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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[Ac-His¹]PACAP-27	257	None	0	Human	Binding	IC50	=	12.00	7.92	-	4	Displacement of [125I]PACAP27 from human VPAC1 receptor expressed in CHO cells	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm0609059
[Ala^11,22,28]VIP	328	None	0	Human	Binding	pKi	=	-	8.10	316	3	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10801840
[Arg¹⁶]chicken secretin	468	None	0	Human	Binding	pIC50	=	-	7.20	-	7	Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9437714
[Arg¹⁶]chicken secretin	468	None	0	Rat	Binding	pIC50	=	-	9.00	-	7	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9437714
[Lys¹⁵,Arg¹⁶,Leu²⁷]VIP-(1-7)/GRF-(8-27)-NH₂	2436	None	0	Human	Binding	pIC50	=	-	9.00	-	5	Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9437714
[Lys¹⁵,Arg¹⁶,Leu²⁷]VIP-(1-7)/GRF-(8-27)-NH₂	2436	None	0	Human	Binding	pIC50	=	-	7.70	-	5	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11931347
[Lys¹⁵,Arg¹⁶,Leu²⁷]VIP-(1-7)/GRF-(8-27)-NH₂	2436	None	0	Rat	Binding	pIC50	=	-	8.70	-	5	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9437714
BAY 55-9837	583	None	0	Human	Binding	pIC50	=	-	5.10	-	3	inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11978642
CHEMBL1893324	211519	None	20	Human	Binding	IC50	=	0.12	9.92	-	3	Binding affinity to human VPAC1 receptor by radioligand displacement assay	ChEMBL	-	-	-	-	-	CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.bmc.2013.03.016
CHEMBL1893324	211519	None	20	Human	Binding	Ki	=	0.07	10.17	-	3	Binding affinity to human VPAC1 receptor by radioligand displacement assay	ChEMBL	-	-	-	-	-	CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2013.01.044
CHEMBL1893324	211519	None	20	Human	Binding	IC50	=	0.12	9.92	-	3	Binding affinity to human VPAC1 receptor by radioligand displacement assay	ChEMBL	-	-	-	-	-	CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2013.01.044
CHEMBL1893324	211519	None	20	Human	Binding	IC50	=	0.11	9.96	-	3	Displacement of [125I]VIP from human recombinant VIP1 receptor expressed in CHO cells	ChEMBL	-	-	-	-	-	CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.bmc.2016.03.006
CHEMBL3736134	136572	None	0	Human	Binding	IC50	=	9.33	8.03	-	3	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3263.7	105	48	45	-10.62	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	https://dx.doi.org/10.1016/j.ejmech.2015.09.017
CHEMBL3736134	136572	None	0	Human	Binding	IC50	=	9.00	8.05	-	3	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3263.7	105	48	45	-10.62	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	https://dx.doi.org/10.1016/j.ejmech.2015.09.017
CHEMBL3736230	136590	None	0	Human	Binding	IC50	=	11.48	7.94	-	3	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3245.7	105	48	45	-10.76	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	https://dx.doi.org/10.1016/j.ejmech.2015.09.017
CHEMBL3736230	136590	None	0	Human	Binding	IC50	=	12.00	7.92	-	3	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3245.7	105	48	45	-10.76	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	https://dx.doi.org/10.1016/j.ejmech.2015.09.017
CHEMBL3884667	214877	None	0	Human	Binding	IC50	=	0.11	9.96	-	1	Displacement of [125I]VIP from human recombinant VPAC1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	-	-	-	-	-	CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.bmc.2016.11.014
CHEMBL4128926	161661	None	0	Human	Binding	IC50	=	0.47	9.33	-	38	Displacement of [125I]VIP from human recombinant VPAC1 receptor after 60 mins by scintillation counting analysis	ChEMBL	583.2	8	3	6	5.76	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	https://dx.doi.org/10.1016/j.bmcl.2018.03.093
CHEMBL4296687	216002	None	0	Human	Binding	IC50	=	4.90	8.31	-	1	Inhibition of human VIP1 receptor	ChEMBL	-	-	-	-	-	CC[C@@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)O	https://dx.doi.org/10.1021/jm701575k
CHEMBL507480	216823	None	0	Human	Binding	IC50	=	14.13	7.85	-	3	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	-	-	-	-	-	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	https://dx.doi.org/10.1016/j.ejmech.2015.09.017

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[Ac-His¹]PACAP-27	257	None	0	Human	Functional	EC50	=	0.60	9.22	-4	4	Activity at human VPAC1 receptor in CHO cells by measuring cAMP accumulation	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm0609059
[Ala^11,22,28]VIP	328	None	0	Human	Functional	pEC50	=	-	10.20	4168	3	cyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/16930633
[Ala^11,22,28]VIP	328	None	0	Human	Functional	pEC50	=	-	7.60	4168	3	calcium influx in CHO cells stably expressing recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/16930633
[Ala^11,22,28]VIP	328	None	0	Human	Functional	pEC50	=	-	9.40	4168	3	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10801840
[Lys¹⁵,Arg¹⁶,Leu²⁷]VIP-(1-7)/GRF-(8-27)-NH₂	2436	None	0	Human	Functional	pEC50	=	-	8.30	-2	5	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11931347
BAY 55-9837	583	None	0	Human	Functional	pEC50	=	-	7.00	-177	3	cyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11978642
cefotiam	220189	None	0	Human	Functional	pIC50	=	4.47	8.35	-	1	None	Drug Central	525.1	10	3	13	-0.65	CN(C)CCn1nnnc1SCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)Cc3csc(N)n3)[C@H]2SC1	-
CHEMBL1412798	32618	None	28	Rat	Functional	IC50	=	13000.00	4.89	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	220.1	1	1	3	2.46	CC(=O)Nc1sc2c(c1C#N)CCCC2	https://dx.doi.org/10.1016/j.bmcl.2012.01.082
CHEMBL1632048	56451	None	7	Rat	Functional	IC50	=	3400.00	5.47	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	248.1	2	1	3	3.09	CC(C)C(=O)Nc1sc2c(c1C#N)CCCC2	https://dx.doi.org/10.1016/j.bmcl.2012.01.082
CHEMBL1893324	211519	None	20	Human	Functional	EC50	=	0.02	10.70	1	3	Agonist activity at VPAC1 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	-	-	-	-	-	CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/acs.jmedchem.0c01396
CHEMBL1956259	71217	None	0	Rat	Functional	IC50	=	3200.00	5.50	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	358.2	4	1	1	6.93	CC(C)c1cc(C(C)(C)C)cc(-c2ccccc2-c2ccccc2)c1CO	https://dx.doi.org/10.1016/j.bmcl.2012.01.082
CHEMBL1956412	71223	None	0	Rat	Functional	IC50	=	200.00	6.70	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	312.2	4	1	2	5.28	COc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1	https://dx.doi.org/10.1016/j.bmcl.2012.01.082
CHEMBL1956413	71224	None	0	Rat	Functional	IC50	=	170.00	6.77	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	328.2	4	1	2	5.99	CSc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1	https://dx.doi.org/10.1016/j.bmcl.2012.01.082
CHEMBL1956414	71225	None	0	Rat	Functional	IC50	=	1300.00	5.89	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	312.2	4	1	2	5.28	COc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1	https://dx.doi.org/10.1016/j.bmcl.2012.01.082
CHEMBL1956415	71226	None	0	Rat	Functional	IC50	=	820.00	6.09	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	312.2	4	1	2	5.28	COc1ccccc1-c1cc(C(C)(C)C)cc(C(C)C)c1CO	https://dx.doi.org/10.1016/j.bmcl.2012.01.082
CHEMBL1956416	71227	None	0	Rat	Functional	IC50	=	740.00	6.13	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	300.2	3	1	1	5.41	CC(C)c1cc(C(C)(C)C)cc(-c2ccc(F)cc2)c1CO	https://dx.doi.org/10.1016/j.bmcl.2012.01.082
CHEMBL1956417	71228	None	0	Rat	Functional	IC50	=	680.00	6.17	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	358.2	4	1	1	6.93	CC(C)c1cc(C(C)(C)C)cc(-c2ccc(-c3ccccc3)cc2)c1CO	https://dx.doi.org/10.1016/j.bmcl.2012.01.082
CHEMBL1956418	71229	None	0	Rat	Functional	IC50	=	390.00	6.41	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	282.2	3	1	1	5.27	CC(C)c1cc(C(C)(C)C)cc(-c2ccccc2)c1CO	https://dx.doi.org/10.1016/j.bmcl.2012.01.082
CHEMBL1956419	71230	None	0	Rat	Functional	IC50	=	310.00	6.51	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	325.2	4	1	2	5.33	CC(C)c1cc(C(C)(C)C)cc(-c2cccc(N(C)C)c2)c1CO	https://dx.doi.org/10.1016/j.bmcl.2012.01.082
CHEMBL1956420	71231	None	0	Rat	Functional	IC50	=	300.00	6.52	-	1	Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay	ChEMBL	296.2	3	1	1	5.58	Cc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1	https://dx.doi.org/10.1016/j.bmcl.2012.01.082

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Ligand source activities (1 row/activity)