Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
calrl_human 3.29x29 212 TM3 C => A N/A N/A Kuwasako K et al (2003)
calrl_human 3.42x42 225 TM3 C => A N/A N/A Kuwasako K et al (2003)
calrl_human 45.50x50 282 ECL2 C => A N/A N/A Kuwasako K et al (2003)
calrl_human 3.29x29 212 TM3 C => A 41.667↓ EC50 (Functional - cAMP accumulation) adrenomedullin Kuwasako K et al (2003) Salam W et al (2025)
calrl_human 3.42x42 225 TM3 C => A 2.581↑ EC50 (Functional - cAMP accumulation) adrenomedullin Kuwasako K et al (2003) Salam W et al (2025)
calrl_human 45.50x50 282 ECL2 C => A 13.699↓ EC50 (Functional - cAMP accumulation) adrenomedullin Kuwasako K et al (2003) Salam W et al (2025)
calrl_human 4.53x53 263 TM4 P => A 2.288↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Conner AC et al (2005) Salam W et al (2025)
calrl_human 4.53x53 263 TM4 P => A 1.38↑ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Conner AC et al (2005) Salam W et al (2025)
calrl_human 4.56x56 266 TM4 P => A 1.096↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Conner AC et al (2005) Salam W et al (2025)
calrl_human 4.56x56 266 TM4 P => A 2.138↑ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Conner AC et al (2005) Salam W et al (2025)
calrl_human 5.42x42 297 TM5 P => A 1.739↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Conner AC et al (2005) Salam W et al (2025)
calrl_human 5.42x42 297 TM5 P => A 1.122↑ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Conner AC et al (2005) Salam W et al (2025)
calrl_human 6.47x47 343 TM6 P => A 200.0↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Conner AC et al (2005) Salam W et al (2025)
calrl_human 6.47x47 343 TM6 P => A 14.085↓ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Conner AC et al (2005) Salam W et al (2025)
calrl_human 6.57x57 353 TM6 P => A 10.753↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Conner AC et al (2005) Salam W et al (2025)
calrl_human 6.57x57 353 TM6 P => A 3.39↓ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Conner AC et al (2005) Salam W et al (2025)
calrl_human 2.67x67 194 TM2 H => A Abolished effect pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 2.67x67 194 TM2 H => A 3.636↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 2.68x68 195 TM2 L => A 31.25↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 2.69x69 196 TM2 T => A 2.818↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 2.70x70 197 TM2 A => L 1.096↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 2.71x71 198 TM2 V => A 6.173↓ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 2.71x71 198 TM2 V => A 6.329↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 199 ECL1 A => L 41.667↓ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 199 ECL1 A => L 21.277↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 200 ECL1 N => A 1.513↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 201 ECL1 N => A 3.162↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 202 ECL1 Q => A 2.088↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 203 ECL1 A => L 2.754↑ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 203 ECL1 A => L 10.471↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 204 ECL1 L => A 1.122↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 204 ECL1 L => A 1.122↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 205 ECL1 V => A 2.63↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 206 ECL1 A => L 1.549↑ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 206 ECL1 A => L 8.71↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 207 ECL1 T => A 3.311↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 207 ECL1 T => A 3.311↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 208 ECL1 N => A 1.35↓ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 208 ECL1 N => A 1.318↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 209 ECL1 P => A 1.148↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 209 ECL1 P => A 1.148↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 209 ECL1 P => A 1.148↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.27x27 210 TM3 V => A 1.0 pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.27x27 210 TM3 V => A 3.09↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.27x27 210 TM3 V => A 3.09↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.28x28 211 TM3 S => A 1.288↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.28x28 211 TM3 S => A 1.011↓ EC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.29x29 212 TM3 C => A 8.547↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.29x29 212 TM3 C => A 125.0↓ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.29x29 212 TM3 C => A 8.547↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.30x30 213 TM3 K => A 5.128↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.31x31 214 TM3 V => A 1.38↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.32x32 215 TM3 S => A 1.047↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.33x33 216 TM3 Q => A 2.042↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.33x33 216 TM3 Q => A 2.042↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.33x33 216 TM3 Q => A 2.042↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.34x34 217 TM3 F => A 3.717↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.35x35 218 TM3 I => A 2.138↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.36x36 219 TM3 H => A 11.494↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.36x36 219 TM3 H => A 12.658↓ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.37x37 220 TM3 L => A 7.079↑ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.37x37 220 TM3 L => A 25.119↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.38x38 221 TM3 Y => A 5.236↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.39x39 222 TM3 L => A 8.318↑ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.39x39 222 TM3 L => A 6.31↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.40x40 223 TM3 M => A 1.148↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.40x40 223 TM3 M => A 1.148↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 3.40x40 223 TM3 M => A 1.148↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.53x53 349 TM6 F => A 1.349↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.53x53 349 TM6 F => A 1.349↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.53x53 349 TM6 F => A 1.349↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.54x54 350 TM6 V => A 1.412↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.54x54 350 TM6 V => A 1.412↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.54x54 350 TM6 V => A 1.412↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.55x55 351 TM6 L => A 1.514↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.55x55 351 TM6 L => A Abolished effect pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.56x56 352 TM6 I => A 4.673↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.56x56 352 TM6 I => A 4.673↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.56x56 352 TM6 I => A 4.673↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.57x57 353 TM6 P => A 3.39↓ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.57x57 353 TM6 P => A 5.376↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.58x58 354 TM6 W => A 1.479↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 6.58x58 354 TM6 W => A 1.818↓ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 355 ECL3 R => A 2.041↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 355 ECL3 R => A 2.041↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 355 ECL3 R => A 2.041↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 356 ECL3 P => A 2.755↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 357 ECL3 E => A 33.333↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 357 ECL3 E => A Abolished effect pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 358 ECL3 G => A 1.658↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.32x31 359 TM7 K => A 1.514↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.32x31 359 TM7 K => A 1.514↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.32x31 359 TM7 K => A 1.514↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.33x32 360 TM7 I => A 7.246↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.33x32 360 TM7 I => L 8.696↓ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.34x33 361 TM7 A => L 1.995↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.34x33 361 TM7 A => L 1.995↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.34x33 361 TM7 A => L 1.995↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.35x34 362 TM7 E => A 1.122↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.35x34 362 TM7 E => A 2.041↓ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.36x35 363 TM7 E => A 3.311↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.36x35 363 TM7 E => A 3.311↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.36x35 363 TM7 E => A 3.311↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.37x36 364 TM7 V => A 1.445↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.38x37 365 TM7 Y => A 1.349↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.38x37 365 TM7 Y => A 1.349↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.38x37 365 TM7 Y => A 1.349↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.39x38 366 TM7 D => A 1.514↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.40x39 367 TM7 Y => A 1.905↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.40x39 367 TM7 Y => A 1.905↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.40x39 367 TM7 Y => A 1.905↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.41x40 368 TM7 I => A 1.479↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.42x41 369 TM7 M => A 4.074↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.42x41 369 TM7 M => A 4.074↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.42x41 369 TM7 M => A 4.074↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.43x42 370 TM7 H => A 1.698↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.44x43 371 TM7 I => A 2.089↑ pIC50 (Binding - Radioligand competition/displacement) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.44x43 371 TM7 I => A 1.66↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.45x44 372 TM7 L => A 1.413↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.45x44 372 TM7 L => A 1.413↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 7.46x45 373 TM7 M => A 1.995↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Barwell J et al (2011) Salam W et al (2025)
calrl_human 32 N-term I => A 1.513↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 32 N-term I => A 1.38↑ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 32 N-term I => A 2.288↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 32 N-term I => A 1.023↑ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 32 N-term I => A 1.349↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Watkins HA et al (2014) Salam W et al (2025)
calrl_human 33 N-term Q => A 1.698↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 33 N-term Q => A 1.23↑ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 33 N-term Q => A 1.072↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 33 N-term Q => A 1.413↑ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 33 N-term Q => A 1.818↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Watkins HA et al (2014) Salam W et al (2025)
calrl_human 34 N-term L => A 5.128↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 34 N-term L => A 4.082↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 34 N-term L => A 2.457↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 34 N-term L => A 1.949↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 34 N-term L => A 1.288↑ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Watkins HA et al (2014) Salam W et al (2025)
calrl_human 35 N-term G => A 1.445↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 35 N-term G => A 2.041↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 35 N-term G => A 1.996↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 35 N-term G => A 3.311↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 35 N-term G => A 4.464↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Watkins HA et al (2014) Salam W et al (2025)
calrl_human 36 N-term V => A 2.137↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 36 N-term V => A 1.412↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 36 N-term V => A 2.95↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 36 N-term V => A 1.698↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 36 N-term V => A 1.779↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Watkins HA et al (2014) Salam W et al (2025)
calrl_human 37 N-term T => A 9.524↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 37 N-term T => A 4.902↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 37 N-term T => A 13.514↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 37 N-term T => A 27.027↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 37 N-term T => A 1.096↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Watkins HA et al (2014) Salam W et al (2025)
calrl_human 41 N-term I => A 7.092↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 41 N-term I => A 19.608↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 41 N-term I => A 16.949↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 41 N-term I => A Abolished effect pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 41 N-term I => A Abolished effect pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Watkins HA et al (2014) Salam W et al (2025)
calrl_human 42 N-term M => A 1.621↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 42 N-term M => A 1.381↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 42 N-term M => A 4.274↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 42 N-term M => A 2.237↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 42 N-term M => A 1.072↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Watkins HA et al (2014) Salam W et al (2025)
calrl_human 45 N-term Q => A 1.621↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 45 N-term Q => A 1.024↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 45 N-term Q => A 3.802↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 45 N-term Q => A Abolished effect pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 45 N-term Q => A 1.949↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Watkins HA et al (2014) Salam W et al (2025)
calrl_human 52 N-term I => A 2.457↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 52 N-term I => A 1.548↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 52 N-term I => A 1.202↑ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 52 N-term I => A 1.479↓ pEC50 (Functional - cAMP accumulation) adrenomedullin Watkins HA et al (2014) Salam W et al (2025)
calrl_human 52 N-term I => A 3.236↓ pEC50 (Functional - cAMP accumulation) calcitonin gene-related peptide 1 Watkins HA et al (2014) Salam W et al (2025)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K S L S ICL1ECL1 A N N Q A L V A T N P ECL1ICL2 A V F A E K Q ICL2ECL2 N D N C W I S S D ECL2ICL3 V T H Q A E S N L ICL3ECL3 R P E G ECL3N-term M E K K C T L Y F L V L L P F F M I L V T A E L E E S P E D S I Q L G V T R N K I M T A Q Y E C Y Q K I M Q D P I Q Q A E G V Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D Q D G N W F R H P A S N R T W T N Y T Q C N V N-termC-term E A L R S A S Y T V S T I S D G P G Y S H D C P S E H L N G K S I H D I E N V L L K P E N L Y N C-term N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F C Q R I T L H K N L F F S F V C N S V V T I I H L T A V V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K Y M K A V R A T L I L V P L L G I E F V L I P W K I A E E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E L R R Y K I S F S V Q A I N W N Q Q F G N N S
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L L S A I S L G H G I I T L Y F L N L A 1 K N L F F S F V C N S V V T I I H L T A 2 C L M W F Y N C G M L Y L H I F Q S V K 3 H L M W Y Y F G L W G F P L I P A C I H A 4 L F F L N V L L A A C I P G H I I Y L L H 5 L I L V P L L G I E F V L I P W 6 T S V L L G Q F H M L I H M I Y D Y V 7
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Residue Table


GPCRdb(A)
GPCRdb(B)
calcitonin receptor-like receptor
TM2
2x60 2.67x67 H194
2x61 2.68x68 L195
2x62 2.69x69 T196
2x63 2.70x70 A197
2x64 2.71x71 V198
TM3
3x23 3.27x27 V210
3x24 3.28x28 S211
3x25 3.29x29 C212
3x26 3.30x30 K213
3x27 3.31x31 V214
3x28 3.32x32 S215
3x29 3.33x33 Q216
3x30 3.34x34 F217
3x31 3.35x35 I218
3x32 3.36x36 H219
3x33 3.37x37 L220
3x34 3.38x38 Y221
3x35 3.39x39 L222
3x36 3.40x40 M223
3x38 3.42x42 C225
TM4
4x53 4.53x53 P263
4x56 4.56x56 P266
TM5
5x46 5.42x42 P297
TM6
6x42 6.47x47 P343
6x48 6.53x53 F349
6x49 6.54x54 V350
6x50 6.55x55 L351
6x51 6.56x56 I352
6x52 6.57x57 P353
6x53 6.58x58 W354
TM7
7x27 7.32x31 K359
7x28 7.33x32 I360
7x29 7.34x33 A361
7x30 7.35x34 E362
7x31 7.36x35 E363
7x32 7.37x36 V364
7x33 7.38x37 Y365
7x34 7.39x38 D366
7x35 7.40x39 Y367
7x36 7.41x40 I368
7x37 7.42x41 M369
7x38 7.43x42 H370
7x39 7.44x43 I371
7x40 7.45x44 L372
7x41 7.46x45 M373