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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[D-Tyr⁸]CYN 154806	1506	None	0	Human	Binding	pKi	=	-	5.15	-2238	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12616335
[L-Tyr⁸]CYN 154806	2375	None	0	Human	Binding	pKi	=	-	5.80	-281	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12616335
ARSENIC TRIOXIDE	197249	None	1	Rat	Binding	Kd	=	52.48	7.28	478	2	Displacement of [125I]SRIF14 from rat sst1 receptor from rat brain cortex membrane	ChEMBL	197.8	1	0	3	-2.19	O=[As][As+](=O)[O-]	https://dx.doi.org/10.1016/j.bmcl.2007.04.078
BIM 23052	642	None	0	Human	Binding	pKi	None	-	8.40	-4	9	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8769372
BIM 23052	642	None	0	Human	Binding	pKi	None	-	8.40	-4	9	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9650799
BIM 23052	642	None	0	Human	Binding	pKi	None	-	8.40	-4	9	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10598788
BIM 23268	218833	UNDEFINED	0	Human	Binding	pKi	=	18.40	7.74	-112	9	-	PDSP KiDatabase	1077.5	14	12	13	0.55	CC(O)C1NC(=O)C(CCCCN)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccccc2)NC(=O)C(N)CSSCC(C(N)=O)NC(=O)C(Cc2ccccc2)NC1=O	-
BIM 23268	218833	125I-SOMATOSTATIN	0	Human	Binding	pKi	=	582.00	6.24	-112	9	-	PDSP KiDatabase	1077.5	14	12	13	0.55	CC(O)C1NC(=O)C(CCCCN)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccccc2)NC(=O)C(N)CSSCC(C(N)=O)NC(=O)C(Cc2ccccc2)NC1=O	-
BIM 23268	218833	125I-Tyr11-somatostatin-14	0	Human	Binding	pKi	=	18.40	7.74	-112	9	-	PDSP KiDatabase	1077.5	14	12	13	0.55	CC(O)C1NC(=O)C(CCCCN)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccccc2)NC(=O)C(N)CSSCC(C(N)=O)NC(=O)C(Cc2ccccc2)NC1=O	-
BN-81,644	697	None	5	Human	Binding	Ki	=	3700.00	5.43	-5888	4	Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cells expressing cloned human SRIF receptor (sst-1) subtype	ChEMBL	426.3	8	3	2	7.02	CCCCC1(CCCC)N[C@@H](c2ncc(-c3ccccc3)[nH]2)Cc2c1[nH]c1ccccc21	https://dx.doi.org/10.1021/jm0108449
CGP 23996	891	None	0	Human	Binding	pKi	=	-	8.35	-5	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8769372
CGP 23996	891	None	0	Human	Binding	pKi	=	-	8.35	-5	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9650799
CGP 23996	891	None	0	Human	Binding	pKi	=	-	8.35	-5	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10598788
CHEMBL102892	4627	None	0	Human	Binding	Ki	=	1800.00	5.75	-1047	2	Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cells expressing cloned human SRIF receptor (sst-1) subtype	ChEMBL	396.2	3	3	2	6.07	c1ccc(-c2c[nH]c(C3Cc4c([nH]c5ccccc45)C(C4CCCCC4)N3)n2)cc1	https://dx.doi.org/10.1021/jm0108449
CHEMBL1076620	5539	None	0	Human	Binding	Kd	=	436.52	6.36	-194	2	Binding affinity to human SST1 receptor	ChEMBL	620.3	9	0	9	4.43	COC(=O)c1cc(C[C@@H](C)CN2C[C@@H](C(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)[C@H]3CCCC[C@H]3C2)cc(C(=O)OC)c1	https://dx.doi.org/10.1016/j.bmcl.2010.01.063
CHEMBL1076621	5540	None	0	Human	Binding	Kd	=	933.25	6.03	-758	2	Binding affinity to human SST1 receptor	ChEMBL	620.3	9	0	9	4.43	COC(=O)c1cc(C[C@H](C)CN2C[C@@H](C(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)[C@H]3CCCC[C@H]3C2)cc(C(=O)OC)c1	https://dx.doi.org/10.1016/j.bmcl.2010.01.063
CHEMBL1076622	5541	None	0	Human	Binding	Kd	=	1380.38	5.86	-407	7	Binding affinity to human SST1 receptor	ChEMBL	550.3	6	0	5	5.68	Cc1nc2cc(C[C@H](C)CN3C[C@@H](C(=O)N4CCN(c5ccc(F)c(F)c5)CC4)[C@H]4CCCC[C@H]4C3)ccc2o1	https://dx.doi.org/10.1016/j.bmcl.2010.01.063
CHEMBL1076622	5541	None	0	Rat	Binding	Kd	=	457.09	6.34	-134	7	Displacement of [125I]SRIF-14 from rat cortex membrane SST1 receptor	ChEMBL	550.3	6	0	5	5.68	Cc1nc2cc(C[C@H](C)CN3C[C@@H](C(=O)N4CCN(c5ccc(F)c(F)c5)CC4)[C@H]4CCCC[C@H]4C3)ccc2o1	https://dx.doi.org/10.1016/j.bmcl.2010.01.063
CHEMBL1076627	5542	None	0	Human	Binding	Kd	=	39.81	7.40	2	2	Binding affinity to human SST1 receptor	ChEMBL	549.3	6	0	5	5.19	Cc1cn2cc(C[C@H](C)CN3C[C@@H](C(=O)N4CCN(c5ccc(F)c(F)c5)CC4)[C@H]4CCCC[C@H]4C3)ccc2n1	https://dx.doi.org/10.1016/j.bmcl.2010.01.063
CHEMBL1076652	5544	None	0	Human	Binding	Kd	=	489.78	6.31	-3	2	Binding affinity to human SST1 receptor	ChEMBL	548.3	7	0	7	4.73	CC(Cc1ccc2c(c1)OCO2)CN1C[C@H](C(=O)N2CCN(c3ccc([N+](=O)[O-])cc3)CC2)C[C@@H]2CCCC[C@@H]21	https://dx.doi.org/10.1016/j.bmcl.2010.01.063

Showing 1 to 20 of 804 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

BIM 23050	641	None	0	Human	Functional	pIC50	=	-	6.40	-79	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8100350
BIM 23454	654	None	0	Human	Functional	pIC50	None	-	6.00	-31	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11897676
BIM 23627	655	None	0	Human	Functional	pIC50	=	-	5.60	-398	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11897676
CH 275	906	None	0	Human	Functional	pIC50	None	-	8.50	15	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9600011
CH 275	906	None	0	Rat	Functional	pIC50	=	-	7.30	-15	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9166718
CHEMBL4277106	166509	None	0	Human	Functional	IC50	=	6000.00	5.22	-1778	3	Antagonist activity at human SSTR1 expressed in CHO-K1 cell membranes	ChEMBL	559.2	10	2	7	6.59	CCOc1cc(CN2CC[C@H]3C(Nc4nc5ccc(C(=O)O)cc5o4)CC[C@H]32)cc(OCC)c1-c1ccc(F)cc1	https://dx.doi.org/10.1021/acsmedchemlett.8b00305
CHEMBL553655	197965	None	0	Human	Functional	EC50	=	3.90	8.41	48	3	Agonist activity at human sst1 receptor expressed in Chinese hamster CCL39 cells by luciferase reporter gene assay relative to somatostatin-14	ChEMBL	1074.4	15	10	13	1.59	CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](N(C)C(=O)c3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N[C@H](C(N)=O)[C@@H](C)O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1	https://dx.doi.org/10.1021/jm801314f
CHEMBL556949	218226	None	0	Human	Functional	EC50	=	33.00	7.48	-	1	Agonist activity at human sst1 receptor expressed in Chinese hamster CCL39 cells by luciferase reporter gene assay relative to somatostatin-14	ChEMBL	-	-	-	-	-	CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H]([C@@H](C)O)NC2=O)cc1	https://dx.doi.org/10.1021/jm801314f
CHEMBL558161	198273	None	0	Human	Functional	EC50	=	0.37	9.43	100	3	Agonist activity at human sst1 receptor expressed in Chinese hamster CCL39 cells by luciferase reporter gene assay relative to somatostatin-14	ChEMBL	1237.5	19	12	15	2.03	CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](N(C)C(=O)c3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](NC(=O)[C@H](N)Cc3ccc(O)cc3)CSSC[C@@H](C(=O)N[C@H](C(N)=O)[C@@H](C)O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1	https://dx.doi.org/10.1021/jm801314f
CHEMBL563125	218236	None	0	Human	Functional	EC50	=	0.93	9.03	-	1	Agonist activity at human sst1 receptor expressed in Chinese hamster CCL39 cells by luciferase reporter gene assay relative to somatostatin-14	ChEMBL	-	-	-	-	-	C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](c2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O	https://dx.doi.org/10.1021/jm801314f
cyclo(7-12) Des-AA^1,2,5-[Glu⁷,D-Trp⁸,IAmp⁹,m-I-Tyr¹¹,hhLys¹²]SRIF	1281	None	0	Human	Functional	pIC50	=	-	8.20	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/15658865
Des-AA^1,2,5,12,13-[D-Trp⁸]SRIF	1373	None	0	Human	Functional	pIC50	=	-	8.30	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/15658865
Des-AA^1,5-[Tyr²,D-Trp⁸,IAmp⁹]SRIF	1374	None	0	Human	Functional	pIC50	=	-	7.80	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/15658865
Des-AA⁵-[D-Trp⁸]SRIF	1375	None	0	Human	Functional	pIC50	=	-	9.00	1	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/15658864
Des-Ala^1,2,5-[D-Trp⁸,IAmp⁹]SRIF	1376	None	0	Human	Functional	pIC50	=	-	7.50	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/15658864
KE 108	2180	None	0	Human	Functional	pIC50	=	-	8.60	-3	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12450568
pasireotide	3007	None	26	Human	Functional	pIC50	=	-	8.00	-63	22	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/15477717
pasireotide	220222	None	0	Human	Functional	pIC50	=	8.00	8.10	1	5	None	Drug Central	1046.5	17	9	11	3.37	NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(c2ccccc2)NC(=O)[C@@H]2C[C@@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	-
SRIF-14	3675	None	0	Rat	Functional	pIC50	None	-	8.40	-50	13	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9166718

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Ligand source activities (1 row/activity)