V2 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7KH0

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41422-021-00483-Z

PUBLICATION DATE

May 26, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

73 interactions (Click to see)

LIGANDS

vasopressin - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

oxytocin, vasopressin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 P 73 2x38 G.H5 Y 391 G.H5.23
Van-der-waals TM2 P 73 2x38 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 140 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 140 3x53 G.H5 Y 391 G.H5.23
Polar ICL2 Y 148 - G.H5 H 387 G.H5.19
Hydrophobic H8 S 330 8x48 G.H5 E 392 G.H5.24
Polar TM5 S 235 5x68 G.H5 Q 384 G.H5.16
Polar TM3 A 140 3x53 G.H5 H 387 G.H5.19
Polar ICL2 R 149 - G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL3 P 240 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 P 240 - G.h4s6 Y 358 G.h4s6.20
Polar TM3 D 136 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 136 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 228 5x61 G.H5 L 393 G.H5.25
Polar TM6 K 268 6x32 G.H5 E 392 G.H5.24
Polar ICL3 S 241 - G.H4 R 342 G.H4.12
Hydrophobic TM6 K 268 6x32 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 144 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 M 145 - G.H5 I 383 G.H5.15
Hydrophobic TM3 R 137 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL3 P 240 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 P 240 - G.S6 Y 360 G.S6.02
Hydrophobic TM6 A 265 6x29 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 265 6x29 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 141 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 144 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 144 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 M 145 - G.H5 R 380 G.H5.12
Polar TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 R 149 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 M 145 - G.S3 F 219 G.S3.03
Ionic TM5 E 231 5x64 G.H5 R 380 G.H5.12
Aromatic ICL2 Y 148 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 Y 148 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 Y 148 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 M 145 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 M 145 - G.H5 F 376 G.H5.08
Polar TM5 S 235 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM3 I 141 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 M 145 - G.S1 H 41 G.S1.02
Hydrophobic TM6 A 264 6x28 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 144 - G.H5 Q 384 G.H5.16
Hydrophobic TM6 A 265 6x29 G.H5 L 388 G.H5.20
Polar TM3 C 142 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM5 I 232 5x65 G.H5 L 388 G.H5.20
Polar TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM2 I 74 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 M 145 - G.S3 V 217 G.S3.01
Hydrophobic TM6 A 265 6x29 G.H5 L 394 G.H5.26
Polar TM5 G 239 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 I 232 5x65 G.H5 L 393 G.H5.25
Hydrophobic ICL2 R 149 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 149 - G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 Y 148 - G.H5 I 383 G.H5.15