GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.4 Å

REFERENCE

PUBLICATION DATE

April 1, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Adrenomedullin - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 I 241 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 241 3x58 G.H5 L 388 G.H5.20
Van-der-waals ICL2 K 249 - G.HN Q 35 G.HN.52
Polar H8 N 388 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 388 8x47 G.H5 E 392 G.H5.24
Polar TM3 V 242 3x59 G.H5 R 380 G.H5.12
Aromatic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 241 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 341 6x45 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 341 6x45 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 246 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 246 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 F 246 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 F 246 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 K 249 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 K 249 - G.hns1 A 39 G.hns1.03
Polar TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Polar H8 G 389 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 G 389 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 G 389 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 A 244 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 A 244 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 312 5x57 G.H5 L 393 G.H5.25
Hydrophobic TM7 F 384 7x57 G.H5 Y 391 G.H5.23
Hydrophobic TM3 Y 236 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 236 3x53 G.H5 Y 391 G.H5.23
Polar TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 F 246 - G.hns1 A 39 G.hns1.03
Polar TM6 R 336 6x40 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 336 6x40 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 246 - G.S1 T 40 G.S1.01
Hydrophobic TM6 A 337 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 337 6x41 G.H5 L 393 G.H5.25
Ionic TM5 K 319 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 319 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 319 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 319 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 L 316 5x61 G.H5 L 394 G.H5.26
Aromatic ICL2 F 246 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 246 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 246 - G.S1 H 41 G.S1.02
Polar TM5 K 319 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 319 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 319 5x64 G.H5 R 385 G.H5.17
Hydrophobic ICL3 V 322 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 V 322 - G.H5 R 385 G.H5.17
Polar TM3 L 240 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 240 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 240 3x57 G.H5 H 387 G.H5.19
Van-der-waals H8 E 390 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 237 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 237 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 E 248 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 L 316 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 316 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 320 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM2 H 177 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 241 3x58 G.H5 L 393 G.H5.25
Polar ICL2 E 248 - G.HN Q 35 G.HN.52
Hydrophobic TM6 I 340 6x44 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 316 5x61 G.H5 L 393 G.H5.25
Polar TM3 I 241 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 241 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 241 3x58 G.H5 Q 384 G.H5.16