Y1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Feb. 23, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

neuropeptide Y, peptide YY, pancreatic polypeptide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 I 142 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.25
Polar TM3 L 141 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 M 245 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 M 245 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 234 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 237 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 237 5x64 G.H5 I 344 G.H5.16
Hydrophobic C-term K 325 - G.H5 F 354 G.H5.26
Hydrophobic TM5 L 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 Y 253 6x25 G.h4s6 D 315 G.h4s6.09
Ionic TM6 R 254 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 M 245 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 M 245 5x72 G.H5 D 337 G.H5.09
Hydrophobic ICL2 P 145 - G.H5 I 343 G.H5.15
Hydrophobic TM3 I 142 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 238 5x65 G.H5 L 353 G.H5.25
Polar TM6 R 260 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 260 6x32 G.H5 L 353 G.H5.25
Polar TM6 R 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 260 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic C-term N 324 - G.H5 G 352 G.H5.24
Van-der-waals C-term N 324 - G.H5 G 352 G.H5.24
Van-der-waals ICL2 P 145 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 R 146 - G.H5 T 340 G.H5.12
Polar ICL2 R 149 - G.H5 N 347 G.H5.19
Hydrophobic TM6 E 257 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 E 257 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 R 146 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 R 146 - G.H5 F 336 G.H5.08
Hydrophobic TM6 I 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 261 6x33 G.H5 L 353 G.H5.25
Ionic ICL2 R 149 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 145 - G.H5 I 344 G.H5.16
Hydrophobic TM6 L 265 6x37 G.H5 L 353 G.H5.25