Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 155513981 | 169928 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 412 | 3 | 2 | 4 | 5.3 | CC1=C(C(=O)Nc2ccccc2C)C(c2cc3ccccc3o2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4439667 | 169928 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 412 | 3 | 2 | 4 | 5.3 | CC1=C(C(=O)Nc2ccccc2C)C(c2cc3ccccc3o2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 155519653 | 170466 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 352 | 4 | 2 | 3 | 4.5 | CCC(C)C1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4447610 | 170466 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 352 | 4 | 2 | 3 | 4.5 | CCC(C)C1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 | 10.1021/acs.jmedchem.9b02036 | ||
| 155534079 | 172031 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 352 | 4 | 2 | 3 | 4.5 | CC1=C(C(=O)Nc2ccccc2C)C(CC(C)C)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4470184 | 172031 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 352 | 4 | 2 | 3 | 4.5 | CC1=C(C(=O)Nc2ccccc2C)C(CC(C)C)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 5222465 | 205283 | None | 57 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at GPR41 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR41 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay |
ChEMBL | 110 | 2 | 0 | 2 | -3.5 | CCCC(=O)[O-].[Na+] | 10.1021/acsmedchemlett.6b00025 | ||
| CHEMBL62381 | 205283 | None | 57 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at GPR41 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR41 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay |
ChEMBL | 110 | 2 | 0 | 2 | -3.5 | CCCC(=O)[O-].[Na+] | 10.1021/acsmedchemlett.6b00025 | ||
| 155518312 | 170376 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 366 | 4 | 2 | 3 | 4.8 | CC1=C(C(=O)Nc2cccc(C)c2C)C(CC(C)C)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4446176 | 170376 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 366 | 4 | 2 | 3 | 4.8 | CC1=C(C(=O)Nc2cccc(C)c2C)C(CC(C)C)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 155532033 | 171813 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 374 | 4 | 2 | 3 | 4.5 | CC1=C(C(=O)Nc2c(F)cccc2F)C(CC(C)C)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4466772 | 171813 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 374 | 4 | 2 | 3 | 4.5 | CC1=C(C(=O)Nc2c(F)cccc2F)C(CC(C)C)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 155521449 | 170657 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 358 | 4 | 2 | 3 | 4.6 | CCCC1C(C(=O)Nc2cccc(Cl)c2)=C(C)NC2=C1C(=O)CCC2 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4450056 | 170657 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 358 | 4 | 2 | 3 | 4.6 | CCCC1C(C(=O)Nc2cccc(Cl)c2)=C(C)NC2=C1C(=O)CCC2 | 10.1021/acs.jmedchem.9b02036 | ||
| 1032 | 3185 | None | 50 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 8 | 2 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.9b02036 | ||
| 1062 | 3185 | None | 50 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 8 | 2 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL14021 | 3185 | None | 50 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 8 | 2 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.9b02036 | ||
| DB03766 | 3185 | None | 50 | Human | Functional | pEC50 | = | 5.0 | 5.0 | 8 | 2 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.9b02036 | ||
| 651809 | 170627 | None | 1 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 376 | 3 | 2 | 4 | 4.5 | CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C)o2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4449702 | 170627 | None | 1 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 376 | 3 | 2 | 4 | 4.5 | CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C)o2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 155538299 | 172505 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 388 | 5 | 2 | 4 | 4.6 | CCCC1C(C(=O)Nc2cc(OC)ccc2Cl)=C(C)NC2=C1C(=O)CCC2 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4476587 | 172505 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 388 | 5 | 2 | 4 | 4.6 | CCCC1C(C(=O)Nc2cc(OC)ccc2Cl)=C(C)NC2=C1C(=O)CCC2 | 10.1021/acs.jmedchem.9b02036 | ||
| 155535425 | 172191 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 444 | 5 | 2 | 5 | 4.7 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(CCn2cccn2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4472390 | 172191 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 444 | 5 | 2 | 5 | 4.7 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(CCn2cccn2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 1032 | 3185 | None | 50 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 8 | 2 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.9b02036 | ||
| 1062 | 3185 | None | 50 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 8 | 2 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL14021 | 3185 | None | 50 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 8 | 2 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.9b02036 | ||
| DB03766 | 3185 | None | 50 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 8 | 2 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.9b02036 | ||
| 1058 | 254 | None | 52 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -3 | 2 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 60 | 0 | 1 | 1 | 0.1 | CC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| 176 | 254 | None | 52 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -3 | 2 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 60 | 0 | 1 | 1 | 0.1 | CC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| 21980959 | 254 | None | 52 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -3 | 2 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 60 | 0 | 1 | 1 | 0.1 | CC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| 4211 | 254 | None | 52 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -3 | 2 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 60 | 0 | 1 | 1 | 0.1 | CC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| CHEMBL539 | 254 | None | 52 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -3 | 2 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 60 | 0 | 1 | 1 | 0.1 | CC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| DB03166 | 254 | None | 52 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -3 | 2 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 60 | 0 | 1 | 1 | 0.1 | CC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| 1059 | 750 | None | 54 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 7 | 3 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 88 | 2 | 1 | 1 | 0.9 | CCCC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| 264 | 750 | None | 54 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 7 | 3 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 88 | 2 | 1 | 1 | 0.9 | CCCC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| CHEMBL14227 | 750 | None | 54 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 7 | 3 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 88 | 2 | 1 | 1 | 0.9 | CCCC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| DB03568 | 750 | None | 54 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 7 | 3 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 88 | 2 | 1 | 1 | 0.9 | CCCC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| 1032 | 3185 | None | 50 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 8 | 2 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| 1062 | 3185 | None | 50 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 8 | 2 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| CHEMBL14021 | 3185 | None | 50 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 8 | 2 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| DB03766 | 3185 | None | 50 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 8 | 2 | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method |
ChEMBL | 74 | 1 | 1 | 1 | 0.5 | CCC(=O)O | 10.1021/acs.jmedchem.7b00244 | ||
| 155526048 | 171192 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 338 | 4 | 2 | 3 | 4.2 | CCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4457531 | 171192 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 338 | 4 | 2 | 3 | 4.2 | CCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 | 10.1021/acs.jmedchem.9b02036 | ||
| 3142523 | 175273 | None | 4 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay |
ChEMBL | 378 | 3 | 2 | 4 | 4.7 | CC1=C(C(=O)Nc2ccccc2C)C(c2cccs2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4570341 | 175273 | None | 4 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay |
ChEMBL | 378 | 3 | 2 | 4 | 4.7 | CC1=C(C(=O)Nc2ccccc2C)C(c2cccs2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 129743659 | 175649 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 372 | 3 | 2 | 3 | 4.6 | CC1=C(C(=O)Nc2ccccc2C)C(c2ccccc2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4578663 | 175649 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 372 | 3 | 2 | 3 | 4.6 | CC1=C(C(=O)Nc2ccccc2C)C(c2ccccc2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 91885415 | 175006 | None | 32 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 3 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 416 | 3 | 2 | 4 | 5.2 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4564389 | 175006 | None | 32 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 3 | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay |
ChEMBL | 416 | 3 | 2 | 4 | 5.2 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
Showing 1 to 50 of 280 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 23681741 | 146975 | None | 9 | Rat | Binding | pEC50 | = | 4 | 4.0 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 168 | 5 | 0 | 2 | -2.3 | CCCCCCC(=O)[O-].[K+] | nan | ||
| CHEMBL3925414 | 146975 | None | 9 | Rat | Binding | pEC50 | = | 4 | 4.0 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 168 | 5 | 0 | 2 | -2.3 | CCCCCCC(=O)[O-].[K+] | nan | ||
| 155546001 | 173609 | None | 0 | Mouse | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor |
ChEMBL | 418 | 3 | 2 | 3 | 5.6 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CCCC2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4530642 | 173609 | None | 0 | Mouse | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor |
ChEMBL | 418 | 3 | 2 | 3 | 5.6 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CCCC2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 91885415 | 175006 | None | 32 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor |
ChEMBL | 416 | 3 | 2 | 4 | 5.2 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4564389 | 175006 | None | 32 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor |
ChEMBL | 416 | 3 | 2 | 4 | 5.2 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 11646235 | 1637 | None | 18 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor |
ChEMBL | 362 | 3 | 2 | 4 | 4.2 | CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 | 10.1021/acs.jmedchem.9b02036 | ||
| 12859 | 1637 | None | 18 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor |
ChEMBL | 362 | 3 | 2 | 4 | 4.2 | CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4448591 | 1637 | None | 18 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor |
ChEMBL | 362 | 3 | 2 | 4 | 4.2 | CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 | 10.1021/acs.jmedchem.9b02036 | ||
| 53322689 | 58077 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 224 | 1 | 2 | 5 | 0.7 | CCc1cc(=O)oc2nc(S)[nH]c(=O)c12 | 10.1039/d2md00076h | ||
| CHEMBL1672755 | 58077 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 224 | 1 | 2 | 5 | 0.7 | CCc1cc(=O)oc2nc(S)[nH]c(=O)c12 | 10.1039/d2md00076h | ||
| 15605571 | 75261 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 236 | 3 | 2 | 4 | 0.5 | CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12 | 10.1039/d2md00076h | ||
| CHEMBL2036813 | 75261 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 236 | 3 | 2 | 4 | 0.5 | CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12 | 10.1039/d2md00076h | ||
| 171343909 | 193728 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 252 | 3 | 2 | 4 | 1.9 | CCCCc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12 | 10.1039/d2md00076h | ||
| CHEMBL5270112 | 193728 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 252 | 3 | 2 | 4 | 1.9 | CCCCc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12 | 10.1039/d2md00076h | ||
| 171356818 | 193981 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 286 | 4 | 2 | 4 | 2.1 | O=c1cc(CCCCCl)c2c(=O)[nH]c(=S)[nH]c2o1 | 10.1039/d2md00076h | ||
| CHEMBL5275861 | 193981 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 286 | 4 | 2 | 4 | 2.1 | O=c1cc(CCCCCl)c2c(=O)[nH]c(=S)[nH]c2o1 | 10.1039/d2md00076h | ||
| 171357332 | 194030 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 238 | 2 | 2 | 4 | 1.5 | CCCc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12 | 10.1039/d2md00076h | ||
| CHEMBL5277000 | 194030 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 238 | 2 | 2 | 4 | 1.5 | CCCc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12 | 10.1039/d2md00076h | ||
| 766926 | 194224 | None | 11 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 210 | 0 | 2 | 4 | 0.8 | Cc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12 | 10.1039/d2md00076h | ||
| CHEMBL5281556 | 194224 | None | 11 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 210 | 0 | 2 | 4 | 0.8 | Cc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12 | 10.1039/d2md00076h | ||
| 171346683 | 194381 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 270 | 4 | 2 | 4 | 0.7 | O=c1[nH]c(=O)c2c(CCCCCl)cc(=O)oc2[nH]1 | 10.1039/d2md00076h | ||
| CHEMBL5284951 | 194381 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay |
ChEMBL | 270 | 4 | 2 | 4 | 0.7 | O=c1[nH]c(=O)c2c(CCCCCl)cc(=O)oc2[nH]1 | 10.1039/d2md00076h | ||
| 23668516 | 107600 | None | 10 | Rat | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 140 | 3 | 0 | 2 | -3.1 | CCCCC(=O)[O-].[K+] | nan | ||
| CHEMBL3188068 | 107600 | None | 10 | Rat | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 140 | 3 | 0 | 2 | -3.1 | CCCCC(=O)[O-].[K+] | nan | ||
| 1060 | 2089 | None | 44 | Rat | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 88 | 1 | 1 | 1 | 0.7 | CC(C(=O)O)C | nan | ||
| 6590 | 2089 | None | 44 | Rat | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 88 | 1 | 1 | 1 | 0.7 | CC(C(=O)O)C | nan | ||
| CHEMBL108778 | 2089 | None | 44 | Rat | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 88 | 1 | 1 | 1 | 0.7 | CC(C(=O)O)C | nan | ||
| DB02531 | 2089 | None | 44 | Rat | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 88 | 1 | 1 | 1 | 0.7 | CC(C(=O)O)C | nan | ||
| 61138 | 107552 | None | 63 | Rat | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 100 | 3 | 1 | 1 | 1.0 | C=CCCC(=O)O | nan | ||
| CHEMBL3185583 | 107552 | None | 63 | Rat | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 100 | 3 | 1 | 1 | 1.0 | C=CCCC(=O)O | nan | ||
| 23670380 | 145418 | None | 9 | Rat | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 154 | 4 | 0 | 2 | -2.7 | CCCCCC(=O)[O-].[K+] | nan | ||
| CHEMBL3913375 | 145418 | None | 9 | Rat | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 154 | 4 | 0 | 2 | -2.7 | CCCCCC(=O)[O-].[K+] | nan | ||
| 11646235 | 1637 | None | 18 | Mouse | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor |
ChEMBL | 362 | 3 | 2 | 4 | 4.2 | CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 | 10.1021/acs.jmedchem.9b02036 | ||
| 12859 | 1637 | None | 18 | Mouse | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor |
ChEMBL | 362 | 3 | 2 | 4 | 4.2 | CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4448591 | 1637 | None | 18 | Mouse | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor |
ChEMBL | 362 | 3 | 2 | 4 | 4.2 | CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 | 10.1021/acs.jmedchem.9b02036 | ||
| 155546001 | 173609 | None | 0 | Rat | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor |
ChEMBL | 418 | 3 | 2 | 3 | 5.6 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CCCC2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4530642 | 173609 | None | 0 | Rat | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor |
ChEMBL | 418 | 3 | 2 | 3 | 5.6 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CCCC2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 91885415 | 175006 | None | 32 | Rat | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor |
ChEMBL | 416 | 3 | 2 | 4 | 5.2 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| CHEMBL4564389 | 175006 | None | 32 | Rat | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor |
ChEMBL | 416 | 3 | 2 | 4 | 5.2 | CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 | 10.1021/acs.jmedchem.9b02036 | ||
| 2723816 | 188442 | None | 49 | Rat | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 96 | 1 | 0 | 2 | -3.9 | CCC(=O)[O-].[Na+] | nan | ||
| CHEMBL500826 | 188442 | None | 49 | Rat | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 96 | 1 | 0 | 2 | -3.9 | CCC(=O)[O-].[Na+] | nan | ||
| 23677461 | 142569 | None | 7 | Rat | Binding | pEC50 | = | 4.3 | 4.3 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 126 | 2 | 0 | 2 | -3.5 | CCCC(=O)[O-].[K+] | nan | ||
| CHEMBL3890404 | 142569 | None | 7 | Rat | Binding | pEC50 | = | 4.3 | 4.3 | - | 0 | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay |
ChEMBL | 126 | 2 | 0 | 2 | -3.5 | CCCC(=O)[O-].[K+] | nan | ||
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