calcitonin receptor-like receptor (calrl_human)
FAMILY
Class B1 (Secretin) Peptide receptors Calcitonin receptors calcitonin receptor-like receptor
GENE
CALCRL (CGRPR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
K
|
K
|
C
|
T
|
L
|
Y
|
F
|
L
|
10 |
V
|
L
|
L
|
P
|
F
|
F
|
M
|
I
|
L
|
V
|
20 |
T
|
A
|
E
|
L
|
E
|
E
|
S
|
P
|
E
|
D
|
30 |
S
|
I
|
Q
|
L
|
G
|
V
|
T
|
R
|
N
|
K
|
40 |
I
|
M
|
T
|
A
|
Q
|
Y
|
E
|
C
|
Y
|
Q
|
50 |
K
|
I
|
M
|
Q
|
D
|
P
|
I
|
Q
|
Q
|
A
|
60 |
E
|
G
|
V
|
Y
|
C
|
N
|
R
|
T
|
W
|
D
|
70 |
G
|
W
|
L
|
C
|
W
|
N
|
D
|
V
|
A
|
A
|
80 |
G
|
T
|
E
|
S
|
M
|
Q
|
L
|
C
|
P
|
D
|
90 |
Y
|
F
|
Q
|
D
|
F
|
D
|
P
|
S
|
E
|
K
|
100 |
V
|
T
|
K
|
I
|
C
|
D
|
Q
|
D
|
G
|
N
|
110 |
W
|
F
|
R
|
H
|
P
|
A
|
S
|
N
|
R
|
T
|
120 |
W
|
T
|
N
|
Y
|
T
|
Q
|
C
|
N
|
V
|
N
|
130 |
TM1 | |||||||||
T
|
H
|
E
|
K
|
V
|
K
|
T
|
A
|
L
|
N
|
140 |
L
|
F
|
Y
|
L
|
T
|
I
|
I
|
G
|
H
|
G
|
150 |
L
|
S
|
I
|
A
|
S
|
L
|
L
|
I
|
S
|
L
|
160 |
ICL1 | |||||||||
G
|
I
|
F
|
F
|
Y
|
F
|
K
|
S
|
L
|
S
|
170 |
TM2 | |||||||||
C
|
Q
|
R
|
I
|
T
|
L
|
H
|
K
|
N
|
L
|
180 |
F
|
F
|
S
|
F
|
V
|
C
|
N
|
S
|
V
|
V
|
190 |
T
|
I
|
I
|
H
|
L
|
T
|
A
|
V
|
A
|
N
|
200 |
ECL1 | |||||||||
N
|
Q
|
A
|
L
|
V
|
A
|
T
|
N
|
P
|
V
|
210 |
TM3 | |||||||||
S
|
C
|
K
|
V
|
S
|
Q
|
F
|
I
|
H
|
L
|
220 |
Y
|
L
|
M
|
G
|
C
|
N
|
Y
|
F
|
W
|
M
|
230 |
L
|
C
|
E
|
G
|
I
|
Y
|
L
|
H
|
T
|
L
|
240 |
ICL2 | |||||||||
I
|
V
|
V
|
A
|
V
|
F
|
A
|
E
|
K
|
Q
|
250 |
TM4 | |||||||||
H
|
L
|
M
|
W
|
Y
|
Y
|
F
|
L
|
G
|
W
|
260 |
G
|
F
|
P
|
L
|
I
|
P
|
A
|
C
|
I
|
H
|
270 |
A
|
I
|
A
|
R
|
S
|
L
|
Y
|
Y
|
N
|
D
|
280 |
ECL2 | TM5 | ||||||||
N
|
C
|
W
|
I
|
S
|
S
|
D
|
T
|
H
|
L
|
290 |
L
|
Y
|
I
|
I
|
H
|
G
|
P
|
I
|
C
|
A
|
300 |
A
|
L
|
L
|
V
|
N
|
L
|
F
|
F
|
L
|
L
|
310 |
N
|
I
|
V
|
R
|
V
|
L
|
I
|
T
|
K
|
L
|
320 |
ICL3 | |||||||||
K
|
V
|
T
|
H
|
Q
|
A
|
E
|
S
|
N
|
L
|
330 |
TM6 | |||||||||
Y
|
M
|
K
|
A
|
V
|
R
|
A
|
T
|
L
|
I
|
340 |
L
|
V
|
P
|
L
|
L
|
G
|
I
|
E
|
F
|
V
|
350 |
ECL3 | |||||||||
L
|
I
|
P
|
W
|
R
|
P
|
E
|
G
|
K
|
I
|
360 |
TM7 | |||||||||
A
|
E
|
E
|
V
|
Y
|
D
|
Y
|
I
|
M
|
H
|
370 |
I
|
L
|
M
|
H
|
F
|
Q
|
G
|
L
|
L
|
V
|
380 |
H8 | |||||||||
S
|
T
|
I
|
F
|
C
|
F
|
F
|
N
|
G
|
E
|
390 |
V
|
Q
|
A
|
I
|
L
|
R
|
R
|
N
|
W
|
N
|
400 |
Q
|
Y
|
K
|
I
|
Q
|
F
|
G
|
N
|
S
|
F
|
410 |
C-term | |||||||||
S
|
N
|
S
|
E
|
A
|
L
|
R
|
S
|
A
|
S
|
420 |
Y
|
T
|
V
|
S
|
T
|
I
|
S
|
D
|
G
|
P
|
430 |
G
|
Y
|
S
|
H
|
D
|
C
|
P
|
S
|
E
|
H
|
440 |
L
|
N
|
G
|
K
|
S
|
I
|
H
|
D
|
I
|
E
|
450 |
N
|
V
|
L
|
L
|
K
|
P
|
E
|
N
|
L
|
Y
|
460 |
N
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available