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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

AS2717638	484	None	23	Human	Binding	IC50	=	38.00	7.42	-	1	Antagonist activity at human LPA5 receptor assessed as inhibition of LPS-induced cAMP accumulation incubated for 20 mins	ChEMBL	447.2	4	0	7	4.08	COc1cc2c(C(=O)N3CCCCC3)cn(-c3noc4ccc(C)cc34)c(=O)c2cc1OC	https://dx.doi.org/10.1016/j.ejmech.2021.113574
CHEMBL1351302	25583	None	2	Rat	Binding	IC50	=	1800.00	5.75	-	1	Antagonist activity at rat LPA5 receptor expressed in CHO cells assessed as inhibition of LPA-induced cAMP accumulation after 30 mins by Lance Ultra assay	ChEMBL	450.2	6	0	6	4.42	CCOc1ccc(-n2cc(C(=O)N3CCCCCC3)c3cc(OC)c(OC)cc3c2=O)cc1	https://dx.doi.org/10.1016/j.bmc.2017.11.038
CHEMBL153043	45745	None	0	Human	Binding	EC50	=	8.20	8.09	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL153043	45745	None	0	Human	Binding	EC50	=	8.13	8.09	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2017139	73546	None	0	Human	Binding	EC50	=	6.30	8.20	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.85	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2017139	73546	None	0	Human	Binding	EC50	=	6.31	8.20	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.85	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335047	87558	None	0	Human	Binding	EC50	=	3.40	8.47	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOC[C@@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335047	87558	None	0	Human	Binding	EC50	=	3.39	8.47	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOC[C@@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335048	87559	None	0	Human	Binding	EC50	=	6.10	8.21	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOC[C@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335048	87559	None	0	Human	Binding	EC50	=	6.17	8.21	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOC[C@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335052	87560	None	0	Human	Binding	EC50	=	0.83	9.08	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOCC(COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335052	87560	None	0	Human	Binding	EC50	=	0.83	9.08	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOCC(COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2364959	89093	None	0	Human	Binding	EC50	=	1.81	8.74	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2364959	89093	None	0	Human	Binding	EC50	=	1.82	8.74	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2365070	89102	None	0	Human	Binding	EC50	=	0.26	9.59	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	426.3	21	2	4	5.72	CCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2365070	89102	None	0	Human	Binding	EC50	=	0.26	9.59	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	426.3	21	2	4	5.72	CCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2365071	89103	None	0	Human	Binding	EC50	=	3.00	8.52	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	440.3	22	2	4	6.12	CCCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2365071	89103	None	0	Human	Binding	EC50	=	3.02	8.52	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	440.3	22	2	4	6.12	CCCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL357053	121145	None	0	Human	Binding	EC50	=	5.10	8.29	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL357053	121145	None	0	Human	Binding	EC50	=	5.01	8.30	-	6	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002

Showing 1 to 20 of 36 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)