GPR174 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IZB

RESOLUTION

3.1 Å

REFERENCE

10.1371/JOURNAL.PBIO.3002387

PUBLICATION DATE

Nov. 1, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

50 interactions (Click to see)

LIGANDS

L-serine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem ,

LYSOPHOSPHATIDIC ACID - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

lysophosphatidylserine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic ICL2 F 126 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 126 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 F 126 - G.H5 Y 391 G.H5.23
Polar H8 N 297 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 N 297 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 N 297 8x48 G.H5 E 392 G.H5.24
Polar TM2 V 55 2x40 G.H5 L 394 G.H5.26
Hydrophobic TM2 V 55 2x40 G.H5 L 394 G.H5.26
Van-der-waals TM2 V 55 2x40 G.H5 L 394 G.H5.26
Hydrophobic ICL3 L 222 - G.h4s6 D 354 G.h4s6.10
Hydrophobic H8 T 296 8x47 G.H5 L 393 G.H5.25
Hydrophobic ICL3 M 218 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 M 218 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM1 F 44 1x57 G.H5 L 393 G.H5.25
Ionic ICL3 D 214 - G.H5 R 385 G.H5.17
Van-der-waals TM5 L 212 5x65 G.H5 Q 384 G.H5.16
Van-der-waals TM6 E 224 6x29 G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL3 M 218 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 M 218 - G.S6 Y 360 G.S6.02
Ionic TM6 K 225 6x30 G.H5 D 381 G.H5.13
Polar TM6 K 225 6x30 G.H5 D 381 G.H5.13
Hydrophobic TM6 K 225 6x30 G.H5 D 381 G.H5.13
Van-der-waals TM6 K 225 6x30 G.H5 D 381 G.H5.13
Polar TM3 F 119 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 F 119 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 F 119 3x53 G.H5 H 387 G.H5.19
Polar ICL2 F 126 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 126 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 123 - G.H5 Q 384 G.H5.16
Hydrophobic ICL1 R 53 - G.H5 Y 391 G.H5.23
Van-der-waals ICL1 R 53 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 124 - G.H5 C 379 G.H5.11
Aromatic ICL2 F 124 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 124 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 124 - G.S1 H 41 G.S1.02
Hydrophobic ICL3 Q 220 - G.h4s6 T 350 G.h4s6.03
Polar TM2 I 56 2x41 G.H5 L 394 G.H5.26
Hydrophobic ICL2 H 127 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 L 212 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 212 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM2 V 55 2x40 G.H5 L 393 G.H5.25
Van-der-waals TM2 V 55 2x40 G.H5 L 393 G.H5.25
Polar ICL2 H 127 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 127 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 127 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 A 54 - G.H5 L 394 G.H5.26
Van-der-waals ICL1 A 54 - G.H5 L 394 G.H5.26
Ionic TM6 E 224 6x29 G.H5 R 389 G.H5.21
Polar TM6 E 224 6x29 G.H5 R 389 G.H5.21
Hydrophobic TM3 F 119 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM1 Y 47 1x60 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 228 6x33 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 124 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 124 - G.H5 R 380 G.H5.12
Hydrophobic TM2 F 57 2x42 G.H5 L 394 G.H5.26
Hydrophobic H8 T 296 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 T 296 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 124 - G.H5 I 383 G.H5.15
Polar ICL2 P 123 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 123 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 123 - G.H5 H 387 G.H5.19
Hydrophobic TM6 K 225 6x30 G.H5 L 388 G.H5.20
Hydrophobic TM6 K 225 6x30 G.H5 R 385 G.H5.17
Polar ICL2 D 128 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 D 128 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 C 129 - G.hns1 R 38 G.hns1.02
Polar TM1 Y 47 1x60 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 F 124 - G.S3 F 219 G.S3.03
Polar ICL3 D 221 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 D 221 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 D 221 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 L 222 - G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL2 F 124 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 123 - G.H5 I 383 G.H5.15
Hydrophobic TM2 M 58 2x43 G.H5 L 394 G.H5.26
Van-der-waals TM2 M 58 2x43 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 120 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 120 3x54 G.H5 L 388 G.H5.20
Ionic TM6 E 224 6x29 G.H5 R 385 G.H5.17
Polar TM6 E 224 6x29 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 224 6x29 G.H5 R 385 G.H5.17
Polar TM5 S 211 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 S 211 5x64 G.H5 Q 384 G.H5.16
Polar ICL3 Q 220 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 Q 220 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 Q 220 - G.h4s6 Y 358 G.h4s6.20
Polar ICL2 Q 131 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Q 131 - G.H5 Y 391 G.H5.23
Polar H8 E 298 8x49 G.H5 E 392 G.H5.24
Polar TM3 M 121 3x55 G.H5 R 380 G.H5.12
Polar ICL2 C 129 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 C 129 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 C 129 - G.HN Q 35 G.HN.52
Hydrophobic TM6 K 225 6x30 G.H5 Q 384 G.H5.16
Hydrophobic TM2 M 58 2x43 G.H5 L 393 G.H5.25
Hydrophobic ICL2 C 129 - G.HN K 34 G.HN.51
Aromatic ICL2 F 124 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 124 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 124 - G.H5 F 376 G.H5.08
Polar ICL1 R 53 - G.H5 Q 390 G.H5.22
Hydrophobic ICL1 R 53 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 R 53 - G.H5 Q 390 G.H5.22
Hydrophobic H8 E 298 8x49 G.H5 L 393 G.H5.25
Ionic ICL2 D 128 - G.hns1 R 38 G.hns1.02
Polar ICL2 D 128 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 D 128 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 D 128 - G.hns1 R 38 G.hns1.02
Ionic ICL3 D 221 - G.H5 R 385 G.H5.17
Polar ICL3 D 221 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 D 221 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 D 221 - G.H5 R 385 G.H5.17
Hydrophobic H8 F 299 8x50 G.H5 L 393 G.H5.25
Polar TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 123 - G.H5 R 380 G.H5.12
Polar TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 F 119 3x53 G.H5 L 394 G.H5.26
Van-der-waals TM3 F 119 3x53 G.H5 L 394 G.H5.26
Hydrophobic TM3 R 116 3x50 G.H5 L 394 G.H5.26
Van-der-waals TM3 R 116 3x50 G.H5 L 394 G.H5.26
Hydrophobic TM3 R 115 3x49 G.H5 L 394 G.H5.26
Van-der-waals TM3 R 115 3x49 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 112 3x46 G.H5 L 394 G.H5.26
Van-der-waals TM3 I 112 3x46 G.H5 L 394 G.H5.26