320	208504	None	0	Human	Binding	pIC50	=	8.4	8.4	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CC2)NC1=O	10.1021/jm0202526
	44422999	168853	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL	1040	15	9	10	3.0	CCCC[C@H](NC(C)=O)C(=O)C[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	CHEMBL438118	168853	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL	1040	15	9	10	3.0	CCCC[C@H](NC(C)=O)C(=O)C[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	1323	2686	None	55	Human	Binding	pIC50	=	8.4	8.4	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/ml500436s
	92432	2686	None	55	Human	Binding	pIC50	=	8.4	8.4	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/ml500436s
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	8.4	8.4	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/ml500436s
	1323	2686	None	55	Human	Binding	pIC50	=	8.4	8.4	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma counting	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	92432	2686	None	55	Human	Binding	pIC50	=	8.4	8.4	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma counting	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	8.4	8.4	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma counting	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	163196518	192127	None	2	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5203580	192127	None	2	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL1161318	208503	None	0	Human	Binding	pIC50	=	8.3	8.3	-	2	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCCC2)NC1=O	10.1021/jm0202526
	44397455	123841	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	620	7	3	4	5.2	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3CC2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL362523	123841	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	620	7	3	4	5.2	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3CC2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL381739	212290	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	10.1021/jm0510326
	57854192	153047	None	0	Mouse	Binding	pIC50	=	5.4	5.4	-	0	Radioligand Binding Assay: Radioligand binding and cAMP assays were also conducted using membranes and cells expressing MC5R cloned from other species (mouse MC5R membranes were obtained from Euroscreen; canine, rhesus monkey, cyno monkey and guinea pig MC5 receptors were cloned and expressed from cDNA libraries and transiently transfected as described in Examples 107 and 109. Plasma membranes from the cells were tested in the radioligand assay as in Example 102.Radioligand Binding Assay: Radioligand binding and cAMP assays were also conducted using membranes and cells expressing MC5R cloned from other species (mouse MC5R membranes were obtained from Euroscreen; canine, rhesus monkey, cyno monkey and guinea pig MC5 receptors were cloned and expressed from cDNA libraries and transiently transfected as described in Examples 107 and 109. Plasma membranes from the cells were tested in the radioligand assay as in Example 102.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@H]1N[C@@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	CHEMBL3975851	153047	None	0	Mouse	Binding	pIC50	=	5.4	5.4	-	0	Radioligand Binding Assay: Radioligand binding and cAMP assays were also conducted using membranes and cells expressing MC5R cloned from other species (mouse MC5R membranes were obtained from Euroscreen; canine, rhesus monkey, cyno monkey and guinea pig MC5 receptors were cloned and expressed from cDNA libraries and transiently transfected as described in Examples 107 and 109. Plasma membranes from the cells were tested in the radioligand assay as in Example 102.Radioligand Binding Assay: Radioligand binding and cAMP assays were also conducted using membranes and cells expressing MC5R cloned from other species (mouse MC5R membranes were obtained from Euroscreen; canine, rhesus monkey, cyno monkey and guinea pig MC5 receptors were cloned and expressed from cDNA libraries and transiently transfected as described in Examples 107 and 109. Plasma membranes from the cells were tested in the radioligand assay as in Example 102.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@H]1N[C@@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	137655905	158826	None	0	Human	Binding	pIC50	=	5.4	5.4	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1666	20	22	21	-3.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4094606	158826	None	0	Human	Binding	pIC50	=	5.4	5.4	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1666	20	22	21	-3.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	137640703	157095	None	0	Human	Binding	pIC50	=	5.4	5.4	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4074479	157095	None	0	Human	Binding	pIC50	=	5.4	5.4	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	168272745	190521	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2ccc(cc2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5179534	190521	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2ccc(cc2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	122184911	122554	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601429	122554	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	1323	2686	None	55	Human	Binding	pIC50	=	7.4	7.4	-	3	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	92432	2686	None	55	Human	Binding	pIC50	=	7.4	7.4	-	3	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	7.4	7.4	-	3	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	9808801	60807	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	599	8	3	4	5.0	CC[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](CC)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1761871	60807	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	599	8	3	4	5.0	CC[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](CC)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL383250	212310	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCC(=O)O)NC1=O	10.1021/jm0510326
	145966490	164360	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	839	11	12	9	-1.2	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4212762	164360	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	839	11	12	9	-1.2	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	24857886	155246	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	591	6	1	3	7.2	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL402769	155246	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	591	6	1	3	7.2	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmcl.2008.04.049
	68617	205525	None	62	Human	Binding	pIC50	=	5.3	5.3	-21	26	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL1709	205525	None	62	Human	Binding	pIC50	=	5.3	5.3	-21	26	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL809	205525	None	62	Human	Binding	pIC50	=	5.3	5.3	-21	26	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	145980719	166494	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL	642	17	7	6	1.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4278563	166494	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL	642	17	7	6	1.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	168274393	190103	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccccc2CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5172938	190103	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccccc2CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	11341045	66164	None	0	Human	Binding	pIC50	=	6.3	6.3	22	4	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	501	6	3	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCNCC2)cc1	10.1021/jm0400496
	CHEMBL184275	66164	None	0	Human	Binding	pIC50	=	6.3	6.3	22	4	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	501	6	3	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCNCC2)cc1	10.1021/jm0400496
	CHEMBL3600835	211814	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL438920	213807	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL2371970	210165	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](C2CCCCC2)NC1=O	10.1021/jm0614275
	CHEMBL438294	213764	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	CHEMBL203602	209158	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm0510326
	44206252	149330	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@@H]1N[C@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	CHEMBL3945076	149330	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@@H]1N[C@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	CHEMBL190080	209060	None	0	Mouse	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL2371828	210131	None	0	Mouse	Binding	pIC50	=	5.3	5.3	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)Cc1ccccc1)C(C)=O	10.1021/jm0490033
	168273291	190530	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1163	17	13	12	3.0	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)C(C)(C)SCc2ccccc2CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5179637	190530	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1163	17	13	12	3.0	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)C(C)(C)SCc2ccccc2CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5080784	214704	None	0	Human	Binding	pIC50	=	6.3	6.3	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44445084	160737	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	829	9	11	9	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL411391	160737	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	829	9	11	9	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	11341046	66878	None	0	Human	Binding	pIC50	=	6.3	6.3	57	4	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	501	7	4	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N\C2CCNC2)NC2CCCCC2)cc1	10.1021/jm0400496
	CHEMBL186339	66878	None	0	Human	Binding	pIC50	=	6.3	6.3	57	4	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	501	7	4	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N\C2CCNC2)NC2CCCCC2)cc1	10.1021/jm0400496
	11237444	127463	None	0	Human	Binding	pIC50	=	6.3	6.3	245	3	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	503	8	4	3	5.4	CC(C)(N)C/N=C(\Nc1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1	10.1021/jm0400496
	CHEMBL366042	127463	None	0	Human	Binding	pIC50	=	6.3	6.3	245	3	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	503	8	4	3	5.4	CC(C)(N)C/N=C(\Nc1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1	10.1021/jm0400496
	10304776	78977	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	634	7	3	4	6.1	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2CCCc3ccccc3C2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL2113041	78977	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	634	7	3	4	6.1	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2CCCc3ccccc3C2N)CC1	10.1016/j.bmcl.2005.05.012
	54587278	60816	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	587	6	3	4	4.7	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1762009	60816	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	587	6	3	4	4.7	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	44366171	121292	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm0202526
	CHEMBL358015	121292	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity against human Melanocortin 5 receptorBinding affinity against human Melanocortin 5 receptor	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm0202526
	CHEMBL410795	212840	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL5080489	214687	None	0	Human	Binding	pIC50	=	6.3	6.3	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL263948	210597	None	1	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm960840h
	16132144	209277	None	36	Human	Binding	pIC50	=	6.3	6.3	-100	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm960845e
	16133793	209277	None	36	Human	Binding	pIC50	=	6.3	6.3	-100	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm960845e
	44273719	209277	None	36	Human	Binding	pIC50	=	6.3	6.3	-100	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm960845e
	CHEMBL214332	209277	None	36	Human	Binding	pIC50	=	6.3	6.3	-100	4	Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm960845e
	57854192	153047	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@H]1N[C@@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	CHEMBL3975851	153047	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@H]1N[C@@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	24858479	172607	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	915	10	10	10	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL449124	172607	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	915	10	10	10	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	57854192	153047	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@H]1N[C@@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	CHEMBL3975851	153047	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@H]1N[C@@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	CHEMBL3349030	211403	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL3600922	211823	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	24858629	195467	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	853	10	9	10	1.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL552520	195467	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	853	10	9	10	1.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	137660993	159445	None	0	Human	Binding	pIC50	=	7.2	7.2	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4101216	159445	None	0	Human	Binding	pIC50	=	7.2	7.2	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	145948876	167481	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL4299441	167481	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL5078687	214578	None	0	Human	Binding	pIC50	=	6.2	6.2	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL455070	213997	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm801300c
	122184634	122431	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600915	122431	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	122184576	122426	None	0	Human	Binding	pIC50	=	8.2	8.2	-	1	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600837	122426	None	0	Human	Binding	pIC50	=	8.2	8.2	-	1	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	122184499	122391	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1088	17	13	11	0.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600737	122391	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1088	17	13	11	0.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600912	211819	None	0	Human	Binding	pIC50	=	8.2	8.2	-	1	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	122184633	122430	None	0	Human	Binding	pIC50	=	8.2	8.2	-	1	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600914	122430	None	0	Human	Binding	pIC50	=	8.2	8.2	-	1	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600736	211810	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	49862377	15039	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	654	9	0	6	6.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cnn(C(C)C)c1	10.1016/j.bmcl.2010.06.038
	CHEMBL1209320	15039	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	654	9	0	6	6.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cnn(C(C)C)c1	10.1016/j.bmcl.2010.06.038
	145976863	163756	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	879	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4205548	163756	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	879	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	44408253	140342	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	650	10	2	5	6.1	CCOC(=O)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)C(C)C	10.1016/j.bmcl.2005.11.095
	CHEMBL380727	140342	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	650	10	2	5	6.1	CCOC(=O)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)C(C)C	10.1016/j.bmcl.2005.11.095
	11477853	66892	None	0	Human	Binding	pIC50	=	6.2	6.2	38	3	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	515	7	3	3	5.2	CNC1CCN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)C1	10.1021/jm0400496
	CHEMBL186439	66892	None	0	Human	Binding	pIC50	=	6.2	6.2	38	3	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	515	7	3	3	5.2	CNC1CCN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)C1	10.1021/jm0400496
	CHEMBL5094215	215479	None	0	Human	Binding	pIC50	=	6.2	6.2	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL190953	209075	None	0	Mouse	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL364711	212030	None	0	Mouse	Binding	pIC50	=	5.2	5.2	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	118735099	118797	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	746	15	9	6	1.6	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421676	118797	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	746	15	9	6	1.6	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL411359	212877	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	10304547	168250	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	620	7	3	4	5.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2CCc3ccccc3[C@H]2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL433764	168250	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells	ChEMBL	620	7	3	4	5.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2CCc3ccccc3[C@H]2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL11359	9778	None	0	Human	Binding	pIC50	=	5.2	5.2	-2	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL		None	None	None		None	nan
	10188529	126779	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	CN1C[C@H]2CC[C@@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2	10.1016/j.bmcl.2005.05.109
	CHEMBL365401	126779	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	CN1C[C@H]2CC[C@@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2	10.1016/j.bmcl.2005.05.109
	44448629	167461	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL429854	167461	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL2310901	209496	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	10257242	15028	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	560	7	0	4	5.1	CC(=O)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	CHEMBL1209252	15028	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	560	7	0	4	5.1	CC(=O)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	137636677	156098	None	0	Human	Binding	pIC50	=	5.2	5.2	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4063111	156098	None	0	Human	Binding	pIC50	=	5.2	5.2	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	44448479	155369	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	573	6	1	3	7.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL403420	155369	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity to human MC5RBinding affinity to human MC5R	ChEMBL	573	6	1	3	7.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL5090285	215251	None	0	Human	Binding	pIC50	=	6.2	6.2	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL263822	210588	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC1=O	10.1021/jm0510326
	168295131	192240	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5205283	192240	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	71456245	78974	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor	ChEMBL	608	9	2	6	6.2	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL2113039	78974	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor	ChEMBL	608	9	2	6	6.2	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	1323	2686	None	55	Human	Binding	pIC50	=	8.2	8.2	-	3	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	92432	2686	None	55	Human	Binding	pIC50	=	8.2	8.2	-	3	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	8.2	8.2	-	3	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	CHEMBL2371969	210164	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](C(C)C)NC1=O	10.1021/jm0614275
	CHEMBL393075	212460	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2007.02.020
	1323	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm070461w
	92432	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm070461w
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm070461w
	1323	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	92432	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	1323	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	92432	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	1323	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I]NDP-alphaMSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I]NDP-alphaMSH from human MC5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm060768f
	92432	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I]NDP-alphaMSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I]NDP-alphaMSH from human MC5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm060768f
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I]NDP-alphaMSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I]NDP-alphaMSH from human MC5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm060768f
	1323	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm801300c
	92432	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm801300c
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm801300c
	1323	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0510326
	92432	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0510326
	CHEMBL430239	2686	None	55	Human	Binding	pIC50	=	8.1	8.1	-	3	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0510326
	11375764	66687	None	0	Human	Binding	pIC50	=	7.2	7.2	398	3	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	515	6	3	3	5.2	C[C@@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	CHEMBL185469	66687	None	0	Human	Binding	pIC50	=	7.2	7.2	398	3	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	515	6	3	3	5.2	C[C@@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	CHEMBL380638	212269	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Inhibitory activity against hMC5R transfected in HEK293 cellsInhibitory activity against hMC5R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCC)NC1=O	10.1021/jm0510326
	118735101	118799	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	824	15	9	6	2.4	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(Br)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421678	118799	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	824	15	9	6	2.4	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(Br)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL2371972	210167	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](CC2CCC(C3CCCCC3)CC2)NC(=O)[C@H]2CC3CCCCC3N2C1=O	10.1021/jm0614275
	137641157	157062	None	0	Human	Binding	pIC50	=	6.2	6.2	-	1	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1666	20	22	21	-3.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4074074	157062	None	0	Human	Binding	pIC50	=	6.2	6.2	-	1	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1666	20	22	21	-3.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	137653925	158605	None	0	Human	Binding	pIC50	=	5.2	5.2	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4092141	158605	None	0	Human	Binding	pIC50	=	5.2	5.2	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL2112008	209224	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL5093939	215456	None	0	Human	Binding	pIC50	=	6.1	6.1	-	1	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	71456220	78746	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1483	33	16	22	-2.5	CC(=O)[C@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL2112604	78746	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1483	33	16	22	-2.5	CC(=O)[C@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	137660671	159216	None	0	Human	Binding	pIC50	=	6.1	6.1	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1708	20	19	21	-2.8	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4098785	159216	None	0	Human	Binding	pIC50	=	6.1	6.1	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1708	20	19	21	-2.8	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	44577514	172453	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	943	12	11	11	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL448081	172453	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	943	12	11	11	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	2726	918	None	68	Human	Binding	pIC50	=	5.1	5.1	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	918	None	68	Human	Binding	pIC50	=	5.1	5.1	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	918	None	68	Human	Binding	pIC50	=	5.1	5.1	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	918	None	68	Human	Binding	pIC50	=	5.1	5.1	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	918	None	68	Human	Binding	pIC50	=	5.1	5.1	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL3349030	211403	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	168295644	192310	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccccc2CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5206336	192310	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccccc2CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL227833	209450	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	24774358	154902	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	811	9	10	8	-0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)/C=C\C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL400866	154902	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	811	9	10	8	-0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)/C=C\C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL188459	209055	None	0	Mouse	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL191120	209078	None	0	Mouse	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from mouse melanocortin receptor-5 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	122184910	122553	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601428	122553	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	44408286	140666	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	634	8	2	5	5.5	CC1(C)COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL381501	140666	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	634	8	2	5	5.5	CC1(C)COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	9958649	124355	None	0	Human	Binding	pIC50	=	7.1	7.1	53	3	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	529	6	3	3	5.6	CC1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC(C)N1	10.1021/jm0400496
	CHEMBL363730	124355	None	0	Human	Binding	pIC50	=	7.1	7.1	53	3	Inhibition of human Melanocortin 5 receptorInhibition of human Melanocortin 5 receptor	ChEMBL	529	6	3	3	5.6	CC1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC(C)N1	10.1021/jm0400496
	137641398	158314	None	0	Human	Binding	pIC50	=	6.1	6.1	-	1	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4089162	158314	None	0	Human	Binding	pIC50	=	6.1	6.1	-	1	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	11753695	8391	None	7	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	599	4	1	3	6.7	CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21	10.1016/j.bmcl.2010.02.058
	CHEMBL1093304	8391	None	7	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells	ChEMBL	599	4	1	3	6.7	CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21	10.1016/j.bmcl.2010.02.058
	44397410	124357	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cellsInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cells	ChEMBL	620	10	2	7	6.0	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)c2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL363740	124357	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cellsInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cells	ChEMBL	620	10	2	7	6.0	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)c2=O)cc1	10.1016/j.bmcl.2005.06.033
	52918026	60806	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1761870	60806	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL3349030	211403	None	0	Human	Binding	pIC50	=	5.1	5.1	-	0	Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsBinding affinity for Human Melanocortin 5 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	137658158	159715	None	0	Human	Binding	pIC50	=	5.1	5.1	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1714	21	22	21	-3.6	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4104465	159715	None	0	Human	Binding	pIC50	=	5.1	5.1	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1714	21	22	21	-3.6	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	44431513	145807	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cells	ChEMBL	1054	14	12	10	1.4	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	CHEMBL391704	145807	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC5R expressed in HEK293 cells	ChEMBL	1054	14	12	10	1.4	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	44445082	154300	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	799	9	10	8	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL398664	154300	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	799	9	10	8	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL3600921	211822	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL5087839	215118	None	0	Human	Binding	pIC50	=	7.1	7.1	-	3	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	127053936	152238	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	598	11	2	4	5.7	O=C(/C=C/c1ccc(Cl)cc1)NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCN2CCCCC2)N1	nan
	CHEMBL3968918	152238	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.Radioligand Binding Assay: Assessments of compound binding to human MC5R (hMC5R)) by displacement of an 125I-labeled NDP-MSH receptor ligand peptide were performed essentially as described in the data sheets produced by Perkin Elmer to accompany their frozen hMC5R membranes (Perkin Elmer catalog number RBXMC5M400UA). [125I] NDP-MSH: Radiolabeled in House and Purified by HPLC: Na125I (0.5 mCi, 17.4 Ci/mg) was added to 50 μL sodium phosphate (50 mM, pH 7.4) in an eppendorf tube precoated with IODOGEN. After incubation for 10 mins the phosphate buffer containing the iodine was added to NDP-MSH (10 μl at 1 mg/mL) in a separate eppendorf tube. This was incubated for a further 10 mins. The iodinated NDP-MSH was purified by HPLC on a Zorbax SB 300 column using solvent A: 0.05% TFA and solvent B: 90% acetonitrile 0.045% TFA with a linear gradient, 0-67% B over 60 mins. The 125I NDP-MSH eluted at 52 mins after the unlabeled starting material (48 min) and was counted and stored in the freezer. It was used within 48 hrs, as radioactive decay and ligand decomposition resulted in greatly reduced specific binding observed after 72 hrs. Incubation buffer: 25 mM HEPES-KOH (pH 7.0), 1.5 mM CaCl2, 1 mM MgSO4, 0.1 M NaCl, 1 mM 1,10-phenanthroline, and 1 Complete™ protease inhibitor tablet/100 mL (Roche, catalog number 1873580). Perkin Elmer frozen hMC5 membranes: catalog number RBXMC5M400UA, 0.4 mL/vial; 400 microassays/vial, 0.78 mg/mL protein concentration. Vials of frozen membranes were thawed rapidly immediately before use, diluted with binding buffer and vortexed. Resuspended membranes were kept on ice until they were added to the wells of the plate. Assays were performed in 96 well polypropylene plates. Membranes (0.78 μg 40 μL of a 1:40 dilution in incubation buffer) were added to [125I] NDP-MSH (0.84 nM; 2200 Ci/mmol) and test compounds in a total volume of 140 μL. This was incubated for 1 hr at 37° C. Non-specific binding was determined with 3 mM NDP-MSH. Plates were filtered using a Tomtec cell harvester with GF/A filters (Wallac) (presoaked in 0.6% polyethylenimine) and washed three times with 1.0 mL ice-cold wash buffer (the above incubation buffer without 1,10-phenanthroline and Complete™ protease inhibitor tablet). The filters were dried in a 37° C. oven, placed in a sample bag and 5 mL Betaplatescint (Wallac) was added. Prepared filters were counted in cassettes in a Microbeta Trilux (Wallac) for 1 min.	ChEMBL	598	11	2	4	5.7	O=C(/C=C/c1ccc(Cl)cc1)NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCN2CCCCC2)N1	nan
	CHEMBL3600842	211817	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	168285801	191479	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5193501	191479	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	44347838	96641	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1561	33	16	22	-0.6	CC(=O)C1C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)CSSC1(C)C	10.1021/jm030111j
	CHEMBL263585	96641	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1561	33	16	22	-0.6	CC(=O)C1C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)CSSC1(C)C	10.1021/jm030111j
	71452720	78969	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2C[C@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	CHEMBL2113031	78969	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2C[C@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	1337	3422	None	6	Human	Binding	pIC50	=	6.0	6.0	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F	10.1016/j.bmcl.2005.05.109
	6918851	3422	None	6	Human	Binding	pIC50	=	6.0	6.0	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F	10.1016/j.bmcl.2005.05.109
	CHEMBL364346	3422	None	6	Human	Binding	pIC50	=	6.0	6.0	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F	10.1016/j.bmcl.2005.05.109
	176	398	None	66	Human	Binding	pIC50	=	5.0	5.0	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	398	None	66	Human	Binding	pIC50	=	5.0	5.0	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	398	None	66	Human	Binding	pIC50	=	5.0	5.0	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	398	None	66	Human	Binding	pIC50	=	5.0	5.0	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	398	None	66	Human	Binding	pIC50	=	5.0	5.0	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	122184577	122427	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600838	122427	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC5 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	1212	1660	None	50	Human	Binding	pIC50	=	5.0	5.0	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1660	None	50	Human	Binding	pIC50	=	5.0	5.0	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1660	None	50	Human	Binding	pIC50	=	5.0	5.0	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1660	None	50	Human	Binding	pIC50	=	5.0	5.0	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1660	None	50	Human	Binding	pIC50	=	5.0	5.0	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	44348183	97163	None	0	Human	Binding	pIC50	=	4.0	4.0	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1493	31	14	21	-0.8	CC(=O)[C@@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL268094	97163	None	0	Human	Binding	pIC50	=	4.0	4.0	-	0	Inhibition of human melanocortin 5 receptorInhibition of human melanocortin 5 receptor	ChEMBL	1493	31	14	21	-0.8	CC(=O)[C@@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	44396986	67430	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	CHEMBL188966	67430	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	CHEMBL442504	213914	None	0	Human	Binding	pKi	=	10.1	10.1	-1	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm010165y
	CHEMBL415165	213174	None	0	Human	Binding	pKi	=	9.8	9.8	-1	5	Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0501432
	CHEMBL414718	213149	None	0	Human	Binding	pKi	=	9.6	9.6	-2	4	Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(N)=O	10.1021/jm0501432
	CHEMBL408843	212733	None	0	Human	Binding	pKi	=	9.4	9.4	1	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CC(=O)N[C@@H]1CSSC[C@@H](C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm010165y
	57646411	76919	None	0	Human	Binding	pKi	=	9.3	9.3	-1	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1739	49	24	20	-1.7	CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070245	76919	None	0	Human	Binding	pKi	=	9.3	9.3	-1	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1739	49	24	20	-1.7	CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	1324	302	None	25	Human	Binding	pKi	=	9.3	9.3	-6	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	16154396	302	None	25	Human	Binding	pKi	=	9.3	9.3	-6	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	16197727	302	None	25	Human	Binding	pKi	=	9.3	9.3	-6	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	44285019	302	None	25	Human	Binding	pKi	=	9.3	9.3	-6	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	57514683	302	None	25	Human	Binding	pKi	=	9.3	9.3	-6	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	91898441	302	None	25	Human	Binding	pKi	=	9.3	9.3	-6	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	CHEMBL441738	302	None	25	Human	Binding	pKi	=	9.3	9.3	-6	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	DB04931	302	None	25	Human	Binding	pKi	=	9.3	9.3	-6	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	CHEMBL1923667	209086	None	0	Human	Binding	pKi	=	9.2	9.2	1	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm201226w
	CHEMBL1923665	209085	None	0	Human	Binding	pKi	=	9.1	9.1	-1	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm201226w
	CHEMBL266879	210704	None	0	Human	Binding	pKi	=	9.1	9.1	-3	4	Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0501432
	CHEMBL2370964	209965	None	0	Human	Binding	pKi	=	9	9.0	-1	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	57646437	76920	None	0	Human	Binding	pKi	=	8.9	8.9	-10	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1855	51	23	23	-2.2	CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70684621	76920	None	0	Human	Binding	pKi	=	8.9	8.9	-10	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1855	51	23	23	-2.2	CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929804	76920	None	0	Human	Binding	pKi	=	8.9	8.9	-10	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1855	51	23	23	-2.2	CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070246	76920	None	0	Human	Binding	pKi	=	8.9	8.9	-10	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1855	51	23	23	-2.2	CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	56851058	69071	None	0	Human	Binding	pKi	=	8.9	8.9	1	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	1823	57	25	20	-0.9	C#CCCCC(=O)NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O)C(C)C	10.1021/jm201226w
	57394091	69071	None	0	Human	Binding	pKi	=	8.9	8.9	1	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	1823	57	25	20	-0.9	C#CCCCC(=O)NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O)C(C)C	10.1021/jm201226w
	91930626	69071	None	0	Human	Binding	pKi	=	8.9	8.9	1	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	1823	57	25	20	-0.9	C#CCCCC(=O)NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O)C(C)C	10.1021/jm201226w
	CHEMBL1923666	69071	None	0	Human	Binding	pKi	=	8.9	8.9	1	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	1823	57	25	20	-0.9	C#CCCCC(=O)NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O)C(C)C	10.1021/jm201226w
	57646441	76918	None	0	Human	Binding	pKi	=	8.8	8.8	-13	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1706	46	22	20	-1.4	CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070243	76918	None	0	Human	Binding	pKi	=	8.8	8.8	-13	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1706	46	22	20	-1.4	CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	57817773	76923	None	0	Human	Binding	pKi	=	8	8.0	-58	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@H](CN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70684623	76923	None	0	Human	Binding	pKi	=	8	8.0	-58	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@H](CN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929806	76923	None	0	Human	Binding	pKi	=	8	8.0	-58	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@H](CN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070249	76923	None	0	Human	Binding	pKi	=	8	8.0	-58	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@H](CN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	9915636	66822	None	0	Human	Binding	pKi	=	6	6.0	-48	4	Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	553	12	3	6	3.5	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	CHEMBL186083	66822	None	0	Human	Binding	pKi	=	6	6.0	-48	4	Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	553	12	3	6	3.5	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	44395681	66868	None	0	Human	Binding	pKi	=	6	6.0	-70	4	Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	567	13	3	6	3.8	NCCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	CHEMBL186289	66868	None	0	Human	Binding	pKi	=	6	6.0	-70	4	Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	567	13	3	6	3.8	NCCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	16046215	80087	None	0	Human	Binding	pKi	=	6	6.0	-39	4	Displacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cells	ChEMBL	441	7	1	3	5.2	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](N)CC(C)C)c1	10.1016/j.bmcl.2006.06.075
	CHEMBL213122	80087	None	0	Human	Binding	pKi	=	6	6.0	-39	4	Displacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cells	ChEMBL	441	7	1	3	5.2	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](N)CC(C)C)c1	10.1016/j.bmcl.2006.06.075
	16046215	80087	None	0	Human	Binding	pKi	=	6	6.0	-39	4	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	441	7	1	3	5.2	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](N)CC(C)C)c1	10.1021/jm701137s
	CHEMBL213122	80087	None	0	Human	Binding	pKi	=	6	6.0	-39	4	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	441	7	1	3	5.2	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](N)CC(C)C)c1	10.1021/jm701137s
	9915636	66822	None	0	Human	Binding	pKi	=	6	6.0	-48	4	Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	553	12	3	6	3.5	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	CHEMBL186083	66822	None	0	Human	Binding	pKi	=	6	6.0	-48	4	Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	553	12	3	6	3.5	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	156010247	177070	None	0	Human	Binding	pKi	=	5	5.0	-5	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta countingDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta counting	ChEMBL	2913	40	44	46	-16.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)O)[C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC3=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/acs.jmedchem.0c00485
	CHEMBL4633001	177070	None	0	Human	Binding	pKi	=	5	5.0	-5	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta countingDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta counting	ChEMBL	2913	40	44	46	-16.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)O)[C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC3=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/acs.jmedchem.0c00485
	44434706	89595	None	0	Human	Binding	pKi	=	5	5.0	-7	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	499	9	2	2	7.3	Cc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL237504	89595	None	0	Human	Binding	pKi	=	5	5.0	-7	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	499	9	2	2	7.3	Cc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	44434860	90040	None	0	Human	Binding	pKi	=	5	5.0	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	449	8	2	2	5.9	N[C@H]1CC[C@H](N(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238159	90040	None	0	Human	Binding	pKi	=	5	5.0	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	449	8	2	2	5.9	N[C@H]1CC[C@H](N(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	44434632	146307	None	0	Human	Binding	pKi	=	5	5.0	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	375	10	2	2	4.4	NCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL392096	146307	None	0	Human	Binding	pKi	=	5	5.0	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	375	10	2	2	4.4	NCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434601	146466	None	0	Human	Binding	pKi	=	5	5.0	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	358	8	1	2	4.3	NCCCN(C/C=C/c1ccccc1)C(=O)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	CHEMBL392223	146466	None	0	Human	Binding	pKi	=	5	5.0	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	358	8	1	2	4.3	NCCCN(C/C=C/c1ccccc1)C(=O)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	44434870	148146	None	0	Human	Binding	pKi	=	5	5.0	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	449	8	2	2	5.9	NC1CCCC(N(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	CHEMBL393553	148146	None	0	Human	Binding	pKi	=	5	5.0	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	449	8	2	2	5.9	NC1CCCC(N(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	71454518	79148	None	0	Human	Binding	pKi	=	5	5.0	-6	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	456	10	4	3	3.3	NC(N)=NCCC[C@H](N)C(=O)N(CCc1c[nH]c2ccccc12)Cc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL2113315	79148	None	0	Human	Binding	pKi	=	5	5.0	-6	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	456	10	4	3	3.3	NC(N)=NCCC[C@H](N)C(=O)N(CCc1c[nH]c2ccccc12)Cc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	2817655	205569	None	5	Human	Binding	pKi	=	4	4.0	-	1	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	297	4	1	1	5.3	c1ccc2cc(CNCc3cccc4ccccc34)ccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL8129	205569	None	5	Human	Binding	pKi	=	4	4.0	-	1	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	297	4	1	1	5.3	c1ccc2cc(CNCc3cccc4ccccc34)ccc2c1	10.1016/s0960-894x(02)00088-4
	11191792	67184	None	0	Human	Binding	pKi	=	6.0	6.0	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	529	6	3	3	4.7	CC1C(=O)NCCN1/C(=N/c1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1	10.1021/jm0400496
	CHEMBL187757	67184	None	0	Human	Binding	pKi	=	6.0	6.0	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	529	6	3	3	4.7	CC1C(=O)NCCN1/C(=N/c1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1	10.1021/jm0400496
	9958649	124355	None	0	Human	Binding	pKi	=	8.0	8.0	53	3	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	529	6	3	3	5.6	CC1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC(C)N1	10.1021/jm0400496
	CHEMBL363730	124355	None	0	Human	Binding	pKi	=	8.0	8.0	53	3	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	529	6	3	3	5.6	CC1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC(C)N1	10.1021/jm0400496
	CHEMBL2070373	209184	None	0	Human	Binding	pKi	=	7.0	7.0	-14	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	44577062	193372	None	0	Human	Binding	pKi	=	7.0	7.0	-26	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	518	9	2	4	4.6	CNCC(=O)N[C@H](c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL525177	193372	None	0	Human	Binding	pKi	=	7.0	7.0	-26	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	518	9	2	4	4.6	CNCC(=O)N[C@H](c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	44577090	178664	None	0	Human	Binding	pKi	=	6.0	6.0	-109	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	502	9	2	4	4.0	CNCC(=O)N[C@H](c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL467771	178664	None	0	Human	Binding	pKi	=	6.0	6.0	-109	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	502	9	2	4	4.0	CNCC(=O)N[C@H](c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	44577060	188050	None	0	Human	Binding	pKi	=	6.0	6.0	-316	8	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL497746	188050	None	0	Human	Binding	pKi	=	6.0	6.0	-316	8	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	44434692	88523	None	0	Human	Binding	pKi	=	5.0	5.0	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	651	13	3	5	8.3	COc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL235176	88523	None	0	Human	Binding	pKi	=	5.0	5.0	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	651	13	3	5	8.3	COc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	44434841	88699	None	0	Human	Binding	pKi	=	5.0	5.0	-3	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	455	11	4	2	4.9	N=C(N)NCCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236022	88699	None	0	Human	Binding	pKi	=	5.0	5.0	-3	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	455	11	4	2	4.9	N=C(N)NCCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	10137615	89734	None	0	Human	Binding	pKi	=	5.0	5.0	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	431	9	2	2	5.4	CC(c1ccc(C(F)(F)F)cc1)N(CCCCCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237692	89734	None	0	Human	Binding	pKi	=	5.0	5.0	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	431	9	2	2	5.4	CC(c1ccc(C(F)(F)F)cc1)N(CCCCCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434754	90234	None	0	Human	Binding	pKi	=	5.0	5.0	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	557	11	3	4	7.2	COc1cc(O)ccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238345	90234	None	0	Human	Binding	pKi	=	5.0	5.0	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	557	11	3	4	7.2	COc1cc(O)ccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434862	90246	None	0	Human	Binding	pKi	=	5.0	5.0	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	477	10	2	2	6.4	NCC1CCC(CN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238368	90246	None	0	Human	Binding	pKi	=	5.0	5.0	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	477	10	2	2	6.4	NCC1CCC(CN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	44434600	148600	None	0	Human	Binding	pKi	=	5.0	5.0	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	361	9	2	2	4.0	NCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393918	148600	None	0	Human	Binding	pKi	=	5.0	5.0	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	361	9	2	2	4.0	NCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434763	151341	None	0	Human	Binding	pKi	=	5.0	5.0	-17	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	685	13	3	5	9.0	COc1cc(Cl)c(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL396111	151341	None	0	Human	Binding	pKi	=	5.0	5.0	-17	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	685	13	3	5	9.0	COc1cc(Cl)c(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	6918276	15609	None	7	Human	Binding	pKi	=	6.9	6.9	-12	8	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	CHEMBL1221512	15609	None	7	Human	Binding	pKi	=	6.9	6.9	-12	8	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	168282596	190904	None	0	Human	Binding	pKi	=	6.9	6.9	-1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2990	66	33	37	-3.8	CC(C)C[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)CSSC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/acs.jmedchem.2c00786
	CHEMBL5185132	190904	None	0	Human	Binding	pKi	=	6.9	6.9	-1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2990	66	33	37	-3.8	CC(C)C[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)CSSC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/acs.jmedchem.2c00786
	CHEMBL2370966	209967	None	0	Human	Binding	pKi	=	6.9	6.9	28	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	9960253	116947	None	0	Human	Binding	pKi	=	5.9	5.9	-5	4	Binding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	595	8	3	6	2.8	CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	CHEMBL338594	116947	None	0	Human	Binding	pKi	=	5.9	5.9	-5	4	Binding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	595	8	3	6	2.8	CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	24848995	117945	None	0	Human	Binding	pKi	=	5.9	5.9	-50	3	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	583	8	2	7	3.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cncn2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	CHEMBL340355	117945	None	0	Human	Binding	pKi	=	5.9	5.9	-50	3	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	583	8	2	7	3.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cncn2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	44415417	80144	None	0	Human	Binding	pKi	=	5.9	5.9	-10	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	465	7	1	3	5.5	CC(C)C[C@H](N)c1cccc(F)c1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	CHEMBL213380	80144	None	0	Human	Binding	pKi	=	5.9	5.9	-10	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	465	7	1	3	5.5	CC(C)C[C@H](N)c1cccc(F)c1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	23635235	166499	None	0	Human	Binding	pKi	=	5.9	5.9	-223	5	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
	CHEMBL427860	166499	None	0	Human	Binding	pKi	=	5.9	5.9	-223	5	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
	10232787	140379	None	0	Human	Binding	pKi	=	5.9	5.9	-165	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	619	12	2	5	5.0	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2NCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL380855	140379	None	0	Human	Binding	pKi	=	5.9	5.9	-165	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	619	12	2	5	5.0	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2NCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	24740419	148192	None	0	Human	Binding	pKi	=	5.9	5.9	-478	4	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	575	11	1	5	5.4	Cc1ccc([C@@H](CC(C)C)NC(=O)CCN(C)C)c(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3Cl)CC2)n1	10.1021/jm701137s
	CHEMBL393584	148192	None	0	Human	Binding	pKi	=	5.9	5.9	-478	4	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	575	11	1	5	5.4	Cc1ccc([C@@H](CC(C)C)NC(=O)CCN(C)C)c(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3Cl)CC2)n1	10.1021/jm701137s
	44397281	126542	None	0	Human	Binding	pKi	=	5.9	5.9	-109	3	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	587	12	3	5	4.0	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCCc3ccccc3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	CHEMBL365237	126542	None	0	Human	Binding	pKi	=	5.9	5.9	-109	3	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	587	12	3	5	4.0	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCCc3ccccc3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	44434694	88599	None	0	Human	Binding	pKi	=	4.9	4.9	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	665	14	3	5	8.7	CCOc1cc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)ccc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL235589	88599	None	0	Human	Binding	pKi	=	4.9	4.9	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	665	14	3	5	8.7	CCOc1cc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)ccc1OC	10.1016/j.bmc.2007.06.003
	44434611	88612	None	0	Human	Binding	pKi	=	4.9	4.9	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	373	6	2	2	3.9	NCCCN(C(=O)/C=C/c1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	CHEMBL235627	88612	None	0	Human	Binding	pKi	=	4.9	4.9	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	373	6	2	2	3.9	NCCCN(C(=O)/C=C/c1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	44435220	89250	None	0	Human	Binding	pKi	=	4.9	4.9	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	609	10	2	3	8.9	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)c3cc4cc(OCc5ccccc5)ccc4[nH]3)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236803	89250	None	0	Human	Binding	pKi	=	4.9	4.9	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	609	10	2	3	8.9	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)c3cc4cc(OCc5ccccc5)ccc4[nH]3)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434701	89499	None	0	Human	Binding	pKi	=	4.9	4.9	-9	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	499	9	2	2	7.3	Cc1cccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)c1	10.1016/j.bmc.2007.06.003
	CHEMBL237291	89499	None	0	Human	Binding	pKi	=	4.9	4.9	-9	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	499	9	2	2	7.3	Cc1cccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)c1	10.1016/j.bmc.2007.06.003
	10177247	89512	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	371	7	2	2	4.2	NCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237314	89512	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	371	7	2	2	4.2	NCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434599	89917	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	333	7	2	2	3.7	NCCCN(C/C=C/c1ccccc1)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237957	89917	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	333	7	2	2	3.7	NCCCN(C/C=C/c1ccccc1)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434581	167049	None	0	Human	Binding	pKi	=	4.9	4.9	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	395	7	2	2	5.2	NCCN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL428903	167049	None	0	Human	Binding	pKi	=	4.9	4.9	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	395	7	2	2	5.2	NCCN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	71461662	79114	None	0	Human	Binding	pKi	=	4.9	4.9	-1	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	442	9	4	3	3.2	NC(N)=NCCC[C@H](N)C(=O)N(Cc1cccc2ccccc12)Cc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL2113280	79114	None	0	Human	Binding	pKi	=	4.9	4.9	-1	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	442	9	4	3	3.2	NC(N)=NCCC[C@H](N)C(=O)N(Cc1cccc2ccccc12)Cc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL2070374	209185	None	0	Human	Binding	pKi	=	7.9	7.9	-22	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CNC(=O)CN(CC(=O)O)CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	44577092	178643	None	0	Human	Binding	pKi	=	7.9	7.9	-11	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	548	10	2	5	4.6	CNCC(=O)N[C@H](c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2OC)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL467586	178643	None	0	Human	Binding	pKi	=	7.9	7.9	-11	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	548	10	2	5	4.6	CNCC(=O)N[C@H](c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2OC)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	44347119	114421	None	0	Human	Binding	pKi	=	6.9	6.9	-346	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	752	9	10	7	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL333178	114421	None	0	Human	Binding	pKi	=	6.9	6.9	-346	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	752	9	10	7	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44433294	153041	None	0	Human	Binding	pKi	=	5.9	5.9	-676	3	Binding affinity at human MC5RBinding affinity at human MC5R	ChEMBL	619	11	2	5	4.6	CC(C)C[C@H](NC(=O)CCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL397580	153041	None	0	Human	Binding	pKi	=	5.9	5.9	-676	3	Binding affinity at human MC5RBinding affinity at human MC5R	ChEMBL	619	11	2	5	4.6	CC(C)C[C@H](NC(=O)CCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	23653113	88650	None	0	Human	Binding	pKi	=	4.9	4.9	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	427	9	4	2	4.2	N=C(N)NCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235798	88650	None	0	Human	Binding	pKi	=	4.9	4.9	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	427	9	4	2	4.2	N=C(N)NCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434616	88693	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	377	10	2	2	4.8	CCC(c1ccccc1)N(CCCCN)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236003	88693	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	377	10	2	2	4.8	CCC(c1ccccc1)N(CCCCN)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434570	89777	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	347	8	2	2	3.6	NCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237719	89777	None	0	Human	Binding	pKi	=	4.9	4.9	1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	347	8	2	2	3.6	NCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434598	89814	None	0	Human	Binding	pKi	=	4.9	4.9	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	349	9	2	2	3.5	NCCCN(CCCc1ccccc1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237743	89814	None	0	Human	Binding	pKi	=	4.9	4.9	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	349	9	2	2	3.5	NCCCN(CCCc1ccccc1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	168289584	191784	None	0	Human	Binding	pKi	=	6.9	6.9	-10	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	3108	98	37	41	-6.4	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CSC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CSC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5198158	191784	None	0	Human	Binding	pKi	=	6.9	6.9	-10	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	3108	98	37	41	-6.4	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CSC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CSC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL2370968	209969	None	0	Human	Binding	pKi	=	7.9	7.9	-70	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	44347331	16325	None	0	Human	Binding	pKi	=	6.9	6.9	-257	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	CHEMBL122773	16325	None	0	Human	Binding	pKi	=	6.9	6.9	-257	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	44323234	168054	None	0	Human	Binding	pKi	=	6.9	6.9	-11	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL432377	168054	None	0	Human	Binding	pKi	=	6.9	6.9	-11	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	11226756	119972	None	0	Human	Binding	pKi	=	5.9	5.9	-23	3	Binding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	559	8	2	5	3.5	CN(C)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	CHEMBL349850	119972	None	0	Human	Binding	pKi	=	5.9	5.9	-23	3	Binding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	559	8	2	5	3.5	CN(C)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	10211466	168898	None	0	Human	Binding	pKi	=	5.9	5.9	-19	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	633	12	2	5	5.1	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2(C)NCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL438432	168898	None	0	Human	Binding	pKi	=	5.9	5.9	-19	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	633	12	2	5	5.1	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2(C)NCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	44397283	67164	None	0	Human	Binding	pKi	=	5.9	5.9	-112	3	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	591	11	3	5	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCc3ccccc3F)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	CHEMBL187659	67164	None	0	Human	Binding	pKi	=	5.9	5.9	-112	3	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	591	11	3	5	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCc3ccccc3F)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	44393418	155698	None	0	Human	Binding	pKi	=	4.9	4.9	-14	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	589	8	2	7	3.2	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(Cn3cncn3)CCCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL405150	155698	None	0	Human	Binding	pKi	=	4.9	4.9	-14	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	589	8	2	7	3.2	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(Cn3cncn3)CCCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	2852098	205462	None	13	Human	Binding	pKi	=	4.9	4.9	1	3	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	300	5	2	1	4.7	c1ccc2cc(CNCCc3c[nH]c4ccccc34)ccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL8045	205462	None	13	Human	Binding	pKi	=	4.9	4.9	1	3	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	300	5	2	1	4.7	c1ccc2cc(CNCCc3c[nH]c4ccccc34)ccc2c1	10.1016/s0960-894x(02)00088-4
	11272524	66861	None	0	Human	Binding	pKi	=	6.8	6.8	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	528	6	2	2	6.9	CC1CC(C)CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)C1	10.1021/jm0400496
	CHEMBL186249	66861	None	0	Human	Binding	pKi	=	6.8	6.8	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	528	6	2	2	6.9	CC1CC(C)CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)C1	10.1021/jm0400496
	57817730	76921	None	0	Human	Binding	pKi	=	7.8	7.8	-75	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1919	56	24	26	-3.5	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70684622	76921	None	0	Human	Binding	pKi	=	7.8	7.8	-75	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1919	56	24	26	-3.5	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929805	76921	None	0	Human	Binding	pKi	=	7.8	7.8	-75	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1919	56	24	26	-3.5	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070247	76921	None	0	Human	Binding	pKi	=	7.8	7.8	-75	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1919	56	24	26	-3.5	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL438235	213757	None	0	Human	Binding	pKi	=	6.8	6.8	-1	2	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)CSSC1(C)C	10.1021/jm030119t
	44347221	16633	None	0	Human	Binding	pKi	=	6.8	6.8	-173	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL124169	16633	None	0	Human	Binding	pKi	=	6.8	6.8	-173	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	16132144	209277	None	36	Human	Binding	pKi	=	6.8	6.8	-100	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm201489a
	16133793	209277	None	36	Human	Binding	pKi	=	6.8	6.8	-100	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm201489a
	44273719	209277	None	36	Human	Binding	pKi	=	6.8	6.8	-100	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm201489a
	CHEMBL214332	209277	None	36	Human	Binding	pKi	=	6.8	6.8	-100	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm201489a
	44265672	10179	None	0	Human	Binding	pKi	=	4.8	4.8	-6	4	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	442	10	5	3	3.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)NCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00089-6
	CHEMBL1159699	10179	None	0	Human	Binding	pKi	=	4.8	4.8	-6	4	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	442	10	5	3	3.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)NCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00089-6
	44265707	10182	None	0	Human	Binding	pKi	=	4.8	4.8	-2	4	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	354	10	3	4	2.1	C=CCOC(=O)[C@H](CCCN=C(N)N)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	CHEMBL1159701	10182	None	0	Human	Binding	pKi	=	4.8	4.8	-2	4	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	354	10	3	4	2.1	C=CCOC(=O)[C@H](CCCN=C(N)N)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	44434790	90237	None	0	Human	Binding	pKi	=	4.8	4.8	1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	399	7	4	2	3.4	N=C(N)NCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL238353	90237	None	0	Human	Binding	pKi	=	4.8	4.8	1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	399	7	4	2	3.4	N=C(N)NCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434703	146106	None	0	Human	Binding	pKi	=	4.8	4.8	-12	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	499	9	2	2	7.3	Cc1ccccc1CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL391944	146106	None	0	Human	Binding	pKi	=	4.8	4.8	-12	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	499	9	2	2	7.3	Cc1ccccc1CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434765	161769	None	0	Human	Binding	pKi	=	4.8	4.8	-13	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	643	11	3	3	9.1	NC1CCC(CC2CCC(N(Cc3c(F)cccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL413982	161769	None	0	Human	Binding	pKi	=	4.8	4.8	-13	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	643	11	3	3	9.1	NC1CCC(CC2CCC(N(Cc3c(F)cccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	51346771	58224	None	0	Human	Binding	pKi	=	5.8	5.8	-4	4	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in BHK cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in BHK cells	ChEMBL	671	10	2	9	3.3	COCC(=O)N[C@H]1Cc2cc3c(c(c2)Cc2ccc(cc2)Oc2cccc(c2)CN(CCCN2CCN(CCCN)CC2)C1=O)OCOC3	10.1016/j.bmcl.2011.01.011
	CHEMBL1682208	58224	None	0	Human	Binding	pKi	=	5.8	5.8	-4	4	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in BHK cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in BHK cells	ChEMBL	671	10	2	9	3.3	COCC(=O)N[C@H]1Cc2cc3c(c(c2)Cc2ccc(cc2)Oc2cccc(c2)CN(CCCN2CCN(CCCN)CC2)C1=O)OCOC3	10.1016/j.bmcl.2011.01.011
	CHEMBL2370553	209868	None	0	Human	Binding	pKi	=	7.8	7.8	-10	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CC(=O)N[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm010165y
	44400935	70860	None	0	Human	Binding	pKi	=	6.8	6.8	-104	4	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	613	10	2	5	5.5	O=C(N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)N1CCCC1	10.1016/j.bmcl.2005.03.053
	CHEMBL195110	70860	None	0	Human	Binding	pKi	=	6.8	6.8	-104	4	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	613	10	2	5	5.5	O=C(N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)N1CCCC1	10.1016/j.bmcl.2005.03.053
	44432966	146299	None	0	Human	Binding	pKi	=	5.8	5.8	-1659	4	Displacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cells	ChEMBL	560	14	0	6	6.7	COc1ccc(C(=O)c2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	CHEMBL392092	146299	None	0	Human	Binding	pKi	=	5.8	5.8	-1659	4	Displacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cells	ChEMBL	560	14	0	6	6.7	COc1ccc(C(=O)c2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	44393417	96589	None	0	Human	Binding	pKi	=	4.8	4.8	-40	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	589	8	2	7	3.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2CCCCC2Cn2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL263182	96589	None	0	Human	Binding	pKi	=	4.8	4.8	-40	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	589	8	2	7	3.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2CCCCC2Cn2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44434865	88748	None	0	Human	Binding	pKi	=	4.8	4.8	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	589	10	4	3	6.5	NC1CCCC(NC(=O)NC2CCCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	CHEMBL236226	88748	None	0	Human	Binding	pKi	=	4.8	4.8	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	589	10	4	3	6.5	NC1CCCC(NC(=O)NC2CCCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	10200110	89731	None	0	Human	Binding	pKi	=	4.8	4.8	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	385	8	2	2	4.6	NCCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237687	89731	None	0	Human	Binding	pKi	=	4.8	4.8	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	385	8	2	2	4.6	NCCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434828	148120	None	0	Human	Binding	pKi	=	4.8	4.8	1	2	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	427	9	4	2	4.2	N=C(N)NCCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393532	148120	None	0	Human	Binding	pKi	=	4.8	4.8	1	2	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	427	9	4	2	4.2	N=C(N)NCCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434702	149511	None	0	Human	Binding	pKi	=	4.8	4.8	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	605	11	3	3	8.6	Cc1cccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)c1	10.1016/j.bmc.2007.06.003
	CHEMBL394646	149511	None	0	Human	Binding	pKi	=	4.8	4.8	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	605	11	3	3	8.6	Cc1cccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)c1	10.1016/j.bmc.2007.06.003
	138106885	166909	None	75	Human	Binding	pKi	=	4.8	4.8	-3	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
	36314	166909	None	75	Human	Binding	pKi	=	4.8	4.8	-3	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
	CHEMBL428647	166909	None	75	Human	Binding	pKi	=	4.8	4.8	-3	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
	CHEMBL2370963	209964	None	0	Human	Binding	pKi	=	7.8	7.8	-11	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	10408	719	None	28	Human	Binding	pKi	=	7.8	7.8	-3	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/jm201489a
	5329	719	None	28	Human	Binding	pKi	=	7.8	7.8	-3	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/jm201489a
	9941379	719	None	28	Human	Binding	pKi	=	7.8	7.8	-3	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/jm201489a
	CHEMBL2070241	719	None	28	Human	Binding	pKi	=	7.8	7.8	-3	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/jm201489a
	DB11653	719	None	28	Human	Binding	pKi	=	7.8	7.8	-3	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/jm201489a
	16007285	81120	None	0	Human	Binding	pKi	=	6.8	6.8	-13	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	586	10	2	4	5.8	CCC(C)[C@H](NC(=O)CCN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	CHEMBL215659	81120	None	0	Human	Binding	pKi	=	6.8	6.8	-13	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	586	10	2	4	5.8	CCC(C)[C@H](NC(=O)CCN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	CHEMBL409049	212743	None	0	Human	Binding	pKi	=	5.8	5.8	-141	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)CSSC1(C)C	10.1021/jm030119t
	44434855	90028	None	0	Human	Binding	pKi	=	5.8	5.8	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238154	90028	None	0	Human	Binding	pKi	=	5.8	5.8	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44393441	66427	None	0	Human	Binding	pKi	=	4.8	4.8	-1	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	502	6	2	4	3.4	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL185195	66427	None	0	Human	Binding	pKi	=	4.8	4.8	-1	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	502	6	2	4	3.4	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44392514	123865	None	0	Human	Binding	pKi	=	4.8	4.8	-19	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	575	7	2	7	3.0	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN([C@H]2CCCC[C@@H]2n2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL362670	123865	None	0	Human	Binding	pKi	=	4.8	4.8	-19	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	575	7	2	7	3.0	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN([C@H]2CCCC[C@@H]2n2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44434794	88518	None	0	Human	Binding	pKi	=	4.8	4.8	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	413	8	4	2	3.8	N=C(N)NCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235147	88518	None	0	Human	Binding	pKi	=	4.8	4.8	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	413	8	4	2	3.8	N=C(N)NCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434850	89172	None	0	Human	Binding	pKi	=	4.8	4.8	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	461	9	2	2	6.3	NCc1ccc(CN(Cc2ccc3ccccc3c2)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL236645	89172	None	0	Human	Binding	pKi	=	4.8	4.8	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	461	9	2	2	6.3	NCc1ccc(CN(Cc2ccc3ccccc3c2)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	44434656	90021	None	0	Human	Binding	pKi	=	4.8	4.8	-6	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	401	10	2	2	5.2	C/C(=C/c1ccccc1)CN(CCCCCN)C(=O)/C=C/c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL238136	90021	None	0	Human	Binding	pKi	=	4.8	4.8	-6	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	401	10	2	2	5.2	C/C(=C/c1ccccc1)CN(CCCCCN)C(=O)/C=C/c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	11284919	66188	None	0	Human	Binding	pKi	=	5.8	5.8	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	605	7	2	3	7.3	Cc1ccc(C)c(N2CCN(/C(=N/c3ccc(C(=O)NCCc4ccc(Cl)cc4Cl)cc3)NC3CCCCC3)CC2)c1	10.1021/jm0400496
	CHEMBL184385	66188	None	0	Human	Binding	pKi	=	5.8	5.8	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	605	7	2	3	7.3	Cc1ccc(C)c(N2CCN(/C(=N/c3ccc(C(=O)NCCc4ccc(Cl)cc4Cl)cc3)NC3CCCCC3)CC2)c1	10.1021/jm0400496
	CHEMBL420167	213240	None	0	Human	Binding	pKi	=	7.8	7.8	-11	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		NC(=O)[C@H]1CCCCNC(=O)C[C@H](N)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	11341045	66164	None	0	Human	Binding	pKi	=	7.8	7.8	22	4	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	501	6	3	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCNCC2)cc1	10.1021/jm0400496
	CHEMBL184275	66164	None	0	Human	Binding	pKi	=	7.8	7.8	22	4	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	501	6	3	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCNCC2)cc1	10.1021/jm0400496
	23635107	91556	None	0	Human	Binding	pKi	=	6.8	6.8	-63	3	Displacement of [125I]NDP-MSH from human MC5RDisplacement of [125I]NDP-MSH from human MC5R	ChEMBL	516	9	2	4	4.3	CNCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2F)CC1)C(C)C	10.1021/jm070806a
	CHEMBL240571	91556	None	0	Human	Binding	pKi	=	6.8	6.8	-63	3	Displacement of [125I]NDP-MSH from human MC5RDisplacement of [125I]NDP-MSH from human MC5R	ChEMBL	516	9	2	4	4.3	CNCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2F)CC1)C(C)C	10.1021/jm070806a
	23635107	91556	None	0	Human	Binding	pKi	=	6.8	6.8	-63	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	516	9	2	4	4.3	CNCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2F)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL240571	91556	None	0	Human	Binding	pKi	=	6.8	6.8	-63	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	516	9	2	4	4.3	CNCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2F)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	44562440	179039	None	0	Human	Binding	pKi	=	5.8	5.8	-27	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	534	10	3	5	3.7	CNCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2C(O)CC(C)C)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL471340	179039	None	0	Human	Binding	pKi	=	5.8	5.8	-27	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	534	10	3	5	3.7	CNCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2C(O)CC(C)C)CC1	10.1016/j.bmcl.2008.07.076
	44392535	64270	None	0	Human	Binding	pKi	=	4.8	4.8	-33	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	575	8	2	7	2.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(Cn3cncn3)CCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL180937	64270	None	0	Human	Binding	pKi	=	4.8	4.8	-33	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	575	8	2	7	2.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(Cn3cncn3)CCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44434872	88562	None	0	Human	Binding	pKi	=	4.8	4.8	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	389	7	2	2	4.8	NC1CCCC(N(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	CHEMBL235382	88562	None	0	Human	Binding	pKi	=	4.8	4.8	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	389	7	2	2	4.8	NC1CCCC(N(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	44434758	88692	None	0	Human	Binding	pKi	=	4.8	4.8	-19	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	755	14	3	5	9.6	COc1cc(Br)c(/C=C/CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL236002	88692	None	0	Human	Binding	pKi	=	4.8	4.8	-19	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	755	14	3	5	9.6	COc1cc(Br)c(/C=C/CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	9924916	89007	None	0	Human	Binding	pKi	=	4.8	4.8	2	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	357	6	2	2	3.9	NCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236447	89007	None	0	Human	Binding	pKi	=	4.8	4.8	2	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	357	6	2	2	3.9	NCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434781	89902	None	0	Human	Binding	pKi	=	4.8	4.8	-23	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	485	9	2	2	7.0	NC1CCC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237919	89902	None	0	Human	Binding	pKi	=	4.8	4.8	-23	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	485	9	2	2	7.0	NC1CCC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	9969456	147615	None	0	Human	Binding	pKi	=	4.8	4.8	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	371	7	2	2	4.7	NCCCCN(Cc1ccc2ccccc2c1)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393125	147615	None	0	Human	Binding	pKi	=	4.8	4.8	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	371	7	2	2	4.7	NCCCCN(Cc1ccc2ccccc2c1)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434863	148142	None	0	Human	Binding	pKi	=	4.8	4.8	-7	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	417	9	2	2	5.3	NCC1CCC(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL393552	148142	None	0	Human	Binding	pKi	=	4.8	4.8	-7	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	417	9	2	2	5.3	NCC1CCC(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	2163781	97375	None	9	Human	Binding	pKi	=	4.8	4.8	1	3	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	289	5	3	1	4.0	c1ccc2c(CCNCc3c[nH]c4ccccc34)c[nH]c2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL269653	97375	None	9	Human	Binding	pKi	=	4.8	4.8	1	3	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	289	5	3	1	4.0	c1ccc2c(CCNCc3c[nH]c4ccccc34)c[nH]c2c1	10.1016/s0960-894x(02)00088-4
	168281969	191276	None	0	Human	Binding	pKi	=	6.7	6.7	-13	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	3072	100	37	39	-7.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5190661	191276	None	0	Human	Binding	pKi	=	6.7	6.7	-13	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	3072	100	37	39	-7.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL1201469	14505	None	0	Human	Binding	pKi	=	5.7	5.7	-1	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL		None	None	None		None	nan
	CHEMBL438030	213742	None	0	Human	Binding	pKi	=	6.7	6.7	-4	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	44397304	126824	None	0	Human	Binding	pKi	=	5.7	5.7	-158	4	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	579	11	3	6	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCc3cccs3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	CHEMBL365465	126824	None	0	Human	Binding	pKi	=	5.7	5.7	-158	4	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	579	11	3	6	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCc3cccs3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	10270570	89031	None	0	Human	Binding	pKi	=	4.7	4.7	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	371	6	2	2	4.4	CC(c1ccc2ccccc2c1)N(CCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236450	89031	None	0	Human	Binding	pKi	=	4.7	4.7	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	371	6	2	2	4.4	CC(c1ccc2ccccc2c1)N(CCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434639	148155	None	0	Human	Binding	pKi	=	4.7	4.7	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	405	13	2	2	5.1	NCCCCCN(CCCc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393557	148155	None	0	Human	Binding	pKi	=	4.7	4.7	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	405	13	2	2	5.1	NCCCCCN(CCCc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	168273045	190252	None	0	Human	Binding	pKi	=	6.7	6.7	-1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2905	62	33	37	-5.8	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5175392	190252	None	0	Human	Binding	pKi	=	6.7	6.7	-1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2905	62	33	37	-5.8	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	168281969	191276	None	0	Human	Binding	pKi	=	6.7	6.7	-13	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	3072	100	37	39	-7.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5190661	191276	None	0	Human	Binding	pKi	=	6.7	6.7	-13	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	3072	100	37	39	-7.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	11375764	66687	None	0	Human	Binding	pKi	=	8.7	8.7	398	3	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	6	3	3	5.2	C[C@@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	CHEMBL185469	66687	None	0	Human	Binding	pKi	=	8.7	8.7	398	3	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	6	3	3	5.2	C[C@@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	59149264	76800	None	0	Human	Binding	pKi	=	8.5	8.5	-22	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1946	57	23	26	-3.0	CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70684624	76800	None	0	Human	Binding	pKi	=	8.5	8.5	-22	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1946	57	23	26	-3.0	CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929810	76800	None	0	Human	Binding	pKi	=	8.5	8.5	-22	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1946	57	23	26	-3.0	CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2069317	76800	None	0	Human	Binding	pKi	=	8.5	8.5	-22	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1946	57	23	26	-3.0	CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL331259	211359	None	0	Human	Binding	pKi	=	7.7	7.7	-70	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm010165y
	44410802	140383	None	0	Human	Binding	pKi	=	5.7	5.7	-114	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	633	12	1	5	5.3	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2c3ccccc3CN2C)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL380858	140383	None	0	Human	Binding	pKi	=	5.7	5.7	-114	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	633	12	1	5	5.3	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2c3ccccc3CN2C)CC1	10.1016/j.bmcl.2005.10.103
	44434661	88511	None	0	Human	Binding	pKi	=	4.7	4.7	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	415	11	2	3	4.4	NCCCCCN(Cc1ccccc1)C(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL235136	88511	None	0	Human	Binding	pKi	=	4.7	4.7	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	415	11	2	3	4.4	NCCCCCN(Cc1ccccc1)C(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmc.2007.06.003
	44434683	89301	None	0	Human	Binding	pKi	=	4.7	4.7	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	405	10	3	3	4.9	C/C(=C\c1ccccc1)CN(CCCCCCN)C(=O)c1cc2cc(O)ccc2[nH]1	10.1016/j.bmc.2007.06.003
	CHEMBL236847	89301	None	0	Human	Binding	pKi	=	4.7	4.7	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	405	10	3	3	4.9	C/C(=C\c1ccccc1)CN(CCCCCCN)C(=O)c1cc2cc(O)ccc2[nH]1	10.1016/j.bmc.2007.06.003
	9946358	151956	None	0	Human	Binding	pKi	=	4.7	4.7	1	2	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	349	9	2	2	3.5	NCCN(CCCc1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL396655	151956	None	0	Human	Binding	pKi	=	4.7	4.7	1	2	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	349	9	2	2	3.5	NCCN(CCCc1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434635	168885	None	0	Human	Binding	pKi	=	4.7	4.7	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	363	10	2	2	4.3	NCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL438334	168885	None	0	Human	Binding	pKi	=	4.7	4.7	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	363	10	2	2	4.3	NCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	11364326	66684	None	0	Human	Binding	pKi	=	7.7	7.7	27	3	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	6	3	3	5.2	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	CHEMBL185455	66684	None	0	Human	Binding	pKi	=	7.7	7.7	27	3	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	6	3	3	5.2	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	CHEMBL410168	212802	None	0	Human	Binding	pKi	=	6.7	6.7	-9	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	CHEMBL427629	213355	None	0	Human	Binding	pKi	=	6.7	6.7	5	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	1334	1500	None	7	Human	Binding	pKi	=	5.7	5.7	-3	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		None	10.1021/jm030119t
	16133814	1500	None	7	Human	Binding	pKi	=	5.7	5.7	-3	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		None	10.1021/jm030119t
	CHEMBL437050	1500	None	7	Human	Binding	pKi	=	5.7	5.7	-3	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		None	10.1021/jm030119t
	16038315	138756	None	0	Human	Binding	pKi	=	5.7	5.7	-309	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	612	13	3	7	3.5	COc1ccccc1CCNCc1cccnc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2006.04.069
	CHEMBL378046	138756	None	0	Human	Binding	pKi	=	5.7	5.7	-309	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	612	13	3	7	3.5	COc1ccccc1CCNCc1cccnc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2006.04.069
	44434685	89169	None	0	Human	Binding	pKi	=	5.7	5.7	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	497	14	3	3	6.3	NCCCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236638	89169	None	0	Human	Binding	pKi	=	5.7	5.7	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	497	14	3	3	6.3	NCCCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434839	88651	None	0	Human	Binding	pKi	=	4.7	4.7	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	441	10	4	2	4.5	N=C(N)NCCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235802	88651	None	0	Human	Binding	pKi	=	4.7	4.7	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	441	10	4	2	4.5	N=C(N)NCCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434767	89733	None	0	Human	Binding	pKi	=	4.7	4.7	-14	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	616	11	3	4	8.2	N#Cc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL237689	89733	None	0	Human	Binding	pKi	=	4.7	4.7	-14	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	616	11	3	4	8.2	N#Cc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	44434682	148602	None	0	Human	Binding	pKi	=	4.7	4.7	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	451	13	2	2	6.1	NCCCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393919	148602	None	0	Human	Binding	pKi	=	4.7	4.7	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	451	13	2	2	6.1	NCCCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434771	148788	None	0	Human	Binding	pKi	=	4.7	4.7	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	627	11	3	3	8.6	NC1CCC(CC2CCC(N(Cc3c(F)cccc3F)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL394073	148788	None	0	Human	Binding	pKi	=	4.7	4.7	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	627	11	3	3	8.6	NC1CCC(CC2CCC(N(Cc3c(F)cccc3F)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	4189	206920	None	96	Human	Binding	pKi	=	4.7	4.7	-61	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206920	None	96	Human	Binding	pKi	=	4.7	4.7	-61	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206920	None	96	Human	Binding	pKi	=	4.7	4.7	-61	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	2247	505	None	81	Human	Binding	pKi	=	5.7	5.7	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	505	None	81	Human	Binding	pKi	=	5.7	5.7	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	505	None	81	Human	Binding	pKi	=	5.7	5.7	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	505	None	81	Human	Binding	pKi	=	5.7	5.7	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	505	None	81	Human	Binding	pKi	=	5.7	5.7	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL2370533	209866	None	0	Human	Binding	pKi	=	7.7	7.7	-10	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CC(=O)N[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm010165y
	CHEMBL263878	210596	None	0	Human	Binding	pKi	=	6.7	6.7	1	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	156015336	177517	None	0	Human	Binding	pKi	=	5.7	5.7	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta countingDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta counting	ChEMBL	3793	77	53	60	-15.9	CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CCC(N)=O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N3)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2	10.1021/acs.jmedchem.0c00485
	CHEMBL4639782	177517	None	0	Human	Binding	pKi	=	5.7	5.7	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta countingDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta counting	ChEMBL	3793	77	53	60	-15.9	CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CCC(N)=O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N3)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2	10.1021/acs.jmedchem.0c00485
	44434652	89899	None	0	Human	Binding	pKi	=	5.7	5.7	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	403	12	2	2	5.2	NCCCCCN(C/C=C\c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237912	89899	None	0	Human	Binding	pKi	=	5.7	5.7	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	403	12	2	2	5.2	NCCCCCN(C/C=C\c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434707	149545	None	0	Human	Binding	pKi	=	5.7	5.7	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	605	11	3	3	8.6	Cc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL394667	149545	None	0	Human	Binding	pKi	=	5.7	5.7	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	605	11	3	3	8.6	Cc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	10077773	87265	None	4	Human	Binding	pKi	=	5.7	5.7	-1122	4	Displacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cells	ChEMBL	559	14	1	6	7.4	CC(=O)c1ccc(Nc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	CHEMBL233135	87265	None	4	Human	Binding	pKi	=	5.7	5.7	-1122	4	Displacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cells	ChEMBL	559	14	1	6	7.4	CC(=O)c1ccc(Nc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	44434769	89737	None	0	Human	Binding	pKi	=	4.7	4.7	-13	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	659	11	3	3	9.6	NC1CCC(CC2CCC(N(Cc3c(Cl)cccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237698	89737	None	0	Human	Binding	pKi	=	4.7	4.7	-13	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	659	11	3	3	9.6	NC1CCC(CC2CCC(N(Cc3c(Cl)cccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434857	154425	None	0	Human	Binding	pKi	=	4.7	4.7	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	475	13	2	4	3.9	NCCCN1CCN(CCCN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL398980	154425	None	0	Human	Binding	pKi	=	4.7	4.7	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	475	13	2	4	3.9	NCCCN1CCN(CCCN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	168286369	191710	None	0	Human	Binding	pKi	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2962	64	33	37	-4.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5197030	191710	None	0	Human	Binding	pKi	=	6.7	6.7	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2962	64	33	37	-4.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	168283984	191244	None	0	Human	Binding	pKi	=	6.6	6.6	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2937	64	35	39	-7.9	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5190172	191244	None	0	Human	Binding	pKi	=	6.6	6.6	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2937	64	35	39	-7.9	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	11785639	127461	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	6	3	3	5.3	NC1CCN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC1	10.1021/jm0400496
	CHEMBL366036	127461	None	0	Human	Binding	pKi	=	6.6	6.6	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	6	3	3	5.3	NC1CCN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC1	10.1021/jm0400496
	44400812	71298	None	0	Human	Binding	pKi	=	5.6	5.6	-457	2	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	667	12	3	5	6.3	O=C(NCc1ccccc1F)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL195734	71298	None	0	Human	Binding	pKi	=	5.6	5.6	-457	2	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	667	12	3	5	6.3	O=C(NCc1ccccc1F)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	11156852	65683	None	0	Human	Binding	pKi	=	5.6	5.6	-85	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	531	7	3	5	2.9	NCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	CHEMBL183434	65683	None	0	Human	Binding	pKi	=	5.6	5.6	-85	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	531	7	3	5	2.9	NCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	11156852	65683	None	0	Human	Binding	pKi	=	5.6	5.6	-85	4	Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	531	7	3	5	2.9	NCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm049278i
	CHEMBL183434	65683	None	0	Human	Binding	pKi	=	5.6	5.6	-85	4	Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	531	7	3	5	2.9	NCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm049278i
	44434592	89513	None	0	Human	Binding	pKi	=	4.6	4.6	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	399	9	2	2	5.0	NCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237315	89513	None	0	Human	Binding	pKi	=	4.6	4.6	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	399	9	2	2	5.0	NCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434753	89732	None	0	Human	Binding	pKi	=	4.6	4.6	-9	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	699	12	3	4	9.1	COc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1Br	10.1016/j.bmc.2007.06.003
	CHEMBL237688	89732	None	0	Human	Binding	pKi	=	4.6	4.6	-9	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	699	12	3	4	9.1	COc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1Br	10.1016/j.bmc.2007.06.003
	10159196	89736	None	0	Human	Binding	pKi	=	4.6	4.6	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	421	11	2	4	4.4	NCCCCCN(Cc1ccc2c(c1)OCO2)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237694	89736	None	0	Human	Binding	pKi	=	4.6	4.6	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	421	11	2	4	4.4	NCCCCCN(Cc1ccc2c(c1)OCO2)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	10269187	90114	None	0	Human	Binding	pKi	=	4.6	4.6	-4	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	347	5	2	2	3.5	NCCCN(C(=O)c1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	CHEMBL238180	90114	None	0	Human	Binding	pKi	=	4.6	4.6	-4	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	347	5	2	2	3.5	NCCCN(C(=O)c1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	44434868	149549	None	0	Human	Binding	pKi	=	4.6	4.6	-7	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	635	11	5	4	6.7	NC1CCCC(NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	CHEMBL394669	149549	None	0	Human	Binding	pKi	=	4.6	4.6	-7	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	635	11	5	4	6.7	NC1CCCC(NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	CHEMBL407809	212683	None	0	Human	Binding	pKi	=	6.6	6.6	-851	4	Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	CHEMBL433645	213641	None	0	Human	Binding	pKi	=	7.6	7.6	-6	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		NC(=O)[C@H]1CCCCNC(=O)C[C@H](N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	CHEMBL428326	213436	None	0	Human	Binding	pKi	=	7.6	7.6	-47	4	Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(N)=O	10.1021/jm0501432
	24873537	146059	None	0	Human	Binding	pKi	=	6.6	6.6	-20	4	Binding affinity at human MC5 receptorBinding affinity at human MC5 receptor	ChEMBL	538	6	1	5	4.8	Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1	10.1016/j.bmcl.2007.09.079
	CHEMBL391902	146059	None	0	Human	Binding	pKi	=	6.6	6.6	-20	4	Binding affinity at human MC5 receptorBinding affinity at human MC5 receptor	ChEMBL	538	6	1	5	4.8	Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1	10.1016/j.bmcl.2007.09.079
	11181804	128505	None	0	Human	Binding	pKi	=	6.6	6.6	-21	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	641	11	3	6	4.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	CHEMBL366706	128505	None	0	Human	Binding	pKi	=	6.6	6.6	-21	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	641	11	3	6	4.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	44434562	88696	None	0	Human	Binding	pKi	=	6.6	6.6	-301	3	Displacement of [125I]NDP-MSH from MC5R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC5R receptor in HEK293 cells	ChEMBL	551	10	3	5	3.9	CC(C)C[C@H](N)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL236014	88696	None	0	Human	Binding	pKi	=	6.6	6.6	-301	3	Displacement of [125I]NDP-MSH from MC5R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC5R receptor in HEK293 cells	ChEMBL	551	10	3	5	3.9	CC(C)C[C@H](N)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmc.2007.05.026
	44347378	114433	None	0	Human	Binding	pKi	=	5.6	5.6	-5	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	818	11	11	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NCC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL333262	114433	None	0	Human	Binding	pKi	=	5.6	5.6	-5	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	818	11	11	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NCC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44434843	88698	None	0	Human	Binding	pKi	=	4.6	4.6	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	587	11	4	2	7.6	N=C(N)NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236020	88698	None	0	Human	Binding	pKi	=	4.6	4.6	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	587	11	4	2	7.6	N=C(N)NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434657	90232	None	0	Human	Binding	pKi	=	4.6	4.6	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	389	10	2	3	3.9	NCCCCCN(Cc1ccccc1)C(=O)[C@H](N)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	CHEMBL238341	90232	None	0	Human	Binding	pKi	=	4.6	4.6	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	389	10	2	3	3.9	NCCCCCN(Cc1ccccc1)C(=O)[C@H](N)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	1016	3745	None	78	Human	Binding	pKi	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3745	None	78	Human	Binding	pKi	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3745	None	78	Human	Binding	pKi	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3745	None	78	Human	Binding	pKi	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3745	None	78	Human	Binding	pKi	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3745	None	78	Human	Binding	pKi	=	4.6	4.6	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL2221249	209441	None	0	Human	Binding	pKi	=	6.6	6.6	-1	3	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL		None	None	None		CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O	nan
	168271899	190599	None	0	Human	Binding	pKi	=	7.6	7.6	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	3020	70	35	39	-5.6	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5180727	190599	None	0	Human	Binding	pKi	=	7.6	7.6	-3	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	3020	70	35	39	-5.6	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44433264	89349	None	0	Human	Binding	pKi	=	6.6	6.6	-56	3	Displacement of [125I]NDP-MSH from MC5R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC5R receptor in HEK293 cells	ChEMBL	598	8	1	4	5.9	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL236940	89349	None	0	Human	Binding	pKi	=	6.6	6.6	-56	3	Displacement of [125I]NDP-MSH from MC5R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC5R receptor in HEK293 cells	ChEMBL	598	8	1	4	5.9	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	44347379	114434	None	0	Human	Binding	pKi	=	5.6	5.6	-4	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	750	9	9	7	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NC2CCC(C(N)=O)N2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL333263	114434	None	0	Human	Binding	pKi	=	5.6	5.6	-4	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	750	9	9	7	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NC2CCC(C(N)=O)N2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44265496	97047	None	0	Human	Binding	pKi	=	5.6	5.6	-3	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL267020	97047	None	0	Human	Binding	pKi	=	5.6	5.6	-3	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	9968756	89507	None	0	Human	Binding	pKi	=	4.6	4.6	-15	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	358	5	1	2	3.7	NCCN(C(=O)Cc1ccc2ccccc2c1)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	CHEMBL237299	89507	None	0	Human	Binding	pKi	=	4.6	4.6	-15	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	358	5	1	2	3.7	NCCN(C(=O)Cc1ccc2ccccc2c1)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	10292084	148393	None	0	Human	Binding	pKi	=	4.6	4.6	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	361	6	2	2	3.4	NCCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	CHEMBL393755	148393	None	0	Human	Binding	pKi	=	4.6	4.6	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	361	6	2	2	3.4	NCCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	44434614	151582	None	1	Human	Binding	pKi	=	4.6	4.6	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	349	9	2	2	3.9	NCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL396341	151582	None	1	Human	Binding	pKi	=	4.6	4.6	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	349	9	2	2	3.9	NCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44265496	97047	None	0	Human	Binding	pKi	=	5.6	5.6	-3	4	Binding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki value	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1021/jm020945m
	CHEMBL267020	97047	None	0	Human	Binding	pKi	=	5.6	5.6	-3	4	Binding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki value	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1021/jm020945m
	CHEMBL266417	210681	None	0	Human	Binding	pKi	=	7.6	7.6	-8	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm010165y
	44322868	106006	None	0	Human	Binding	pKi	=	7.6	7.6	-4	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	917	11	12	9	0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL313279	106006	None	0	Human	Binding	pKi	=	7.6	7.6	-4	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	917	11	12	9	0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	11341046	66878	None	0	Human	Binding	pKi	=	7.6	7.6	57	4	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	501	7	4	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N\C2CCNC2)NC2CCCCC2)cc1	10.1021/jm0400496
	CHEMBL186339	66878	None	0	Human	Binding	pKi	=	7.6	7.6	57	4	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	501	7	4	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N\C2CCNC2)NC2CCCCC2)cc1	10.1021/jm0400496
	44394079	126763	None	0	Human	Binding	pKi	=	6.6	6.6	-9	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	653	11	3	5	4.9	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2ccccc2F)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	CHEMBL365278	126763	None	0	Human	Binding	pKi	=	6.6	6.6	-9	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	653	11	3	5	4.9	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2ccccc2F)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	71461657	79037	None	0	Human	Binding	pKi	=	6.6	6.6	4	4	Inhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptor	ChEMBL	556	6	2	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2cccc3c2CCCC3)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.07.035
	CHEMBL2113144	79037	None	0	Human	Binding	pKi	=	6.6	6.6	4	4	Inhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptor	ChEMBL	556	6	2	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2cccc3c2CCCC3)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.07.035
	44434845	147901	None	0	Human	Binding	pKi	=	5.6	5.6	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	527	10	4	2	6.5	N=C(N)NC1CCC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL393350	147901	None	0	Human	Binding	pKi	=	5.6	5.6	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	527	10	4	2	6.5	N=C(N)NC1CCC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	2750	204059	None	76	Human	Binding	pKi	=	4.6	4.6	-15	12	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	CHEMBL7002	204059	None	76	Human	Binding	pKi	=	4.6	4.6	-15	12	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	CHEMBL439128	213823	None	0	Human	Binding	pKi	=	7.6	7.6	-10	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	10033237	69069	None	0	Human	Binding	pKi	=	7.6	7.6	-158	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	789	22	10	7	1.6	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm201226w
	CHEMBL1923662	69069	None	0	Human	Binding	pKi	=	7.6	7.6	-158	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	789	22	10	7	1.6	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm201226w
	CHEMBL2070254	209183	None	0	Human	Binding	pKi	=	6.6	6.6	-7	3	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	11296600	122941	None	0	Human	Binding	pKi	=	6.6	6.6	-41	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	628	9	4	6	3.8	CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	CHEMBL360716	122941	None	0	Human	Binding	pKi	=	6.6	6.6	-41	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	628	9	4	6	3.8	CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	44347106	115058	None	0	Human	Binding	pKi	=	5.6	5.6	-46	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	738	9	10	7	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL334309	115058	None	0	Human	Binding	pKi	=	5.6	5.6	-46	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	738	9	10	7	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44265496	97047	None	0	Human	Binding	pKi	=	5.6	5.6	-3	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL267020	97047	None	0	Human	Binding	pKi	=	5.6	5.6	-3	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	10132207	88649	None	0	Human	Binding	pKi	=	4.6	4.6	-7	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	343	5	2	2	3.9	NCCN(Cc1ccc2ccccc2c1)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235797	88649	None	0	Human	Binding	pKi	=	4.6	4.6	-7	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	343	5	2	2	3.9	NCCN(Cc1ccc2ccccc2c1)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434843	88698	None	0	Human	Binding	pKi	=	4.6	4.6	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	587	11	4	2	7.6	N=C(N)NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236020	88698	None	0	Human	Binding	pKi	=	4.6	4.6	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	587	11	4	2	7.6	N=C(N)NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL268851	210767	None	0	Human	Binding	pKi	=	7.6	7.6	-33	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	168279695	191133	None	0	Human	Binding	pKi	=	7.5	7.5	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	66	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N2)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5188196	191133	None	0	Human	Binding	pKi	=	7.5	7.5	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	66	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N2)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	168285313	191399	None	0	Human	Binding	pKi	=	7.5	7.5	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5192562	191399	None	0	Human	Binding	pKi	=	7.5	7.5	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	6918814	127055	None	1	Human	Binding	pKi	=	6.6	6.6	-58	4	Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	587	12	3	6	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	CHEMBL365597	127055	None	1	Human	Binding	pKi	=	6.6	6.6	-58	4	Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	587	12	3	6	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	58777892	79042	None	0	Human	Binding	pKi	=	6.6	6.6	-4	4	Inhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptor	ChEMBL	599	7	2	5	3.9	CN(C)C1CCc2cccc(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4)NC(=O)[C@H]4Cc5ccccc5CN4)CC3)c2C1	10.1016/j.bmcl.2005.07.035
	CHEMBL2113149	79042	None	0	Human	Binding	pKi	=	6.6	6.6	-4	4	Inhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptor	ChEMBL	599	7	2	5	3.9	CN(C)C1CCc2cccc(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4)NC(=O)[C@H]4Cc5ccccc5CN4)CC3)c2C1	10.1016/j.bmcl.2005.07.035
	44434799	88601	None	0	Human	Binding	pKi	=	4.6	4.6	1	2	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	413	8	4	2	3.8	N=C(N)NCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235592	88601	None	0	Human	Binding	pKi	=	4.6	4.6	1	2	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	413	8	4	2	3.8	N=C(N)NCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434653	145813	None	0	Human	Binding	pKi	=	4.6	4.6	-36	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	437	12	2	2	5.7	NCCCCCN(C/C(Cl)=C\c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL391706	145813	None	0	Human	Binding	pKi	=	4.6	4.6	-36	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	437	12	2	2	5.7	NCCCCCN(C/C(Cl)=C\c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44265347	96965	None	0	Human	Binding	pKi	=	4.6	4.6	-1	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	426	10	4	4	3.3	NCCNC(=O)[C@H](CNCc1ccc2ccccc2c1)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL266305	96965	None	0	Human	Binding	pKi	=	4.6	4.6	-1	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	426	10	4	4	3.3	NCCNC(=O)[C@H](CNCc1ccc2ccccc2c1)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	11192466	66085	None	0	Human	Binding	pKi	=	6.5	6.5	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	577	7	2	3	6.9	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCN(c3ccccc3)CC2)cc1	10.1021/jm0400496
	CHEMBL183842	66085	None	0	Human	Binding	pKi	=	6.5	6.5	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	577	7	2	3	6.9	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCN(c3ccccc3)CC2)cc1	10.1021/jm0400496
	9946241	89430	None	0	Human	Binding	pKi	=	4.5	4.5	-7	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	347	5	2	2	3.1	NCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	CHEMBL237079	89430	None	0	Human	Binding	pKi	=	4.5	4.5	-7	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	347	5	2	2	3.1	NCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	44434687	159490	None	0	Human	Binding	pKi	=	4.5	4.5	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	465	14	2	2	6.5	NCCCCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL410179	159490	None	0	Human	Binding	pKi	=	4.5	4.5	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	465	14	2	2	6.5	NCCCCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	70688853	76922	None	0	Human	Binding	pKi	=	8.5	8.5	-9	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1495	39	18	16	-0.1	CCCCCCCCCCCCCCCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070248	76922	None	0	Human	Binding	pKi	=	8.5	8.5	-9	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1495	39	18	16	-0.1	CCCCCCCCCCCCCCCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	57817763	76925	None	0	Human	Binding	pKi	=	8.5	8.5	-38	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1988	59	26	26	-3.2	CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70690940	76925	None	0	Human	Binding	pKi	=	8.5	8.5	-38	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1988	59	26	26	-3.2	CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929808	76925	None	0	Human	Binding	pKi	=	8.5	8.5	-38	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1988	59	26	26	-3.2	CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070251	76925	None	0	Human	Binding	pKi	=	8.5	8.5	-38	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1988	59	26	26	-3.2	CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	59149255	76926	None	0	Human	Binding	pKi	=	8.5	8.5	-13	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1960	58	24	26	-2.5	CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70693082	76926	None	0	Human	Binding	pKi	=	8.5	8.5	-13	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1960	58	24	26	-2.5	CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929809	76926	None	0	Human	Binding	pKi	=	8.5	8.5	-13	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1960	58	24	26	-2.5	CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070252	76926	None	0	Human	Binding	pKi	=	8.5	8.5	-13	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1960	58	24	26	-2.5	CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	56851059	69072	None	0	Human	Binding	pKi	=	8.4	8.4	1	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	1784	57	24	20	-1.4	C#CCCCC(=O)NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O)C(C)C	10.1021/jm201226w
	57390568	69072	None	0	Human	Binding	pKi	=	8.4	8.4	1	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	1784	57	24	20	-1.4	C#CCCCC(=O)NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O)C(C)C	10.1021/jm201226w
	91930628	69072	None	0	Human	Binding	pKi	=	8.4	8.4	1	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	1784	57	24	20	-1.4	C#CCCCC(=O)NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O)C(C)C	10.1021/jm201226w
	CHEMBL1923668	69072	None	0	Human	Binding	pKi	=	8.4	8.4	1	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	1784	57	24	20	-1.4	C#CCCCC(=O)NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O)C(C)C	10.1021/jm201226w
	168279695	191133	None	0	Human	Binding	pKi	=	7.5	7.5	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	66	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N2)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5188196	191133	None	0	Human	Binding	pKi	=	7.5	7.5	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	66	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N2)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44400864	124323	None	0	Human	Binding	pKi	=	6.5	6.5	-177	3	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	587	11	3	5	5.0	CCNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL363576	124323	None	0	Human	Binding	pKi	=	6.5	6.5	-177	3	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	587	11	3	5	5.0	CCNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	11410616	65272	None	0	Human	Binding	pKi	=	6.5	6.5	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	579	7	2	5	5.7	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCN(c3ncccn3)CC2)cc1	10.1021/jm0400496
	CHEMBL182844	65272	None	0	Human	Binding	pKi	=	6.5	6.5	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	579	7	2	5	5.7	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCN(c3ncccn3)CC2)cc1	10.1021/jm0400496
	44322869	106158	None	0	Human	Binding	pKi	=	5.5	5.5	-28	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	867	11	12	9	-0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL313690	106158	None	0	Human	Binding	pKi	=	5.5	5.5	-28	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	867	11	12	9	-0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	44434603	89911	None	0	Human	Binding	pKi	=	4.5	4.5	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	409	10	2	2	4.9	NCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237935	89911	None	0	Human	Binding	pKi	=	4.5	4.5	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	409	10	2	2	4.9	NCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434686	146598	None	0	Human	Binding	pKi	=	4.5	4.5	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	407	11	3	3	4.7	CC(Cc1ccccc1)CN(CCCCCCN)C(=O)c1cc2cc(O)ccc2[nH]1	10.1016/j.bmc.2007.06.003
	CHEMBL392316	146598	None	0	Human	Binding	pKi	=	4.5	4.5	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	407	11	3	3	4.7	CC(Cc1ccccc1)CN(CCCCCCN)C(=O)c1cc2cc(O)ccc2[nH]1	10.1016/j.bmc.2007.06.003
	23635237	91451	None	0	Human	Binding	pKi	=	6.5	6.5	-53	3	Displacement of [125I]NDP-MSH from human MC5RDisplacement of [125I]NDP-MSH from human MC5R	ChEMBL	498	9	2	4	4.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN)C(C)C)c1	10.1021/jm070806a
	CHEMBL240364	91451	None	0	Human	Binding	pKi	=	6.5	6.5	-53	3	Displacement of [125I]NDP-MSH from human MC5RDisplacement of [125I]NDP-MSH from human MC5R	ChEMBL	498	9	2	4	4.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN)C(C)C)c1	10.1021/jm070806a
	23635237	91451	None	0	Human	Binding	pKi	=	6.5	6.5	-53	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	498	9	2	4	4.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN)C(C)C)c1	10.1016/j.bmc.2008.03.072
	CHEMBL240364	91451	None	0	Human	Binding	pKi	=	6.5	6.5	-53	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	498	9	2	4	4.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN)C(C)C)c1	10.1016/j.bmc.2008.03.072
	44434688	89171	None	0	Human	Binding	pKi	=	5.5	5.5	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	405	13	2	2	5.4	NCCCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236640	89171	None	0	Human	Binding	pKi	=	5.5	5.5	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	405	13	2	2	5.4	NCCCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434690	89304	None	0	Human	Binding	pKi	=	5.5	5.5	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236861	89304	None	0	Human	Binding	pKi	=	5.5	5.5	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434587	89436	None	0	Human	Binding	pKi	=	5.5	5.5	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	391	6	2	3	3.9	NCCN(C(=O)[C@H](N)Cc1ccc(Cl)cc1)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237094	89436	None	0	Human	Binding	pKi	=	5.5	5.5	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	391	6	2	3	3.9	NCCN(C(=O)[C@H](N)Cc1ccc(Cl)cc1)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	44434849	146854	None	0	Human	Binding	pKi	=	4.5	4.5	-16	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	411	9	2	2	5.2	NCc1cccc(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)c1	10.1016/j.bmc.2007.06.003
	CHEMBL392521	146854	None	0	Human	Binding	pKi	=	4.5	4.5	-16	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	411	9	2	2	5.2	NCc1cccc(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)c1	10.1016/j.bmc.2007.06.003
	168295173	192309	None	0	Human	Binding	pKi	=	7.5	7.5	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5206293	192309	None	0	Human	Binding	pKi	=	7.5	7.5	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44562414	176815	None	0	Human	Binding	pKi	=	6.5	6.5	-13	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	532	10	2	5	3.9	CC(C)CC(=O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL460942	176815	None	0	Human	Binding	pKi	=	6.5	6.5	-13	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	532	10	2	5	3.9	CC(C)CC(=O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL2370965	209966	None	0	Human	Binding	pKi	=	5.5	5.5	-2	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	44434597	89611	None	0	Human	Binding	pKi	=	4.5	4.5	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	363	10	2	2	3.9	NCCCN(CCc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237530	89611	None	0	Human	Binding	pKi	=	4.5	4.5	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	363	10	2	2	3.9	NCCCN(CCc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44577093	178644	None	0	Human	Binding	pKi	=	7.5	7.5	-42	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	548	9	2	5	4.7	COc1cc(Cl)ccc1C[C@@H](C)C(=O)N1CCN(c2ccc(Cl)cc2[C@@H](NC(=O)[C@@H](C)N)C(C)C)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL467587	178644	None	0	Human	Binding	pKi	=	7.5	7.5	-42	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	548	9	2	5	4.7	COc1cc(Cl)ccc1C[C@@H](C)C(=O)N1CCN(c2ccc(Cl)cc2[C@@H](NC(=O)[C@@H](C)N)C(C)C)CC1	10.1016/j.bmc.2008.03.072
	23635235	166499	None	0	Human	Binding	pKi	=	6.5	6.5	-223	5	Displacement of [125I]NDP-MSH from human MC5RDisplacement of [125I]NDP-MSH from human MC5R	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1021/jm070806a
	CHEMBL427860	166499	None	0	Human	Binding	pKi	=	6.5	6.5	-223	5	Displacement of [125I]NDP-MSH from human MC5RDisplacement of [125I]NDP-MSH from human MC5R	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1021/jm070806a
	23635236	91599	None	0	Human	Binding	pKi	=	6.5	6.5	-60	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	512	10	2	4	4.6	CNCCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL240780	91599	None	0	Human	Binding	pKi	=	6.5	6.5	-60	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	512	10	2	4	4.6	CNCCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	44434584	151940	None	0	Human	Binding	pKi	=	5.5	5.5	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	394	6	1	3	4.9	NCCN(C(=O)COc1ccc2ccccc2c1)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL396638	151940	None	0	Human	Binding	pKi	=	5.5	5.5	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	394	6	1	3	4.9	NCCN(C(=O)COc1ccc2ccccc2c1)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	10180932	89405	None	0	Human	Binding	pKi	=	4.5	4.5	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	427	11	2	2	5.8	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237051	89405	None	0	Human	Binding	pKi	=	4.5	4.5	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	427	11	2	2	5.8	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434658	90233	None	0	Human	Binding	pKi	=	4.5	4.5	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	389	10	2	3	3.9	NCCCCCN(Cc1ccccc1)C(=O)[C@@H](N)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	CHEMBL238342	90233	None	0	Human	Binding	pKi	=	4.5	4.5	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	389	10	2	3	3.9	NCCCCCN(Cc1ccccc1)C(=O)[C@@H](N)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	10225762	145815	None	0	Human	Binding	pKi	=	4.5	4.5	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	448	14	2	3	5.5	CCN(CC)c1ccc(CN(CCCCCN)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL391707	145815	None	0	Human	Binding	pKi	=	4.5	4.5	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	448	14	2	3	5.5	CCN(CC)c1ccc(CN(CCCCCN)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	2683	102886	None	25	Human	Binding	pKi	=	5.5	5.5	-478	16	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL305906	102886	None	25	Human	Binding	pKi	=	5.5	5.5	-478	16	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL334255	102886	None	25	Human	Binding	pKi	=	5.5	5.5	-478	16	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	44400934	70611	None	0	Human	Binding	pKi	=	6.5	6.5	-173	4	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	587	10	2	5	4.9	CN(C)C(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL194987	70611	None	0	Human	Binding	pKi	=	6.5	6.5	-173	4	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	587	10	2	5	4.9	CN(C)C(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	44400813	71084	None	0	Human	Binding	pKi	=	6.5	6.5	-120	3	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	603	12	4	6	3.9	O=C(NCCO)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL195308	71084	None	0	Human	Binding	pKi	=	6.5	6.5	-120	3	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	603	12	4	6	3.9	O=C(NCCO)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	11785893	67018	None	0	Human	Binding	pKi	=	6.5	6.5	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	530	6	2	3	6.0	CC1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC(C)O1	10.1021/jm0400496
	CHEMBL187022	67018	None	0	Human	Binding	pKi	=	6.5	6.5	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	530	6	2	3	6.0	CC1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC(C)O1	10.1021/jm0400496
	10108894	89735	None	0	Human	Binding	pKi	=	4.5	4.5	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	355	8	2	2	4.4	NCCCCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCCCCC1	10.1016/j.bmc.2007.06.003
	CHEMBL237693	89735	None	0	Human	Binding	pKi	=	4.5	4.5	-5	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	355	8	2	2	4.4	NCCCCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCCCCC1	10.1016/j.bmc.2007.06.003
	44434621	146303	None	0	Human	Binding	pKi	=	4.5	4.5	-11	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	561	9	1	5	6.4	COc1ccc2c(c1)c(CC(=O)N(CCCCN)C13CC4CC(CC(C4)C1)C3)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL392094	146303	None	0	Human	Binding	pKi	=	4.5	4.5	-11	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	561	9	1	5	6.4	COc1ccc2c(c1)c(CC(=O)N(CCCCN)C13CC4CC(CC(C4)C1)C3)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.bmc.2007.06.003
	11477853	66892	None	0	Human	Binding	pKi	=	7.4	7.4	38	3	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	7	3	3	5.2	CNC1CCN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)C1	10.1021/jm0400496
	CHEMBL186439	66892	None	0	Human	Binding	pKi	=	7.4	7.4	38	3	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	7	3	3	5.2	CNC1CCN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)C1	10.1021/jm0400496
	44434568	89174	None	0	Human	Binding	pKi	=	6.4	6.4	-81	3	Displacement of [125I]NDP-MSH from MC5R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC5R receptor in HEK293 cells	ChEMBL	613	8	2	5	4.8	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCNCC2=O)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL236650	89174	None	0	Human	Binding	pKi	=	6.4	6.4	-81	3	Displacement of [125I]NDP-MSH from MC5R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC5R receptor in HEK293 cells	ChEMBL	613	8	2	5	4.8	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCNCC2=O)CC1	10.1016/j.bmc.2007.05.026
	23635236	91599	None	0	Human	Binding	pKi	=	6.4	6.4	-60	3	Displacement of [125I]NDP-MSH from human MC5RDisplacement of [125I]NDP-MSH from human MC5R	ChEMBL	512	10	2	4	4.6	CNCCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1021/jm070806a
	CHEMBL240780	91599	None	0	Human	Binding	pKi	=	6.4	6.4	-60	3	Displacement of [125I]NDP-MSH from human MC5RDisplacement of [125I]NDP-MSH from human MC5R	ChEMBL	512	10	2	4	4.6	CNCCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1021/jm070806a
	11443753	66844	None	0	Human	Binding	pKi	=	6.4	6.4	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	516	10	2	2	7.0	CCCN(CCC)/C(=N/c1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1	10.1021/jm0400496
	CHEMBL186189	66844	None	0	Human	Binding	pKi	=	6.4	6.4	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	516	10	2	2	7.0	CCCN(CCC)/C(=N/c1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1	10.1021/jm0400496
	44434696	149196	None	0	Human	Binding	pKi	=	4.4	4.4	-36	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	609	11	3	3	8.4	NC1CCC(CC2CCC(N(Cc3ccccc3F)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL394394	149196	None	0	Human	Binding	pKi	=	4.4	4.4	-36	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	609	11	3	3	8.4	NC1CCC(CC2CCC(N(Cc3ccccc3F)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44265487	97381	None	0	Human	Binding	pKi	=	4.4	4.4	-1	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	256	6	4	2	1.8	N=C(N)NCCCNCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL269689	97381	None	0	Human	Binding	pKi	=	4.4	4.4	-1	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	256	6	4	2	1.8	N=C(N)NCCCNCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	10025669	97390	None	0	Human	Binding	pKi	=	4.4	4.4	-57	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	429	11	5	4	3.0	NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL269776	97390	None	0	Human	Binding	pKi	=	4.4	4.4	-57	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	429	11	5	4	3.0	NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	25444	155649	None	6	Human	Binding	pKi	=	5.4	5.4	-	1	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	1229	14	17	29	-6.5	C[C@H]1[C@H]2[C@@H](O[C@]13CC[C@@H](C)CO3)[C@@H](O)[C@H]1[C@@H]3CC[C@H]4C[C@@H](O[C@@H]5O[C@H](CO)[C@H](O[C@@H]6O[C@H](CO)C(O)[C@H](O[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O[C@@H]6O[C@H](CO)[C@H](O)[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)C[C@]4(C)[C@H]3CC[C@@]12C	nan
	CHEMBL404811	155649	None	6	Human	Binding	pKi	=	5.4	5.4	-	1	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	1229	14	17	29	-6.5	C[C@H]1[C@H]2[C@@H](O[C@]13CC[C@@H](C)CO3)[C@@H](O)[C@H]1[C@@H]3CC[C@H]4C[C@@H](O[C@@H]5O[C@H](CO)[C@H](O[C@@H]6O[C@H](CO)C(O)[C@H](O[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O[C@@H]6O[C@H](CO)[C@H](O)[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)C[C@]4(C)[C@H]3CC[C@@]12C	nan
	CHEMBL412523	212998	None	0	Human	Binding	pKi	=	7.4	7.4	-125	4	Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	8447	188947	None	84	Human	Binding	pKi	=	5.4	5.4	-50	13	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
	CHEMBL508112	188947	None	84	Human	Binding	pKi	=	5.4	5.4	-50	13	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
	44265711	206987	None	0	Human	Binding	pKi	=	4.4	4.4	-2	4	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	CHEMBL9138	206987	None	0	Human	Binding	pKi	=	4.4	4.4	-2	4	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	44434847	88955	None	0	Human	Binding	pKi	=	4.4	4.4	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	553	11	4	2	7.0	N=C(N)NC1CCC(CC2CCC(N(C/C=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236442	88955	None	0	Human	Binding	pKi	=	4.4	4.4	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	553	11	4	2	7.0	N=C(N)NC1CCC(CC2CCC(N(C/C=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434864	90247	None	0	Human	Binding	pKi	=	4.4	4.4	-13	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	N[C@H]1CC[C@H](NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238369	90247	None	0	Human	Binding	pKi	=	4.4	4.4	-13	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	N[C@H]1CC[C@H](NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)CC1	10.1016/j.bmc.2007.06.003
	3198	205511	None	76	Human	Binding	pKi	=	4.4	4.4	-81	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205511	None	76	Human	Binding	pKi	=	4.4	4.4	-81	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205511	None	76	Human	Binding	pKi	=	4.4	4.4	-81	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	44433439	89922	None	0	Human	Binding	pKi	=	6.4	6.4	-44	3	Binding affinity at human MC5 receptorBinding affinity at human MC5 receptor	ChEMBL	538	6	1	5	4.8	Cc1ccc(N2CCN(C(=O)[C@H]3CN(C4CCOCC4)C[C@@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1	10.1016/j.bmcl.2007.09.079
	CHEMBL237976	89922	None	0	Human	Binding	pKi	=	6.4	6.4	-44	3	Binding affinity at human MC5 receptorBinding affinity at human MC5 receptor	ChEMBL	538	6	1	5	4.8	Cc1ccc(N2CCN(C(=O)[C@H]3CN(C4CCOCC4)C[C@@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1	10.1016/j.bmcl.2007.09.079
	44434684	146597	None	0	Human	Binding	pKi	=	5.4	5.4	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	391	12	2	2	5.0	NCCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL392315	146597	None	0	Human	Binding	pKi	=	5.4	5.4	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	391	12	2	2	5.0	NCCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44265312	205665	None	0	Human	Binding	pKi	=	4.4	4.4	-1	2	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	286	4	2	1	4.6	c1ccc2c(CNCc3c[nH]c4ccccc34)cccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL8208	205665	None	0	Human	Binding	pKi	=	4.4	4.4	-1	2	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	286	4	2	1	4.6	c1ccc2c(CNCc3c[nH]c4ccccc34)cccc2c1	10.1016/s0960-894x(02)00088-4
	51346770	58225	None	0	Human	Binding	pKi	=	6.4	6.4	-3	4	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in BHK cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in BHK cells	ChEMBL	643	11	2	8	3.5	COCC(=O)N[C@H]1Cc2ccc(OC)c(c2)Cc2ccc(cc2)Oc2cccc(c2)CN(CCCN2CCN(CCCN)CC2)C1=O	10.1016/j.bmcl.2011.01.011
	CHEMBL1682209	58225	None	0	Human	Binding	pKi	=	6.4	6.4	-3	4	Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in BHK cellsDisplacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in BHK cells	ChEMBL	643	11	2	8	3.5	COCC(=O)N[C@H]1Cc2ccc(OC)c(c2)Cc2ccc(cc2)Oc2cccc(c2)CN(CCCN2CCN(CCCN)CC2)C1=O	10.1016/j.bmcl.2011.01.011
	44577094	178645	None	0	Human	Binding	pKi	=	6.4	6.4	-117	4	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	546	10	1	4	5.3	CC(C)[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL467588	178645	None	0	Human	Binding	pKi	=	6.4	6.4	-117	4	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	546	10	1	4	5.3	CC(C)[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	44434766	154712	None	0	Human	Binding	pKi	=	5.4	5.4	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	510	9	2	3	6.9	N#Cc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL399810	154712	None	0	Human	Binding	pKi	=	5.4	5.4	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	510	9	2	3	6.9	N#Cc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	44320339	206121	None	0	Human	Binding	pKi	=	5.4	5.4	-2	4	Binding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki value	ChEMBL	410	9	1	2	6.0	NCCCCCC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1021/jm020945m
	CHEMBL85918	206121	None	0	Human	Binding	pKi	=	5.4	5.4	-2	4	Binding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki value	ChEMBL	410	9	1	2	6.0	NCCCCCC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1021/jm020945m
	10025669	97390	None	0	Human	Binding	pKi	=	4.4	4.4	-57	4	Binding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki value	ChEMBL	429	11	5	4	3.0	NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1021/jm020945m
	CHEMBL269776	97390	None	0	Human	Binding	pKi	=	4.4	4.4	-57	4	Binding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 5 receptor, expressed as negative log of the Ki value	ChEMBL	429	11	5	4	3.0	NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1021/jm020945m
	CHEMBL385465	212349	None	0	Human	Binding	pKi	=	8.4	8.4	-44	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CC(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm010165y
	CHEMBL2070244	209182	None	0	Human	Binding	pKi	=	8.4	8.4	-4	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	59149266	76924	None	0	Human	Binding	pKi	=	7.4	7.4	-234	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@@H](N)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70693081	76924	None	0	Human	Binding	pKi	=	7.4	7.4	-234	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@@H](N)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929807	76924	None	0	Human	Binding	pKi	=	7.4	7.4	-234	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@@H](N)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070250	76924	None	0	Human	Binding	pKi	=	7.4	7.4	-234	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@@H](N)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	44347331	16325	None	0	Human	Binding	pKi	=	6.4	6.4	-257	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	CHEMBL122773	16325	None	0	Human	Binding	pKi	=	6.4	6.4	-257	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	44577063	188098	None	0	Human	Binding	pKi	=	6.4	6.4	-74	4	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	544	8	1	4	4.9	CC(C)[C@H](NC(=O)C1CN(C)C1)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL498150	188098	None	0	Human	Binding	pKi	=	6.4	6.4	-74	4	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	544	8	1	4	4.9	CC(C)[C@H](NC(=O)C1CN(C)C1)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	71458055	79026	None	0	Human	Binding	pKi	=	5.4	5.4	-7	4	Inhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptor	ChEMBL	599	6	2	5	3.7	CC(=O)N1CCCc2cccc(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4)NC(=O)[C@H]4Cc5ccccc5CN4)CC3)c21	10.1016/j.bmcl.2005.07.035
	CHEMBL2113133	79026	None	0	Human	Binding	pKi	=	5.4	5.4	-7	4	Inhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptor	ChEMBL	599	6	2	5	3.7	CC(=O)N1CCCc2cccc(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4)NC(=O)[C@H]4Cc5ccccc5CN4)CC3)c21	10.1016/j.bmcl.2005.07.035
	44434689	89173	None	0	Human	Binding	pKi	=	4.4	4.4	-33	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	431	14	2	2	5.9	NCCCCCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236649	89173	None	0	Human	Binding	pKi	=	4.4	4.4	-33	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	431	14	2	2	5.9	NCCCCCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434861	90245	None	0	Human	Binding	pKi	=	4.4	4.4	-9	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	389	7	2	2	4.8	N[C@H]1CC[C@H](N(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238367	90245	None	0	Human	Binding	pKi	=	4.4	4.4	-9	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	389	7	2	2	4.8	N[C@H]1CC[C@H](N(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	168285313	191399	None	0	Human	Binding	pKi	=	7.4	7.4	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5192562	191399	None	0	Human	Binding	pKi	=	7.4	7.4	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44265374	206486	None	0	Human	Binding	pKi	=	5.4	5.4	-2	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	454	10	2	2	6.4	O=C(O)CCCCCNC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL8825	206486	None	0	Human	Binding	pKi	=	5.4	5.4	-2	4	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	454	10	2	2	6.4	O=C(O)CCCCCNC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL415661	213196	None	0	Human	Binding	pKi	=	7.4	7.4	-295	4	Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	10283036	140241	None	0	Human	Binding	pKi	=	6.4	6.4	-72	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	647	11	2	5	5.2	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3C(C)(C)N2)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL380540	140241	None	0	Human	Binding	pKi	=	6.4	6.4	-72	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	647	11	2	5	5.2	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3C(C)(C)N2)CC1	10.1016/j.bmcl.2005.10.103
	44265749	207220	None	0	Human	Binding	pKi	=	4.4	4.4	-4	3	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@H](Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	CHEMBL9274	207220	None	0	Human	Binding	pKi	=	4.4	4.4	-4	3	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@H](Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	44434778	89741	None	0	Human	Binding	pKi	=	4.4	4.4	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237702	89741	None	0	Human	Binding	pKi	=	4.4	4.4	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	10178845	89912	None	0	Human	Binding	pKi	=	5.4	5.4	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	395	8	2	3	3.8	NCCCN(C/C(Cl)=C/c1ccccc1)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237937	89912	None	0	Human	Binding	pKi	=	5.4	5.4	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	395	8	2	3	3.8	NCCCN(C/C(Cl)=C/c1ccccc1)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434762	153008	None	0	Human	Binding	pKi	=	5.4	5.4	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	579	11	2	4	7.7	COc1cc(Cl)c(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL397550	153008	None	0	Human	Binding	pKi	=	5.4	5.4	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	579	11	2	4	7.7	COc1cc(Cl)c(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	44265309	205660	None	1	Human	Binding	pKi	=	4.4	4.4	1	3	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	214	5	2	2	2.3	NCCCNCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL8201	205660	None	1	Human	Binding	pKi	=	4.4	4.4	1	3	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	214	5	2	2	2.3	NCCCNCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	68617	205525	None	62	Human	Binding	pKi	=	5.4	5.4	-21	26	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL1709	205525	None	62	Human	Binding	pKi	=	5.4	5.4	-21	26	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL809	205525	None	62	Human	Binding	pKi	=	5.4	5.4	-21	26	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	11433304	66667	None	0	Human	Binding	pKi	=	7.4	7.4	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	591	8	2	3	6.9	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCN(Cc3ccccc3)CC2)cc1	10.1021/jm0400496
	CHEMBL185398	66667	None	0	Human	Binding	pKi	=	7.4	7.4	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	591	8	2	3	6.9	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCN(Cc3ccccc3)CC2)cc1	10.1021/jm0400496
	44434704	89170	None	0	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	605	11	3	3	8.6	Cc1ccccc1CN(C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236639	89170	None	0	Human	Binding	pKi	=	5.4	5.4	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	605	11	3	3	8.6	Cc1ccccc1CN(C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434780	148170	None	0	Human	Binding	pKi	=	4.4	4.4	-9	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	525	8	2	2	7.3	NC1CCC(CC2CCC(N(C(=O)CCCc3c[nH]c4ccccc34)C3CCc4ccccc4C3)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL393568	148170	None	0	Human	Binding	pKi	=	4.4	4.4	-9	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	525	8	2	2	7.3	NC1CCC(CC2CCC(N(C(=O)CCCc3c[nH]c4ccccc34)C3CCc4ccccc4C3)CC2)CC1	10.1016/j.bmc.2007.06.003
	44265351	205763	None	0	Human	Binding	pKi	=	4.4	4.4	1	3	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	426	8	2	3	4.7	N[C@H](CCC(=O)O)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL8287	205763	None	0	Human	Binding	pKi	=	4.4	4.4	1	3	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	426	8	2	3	4.7	N[C@H](CCC(=O)O)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	56851057	69070	None	0	Human	Binding	pKi	=	7.3	7.3	-190	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	1069	34	13	10	1.3	C#CCCCC(=O)NCCCC[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(N)=O	10.1021/jm201226w
	CHEMBL1923664	69070	None	0	Human	Binding	pKi	=	7.3	7.3	-190	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL	1069	34	13	10	1.3	C#CCCCC(=O)NCCCC[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(N)=O	10.1021/jm201226w
	44434662	88512	None	0	Human	Binding	pKi	=	5.3	5.3	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	377	11	2	2	4.6	NCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235137	88512	None	0	Human	Binding	pKi	=	5.3	5.3	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	377	11	2	2	4.6	NCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434636	89298	None	0	Human	Binding	pKi	=	5.3	5.3	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	469	12	3	3	5.6	NCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236841	89298	None	0	Human	Binding	pKi	=	5.3	5.3	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	469	12	3	3	5.6	NCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434647	89588	None	0	Human	Binding	pKi	=	4.3	4.3	-7	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	421	10	2	2	5.3	NCCCCCN(C(=O)CCCc1c[nH]c2ccccc12)C1C2CC3CC(C2)CC1C3	10.1016/j.bmc.2007.06.003
	CHEMBL237483	89588	None	0	Human	Binding	pKi	=	4.3	4.3	-7	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	421	10	2	2	5.3	NCCCCCN(C(=O)CCCc1c[nH]c2ccccc12)C1C2CC3CC(C2)CC1C3	10.1016/j.bmc.2007.06.003
	44397028	124029	None	0	Human	Binding	pKi	=	6.3	6.3	-61	4	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	631	12	3	6	3.6	COc1cccc(CC(=O)NCC2(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4Cl)NC(=O)CCN)CC3)CCCCC2)c1	10.1016/j.bmcl.2005.05.017
	CHEMBL363019	124029	None	0	Human	Binding	pKi	=	6.3	6.3	-61	4	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	631	12	3	6	3.6	COc1cccc(CC(=O)NCC2(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4Cl)NC(=O)CCN)CC3)CCCCC2)c1	10.1016/j.bmcl.2005.05.017
	44434690	89304	None	0	Human	Binding	pKi	=	4.3	4.3	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236861	89304	None	0	Human	Binding	pKi	=	4.3	4.3	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44265472	206353	None	0	Human	Binding	pKi	=	4.3	4.3	-3	3	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	245	6	5	2	1.1	N=C(N)NCCCNCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL8742	206353	None	0	Human	Binding	pKi	=	4.3	4.3	-3	3	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	245	6	5	2	1.1	N=C(N)NCCCNCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL441760	213894	None	0	Human	Binding	pKi	=	6.3	6.3	-1	2	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	44397030	67367	None	0	Human	Binding	pKi	=	6.3	6.3	-57	4	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	607	11	3	6	3.6	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNC(=O)Cc3cccs3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	CHEMBL188651	67367	None	0	Human	Binding	pKi	=	6.3	6.3	-57	4	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	607	11	3	6	3.6	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNC(=O)Cc3cccs3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	44347105	113344	None	0	Human	Binding	pKi	=	5.3	5.3	-43	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	724	9	10	7	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCC(C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL331728	113344	None	0	Human	Binding	pKi	=	5.3	5.3	-43	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	724	9	10	7	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCC(C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44434854	90027	None	0	Human	Binding	pKi	=	5.3	5.3	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	573	10	2	2	8.6	CC1CC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238153	90027	None	0	Human	Binding	pKi	=	5.3	5.3	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	573	10	2	2	8.6	CC1CC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44434855	90028	None	0	Human	Binding	pKi	=	5.3	5.3	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238154	90028	None	0	Human	Binding	pKi	=	5.3	5.3	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44347082	163906	None	0	Human	Binding	pKi	=	5.3	5.3	-1	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL420727	163906	None	0	Human	Binding	pKi	=	5.3	5.3	-1	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44347081	168625	None	0	Human	Binding	pKi	=	5.3	5.3	-3	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL436169	168625	None	0	Human	Binding	pKi	=	5.3	5.3	-3	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44434772	88595	None	0	Human	Binding	pKi	=	5.3	5.3	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235582	88595	None	0	Human	Binding	pKi	=	5.3	5.3	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434690	89304	None	0	Human	Binding	pKi	=	5.3	5.3	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236861	89304	None	0	Human	Binding	pKi	=	5.3	5.3	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	10109225	154670	None	0	Human	Binding	pKi	=	5.3	5.3	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	361	8	2	3	3.2	NCCCN(C/C=C/c1ccccc1)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL399624	154670	None	0	Human	Binding	pKi	=	5.3	5.3	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	361	8	2	3	3.2	NCCCN(C/C=C/c1ccccc1)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434867	88521	None	0	Human	Binding	pKi	=	4.3	4.3	-22	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	NC1CCCC(NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	CHEMBL235162	88521	None	0	Human	Binding	pKi	=	4.3	4.3	-22	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	NC1CCCC(NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	44434714	148390	None	0	Human	Binding	pKi	=	4.3	4.3	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	486	9	2	3	6.4	NC1CCC(CC2CCC(N(Cc3ccccn3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL393753	148390	None	0	Human	Binding	pKi	=	4.3	4.3	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	486	9	2	3	6.4	NC1CCC(CC2CCC(N(Cc3ccccn3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL2070242	209181	None	0	Human	Binding	pKi	=	8.3	8.3	-1	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	11237444	127463	None	0	Human	Binding	pKi	=	8.3	8.3	245	3	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	503	8	4	3	5.4	CC(C)(N)C/N=C(\Nc1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1	10.1021/jm0400496
	CHEMBL366042	127463	None	0	Human	Binding	pKi	=	8.3	8.3	245	3	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	503	8	4	3	5.4	CC(C)(N)C/N=C(\Nc1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1	10.1021/jm0400496
	11249545	66202	None	0	Human	Binding	pKi	=	8.2	8.2	61	4	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	529	6	3	3	5.6	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)[C@H](C)CN1	10.1021/jm0400496
	CHEMBL184432	66202	None	0	Human	Binding	pKi	=	8.2	8.2	61	4	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	529	6	3	3	5.6	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)[C@H](C)CN1	10.1021/jm0400496
	11752660	66175	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	6	2	3	5.1	CN1CCN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC1	10.1021/jm0400496
	CHEMBL184323	66175	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	6	2	3	5.1	CN1CCN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC1	10.1021/jm0400496
	16007264	79718	None	0	Human	Binding	pKi	=	6.3	6.3	-26	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	572	9	2	4	5.5	CC(C)C[C@H](NC(=O)CN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	CHEMBL211564	79718	None	0	Human	Binding	pKi	=	6.3	6.3	-26	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	572	9	2	4	5.5	CC(C)C[C@H](NC(=O)CN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	16007264	79718	None	0	Human	Binding	pKi	=	6.3	6.3	-26	3	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	572	9	2	4	5.5	CC(C)C[C@H](NC(=O)CN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1021/jm701137s
	CHEMBL211564	79718	None	0	Human	Binding	pKi	=	6.3	6.3	-26	3	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	572	9	2	4	5.5	CC(C)C[C@H](NC(=O)CN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1021/jm701137s
	44347110	114107	None	0	Human	Binding	pKi	=	5.3	5.3	-5	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	681	9	9	7	0.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NCC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL332762	114107	None	0	Human	Binding	pKi	=	5.3	5.3	-5	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	681	9	9	7	0.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NCC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	1338	3805	None	43	Human	Binding	pKi	=	5.3	5.3	-154	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm0311285
	9938402	3805	None	43	Human	Binding	pKi	=	5.3	5.3	-154	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm0311285
	CHEMBL339053	3805	None	43	Human	Binding	pKi	=	5.3	5.3	-154	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm0311285
	44434713	89594	None	0	Human	Binding	pKi	=	5.3	5.3	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	541	11	2	3	7.5	COc1ccccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237502	89594	None	0	Human	Binding	pKi	=	5.3	5.3	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	541	11	2	3	7.5	COc1ccccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434855	90028	None	0	Human	Binding	pKi	=	5.3	5.3	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238154	90028	None	0	Human	Binding	pKi	=	5.3	5.3	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44265713	206829	None	0	Human	Binding	pKi	=	4.3	4.3	-	1	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	364	6	3	4	1.9	O=C(NCCc1c[nH]cn1)[C@@H]1C[C@H](O)CN1Cc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	CHEMBL9048	206829	None	0	Human	Binding	pKi	=	4.3	4.3	-	1	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	364	6	3	4	1.9	O=C(NCCc1c[nH]cn1)[C@@H]1C[C@H](O)CN1Cc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	44434663	88513	None	0	Human	Binding	pKi	=	5.3	5.3	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	483	13	3	3	5.9	NCCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235138	88513	None	0	Human	Binding	pKi	=	5.3	5.3	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	483	13	3	3	5.9	NCCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	24740655	89084	None	0	Human	Binding	pKi	=	6.3	6.3	-891	4	Binding affinity at human MC5RBinding affinity at human MC5R	ChEMBL	643	12	1	5	5.3	Cc1ccc(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3Cl)N3CCCC3=O)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1016/j.bmcl.2007.07.097
	CHEMBL236521	89084	None	0	Human	Binding	pKi	=	6.3	6.3	-891	4	Binding affinity at human MC5RBinding affinity at human MC5R	ChEMBL	643	12	1	5	5.3	Cc1ccc(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3Cl)N3CCCC3=O)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1016/j.bmcl.2007.07.097
	24740655	89084	None	0	Human	Binding	pKi	=	6.3	6.3	-891	4	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	643	12	1	5	5.3	Cc1ccc(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3Cl)N3CCCC3=O)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1021/jm701137s
	CHEMBL236521	89084	None	0	Human	Binding	pKi	=	6.3	6.3	-891	4	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	643	12	1	5	5.3	Cc1ccc(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3Cl)N3CCCC3=O)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1021/jm701137s
	44434760	88515	None	0	Human	Binding	pKi	=	5.3	5.3	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	519	9	2	2	7.6	NC1CCC(CC2CCC(N(Cc3ccccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235140	88515	None	0	Human	Binding	pKi	=	5.3	5.3	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	519	9	2	2	7.6	NC1CCC(CC2CCC(N(Cc3ccccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434764	88558	None	0	Human	Binding	pKi	=	5.3	5.3	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	551	10	2	2	7.8	NC1CCC(CC2CCC(N(CCc3c(F)cccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235358	88558	None	0	Human	Binding	pKi	=	5.3	5.3	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	551	10	2	2	7.8	NC1CCC(CC2CCC(N(CCc3c(F)cccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	10157774	89299	None	0	Human	Binding	pKi	=	5.3	5.3	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	399	9	2	2	5.0	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236842	89299	None	0	Human	Binding	pKi	=	5.3	5.3	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	399	9	2	2	5.0	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434859	90032	None	0	Human	Binding	pKi	=	4.3	4.3	-29	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	NC1CCCC(NC(=O)N[C@H]2CC[C@H](N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)C1	10.1016/j.bmc.2007.06.003
	CHEMBL238158	90032	None	0	Human	Binding	pKi	=	4.3	4.3	-29	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	NC1CCCC(NC(=O)N[C@H]2CC[C@H](N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)C1	10.1016/j.bmc.2007.06.003
	168295173	192309	None	0	Human	Binding	pKi	=	7.3	7.3	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5206293	192309	None	0	Human	Binding	pKi	=	7.3	7.3	1	4	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44456219	155436	None	0	Human	Binding	pKi	=	6.3	6.3	-112	4	Binding affinity to MC5RBinding affinity to MC5R	ChEMBL	637	10	1	6	5.0	Cc1ccc(N2CCN(C(=O)[C@H]3CN(C4CCOCC4)C[C@@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmcl.2007.10.115
	CHEMBL403806	155436	None	0	Human	Binding	pKi	=	6.3	6.3	-112	4	Binding affinity to MC5RBinding affinity to MC5R	ChEMBL	637	10	1	6	5.0	Cc1ccc(N2CCN(C(=O)[C@H]3CN(C4CCOCC4)C[C@@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmcl.2007.10.115
	44347219	16578	None	0	Human	Binding	pKi	=	6.3	6.3	-1071	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	781	9	10	8	0.2	NNC(=O)[C@H]1CCCCNC(=O)CCC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	CHEMBL123938	16578	None	0	Human	Binding	pKi	=	6.3	6.3	-1071	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	781	9	10	8	0.2	NNC(=O)[C@H]1CCCCNC(=O)CCC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	25211670	174258	None	0	Human	Binding	pKi	=	6.3	6.3	-56	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	548	10	2	5	4.0	CC(C)CC(O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CN(C)C)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL454916	174258	None	0	Human	Binding	pKi	=	6.3	6.3	-56	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	548	10	2	5	4.0	CC(C)CC(O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CN(C)C)CC1	10.1016/j.bmcl.2008.07.076
	44562460	189263	None	0	Human	Binding	pKi	=	6.3	6.3	-165	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	533	10	3	5	3.8	CC(C)CC(N)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL511826	189263	None	0	Human	Binding	pKi	=	6.3	6.3	-165	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	533	10	3	5	3.8	CC(C)CC(N)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	6918850	125420	None	1	Human	Binding	pKi	=	6.3	6.3	-154	4	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	631	12	3	6	3.6	COc1ccc(CC(=O)NCC2(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4Cl)NC(=O)CCN)CC3)CCCCC2)cc1	10.1016/j.bmcl.2005.05.017
	CHEMBL364560	125420	None	1	Human	Binding	pKi	=	6.3	6.3	-154	4	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	631	12	3	6	3.6	COc1ccc(CC(=O)NCC2(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4Cl)NC(=O)CCN)CC3)CCCCC2)cc1	10.1016/j.bmcl.2005.05.017
	44434690	89304	None	0	Human	Binding	pKi	=	5.3	5.3	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236861	89304	None	0	Human	Binding	pKi	=	5.3	5.3	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434654	90019	None	0	Human	Binding	pKi	=	5.3	5.3	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	421	10	2	2	5.4	NCCCCCN(C/C(Cl)=C\c1ccccc1)C(=O)/C=C/c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL238134	90019	None	0	Human	Binding	pKi	=	5.3	5.3	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	421	10	2	2	5.4	NCCCCCN(C/C(Cl)=C\c1ccccc1)C(=O)/C=C/c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434665	147947	None	0	Human	Binding	pKi	=	4.3	4.3	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	378	10	3	3	3.2	NCCCCCN(Cc1ccccc1)C(=O)[C@@H](N)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393383	147947	None	0	Human	Binding	pKi	=	4.3	4.3	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	378	10	3	3	3.2	NCCCCCN(Cc1ccccc1)C(=O)[C@@H](N)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434772	88595	None	0	Human	Binding	pKi	=	5.3	5.3	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235582	88595	None	0	Human	Binding	pKi	=	5.3	5.3	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434778	89741	None	0	Human	Binding	pKi	=	5.3	5.3	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237702	89741	None	0	Human	Binding	pKi	=	5.3	5.3	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434595	148870	None	0	Human	Binding	pKi	=	4.3	4.3	-7	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	419	9	2	3	5.6	CC(c1csc2ccccc12)N(CCCN)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL394149	148870	None	0	Human	Binding	pKi	=	4.3	4.3	-7	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	419	9	2	3	5.6	CC(c1csc2ccccc12)N(CCCN)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	6918844	168620	None	1	Human	Binding	pKi	=	6.3	6.3	-173	4	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	606	12	2	6	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)OCCF	10.1016/j.bmcl.2005.03.053
	CHEMBL436122	168620	None	1	Human	Binding	pKi	=	6.3	6.3	-173	4	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	606	12	2	6	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)OCCF	10.1016/j.bmcl.2005.03.053
	11179871	124222	None	0	Human	Binding	pKi	=	6.3	6.3	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	6	3	3	4.5	O=C1CN(/C(=N\C2CCCCC2)Nc2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)CCN1	10.1021/jm0400496
	CHEMBL363440	124222	None	0	Human	Binding	pKi	=	6.3	6.3	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	515	6	3	3	4.5	O=C1CN(/C(=N\C2CCCCC2)Nc2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)CCN1	10.1021/jm0400496
	44434855	90028	None	0	Human	Binding	pKi	=	5.3	5.3	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238154	90028	None	0	Human	Binding	pKi	=	5.3	5.3	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44265591	172041	None	0	Human	Binding	pKi	=	4.3	4.3	-1	3	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	499	12	7	4	2.3	N=C(N)NCCC[C@@H](NCc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(02)00089-6
	CHEMBL447178	172041	None	0	Human	Binding	pKi	=	4.3	4.3	-1	3	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	499	12	7	4	2.3	N=C(N)NCCC[C@@H](NCc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(02)00089-6
	44434634	89297	None	0	Human	Binding	pKi	=	4.3	4.3	-31	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	557	11	1	5	6.5	COc1ccc2c(c1)c(CC(=O)N(CCCCN)C/C(C)=C/c1ccccc1)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL236840	89297	None	0	Human	Binding	pKi	=	4.3	4.3	-31	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	557	11	1	5	6.5	COc1ccc2c(c1)c(CC(=O)N(CCCCN)C/C(C)=C/c1ccccc1)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.bmc.2007.06.003
	44323020	168994	None	0	Human	Binding	pKi	=	5.2	5.2	-741	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	951	11	12	9	1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL439188	168994	None	0	Human	Binding	pKi	=	5.2	5.2	-741	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	951	11	12	9	1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL1923663	209084	None	0	Human	Binding	pKi	=	7.2	7.2	-31	3	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL		None	None	None		CC(=O)N[C@@H](CCc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm201226w
	10134057	88655	None	0	Human	Binding	pKi	=	4.2	4.2	-32	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	375	8	2	3	3.6	C/C(=C\c1ccccc1)CN(CCCN)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235815	88655	None	0	Human	Binding	pKi	=	4.2	4.2	-32	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	375	8	2	3	3.6	C/C(=C\c1ccccc1)CN(CCCN)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	11786860	66332	None	1	Human	Binding	pKi	=	6.2	6.2	-45	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	614	9	4	6	3.4	CC(N[C@H]1CCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	CHEMBL185035	66332	None	1	Human	Binding	pKi	=	6.2	6.2	-45	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	614	9	4	6	3.4	CC(N[C@H]1CCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	44432964	87451	None	0	Human	Binding	pKi	=	5.2	5.2	-1513	3	Displacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cells	ChEMBL	558	14	0	5	7.2	CC(=O)c1ccc(Cc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	CHEMBL233372	87451	None	0	Human	Binding	pKi	=	5.2	5.2	-1513	3	Displacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cells	ChEMBL	558	14	0	5	7.2	CC(=O)c1ccc(Cc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	CHEMBL2370154	209799	None	0	Human	Binding	pKi	=	8.2	8.2	-6	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm020021z
	11215758	66077	None	0	Human	Binding	pKi	=	6.2	6.2	-125	3	Binding affinity for human melanocortin 5 receptorBinding affinity for human melanocortin 5 receptor	ChEMBL	624	9	3	6	5.0	CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2cnc3ccccc3c2)CC1	10.1016/j.bmcl.2004.10.096
	CHEMBL183799	66077	None	0	Human	Binding	pKi	=	6.2	6.2	-125	3	Binding affinity for human melanocortin 5 receptorBinding affinity for human melanocortin 5 receptor	ChEMBL	624	9	3	6	5.0	CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2cnc3ccccc3c2)CC1	10.1016/j.bmcl.2004.10.096
	24180592	97011	None	0	Human	Binding	pKi	=	6.2	6.2	-177	6	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL266647	97011	None	0	Human	Binding	pKi	=	6.2	6.2	-177	6	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	44265708	166817	None	0	Human	Binding	pKi	=	4.2	4.2	-2	2	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@H](Cc1ccc2ccccc2c1)NCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00089-6
	CHEMBL428480	166817	None	0	Human	Binding	pKi	=	4.2	4.2	-2	2	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@H](Cc1ccc2ccccc2c1)NCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00089-6
	CHEMBL11359	9778	None	0	Human	Binding	pKi	=	5.2	5.2	-2	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL		None	None	None		None	nan
	44434821	90026	None	0	Human	Binding	pKi	=	5.2	5.2	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	441	10	4	2	4.5	N=C(N)NCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL238149	90026	None	0	Human	Binding	pKi	=	5.2	5.2	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	441	10	4	2	4.5	N=C(N)NCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL427666	213362	None	0	Human	Binding	pKi	=	7.2	7.2	-22	4	Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CSC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CSC)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(N)=O	10.1021/jm0501432
	44434848	88966	None	0	Human	Binding	pKi	=	5.2	5.2	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	461	9	2	2	6.3	NCc1cccc(CN(Cc2ccc3ccccc3c2)C(=O)CCCc2c[nH]c3ccccc23)c1	10.1016/j.bmc.2007.06.003
	CHEMBL236443	88966	None	0	Human	Binding	pKi	=	5.2	5.2	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	461	9	2	2	6.3	NCc1cccc(CN(Cc2ccc3ccccc3c2)C(=O)CCCc2c[nH]c3ccccc23)c1	10.1016/j.bmc.2007.06.003
	44347840	161922	None	0	Human	Binding	pKi	=	6.2	6.2	-208	3	Inhibitory activity against human melanocortin receptor human Melanocortin 5 receptor was determinedInhibitory activity against human melanocortin receptor human Melanocortin 5 receptor was determined	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	91932630	161922	None	0	Human	Binding	pKi	=	6.2	6.2	-208	3	Inhibitory activity against human melanocortin receptor human Melanocortin 5 receptor was determinedInhibitory activity against human melanocortin receptor human Melanocortin 5 receptor was determined	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL415333	161922	None	0	Human	Binding	pKi	=	6.2	6.2	-208	3	Inhibitory activity against human melanocortin receptor human Melanocortin 5 receptor was determinedInhibitory activity against human melanocortin receptor human Melanocortin 5 receptor was determined	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	44347220	168438	None	0	Human	Binding	pKi	=	7.2	7.2	-251	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	861	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCC(C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL434985	168438	None	0	Human	Binding	pKi	=	7.2	7.2	-251	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	861	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCC(C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44434766	154712	None	0	Human	Binding	pKi	=	5.2	5.2	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	510	9	2	3	6.9	N#Cc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL399810	154712	None	0	Human	Binding	pKi	=	5.2	5.2	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	510	9	2	3	6.9	N#Cc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	44322795	206924	None	0	Human	Binding	pKi	=	6.2	6.2	-114	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	853	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL91041	206924	None	0	Human	Binding	pKi	=	6.2	6.2	-114	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	853	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	44265715	10183	None	0	Human	Binding	pKi	=	5.2	5.2	-2	4	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	439	9	4	3	4.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)Nc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	CHEMBL1159702	10183	None	0	Human	Binding	pKi	=	5.2	5.2	-2	4	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	439	9	4	3	4.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)Nc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	44434856	154390	None	0	Human	Binding	pKi	=	5.2	5.2	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	535	14	2	4	5.0	NCCCN1CCN(CCCN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL398777	154390	None	0	Human	Binding	pKi	=	5.2	5.2	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	535	14	2	4	5.0	NCCCN1CCN(CCCN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	44577091	178665	None	0	Human	Binding	pKi	=	7.2	7.2	-19	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	532	10	2	5	4.0	CNCC(=O)N[C@H](c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2OC)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL467772	178665	None	0	Human	Binding	pKi	=	7.2	7.2	-19	3	Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells	ChEMBL	532	10	2	5	4.0	CNCC(=O)N[C@H](c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2OC)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	44434778	89741	None	0	Human	Binding	pKi	=	5.2	5.2	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237702	89741	None	0	Human	Binding	pKi	=	5.2	5.2	-10	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434651	89898	None	0	Human	Binding	pKi	=	5.2	5.2	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	495	13	3	3	6.1	NCCCCCN(C/C=C\c1ccccc1)C(=O)CCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237911	89898	None	0	Human	Binding	pKi	=	5.2	5.2	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	495	13	3	3	6.1	NCCCCCN(C/C=C\c1ccccc1)C(=O)CCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434698	171023	None	0	Human	Binding	pKi	=	5.2	5.2	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	649	12	3	5	8.1	COC(=O)c1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL445669	171023	None	0	Human	Binding	pKi	=	5.2	5.2	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	649	12	3	5	8.1	COC(=O)c1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	44400863	69162	None	0	Human	Binding	pKi	=	6.2	6.2	-151	3	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	602	11	2	6	5.8	CC(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL192464	69162	None	0	Human	Binding	pKi	=	6.2	6.2	-151	3	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	602	11	2	6	5.8	CC(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	44434855	90028	None	0	Human	Binding	pKi	=	5.2	5.2	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238154	90028	None	0	Human	Binding	pKi	=	5.2	5.2	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44434785	148789	None	0	Human	Binding	pKi	=	5.2	5.2	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	623	11	2	4	7.8	COc1cc(Br)c(CN(C(=O)CCCc2c[nH]c3ccccc23)[C@H]2CC[C@@H](C[C@H]3CC[C@@H](N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL394074	148789	None	0	Human	Binding	pKi	=	5.2	5.2	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	623	11	2	4	7.8	COc1cc(Br)c(CN(C(=O)CCCc2c[nH]c3ccccc23)[C@H]2CC[C@@H](C[C@H]3CC[C@@H](N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	11295934	66973	None	0	Human	Binding	pKi	=	7.2	7.2	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	558	8	3	2	7.1	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N\Cc2cc(F)cc(F)c2)NC2CCCCC2)cc1	10.1021/jm0400496
	CHEMBL186792	66973	None	0	Human	Binding	pKi	=	7.2	7.2	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	558	8	3	2	7.1	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N\Cc2cc(F)cc(F)c2)NC2CCCCC2)cc1	10.1021/jm0400496
	10325955	165269	None	0	Human	Binding	pKi	=	6.2	6.2	-6	4	Binding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	582	8	2	6	3.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2ccnc2)CC1)[C@H]1Cc2ccccc2CN1	10.1021/jm0304109
	CHEMBL423101	165269	None	0	Human	Binding	pKi	=	6.2	6.2	-6	4	Binding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 5 receptor (MC5R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	582	8	2	6	3.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2ccnc2)CC1)[C@H]1Cc2ccccc2CN1	10.1021/jm0304109
	71452732	79032	None	0	Human	Binding	pKi	=	6.2	6.2	1	4	Inhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptor	ChEMBL	697	8	2	6	4.2	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2cccc3c2CN(S(=O)(=O)c2ccccc2)CC3)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.07.035
	CHEMBL2113139	79032	None	0	Human	Binding	pKi	=	6.2	6.2	1	4	Inhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 5 receptor	ChEMBL	697	8	2	6	4.2	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2cccc3c2CN(S(=O)(=O)c2ccccc2)CC3)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.07.035
	44347330	168061	None	0	Human	Binding	pKi	=	5.2	5.2	-1	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL432407	168061	None	0	Human	Binding	pKi	=	5.2	5.2	-1	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	70693083	76927	None	0	Human	Binding	pKi	=	6.2	6.2	-2	3	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1996	61	24	26	-1.3	CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929813	76927	None	0	Human	Binding	pKi	=	6.2	6.2	-2	3	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1996	61	24	26	-1.3	CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070253	76927	None	0	Human	Binding	pKi	=	6.2	6.2	-2	3	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1996	61	24	26	-1.3	CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	24740653	88590	None	0	Human	Binding	pKi	=	6.2	6.2	-190	3	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	540	11	1	4	5.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1021/jm701137s
	CHEMBL235556	88590	None	0	Human	Binding	pKi	=	6.2	6.2	-190	3	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	540	11	1	4	5.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1021/jm701137s
	2726	918	None	68	Human	Binding	pKi	=	5.2	5.2	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	918	None	68	Human	Binding	pKi	=	5.2	5.2	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	918	None	68	Human	Binding	pKi	=	5.2	5.2	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	918	None	68	Human	Binding	pKi	=	5.2	5.2	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	918	None	68	Human	Binding	pKi	=	5.2	5.2	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL407213	212646	None	0	Human	Binding	pKi	=	6.1	6.1	-169	3	Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CC(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm010165y
	11180881	66819	None	1	Human	Binding	pKi	=	6.1	6.1	-47	4	Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	593	11	3	6	4.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)C1CCCNC1	10.1016/j.bmcl.2004.08.055
	CHEMBL186074	66819	None	1	Human	Binding	pKi	=	6.1	6.1	-47	4	Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	593	11	3	6	4.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)C1CCCNC1	10.1016/j.bmcl.2004.08.055
	44434695	89424	None	0	Human	Binding	pKi	=	5.1	5.1	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	503	9	2	2	7.1	NC1CCC(CC2CCC(N(Cc3ccccc3F)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237070	89424	None	0	Human	Binding	pKi	=	5.1	5.1	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	503	9	2	2	7.1	NC1CCC(CC2CCC(N(Cc3ccccc3F)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434768	154713	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	553	9	2	2	8.3	NC1CCC(CC2CCC(N(Cc3c(Cl)cccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL399811	154713	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	553	9	2	2	8.3	NC1CCC(CC2CCC(N(Cc3c(Cl)cccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44400660	70728	None	0	Human	Binding	pKi	=	6.1	6.1	-301	3	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	558	10	2	5	4.8	CC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL195071	70728	None	0	Human	Binding	pKi	=	6.1	6.1	-301	3	Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeledBinding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled	ChEMBL	558	10	2	5	4.8	CC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	44396002	124772	None	0	Human	Binding	pKi	=	6.1	6.1	-17	3	Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	587	11	2	6	4.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)c1cccnc1	10.1016/j.bmcl.2004.08.055
	CHEMBL364215	124772	None	0	Human	Binding	pKi	=	6.1	6.1	-17	3	Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	587	11	2	6	4.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)c1cccnc1	10.1016/j.bmcl.2004.08.055
	10158674	147913	None	0	Human	Binding	pKi	=	5.1	5.1	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	413	10	2	2	5.4	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393359	147913	None	0	Human	Binding	pKi	=	5.1	5.1	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	413	10	2	2	5.4	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44265589	206318	None	0	Human	Binding	pKi	=	4.1	4.1	-2	2	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	499	12	7	4	2.3	N=C(N)NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(02)00089-6
	CHEMBL8720	206318	None	0	Human	Binding	pKi	=	4.1	4.1	-2	2	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	499	12	7	4	2.3	N=C(N)NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(02)00089-6
	44265479	206087	None	0	Human	Binding	pKi	=	4.1	4.1	-1	2	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	268	2	2	2	1.9	N=C(N)N1CCN(Cc2ccc3ccccc3c2)CC1	10.1016/s0960-894x(02)00088-4
	CHEMBL8561	206087	None	0	Human	Binding	pKi	=	4.1	4.1	-1	2	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	268	2	2	2	1.9	N=C(N)N1CCN(Cc2ccc3ccccc3c2)CC1	10.1016/s0960-894x(02)00088-4
	44434713	89594	None	0	Human	Binding	pKi	=	5.1	5.1	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	541	11	2	3	7.5	COc1ccccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237502	89594	None	0	Human	Binding	pKi	=	5.1	5.1	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	541	11	2	3	7.5	COc1ccccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	16172929	212999	None	15	Human	Binding	pKi	=	7.1	7.1	-87	4	Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0501432
	CHEMBL412536	212999	None	15	Human	Binding	pKi	=	7.1	7.1	-87	4	Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0501432
	44434754	90234	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	557	11	3	4	7.2	COc1cc(O)ccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238345	90234	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	557	11	3	4	7.2	COc1cc(O)ccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	11365127	124086	None	0	Human	Binding	pKi	=	7.1	7.1	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	569	7	2	3	6.6	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCC(N3CCCC3)CC2)cc1	10.1021/jm0400496
	CHEMBL363290	124086	None	0	Human	Binding	pKi	=	7.1	7.1	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	569	7	2	3	6.6	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCC(N3CCCC3)CC2)cc1	10.1021/jm0400496
	44434782	90025	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	511	10	2	2	7.5	NC1CCC(CC2CCC(N(C/C=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238144	90025	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	511	10	2	2	7.5	NC1CCC(CC2CCC(N(C/C=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434772	88595	None	0	Human	Binding	pKi	=	5.1	5.1	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235582	88595	None	0	Human	Binding	pKi	=	5.1	5.1	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434637	89410	None	0	Human	Binding	pKi	=	5.1	5.1	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	377	11	2	2	4.3	NCCCCCN(CCCc1ccccc1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237052	89410	None	0	Human	Binding	pKi	=	5.1	5.1	1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	377	11	2	2	4.3	NCCCCCN(CCCc1ccccc1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL409636	212771	None	0	Human	Binding	pKi	=	8.1	8.1	-1	3	Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm030119t
	44456222	97923	None	0	Human	Binding	pKi	=	6.1	6.1	-676	3	Binding affinity to MC5RBinding affinity to MC5R	ChEMBL	637	10	1	6	5.0	Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmcl.2007.10.115
	CHEMBL272538	97923	None	0	Human	Binding	pKi	=	6.1	6.1	-676	3	Binding affinity to MC5RBinding affinity to MC5R	ChEMBL	637	10	1	6	5.0	Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmcl.2007.10.115
	44434666	88557	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	434	9	1	3	5.8	NCCCCCN(C(=O)COc1ccc2ccccc2c1)C1CCC2(CC=CCC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235356	88557	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	434	9	1	3	5.8	NCCCCCN(C(=O)COc1ccc2ccccc2c1)C1CCC2(CC=CCC2)CC1	10.1016/j.bmc.2007.06.003
	44434650	89897	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	389	11	2	2	4.8	NCCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237910	89897	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	389	11	2	2	4.8	NCCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434648	148157	None	0	Human	Binding	pKi	=	5.1	5.1	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	413	10	2	2	5.1	NCCCCCN(CCc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393558	148157	None	0	Human	Binding	pKi	=	5.1	5.1	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	413	10	2	2	5.1	NCCCCCN(CCc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44393421	123101	None	0	Human	Binding	pKi	=	5.1	5.1	-5	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	508	6	2	4	3.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2CCCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL361052	123101	None	0	Human	Binding	pKi	=	5.1	5.1	-5	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	508	6	2	4	3.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2CCCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44434797	88600	None	0	Human	Binding	pKi	=	5.1	5.1	1	2	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	427	9	4	2	4.2	N=C(N)NCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235590	88600	None	0	Human	Binding	pKi	=	5.1	5.1	1	2	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	427	9	4	2	4.2	N=C(N)NCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434691	89423	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	11	2	4	7.0	COc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL237069	89423	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	11	2	4	7.0	COc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	44434770	88559	None	0	Human	Binding	pKi	=	4.1	4.1	-46	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	521	9	2	2	7.3	NC1CCC(CC2CCC(N(Cc3c(F)cccc3F)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235359	88559	None	0	Human	Binding	pKi	=	4.1	4.1	-46	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	521	9	2	2	7.3	NC1CCC(CC2CCC(N(Cc3c(F)cccc3F)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44265473	206354	None	1	Human	Binding	pKi	=	4.1	4.1	-9	2	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	200	4	2	2	1.9	NCCNCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL8743	206354	None	1	Human	Binding	pKi	=	4.1	4.1	-9	2	Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay	ChEMBL	200	4	2	2	1.9	NCCNCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	44434690	89903	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	N[C@H]1CC[C@H](C[C@H]2CC[C@H](N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237920	89903	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	N[C@H]1CC[C@H](C[C@H]2CC[C@H](N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	24180646	148180	None	0	Human	Binding	pKi	=	6.1	6.1	-1202	8	Binding affinity at human MC5RBinding affinity at human MC5R	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL393576	148180	None	0	Human	Binding	pKi	=	6.1	6.1	-1202	8	Binding affinity at human MC5RBinding affinity at human MC5R	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	24180646	148180	None	0	Human	Binding	pKi	=	6.1	6.1	-1202	8	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	CHEMBL393576	148180	None	0	Human	Binding	pKi	=	6.1	6.1	-1202	8	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	44434633	89168	None	0	Human	Binding	pKi	=	4.1	4.1	-35	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	423	11	2	2	5.3	NCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236630	89168	None	0	Human	Binding	pKi	=	4.1	4.1	-35	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	423	11	2	2	5.3	NCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434699	89498	None	0	Human	Binding	pKi	=	4.1	4.1	-26	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	531	10	2	3	7.7	CSc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL237290	89498	None	0	Human	Binding	pKi	=	4.1	4.1	-26	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	531	10	2	3	7.7	CSc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	24741624	138378	None	0	Human	Binding	pKi	=	7.1	7.1	-6	3	Displacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cells	ChEMBL	525	8	1	4	5.9	COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(c2ccc(C(F)(F)F)cc2[C@@H](N)CC(C)C)CC1	10.1016/j.bmcl.2006.06.075
	CHEMBL377231	138378	None	0	Human	Binding	pKi	=	7.1	7.1	-6	3	Displacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cells	ChEMBL	525	8	1	4	5.9	COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(c2ccc(C(F)(F)F)cc2[C@@H](N)CC(C)C)CC1	10.1016/j.bmcl.2006.06.075
	24741624	138378	None	0	Human	Binding	pKi	=	7.1	7.1	-6	3	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	525	8	1	4	5.9	COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(c2ccc(C(F)(F)F)cc2[C@@H](N)CC(C)C)CC1	10.1021/jm701137s
	CHEMBL377231	138378	None	0	Human	Binding	pKi	=	7.1	7.1	-6	3	Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC5R expressed in HEK293 cells	ChEMBL	525	8	1	4	5.9	COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(c2ccc(C(F)(F)F)cc2[C@@H](N)CC(C)C)CC1	10.1021/jm701137s
	1338	3805	None	43	Human	Binding	pKi	=	6.1	6.1	-154	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2004.06.059
	9938402	3805	None	43	Human	Binding	pKi	=	6.1	6.1	-154	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2004.06.059
	CHEMBL339053	3805	None	43	Human	Binding	pKi	=	6.1	6.1	-154	4	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2004.06.059
	44265639	10177	None	0	Human	Binding	pKi	=	5.1	5.1	-6	4	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	439	9	4	3	4.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)Nc1cccc2ccccc12	10.1016/s0960-894x(02)00089-6
	CHEMBL1159697	10177	None	0	Human	Binding	pKi	=	5.1	5.1	-6	4	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	439	9	4	3	4.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)Nc1cccc2ccccc12	10.1016/s0960-894x(02)00089-6
	44434884	88609	None	0	Human	Binding	pKi	=	5.1	5.1	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	417	9	2	2	5.3	NCC1CCCC(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	CHEMBL235617	88609	None	0	Human	Binding	pKi	=	5.1	5.1	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	417	9	2	2	5.3	NCC1CCCC(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	44434690	89304	None	0	Human	Binding	pKi	=	5.1	5.1	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236861	89304	None	0	Human	Binding	pKi	=	5.1	5.1	-8	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434655	90020	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	417	12	2	2	5.6	C/C(=C/c1ccccc1)CN(CCCCCN)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL238135	90020	None	0	Human	Binding	pKi	=	5.1	5.1	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	417	12	2	2	5.6	C/C(=C/c1ccccc1)CN(CCCCCN)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	10260053	168201	None	0	Human	Binding	pKi	=	6.1	6.1	-6	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	871	27	12	10	-1.1	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm020021z
	CHEMBL433413	168201	None	0	Human	Binding	pKi	=	6.1	6.1	-6	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	871	27	12	10	-1.1	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm020021z
	44432932	87752	None	0	Human	Binding	pKi	=	6.1	6.1	-263	4	Displacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cells	ChEMBL	574	14	2	6	6.6	CNC(=O)c1ccc(Nc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	CHEMBL233758	87752	None	0	Human	Binding	pKi	=	6.1	6.1	-263	4	Displacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 5 receptor expressed in CHOK1 cells	ChEMBL	574	14	2	6	6.6	CNC(=O)c1ccc(Nc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	44434700	149507	None	0	Human	Binding	pKi	=	5.1	5.1	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	637	12	3	4	9.0	CSc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL394645	149507	None	0	Human	Binding	pKi	=	5.1	5.1	-1	3	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	637	12	3	4	9.0	CSc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	44434762	153008	None	0	Human	Binding	pKi	=	5.1	5.1	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	579	11	2	4	7.7	COc1cc(Cl)c(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL397550	153008	None	0	Human	Binding	pKi	=	5.1	5.1	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	579	11	2	4	7.7	COc1cc(Cl)c(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	10155513	151539	None	0	Human	Binding	pKi	=	4.1	4.1	-9	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	361	8	2	2	4.0	C/C(=C\c1ccccc1)CN(CCCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL396303	151539	None	0	Human	Binding	pKi	=	4.1	4.1	-9	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	361	8	2	2	4.0	C/C(=C\c1ccccc1)CN(CCCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	176	398	None	66	Human	Binding	pKi	=	5.1	5.1	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	398	None	66	Human	Binding	pKi	=	5.1	5.1	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	398	None	66	Human	Binding	pKi	=	5.1	5.1	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	398	None	66	Human	Binding	pKi	=	5.1	5.1	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	398	None	66	Human	Binding	pKi	=	5.1	5.1	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	1212	1660	None	50	Human	Binding	pKi	=	5.1	5.1	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1660	None	50	Human	Binding	pKi	=	5.1	5.1	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1660	None	50	Human	Binding	pKi	=	5.1	5.1	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1660	None	50	Human	Binding	pKi	=	5.1	5.1	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1660	None	50	Human	Binding	pKi	=	5.1	5.1	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	1324	302	None	25	Human	Binding	pKi	=	8	8.0	-6	4	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL		None	None	None		None	10.1021/jm201226w
	16154396	302	None	25	Human	Binding	pKi	=	8	8.0	-6	4	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL		None	None	None		None	10.1021/jm201226w
	16197727	302	None	25	Human	Binding	pKi	=	8	8.0	-6	4	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL		None	None	None		None	10.1021/jm201226w
	44285019	302	None	25	Human	Binding	pKi	=	8	8.0	-6	4	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL		None	None	None		None	10.1021/jm201226w
	57514683	302	None	25	Human	Binding	pKi	=	8	8.0	-6	4	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL		None	None	None		None	10.1021/jm201226w
	91898441	302	None	25	Human	Binding	pKi	=	8	8.0	-6	4	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL		None	None	None		None	10.1021/jm201226w
	CHEMBL441738	302	None	25	Human	Binding	pKi	=	8	8.0	-6	4	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL		None	None	None		None	10.1021/jm201226w
	DB04931	302	None	25	Human	Binding	pKi	=	8	8.0	-6	4	Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisDisplacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis	ChEMBL		None	None	None		None	10.1021/jm201226w
	11318528	66253	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	528	7	2	2	7.1	CN(/C(=N/c1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1)C1CCCCC1	10.1021/jm0400496
	CHEMBL184612	66253	None	0	Human	Binding	pKi	=	7.0	7.0	-	1	Inhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cellsInhibition of [125I]NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK293 cells	ChEMBL	528	7	2	2	7.1	CN(/C(=N/c1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1)C1CCCCC1	10.1021/jm0400496
	44410803	140170	None	0	Human	Binding	pKi	=	6.0	6.0	-87	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	633	12	2	5	5.0	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2NCCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL380365	140170	None	0	Human	Binding	pKi	=	6.0	6.0	-87	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	633	12	2	5	5.0	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2NCCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	44434880	88608	None	0	Human	Binding	pKi	=	5.0	5.0	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	477	10	2	2	6.4	NCC1CCCC(CN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	CHEMBL235616	88608	None	0	Human	Binding	pKi	=	5.0	5.0	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	477	10	2	2	6.4	NCC1CCCC(CN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	44434709	89773	None	0	Human	Binding	pKi	=	5.0	5.0	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	563	9	2	2	7.7	NC1CCC(CC2CCC(N(Cc3ccccc3Br)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237714	89773	None	0	Human	Binding	pKi	=	5.0	5.0	-2	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	563	9	2	2	7.7	NC1CCC(CC2CCC(N(Cc3ccccc3Br)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434854	90027	None	0	Human	Binding	pKi	=	5.0	5.0	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	573	10	2	2	8.6	CC1CC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238153	90027	None	0	Human	Binding	pKi	=	5.0	5.0	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	573	10	2	2	8.6	CC1CC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44434787	148790	None	0	Human	Binding	pKi	=	5.0	5.0	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	729	13	3	5	9.1	COc1cc(Br)c(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)[C@H]2CC[C@@H](C[C@H]3CC[C@H](N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL394075	148790	None	0	Human	Binding	pKi	=	5.0	5.0	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	729	13	3	5	9.1	COc1cc(Br)c(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)[C@H]2CC[C@@H](C[C@H]3CC[C@H](N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	44434605	149512	None	0	Human	Binding	pKi	=	4.0	4.0	-13	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	356	10	1	3	4.4	C/C(=C\c1ccccc1)CN(CCCN)C(=O)CCCc1cccs1	10.1016/j.bmc.2007.06.003
	CHEMBL394647	149512	None	0	Human	Binding	pKi	=	4.0	4.0	-13	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	356	10	1	3	4.4	C/C(=C\c1ccccc1)CN(CCCN)C(=O)CCCc1cccs1	10.1016/j.bmc.2007.06.003
	10304463	76772	None	0	Human	Binding	pKi	=	6.0	6.0	-9	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	615	11	1	5	5.6	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2cc3ccccc3cn2)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL206840	76772	None	0	Human	Binding	pKi	=	6.0	6.0	-9	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	615	11	1	5	5.6	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2cc3ccccc3cn2)CC1	10.1016/j.bmcl.2005.10.103
	44397198	66763	None	0	Human	Binding	pKi	=	6.0	6.0	-120	3	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	601	11	3	5	3.6	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNC(=O)Cc3ccccc3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	CHEMBL185862	66763	None	0	Human	Binding	pKi	=	6.0	6.0	-120	3	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells	ChEMBL	601	11	3	5	3.6	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNC(=O)Cc3ccccc3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	10291370	145964	None	0	Human	Binding	pKi	=	6.0	6.0	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	347	7	2	2	4.1	C/C(=C\c1ccccc1)CN(CCCN)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL391823	145964	None	0	Human	Binding	pKi	=	6.0	6.0	-1	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	347	7	2	2	4.1	C/C(=C\c1ccccc1)CN(CCCN)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434772	88595	None	0	Human	Binding	pKi	=	5.0	5.0	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235582	88595	None	0	Human	Binding	pKi	=	5.0	5.0	-6	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44393450	123652	None	0	Human	Binding	pKi	=	4.0	4.0	-2	3	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	518	6	2	4	3.4	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CC[N+]([O-])(c2ccccc2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL362010	123652	None	0	Human	Binding	pKi	=	4.0	4.0	-2	3	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	518	6	2	4	3.4	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CC[N+]([O-])(c2ccccc2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44562287	174246	None	0	Human	Binding	pKi	=	6.0	6.0	-102	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	548	10	2	5	3.9	CCC(O)(CC)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CN(C)C)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL454900	174246	None	0	Human	Binding	pKi	=	6.0	6.0	-102	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	548	10	2	5	3.9	CCC(O)(CC)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CN(C)C)CC1	10.1016/j.bmcl.2008.07.076
	6918857	138707	None	1	Human	Binding	pKi	=	6.0	6.0	-33	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	619	11	2	5	4.4	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL377961	138707	None	1	Human	Binding	pKi	=	6.0	6.0	-33	4	Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell	ChEMBL	619	11	2	5	4.4	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.10.103
	44434693	167345	None	0	Human	Binding	pKi	=	5.0	5.0	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	559	12	2	4	7.4	CCOc1cc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)ccc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL429451	167345	None	0	Human	Binding	pKi	=	5.0	5.0	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	559	12	2	4	7.4	CCOc1cc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)ccc1OC	10.1016/j.bmc.2007.06.003
	44265719	207128	None	0	Human	Binding	pKi	=	4.0	4.0	-1	2	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@@H](Cc1ccc2ccccc2c1)NCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00089-6
	CHEMBL9219	207128	None	0	Human	Binding	pKi	=	4.0	4.0	-1	2	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 5 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@@H](Cc1ccc2ccccc2c1)NCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00089-6
	44434697	148691	None	0	Human	Binding	pKi	=	5.0	5.0	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	543	10	2	4	6.8	COC(=O)c1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL393994	148691	None	0	Human	Binding	pKi	=	5.0	5.0	-4	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	543	10	2	4	6.8	COC(=O)c1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	44434759	88514	None	0	Human	Binding	pKi	=	4.0	4.0	-23	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	486	9	2	3	6.4	NC1CCC(CC2CCC(N(Cc3ccncc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235139	88514	None	0	Human	Binding	pKi	=	4.0	4.0	-23	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	486	9	2	3	6.4	NC1CCC(CC2CCC(N(Cc3ccncc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	25058412	189438	None	0	Human	Binding	pKi	=	6.0	6.0	-120	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	534	10	3	5	3.8	CC(C)CC(O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL513404	189438	None	0	Human	Binding	pKi	=	6.0	6.0	-120	3	Binding affinity to MC5 receptorBinding affinity to MC5 receptor	ChEMBL	534	10	3	5	3.8	CC(C)CC(O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	44434851	89907	None	0	Human	Binding	pKi	=	5.0	5.0	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	437	10	2	2	5.7	NCc1ccc(CN(C/C=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL237930	89907	None	0	Human	Binding	pKi	=	5.0	5.0	-3	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	437	10	2	2	5.7	NCc1ccc(CN(C/C=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	44434761	89165	None	0	Human	Binding	pKi	=	4.0	4.0	-14	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	625	11	3	3	8.9	NC1CCC(CC2CCC(N(Cc3ccccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236626	89165	None	0	Human	Binding	pKi	=	4.0	4.0	-14	4	Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells	ChEMBL	625	11	3	3	8.9	NC1CCC(CC2CCC(N(Cc3ccccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	10257541	126340	None	0	Human	Binding	pKi	=	5.0	5.0	-602	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	575	7	2	7	3.0	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN([C@@H]2CCCC[C@H]2n2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL365039	126340	None	0	Human	Binding	pKi	=	5.0	5.0	-602	4	Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH	ChEMBL	575	7	2	7	3.0	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN([C@@H]2CCCC[C@H]2n2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	46877881	201816	None	0	Human	Binding	pKi	=	6	6.0	-5	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	813	9	10	8	-0.3	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL606990	201816	None	0	Human	Binding	pKi	=	6	6.0	-5	3	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsBinding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL	813	9	10	8	-0.3	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	11296732	143811	None	0	Human	Binding	pKi	=	6	6.0	-22	3	Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	539	11	3	6	3.1	NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	CHEMBL390130	143811	None	0	Human	Binding	pKi	=	6	6.0	-22	3	Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	539	11	3	6	3.1	NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	23661656	169042	None	0	Human	Binding	pKi	=	6	6.0	-181	5	Displacement of [125I]NDP-MSH from MC5R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC5R receptor in HEK293 cells	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL439560	169042	None	0	Human	Binding	pKi	=	6	6.0	-181	5	Displacement of [125I]NDP-MSH from MC5R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC5R receptor in HEK293 cells	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	11296732	143811	None	0	Human	Binding	pKi	=	6	6.0	-22	3	Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	539	11	3	6	3.1	NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	CHEMBL390130	143811	None	0	Human	Binding	pKi	=	6	6.0	-22	3	Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cells	ChEMBL	539	11	3	6	3.1	NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	1329	314	None	0	Mouse	Binding	pKd	None	4.9	4.9	-5011	3	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9454589
	1320	366	None	0	Human	Binding	pKd	None	6.9	6.9	-19	3	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	16162729	366	None	0	Human	Binding	pKd	None	6.9	6.9	-19	3	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	1328	1941	None	0	Human	Binding	pKd	None	8.5	8.5	-10	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9832440
	1325	3598	None	14	Human	Binding	pKd	None	9	9.0	-15	7	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10657491
	6440621	3598	None	14	Human	Binding	pKd	None	9	9.0	-15	7	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10657491
	9898183	3598	None	14	Human	Binding	pKd	None	9	9.0	-15	7	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10657491
	CHEMBL3422426	3598	None	14	Human	Binding	pKd	None	9	9.0	-15	7	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10657491
	None	216307	125I-NDP-MSH	0	Human	Binding	pKi	=	5	5.0	-8511	4	NoneNone	PDSP KiDatabase	299	5	3	6	-0.3	CC(C)C(C(C)O)(C(=O)OCC1=CCN2C1C(CC2)O)O	None
	None	216307	125I-[Nle4,D-Phe7]Alpha-MSH	0	Human	Binding	pKi	=	5	5.0	-8511	4	NoneNone	PDSP KiDatabase	299	5	3	6	-0.3	CC(C)C(C(C)O)(C(=O)OCC1=CCN2C1C(CC2)O)O	None
	None	216308	125I-NDP-MSH	0	Human	Binding	pKi	=	5	5.0	-93	4	NoneNone	PDSP KiDatabase	961	29	13	12	-1.5	CSCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)O)N	None
	None	216308	125I-[Nle4,D-Phe7]Alpha-MSH	0	Human	Binding	pKi	=	5	5.0	-93	4	NoneNone	PDSP KiDatabase	961	29	13	12	-1.5	CSCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)O)N	None
	3198	205511	None	76	Human	Binding	pKi	=	8.4	8.4	-81	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL1201049	205511	None	76	Human	Binding	pKi	=	8.4	8.4	-81	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL808	205511	None	76	Human	Binding	pKi	=	8.4	8.4	-81	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	1016	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2561	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2733526	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	5384	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	CHEMBL83	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	DB00675	3745	None	78	Human	Binding	pKi	=	8.3	8.3	-66	35	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	4189	206920	None	96	Human	Binding	pKi	=	8.3	8.3	-61	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL1559	206920	None	96	Human	Binding	pKi	=	8.3	8.3	-61	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL91	206920	None	96	Human	Binding	pKi	=	8.3	8.3	-61	34	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	138106885	166909	None	75	Human	Binding	pKi	=	8.3	8.3	-3	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	None
	36314	166909	None	75	Human	Binding	pKi	=	8.3	8.3	-3	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	None
	CHEMBL428647	166909	None	75	Human	Binding	pKi	=	8.3	8.3	-3	4	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	None
	176	398	None	66	Human	Binding	pKi	=	8.3	8.3	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2157	398	None	66	Human	Binding	pKi	=	8.3	8.3	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2566	398	None	66	Human	Binding	pKi	=	8.3	8.3	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	CHEMBL633	398	None	66	Human	Binding	pKi	=	8.3	8.3	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	DB01118	398	None	66	Human	Binding	pKi	=	8.3	8.3	-5	31	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	1212	1660	None	50	Human	Binding	pKi	=	8.3	8.3	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1660	None	50	Human	Binding	pKi	=	8.3	8.3	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1660	None	50	Human	Binding	pKi	=	8.3	8.3	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1660	None	50	Human	Binding	pKi	=	8.3	8.3	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1660	None	50	Human	Binding	pKi	=	8.3	8.3	-416	66	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2726	918	None	68	Human	Binding	pKi	=	8.3	8.3	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	918	None	68	Human	Binding	pKi	=	8.3	8.3	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	918	None	68	Human	Binding	pKi	=	8.3	8.3	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	918	None	68	Human	Binding	pKi	=	8.3	8.3	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	918	None	68	Human	Binding	pKi	=	8.3	8.3	-112	73	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	68617	205525	None	62	Human	Binding	pKi	=	8.3	8.3	-21	26	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL1709	205525	None	62	Human	Binding	pKi	=	8.3	8.3	-21	26	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL809	205525	None	62	Human	Binding	pKi	=	8.3	8.3	-21	26	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	2247	505	None	81	Human	Binding	pKi	=	8.3	8.3	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	249	505	None	81	Human	Binding	pKi	=	8.3	8.3	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	2603	505	None	81	Human	Binding	pKi	=	8.3	8.3	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	CHEMBL296419	505	None	81	Human	Binding	pKi	=	8.3	8.3	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	DB00637	505	None	81	Human	Binding	pKi	=	8.3	8.3	-63	42	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	11993702	3591	None	18	Human	Binding	pKi	=	8.2	8.2	-19	5	NoneNone	Drug Central		None	None	None		None	None
	5416	3591	None	18	Human	Binding	pKi	=	8.2	8.2	-19	5	NoneNone	Drug Central		None	None	None		None	None
	9272	3591	None	18	Human	Binding	pKi	=	8.2	8.2	-19	5	NoneNone	Drug Central		None	None	None		None	None
	CHEMBL3301624	3591	None	18	Human	Binding	pKi	=	8.2	8.2	-19	5	NoneNone	Drug Central		None	None	None		None	None
	DB11700	3591	None	18	Human	Binding	pKi	=	8.2	8.2	-19	5	NoneNone	Drug Central		None	None	None		None	None
	10408	719	None	28	Human	Binding	pKi	=	8.1	8.1	-3	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	Drug Central		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	None
	5329	719	None	28	Human	Binding	pKi	=	8.1	8.1	-3	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	Drug Central		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	None
	9941379	719	None	28	Human	Binding	pKi	=	8.1	8.1	-3	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	Drug Central		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	None
	CHEMBL2070241	719	None	28	Human	Binding	pKi	=	8.1	8.1	-3	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	Drug Central		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	None
	DB11653	719	None	28	Human	Binding	pKi	=	8.1	8.1	-3	4	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin	Drug Central		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	None
	10408	719	None	28	Human	Binding	pKi	=	7.8	7.8	-3	4	Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>5</sub> receptor.Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>5</sub> receptor.	Guide to Pharmacology		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	22335602
	5329	719	None	28	Human	Binding	pKi	=	7.8	7.8	-3	4	Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>5</sub> receptor.Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>5</sub> receptor.	Guide to Pharmacology		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	22335602
	9941379	719	None	28	Human	Binding	pKi	=	7.8	7.8	-3	4	Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>5</sub> receptor.Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>5</sub> receptor.	Guide to Pharmacology		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	22335602
	CHEMBL2070241	719	None	28	Human	Binding	pKi	=	7.8	7.8	-3	4	Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>5</sub> receptor.Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>5</sub> receptor.	Guide to Pharmacology		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	22335602
	DB11653	719	None	28	Human	Binding	pKi	=	7.8	7.8	-3	4	Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>5</sub> receptor.Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>5</sub> receptor.	Guide to Pharmacology		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	22335602
	11993702	3591	None	18	Human	Binding	pKi	=	6.4	6.4	-19	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19646498
	5416	3591	None	18	Human	Binding	pKi	=	6.4	6.4	-19	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19646498
	9272	3591	None	18	Human	Binding	pKi	=	6.4	6.4	-19	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19646498
	CHEMBL3301624	3591	None	18	Human	Binding	pKi	=	6.4	6.4	-19	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19646498
	DB11700	3591	None	18	Human	Binding	pKi	=	6.4	6.4	-19	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19646498
	134611880	277	None	0	Human	Binding	pKi	>	5	5.0	-2187	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675
	16132265	277	None	0	Human	Binding	pKi	>	5	5.0	-2187	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675
	3633	277	None	0	Human	Binding	pKi	>	5	5.0	-2187	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675
	4931	277	None	0	Human	Binding	pKi	>	5	5.0	-2187	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675
	CHEMBL1201610	277	None	0	Human	Binding	pKi	>	5	5.0	-2187	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675
	DB01285	277	None	0	Human	Binding	pKi	>	5	5.0	-2187	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675

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Ligand source activities (1 row/activity)