Refined structure (7BZ2) of Gs - β2-adrenoceptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 198 from structure (50.3%), 196 from model (49.7%)
Residue sidechains - 171 from structure (43.4%), 223 from model (56.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 Structure Structure
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure AF2
G.HN 14 N G.HN.31 Structure AF2
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure AF2
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure AF2
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure AF2
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure AF2
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure AF2
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure AF2
G.H1 58 K G.H1.06 Structure AF2
G.H1 59 Q G.H1.07 AF2 AF2
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 AF2 AF2
G.hfs2 206 G G.hfs2.07 AF2 AF2
G.S2 207 I G.S2.01 AF2 AF2
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure AF2
G.S2 210 T G.S2.04 Structure AF2
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure AF2
G.H2 229 D G.H2.02 Structure AF2
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure AF2
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 AF2 AF2
G.s4h3 251 S G.s4h3.02 AF2 AF2
G.s4h3 252 S G.s4h3.03 AF2 AF2
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 AF2 AF2
G.HG 296 L G.HG.03 AF2 AF2
G.HG 297 L G.HG.04 AF2 AF2
G.HG 298 A G.HG.05 AF2 AF2
G.HG 299 E G.HG.06 AF2 AF2
G.HG 300 K G.HG.07 AF2 AF2
G.HG 301 V G.HG.08 AF2 AF2
G.HG 302 L G.HG.09 AF2 AF2
G.HG 303 A G.HG.10 AF2 AF2
G.HG 304 G G.HG.11 AF2 AF2
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 AF2 AF2
G.HG 307 K G.HG.14 AF2 AF2
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure AF2
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure AF2
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 AF2 AF2
G.hgh4 322 E G.hgh4.12 AF2 AF2
G.hgh4 323 D G.hgh4.13 AF2 AF2
G.hgh4 324 A G.hgh4.14 AF2 AF2
G.hgh4 325 T G.hgh4.15 AF2 AF2
G.hgh4 326 P G.hgh4.16 AF2 AF2
G.hgh4 327 E G.hgh4.17 AF2 AF2
G.hgh4 328 P G.hgh4.18 AF2 AF2
G.hgh4 329 G G.hgh4.19 AF2 AF2
G.hgh4 330 E G.hgh4.20 AF2 AF2
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure AF2
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure AF2
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure AF2
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure AF2
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 AF2 AF2
G.h4s6 354 D G.h4s6.10 Structure AF2
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure AF2
G.s6h5 368 D G.s6h5.05 Structure AF2
G.H5 369 T G.H5.01 Structure AF2
G.H5 370 E G.H5.02 Structure AF2
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 284 from structure (83.3%), 57 from model (16.7%)
Residue sidechains - 248 from structure (72.7%), 93 from model (27.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 G - AF2 AF2
N-term 3 Q - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 G - AF2 AF2
N-term 6 N - AF2 AF2
N-term 7 G - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 F - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 A - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 N - AF2 AF2
N-term 16 G - AF2 AF2
N-term 17 S - AF2 AF2
N-term 18 H - AF2 AF2
N-term 19 A - AF2 AF2
N-term 20 P - AF2 AF2
N-term 21 D - AF2 AF2
N-term 22 H - AF2 AF2
N-term 23 D - AF2 AF2
N-term 24 V - AF2 AF2
N-term 25 T - AF2 AF2
TM1 26 Q 1.25x25 AF2 AF2
TM1 27 E 1.26x26 AF2 AF2
TM1 28 R 1.27x27 AF2 AF2
TM1 29 D 1.28x28 AF2 AF2
TM1 30 E 1.29x29 AF2 AF2
TM1 31 V 1.30x30 Structure Structure
TM1 32 W 1.31x31 Structure AF2
TM1 33 V 1.32x32 Structure AF2
TM1 34 V 1.33x33 Structure AF2
TM1 35 G 1.34x34 Structure Structure
TM1 36 M 1.35x35 Structure Structure
TM1 37 G 1.36x36 Structure Structure
TM1 38 I 1.37x37 Structure Structure
TM1 39 V 1.38x38 Structure Structure
TM1 40 M 1.39x39 Structure Structure
TM1 41 S 1.40x40 Structure Structure
TM1 42 L 1.41x41 Structure AF2
TM1 43 I 1.42x42 Structure Structure
TM1 44 V 1.43x43 Structure Structure
TM1 45 L 1.44x44 Structure Structure
TM1 46 A 1.45x45 Structure Structure
TM1 47 I 1.46x46 Structure Structure
TM1 48 V 1.47x47 Structure Structure
TM1 49 F 1.48x48 Structure Structure
TM1 50 G 1.49x49 Structure Structure
TM1 51 N 1.50x50 Structure Structure
TM1 52 V 1.51x51 Structure Structure
TM1 53 L 1.52x52 Structure Structure
TM1 54 V 1.53x53 Structure Structure
TM1 55 I 1.54x54 Structure Structure
TM1 56 T 1.55x55 Structure Structure
TM1 57 A 1.56x56 Structure Structure
TM1 58 I 1.57x57 Structure Structure
TM1 59 A 1.58x58 Structure Structure
TM1 60 K 1.59x59 Structure Structure
TM1 61 F 1.60x60 Structure Structure
ICL1 62 E 12.48x48 Structure AF2
ICL1 63 R 12.49x49 Structure Structure
ICL1 64 L 12.50x50 Structure Structure
ICL1 65 Q 12.51x51 Structure Structure
TM2 66 T 2.37x37 Structure Structure
TM2 67 V 2.38x38 Structure Structure
TM2 68 T 2.39x39 Structure Structure
TM2 69 N 2.40x40 Structure Structure
TM2 70 Y 2.41x41 Structure Structure
TM2 71 F 2.42x42 Structure Structure
TM2 72 I 2.43x43 Structure Structure
TM2 73 T 2.44x44 Structure Structure
TM2 74 S 2.45x45 Structure Structure
TM2 75 L 2.46x46 Structure Structure
TM2 76 A 2.47x47 Structure Structure
TM2 77 C 2.48x48 Structure AF2
TM2 78 A 2.49x49 Structure Structure
TM2 79 D 2.50x50 Structure Structure
TM2 80 L 2.51x51 Structure Structure
TM2 81 V 2.52x52 Structure Structure
TM2 82 M 2.53x53 Structure Structure
TM2 83 G 2.54x54 Structure Structure
TM2 84 L 2.55x55 Structure Structure
TM2 85 A 2.56x551 Structure Structure
TM2 86 V 2.57x56 Structure Structure
TM2 87 V 2.58x57 Structure Structure
TM2 88 P 2.59x58 Structure Structure
TM2 89 F 2.60x59 Structure Structure
TM2 90 G 2.61x60 Structure Structure
TM2 91 A 2.62x61 Structure Structure
TM2 92 A 2.63x62 Structure Structure
TM2 93 H 2.64x63 Structure Structure
TM2 94 I 2.65x64 Structure Structure
TM2 95 L 2.66x65 Structure Structure
TM2 96 M 2.67x66 Structure AF2
TM2 97 K 2.68x67 Structure AF2
ECL1 98 M 23.49x49 Structure AF2
ECL1 99 W 23.50x50 Structure AF2
ECL1 100 T 23.51x51 Structure Structure
ECL1 101 F 23.52x52 Structure AF2
TM3 102 G 3.21x21 Structure Structure
TM3 103 N 3.22x22 Structure Structure
TM3 104 F 3.23x23 Structure AF2
TM3 105 W 3.24x24 Structure Structure
TM3 106 C 3.25x25 Structure Structure
TM3 107 E 3.26x26 Structure AF2
TM3 108 F 3.27x27 Structure Structure
TM3 109 W 3.28x28 Structure Structure
TM3 110 T 3.29x29 Structure Structure
TM3 111 S 3.30x30 Structure Structure
TM3 112 I 3.31x31 Structure Structure
TM3 113 D 3.32x32 Structure Structure
TM3 114 V 3.33x33 Structure Structure
TM3 115 L 3.34x34 Structure Structure
TM3 116 C 3.35x35 Structure Structure
TM3 117 V 3.36x36 Structure Structure
TM3 118 T 3.37x37 Structure Structure
TM3 119 A 3.38x38 Structure Structure
TM3 120 S 3.39x39 Structure Structure
TM3 121 I 3.40x40 Structure Structure
TM3 122 E 3.41x41 Structure AF2
TM3 123 T 3.42x42 Structure Structure
TM3 124 L 3.43x43 Structure Structure
TM3 125 C 3.44x44 Structure AF2
TM3 126 V 3.45x45 Structure Structure
TM3 127 I 3.46x46 Structure Structure
TM3 128 A 3.47x47 Structure Structure
TM3 129 V 3.48x48 Structure Structure
TM3 130 D 3.49x49 Structure Structure
TM3 131 R 3.50x50 Structure Structure
TM3 132 Y 3.51x51 Structure Structure
TM3 133 F 3.52x52 Structure Structure
TM3 134 A 3.53x53 Structure Structure
TM3 135 I 3.54x54 Structure Structure
TM3 136 T 3.55x55 Structure Structure
TM3 137 S 3.56x56 Structure Structure
ICL2 138 P 34.50x50 Structure Structure
ICL2 139 F 34.51x51 Structure Structure
ICL2 140 K 34.52x52 Structure Structure
ICL2 141 Y 34.53x53 Structure Structure
ICL2 142 Q 34.54x54 Structure Structure
ICL2 143 S 34.55x55 Structure Structure
ICL2 144 L 34.56x56 Structure Structure
ICL2 145 L 34.57x57 Structure Structure
TM4 146 T 4.38x38 Structure Structure
TM4 147 K 4.39x39 Structure Structure
TM4 148 N 4.40x40 Structure Structure
TM4 149 K 4.41x41 Structure Structure
TM4 150 A 4.42x42 Structure Structure
TM4 151 R 4.43x43 Structure Structure
TM4 152 V 4.44x44 Structure Structure
TM4 153 I 4.45x45 Structure Structure
TM4 154 I 4.46x46 Structure Structure
TM4 155 L 4.47x47 Structure Structure
TM4 156 M 4.48x48 Structure Structure
TM4 157 V 4.49x49 Structure Structure
TM4 158 W 4.50x50 Structure Structure
TM4 159 I 4.51x51 Structure Structure
TM4 160 V 4.52x52 Structure Structure
TM4 161 S 4.53x53 Structure Structure
TM4 162 G 4.54x54 Structure Structure
TM4 163 L 4.55x55 Structure Structure
TM4 164 T 4.56x56 Structure Structure
TM4 165 S 4.57x57 Structure Structure
TM4 166 F 4.58x58 Structure Structure
TM4 167 L 4.59x59 Structure Structure
TM4 168 P 4.60x60 Structure Structure
TM4 169 I 4.61x61 Structure Structure
TM4 170 Q 4.62x62 Structure Structure
TM4 171 M 4.63x63 Structure AF2
TM4 172 H 4.64x64 Structure Structure
ECL2 173 W - Structure AF2
ECL2 174 Y - Structure Structure
ECL2 175 R - Structure AF2
ECL2 176 A - Structure Structure
ECL2 177 T - Structure Structure
ECL2 178 H - AF2 AF2
ECL2 179 Q - Structure AF2
ECL2 180 E - Structure AF2
ECL2 181 A - Structure Structure
ECL2 182 I - Structure Structure
ECL2 183 N - Structure AF2
ECL2 184 C - Structure Structure
ECL2 185 Y - Structure Structure
ECL2 186 A - Structure Structure
ECL2 187 N - Structure AF2
ECL2 188 E - Structure AF2
ECL2 189 T - Structure Structure
ECL2 190 C - Structure Structure
ECL2 191 C 45.50x50 Structure Structure
ECL2 192 D 45.51x51 Structure AF2
ECL2 193 F 45.52x52 Structure Structure
ECL2 194 F - Structure Structure
ECL2 195 T - Structure AF2
TM5 196 N 5.35x36 Structure Structure
TM5 197 Q 5.36x37 Structure Structure
TM5 198 A 5.37x38 Structure Structure
TM5 199 Y 5.38x39 Structure Structure
TM5 200 A 5.39x40 Structure Structure
TM5 201 I 5.40x41 Structure Structure
TM5 202 A 5.41x42 Structure Structure
TM5 203 S 5.42x43 Structure Structure
TM5 204 S 5.43x44 Structure Structure
TM5 205 I 5.44x45 Structure Structure
TM5 206 V 5.45x46 Structure Structure
TM5 207 S 5.46x461 Structure Structure
TM5 208 F 5.47x47 Structure Structure
TM5 209 Y 5.48x48 Structure Structure
TM5 210 V 5.49x49 Structure Structure
TM5 211 P 5.50x50 Structure Structure
TM5 212 L 5.51x51 Structure Structure
TM5 213 V 5.52x52 Structure Structure
TM5 214 I 5.53x53 Structure Structure
TM5 215 M 5.54x54 Structure Structure
TM5 216 V 5.55x55 Structure Structure
TM5 217 F 5.56x56 Structure Structure
TM5 218 V 5.57x57 Structure Structure
TM5 219 Y 5.58x58 Structure Structure
TM5 220 S 5.59x59 Structure Structure
TM5 221 R 5.60x60 Structure Structure
TM5 222 V 5.61x61 Structure Structure
TM5 223 F 5.62x62 Structure Structure
TM5 224 Q 5.63x63 Structure Structure
TM5 225 E 5.64x64 Structure Structure
TM5 226 A 5.65x65 Structure Structure
TM5 227 K 5.66x66 Structure Structure
TM5 228 R 5.67x67 Structure Structure
TM5 229 Q 5.68x68 Structure Structure
TM5 230 L 5.69x69 Structure Structure
TM5 231 Q 5.70x70 Structure Structure
TM5 232 K 5.71x71 Structure Structure
TM5 233 I 5.72x72 Structure Structure
TM5 234 D 5.73x73 Structure Structure
TM5 235 K 5.74x74 Structure Structure
TM5 236 S 5.75x75 Structure Structure
TM5 237 E 5.76x76 Structure AF2
ICL3 238 G - Structure Structure
ICL3 239 R - Structure Structure
ICL3 240 F - AF2 AF2
ICL3 241 H - AF2 AF2
ICL3 242 V - AF2 AF2
ICL3 243 Q - AF2 AF2
ICL3 244 N - AF2 AF2
ICL3 255 G - AF2 AF2
ICL3 256 H - AF2 AF2
ICL3 257 G - AF2 AF2
ICL3 258 L - AF2 AF2
ICL3 259 R - AF2 AF2
ICL3 260 R - AF2 AF2
ICL3 261 S - AF2 AF2
TM6 262 S 6.24x24 AF2 AF2
TM6 263 K 6.25x25 AF2 AF2
TM6 264 F 6.26x26 AF2 AF2
TM6 265 C 6.27x27 Structure Structure
TM6 266 L 6.28x28 Structure Structure
TM6 267 K 6.29x29 Structure Structure
TM6 268 E 6.30x30 Structure Structure
TM6 269 H 6.31x31 Structure Structure
TM6 270 K 6.32x32 Structure Structure
TM6 271 A 6.33x33 Structure Structure
TM6 272 L 6.34x34 Structure Structure
TM6 273 K 6.35x35 Structure Structure
TM6 274 T 6.36x36 Structure Structure
TM6 275 L 6.37x37 Structure Structure
TM6 276 G 6.38x38 Structure Structure
TM6 277 I 6.39x39 Structure Structure
TM6 278 I 6.40x40 Structure Structure
TM6 279 M 6.41x41 Structure Structure
TM6 280 G 6.42x42 Structure Structure
TM6 281 T 6.43x43 Structure Structure
TM6 282 F 6.44x44 Structure Structure
TM6 283 T 6.45x45 Structure Structure
TM6 284 L 6.46x46 Structure Structure
TM6 285 C 6.47x47 Structure AF2
TM6 286 W 6.48x48 Structure Structure
TM6 287 L 6.49x49 Structure Structure
TM6 288 P 6.50x50 Structure Structure
TM6 289 F 6.51x51 Structure Structure
TM6 290 F 6.52x52 Structure Structure
TM6 291 I 6.53x53 Structure Structure
TM6 292 V 6.54x54 Structure Structure
TM6 293 N 6.55x55 Structure Structure
TM6 294 I 6.56x56 Structure Structure
TM6 295 V 6.57x57 Structure Structure
TM6 296 H 6.58x58 Structure Structure
TM6 297 V 6.59x59 Structure Structure
TM6 298 I 6.60x60 Structure Structure
TM6 299 Q 6.61x61 Structure AF2
ECL3 300 D - Structure Structure
ECL3 301 N - Structure AF2
ECL3 302 L - Structure AF2
ECL3 303 I - Structure Structure
TM7 304 R 7.31x30 Structure Structure
TM7 305 K 7.32x31 Structure AF2
TM7 306 E 7.33x32 Structure AF2
TM7 307 V 7.34x33 Structure Structure
TM7 308 Y 7.35x34 Structure Structure
TM7 309 I 7.36x35 Structure Structure
TM7 310 L 7.37x36 Structure Structure
TM7 311 L 7.38x37 Structure Structure
TM7 312 N 7.39x38 Structure Structure
TM7 313 W 7.40x39 Structure Structure
TM7 314 I 7.41x40 Structure AF2
TM7 315 G 7.42x41 Structure Structure
TM7 316 Y 7.43x42 Structure Structure
TM7 317 V 7.44x43 Structure Structure
TM7 318 N 7.45x45 Structure Structure
TM7 319 S 7.46x46 Structure Structure
TM7 320 G 7.47x47 Structure Structure
TM7 321 F 7.48x48 Structure Structure
TM7 322 N 7.49x49 Structure Structure
TM7 323 P 7.50x50 Structure Structure
TM7 324 L 7.51x51 Structure Structure
TM7 325 I 7.52x52 Structure Structure
TM7 326 Y 7.53x53 Structure Structure
TM7 327 C 7.54x54 Structure AF2
TM7 328 R 7.55x55 Structure Structure
H8 329 S 8.47x47 Structure Structure
H8 330 P 8.48x48 Structure Structure
H8 331 D 8.49x49 Structure AF2
H8 332 F 8.50x50 Structure Structure
H8 333 R 8.51x51 Structure AF2
H8 334 I 8.52x52 Structure Structure
H8 335 A 8.53x53 Structure Structure
H8 336 F 8.54x54 Structure Structure
H8 337 Q 8.55x55 Structure Structure
H8 338 E 8.56x56 Structure Structure
H8 339 L 8.57x57 Structure Structure
H8 340 L 8.58x58 Structure Structure
H8 341 C 8.59x59 AF2 AF2
C-term 342 L - AF2 AF2
C-term 343 R - AF2 AF2
C-term 344 R - AF2 AF2
C-term 345 S - AF2 AF2
C-term 346 S - AF2 AF2
C-term 347 L - AF2 AF2
C-term 348 K - AF2 AF2
C-term 349 A - AF2 AF2
C-term 350 Y - AF2 AF2
C-term 351 G - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 H 241 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 H 241 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 H 241 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 Y 141 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 139 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 139 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 139 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM6 A 271 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 271 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL3 F 240 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 F 240 - G.H4 L 346 G.H4.16
Ionic TM5 K 232 5x71 G.H5 D 381 G.H5.13
Polar TM5 E 237 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 E 237 5x76 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 E 237 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 T 274 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 222 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 222 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 139 34x51 G.S3 V 217 G.S3.01
Polar TM3 I 135 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 E 237 5x76 G.H4 L 346 G.H4.16
Van-der-waals TM5 E 237 5x76 G.H4 L 346 G.H4.16
Hydrophobic ICL3 F 240 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 F 240 - G.H4 D 343 G.H4.13
Polar ICL3 Q 243 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic ICL3 Q 243 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic ICL2 F 139 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 I 233 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 226 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 A 226 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 270 6x32 G.H5 L 394 G.H5.26
Polar TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Polar ICL2 Q 142 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 Q 142 34x54 G.S1 H 41 G.S1.02
Polar C-term Y 350 - G.H3 R 280 G.H3.16
Hydrophobic C-term Y 350 - G.H3 R 280 G.H3.16
Van-der-waals C-term Y 350 - G.H3 R 280 G.H3.16
Hydrophobic TM5 A 226 5x65 G.H5 L 388 G.H5.20
Polar TM5 Q 229 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 229 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 R 239 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 R 239 - G.hgh4 P 321 G.hgh4.11
Hydrophobic ICL2 P 138 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 229 5x68 G.H5 L 388 G.H5.20
Ionic ICL3 R 239 - G.H4 D 343 G.H4.13
Polar ICL3 R 239 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 R 239 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 R 239 - G.H4 D 343 G.H4.13
Polar TM3 A 134 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 H 387 G.H5.19
Polar ICL2 S 143 34x55 G.HN Q 35 G.HN.52
Hydrophobic ICL2 S 143 34x55 G.HN Q 35 G.HN.52
Van-der-waals ICL2 S 143 34x55 G.HN Q 35 G.HN.52
Hydrophobic TM3 I 135 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 388 G.H5.20
Ionic ICL3 R 239 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 R 239 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 R 239 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 239 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 S 143 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL3 F 240 - G.H4 R 342 G.H4.12
Aromatic ICL2 F 139 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 139 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 139 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 138 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 138 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 138 34x50 G.H5 R 380 G.H5.12
Polar TM6 T 274 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 274 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 274 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 L 275 6x37 G.H5 L 393 G.H5.25
Polar TM5 Q 229 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 Q 229 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 229 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM3 I 135 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 139 34x51 G.S3 F 219 G.S3.03
Polar TM5 S 236 5x75 G.H4 R 342 G.H4.12
Aromatic TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Polar ICL3 R 239 - G.hgh4 Y 318 G.hgh4.08
Van-der-waals ICL3 R 239 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM5 Q 229 5x68 G.H5 L 394 G.H5.26
Van-der-waals TM5 Q 229 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 135 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 233 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 K 235 5x74 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 E 225 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 139 34x51 G.H5 I 383 G.H5.15