calcitonin receptor-like receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6E3Y

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41586-018-0535-Y

PUBLICATION DATE

Sept. 19, 2018

3D VIEW

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LIGAND INTERACTIONS

118 interactions (Click to see)

LIGANDS

Calcitonin gene-related peptide 1 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 316 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 316 5x61 G.H5 L 388 G.H5.20
Aromatic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 319 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 319 5x64 G.H5 D 381 G.H5.13
Polar TM3 V 242 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 242 3x59 G.H5 R 380 G.H5.12
Polar TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 316 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 316 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 341 6x45 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 341 6x45 G.H5 L 393 G.H5.25
Hydrophobic ICL2 E 248 - G.hns1 A 39 G.hns1.03
Hydrophobic TM3 I 241 3x58 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 319 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 240 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 240 3x57 G.H5 H 387 G.H5.19
Polar H8 N 388 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 388 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM2 H 177 2x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 T 323 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 F 246 - G.S3 F 219 G.S3.03
Hydrophobic TM6 K 333 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 333 6x37 G.H5 L 394 G.H5.26
Polar TM3 V 242 3x59 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 246 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 246 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 316 5x61 G.H5 L 393 G.H5.25
Aromatic ICL2 F 246 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 246 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 246 - G.H5 F 376 G.H5.08
Ionic TM6 R 336 6x40 G.H5 E 392 G.H5.24
Polar TM6 R 336 6x40 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 336 6x40 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 241 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 241 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 V 245 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 245 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 246 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 V 245 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 245 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 312 5x57 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 246 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 246 - G.H5 I 383 G.H5.15
Hydrophobic TM3 L 237 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 237 3x54 G.H5 Y 391 G.H5.23
Polar TM3 I 241 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 241 3x58 G.H5 Q 384 G.H5.16
Polar TM5 K 319 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 319 5x64 G.H5 R 385 G.H5.17
Polar TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Polar H8 G 389 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 G 389 8x48 G.H5 E 392 G.H5.24
Polar TM6 R 336 6x40 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 241 3x58 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 246 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 246 - G.S3 V 217 G.S3.01
Polar ICL2 V 243 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 320 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 320 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL2 E 248 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 248 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 V 245 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 245 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 246 - G.S1 H 41 G.S1.02
Hydrophobic TM3 L 240 3x57 G.H5 Y 391 G.H5.23