Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| CHEMBL3980643 | 219293 | 0 | None | 6 | 2 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)[C@@H](C)CC | 10.1016/j.ejmech.2016.06.006 | ||||
| 5311032 | 67020 | 33 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/j.ejmech.2016.06.006 | ||
| CHEMBL1515091 | 67020 | 33 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/j.ejmech.2016.06.006 | ||
| CHEMBL1741040 | 67020 | 33 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/j.ejmech.2016.06.006 | ||
| 10187997 | 116749 | 0 | None | -4 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL323464 | 116749 | 0 | None | -4 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL284250 | 217639 | 0 | None | 1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1016/0960-894X(95)00237-N | ||||
| 10603409 | 117381 | 0 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | ||
| CHEMBL325581 | 117381 | 0 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | ||
| 10210629 | 15536 | 0 | None | -7 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL109644 | 15536 | 0 | None | -7 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL3143473 | 218113 | 0 | None | 1071 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | None | None | None | CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00084-7 | ||||
| CHEMBL3305972 | 218113 | 0 | None | 1071 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | None | None | None | CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00084-7 | ||||
| 9916235 | 16125 | 1 | None | -4 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL111277 | 16125 | 1 | None | -4 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| 10651488 | 170158 | 0 | None | -1 | 4 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | ||
| CHEMBL419367 | 170158 | 0 | None | -1 | 4 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | ||
| 11318978 | 174682 | 0 | None | -7 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 560 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL431286 | 174682 | 0 | None | -7 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 560 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL4533479 | 220765 | 1 | None | 1 | 2 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | None | None | None | CCCOc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 | 10.6019/CHEMBL4507261 | ||||
| 11387205 | 118338 | 0 | None | 1 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 544 | 8 | 2 | 7 | 4.5 | COc1ccc(CN2C(=O)CN[C@](C3CCCCC3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL328073 | 118338 | 0 | None | 1 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 544 | 8 | 2 | 7 | 4.5 | COc1ccc(CN2C(=O)CN[C@](C3CCCCC3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 10298354 | 118783 | 0 | None | -15 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 462 | 7 | 3 | 7 | 1.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCO)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL328878 | 118783 | 0 | None | -15 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 462 | 7 | 3 | 7 | 1.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCO)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 10187313 | 114221 | 0 | None | -18 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL318247 | 114221 | 0 | None | -18 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11169125 | 214338 | 0 | None | -5 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 574 | 7 | 2 | 4 | 6.5 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL94802 | 214338 | 0 | None | -5 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 574 | 7 | 2 | 4 | 6.5 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| 10303258 | 168654 | 0 | None | -3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 564 | 10 | 2 | 6 | 5.3 | CCCCc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL415010 | 168654 | 0 | None | -3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 564 | 10 | 2 | 6 | 5.3 | CCCCc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 9957883 | 105433 | 0 | None | -25 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL27732 | 105433 | 0 | None | -25 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| 9890440 | 15026 | 0 | None | -301 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 460 | 6 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 | 10.1021/jm00008a002 | ||
| CHEMBL10924 | 15026 | 0 | None | -301 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 460 | 6 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 | 10.1021/jm00008a002 | ||
| 11753582 | 214367 | 0 | None | -4 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 586 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Br)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL94962 | 214367 | 0 | None | -4 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 586 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Br)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 3951 | 7179 | 86 | None | -47 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1021/jm031115r | ||
| 4337 | 7179 | 86 | None | -47 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1021/jm031115r | ||
| 6918493 | 7179 | 86 | None | -47 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1021/jm031115r | ||
| CHEMBL1111 | 7179 | 86 | None | -47 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1021/jm031115r | ||
| DB06403 | 7179 | 86 | None | -47 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1021/jm031115r | ||
| 11753090 | 112980 | 0 | None | -7 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Cl)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL313870 | 112980 | 0 | None | -7 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Cl)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11398658 | 214378 | 0 | None | -1 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)cc(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL95017 | 214378 | 0 | None | -1 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)cc(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 10120430 | 214299 | 0 | None | -5 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)ccc(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL94580 | 214299 | 0 | None | -5 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)ccc(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11330923 | 214601 | 0 | None | 1 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 606 | 10 | 2 | 6 | 6.3 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(C)cc(C)cc3C)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL96303 | 214601 | 0 | None | 1 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 606 | 10 | 2 | 6 | 6.3 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(C)cc(C)cc3C)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL96822 | 222699 | 0 | None | 1 | 2 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NS(C)(=O)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 11238540 | 214304 | 0 | None | -11 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 576 | 8 | 2 | 5 | 5.9 | COc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL94602 | 214304 | 0 | None | -11 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 576 | 8 | 2 | 5 | 5.9 | COc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| 10166139 | 170123 | 0 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 550 | 7 | 2 | 6 | 4.9 | Cc1cc(C)c(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c(C)c1 | 10.1021/jm031115r | ||
| CHEMBL419136 | 170123 | 0 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 550 | 7 | 2 | 6 | 4.9 | Cc1cc(C)c(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c(C)c1 | 10.1021/jm031115r | ||
| 11376627 | 114409 | 0 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(C(F)(F)F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL319007 | 114409 | 0 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(C(F)(F)F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11386977 | 214326 | 0 | None | -1 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 528 | 8 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCC3CCCCC3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL94752 | 214326 | 0 | None | -1 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 528 | 8 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCC3CCCCC3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 9955200 | 16104 | 0 | None | -380 | 3 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | ||
| CHEMBL11115 | 16104 | 0 | None | -380 | 3 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | ||
| 11318409 | 214234 | 0 | None | -3 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1cccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL94212 | 214234 | 0 | None | -3 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1cccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL413825 | 219866 | 0 | None | 4 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(95)00084-7 | ||||
| 10230737 | 119097 | 0 | None | -16 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL329251 | 119097 | 0 | None | -16 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 18995992 | 106614 | 0 | None | -3 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL28563 | 106614 | 0 | None | -3 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| 18995991 | 107076 | 0 | None | -9 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 537 | 8 | 1 | 10 | 5.0 | COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL28920 | 107076 | 0 | None | -9 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 537 | 8 | 1 | 10 | 5.0 | COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC | 10.1016/0960-894X(96)00232-6 | ||
| 10342643 | 11929 | 0 | None | -144 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm00008a002 | ||
| CHEMBL10588 | 11929 | 0 | None | -144 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm00008a002 | ||
| 11752174 | 179504 | 0 | None | -4 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 489 | 8 | 2 | 7 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN(C)C)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL450628 | 179504 | 0 | None | -4 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 489 | 8 | 2 | 7 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN(C)C)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11410074 | 214569 | 0 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 536 | 9 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96114 | 214569 | 0 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 536 | 9 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11421392 | 214164 | 0 | None | -5 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL93820 | 214164 | 0 | None | -5 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11387315 | 214213 | 0 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 552 | 8 | 2 | 7 | 4.3 | COc1ccc(CN2C(=O)CN[C@](c3ccc(C)cc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL94091 | 214213 | 0 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 552 | 8 | 2 | 7 | 4.3 | COc1ccc(CN2C(=O)CN[C@](c3ccc(C)cc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11397857 | 214570 | 0 | None | -6 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 496 | 7 | 2 | 6 | 3.7 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccc(Cl)cc32)c1 | 10.1021/jm031115r | ||
| CHEMBL96125 | 214570 | 0 | None | -6 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 496 | 7 | 2 | 6 | 3.7 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccc(Cl)cc32)c1 | 10.1021/jm031115r | ||
| 10224745 | 119467 | 0 | None | -15 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 432 | 5 | 2 | 6 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL330425 | 119467 | 0 | None | -15 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 432 | 5 | 2 | 6 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11226740 | 214681 | 0 | None | -9 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 558 | 7 | 2 | 4 | 6.0 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL96704 | 214681 | 0 | None | -9 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 558 | 7 | 2 | 4 | 6.0 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL328942 | 218095 | 0 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| CHEMBL433406 | 220419 | 0 | None | 9 | 2 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 10187261 | 118317 | 0 | None | -3 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Cl)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL327976 | 118317 | 0 | None | -3 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Cl)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11489318 | 214578 | 0 | None | -5 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 522 | 8 | 2 | 6 | 4.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96171 | 214578 | 0 | None | -5 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 522 | 8 | 2 | 6 | 4.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 15289330 | 106578 | 0 | None | -18 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 493 | 8 | 1 | 8 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL285368 | 106578 | 0 | None | -18 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 493 | 8 | 1 | 8 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| 10230546 | 114024 | 0 | None | -4 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 538 | 8 | 2 | 7 | 4.0 | COc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL316878 | 114024 | 0 | None | -4 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 538 | 8 | 2 | 7 | 4.0 | COc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11273181 | 214645 | 0 | None | 4 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C(F)(F)F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96506 | 214645 | 0 | None | 4 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C(F)(F)F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 44327659 | 116599 | 0 | None | 1 | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 937 | 26 | 9 | 8 | 4.6 | CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 | 10.1021/jm00015a003 | ||
| CHEMBL323331 | 116599 | 0 | None | 1 | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 937 | 26 | 9 | 8 | 4.6 | CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 | 10.1021/jm00015a003 | ||
| 9955200 | 16104 | 0 | None | -53 | 3 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | ||
| CHEMBL11115 | 16104 | 0 | None | -53 | 3 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm00008a002 | ||
| 345351 | 16131 | 4 | None | -24 | 3 | Rat | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 386 | 4 | 1 | 5 | 3.8 | O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | ||
| CHEMBL11131 | 16131 | 4 | None | -24 | 3 | Rat | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 386 | 4 | 1 | 5 | 3.8 | O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | ||
| 11365059 | 214574 | 0 | None | -1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 564 | 7 | 2 | 6 | 5.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(C)(C)C)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96154 | 214574 | 0 | None | -1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 564 | 7 | 2 | 6 | 5.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(C)(C)C)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11467573 | 114017 | 0 | None | -9 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 606 | 8 | 2 | 7 | 5.0 | COc1ccc(CN2C(=O)CN[C@](c3cccc(C(F)(F)F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL316851 | 114017 | 0 | None | -9 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 606 | 8 | 2 | 7 | 5.0 | COc1ccc(CN2C(=O)CN[C@](c3cccc(C(F)(F)F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11331242 | 114197 | 0 | None | -1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 652 | 8 | 2 | 6 | 7.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL318086 | 114197 | 0 | None | -1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 652 | 8 | 2 | 6 | 7.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11342005 | 214328 | 0 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)c(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL94766 | 214328 | 0 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)c(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11307805 | 114118 | 0 | None | -3 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 586 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Br)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL317589 | 114118 | 0 | None | -3 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 586 | 7 | 2 | 6 | 4.8 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Br)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 10226239 | 214667 | 0 | None | -4 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 456 | 5 | 2 | 8 | 2.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(C)n3-c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96614 | 214667 | 0 | None | -4 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 456 | 5 | 2 | 8 | 2.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(C)n3-c3ccccc32)n1 | 10.1021/jm031115r | ||
| 44328057 | 103669 | 0 | None | 7 | 2 | Rat | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 986 | 26 | 9 | 9 | 4.9 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1cccnc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL265734 | 103669 | 0 | None | 7 | 2 | Rat | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 986 | 26 | 9 | 9 | 4.9 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1cccnc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 11156376 | 119443 | 0 | None | -5 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 504 | 9 | 3 | 7 | 2.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCC(=O)O)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL330359 | 119443 | 0 | None | -5 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 504 | 9 | 3 | 7 | 2.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCC(=O)O)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11375934 | 214692 | 0 | None | -3 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96746 | 214692 | 0 | None | -3 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11156301 | 85439 | 0 | None | -4 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 500 | 7 | 3 | 9 | 2.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(CC(=O)O)n3-c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL2112377 | 85439 | 0 | None | -4 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 500 | 7 | 3 | 9 | 2.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(CC(=O)O)n3-c3ccccc32)n1 | 10.1021/jm031115r | ||
| 10070783 | 103831 | 0 | None | -5 | 3 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 420 | 4 | 1 | 5 | 4.5 | O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | ||
| CHEMBL267094 | 103831 | 0 | None | -5 | 3 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 420 | 4 | 1 | 5 | 4.5 | O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | ||
| 11478911 | 163089 | 0 | None | -4 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 598 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)c(F)c(F)c(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL406551 | 163089 | 0 | None | -4 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 598 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)c(F)c(F)c(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 44327890 | 148190 | 0 | None | 46 | 3 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 985 | 26 | 9 | 8 | 5.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL384052 | 148190 | 0 | None | 46 | 3 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 985 | 26 | 9 | 8 | 5.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 44327656 | 148567 | 0 | None | 1 | 2 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 977 | 25 | 9 | 8 | 4.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL386181 | 148567 | 0 | None | 1 | 2 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 977 | 25 | 9 | 8 | 4.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 11421972 | 214624 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(OC(F)(F)F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96422 | 214624 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(OC(F)(F)F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 345351 | 16131 | 4 | None | -33 | 3 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 386 | 4 | 1 | 5 | 3.8 | O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | ||
| CHEMBL11131 | 16131 | 4 | None | -33 | 3 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 386 | 4 | 1 | 5 | 3.8 | O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | ||
| 11455999 | 214608 | 0 | None | -31 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 580 | 7 | 2 | 4 | 6.6 | O=C(O)[C@@H](Oc1cccc(Cl)c1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 | 10.1021/jm031115r | ||
| CHEMBL96325 | 214608 | 0 | None | -31 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 580 | 7 | 2 | 4 | 6.6 | O=C(O)[C@@H](Oc1cccc(Cl)c1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 | 10.1021/jm031115r | ||
| 10282008 | 213860 | 0 | None | -12 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(OC(F)(F)F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL91873 | 213860 | 0 | None | -12 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(OC(F)(F)F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11364770 | 170435 | 0 | None | -5 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL420435 | 170435 | 0 | None | -5 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11191999 | 214278 | 0 | None | -4 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)ccc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL94438 | 214278 | 0 | None | -4 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)ccc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11168474 | 214684 | 0 | None | -9 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96723 | 214684 | 0 | None | -9 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11308052 | 119442 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 618 | 10 | 2 | 6 | 5.8 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL330354 | 119442 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 618 | 10 | 2 | 6 | 5.8 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 | 10.1021/jm031115r | ||
| 11330570 | 214363 | 0 | None | -4 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 570 | 8 | 2 | 7 | 4.5 | COc1ccc(CN2C(=O)CN[C@](c3ccc(F)c(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL94934 | 214363 | 0 | None | -4 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 570 | 8 | 2 | 7 | 4.5 | COc1ccc(CN2C(=O)CN[C@](c3ccc(F)c(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11432855 | 214633 | 0 | None | -28 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 552 | 8 | 3 | 7 | 3.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(=O)O)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96463 | 214633 | 0 | None | -28 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 552 | 8 | 3 | 7 | 3.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(=O)O)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11444738 | 171658 | 0 | None | -4 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 594 | 11 | 2 | 7 | 5.4 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL422068 | 171658 | 0 | None | -4 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 594 | 11 | 2 | 7 | 5.4 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 | 10.1021/jm031115r | ||
| 44327347 | 103538 | 0 | None | 3 | 3 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 1102 | 26 | 9 | 8 | 7.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1c2ccccc2CCc2ccccc21)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL264579 | 103538 | 0 | None | 3 | 3 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 1102 | 26 | 9 | 8 | 7.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1c2ccccc2CCc2ccccc21)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 11235126 | 214706 | 0 | None | -52 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 405 | 5 | 2 | 6 | 2.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCOc3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96831 | 214706 | 0 | None | -52 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 405 | 5 | 2 | 6 | 2.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCOc3ccccc32)n1 | 10.1021/jm031115r | ||
| 11786120 | 175947 | 0 | None | -17 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 546 | 7 | 2 | 4 | 5.9 | O=C(O)[C@@H](Oc1ccccc1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 | 10.1021/jm031115r | ||
| CHEMBL440507 | 175947 | 0 | None | -17 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 546 | 7 | 2 | 4 | 5.9 | O=C(O)[C@@H](Oc1ccccc1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 | 10.1021/jm031115r | ||
| 11409474 | 214339 | 0 | None | -1 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 502 | 10 | 2 | 6 | 4.4 | CCCCCCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | ||
| CHEMBL94810 | 214339 | 0 | None | -1 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 502 | 10 | 2 | 6 | 4.4 | CCCCCCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | ||
| 9845562 | 11513 | 0 | None | -7 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 | 10.1021/jm00008a002 | ||
| CHEMBL10374 | 11513 | 0 | None | -7 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 | 10.1021/jm00008a002 | ||
| 11330927 | 214286 | 0 | None | -8 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 606 | 9 | 2 | 6 | 5.9 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL94488 | 214286 | 0 | None | -8 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 606 | 9 | 2 | 6 | 5.9 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| 44283270 | 174660 | 0 | None | -1 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| CHEMBL431124 | 174660 | 0 | None | -1 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| 44327881 | 168454 | 0 | None | 2 | 2 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 1044 | 26 | 9 | 8 | 6.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL413179 | 168454 | 0 | None | 2 | 2 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 1044 | 26 | 9 | 8 | 6.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 23670447 | 9803 | 2 | None | -501 | 4 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm00008a002 | ||
| 999 | 9803 | 2 | None | -501 | 4 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm00008a002 | ||
| CHEMBL1204799 | 9803 | 2 | None | -501 | 4 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm00008a002 | ||
| CHEMBL25438 | 9803 | 2 | None | -501 | 4 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm00008a002 | ||
| 9807691 | 106840 | 0 | None | -134 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 553 | 10 | 1 | 10 | 5.3 | COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL287169 | 106840 | 0 | None | -134 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 553 | 10 | 1 | 10 | 5.3 | COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| 9845562 | 11513 | 0 | None | -87 | 3 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 | 10.1021/jm00008a002 | ||
| CHEMBL10374 | 11513 | 0 | None | -87 | 3 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 | 10.1021/jm00008a002 | ||
| 9865706 | 104910 | 0 | None | -1 | 2 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 4.1 | Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | ||
| CHEMBL273613 | 104910 | 0 | None | -1 | 2 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 4.1 | Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | ||
| 11742628 | 105011 | 0 | None | -234 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | ||
| CHEMBL274383 | 105011 | 0 | None | -234 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | ||
| 10166981 | 213867 | 0 | None | -2 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(F)(F)F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL91926 | 213867 | 0 | None | -2 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 576 | 7 | 2 | 6 | 5.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(F)(F)F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11283571 | 214377 | 0 | None | -7 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 508 | 7 | 2 | 6 | 4.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL95013 | 214377 | 0 | None | -7 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 508 | 7 | 2 | 6 | 4.0 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11477664 | 174946 | 0 | None | -6 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 506 | 10 | 2 | 8 | 2.4 | COCCOCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | ||
| CHEMBL433173 | 174946 | 0 | None | -6 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 506 | 10 | 2 | 8 | 2.4 | COCCOCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | ||
| 11408654 | 214715 | 0 | None | -19 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 464 | 7 | 2 | 8 | 1.8 | COc1cc(OC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96906 | 214715 | 0 | None | -19 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 464 | 7 | 2 | 8 | 1.8 | COc1cc(OC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 10230703 | 214638 | 0 | None | -4 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96472 | 214638 | 0 | None | -4 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 542 | 7 | 2 | 6 | 4.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 9870830 | 213493 | 38 | None | -1122 | 5 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00008a002 | ||
| CHEMBL8981 | 213493 | 38 | None | -1122 | 5 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00008a002 | ||
| 11307457 | 214390 | 0 | None | -5 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 556 | 8 | 2 | 7 | 4.2 | COc1ccc(CN2C(=O)CN[C@](c3cccc(F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL95095 | 214390 | 0 | None | -5 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 556 | 8 | 2 | 7 | 4.2 | COc1ccc(CN2C(=O)CN[C@](c3cccc(F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11785813 | 113699 | 0 | None | -8 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL314755 | 113699 | 0 | None | -8 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 526 | 7 | 2 | 6 | 4.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 10209814 | 214050 | 0 | None | -7 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL93084 | 214050 | 0 | None | -7 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11284285 | 114106 | 0 | None | -8 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 552 | 8 | 2 | 7 | 4.3 | COc1ccc(CN2C(=O)CN[C@](c3cccc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL317510 | 114106 | 0 | None | -8 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 552 | 8 | 2 | 7 | 4.3 | COc1ccc(CN2C(=O)CN[C@](c3cccc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11742628 | 105011 | 0 | None | -25 | 3 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | ||
| CHEMBL274383 | 105011 | 0 | None | -25 | 3 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm00008a002 | ||
| 10070783 | 103831 | 0 | None | -3 | 3 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 420 | 4 | 1 | 5 | 4.5 | O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | ||
| CHEMBL267094 | 103831 | 0 | None | -3 | 3 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 420 | 4 | 1 | 5 | 4.5 | O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm00008a002 | ||
| 11490160 | 214280 | 0 | None | -5 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 584 | 8 | 2 | 6 | 5.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(-c4ccccc4)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL94446 | 214280 | 0 | None | -5 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 584 | 8 | 2 | 6 | 5.7 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(-c4ccccc4)cc3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11432418 | 113725 | 0 | None | -6 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL314946 | 113725 | 0 | None | -6 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 10140418 | 112978 | 0 | None | -43 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 476 | 7 | 3 | 7 | 1.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC(=O)O)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL313867 | 112978 | 0 | None | -43 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 476 | 7 | 3 | 7 | 1.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC(=O)O)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 44327585 | 168562 | 0 | None | 14 | 2 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 992 | 26 | 9 | 8 | 5.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL414082 | 168562 | 0 | None | 14 | 2 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 992 | 26 | 9 | 8 | 5.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 11167889 | 214614 | 0 | None | -1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 496 | 7 | 2 | 6 | 3.7 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(Cl)ccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL96351 | 214614 | 0 | None | -1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 496 | 7 | 2 | 6 | 3.7 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(Cl)ccc32)c1 | 10.1021/jm031115r | ||
| 10347783 | 214613 | 0 | None | -32 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 560 | 7 | 2 | 4 | 5.6 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL96347 | 214613 | 0 | None | -32 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 560 | 7 | 2 | 4 | 5.6 | Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 | 10.1021/jm031115r | ||
| 1009 | 6982 | 25 | None | 1621 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL4507261 | ||
| 5310991 | 6982 | 25 | None | 1621 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL4507261 | ||
| CHEMBL332794 | 6982 | 25 | None | 1621 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL4507261 | ||
| 9894443 | 119350 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 576 | 7 | 2 | 6 | 5.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL330104 | 119350 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 576 | 7 | 2 | 6 | 5.3 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11385689 | 119573 | 0 | None | -10 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 462 | 7 | 2 | 6 | 3.0 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL330629 | 119573 | 0 | None | -10 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 462 | 7 | 2 | 6 | 3.0 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)c1 | 10.1021/jm031115r | ||
| 10163956 | 214368 | 0 | None | -10 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 500 | 7 | 3 | 9 | 1.5 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3nn[nH]n3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL94964 | 214368 | 0 | None | -10 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 500 | 7 | 3 | 9 | 1.5 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3nn[nH]n3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11224973 | 114227 | 0 | None | -32 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 460 | 7 | 2 | 6 | 2.9 | CCc1cc(CC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL318270 | 114227 | 0 | None | -32 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 460 | 7 | 2 | 6 | 2.9 | CCc1cc(CC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11353580 | 214717 | 0 | None | -21 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 566 | 9 | 2 | 7 | 4.6 | CCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL96932 | 214717 | 0 | None | -21 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 566 | 9 | 2 | 7 | 4.6 | CCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 | 10.1021/jm031115r | ||
| 11156692 | 174655 | 0 | None | -2 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL431087 | 174655 | 0 | None | -2 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 522 | 7 | 2 | 6 | 4.3 | Cc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11204331 | 119356 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 616 | 10 | 2 | 6 | 6.1 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL330135 | 119356 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 616 | 10 | 2 | 6 | 6.1 | CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| 10303311 | 113939 | 0 | None | -9 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 566 | 8 | 2 | 8 | 3.8 | COC(=O)c1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL316301 | 113939 | 0 | None | -9 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 566 | 8 | 2 | 8 | 3.8 | COC(=O)c1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11202819 | 119341 | 0 | None | -1 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 499 | 6 | 3 | 8 | 3.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3c(C(=O)O)nc(C)n3-c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL330045 | 119341 | 0 | None | -1 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 499 | 6 | 3 | 8 | 3.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3c(C(=O)O)nc(C)n3-c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11478553 | 170229 | 0 | None | -10 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL419879 | 170229 | 0 | None | -10 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11744509 | 12202 | 0 | None | -5 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 450 | 5 | 1 | 6 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 | 10.1021/jm00008a002 | ||
| CHEMBL10733 | 12202 | 0 | None | -5 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 450 | 5 | 1 | 6 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 | 10.1021/jm00008a002 | ||
| 11307120 | 119181 | 0 | None | 4 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 532 | 11 | 2 | 7 | 4.5 | CCCCC[C@]1([C@H](Oc2nc(C)cc(C)n2)C(=O)O)NCC(=O)N(Cc2ccc(OC)cc2)c2ccccc21 | 10.1021/jm031115r | ||
| CHEMBL329744 | 119181 | 0 | None | 4 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 532 | 11 | 2 | 7 | 4.5 | CCCCC[C@]1([C@H](Oc2nc(C)cc(C)n2)C(=O)O)NCC(=O)N(Cc2ccc(OC)cc2)c2ccccc21 | 10.1021/jm031115r | ||
| 11456110 | 214618 | 0 | None | 1 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3OC(F)(F)F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96387 | 214618 | 0 | None | 1 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 592 | 8 | 2 | 7 | 4.9 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3OC(F)(F)F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 18995989 | 107331 | 0 | None | 2 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 583 | 9 | 1 | 9 | 6.6 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL29147 | 107331 | 0 | None | 2 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 583 | 9 | 1 | 9 | 6.6 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 | 10.1016/0960-894X(96)00232-6 | ||
| 11318559 | 214581 | 0 | None | -5 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 531 | 8 | 2 | 8 | 2.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN3CCOCC3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96193 | 214581 | 0 | None | -5 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 531 | 8 | 2 | 8 | 2.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN3CCOCC3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11410410 | 214329 | 0 | None | -25 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 560 | 7 | 2 | 4 | 6.2 | Cc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL94769 | 214329 | 0 | None | -25 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 560 | 7 | 2 | 4 | 6.2 | Cc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL413825 | 219866 | 0 | None | 4 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(95)00084-7 | ||||
| 11489946 | 214126 | 0 | None | -2 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 566 | 8 | 2 | 7 | 4.6 | COc1ccc(CN2C(=O)CN[C@](c3cc(C)cc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL93612 | 214126 | 0 | None | -2 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 566 | 8 | 2 | 7 | 4.6 | COc1ccc(CN2C(=O)CN[C@](c3cc(C)cc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11785180 | 118285 | 0 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 492 | 8 | 2 | 7 | 3.1 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)ccc32)c1 | 10.1021/jm031115r | ||
| CHEMBL327823 | 118285 | 0 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 492 | 8 | 2 | 7 | 3.1 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)ccc32)c1 | 10.1021/jm031115r | ||
| 11238500 | 214603 | 0 | None | -3 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 572 | 8 | 2 | 7 | 4.7 | COc1ccc(CN2C(=O)CN[C@](c3cccc(Cl)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL96313 | 214603 | 0 | None | -3 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 572 | 8 | 2 | 7 | 4.7 | COc1ccc(CN2C(=O)CN[C@](c3cccc(Cl)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11441050 | 214610 | 0 | None | -85 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 403 | 5 | 2 | 5 | 3.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCCc3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96331 | 214610 | 0 | None | -85 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 403 | 5 | 2 | 5 | 3.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCCc3ccccc32)n1 | 10.1021/jm031115r | ||
| 11398818 | 174710 | 0 | None | -2 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 556 | 8 | 2 | 7 | 4.2 | COc1ccc(CN2C(=O)CN[C@](c3ccccc3F)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL431460 | 174710 | 0 | None | -2 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 556 | 8 | 2 | 7 | 4.2 | COc1ccc(CN2C(=O)CN[C@](c3ccccc3F)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11168401 | 119081 | 0 | None | -18 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 522 | 9 | 2 | 8 | 3.1 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)c(OC)cc32)c1 | 10.1021/jm031115r | ||
| CHEMBL329132 | 119081 | 0 | None | -18 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 522 | 9 | 2 | 8 | 3.1 | COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)c(OC)cc32)c1 | 10.1021/jm031115r | ||
| 11489174 | 119325 | 0 | None | 1 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 514 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CCCCC3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL329943 | 119325 | 0 | None | 1 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 514 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CCCCC3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 10166543 | 119139 | 0 | None | -33 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL329477 | 119139 | 0 | None | -33 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 562 | 7 | 2 | 6 | 4.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11387934 | 113954 | 0 | None | -28 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 614 | 9 | 2 | 7 | 5.7 | COc1ccc(CN2C(=O)CN[C@](c3cccc(-c4ccccc4)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL316453 | 113954 | 0 | None | -28 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 614 | 9 | 2 | 7 | 5.7 | COc1ccc(CN2C(=O)CN[C@](c3cccc(-c4ccccc4)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11157599 | 170262 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 588 | 8 | 2 | 4 | 7.0 | CC(C)c1ccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL420072 | 170262 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 588 | 8 | 2 | 4 | 7.0 | CC(C)c1ccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11155687 | 214606 | 0 | None | -12 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 472 | 7 | 2 | 6 | 3.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CC3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL96318 | 214606 | 0 | None | -12 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 472 | 7 | 2 | 6 | 3.2 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CC3)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 11377200 | 115075 | 0 | None | -11 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 638 | 8 | 2 | 6 | 6.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| CHEMBL319754 | 115075 | 0 | None | -11 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 638 | 8 | 2 | 6 | 6.1 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 | 10.1021/jm031115r | ||
| 44327466 | 103226 | 0 | None | 16 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 966 | 25 | 9 | 8 | 5.2 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(C)(C)C)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL262229 | 103226 | 0 | None | 16 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 966 | 25 | 9 | 8 | 5.2 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(C)(C)C)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL319537 | 217998 | 0 | None | -2 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 11362537 | 114298 | 0 | None | -24 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 434 | 6 | 2 | 7 | 1.8 | COc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 | 10.1021/jm031115r | ||
| CHEMBL318683 | 114298 | 0 | None | -24 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 434 | 6 | 2 | 7 | 1.8 | COc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 | 10.1021/jm031115r | ||
| 44327348 | 168686 | 0 | None | -1 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 1076 | 28 | 9 | 8 | 7.0 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL415238 | 168686 | 0 | None | -1 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 1076 | 28 | 9 | 8 | 7.0 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL407933 | 219473 | 0 | None | -1 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 11342089 | 113985 | 0 | None | -9 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 568 | 9 | 2 | 8 | 4.0 | COc1ccc(CN2C(=O)CN[C@](c3cccc(OC)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL316629 | 113985 | 0 | None | -9 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 568 | 9 | 2 | 8 | 4.0 | COc1ccc(CN2C(=O)CN[C@](c3cccc(OC)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 11488556 | 214648 | 0 | None | -10 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 482 | 5 | 2 | 6 | 2.6 | CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncc(Br)cn2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | ||
| CHEMBL96520 | 214648 | 0 | None | -10 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 482 | 5 | 2 | 6 | 2.6 | CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncc(Br)cn2)C(=O)O)c2ccccc21 | 10.1021/jm031115r | ||
| 11226767 | 214305 | 0 | None | -6 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 560 | 7 | 2 | 4 | 6.2 | Cc1ccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| CHEMBL94606 | 214305 | 0 | None | -6 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 560 | 7 | 2 | 4 | 6.2 | Cc1ccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)cc1 | 10.1021/jm031115r | ||
| 9809919 | 211188 | 0 | None | - | 2 | Rat | 6.0 | pKd | = | 6 | Functional | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL72037 | 211188 | 0 | None | - | 2 | Rat | 6.0 | pKd | = | 6 | Functional | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 18184194 | 137340 | 0 | None | - | 2 | Rat | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | 712 | 15 | 2 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL368107 | 137340 | 0 | None | - | 2 | Rat | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | 712 | 15 | 2 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 9831249 | 66471 | 0 | None | - | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 672 | 14 | 2 | 10 | 6.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL172297 | 66471 | 0 | None | - | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 672 | 14 | 2 | 10 | 6.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 9985589 | 175022 | 0 | None | - | 1 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 576 | 9 | 1 | 8 | 5.0 | CCN(c1ccc2c(c1)oc1c(-c3ccc(OC)cc3)c(C(=O)O)c(=O)n(Cc3ccccc3OC)c12)S(C)(=O)=O | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL433700 | 175022 | 0 | None | - | 1 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 576 | 9 | 1 | 8 | 5.0 | CCN(c1ccc2c(c1)oc1c(-c3ccc(OC)cc3)c(C(=O)O)c(=O)n(Cc3ccccc3OC)c12)S(C)(=O)=O | 10.1016/s0960-894x(99)00040-2 | ||
| 104865 | 7493 | 99 | None | -11 | 5 | Rat | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 3494 | 7493 | 99 | None | -11 | 5 | Rat | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 392 | 7493 | 99 | None | -11 | 5 | Rat | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL957 | 7493 | 99 | None | -11 | 5 | Rat | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| DB00559 | 7493 | 99 | None | -11 | 5 | Rat | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 9848132 | 214356 | 0 | None | - | 2 | Human | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 483 | 6 | 1 | 8 | 2.8 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL94918 | 214356 | 0 | None | - | 2 | Human | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 483 | 6 | 1 | 8 | 2.8 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| 9961131 | 138935 | 0 | None | - | 2 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 650 | 15 | 2 | 12 | 3.1 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL369676 | 138935 | 0 | None | - | 2 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 650 | 15 | 2 | 12 | 3.1 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 9809919 | 211188 | 0 | None | - | 2 | Rat | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL72037 | 211188 | 0 | None | - | 2 | Rat | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 9809270 | 138118 | 0 | None | - | 2 | Rat | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 622 | 14 | 2 | 12 | 2.3 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL368738 | 138118 | 0 | None | - | 2 | Rat | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 622 | 14 | 2 | 12 | 2.3 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 9873255 | 66408 | 0 | None | - | 2 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 591 | 14 | 2 | 10 | 3.8 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL172071 | 66408 | 0 | None | - | 2 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 591 | 14 | 2 | 10 | 3.8 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 18184234 | 68983 | 0 | None | - | 2 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL177802 | 68983 | 0 | None | - | 2 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 9807691 | 106840 | 0 | None | -134 | 2 | Human | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 553 | 10 | 1 | 10 | 5.3 | COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL287169 | 106840 | 0 | None | -134 | 2 | Human | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 553 | 10 | 1 | 10 | 5.3 | COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| 9810571 | 68160 | 0 | None | - | 2 | Rat | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 731 | 18 | 2 | 13 | 5.0 | CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL176997 | 68160 | 0 | None | - | 2 | Rat | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 731 | 18 | 2 | 13 | 5.0 | CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 9897092 | 66710 | 0 | None | - | 2 | Rat | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 779 | 17 | 2 | 13 | 6.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL173201 | 66710 | 0 | None | - | 2 | Rat | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 779 | 17 | 2 | 13 | 6.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 18184229 | 66382 | 0 | None | - | 2 | Rat | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL171950 | 66382 | 0 | None | - | 2 | Rat | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 9853680 | 105424 | 0 | None | - | 2 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 771 | 17 | 2 | 14 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL277275 | 105424 | 0 | None | - | 2 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 771 | 17 | 2 | 14 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 9830773 | 137004 | 0 | None | - | 2 | Rat | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 636 | 14 | 2 | 12 | 2.8 | CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL367958 | 137004 | 0 | None | - | 2 | Rat | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 636 | 14 | 2 | 12 | 2.8 | CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 9874557 | 136516 | 0 | None | - | 2 | Rat | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 667 | 15 | 2 | 10 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL367443 | 136516 | 0 | None | - | 2 | Rat | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 667 | 15 | 2 | 10 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 9831527 | 136260 | 0 | None | - | 2 | Rat | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 698 | 14 | 2 | 12 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL367274 | 136260 | 0 | None | - | 2 | Rat | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 698 | 14 | 2 | 12 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 9957883 | 105433 | 0 | None | -25 | 2 | Human | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL27732 | 105433 | 0 | None | -25 | 2 | Human | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| 18995992 | 106614 | 0 | None | -3 | 2 | Human | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL28563 | 106614 | 0 | None | -3 | 2 | Human | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| 9917072 | 68877 | 0 | None | - | 2 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 619 | 16 | 2 | 10 | 4.6 | CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL177538 | 68877 | 0 | None | - | 2 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 619 | 16 | 2 | 10 | 4.6 | CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 9853077 | 66401 | 0 | None | - | 2 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 696 | 13 | 2 | 12 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL172030 | 66401 | 0 | None | - | 2 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 696 | 13 | 2 | 12 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 9917706 | 136517 | 0 | None | - | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 659 | 15 | 2 | 11 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL367444 | 136517 | 0 | None | - | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 659 | 15 | 2 | 11 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 13016 | 7457 | 13 | None | - | 0 | Human | 4.7 | pKi | = | 4.7 | Functional | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1021/jm030480f | ||
| 9843631 | 7457 | 13 | None | - | 0 | Human | 4.7 | pKi | = | 4.7 | Functional | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1021/jm030480f | ||
| CHEMBL24461 | 7457 | 13 | None | - | 0 | Human | 4.7 | pKi | = | 4.7 | Functional | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1021/jm030480f | ||
| 10096179 | 183799 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCOc1ccc(-c2cc(C)nc(OC(C(=O)O)C(C)(c3ccccc3)c3ccccc3)n2)cc1 | 10.1016/s0960-894x(03)00236-1 | ||
| CHEMBL46311 | 183799 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCOc1ccc(-c2cc(C)nc(OC(C(=O)O)C(C)(c3ccccc3)c3ccccc3)n2)cc1 | 10.1016/s0960-894x(03)00236-1 | ||
| 10070 | 7237 | 47 | None | -109 | 2 | Human | 5.5 | pA2 | = | 5.5 | Functional | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | ||
| 25099191 | 7237 | 47 | None | -109 | 2 | Human | 5.5 | pA2 | = | 5.5 | Functional | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | ||
| CHEMBL2165326 | 7237 | 47 | None | -109 | 2 | Human | 5.5 | pA2 | = | 5.5 | Functional | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | ||
| DB15059 | 7237 | 47 | None | -109 | 2 | Human | 5.5 | pA2 | = | 5.5 | Functional | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | ||
| 104865 | 7493 | 99 | None | -11 | 5 | Rat | 6.0 | pA2 | = | 6 | Functional | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | ||
| 3494 | 7493 | 99 | None | -11 | 5 | Rat | 6.0 | pA2 | = | 6 | Functional | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | ||
| 392 | 7493 | 99 | None | -11 | 5 | Rat | 6.0 | pA2 | = | 6 | Functional | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | ||
| CHEMBL957 | 7493 | 99 | None | -11 | 5 | Rat | 6.0 | pA2 | = | 6 | Functional | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | ||
| DB00559 | 7493 | 99 | None | -11 | 5 | Rat | 6.0 | pA2 | = | 6 | Functional | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | ||
| 3913 | 10509 | 0 | None | 1 | 2 | Rat | 8.4 | pA2 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 7780649 | ||||
| 5311469 | 10509 | 0 | None | 1 | 2 | Rat | 8.4 | pA2 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 7780649 | ||||
| 104865 | 7493 | 99 | None | -11 | 5 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| 3494 | 7493 | 99 | None | -11 | 5 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| 392 | 7493 | 99 | None | -11 | 5 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| CHEMBL957 | 7493 | 99 | None | -11 | 5 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| DB00559 | 7493 | 99 | None | -11 | 5 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| 3951 | 7179 | 86 | None | -47 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | ||
| 4337 | 7179 | 86 | None | -47 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | ||
| 6918493 | 7179 | 86 | None | -47 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | ||
| CHEMBL1111 | 7179 | 86 | None | -47 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | ||
| DB06403 | 7179 | 86 | None | -47 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Guide to Pharmacology | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 15139756 | ||
| 10070 | 7237 | 47 | None | -109 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | ||
| 25099191 | 7237 | 47 | None | -109 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | ||
| CHEMBL2165326 | 7237 | 47 | None | -109 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | ||
| DB15059 | 7237 | 47 | None | -109 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | Guide to Pharmacology | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 18780830 | ||
| 16004692 | 9232 | 91 | None | -107 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Guide to Pharmacology | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 22862294 | ||
| 4809 | 9232 | 91 | None | -107 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Guide to Pharmacology | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 22862294 | ||
| 7352 | 9232 | 91 | None | -107 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Guide to Pharmacology | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 22862294 | ||
| CHEMBL2103873 | 9232 | 91 | None | -107 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Guide to Pharmacology | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 22862294 | ||
| DB08932 | 9232 | 91 | None | -107 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Guide to Pharmacology | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 22862294 | ||
| 1011 | 10125 | 29 | None | 102 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 609 | 12 | 3 | 10 | 4.8 | OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O | 8612786 | ||
| 5312146 | 10125 | 29 | None | 102 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 609 | 12 | 3 | 10 | 4.8 | OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O | 8612786 | ||
| CHEMBL1628620 | 10125 | 29 | None | 102 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 609 | 12 | 3 | 10 | 4.8 | OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O | 8612786 | ||
| 3911 | 10090 | 0 | None | 501 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | None | None | None | None | 8183252 | ||||
| CHEMBL429908 | 10090 | 0 | None | 501 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | None | None | None | None | 8183252 | ||||
| 9651 | 8955 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 682 | 12 | 2 | 10 | 6.9 | COc1ccccc1Oc1c(OCCC(=O)Nc2c(C)cccc2C)nc(nc1NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 28805809 | ||
| 9810112 | 8955 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 682 | 12 | 2 | 10 | 6.9 | COc1ccccc1Oc1c(OCCC(=O)Nc2c(C)cccc2C)nc(nc1NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 28805809 | ||
| 108002 | 10267 | 23 | None | 1 | 2 | Rat | 9.4 | pKB | = | 9.4 | Functional | Guide to Pharmacology | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 8201588 | ||
| 3528 | 10267 | 23 | None | 1 | 2 | Rat | 9.4 | pKB | = | 9.4 | Functional | Guide to Pharmacology | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 8201588 | ||
| CHEMBL8823 | 10267 | 23 | None | 1 | 2 | Rat | 9.4 | pKB | = | 9.4 | Functional | Guide to Pharmacology | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 8201588 | ||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 4236 | 34869 | 66 | None | - | 1 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 273 | 5 | 1 | 2 | 2.0 | NC(=O)C[S+]([O-])C(c1ccccc1)c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1373 | 34869 | 66 | None | - | 1 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 273 | 5 | 1 | 2 | 2.0 | NC(=O)C[S+]([O-])C(c1ccccc1)c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1038/s41467-023-40064-9 | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1038/s41467-023-40064-9 | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1038/s41467-023-40064-9 | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1038/s41467-023-40064-9 | ||
| 4020 | 211929 | 39 | None | - | 1 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 284 | 1 | 1 | 3 | 2.6 | OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL781 | 211929 | 39 | None | - | 1 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 284 | 1 | 1 | 3 | 2.6 | OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL2370066 | 216556 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| CHEMBL2370067 | 216557 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@H](C=O)Cc1c[nH]c2ccccc12)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| CHEMBL315841 | 217972 | 0 | None | - | 0 | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00070a001 | ||||
| CHEMBL407269 | 219430 | 0 | None | - | 0 | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| CHEMBL387200 | 219187 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| CHEMBL86703 | 222668 | 0 | None | - | 0 | Rat | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C | 10.1021/jm00070a001 | ||||
| CHEMBL313344 | 217891 | 0 | None | - | 0 | Rat | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| CHEMBL1790180 | 215662 | 0 | None | -1 | 3 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.ejmech.2013.01.044 | ||||
| CHEMBL1790180 | 215662 | 0 | None | -1 | 3 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.bmc.2013.03.016 | ||||
| CHEMBL1790180 | 215662 | 0 | None | -1 | 3 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm8007618 | ||||
| CHEMBL438733 | 220570 | 0 | None | - | 0 | Bovine | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]2CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N2)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00077a013 | ||||
| 44284481 | 220504 | 0 | None | - | 5 | Bovine | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00077a013 | ||||
| CHEMBL437472 | 220504 | 0 | None | - | 5 | Bovine | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00077a013 | ||||
| 44284481 | 220504 | 0 | None | -4 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.bmcl.2013.01.025 | ||||
| CHEMBL437472 | 220504 | 0 | None | -4 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.bmcl.2013.01.025 | ||||
| 10603409 | 117381 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | ||
| CHEMBL325581 | 117381 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | ||
| CHEMBL1790962 | 215689 | 0 | None | - | 1 | Bovine | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | ||||
| CHEMBL427748 | 220151 | 0 | None | - | 0 | Bovine | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | ||||
| 10603409 | 117381 | 0 | None | - | 0 | Pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | ||
| CHEMBL325581 | 117381 | 0 | None | - | 0 | Pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | ||
| 10651488 | 170158 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | ||
| CHEMBL419367 | 170158 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | ||
| 44284481 | 220504 | 0 | None | -4 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(97)00400-9 | ||||
| CHEMBL437472 | 220504 | 0 | None | -4 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(97)00400-9 | ||||
| CHEMBL2165327 | 216111 | 7 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm3009103 | ||||
| CHEMBL263855 | 217373 | 0 | None | - | 0 | Bovine | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]cn2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(97)00296-5 | ||||
| CHEMBL2373292 | 217154 | 0 | None | - | 1 | Bovine | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | ||||
| 10839947 | 124080 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 530 | 9 | 2 | 6 | 5.0 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| CHEMBL339657 | 124080 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 530 | 9 | 2 | 6 | 5.0 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| 9916235 | 16125 | 1 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL111277 | 16125 | 1 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| 9916235 | 16125 | 1 | None | - | 0 | Pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL111277 | 16125 | 1 | None | - | 0 | Pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| 10187997 | 116749 | 0 | None | - | 0 | Pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL323464 | 116749 | 0 | None | - | 0 | Pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| 10651488 | 170158 | 0 | None | - | 0 | Pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | ||
| CHEMBL419367 | 170158 | 0 | None | - | 0 | Pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | ||
| CHEMBL1790963 | 215690 | 0 | None | - | 0 | Bovine | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | ||||
| 10210629 | 15536 | 0 | None | - | 0 | Pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL109644 | 15536 | 0 | None | - | 0 | Pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL2373291 | 217153 | 0 | None | - | 1 | Bovine | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00077a013 | ||||
| CHEMBL411171 | 219646 | 0 | None | - | 1 | Bovine | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00077a013 | ||||
| 10187997 | 116749 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL323464 | 116749 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| 10210629 | 15536 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL109644 | 15536 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| 10555806 | 18894 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 616 | 12 | 2 | 7 | 6.0 | CC(C)OCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 | 10.1021/jm990171i | ||
| CHEMBL1184095 | 18894 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 616 | 12 | 2 | 7 | 6.0 | CC(C)OCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 | 10.1021/jm990171i | ||
| CHEMBL332289 | 18894 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 616 | 12 | 2 | 7 | 6.0 | CC(C)OCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 | 10.1021/jm990171i | ||
| 1009 | 6982 | 25 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL5210121 | ||
| 5310991 | 6982 | 25 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL5210121 | ||
| CHEMBL332794 | 6982 | 25 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL5210121 | ||
| 10792711 | 121569 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 548 | 9 | 2 | 6 | 5.2 | CCc1cc(F)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| CHEMBL333972 | 121569 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 548 | 9 | 2 | 6 | 5.2 | CCc1cc(F)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| 44314619 | 211465 | 0 | None | - | 0 | Pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 631 | 12 | 5 | 4 | 4.5 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL73925 | 211465 | 0 | None | - | 0 | Pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 631 | 12 | 5 | 4 | 4.5 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL284250 | 217639 | 0 | None | - | 0 | Pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1016/0960-894X(95)00237-N | ||||
| 9916235 | 16125 | 1 | None | - | 0 | Pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL111277 | 16125 | 1 | None | - | 0 | Pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 578 | 14 | 1 | 7 | 4.6 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| 10816963 | 120106 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 574 | 12 | 2 | 7 | 5.0 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 | 10.1021/jm990170q | ||
| CHEMBL331625 | 120106 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 574 | 12 | 2 | 7 | 5.0 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 | 10.1021/jm990170q | ||
| 9896468 | 177448 | 0 | None | - | 0 | Pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 703 | 13 | 2 | 10 | 6.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCC(=O)Nc1ccccc1C(C)C | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4451582 | 177448 | 0 | None | - | 0 | Pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 703 | 13 | 2 | 10 | 6.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCC(=O)Nc1ccccc1C(C)C | 10.1016/j.bmcl.2016.06.014 | ||
| 10626362 | 18223 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 544 | 8 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 | 10.1021/jm990171i | ||
| CHEMBL1180351 | 18223 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 544 | 8 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 | 10.1021/jm990171i | ||
| CHEMBL123316 | 18223 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 544 | 8 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 | 10.1021/jm990171i | ||
| 10651488 | 170158 | 0 | None | - | 0 | Pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | ||
| CHEMBL419367 | 170158 | 0 | None | - | 0 | Pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 618 | 13 | 1 | 7 | 4.8 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F | 10.1021/jm970101g | ||
| 10187997 | 116749 | 0 | None | - | 0 | Pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL323464 | 116749 | 0 | None | - | 0 | Pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 564 | 13 | 1 | 7 | 4.2 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| 10603409 | 117381 | 0 | None | - | 0 | Pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | ||
| CHEMBL325581 | 117381 | 0 | None | - | 0 | Pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 584 | 13 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl | 10.1021/jm970101g | ||
| 10698065 | 18885 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.6 | CCC(CC)C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| CHEMBL1184065 | 18885 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.6 | CCC(CC)C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| CHEMBL330895 | 18885 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.6 | CCC(CC)C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| 10841170 | 18891 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| CHEMBL1184090 | 18891 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| CHEMBL332109 | 18891 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| 44314619 | 211465 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 631 | 12 | 5 | 4 | 4.5 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL73925 | 211465 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 631 | 12 | 5 | 4 | 4.5 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| 10816963 | 120106 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 574 | 12 | 2 | 7 | 5.0 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 | 10.1021/jm990170q | ||
| CHEMBL331625 | 120106 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 574 | 12 | 2 | 7 | 5.0 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 | 10.1021/jm990170q | ||
| 10167052 | 116416 | 0 | None | - | 0 | Pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 578 | 13 | 1 | 7 | 4.5 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCC(C)C | 10.1021/jm970101g | ||
| CHEMBL322297 | 116416 | 0 | None | - | 0 | Pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 578 | 13 | 1 | 7 | 4.5 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCC(C)C | 10.1021/jm970101g | ||
| 137630807 | 167891 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@@H](NC(=O)[C@@H](Cc1cc2ccccc2n1C(=O)OC)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4075238 | 167891 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@@H](NC(=O)[C@@H](Cc1cc2ccccc2n1C(=O)OC)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4117106 | 167891 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@@H](NC(=O)[C@@H](Cc1cc2ccccc2n1C(=O)OC)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/j.bmcl.2017.04.049 | ||
| 10792636 | 175294 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 544 | 10 | 2 | 6 | 5.4 | CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 | 10.1021/jm990170q | ||
| CHEMBL435385 | 175294 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 544 | 10 | 2 | 6 | 5.4 | CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 | 10.1021/jm990170q | ||
| CHEMBL2370534 | 216648 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](N)Cc2ccccc2)C(C)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm990170q | ||||
| 155560344 | 183282 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/acs.jmedchem.5b01781 | ||
| CHEMBL4568795 | 183282 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/acs.jmedchem.5b01781 | ||
| CHEMBL4596821 | 183282 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/acs.jmedchem.5b01781 | ||
| 44283453 | 145555 | 0 | None | - | 0 | Pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)C(CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| CHEMBL37807 | 145555 | 0 | None | - | 0 | Pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 641 | 12 | 4 | 7 | 4.8 | CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)C(CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| 44314620 | 109922 | 0 | None | - | 0 | Pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 587 | 12 | 5 | 4 | 4.4 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL307903 | 109922 | 0 | None | - | 0 | Pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 587 | 12 | 5 | 4 | 4.4 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| 3887 | 8853 | 45 | None | -7 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01781 | ||||
| 5311192 | 8853 | 45 | None | -7 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01781 | ||||
| CHEMBL72410 | 8853 | 45 | None | -7 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01781 | ||||
| 10839947 | 124080 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 530 | 9 | 2 | 6 | 5.0 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| CHEMBL339657 | 124080 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 530 | 9 | 2 | 6 | 5.0 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| 10210629 | 15536 | 0 | None | - | 0 | Pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL109644 | 15536 | 0 | None | - | 0 | Pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm970101g | ||
| 10792934 | 170692 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 6 | 5.6 | CCc1cc(CC)c(NC(=O)CN2C[C@H](c3ccc4c(c3)OCO4)[C@@H](C(=O)O)[C@@H]2c2ccc(OC)cc2)c(CC)c1 | 10.1021/jm990170q | ||
| CHEMBL420729 | 170692 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 6 | 5.6 | CCc1cc(CC)c(NC(=O)CN2C[C@H](c3ccc4c(c3)OCO4)[C@@H](C(=O)O)[C@@H]2c2ccc(OC)cc2)c(CC)c1 | 10.1021/jm990170q | ||
| 10120499 | 116533 | 0 | None | - | 0 | Pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 564 | 12 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CC(C)C | 10.1021/jm970101g | ||
| CHEMBL323055 | 116533 | 0 | None | - | 0 | Pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 564 | 12 | 1 | 7 | 4.1 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CC(C)C | 10.1021/jm970101g | ||
| 44314472 | 110575 | 0 | None | - | 0 | Pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 594 | 13 | 5 | 5 | 4.2 | CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL309003 | 110575 | 0 | None | - | 0 | Pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 594 | 13 | 5 | 5 | 4.2 | CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 44284481 | 220504 | 0 | None | 3 | 5 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | ||||
| CHEMBL437472 | 220504 | 0 | None | 3 | 5 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | ||||
| 44283420 | 168571 | 0 | None | - | 0 | Pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 594 | 13 | 5 | 5 | 4.2 | CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| CHEMBL414175 | 168571 | 0 | None | - | 0 | Pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 594 | 13 | 5 | 5 | 4.2 | CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| 10604119 | 18229 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 636 | 12 | 2 | 7 | 5.8 | COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| CHEMBL1180361 | 18229 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 636 | 12 | 2 | 7 | 5.8 | COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| CHEMBL123654 | 18229 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 636 | 12 | 2 | 7 | 5.8 | COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| 9846994 | 112766 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 458 | 6 | 1 | 6 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL313153 | 112766 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 458 | 6 | 1 | 6 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| 44315008 | 109608 | 0 | None | - | 0 | Pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 13 | 5 | 5 | 4.7 | CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL305524 | 109608 | 0 | None | - | 0 | Pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 13 | 5 | 5 | 4.7 | CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 9961347 | 18734 | 1 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 664 | 13 | 2 | 7 | 6.6 | Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| CHEMBL1182945 | 18734 | 1 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 664 | 13 | 2 | 7 | 6.6 | Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| CHEMBL273642 | 18734 | 1 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 664 | 13 | 2 | 7 | 6.6 | Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| 44315007 | 211327 | 0 | None | - | 0 | Pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 679 | 14 | 5 | 5 | 5.1 | CCCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL72891 | 211327 | 0 | None | - | 0 | Pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 679 | 14 | 5 | 5 | 5.1 | CCCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL411057 | 219639 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(96)00127-8 | ||||
| CHEMBL384792 | 219114 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/S0960-894X(97)00296-5 | ||||
| CHEMBL405599 | 219347 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| CHEMBL413825 | 219866 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(95)00084-7 | ||||
| 10627805 | 23351 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 630 | 7 | 2 | 6 | 5.4 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(Br)cccc2Br)cc1 | 10.1021/jm990170q | ||
| CHEMBL123926 | 23351 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 630 | 7 | 2 | 6 | 5.4 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(Br)cccc2Br)cc1 | 10.1021/jm990170q | ||
| 22004774 | 107586 | 0 | None | - | 0 | Pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 442 | 8 | 1 | 6 | 5.7 | CCCCSC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL293192 | 107586 | 0 | None | - | 0 | Pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 442 | 8 | 1 | 6 | 5.7 | CCCCSC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 10146305 | 181050 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 656 | 14 | 2 | 13 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2cccs2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4549357 | 181050 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 656 | 14 | 2 | 13 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2cccs2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 44385008 | 138139 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 574 | 10 | 2 | 9 | 4.9 | C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL368829 | 138139 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 574 | 10 | 2 | 9 | 4.9 | C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 44333867 | 11414 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 403 | 4 | 1 | 5 | 4.1 | COc1ccc([C@@H]2c3nc(C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL103001 | 11414 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 403 | 4 | 1 | 5 | 4.1 | COc1ccc([C@@H]2c3nc(C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| 44284196 | 107299 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 504 | 9 | 2 | 7 | 5.4 | CCCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL291247 | 107299 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 504 | 9 | 2 | 7 | 5.4 | CCCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| 9853025 | 66591 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 690 | 14 | 2 | 13 | 3.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL172759 | 66591 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 690 | 14 | 2 | 13 | 3.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.8b00435 | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.8b00435 | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.8b00435 | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.8b00435 | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.8b00435 | ||
| CHEMBL407188 | 219424 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00296-5 | ||||
| 44284481 | 220504 | 0 | None | - | 5 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(97)00296-5 | ||||
| CHEMBL437472 | 220504 | 0 | None | - | 5 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(97)00296-5 | ||||
| 10814440 | 104923 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)ccc2OC)cc1 | 10.1021/jm9606507 | ||
| CHEMBL273723 | 104923 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)ccc2OC)cc1 | 10.1021/jm9606507 | ||
| 44279383 | 106770 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.2 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccccc3)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL286687 | 106770 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.2 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccccc3)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| 122044 | 16945 | 51 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 3.7 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL115951 | 16945 | 51 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 3.7 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 | 10.1016/j.bmcl.2016.06.014 | ||
| 17869373 | 21406 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 460 | 8 | 1 | 7 | 4.7 | COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1205094 | 21406 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 460 | 8 | 1 | 7 | 4.7 | COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL51890 | 21406 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 460 | 8 | 1 | 7 | 4.7 | COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| 44276969 | 113616 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 506 | 7 | 1 | 5 | 4.8 | COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144607 | 113616 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 506 | 7 | 1 | 5 | 4.8 | COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 44311225 | 211486 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 581 | 11 | 1 | 10 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1ccoc1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL74118 | 211486 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 581 | 11 | 1 | 10 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1ccoc1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL269428 | 217566 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 44267002 | 105335 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 546 | 5 | 1 | 7 | 5.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3c2CCc2ccccc2C3=O)cc1 | 10.1021/jm9606507 | ||
| CHEMBL276601 | 105335 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 546 | 5 | 1 | 7 | 5.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3c2CCc2ccccc2C3=O)cc1 | 10.1021/jm9606507 | ||
| 10552883 | 116781 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 484 | 13 | 1 | 5 | 4.8 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C1CC1 | 10.1021/jm980217s | ||
| CHEMBL323485 | 116781 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 484 | 13 | 1 | 5 | 4.8 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C1CC1 | 10.1021/jm980217s | ||
| 11100307 | 209980 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 354 | 5 | 1 | 5 | 3.8 | CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | ||
| CHEMBL64340 | 209980 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 354 | 5 | 1 | 5 | 3.8 | CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | ||
| CHEMBL289687 | 217654 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | ||||
| 10453733 | 119088 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 402 | 9 | 1 | 5 | 4.8 | Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cccnc2)ccc1C#N | 10.1021/jm9707131 | ||
| CHEMBL329181 | 119088 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 402 | 9 | 1 | 5 | 4.8 | Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cccnc2)ccc1C#N | 10.1021/jm9707131 | ||
| 11797717 | 213840 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 448 | 10 | 2 | 5 | 6.0 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc[nH]n1 | 10.1021/jm9707131 | ||
| CHEMBL91753 | 213840 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 448 | 10 | 2 | 5 | 6.0 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc[nH]n1 | 10.1021/jm9707131 | ||
| 10668808 | 213940 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 402 | 9 | 1 | 5 | 4.8 | Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccncc2)ccc1C#N | 10.1021/jm9707131 | ||
| CHEMBL92353 | 213940 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 402 | 9 | 1 | 5 | 4.8 | Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccncc2)ccc1C#N | 10.1021/jm9707131 | ||
| 10504148 | 214038 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 459 | 10 | 1 | 5 | 6.7 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ccccn1 | 10.1021/jm9707131 | ||
| CHEMBL92965 | 214038 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 459 | 10 | 1 | 5 | 6.7 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ccccn1 | 10.1021/jm9707131 | ||
| 10599453 | 214051 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 5.2 | Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N | 10.1021/jm9707131 | ||
| CHEMBL93097 | 214051 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 5.2 | Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N | 10.1021/jm9707131 | ||
| 10740214 | 214083 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 408 | 9 | 1 | 6 | 4.9 | Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cnsc2)ccc1C#N | 10.1021/jm9707131 | ||
| CHEMBL93331 | 214083 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 408 | 9 | 1 | 6 | 4.9 | Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cnsc2)ccc1C#N | 10.1021/jm9707131 | ||
| 10693679 | 214152 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 425 | 10 | 2 | 5 | 4.7 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(N)=O | 10.1021/jm9707131 | ||
| CHEMBL93749 | 214152 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 425 | 10 | 2 | 5 | 4.7 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(N)=O | 10.1021/jm9707131 | ||
| 11796594 | 214157 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 424 | 10 | 1 | 5 | 5.8 | CC(=O)c1ccc(OCc2ccsc2)cc1OC(CCC(=O)O)c1ccccc1C | 10.1021/jm9707131 | ||
| CHEMBL93776 | 214157 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 424 | 10 | 1 | 5 | 5.8 | CC(=O)c1ccc(OCc2ccsc2)cc1OC(CCC(=O)O)c1ccccc1C | 10.1021/jm9707131 | ||
| 10669120 | 214224 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 407 | 9 | 1 | 5 | 5.5 | Cc1ccccc1[C@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N | 10.1021/jm9707131 | ||
| CHEMBL94141 | 214224 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 407 | 9 | 1 | 5 | 5.5 | Cc1ccccc1[C@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N | 10.1021/jm9707131 | ||
| 10694804 | 214599 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 449 | 10 | 1 | 6 | 6.3 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ncco1 | 10.1021/jm9707131 | ||
| CHEMBL96301 | 214599 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 449 | 10 | 1 | 6 | 6.3 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ncco1 | 10.1021/jm9707131 | ||
| CHEMBL289687 | 217654 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | ||||
| 137661460 | 166154 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 565 | 10 | 2 | 9 | 4.4 | C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4100579 | 166154 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 565 | 10 | 2 | 9 | 4.4 | C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 9852624 | 135459 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 656 | 14 | 2 | 11 | 4.5 | CCS(=O)(=O)NCCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL366872 | 135459 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 656 | 14 | 2 | 11 | 4.5 | CCS(=O)(=O)NCCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 10502577 | 19176 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 426 | 7 | 1 | 7 | 3.9 | COc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm9700068 | ||
| CHEMBL1185771 | 19176 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 426 | 7 | 1 | 7 | 3.9 | COc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm9700068 | ||
| CHEMBL432109 | 19176 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 426 | 7 | 1 | 7 | 3.9 | COc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm9700068 | ||
| 10814776 | 106249 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 485 | 5 | 2 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9608366 | ||
| 10814776 | 106249 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 485 | 5 | 2 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| CHEMBL283136 | 106249 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 485 | 5 | 2 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9608366 | ||
| CHEMBL283136 | 106249 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 485 | 5 | 2 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| 18184234 | 68983 | 0 | None | - | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL177802 | 68983 | 0 | None | - | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 9961131 | 138935 | 0 | None | - | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 650 | 15 | 2 | 12 | 3.1 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL369676 | 138935 | 0 | None | - | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 650 | 15 | 2 | 12 | 3.1 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 42630654 | 25176 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 545 | 10 | 2 | 8 | 4.3 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| CHEMBL1271531 | 25176 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 545 | 10 | 2 | 8 | 4.3 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| 10210086 | 68055 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 571 | 10 | 2 | 12 | 3.0 | C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL176664 | 68055 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 571 | 10 | 2 | 12 | 3.0 | C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 42630654 | 25176 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 545 | 10 | 2 | 8 | 4.3 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL1271531 | 25176 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 545 | 10 | 2 | 8 | 4.3 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 11071347 | 124584 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 516 | 11 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 | 10.1021/jm010237l | ||
| CHEMBL340190 | 124584 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 516 | 11 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 | 10.1021/jm010237l | ||
| 44279677 | 109003 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 478 | 2 | 2 | 3 | 4.0 | O=C1c2cc(Br)ccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL30297 | 109003 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 478 | 2 | 2 | 3 | 4.0 | O=C1c2cc(Br)ccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| 10504475 | 213731 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 468 | 8 | 1 | 6 | 3.4 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)C)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9119 | 213731 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 468 | 8 | 1 | 6 | 3.4 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)C)cc1 | 10.1021/jm9505369 | ||
| 44458669 | 91448 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 505 | 6 | 2 | 7 | 3.0 | Cc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL22249 | 91448 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 505 | 6 | 2 | 7 | 3.0 | Cc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | ||
| 10168939 | 138146 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 695 | 11 | 2 | 12 | 5.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL368860 | 138146 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 695 | 11 | 2 | 12 | 5.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| 76320429 | 92616 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 324 | 4 | 1 | 6 | 3.6 | Cc1c(C(=O)O)oc2cccc(OCc3ccc4nonc4c3)c12 | 10.1007/s00044-013-0542-3 | ||
| CHEMBL2296900 | 92616 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 324 | 4 | 1 | 6 | 3.6 | Cc1c(C(=O)O)oc2cccc(OCc3ccc4nonc4c3)c12 | 10.1007/s00044-013-0542-3 | ||
| 10625633 | 213918 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 514 | 12 | 1 | 8 | 2.4 | COCCN(CCOC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9223 | 213918 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 514 | 12 | 1 | 8 | 2.4 | COCCN(CCOC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 10817024 | 18900 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 578 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL1184112 | 18900 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 578 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL332808 | 18900 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 578 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| 11798504 | 103898 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 468 | 9 | 1 | 6 | 3.5 | CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL267695 | 103898 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 468 | 9 | 1 | 6 | 3.5 | CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 71458721 | 88476 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 642 | 14 | 2 | 10 | 4.6 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(C2CC2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163726 | 88476 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 642 | 14 | 2 | 10 | 4.6 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(C2CC2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2304010 | 216245 | 0 | None | - | 0 | Pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Cl)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O | 10.1021/jm9600914 | ||||
| 44320192 | 113833 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 480 | 6 | 1 | 5 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1cccc(Cl)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL315622 | 113833 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 480 | 6 | 1 | 5 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1cccc(Cl)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| 10321290 | 11408 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 445 | 7 | 1 | 5 | 5.1 | CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL102969 | 11408 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 445 | 7 | 1 | 5 | 5.1 | CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| 44284287 | 168026 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 10 | 3 | 7 | 5.2 | CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL411925 | 168026 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 10 | 3 | 7 | 5.2 | CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| 44314657 | 109980 | 0 | None | - | 0 | Pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 619 | 13 | 5 | 4 | 4.3 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL308383 | 109980 | 0 | None | - | 0 | Pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 619 | 13 | 5 | 4 | 4.3 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1)C(=O)O | 10.1021/jm9600914 | ||
| 159594 | 7310 | 45 | None | - | 3 | Pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1016/s0960-894x(98)00301-1 | ||
| 3487 | 7310 | 45 | None | - | 3 | Pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL9194 | 7310 | 45 | None | - | 3 | Pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1016/s0960-894x(98)00301-1 | ||
| DB06199 | 7310 | 45 | None | - | 3 | Pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1016/s0960-894x(98)00301-1 | ||
| 122044 | 16945 | 51 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 3.7 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 | 10.1021/jm0102304 | ||
| CHEMBL115951 | 16945 | 51 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 3.7 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 | 10.1021/jm0102304 | ||
| 15289330 | 106578 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 493 | 8 | 1 | 8 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL285368 | 106578 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 493 | 8 | 1 | 8 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| 18995998 | 169170 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 523 | 9 | 1 | 9 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL416570 | 169170 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 523 | 9 | 1 | 9 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL438768 | 220575 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | ||||
| 15453179 | 212260 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80538 | 212260 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 11783885 | 107664 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 382 | 7 | 1 | 5 | 4.6 | CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | ||
| CHEMBL293702 | 107664 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 382 | 7 | 1 | 5 | 4.6 | CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | ||
| 44279350 | 174955 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 428 | 4 | 2 | 4 | 4.2 | COc1cccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)c1 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL433229 | 174955 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 428 | 4 | 2 | 4 | 4.2 | COc1cccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)c1 | 10.1016/0960-894X(95)00230-Q | ||
| 44314609 | 211527 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 720 | 12 | 6 | 4 | 5.6 | CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL74471 | 211527 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 720 | 12 | 6 | 4 | 5.6 | CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm9600914 | ||
| 44458999 | 175007 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 525 | 6 | 2 | 7 | 3.3 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL433619 | 175007 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 525 | 6 | 2 | 7 | 3.3 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| 44266552 | 11285 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL10218 | 11285 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| 44317109 | 111669 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 472 | 3 | 1 | 4 | 4.1 | Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL311216 | 111669 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 472 | 3 | 1 | 4 | 4.1 | Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 10694591 | 15998 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 444 | 6 | 1 | 6 | 4.6 | CC(C)Oc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL11064 | 15998 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 444 | 6 | 1 | 6 | 4.6 | CC(C)Oc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| 10551532 | 117361 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 450 | 8 | 1 | 4 | 3.9 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL325444 | 117361 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 450 | 8 | 1 | 4 | 3.9 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 10791702 | 202595 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL558148 | 202595 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 15340612 | 113609 | 1 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144599 | 113609 | 1 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL2367550 | 216363 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm970161m | ||||
| 44439103 | 98726 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 859 | 27 | 2 | 14 | 5.3 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 | 10.1016/j.bmcl.2006.10.009 | ||
| CHEMBL241460 | 98726 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 859 | 27 | 2 | 14 | 5.3 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 | 10.1016/j.bmcl.2006.10.009 | ||
| 10836835 | 103876 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 440 | 7 | 2 | 5 | 3.8 | CCCCNC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL267483 | 103876 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 440 | 7 | 2 | 5 | 3.8 | CCCCNC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44351961 | 25608 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 522 | 13 | 1 | 5 | 5.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCC)cc1 | 10.1021/jm010237l | ||
| CHEMBL128061 | 25608 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 522 | 13 | 1 | 5 | 5.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCC)cc1 | 10.1021/jm010237l | ||
| 10218058 | 88444 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 523 | 12 | 2 | 10 | 3.1 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL2163695 | 88444 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 523 | 12 | 2 | 10 | 3.1 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | ||
| 42630532 | 25171 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 4.9 | C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| CHEMBL1271479 | 25171 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 4.9 | C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| 10218058 | 88444 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 523 | 12 | 2 | 10 | 3.1 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO | 10.1021/jm3009103 | ||
| CHEMBL2163695 | 88444 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 523 | 12 | 2 | 10 | 3.1 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO | 10.1021/jm3009103 | ||
| 42630532 | 25171 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 4.9 | C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL1271479 | 25171 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 4.9 | C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 22467230 | 92130 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 536 | 8 | 1 | 8 | 4.0 | COCc1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261601 | 92130 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 536 | 8 | 1 | 8 | 4.0 | COCc1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 | 10.1007/s00044-004-0021-y | ||
| 10281943 | 66838 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 589 | 10 | 1 | 10 | 4.9 | COCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL173743 | 66838 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 589 | 10 | 1 | 10 | 4.9 | COCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 71460536 | 88461 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 589 | 11 | 1 | 12 | 3.1 | COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163712 | 88461 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 589 | 11 | 1 | 12 | 3.1 | COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 23445593 | 67009 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 4.7 | Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL174086 | 67009 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 4.7 | Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00133-9 | ||
| 10553017 | 104883 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 3.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)c2ccccc2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL273476 | 104883 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 3.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)c2ccccc2)cc1 | 10.1021/jm9505369 | ||
| 9807456 | 67247 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 545 | 9 | 1 | 9 | 4.8 | C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL175435 | 67247 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 545 | 9 | 1 | 9 | 4.8 | C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 9852318 | 16386 | 8 | None | -2691 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/acs.jmedchem.5b01781 | ||
| CHEMBL112624 | 16386 | 8 | None | -2691 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/acs.jmedchem.5b01781 | ||
| CHEMBL1627022 | 16386 | 8 | None | -2691 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/acs.jmedchem.5b01781 | ||
| CHEMBL263294 | 217343 | 0 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(96)00127-8 | ||||
| CHEMBL385492 | 219131 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | ||||
| 1009 | 6982 | 25 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.1021/jm990170q | ||
| 5310991 | 6982 | 25 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.1021/jm990170q | ||
| CHEMBL332794 | 6982 | 25 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.1021/jm990170q | ||
| 9852318 | 16386 | 8 | None | -2691 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | ||
| CHEMBL112624 | 16386 | 8 | None | -2691 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | ||
| CHEMBL1627022 | 16386 | 8 | None | -2691 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | ||
| 21462932 | 55909 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.6 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc(NS(C)(=O)=O)ccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL156194 | 55909 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.6 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc(NS(C)(=O)=O)ccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| 10173807 | 57656 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL157742 | 57656 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL410321 | 219591 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(96)00127-8 | ||||
| 9825494 | 209389 | 0 | None | - | 0 | Pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL61211 | 209389 | 0 | None | - | 0 | Pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL2304007 | 216242 | 0 | None | - | 0 | Pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O | 10.1021/jm9600914 | ||||
| 155551580 | 180772 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 526 | 12 | 2 | 10 | 3.0 | CCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4542394 | 180772 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 526 | 12 | 2 | 10 | 3.0 | CCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 11757759 | 181225 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 570 | 13 | 2 | 10 | 2.8 | COCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4553625 | 181225 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 570 | 13 | 2 | 10 | 2.8 | COCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 9870830 | 213493 | 38 | None | -66 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL8981 | 213493 | 38 | None | -66 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | ||
| 44311135 | 210969 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 607 | 11 | 2 | 10 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70800 | 210969 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 607 | 11 | 2 | 10 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 8260 | 7319 | 54 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 9912992 | 7319 | 54 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL3989834 | 7319 | 54 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 15453180 | 112002 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 348 | 4 | 1 | 4 | 4.1 | Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Cl | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL311510 | 112002 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 348 | 4 | 1 | 4 | 4.1 | Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Cl | 10.1016/0960-894X(96)00441-6 | ||
| 10288020 | 21401 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 430 | 7 | 1 | 6 | 4.7 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1205067 | 21401 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 430 | 7 | 1 | 6 | 4.7 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL48881 | 21401 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 430 | 7 | 1 | 6 | 4.7 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| 44266646 | 105341 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 475 | 6 | 1 | 8 | 4.5 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/s0960-894x(97)10151-2 | ||
| CHEMBL276638 | 105341 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 475 | 6 | 1 | 8 | 4.5 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/s0960-894x(97)10151-2 | ||
| 10310877 | 210668 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 473 | 8 | 1 | 7 | 5.9 | CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1ccc2nsnc2c1 | 10.1016/s0960-894x(97)10151-2 | ||
| CHEMBL68896 | 210668 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 473 | 8 | 1 | 7 | 5.9 | CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1ccc2nsnc2c1 | 10.1016/s0960-894x(97)10151-2 | ||
| 10769526 | 109477 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 578 | 12 | 2 | 10 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCC(=O)O)c2)cc1 | 10.1021/jm980504w | ||
| CHEMBL304762 | 109477 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 578 | 12 | 2 | 10 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCC(=O)O)c2)cc1 | 10.1021/jm980504w | ||
| 44211959 | 62210 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 620 | 12 | 1 | 9 | 5.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(C)(=O)=O)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL16197 | 62210 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 620 | 12 | 1 | 9 | 5.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(C)(=O)=O)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| 44327412 | 214360 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 497 | 5 | 1 | 8 | 3.0 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL94929 | 214360 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 497 | 5 | 1 | 8 | 3.0 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| 11038320 | 25645 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 492 | 11 | 1 | 4 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 | 10.1021/jm010237l | ||
| CHEMBL128240 | 25645 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 492 | 11 | 1 | 4 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 | 10.1021/jm010237l | ||
| 10501279 | 104994 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 402 | 6 | 1 | 5 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3cccc(OC)c3)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL274307 | 104994 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 402 | 6 | 1 | 5 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3cccc(OC)c3)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| 44277368 | 113622 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 480 | 8 | 2 | 7 | 3.0 | COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c(OCC(=O)O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144733 | 113622 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 480 | 8 | 2 | 7 | 3.0 | COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c(OCC(=O)O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 44386144 | 68758 | 0 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 555 | 9 | 3 | 7 | 5.2 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)n2ccc3ccccc32)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL177431 | 68758 | 0 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 555 | 9 | 3 | 7 | 5.2 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)n2ccc3ccccc32)nc1C(=O)O | 10.1021/jm950592+ | ||
| 44266575 | 11415 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 459 | 6 | 1 | 7 | 5.2 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL10302 | 11415 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 459 | 6 | 1 | 7 | 5.2 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| 9830773 | 137004 | 0 | None | - | 2 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 636 | 14 | 2 | 12 | 2.8 | CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL367958 | 137004 | 0 | None | - | 2 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 636 | 14 | 2 | 12 | 2.8 | CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 44291897 | 108070 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 482 | 7 | 2 | 9 | 3.6 | COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 | 10.1021/jm9608366 | ||
| CHEMBL296456 | 108070 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 482 | 7 | 2 | 9 | 3.6 | COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 | 10.1021/jm9608366 | ||
| 9956918 | 177662 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 482 | 7 | 2 | 9 | 3.6 | COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1OC | 10.1021/jm9700068 | ||
| CHEMBL44544 | 177662 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 482 | 7 | 2 | 9 | 3.6 | COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1OC | 10.1021/jm9700068 | ||
| 10190108 | 137476 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 681 | 12 | 2 | 12 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL368386 | 137476 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 681 | 12 | 2 | 12 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| 19432672 | 211000 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 606 | 11 | 3 | 9 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCNC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70924 | 211000 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 606 | 11 | 3 | 9 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCNC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 23445333 | 134584 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 484 | 6 | 1 | 7 | 4.4 | Cc1cc2c(cc1CCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL366378 | 134584 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 484 | 6 | 1 | 7 | 4.4 | Cc1cc2c(cc1CCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00133-9 | ||
| 10599829 | 103904 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 454 | 9 | 2 | 6 | 3.2 | CCCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL267761 | 103904 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 454 | 9 | 2 | 6 | 3.2 | CCCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44368390 | 52080 | 0 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 475 | 9 | 2 | 6 | 3.9 | COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccc(O)cc2)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL152654 | 52080 | 0 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 475 | 9 | 2 | 6 | 3.9 | COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccc(O)cc2)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| 71462321 | 88782 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 584 | 12 | 2 | 8 | 4.2 | CCc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2165335 | 88782 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 584 | 12 | 2 | 8 | 4.2 | CCc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | ||
| 10577111 | 213676 | 0 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 493 | 7 | 1 | 6 | 4.0 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)COc2ccc(F)cc2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9084 | 213676 | 0 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 493 | 7 | 1 | 6 | 4.0 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)COc2ccc(F)cc2)cc1 | 10.1021/jm9505369 | ||
| 44371495 | 61019 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 590 | 10 | 1 | 8 | 5.4 | CCCN(c1ccc2c(c1)oc1c(-c3ccc(OC)cc3)c(C(=O)O)c(=O)n(Cc3ccccc3OC)c12)S(C)(=O)=O | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL160768 | 61019 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 590 | 10 | 1 | 8 | 5.4 | CCCN(c1ccc2c(c1)oc1c(-c3ccc(OC)cc3)c(C(=O)O)c(=O)n(Cc3ccccc3OC)c12)S(C)(=O)=O | 10.1016/s0960-894x(99)00040-2 | ||
| 44314575 | 110349 | 0 | None | - | 0 | Pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 601 | 13 | 5 | 5 | 4.2 | CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL308584 | 110349 | 0 | None | - | 0 | Pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 601 | 13 | 5 | 5 | 4.2 | CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 44314723 | 211777 | 0 | None | - | 0 | Pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 583 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL76735 | 211777 | 0 | None | - | 0 | Pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 583 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 44386169 | 138167 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 690 | 12 | 2 | 14 | 3.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL368996 | 138167 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 690 | 12 | 2 | 14 | 3.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| 123883 | 21416 | 1 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 927 | 12 | 9 | 11 | 0.8 | CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm970101g | ||
| CHEMBL1205177 | 21416 | 1 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 927 | 12 | 9 | 11 | 0.8 | CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm970101g | ||
| CHEMBL61425 | 21416 | 1 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 927 | 12 | 9 | 11 | 0.8 | CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm970101g | ||
| 11102201 | 210002 | 0 | None | - | 0 | Pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 9 | 1 | 6 | 5.1 | C=CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL64447 | 210002 | 0 | None | - | 0 | Pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 9 | 1 | 6 | 5.1 | C=CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 11005243 | 210160 | 0 | None | - | 0 | Pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL65337 | 210160 | 0 | None | - | 0 | Pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL2304015 | 216250 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O | 10.1021/jm9600914 | ||||
| 10505755 | 21356 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 506 | 10 | 1 | 8 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10832 | 21356 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 506 | 10 | 1 | 8 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL1204670 | 21356 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 506 | 10 | 1 | 8 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| 44334053 | 11323 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 465 | 5 | 1 | 5 | 5.5 | COc1ccc([C@@H]2c3nc(-c4ccccc4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL102411 | 11323 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 465 | 5 | 1 | 5 | 5.5 | COc1ccc([C@@H]2c3nc(-c4ccccc4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL328942 | 218095 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm970161m | ||||
| 44371516 | 57759 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 7 | 1 | 6 | 5.6 | CCOc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc(OC)cc2)c2oc3ccccc3c21 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL157827 | 57759 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 7 | 1 | 6 | 5.6 | CCOc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc(OC)cc2)c2oc3ccccc3c21 | 10.1016/s0960-894x(99)00040-2 | ||
| 44351968 | 124858 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 12 | 1 | 5 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 | 10.1021/jm010237l | ||
| CHEMBL340575 | 124858 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 12 | 1 | 5 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 | 10.1021/jm010237l | ||
| 44327348 | 168686 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 1076 | 28 | 9 | 8 | 7.0 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL415238 | 168686 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 1076 | 28 | 9 | 8 | 7.0 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL407933 | 219473 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 10503067 | 14942 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 436 | 5 | 1 | 6 | 4.9 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCCC2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10919 | 14942 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 436 | 5 | 1 | 6 | 4.9 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCCC2)cc1 | 10.1021/jm9606507 | ||
| 15411005 | 11532 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 677 | 13 | 1 | 12 | 5.2 | CCOC(=O)C(NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1)C(C)C | 10.1016/S0960-894X(97)00002-4 | ||
| CHEMBL103846 | 11532 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 677 | 13 | 1 | 12 | 5.2 | CCOC(=O)C(NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1)C(C)C | 10.1016/S0960-894X(97)00002-4 | ||
| 11026025 | 209664 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 412 | 7 | 1 | 6 | 4.6 | CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL62669 | 209664 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 412 | 7 | 1 | 6 | 4.6 | CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 11762081 | 210098 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 446 | 7 | 1 | 5 | 5.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL64851 | 210098 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 446 | 7 | 1 | 5 | 5.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL147908 | 215560 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | ||||
| 10649086 | 182032 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 500 | 5 | 3 | 8 | 4.0 | Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| CHEMBL45723 | 182032 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 500 | 5 | 3 | 8 | 4.0 | Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Nc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| 44299023 | 203277 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.7 | CCc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | ||
| CHEMBL56343 | 203277 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.7 | CCc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | ||
| 56681797 | 70098 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 937 | 26 | 9 | 9 | 3.6 | CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC | 10.1021/jm970161m | ||
| CHEMBL1793924 | 70098 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 937 | 26 | 9 | 9 | 3.6 | CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC | 10.1021/jm970161m | ||
| 44270523 | 55390 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 724 | 14 | 1 | 9 | 8.0 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL15573 | 55390 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 724 | 14 | 1 | 9 | 8.0 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| 15453178 | 111530 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 348 | 4 | 1 | 4 | 4.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Cl | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL310739 | 111530 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 348 | 4 | 1 | 4 | 4.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Cl | 10.1016/0960-894X(96)00441-6 | ||
| 18617303 | 112572 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1cccc(S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL312685 | 112572 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1cccc(S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/0960-894X(96)00441-6 | ||
| 18617389 | 170257 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 408 | 3 | 1 | 4 | 3.6 | Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL420029 | 170257 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 408 | 3 | 1 | 4 | 3.6 | Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 18617374 | 212295 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 350 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80808 | 212295 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 350 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL414917 | 219939 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | None | None | None | NC(=O)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00084-7 | ||||
| 10575552 | 118086 | 0 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 4.2 | CCCN(C)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL326690 | 118086 | 0 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 4.2 | CCCN(C)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL2369710 | 216432 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00152-J | ||||
| 9915028 | 16183 | 18 | None | -28183 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm010237l | ||
| CHEMBL111612 | 16183 | 18 | None | -28183 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm010237l | ||
| CHEMBL4761843 | 16183 | 18 | None | -28183 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm010237l | ||
| 44385621 | 134974 | 0 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 550 | 10 | 5 | 5 | 4.6 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL366544 | 134974 | 0 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 550 | 10 | 5 | 5 | 4.6 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O | 10.1021/jm950592+ | ||
| 23445537 | 67919 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.9 | CCCc1cc2c(cc1OCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL176538 | 67919 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.9 | CCCc1cc2c(cc1OCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00132-7 | ||
| 44320488 | 113762 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 5 | 1 | 5 | 5.7 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1C1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL315175 | 113762 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 5 | 1 | 5 | 5.7 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1C1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| 23445547 | 119119 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 398 | 4 | 1 | 5 | 4.3 | Cc1noc(NS(=O)(=O)c2cc(-c3ccccc3)cs2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL329375 | 119119 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 398 | 4 | 1 | 5 | 4.3 | Cc1noc(NS(=O)(=O)c2cc(-c3ccccc3)cs2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| 137652304 | 164005 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 544 | 10 | 3 | 8 | 3.7 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCN)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4076290 | 164005 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 544 | 10 | 3 | 8 | 3.7 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCN)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 10119105 | 108224 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 526 | 7 | 2 | 9 | 3.1 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC(=O)N(C)C)OCO3)c1Cl | 10.1021/jm9608366 | ||
| CHEMBL297618 | 108224 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 526 | 7 | 2 | 9 | 3.1 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC(=O)N(C)C)OCO3)c1Cl | 10.1021/jm9608366 | ||
| 11798504 | 103898 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 468 | 9 | 1 | 6 | 3.5 | CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL267695 | 103898 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 468 | 9 | 1 | 6 | 3.5 | CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 23445336 | 66950 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 468 | 6 | 1 | 5 | 5.3 | Cc1cc(C)c(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL173977 | 66950 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 468 | 6 | 1 | 5 | 5.3 | Cc1cc(C)c(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| 44314890 | 111853 | 0 | None | - | 0 | Pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 647 | 12 | 5 | 4 | 5.0 | CC(C)CC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL311384 | 111853 | 0 | None | - | 0 | Pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 647 | 12 | 5 | 4 | 5.0 | CC(C)CC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 44334128 | 11178 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.9 | C=CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL101424 | 11178 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.9 | C=CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| 44334145 | 11424 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 4.6 | COc1ccc([C@@H]2c3nc(N(C)C(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL103090 | 11424 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 4.6 | COc1ccc([C@@H]2c3nc(N(C)C(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| 44284292 | 174891 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 518 | 8 | 3 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)(C)O)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL432856 | 174891 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 518 | 8 | 3 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)(C)O)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 44311346 | 109940 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 681 | 13 | 2 | 13 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL308088 | 109940 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 681 | 13 | 2 | 13 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 17885912 | 113876 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 5.1 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCC(C(=O)O)C1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL315936 | 113876 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 5.1 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCC(C(=O)O)C1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL433406 | 220419 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 15453172 | 211764 | 4 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL76623 | 211764 | 4 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 44298381 | 202683 | 0 | None | - | 0 | Pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 476 | 9 | 2 | 7 | 4.9 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCO)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL55909 | 202683 | 0 | None | - | 0 | Pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 476 | 9 | 2 | 7 | 4.9 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCO)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL2304009 | 216244 | 0 | None | - | 0 | Pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O | 10.1021/jm9600914 | ||||
| CHEMBL86814 | 222671 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | ||||
| 44333721 | 174572 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 447 | 7 | 1 | 6 | 4.3 | CCOCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL430506 | 174572 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 447 | 7 | 1 | 6 | 4.3 | CCOCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL436899 | 220473 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | ||||
| 10916428 | 169474 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 4.4 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL417050 | 169474 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 4.4 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 | 10.1021/jm010382z | ||
| 44295106 | 21514 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 472 | 7 | 1 | 7 | 4.6 | COc1ccc(C(=O)/C(Cc2ccc3c(c2)CCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1206319 | 21514 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 472 | 7 | 1 | 7 | 4.6 | COc1ccc(C(=O)/C(Cc2ccc3c(c2)CCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL262000 | 21514 | 0 | None | - | 0 | Pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 472 | 7 | 1 | 7 | 4.6 | COc1ccc(C(=O)/C(Cc2ccc3c(c2)CCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| 10212163 | 136874 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 696 | 11 | 2 | 13 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL367767 | 136874 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 696 | 11 | 2 | 13 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| 44266646 | 105341 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 475 | 6 | 1 | 8 | 4.5 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL276638 | 105341 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 475 | 6 | 1 | 8 | 4.5 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00170-9 | ||
| 122272 | 103872 | 31 | None | - | 2 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL267458 | 103872 | 31 | None | - | 2 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 345 | 4 | 1 | 5 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 18617345 | 111981 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 384 | 3 | 1 | 4 | 3.9 | Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL311461 | 111981 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 384 | 3 | 1 | 4 | 3.9 | Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 18617314 | 212011 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 334 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL78734 | 212011 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 334 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 3811690 | 212189 | 3 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80129 | 212189 | 3 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL441006 | 220654 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | None | None | None | CC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00084-7 | ||||
| 44277035 | 113629 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 410 | 4 | 1 | 4 | 4.2 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(Cl)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144806 | 113629 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 410 | 4 | 1 | 4 | 4.2 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(Cl)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 10646831 | 190699 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9608366 | ||
| 10646831 | 190699 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9700068 | ||
| CHEMBL48134 | 190699 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9608366 | ||
| CHEMBL48134 | 190699 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9700068 | ||
| CHEMBL1791277 | 215697 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00152-J | ||||
| 10625530 | 213819 | 3 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9162 | 213819 | 3 | None | - | 0 | Pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44266595 | 11165 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 507 | 6 | 1 | 7 | 6.0 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL10136 | 11165 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 507 | 6 | 1 | 7 | 6.0 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| 10766385 | 105204 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 460 | 6 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm9606507 | ||
| CHEMBL275559 | 105204 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 460 | 6 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm9606507 | ||
| 9870959 | 15689 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | ||
| CHEMBL109778 | 15689 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | ||
| 10811595 | 105543 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 411 | 5 | 2 | 6 | 4.1 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm9608366 | ||
| 10811595 | 105543 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 411 | 5 | 2 | 6 | 4.1 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm9700068 | ||
| CHEMBL278114 | 105543 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 411 | 5 | 2 | 6 | 4.1 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm9608366 | ||
| CHEMBL278114 | 105543 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 411 | 5 | 2 | 6 | 4.1 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 | 10.1021/jm9700068 | ||
| 155562688 | 181959 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 554 | 13 | 2 | 10 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4570529 | 181959 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 554 | 13 | 2 | 10 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| 44352026 | 124263 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 548 | 11 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C(F)(F)F)cc1 | 10.1021/jm010237l | ||
| CHEMBL339969 | 124263 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 548 | 11 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C(F)(F)F)cc1 | 10.1021/jm010237l | ||
| 137633653 | 163376 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 593 | 10 | 2 | 9 | 5.0 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4068786 | 163376 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 593 | 10 | 2 | 9 | 5.0 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 44311283 | 109110 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 649 | 11 | 2 | 10 | 6.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL303649 | 109110 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 649 | 11 | 2 | 10 | 6.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 10553490 | 187895 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 501 | 8 | 3 | 10 | 2.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2OCCO)OCO3)c1Cl | 10.1021/jm9608366 | ||
| CHEMBL47604 | 187895 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 501 | 8 | 3 | 10 | 2.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2OCCO)OCO3)c1Cl | 10.1021/jm9608366 | ||
| 71455062 | 88454 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 669 | 14 | 1 | 12 | 5.0 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C(F)(F)F)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163705 | 88454 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 669 | 14 | 1 | 12 | 5.0 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C(F)(F)F)cn1 | 10.1021/jm3009103 | ||
| 44266538 | 12237 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 371 | 4 | 1 | 4 | 4.8 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccccc1 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL10750 | 12237 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 371 | 4 | 1 | 4 | 4.8 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccccc1 | 10.1016/0960-894X(96)00170-9 | ||
| 52950137 | 25206 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 559 | 10 | 3 | 8 | 3.8 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(=O)O)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| CHEMBL1271863 | 25206 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 559 | 10 | 3 | 8 | 3.8 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(=O)O)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| 71456863 | 88465 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL2163716 | 88465 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 71456863 | 88465 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163716 | 88465 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 10625083 | 213425 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 496 | 10 | 1 | 5 | 5.3 | CCCCN(CCCC)C(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL8925 | 213425 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 496 | 10 | 1 | 5 | 5.3 | CCCCN(CCCC)C(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 71460537 | 88472 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 660 | 12 | 1 | 13 | 2.7 | COc1ccccc1Oc1c(NS(=O)(=O)N2CCOCC2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163722 | 88472 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 660 | 12 | 1 | 13 | 2.7 | COc1ccccc1Oc1c(NS(=O)(=O)N2CCOCC2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 21041266 | 88787 | 1 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 584 | 10 | 2 | 8 | 3.3 | O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)NC1CC1 | 10.1021/jm3009103 | ||
| CHEMBL2165340 | 88787 | 1 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 584 | 10 | 2 | 8 | 3.3 | O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)NC1CC1 | 10.1021/jm3009103 | ||
| 44304492 | 103335 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 949 | 23 | 9 | 8 | 4.3 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL262993 | 103335 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 949 | 23 | 9 | 8 | 4.3 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL2304006 | 216241 | 0 | None | - | 0 | Pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | O=C(O)C[C@H]1NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm9600914 | ||||
| 22467235 | 103300 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 533 | 7 | 2 | 7 | 3.8 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1007/s00044-004-0021-y | ||
| CHEMBL262784 | 103300 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 533 | 7 | 2 | 7 | 3.8 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1007/s00044-004-0021-y | ||
| 23288645 | 176506 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 580 | 12 | 3 | 8 | 5.6 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(SC)cc3)cc(C(=O)Nc3ccccc3)cc2OCCO)c1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4438411 | 176506 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 580 | 12 | 3 | 8 | 5.6 | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(SC)cc3)cc(C(=O)Nc3ccccc3)cc2OCCO)c1 | 10.1016/j.bmcl.2016.06.014 | ||
| 9917072 | 68877 | 0 | None | - | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 619 | 16 | 2 | 10 | 4.6 | CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL177538 | 68877 | 0 | None | - | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 619 | 16 | 2 | 10 | 4.6 | CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 44304492 | 103335 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 949 | 23 | 9 | 8 | 4.3 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm970161m | ||
| CHEMBL262993 | 103335 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 949 | 23 | 9 | 8 | 4.3 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm970161m | ||
| 44284287 | 168026 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 532 | 10 | 3 | 7 | 5.2 | CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL411925 | 168026 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 532 | 10 | 3 | 7 | 5.2 | CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL94983 | 222695 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 10983045 | 209685 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 440 | 9 | 1 | 6 | 5.3 | CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL62762 | 209685 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 440 | 9 | 1 | 6 | 5.3 | CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 11144344 | 209791 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 424 | 8 | 1 | 5 | 5.8 | CCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL63267 | 209791 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 424 | 8 | 1 | 5 | 5.8 | CCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL89736 | 222680 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| CHEMBL328942 | 218095 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | ||||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 10671649 | 105342 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 460 | 5 | 1 | 8 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL276639 | 105342 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 460 | 5 | 1 | 8 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| 10961546 | 103534 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL264543 | 103534 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| 18738881 | 86358 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 534 | 7 | 2 | 7 | 4.4 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(=O)O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL2114305 | 86358 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 534 | 7 | 2 | 7 | 4.4 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(=O)O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| 19363918 | 21408 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 474 | 7 | 1 | 8 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc3c(c2)OCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1205106 | 21408 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 474 | 7 | 1 | 8 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc3c(c2)OCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL52535 | 21408 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 474 | 7 | 1 | 8 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc3c(c2)OCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1793934 | 215711 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm970161m | ||||
| 18995988 | 107113 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 389 | 6 | 1 | 4 | 5.5 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3ccccc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL28948 | 107113 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 389 | 6 | 1 | 4 | 5.5 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3ccccc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| 44317215 | 212042 | 2 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 266 | 3 | 1 | 4 | 2.4 | Cc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL78952 | 212042 | 2 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 266 | 3 | 1 | 4 | 2.4 | Cc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/0960-894X(96)00441-6 | ||
| 18617377 | 212253 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 344 | 3 | 1 | 4 | 3.2 | Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80484 | 212253 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 344 | 3 | 1 | 4 | 3.2 | Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/0960-894X(96)00441-6 | ||
| 10665805 | 104954 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 354 | 4 | 1 | 6 | 3.0 | CCC1=C(c2ccc3c(c2)OCO3)C(=O)OC1(O)c1ccc(OC)cc1 | 10.1021/jm9606507 | ||
| CHEMBL273951 | 104954 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 354 | 4 | 1 | 6 | 3.0 | CCC1=C(c2ccc3c(c2)OCO3)C(=O)OC1(O)c1ccc(OC)cc1 | 10.1021/jm9606507 | ||
| CHEMBL413880 | 219873 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | NC(=O)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00084-7 | ||||
| 10882352 | 209762 | 0 | None | - | 0 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 3.4 | CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | ||
| CHEMBL63099 | 209762 | 0 | None | - | 0 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 3.4 | CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | ||
| 44276577 | 113634 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.1 | COc1cccc(Cn2[nH]c(-c3ccc([N+](=O)[O-])cc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144850 | 113634 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.1 | COc1cccc(Cn2[nH]c(-c3ccc([N+](=O)[O-])cc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 44266592 | 12147 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 431 | 4 | 1 | 7 | 4.5 | COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL10699 | 12147 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 431 | 4 | 1 | 7 | 4.5 | COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| 71458718 | 88449 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 615 | 14 | 1 | 12 | 4.3 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163700 | 88449 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 615 | 14 | 1 | 12 | 4.3 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C)cn1 | 10.1021/jm3009103 | ||
| 23445250 | 174885 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 468 | 6 | 1 | 5 | 5.8 | Cc1cc(CC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL432815 | 174885 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 468 | 6 | 1 | 5 | 5.8 | Cc1cc(CC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| 10302118 | 67198 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 533 | 9 | 2 | 10 | 3.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL175111 | 67198 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 533 | 9 | 2 | 10 | 3.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| 18184249 | 135250 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 662 | 13 | 2 | 11 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL366628 | 135250 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 662 | 13 | 2 | 11 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 10528383 | 18007 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 470 | 5 | 1 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)c2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| CHEMBL1178854 | 18007 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 470 | 5 | 1 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)c2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| CHEMBL46357 | 18007 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 470 | 5 | 1 | 8 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)c2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| 9915028 | 16183 | 18 | None | -28183 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| CHEMBL111612 | 16183 | 18 | None | -28183 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| CHEMBL4761843 | 16183 | 18 | None | -28183 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| 9955200 | 16104 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL11115 | 16104 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | ||
| 24997097 | 25245 | 3 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 501 | 7 | 3 | 7 | 4.0 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| CHEMBL1272137 | 25245 | 3 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 501 | 7 | 3 | 7 | 4.0 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| 23445507 | 66534 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 442 | 6 | 1 | 6 | 4.5 | Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL172538 | 66534 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 442 | 6 | 1 | 6 | 4.5 | Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00132-7 | ||
| 24997097 | 25245 | 3 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 501 | 7 | 3 | 7 | 4.0 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL1272137 | 25245 | 3 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 501 | 7 | 3 | 7 | 4.0 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 11797486 | 18815 | 1 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 3.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(O)Cc2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | ||
| CHEMBL1183448 | 18815 | 1 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 3.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(O)Cc2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | ||
| CHEMBL297557 | 18815 | 1 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 3.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(O)Cc2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | ||
| 10671037 | 138222 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL273660 | 138222 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL369085 | 138222 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| 21041264 | 88786 | 1 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 600 | 12 | 2 | 8 | 4.0 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2165339 | 88786 | 1 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 600 | 12 | 2 | 8 | 4.0 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| 10554539 | 108020 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 543 | 9 | 2 | 11 | 3.4 | CC(=O)OCCOc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm9608366 | ||
| CHEMBL296129 | 108020 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 543 | 9 | 2 | 11 | 3.4 | CC(=O)OCCOc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm9608366 | ||
| 10743872 | 103982 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 496 | 13 | 1 | 6 | 5.2 | CCCCN(CCCC)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL268432 | 103982 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 496 | 13 | 1 | 6 | 5.2 | CCCCN(CCCC)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL319719 | 218000 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 10625270 | 120152 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C)cc1 | 10.1021/jm990170q | ||
| CHEMBL331767 | 120152 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C)cc1 | 10.1021/jm990170q | ||
| 177236 | 8107 | 45 | None | -134 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(01)00660-6 | ||
| 3508 | 8107 | 45 | None | -134 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL23261 | 8107 | 45 | None | -134 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(01)00660-6 | ||
| DB04883 | 8107 | 45 | None | -134 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(01)00660-6 | ||
| 9853077 | 66401 | 0 | None | - | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 696 | 13 | 2 | 12 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL172030 | 66401 | 0 | None | - | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 696 | 13 | 2 | 12 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 10950843 | 209731 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cccc(OC)c1)O2 | 10.1021/jm010382z | ||
| CHEMBL62951 | 209731 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cccc(OC)c1)O2 | 10.1021/jm010382z | ||
| 10152810 | 21558 | 2 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 538 | 10 | 1 | 9 | 4.8 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1F | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1206706 | 21558 | 2 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 538 | 10 | 1 | 9 | 4.8 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1F | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL298725 | 21558 | 2 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 538 | 10 | 1 | 9 | 4.8 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1F | 10.1016/s0960-894x(98)00301-1 | ||
| 44311284 | 211024 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 635 | 12 | 2 | 10 | 6.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL71070 | 211024 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 635 | 12 | 2 | 10 | 6.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 44371532 | 58249 | 1 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL158239 | 58249 | 1 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| 44278161 | 106580 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 569 | 10 | 1 | 8 | 6.9 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL285380 | 106580 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 569 | 10 | 1 | 8 | 6.9 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL2370247 | 216592 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]([C@@H](C)CC)NC1=O | 10.1021/jm00015a003 | ||||
| 10790686 | 12022 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 474 | 5 | 1 | 8 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10635 | 12022 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 474 | 5 | 1 | 8 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCCO3)cc1 | 10.1021/jm9606507 | ||
| 10552007 | 13095 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 462 | 8 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c(OC)c(OC)c3)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10819 | 13095 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 462 | 8 | 1 | 7 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c(OC)c(OC)c3)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| 11058717 | 209595 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 412 | 8 | 1 | 6 | 4.6 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCC)cc21 | 10.1021/jm010382z | ||
| CHEMBL62348 | 209595 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 412 | 8 | 1 | 6 | 4.6 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCC)cc21 | 10.1021/jm010382z | ||
| 10951244 | 209732 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 504 | 9 | 1 | 7 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cc(OC)ccc1OC)O2 | 10.1021/jm010382z | ||
| CHEMBL62962 | 209732 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 504 | 9 | 1 | 7 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cc(OC)ccc1OC)O2 | 10.1021/jm010382z | ||
| 44294580 | 21407 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 502 | 8 | 1 | 7 | 5.8 | COc1ccc(C(=O)/C(Cc2ccc(OC(C)(C)C)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1205104 | 21407 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 502 | 8 | 1 | 7 | 5.8 | COc1ccc(C(=O)/C(Cc2ccc(OC(C)(C)C)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL52338 | 21407 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 502 | 8 | 1 | 7 | 5.8 | COc1ccc(C(=O)/C(Cc2ccc(OC(C)(C)C)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| 44266552 | 11285 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 | 10.1016/s0960-894x(97)10151-2 | ||
| CHEMBL10218 | 11285 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 | 10.1016/s0960-894x(97)10151-2 | ||
| 44310016 | 210618 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 489 | 6 | 1 | 9 | 4.8 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4nsnc4c3)c2cc1OC | 10.1016/s0960-894x(97)10151-2 | ||
| CHEMBL68557 | 210618 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 489 | 6 | 1 | 9 | 4.8 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4nsnc4c3)c2cc1OC | 10.1016/s0960-894x(97)10151-2 | ||
| 10195727 | 210706 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 487 | 7 | 1 | 8 | 5.6 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nsnc2c1 | 10.1016/s0960-894x(97)10151-2 | ||
| CHEMBL69150 | 210706 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 487 | 7 | 1 | 8 | 5.6 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nsnc2c1 | 10.1016/s0960-894x(97)10151-2 | ||
| 9809526 | 21631 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 614 | 12 | 2 | 11 | 3.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCS(=O)(=O)O)c2)cc1 | 10.1021/jm980504w | ||
| CHEMBL1207463 | 21631 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 614 | 12 | 2 | 11 | 3.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCS(=O)(=O)O)c2)cc1 | 10.1021/jm980504w | ||
| CHEMBL408055 | 21631 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 614 | 12 | 2 | 11 | 3.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCS(=O)(=O)O)c2)cc1 | 10.1021/jm980504w | ||
| 19010508 | 63119 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 501 | 9 | 1 | 7 | 5.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL16306 | 63119 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 501 | 9 | 1 | 7 | 5.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| 22616262 | 212318 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 366 | 3 | 1 | 4 | 3.7 | Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80980 | 212318 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 366 | 3 | 1 | 4 | 3.7 | Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 10505209 | 16089 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 490 | 6 | 1 | 9 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL11106 | 16089 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 490 | 6 | 1 | 9 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| 10767210 | 118092 | 0 | None | - | 0 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 484 | 12 | 1 | 4 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL326719 | 118092 | 0 | None | - | 0 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 484 | 12 | 1 | 4 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 10813007 | 120097 | 0 | None | - | 0 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 440 | 9 | 1 | 5 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL331577 | 120097 | 0 | None | - | 0 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 440 | 9 | 1 | 5 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 137655525 | 165770 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 525 | 7 | 3 | 9 | 3.5 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(O)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4096346 | 165770 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 525 | 7 | 3 | 9 | 3.5 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(O)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 71462247 | 88473 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2cnccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163723 | 88473 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 680 | 14 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2cnccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 71455063 | 88470 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 646 | 15 | 2 | 12 | 3.8 | CCCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| CHEMBL2163720 | 88470 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 646 | 15 | 2 | 12 | 3.8 | CCCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| 10304227 | 136786 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 603 | 10 | 2 | 13 | 4.2 | C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL367686 | 136786 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 603 | 10 | 2 | 13 | 4.2 | C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 9915028 | 16183 | 18 | None | -28183 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| CHEMBL111612 | 16183 | 18 | None | -28183 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| CHEMBL4761843 | 16183 | 18 | None | -28183 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| 10744041 | 104077 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 502 | 8 | 1 | 6 | 3.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)Cc2ccccc2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL269108 | 104077 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 502 | 8 | 1 | 6 | 3.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)Cc2ccccc2)cc1 | 10.1021/jm9505369 | ||
| 10140965 | 107949 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 485 | 7 | 3 | 9 | 3.0 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCO)OCO3)c1Cl | 10.1021/jm9608366 | ||
| CHEMBL295588 | 107949 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 485 | 7 | 3 | 9 | 3.0 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCO)OCO3)c1Cl | 10.1021/jm9608366 | ||
| 44371357 | 126517 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 515 | 8 | 1 | 8 | 5.2 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2cc(OC)c(OC)c(OC)c2)c2oc3ccccc3c21 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL347680 | 126517 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 515 | 8 | 1 | 8 | 5.2 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2cc(OC)c(OC)c(OC)c2)c2oc3ccccc3c21 | 10.1016/s0960-894x(99)00040-2 | ||
| 18995992 | 106614 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL28563 | 106614 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| 10994373 | 169233 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 474 | 5 | 1 | 7 | 5.0 | CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL416675 | 169233 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 474 | 5 | 1 | 7 | 5.0 | CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 11102844 | 210020 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 476 | 7 | 2 | 7 | 4.2 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)CO)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL64536 | 210020 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 476 | 7 | 2 | 7 | 4.2 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)CO)cc32)cc1 | 10.1021/jm010382z | ||
| 44314581 | 111654 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 591 | 11 | 6 | 5 | 2.8 | Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)NC(Cc1c[nH]cn1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL311134 | 111654 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 591 | 11 | 6 | 5 | 2.8 | Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)NC(Cc1c[nH]cn1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL2304014 | 216249 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(C#N)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O | 10.1021/jm9600914 | ||||
| 44311233 | 210888 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 630 | 12 | 2 | 13 | 4.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70303 | 210888 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 630 | 12 | 2 | 13 | 4.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL408141 | 219482 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | ||||
| CHEMBL436884 | 220469 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | ||||
| 44327726 | 214671 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 495 | 6 | 1 | 8 | 2.7 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc3c(cc2=O)CCC3)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL96644 | 214671 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 495 | 6 | 1 | 8 | 2.7 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc3c(cc2=O)CCC3)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| 18617393 | 212056 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 308 | 5 | 1 | 4 | 3.2 | CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2C)c1 | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL79066 | 212056 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 308 | 5 | 1 | 4 | 3.2 | CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2C)c1 | 10.1016/0960-894X(96)00441-6 | ||
| 10623877 | 15260 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 461 | 6 | 1 | 8 | 3.7 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10940 | 15260 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 461 | 6 | 1 | 8 | 3.7 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm9606507 | ||
| 10649122 | 16511 | 0 | None | - | 0 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 502 | 12 | 1 | 4 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL113400 | 16511 | 0 | None | - | 0 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 502 | 12 | 1 | 4 | 5.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 15340616 | 113611 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 420 | 4 | 1 | 6 | 3.3 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccc2c(c1)OCO2 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144602 | 113611 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 420 | 4 | 1 | 6 | 3.3 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccc2c(c1)OCO2 | 10.1016/s0960-894x(00)00232-8 | ||
| 10344511 | 66457 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 466 | 5 | 1 | 5 | 5.7 | Cc1cc(C)c(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL172248 | 66457 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 466 | 5 | 1 | 5 | 5.7 | Cc1cc(C)c(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| 10525281 | 189629 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 404 | 6 | 1 | 6 | 4.2 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 | 10.1021/jm9700068 | ||
| CHEMBL47915 | 189629 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 404 | 6 | 1 | 6 | 4.2 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 | 10.1021/jm9700068 | ||
| 12286 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| 6433095 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL109648 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| DB06677 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| 10342643 | 11929 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm9606507 | ||
| CHEMBL10588 | 11929 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 430 | 5 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C | 10.1021/jm9606507 | ||
| 71455061 | 88448 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 511 | 11 | 1 | 12 | 2.4 | COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncccn1 | 10.1021/jm3009103 | ||
| CHEMBL2163699 | 88448 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 511 | 11 | 1 | 12 | 2.4 | COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncccn1 | 10.1021/jm3009103 | ||
| 5310990 | 173609 | 11 | None | - | 1 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL428504 | 173609 | 11 | None | - | 1 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 10741025 | 188460 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 424 | 6 | 1 | 6 | 4.5 | Cc1cc(C)cc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 | 10.1021/jm9700068 | ||
| CHEMBL47765 | 188460 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 424 | 6 | 1 | 6 | 4.5 | Cc1cc(C)cc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 | 10.1021/jm9700068 | ||
| 44320782 | 113849 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 482 | 7 | 1 | 6 | 5.8 | COc1ccc(-c2nn(CC3CCCCC3)c(C(=O)O)c2Cc2cc3c(cc2Cl)OCO3)cc1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL315788 | 113849 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 482 | 7 | 1 | 6 | 5.8 | COc1ccc(-c2nn(CC3CCCCC3)c(C(=O)O)c2Cc2cc3c(cc2Cl)OCO3)cc1 | 10.1016/s0960-894x(00)00513-8 | ||
| 23445438 | 68273 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 470 | 6 | 1 | 7 | 4.1 | Cc1noc(NS(=O)(=O)c2sccc2CCc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL177070 | 68273 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 470 | 6 | 1 | 7 | 4.1 | Cc1noc(NS(=O)(=O)c2sccc2CCc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| 10815726 | 18220 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 516 | 8 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| CHEMBL1180348 | 18220 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 516 | 8 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| CHEMBL123146 | 18220 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 516 | 8 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| 10122442 | 137475 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 660 | 14 | 2 | 11 | 5.6 | CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL368383 | 137475 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 660 | 14 | 2 | 11 | 5.6 | CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 10602743 | 13929 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 550 | 9 | 1 | 10 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C | 10.1021/jm9606507 | ||
| CHEMBL10854 | 13929 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 550 | 9 | 1 | 10 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C | 10.1021/jm9606507 | ||
| 9933950 | 209605 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL62395 | 209605 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| 44295173 | 21405 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 554 | 10 | 1 | 9 | 5.3 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1Cl | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1205090 | 21405 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 554 | 10 | 1 | 9 | 5.3 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1Cl | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL51234 | 21405 | 0 | None | - | 0 | Pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 554 | 10 | 1 | 9 | 5.3 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1Cl | 10.1016/s0960-894x(98)00301-1 | ||
| 9868822 | 15363 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 459 | 6 | 1 | 7 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(N(C)C)cc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10948 | 15363 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 459 | 6 | 1 | 7 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(N(C)C)cc2)cc1 | 10.1021/jm9606507 | ||
| 9960931 | 114798 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 635 | 12 | 1 | 12 | 4.1 | CCOC(=O)CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | ||
| CHEMBL319452 | 114798 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 635 | 12 | 1 | 12 | 4.1 | CCOC(=O)CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | ||
| CHEMBL433349 | 220416 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 9868379 | 107560 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 450 | 5 | 1 | 6 | 5.6 | Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 | 10.1021/jm010382z | ||
| CHEMBL293012 | 107560 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 450 | 5 | 1 | 6 | 5.6 | Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 | 10.1021/jm010382z | ||
| 11733232 | 209643 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 460 | 7 | 1 | 6 | 5.2 | CCCOc1cccc2c1C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL62586 | 209643 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 460 | 7 | 1 | 6 | 5.2 | CCCOc1cccc2c1C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 11826062 | 209768 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 426 | 8 | 2 | 6 | 4.3 | CC(C)Oc1ccc2c(c1)C(CCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL63113 | 209768 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 426 | 8 | 2 | 6 | 4.3 | CC(C)Oc1ccc2c(c1)C(CCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 9868379 | 107560 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 450 | 5 | 1 | 6 | 5.6 | Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL293012 | 107560 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 450 | 5 | 1 | 6 | 5.6 | Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 | 10.1016/j.bmcl.2016.06.014 | ||
| 44295032 | 21562 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1cccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1206717 | 21562 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1cccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL299572 | 21562 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1cccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c1 | 10.1016/s0960-894x(98)00301-1 | ||
| 44294929 | 21566 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 460 | 8 | 1 | 7 | 4.7 | COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1206731 | 21566 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 460 | 8 | 1 | 7 | 4.7 | COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL301971 | 21566 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 460 | 8 | 1 | 7 | 4.7 | COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL317064 | 217976 | 15 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | ||||
| 11798999 | 214364 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 482 | 7 | 1 | 6 | 3.8 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)(C)C)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9495 | 214364 | 0 | None | - | 0 | Pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 482 | 7 | 1 | 6 | 3.8 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)(C)C)cc1 | 10.1021/jm9505369 | ||
| CHEMBL303185 | 217696 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00089a028 | ||||
| 10647021 | 13746 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1OC | 10.1021/jm9606507 | ||
| CHEMBL10846 | 13746 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1OC | 10.1021/jm9606507 | ||
| 10740614 | 105084 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1cccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c1 | 10.1021/jm9606507 | ||
| CHEMBL274857 | 105084 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1cccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c1 | 10.1021/jm9606507 | ||
| CHEMBL303185 | 217696 | 0 | None | - | 0 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm9600914 | ||||
| 443289 | 7498 | 47 | None | - | 3 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00237-N | ||||
| 997 | 7498 | 47 | None | - | 3 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00237-N | ||||
| CHEMBL314691 | 7498 | 47 | None | - | 3 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00237-N | ||||
| DB12054 | 7498 | 47 | None | - | 3 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00237-N | ||||
| CHEMBL336033 | 218353 | 1 | None | - | 0 | Pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | ||||
| 9806559 | 15922 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 515 | 13 | 1 | 6 | 3.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O | 10.1021/jm980217s | ||
| CHEMBL110053 | 15922 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 515 | 13 | 1 | 6 | 3.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O | 10.1021/jm980217s | ||
| 10224228 | 186391 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 424 | 6 | 1 | 6 | 4.5 | Cc1ccc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 | 10.1021/jm9700068 | ||
| CHEMBL47424 | 186391 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 424 | 6 | 1 | 6 | 4.5 | Cc1ccc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 | 10.1021/jm9700068 | ||
| 10601795 | 103747 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 510 | 10 | 1 | 6 | 4.4 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CC(C)C)CC(C)C)cc1 | 10.1021/jm9505369 | ||
| CHEMBL266354 | 103747 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 510 | 10 | 1 | 6 | 4.4 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CC(C)C)CC(C)C)cc1 | 10.1021/jm9505369 | ||
| 73669994 | 124408 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 429 | 9 | 1 | 7 | 4.7 | N#Cc1ccc(OCc2ccc3nonc3c2)cc1OC(CCC(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | ||
| CHEMBL3400996 | 124408 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 429 | 9 | 1 | 7 | 4.7 | N#Cc1ccc(OCc2ccc3nonc3c2)cc1OC(CCC(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | ||
| 10140871 | 66025 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 484 | 9 | 2 | 9 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)ncnc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL170342 | 66025 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 484 | 9 | 2 | 9 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)ncnc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| 10224745 | 119467 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 432 | 5 | 2 | 6 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL330425 | 119467 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 432 | 5 | 2 | 6 | 2.4 | Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 | 10.1016/j.bmcl.2016.06.014 | ||
| 10647373 | 103746 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 454 | 8 | 2 | 6 | 3.0 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(C)C)cc1 | 10.1021/jm9505369 | ||
| CHEMBL266337 | 103746 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 454 | 8 | 2 | 6 | 3.0 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(C)C)cc1 | 10.1021/jm9505369 | ||
| CHEMBL273391 | 217588 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | ||||
| CHEMBL273391 | 217588 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| 44284238 | 106903 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 490 | 8 | 3 | 7 | 4.2 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL287622 | 106903 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 490 | 8 | 3 | 7 | 4.2 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 9874557 | 136516 | 0 | None | - | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 667 | 15 | 2 | 10 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL367443 | 136516 | 0 | None | - | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 667 | 15 | 2 | 10 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 44311516 | 210897 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 678 | 12 | 2 | 12 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70339 | 210897 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 678 | 12 | 2 | 12 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 71453357 | 88457 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 707 | 12 | 1 | 12 | 5.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163708 | 88457 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 707 | 12 | 1 | 12 | 5.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 44328057 | 103669 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 986 | 26 | 9 | 9 | 4.9 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1cccnc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL265734 | 103669 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 986 | 26 | 9 | 9 | 4.9 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1cccnc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 11732966 | 209950 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 444 | 5 | 1 | 5 | 5.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL64244 | 209950 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 444 | 5 | 1 | 5 | 5.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| 44279309 | 168596 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 3 | 2 | 3 | 4.5 | Cc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL414408 | 168596 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 3 | 2 | 3 | 4.5 | Cc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 | 10.1016/0960-894X(95)00230-Q | ||
| 44334097 | 116846 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 447 | 7 | 2 | 6 | 3.7 | COc1ccc([C@@H]2c3nc(CCCO)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL323561 | 116846 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 447 | 7 | 2 | 6 | 3.7 | COc1ccc([C@@H]2c3nc(CCCO)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| 44371460 | 56304 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 469 | 5 | 1 | 7 | 4.9 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2oc3ccccc3c21 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL156539 | 56304 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 469 | 5 | 1 | 7 | 4.9 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2oc3ccccc3c21 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL319537 | 217998 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 10815005 | 16520 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 492 | 6 | 1 | 6 | 5.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(-c3ccccc3)cc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL11345 | 16520 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 492 | 6 | 1 | 6 | 5.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(-c3ccccc3)cc2)cc1 | 10.1021/jm9606507 | ||
| 54587165 | 67083 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 675 | 15 | 5 | 4 | 5.9 | CCCCCC[C@@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL1744023 | 67083 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 675 | 15 | 5 | 4 | 5.9 | CCCCCC[C@@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL315047 | 217965 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| 44295114 | 21652 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 556 | 11 | 1 | 9 | 5.3 | COc1cc(C/C(C(=O)c2ccc(OC(F)F)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1207717 | 21652 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 556 | 11 | 1 | 9 | 5.3 | COc1cc(C/C(C(=O)c2ccc(OC(F)F)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL433090 | 21652 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 556 | 11 | 1 | 9 | 5.3 | COc1cc(C/C(C(=O)c2ccc(OC(F)F)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| 10768294 | 21360 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 520 | 10 | 1 | 8 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1C | 10.1021/jm9606507 | ||
| CHEMBL10922 | 21360 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 520 | 10 | 1 | 8 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1C | 10.1021/jm9606507 | ||
| CHEMBL1204674 | 21360 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 520 | 10 | 1 | 8 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1C | 10.1021/jm9606507 | ||
| 19010490 | 60309 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 648 | 13 | 1 | 9 | 6.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)C(C)C)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL16018 | 60309 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 648 | 13 | 1 | 9 | 6.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)C(C)C)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| 44368480 | 51382 | 0 | None | - | 0 | Pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 495 | 13 | 1 | 7 | 4.4 | COc1ccc(CC(C(=O)O)N(Cc2ccc(OC)cc2)Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL152034 | 51382 | 0 | None | - | 0 | Pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 495 | 13 | 1 | 7 | 4.4 | COc1ccc(CC(C(=O)O)N(Cc2ccc(OC)cc2)Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| 10837347 | 15641 | 0 | None | - | 0 | Pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 452 | 8 | 1 | 5 | 3.3 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL109736 | 15641 | 0 | None | - | 0 | Pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 452 | 8 | 1 | 5 | 3.3 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 10841134 | 67222 | 0 | None | - | 0 | Pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 589 | 10 | 4 | 6 | 5.3 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC23CC4CC(CC(C4)C2)C3)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL175277 | 67222 | 0 | None | - | 0 | Pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 589 | 10 | 4 | 6 | 5.3 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC23CC4CC(CC(C4)C2)C3)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL414165 | 219894 | 0 | None | - | 0 | Pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](c2cccs2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | ||||
| 159594 | 7310 | 45 | None | - | 3 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm9505369 | ||
| 3487 | 7310 | 45 | None | - | 3 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm9505369 | ||
| CHEMBL9194 | 7310 | 45 | None | - | 3 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm9505369 | ||
| DB06199 | 7310 | 45 | None | - | 3 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm9505369 | ||
| 44439111 | 103951 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 979 | 31 | 2 | 15 | 7.0 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 | 10.1016/j.bmcl.2006.10.009 | ||
| CHEMBL268201 | 103951 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 979 | 31 | 2 | 15 | 7.0 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 | 10.1016/j.bmcl.2006.10.009 | ||
| 10622380 | 108232 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 426 | 7 | 1 | 7 | 3.9 | COc1cccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 | 10.1021/jm9700068 | ||
| CHEMBL297679 | 108232 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 426 | 7 | 1 | 7 | 3.9 | COc1cccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 | 10.1021/jm9700068 | ||
| 21041372 | 88475 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 687 | 14 | 2 | 12 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(N2CCOCC2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163725 | 88475 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 687 | 14 | 2 | 12 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(N2CCOCC2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 71462246 | 88466 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 604 | 12 | 2 | 12 | 2.6 | CNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| CHEMBL2163717 | 88466 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 604 | 12 | 2 | 12 | 2.6 | CNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| 3951 | 7179 | 86 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 4337 | 7179 | 86 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 6918493 | 7179 | 86 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL1111 | 7179 | 86 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | ||
| DB06403 | 7179 | 86 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 44384766 | 66439 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 532 | 10 | 1 | 10 | 4.1 | C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL172184 | 66439 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 532 | 10 | 1 | 10 | 4.1 | C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 10576888 | 177624 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 485 | 6 | 3 | 7 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2C(=O)O)c1Br | 10.1021/jm9608366 | ||
| CHEMBL44539 | 177624 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 485 | 6 | 3 | 7 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2C(=O)O)c1Br | 10.1021/jm9608366 | ||
| 10211781 | 136519 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL367453 | 136519 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| 73669820 | 124406 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 462 | 10 | 1 | 7 | 5.5 | CC(=O)c1ccc(OCc2ccc3nsnc3c2)cc1OC(CCC(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | ||
| CHEMBL3400989 | 124406 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 462 | 10 | 1 | 7 | 5.5 | CC(=O)c1ccc(OCc2ccc3nsnc3c2)cc1OC(CCC(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | ||
| 10697883 | 18011 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 548 | 8 | 3 | 10 | 2.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CNS(C)(=O)=O)OCO3)c1Cl | 10.1021/jm9608366 | ||
| CHEMBL1178885 | 18011 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 548 | 8 | 3 | 10 | 2.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CNS(C)(=O)=O)OCO3)c1Cl | 10.1021/jm9608366 | ||
| CHEMBL47828 | 18011 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 548 | 8 | 3 | 10 | 2.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CNS(C)(=O)=O)OCO3)c1Cl | 10.1021/jm9608366 | ||
| 137639474 | 163676 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 607 | 10 | 2 | 9 | 5.4 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4072165 | 163676 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 607 | 10 | 2 | 9 | 5.4 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 52949155 | 25183 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 557 | 10 | 2 | 7 | 5.4 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| CHEMBL1271640 | 25183 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 557 | 10 | 2 | 7 | 5.4 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| 10122495 | 37644 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 665 | 12 | 1 | 10 | 6.4 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOCc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL139734 | 37644 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 665 | 12 | 1 | 10 | 6.4 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOCc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | ||
| 9870117 | 201665 | 0 | None | - | 0 | Pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 488 | 10 | 1 | 7 | 5.5 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL54057 | 201665 | 0 | None | - | 0 | Pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 488 | 10 | 1 | 7 | 5.5 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 9870117 | 201665 | 0 | None | - | 0 | Pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 488 | 10 | 1 | 7 | 5.5 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL54057 | 201665 | 0 | None | - | 0 | Pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 488 | 10 | 1 | 7 | 5.5 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 | 10.1016/j.bmcl.2016.06.014 | ||
| 9831249 | 66471 | 0 | None | - | 2 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 672 | 14 | 2 | 10 | 6.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL172297 | 66471 | 0 | None | - | 2 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 672 | 14 | 2 | 10 | 6.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 10720982 | 134595 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 530 | 9 | 2 | 6 | 4.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 | 10.1021/jm990171i | ||
| CHEMBL121647 | 134595 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 530 | 9 | 2 | 6 | 4.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 | 10.1021/jm990171i | ||
| CHEMBL366441 | 134595 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 530 | 9 | 2 | 6 | 4.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 | 10.1021/jm990171i | ||
| 44314889 | 110519 | 0 | None | - | 0 | Pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 633 | 12 | 5 | 4 | 4.7 | CCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL308815 | 110519 | 0 | None | - | 0 | Pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 633 | 12 | 5 | 4 | 4.7 | CCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 9808545 | 18224 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 588 | 11 | 2 | 7 | 5.2 | COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 | 10.1021/jm990171i | ||
| CHEMBL1180353 | 18224 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 588 | 11 | 2 | 7 | 5.2 | COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 | 10.1021/jm990171i | ||
| CHEMBL123408 | 18224 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 588 | 11 | 2 | 7 | 5.2 | COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 | 10.1021/jm990171i | ||
| 44314579 | 109694 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL306123 | 109694 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1021/jm9600914 | ||
| 44283270 | 174660 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| CHEMBL431124 | 174660 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| CHEMBL414047 | 219884 | 0 | None | - | 0 | Bovine | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]cn2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(97)00296-5 | ||||
| 44314750 | 172431 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 647 | 13 | 5 | 4 | 5.1 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL424422 | 172431 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 647 | 13 | 5 | 4 | 5.1 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 44283419 | 107093 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 647 | 13 | 5 | 4 | 5.1 | CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| CHEMBL289349 | 107093 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 647 | 13 | 5 | 4 | 5.1 | CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| 10603546 | 117224 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCC)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL324639 | 117224 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 592 | 15 | 1 | 7 | 5.0 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCC)c(F)c1 | 10.1021/jm970101g | ||
| 10625694 | 18218 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 516 | 9 | 2 | 6 | 4.5 | CCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| CHEMBL1180344 | 18218 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 516 | 9 | 2 | 6 | 4.5 | CCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| CHEMBL123107 | 18218 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 516 | 9 | 2 | 6 | 4.5 | CCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| 11123269 | 213079 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 452 | 6 | 1 | 5 | 5.8 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL87070 | 213079 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 452 | 6 | 1 | 5 | 5.8 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| 44314664 | 211475 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 615 | 12 | 5 | 4 | 5.1 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CCCC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL74000 | 211475 | 0 | None | - | 0 | Pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 615 | 12 | 5 | 4 | 5.1 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CCCC1)C(=O)O | 10.1021/jm9600914 | ||
| 10555516 | 16013 | 0 | None | - | 0 | Pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 598 | 12 | 1 | 7 | 4.6 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)Cc1ccccc1 | 10.1021/jm970101g | ||
| CHEMBL110700 | 16013 | 0 | None | - | 0 | Pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 598 | 12 | 1 | 7 | 4.6 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)Cc1ccccc1 | 10.1021/jm970101g | ||
| 44314904 | 109924 | 0 | None | - | 0 | Pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 585 | 12 | 5 | 5 | 3.6 | CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL307936 | 109924 | 0 | None | - | 0 | Pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 585 | 12 | 5 | 5 | 3.6 | CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| 44314905 | 211826 | 0 | None | - | 0 | Pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 567 | 12 | 5 | 4 | 4.0 | CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL77083 | 211826 | 0 | None | - | 0 | Pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 567 | 12 | 5 | 4 | 4.0 | CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| 10649119 | 18210 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 502 | 8 | 2 | 6 | 4.1 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL1180318 | 18210 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 502 | 8 | 2 | 6 | 4.1 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL121761 | 18210 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 502 | 8 | 2 | 6 | 4.1 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL317099 | 217977 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 44298382 | 201891 | 0 | None | - | 0 | Pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 502 | 11 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCC=O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL54998 | 201891 | 0 | None | - | 0 | Pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 502 | 11 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCC=O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 10792316 | 175261 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 8 | 2 | 6 | 5.3 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C(C)C)cc1 | 10.1021/jm990170q | ||
| CHEMBL435185 | 175261 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 8 | 2 | 6 | 5.3 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C(C)C)cc1 | 10.1021/jm990170q | ||
| CHEMBL313984 | 217902 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| 56671734 | 70103 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 937 | 26 | 9 | 9 | 3.6 | CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)NCC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC | 10.1021/jm970161m | ||
| CHEMBL1793932 | 70103 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 937 | 26 | 9 | 9 | 3.6 | CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)NCC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC | 10.1021/jm970161m | ||
| 44284236 | 129101 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 504 | 9 | 3 | 7 | 4.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCCO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL35984 | 129101 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 504 | 9 | 3 | 7 | 4.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCCO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 21462927 | 127020 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 500 | 7 | 1 | 8 | 5.1 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc([N+](=O)[O-])ccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL352241 | 127020 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 500 | 7 | 1 | 8 | 5.1 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc([N+](=O)[O-])ccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| 9825494 | 209389 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL61211 | 209389 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| 10896413 | 107383 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 504 | 9 | 1 | 7 | 5.4 | COc1ccc(CCOC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL291841 | 107383 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 504 | 9 | 1 | 7 | 5.4 | COc1ccc(CCOC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| 11755275 | 206788 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 489 | 9 | 1 | 7 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC | 10.1016/S0960-894X(97)00319-3 | ||
| CHEMBL59537 | 206788 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 489 | 9 | 1 | 7 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC | 10.1016/S0960-894X(97)00319-3 | ||
| 10627272 | 210835 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 592 | 12 | 1 | 11 | 4.2 | COC(=O)CCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | ||
| CHEMBL69986 | 210835 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 592 | 12 | 1 | 11 | 4.2 | COC(=O)CCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | ||
| 44311527 | 210902 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 675 | 12 | 2 | 11 | 7.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70365 | 210902 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 675 | 12 | 2 | 11 | 7.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 44327868 | 118221 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 906 | 24 | 9 | 8 | 3.9 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC12CC3CC(CC(C3)C1)C2)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL327523 | 118221 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 906 | 24 | 9 | 8 | 3.9 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC12CC3CC(CC(C3)C1)C2)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 10791694 | 104976 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2OC)cc1 | 10.1021/jm9606507 | ||
| CHEMBL274175 | 104976 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2OC)cc1 | 10.1021/jm9606507 | ||
| 9934580 | 169709 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 474 | 6 | 1 | 8 | 3.6 | COC(=O)c1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL417428 | 169709 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 474 | 6 | 1 | 8 | 3.6 | COC(=O)c1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | ||
| 10765057 | 169939 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 430 | 4 | 1 | 7 | 3.5 | O=C1OC(O)(c2ccc3c(c2)OCO3)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm9606507 | ||
| CHEMBL417978 | 169939 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 430 | 4 | 1 | 7 | 3.5 | O=C1OC(O)(c2ccc3c(c2)OCO3)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm9606507 | ||
| CHEMBL5272983 | 200522 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 439 | 7 | 2 | 6 | 3.3 | O=S(=O)(Nc1ncnc(OCCO)c1-c1ccccc1)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.0c01093 | ||
| 19735343 | 182830 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 4.0 | O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4590568 | 182830 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 4.0 | O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL86814 | 222671 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| CHEMBL1791279 | 215698 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00152-J | ||||
| 44383753 | 66840 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 466 | 5 | 1 | 5 | 5.7 | Cc1cc(C)c(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL173761 | 66840 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 466 | 5 | 1 | 5 | 5.7 | Cc1cc(C)c(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| 44327661 | 171369 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 483 | 5 | 1 | 8 | 2.7 | Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL421563 | 171369 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 483 | 5 | 1 | 8 | 2.7 | Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| 44316515 | 211783 | 2 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 360 | 4 | 1 | 5 | 2.9 | COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL76779 | 211783 | 2 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 360 | 4 | 1 | 5 | 2.9 | COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 18617288 | 211925 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 316 | 3 | 1 | 4 | 2.5 | Cc1noc(NS(=O)(=O)c2ccccc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL78080 | 211925 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 316 | 3 | 1 | 4 | 2.5 | Cc1noc(NS(=O)(=O)c2ccccc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 11800804 | 168615 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 550 | 10 | 4 | 5 | 4.7 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| CHEMBL414605 | 168615 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 550 | 10 | 4 | 5 | 4.7 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.5b01781 | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.5b01781 | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.5b01781 | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.5b01781 | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/acs.jmedchem.5b01781 | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm3009103 | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm3009103 | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm3009103 | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm3009103 | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm3009103 | ||
| 10122033 | 88452 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 631 | 15 | 1 | 13 | 4.0 | COc1cnc(OCCOc2nc(-c3ncccn3)nc(NS(=O)(=O)CCc3ccccc3)c2Oc2ccccc2OC)nc1 | 10.1021/jm3009103 | ||
| CHEMBL2163703 | 88452 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 631 | 15 | 1 | 13 | 4.0 | COc1cnc(OCCOc2nc(-c3ncccn3)nc(NS(=O)(=O)CCc3ccccc3)c2Oc2ccccc2OC)nc1 | 10.1021/jm3009103 | ||
| 58688005 | 181739 | 1 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 540 | 11 | 2 | 9 | 3.1 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4565926 | 181739 | 1 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 540 | 11 | 2 | 9 | 3.1 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 10144372 | 172833 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 562 | 10 | 2 | 11 | 3.4 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL425682 | 172833 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 562 | 10 | 2 | 11 | 3.4 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| 22467229 | 105733 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 519 | 7 | 2 | 7 | 4.1 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CN)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL279703 | 105733 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 519 | 7 | 2 | 7 | 4.1 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CN)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| 44320338 | 113751 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 490 | 7 | 2 | 6 | 5.0 | O=C(O)c1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL315087 | 113751 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 490 | 7 | 2 | 6 | 5.0 | O=C(O)c1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc1 | 10.1016/s0960-894x(00)00513-8 | ||
| 10281192 | 67851 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 11 | 2 | 10 | 4.2 | C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL176482 | 67851 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 11 | 2 | 10 | 4.2 | C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 10211543 | 138163 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 640 | 13 | 2 | 12 | 3.5 | CCCCNC(=O)OCC#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL368989 | 138163 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 640 | 13 | 2 | 12 | 3.5 | CCCCNC(=O)OCC#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 71462245 | 88441 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 588 | 13 | 2 | 10 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cc(OC)ccc1Cl | 10.1021/jm3009103 | ||
| CHEMBL2163692 | 88441 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 588 | 13 | 2 | 10 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cc(OC)ccc1Cl | 10.1021/jm3009103 | ||
| 44177614 | 136429 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 547 | 10 | 1 | 9 | 5.4 | C=CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL367339 | 136429 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 547 | 10 | 1 | 9 | 5.4 | C=CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 10479787 | 66389 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 468 | 6 | 1 | 5 | 5.3 | Cc1cc(C)c(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL171972 | 66389 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 468 | 6 | 1 | 5 | 5.3 | Cc1cc(C)c(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| 151174 | 209499 | 45 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 605 | 12 | 3 | 13 | 3.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL61780 | 209499 | 45 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 605 | 12 | 3 | 13 | 3.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | ||
| 44334130 | 11281 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 458 | 5 | 1 | 6 | 4.4 | COc1ccc([C@@H]2c3nc(N4CCCC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL102173 | 11281 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 458 | 5 | 1 | 6 | 4.4 | COc1ccc([C@@H]2c3nc(N4CCCC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| 10745564 | 12997 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 566 | 11 | 1 | 7 | 4.4 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccccc1 | 10.1021/jm970101g | ||
| CHEMBL108142 | 12997 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 566 | 11 | 1 | 7 | 4.4 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccccc1 | 10.1021/jm970101g | ||
| CHEMBL263295 | 217344 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | ||||
| 44304492 | 103335 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 949 | 23 | 9 | 8 | 4.3 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL262993 | 103335 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 949 | 23 | 9 | 8 | 4.3 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 18738880 | 174953 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 8 | 2 | 7 | 4.5 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)NC)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL433221 | 174953 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 8 | 2 | 7 | 4.5 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)NC)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| 21041283 | 179926 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 552 | 13 | 2 | 9 | 3.2 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4521348 | 179926 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 552 | 13 | 2 | 9 | 3.2 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 10960638 | 107845 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 414 | 4 | 1 | 4 | 5.6 | CC(C)c1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL294793 | 107845 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 414 | 4 | 1 | 4 | 5.6 | CC(C)c1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 | 10.1021/jm010382z | ||
| 44279371 | 106700 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 466 | 3 | 2 | 3 | 5.5 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cc(Cl)cc(Cl)c3)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL286214 | 106700 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 466 | 3 | 2 | 3 | 5.5 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cc(Cl)cc(Cl)c3)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| 10814743 | 186150 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 484 | 6 | 1 | 9 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C2(Cc3ccc4c(c3)OCO4)OCCO2)c1Cl | 10.1021/jm9700068 | ||
| CHEMBL47383 | 186150 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 484 | 6 | 1 | 9 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C2(Cc3ccc4c(c3)OCO4)OCCO2)c1Cl | 10.1021/jm9700068 | ||
| 10555424 | 210815 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 592 | 13 | 2 | 10 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCCC(=O)O)c2)cc1 | 10.1021/jm980504w | ||
| CHEMBL69832 | 210815 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 592 | 13 | 2 | 10 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCCC(=O)O)c2)cc1 | 10.1021/jm980504w | ||
| 44266568 | 104873 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 493 | 7 | 1 | 6 | 6.3 | COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OCc4ccccc4)cc23)cc1 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL273410 | 104873 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 493 | 7 | 1 | 6 | 6.3 | COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OCc4ccccc4)cc23)cc1 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL133257 | 215494 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | ||||
| 44383537 | 66023 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 388 | 4 | 2 | 5 | 3.4 | C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 | 10.1016/s0960-894x(00)00136-0 | ||
| CHEMBL170335 | 66023 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 388 | 4 | 2 | 5 | 3.4 | C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 | 10.1016/s0960-894x(00)00136-0 | ||
| 10648937 | 214085 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9334 | 214085 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44385412 | 138156 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 711 | 14 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(Cc2ccc3c(c2)OCO3)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL368945 | 138156 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 711 | 14 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(Cc2ccc3c(c2)OCO3)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 23445358 | 118340 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 4.6 | Cc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL328089 | 118340 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 4.6 | Cc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/S0960-894X(96)00496-9 | ||
| 44352079 | 123319 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 494 | 11 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 | 10.1021/jm010237l | ||
| CHEMBL336272 | 123319 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 494 | 11 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 | 10.1021/jm010237l | ||
| 137649809 | 164166 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 583 | 10 | 2 | 7 | 5.9 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4078297 | 164166 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 583 | 10 | 2 | 7 | 5.9 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 23548253 | 88451 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 679 | 14 | 1 | 12 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL2163702 | 88451 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 679 | 14 | 1 | 12 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 23548253 | 88451 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 679 | 14 | 1 | 12 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163702 | 88451 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 679 | 14 | 1 | 12 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 76330201 | 92124 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 526 | 6 | 1 | 7 | 4.5 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(Cl)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261363 | 92124 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 526 | 6 | 1 | 7 | 4.5 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(Cl)ccc12 | 10.1007/s00044-004-0021-y | ||
| 44214320 | 92125 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 510 | 6 | 1 | 7 | 4.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(F)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261364 | 92125 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 510 | 6 | 1 | 7 | 4.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(F)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2304017 | 216252 | 0 | None | - | 0 | Pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(C#N)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O | 10.1021/jm9600914 | ||||
| 11059576 | 210072 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 460 | 7 | 1 | 6 | 5.2 | CCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL64726 | 210072 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 460 | 7 | 1 | 6 | 5.2 | CCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 44295097 | 21535 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 604 | 13 | 1 | 9 | 7.0 | COc1ccc(C(=O)/C(Cc2cc(OC(C)C)c(OC(C)C)c(OC(C)C)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1206461 | 21535 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 604 | 13 | 1 | 9 | 7.0 | COc1ccc(C(=O)/C(Cc2cc(OC(C)C)c(OC(C)C)c(OC(C)C)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL276362 | 21535 | 0 | None | - | 0 | Pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 604 | 13 | 1 | 9 | 7.0 | COc1ccc(C(=O)/C(Cc2cc(OC(C)C)c(OC(C)C)c(OC(C)C)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| 11827880 | 16998 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 565 | 10 | 1 | 9 | 5.5 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | ||
| CHEMBL116046 | 16998 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 565 | 10 | 1 | 9 | 5.5 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | ||
| CHEMBL177979 | 16998 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 565 | 10 | 1 | 9 | 5.5 | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | ||
| 10552548 | 105298 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2OC)cc1 | 10.1021/jm9606507 | ||
| CHEMBL276252 | 105298 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2OC)cc1 | 10.1021/jm9606507 | ||
| 11145841 | 107732 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 528 | 9 | 1 | 6 | 6.9 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC3CCCC3)cc1)O2 | 10.1021/jm010382z | ||
| CHEMBL294127 | 107732 | 0 | None | - | 0 | Pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 528 | 9 | 1 | 6 | 6.9 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC3CCCC3)cc1)O2 | 10.1021/jm010382z | ||
| 18738879 | 97008 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 548 | 8 | 2 | 7 | 4.8 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL23833 | 97008 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 548 | 8 | 2 | 7 | 4.8 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| 15340617 | 106013 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 1 | 7 | 3.7 | COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCC(=O)O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL281677 | 106013 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 1 | 7 | 3.7 | COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCC(=O)O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 18617379 | 212003 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 364 | 3 | 1 | 4 | 3.5 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL78669 | 212003 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 364 | 3 | 1 | 4 | 3.5 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 44276948 | 113613 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 396 | 5 | 1 | 3 | 4.5 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)cc3)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144604 | 113613 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 396 | 5 | 1 | 3 | 4.5 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)cc3)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 9845967 | 17865 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10801 | 17865 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL1178000 | 17865 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL51530 | 17865 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| 44385941 | 137454 | 0 | None | - | 0 | Pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 550 | 10 | 5 | 5 | 4.6 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC(C)C2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL368286 | 137454 | 0 | None | - | 0 | Pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 550 | 10 | 5 | 5 | 4.6 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC(C)C2)nc1C(=O)O | 10.1021/jm950592+ | ||
| 44266532 | 11273 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 401 | 3 | 1 | 6 | 4.5 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL10211 | 11273 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 401 | 3 | 1 | 6 | 4.5 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1-c1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| 10282163 | 67187 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 599 | 11 | 2 | 12 | 3.9 | C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL175057 | 67187 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 599 | 11 | 2 | 12 | 3.9 | C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 9932004 | 104953 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCC2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL273948 | 104953 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCC2)cc1 | 10.1021/jm9606507 | ||
| 44458604 | 105389 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 559 | 6 | 2 | 7 | 3.7 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL276982 | 105389 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 559 | 6 | 2 | 7 | 3.7 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| 44386161 | 68050 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 573 | 9 | 1 | 9 | 5.6 | CCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL176650 | 68050 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 573 | 9 | 1 | 9 | 5.6 | CCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL2304008 | 216243 | 0 | None | - | 0 | Pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O | 10.1021/jm9600914 | ||||
| 44284391 | 146079 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 532 | 9 | 3 | 7 | 5.3 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCC(C)(C)O)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL37920 | 146079 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 532 | 9 | 3 | 7 | 5.3 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCC(C)(C)O)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 18995991 | 107076 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 537 | 8 | 1 | 10 | 5.0 | COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL28920 | 107076 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 537 | 8 | 1 | 10 | 5.0 | COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC | 10.1016/0960-894X(96)00232-6 | ||
| 44279127 | 106264 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 432 | 3 | 2 | 3 | 4.8 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL283200 | 106264 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 432 | 3 | 2 | 3 | 4.8 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| 19010493 | 105132 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 543 | 11 | 1 | 7 | 6.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL275179 | 105132 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 543 | 11 | 1 | 7 | 6.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| 11048815 | 109092 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 460 | 7 | 1 | 6 | 5.2 | CCCOc1ccc2c(c1)OC(c1ccc3c(c1)OCO3)C(C(=O)O)=C2c1ccc(OC)cc1 | 10.1021/jm010382z | ||
| CHEMBL303531 | 109092 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 460 | 7 | 1 | 6 | 5.2 | CCCOc1ccc2c(c1)OC(c1ccc3c(c1)OCO3)C(C(=O)O)=C2c1ccc(OC)cc1 | 10.1021/jm010382z | ||
| 10862228 | 209740 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 398 | 7 | 1 | 6 | 4.2 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC)cc21 | 10.1021/jm010382z | ||
| CHEMBL63000 | 209740 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 398 | 7 | 1 | 6 | 4.2 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC)cc21 | 10.1021/jm010382z | ||
| 10722371 | 109005 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 605 | 11 | 1 | 11 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN3CCOCC3)c2)cc1 | 10.1021/jm980504w | ||
| CHEMBL302974 | 109005 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 605 | 11 | 1 | 11 | 3.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN3CCOCC3)c2)cc1 | 10.1021/jm980504w | ||
| 44316768 | 212022 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 358 | 4 | 1 | 4 | 3.4 | CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL78830 | 212022 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 358 | 4 | 1 | 4 | 3.4 | CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 443289 | 7498 | 47 | None | - | 3 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| 997 | 7498 | 47 | None | - | 3 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| CHEMBL314691 | 7498 | 47 | None | - | 3 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| DB12054 | 7498 | 47 | None | - | 3 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| 10478562 | 138576 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 442 | 6 | 1 | 6 | 4.5 | Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL369359 | 138576 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 442 | 6 | 1 | 6 | 4.5 | Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00132-7 | ||
| 10717279 | 103822 | 0 | None | - | 0 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 425 | 9 | 1 | 5 | 4.8 | CCCCCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL266996 | 103822 | 0 | None | - | 0 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 425 | 9 | 1 | 5 | 4.8 | CCCCCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 10122675 | 105248 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 682 | 12 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL275897 | 105248 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 682 | 12 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| 10742024 | 103718 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 446 | 7 | 1 | 6 | 3.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCc2ccccn2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL266143 | 103718 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 446 | 7 | 1 | 6 | 3.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCc2ccccn2)cc1 | 10.1021/jm9505369 | ||
| 135884434 | 137343 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 628 | 10 | 2 | 12 | 5.2 | C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL368117 | 137343 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 628 | 10 | 2 | 12 | 5.2 | C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 9810571 | 68160 | 0 | None | - | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 731 | 18 | 2 | 13 | 5.0 | CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL176997 | 68160 | 0 | None | - | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 731 | 18 | 2 | 13 | 5.0 | CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 18184194 | 137340 | 0 | None | - | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 712 | 15 | 2 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL368107 | 137340 | 0 | None | - | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 712 | 15 | 2 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 44368819 | 175671 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 1637 | 31 | 19 | 20 | 1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | ||
| 77282140 | 175671 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 1637 | 31 | 19 | 20 | 1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | ||
| CHEMBL438380 | 175671 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 1637 | 31 | 19 | 20 | 1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | ||
| 10815823 | 16569 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 520 | 8 | 1 | 9 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C | 10.1021/jm9606507 | ||
| CHEMBL11369 | 16569 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 520 | 8 | 1 | 9 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C | 10.1021/jm9606507 | ||
| 44298304 | 108332 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 10 | 2 | 7 | 4.7 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(N)=O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL298395 | 108332 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 10 | 2 | 7 | 4.7 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(N)=O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 44298409 | 201777 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 490 | 10 | 2 | 7 | 5.2 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCO)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL54770 | 201777 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 490 | 10 | 2 | 7 | 5.2 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCO)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL2304018 | 216253 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Cl)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O | 10.1021/jm9600914 | ||||
| 76319370 | 92131 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 564 | 8 | 1 | 9 | 4.0 | CCOC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261602 | 92131 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 564 | 8 | 1 | 9 | 4.0 | CCOC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 | 10.1007/s00044-004-0021-y | ||
| 10886132 | 16581 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 549 | 10 | 1 | 9 | 4.8 | COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | ||
| CHEMBL113757 | 16581 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 549 | 10 | 1 | 9 | 4.8 | COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | ||
| CHEMBL368796 | 16581 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 549 | 10 | 1 | 9 | 4.8 | COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 | 10.1021/jm0102304 | ||
| 10440821 | 214317 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 918 | 24 | 9 | 8 | 4.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c(C)c(C)c(C)c(C)c1C)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL94689 | 214317 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 918 | 24 | 9 | 8 | 4.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c(C)c(C)c(C)c(C)c1C)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 44279351 | 106720 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 412 | 3 | 2 | 3 | 4.5 | Cc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL286333 | 106720 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 412 | 3 | 2 | 3 | 4.5 | Cc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 | 10.1016/0960-894X(95)00230-Q | ||
| 44279129 | 113772 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 428 | 4 | 2 | 4 | 4.2 | COc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL31524 | 113772 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 428 | 4 | 2 | 4 | 4.2 | COc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 | 10.1016/0960-894X(95)00230-Q | ||
| 22998446 | 113409 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 398 | 4 | 1 | 5 | 4.3 | Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL314320 | 113409 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 398 | 4 | 1 | 5 | 4.3 | Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| 44277263 | 113614 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc4c(cc3Cl)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144605 | 113614 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc4c(cc3Cl)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 10744085 | 109647 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 503 | 9 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN(C)C)c2)cc1 | 10.1021/jm980504w | ||
| CHEMBL305777 | 109647 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 503 | 9 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN(C)C)c2)cc1 | 10.1021/jm980504w | ||
| 44327727 | 174976 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 503 | 6 | 1 | 8 | 3.0 | Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL433373 | 174976 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 503 | 6 | 1 | 8 | 3.0 | Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| 44386536 | 137491 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 549 | 10 | 4 | 6 | 4.9 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2F)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL368461 | 137491 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 549 | 10 | 4 | 6 | 4.9 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2F)nc1C(=O)O | 10.1021/jm950592+ | ||
| 44266655 | 11815 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 445 | 5 | 1 | 7 | 4.5 | COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL10523 | 11815 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 445 | 5 | 1 | 7 | 4.5 | COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| 18617363 | 171339 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 384 | 3 | 1 | 4 | 3.9 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL421523 | 171339 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 384 | 3 | 1 | 4 | 3.9 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 5344 | 180252 | 101 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 267 | 3 | 2 | 5 | 1.7 | Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL453 | 180252 | 101 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 267 | 3 | 2 | 5 | 1.7 | Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 15453210 | 212025 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 376 | 5 | 1 | 6 | 2.6 | COc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1OC | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL78853 | 212025 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 376 | 5 | 1 | 6 | 2.6 | COc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1OC | 10.1016/0960-894X(96)00441-6 | ||
| 44276596 | 113619 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 458 | 8 | 1 | 6 | 4.2 | COc1ccc(Cc2[nH]n(Cc3cccc(OC)c3)c(=O)c2Cc2ccc3c(c2)OCO3)cc1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144728 | 113619 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 458 | 8 | 1 | 6 | 4.2 | COc1ccc(Cc2[nH]n(Cc3cccc(OC)c3)c(=O)c2Cc2ccc3c(c2)OCO3)cc1 | 10.1016/s0960-894x(00)00232-8 | ||
| 44276907 | 113632 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 376 | 4 | 1 | 4 | 3.6 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144845 | 113632 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 376 | 4 | 1 | 4 | 3.6 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1 | 10.1016/s0960-894x(00)00232-8 | ||
| 10146377 | 67188 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 662 | 11 | 2 | 14 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL175058 | 67188 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 662 | 11 | 2 | 14 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| 71449713 | 88443 | 27 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 585 | 11 | 1 | 8 | 4.5 | CCCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2163694 | 88443 | 27 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 585 | 11 | 1 | 8 | 4.5 | CCCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| 10575061 | 213672 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 439 | 9 | 1 | 6 | 4.0 | CCCCC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9082 | 213672 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 439 | 9 | 1 | 6 | 4.0 | CCCCC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 22467266 | 92121 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 522 | 7 | 2 | 8 | 3.4 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261360 | 92121 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 522 | 7 | 2 | 8 | 3.4 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 | 10.1007/s00044-004-0021-y | ||
| 23445366 | 112960 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 482 | 7 | 1 | 5 | 6.2 | Cc1cc(CCC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL313801 | 112960 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 482 | 7 | 1 | 5 | 6.2 | Cc1cc(CCC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL2370070 | 216558 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| 71455140 | 88783 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 598 | 12 | 2 | 8 | 4.7 | CC(C)c1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2165336 | 88783 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 598 | 12 | 2 | 8 | 4.7 | CC(C)c1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | ||
| 71456865 | 88477 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 632 | 14 | 2 | 11 | 3.7 | COc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 | 10.1021/jm3009103 | ||
| CHEMBL2163727 | 88477 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 632 | 14 | 2 | 11 | 3.7 | COc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 | 10.1021/jm3009103 | ||
| 44284405 | 107132 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 532 | 10 | 2 | 7 | 5.4 | COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL289634 | 107132 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 532 | 10 | 2 | 7 | 5.4 | COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| 44284328 | 134319 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 476 | 7 | 2 | 7 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL36627 | 134319 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 476 | 7 | 2 | 7 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 9939238 | 210907 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 637 | 12 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70385 | 210907 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 637 | 12 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 44311345 | 210996 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 663 | 13 | 3 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70895 | 210996 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 663 | 13 | 3 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL85341 | 222667 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| 15411009 | 113967 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 691 | 14 | 1 | 12 | 5.6 | CCOC(=O)C(CC(C)C)NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | ||
| CHEMBL316523 | 113967 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 691 | 14 | 1 | 12 | 5.6 | CCOC(=O)C(CC(C)C)NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 | 10.1016/S0960-894X(97)00002-4 | ||
| 10938122 | 169785 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 4.8 | CC(C)Oc1ccc2c(c1)C(C(C)C)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL417555 | 169785 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 4.8 | CC(C)Oc1ccc2c(c1)C(C(C)C)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 135415889 | 66043 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 587 | 10 | 2 | 13 | 3.6 | C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL170401 | 66043 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 587 | 10 | 2 | 13 | 3.6 | C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 44266542 | 169589 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 521 | 7 | 1 | 7 | 6.1 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL417246 | 169589 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 521 | 7 | 1 | 7 | 6.1 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| 18617351 | 110886 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 384 | 3 | 1 | 4 | 3.9 | Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL309397 | 110886 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 384 | 3 | 1 | 4 | 3.9 | Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 18617407 | 211759 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 320 | 3 | 1 | 4 | 3.4 | Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL76576 | 211759 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 320 | 3 | 1 | 4 | 3.4 | Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 10788853 | 12882 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc(OC)cc3OC)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10808 | 12882 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc(OC)cc3OC)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| 10766396 | 117356 | 0 | None | - | 0 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 460 | 8 | 1 | 4 | 4.6 | CCCN(C)C(=O)CN1C[C@H](c2ccc3ccccc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL325418 | 117356 | 0 | None | - | 0 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 460 | 8 | 1 | 4 | 4.6 | CCCN(C)C(=O)CN1C[C@H](c2ccc3ccccc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 44276886 | 113610 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 410 | 4 | 1 | 4 | 4.2 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1Cl | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144600 | 113610 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 410 | 4 | 1 | 4 | 4.2 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1Cl | 10.1016/s0960-894x(00)00232-8 | ||
| 44459272 | 98015 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 491 | 6 | 2 | 7 | 2.6 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL24015 | 98015 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 491 | 6 | 2 | 7 | 2.6 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| 10279940 | 108128 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 527 | 8 | 2 | 10 | 3.6 | CC(=O)OCCc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm9608366 | ||
| CHEMBL296927 | 108128 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 527 | 8 | 2 | 10 | 3.6 | CC(=O)OCCc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm9608366 | ||
| 10504920 | 169889 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 480 | 6 | 2 | 9 | 3.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC#N)OCO3)c1Cl | 10.1021/jm9608366 | ||
| CHEMBL417719 | 169889 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 480 | 6 | 2 | 9 | 3.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC#N)OCO3)c1Cl | 10.1021/jm9608366 | ||
| 44384611 | 135432 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 644 | 10 | 2 | 12 | 5.8 | C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL366797 | 135432 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 644 | 10 | 2 | 12 | 5.8 | C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 44314647 | 211864 | 0 | None | - | 0 | Pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 647 | 13 | 5 | 4 | 5.1 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCCC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL77468 | 211864 | 0 | None | - | 0 | Pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 647 | 13 | 5 | 4 | 5.1 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCCC1)C(=O)O | 10.1021/jm9600914 | ||
| 10745418 | 120769 | 1 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 558 | 9 | 2 | 6 | 6.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C(C)C)cccc2C(C)C)cc1 | 10.1021/jm990170q | ||
| CHEMBL332627 | 120769 | 1 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 558 | 9 | 2 | 6 | 6.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C(C)C)cccc2C(C)C)cc1 | 10.1021/jm990170q | ||
| 44320461 | 113126 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 514 | 6 | 1 | 5 | 6.6 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL313920 | 113126 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 514 | 6 | 1 | 5 | 6.6 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| 10118046 | 16208 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 504 | 10 | 1 | 7 | 2.9 | CCCS(=O)(=O)N(C)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| CHEMBL111728 | 16208 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 504 | 10 | 1 | 7 | 2.9 | CCCS(=O)(=O)N(C)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| 44327659 | 116599 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 937 | 26 | 9 | 8 | 4.6 | CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 | 10.1021/jm00015a003 | ||
| CHEMBL323331 | 116599 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 937 | 26 | 9 | 8 | 4.6 | CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 | 10.1021/jm00015a003 | ||
| CHEMBL96822 | 222699 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NS(C)(=O)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 10789524 | 11964 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10607 | 11964 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2)cc1 | 10.1021/jm9606507 | ||
| 10530409 | 12478 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 536 | 9 | 1 | 10 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10781 | 12478 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 536 | 9 | 1 | 10 | 3.9 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | ||
| 73669821 | 124405 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 448 | 10 | 1 | 6 | 5.2 | CC(=O)c1ccc(OCc2ccc3c(c2)OCO3)cc1OC(CCC(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | ||
| CHEMBL3400988 | 124405 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 448 | 10 | 1 | 6 | 5.2 | CC(=O)c1ccc(OCc2ccc3c(c2)OCO3)cc1OC(CCC(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | ||
| 44295177 | 21553 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 534 | 10 | 1 | 9 | 5.0 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1C | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1206680 | 21553 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 534 | 10 | 1 | 9 | 5.0 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1C | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL295483 | 21553 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 534 | 10 | 1 | 9 | 5.0 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1C | 10.1016/s0960-894x(98)00301-1 | ||
| 10789525 | 68544 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm031041j | ||
| CHEMBL177221 | 68544 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 446 | 8 | 1 | 6 | 4.4 | COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm031041j | ||
| 10346184 | 15968 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL110366 | 15968 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL315328 | 217968 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| CHEMBL87252 | 222673 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00070a001 | ||||
| 18936171 | 203285 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 489 | 7 | 1 | 8 | 4.2 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2c(OC)c(OC)ccc21 | 10.1016/S0960-894X(97)00319-3 | ||
| CHEMBL56348 | 203285 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 489 | 7 | 1 | 8 | 4.2 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2c(OC)c(OC)ccc21 | 10.1016/S0960-894X(97)00319-3 | ||
| 44327252 | 214312 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 495 | 7 | 1 | 8 | 3.1 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C3CC3)ccc2=O)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL94654 | 214312 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 495 | 7 | 1 | 8 | 3.1 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C3CC3)ccc2=O)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| 44327226 | 214694 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 3.1 | CCc1cc(C)nn(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c1=O | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL96762 | 214694 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 3.1 | CCc1cc(C)nn(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c1=O | 10.1016/S0960-894X(96)00617-8 | ||
| 22616258 | 112183 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 372 | 5 | 1 | 4 | 3.8 | CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL311781 | 112183 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 372 | 5 | 1 | 4 | 3.8 | CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 9870959 | 15689 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | ||
| CHEMBL109778 | 15689 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | ||
| 10625152 | 117236 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 498 | 13 | 1 | 6 | 4.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccoc1 | 10.1021/jm980217s | ||
| CHEMBL324685 | 117236 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 498 | 13 | 1 | 6 | 4.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccoc1 | 10.1021/jm980217s | ||
| 44386621 | 68051 | 0 | None | - | 0 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 549 | 10 | 4 | 6 | 4.5 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL176653 | 68051 | 0 | None | - | 0 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 549 | 10 | 4 | 6 | 4.5 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O | 10.1021/jm950592+ | ||
| 11801544 | 68551 | 0 | None | - | 0 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 589 | 10 | 4 | 6 | 5.1 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2C3CC4CC(C3)CC2C4)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL177261 | 68551 | 0 | None | - | 0 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 589 | 10 | 4 | 6 | 5.1 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2C3CC4CC(C3)CC2C4)nc1C(=O)O | 10.1021/jm950592+ | ||
| 44385805 | 68070 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 532 | 10 | 1 | 10 | 4.1 | C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL176698 | 68070 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 532 | 10 | 1 | 10 | 4.1 | C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 10552413 | 117445 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 472 | 13 | 1 | 5 | 4.7 | C/C=C\CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| CHEMBL325935 | 117445 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 472 | 13 | 1 | 5 | 4.7 | C/C=C\CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| 10346184 | 15968 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | ||
| CHEMBL110366 | 15968 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | ||
| 21462925 | 126717 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 470 | 6 | 2 | 7 | 4.8 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc(N)ccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL349556 | 126717 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 470 | 6 | 2 | 7 | 4.8 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc(N)ccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL2304011 | 216246 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O | 10.1021/jm9600914 | ||||
| CHEMBL2369709 | 216431 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00152-J | ||||
| 44371421 | 58209 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 459 | 5 | 1 | 5 | 5.8 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3Cl)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL158204 | 58209 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 459 | 5 | 1 | 5 | 5.8 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3Cl)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| 10412464 | 15909 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 470 | 6 | 1 | 5 | 5.4 | COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10996 | 15909 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 470 | 6 | 1 | 5 | 5.4 | COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | ||
| 10961720 | 210263 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 472 | 6 | 1 | 5 | 6.3 | CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(C(C)C)cc1)O2 | 10.1021/jm010382z | ||
| CHEMBL66094 | 210263 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 472 | 6 | 1 | 5 | 6.3 | CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(C(C)C)cc1)O2 | 10.1021/jm010382z | ||
| 44314461 | 211558 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 605 | 13 | 5 | 4 | 3.9 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL74837 | 211558 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 605 | 13 | 5 | 4 | 3.9 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCC1)C(=O)O | 10.1021/jm9600914 | ||
| 10767778 | 23174 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)cc(C)c2)cc1 | 10.1021/jm990170q | ||
| CHEMBL123077 | 23174 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)cc(C)c2)cc1 | 10.1021/jm990170q | ||
| 10216862 | 203191 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 443 | 4 | 1 | 7 | 3.9 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n(Cc2ccc3c(c2)OCO3)c1=O | 10.1016/S0960-894X(97)00319-3 | ||
| CHEMBL56286 | 203191 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 443 | 4 | 1 | 7 | 3.9 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n(Cc2ccc3c(c2)OCO3)c1=O | 10.1016/S0960-894X(97)00319-3 | ||
| CHEMBL265066 | 103590 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 646 | 8 | 2 | 13 | 5.8 | COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC(=O)C2=C(C)N=C(C)/C(=C(/O)OC)[C@@H]2c2cccc([N+](=O)[O-])c2)[C@H]1c1cccc([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81025-8 | ||
| 22616257 | 211793 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 272 | 3 | 1 | 4 | 2.4 | Cc1noc(NS(=O)(=O)c2ccccc2)c1Cl | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL76860 | 211793 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 272 | 3 | 1 | 4 | 2.4 | Cc1noc(NS(=O)(=O)c2ccccc2)c1Cl | 10.1016/0960-894X(96)00441-6 | ||
| 44316831 | 212294 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 358 | 4 | 1 | 4 | 3.4 | CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2C)c1 | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80807 | 212294 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 358 | 4 | 1 | 4 | 3.4 | CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2C)c1 | 10.1016/0960-894X(96)00441-6 | ||
| 10070783 | 103831 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 4.5 | O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm9606507 | ||
| CHEMBL267094 | 103831 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 4.5 | O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm9606507 | ||
| 10502226 | 108305 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 420 | 6 | 1 | 8 | 3.3 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1C | 10.1021/jm9700068 | ||
| CHEMBL298203 | 108305 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 420 | 6 | 1 | 8 | 3.3 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1C | 10.1021/jm9700068 | ||
| 10719007 | 18013 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 465 | 6 | 1 | 9 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)C(C#N)c2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | ||
| CHEMBL1178895 | 18013 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 465 | 6 | 1 | 9 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)C(C#N)c2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | ||
| CHEMBL48448 | 18013 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 465 | 6 | 1 | 9 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)C(C#N)c2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | ||
| 10646637 | 213827 | 0 | None | - | 0 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 437 | 8 | 1 | 5 | 4.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C/C=C/CC(C)C)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9168 | 213827 | 0 | None | - | 0 | Pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 437 | 8 | 1 | 5 | 4.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C/C=C/CC(C)C)cc1 | 10.1021/jm9505369 | ||
| 10347080 | 92002 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 535 | 7 | 2 | 8 | 3.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL22562 | 92002 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 535 | 7 | 2 | 8 | 3.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1007/s00044-004-0021-y | ||
| 44314646 | 211818 | 0 | None | - | 0 | Pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 633 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL77033 | 211818 | 0 | None | - | 0 | Pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 633 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCC1)C(=O)O | 10.1021/jm9600914 | ||
| 11766844 | 116558 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 553 | 9 | 1 | 8 | 5.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)cc1 | 10.1021/jm0102304 | ||
| CHEMBL176272 | 116558 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 553 | 9 | 1 | 8 | 5.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)cc1 | 10.1021/jm0102304 | ||
| CHEMBL323243 | 116558 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 553 | 9 | 1 | 8 | 5.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)cc1 | 10.1021/jm0102304 | ||
| 10212088 | 103471 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 688 | 12 | 2 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL264035 | 103471 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 688 | 12 | 2 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | ||
| 9957883 | 105433 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL27732 | 105433 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| 44279370 | 113983 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 426 | 4 | 2 | 3 | 4.7 | CCc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL31662 | 113983 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 426 | 4 | 2 | 3 | 4.7 | CCc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 | 10.1016/0960-894X(95)00230-Q | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| 11091217 | 107844 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 426 | 9 | 1 | 6 | 5.0 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cc(OCCC)ccc21 | 10.1021/jm010382z | ||
| CHEMBL294787 | 107844 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 426 | 9 | 1 | 6 | 5.0 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cc(OCCC)ccc21 | 10.1021/jm010382z | ||
| 11014820 | 209691 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 398 | 6 | 1 | 6 | 4.2 | CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL62780 | 209691 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 398 | 6 | 1 | 6 | 4.2 | CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 10894688 | 210285 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 4.4 | COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)c1 | 10.1021/jm010382z | ||
| CHEMBL66246 | 210285 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 4.4 | COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)c1 | 10.1021/jm010382z | ||
| 44298325 | 202456 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 446 | 7 | 1 | 6 | 5.5 | CCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL55664 | 202456 | 0 | None | - | 0 | Pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 446 | 7 | 1 | 6 | 5.5 | CCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 44311218 | 109904 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 607 | 11 | 2 | 10 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccncc1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL307803 | 109904 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 607 | 11 | 2 | 10 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccncc1 | 10.1016/S0960-894X(97)00400-9 | ||
| 10278777 | 174911 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| CHEMBL432974 | 174911 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| 23445284 | 119579 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 5.4 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(C(C)C)cc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL330674 | 119579 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 5.4 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(C(C)C)cc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| 71455060 | 88438 | 1 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 614 | 9 | 1 | 9 | 2.9 | O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)N1CCOCC1 | 10.1021/jm3009103 | ||
| CHEMBL2163689 | 88438 | 1 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 614 | 9 | 1 | 9 | 2.9 | O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)N1CCOCC1 | 10.1021/jm3009103 | ||
| 44265861 | 103983 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 481 | 11 | 1 | 6 | 5.1 | CCCC(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL268433 | 103983 | 0 | None | - | 0 | Pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 481 | 11 | 1 | 6 | 5.1 | CCCC(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 10553384 | 116445 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 498 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 | 10.1021/jm980217s | ||
| CHEMBL322537 | 116445 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 498 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 | 10.1021/jm980217s | ||
| 25211074 | 25257 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 543 | 10 | 2 | 7 | 5.1 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL1272244 | 25257 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 543 | 10 | 2 | 7 | 5.1 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 25211074 | 25257 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 543 | 10 | 2 | 7 | 5.1 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL1272244 | 25257 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 543 | 10 | 2 | 7 | 5.1 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 44215416 | 181859 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 649 | 11 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccnc(-c3noc(=S)[nH]3)c2)nc1OCC1CCCO1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4568468 | 181859 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 649 | 11 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccnc(-c3noc(=S)[nH]3)c2)nc1OCC1CCCO1 | 10.1016/j.bmcl.2016.06.014 | ||
| 10205429 | 68380 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 470 | 8 | 2 | 9 | 2.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL177111 | 68380 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 470 | 8 | 2 | 9 | 2.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| 23445408 | 118412 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 5.5 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CC(C)C)cc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL328517 | 118412 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 5.5 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CC(C)C)cc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL2304006 | 216241 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | O=C(O)C[C@H]1NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm9600914 | ||||
| CHEMBL2304017 | 216252 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(C#N)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O | 10.1021/jm9600914 | ||||
| 70240112 | 178382 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 626 | 10 | 2 | 11 | 5.0 | CC#CCOc1nc(-c2ccnc(-c3nnn[nH]3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4465332 | 178382 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 626 | 10 | 2 | 11 | 5.0 | CC#CCOc1nc(-c2ccnc(-c3nnn[nH]3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| 21041288 | 180705 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 526 | 10 | 2 | 9 | 2.8 | CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4540866 | 180705 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 526 | 10 | 2 | 9 | 2.8 | CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL406279 | 219381 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| 44294712 | 21564 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 566 | 11 | 1 | 9 | 5.6 | COc1cc(C/C(C(=O)c2ccc(OC(C)C)c(F)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1206722 | 21564 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 566 | 11 | 1 | 9 | 5.6 | COc1cc(C/C(C(=O)c2ccc(OC(C)C)c(F)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL300201 | 21564 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 566 | 11 | 1 | 9 | 5.6 | COc1cc(C/C(C(=O)c2ccc(OC(C)C)c(F)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| 44284381 | 135287 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 462 | 6 | 3 | 7 | 4.3 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(O)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL36671 | 135287 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 462 | 6 | 3 | 7 | 4.3 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(O)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 17869371 | 21561 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 478 | 8 | 1 | 7 | 4.8 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(F)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1206716 | 21561 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 478 | 8 | 1 | 7 | 4.8 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(F)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL299521 | 21561 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 478 | 8 | 1 | 7 | 4.8 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(F)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| 10457385 | 119465 | 0 | None | - | 1 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 469 | 6 | 1 | 8 | 2.5 | Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL330424 | 119465 | 0 | None | - | 1 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 469 | 6 | 1 | 8 | 2.5 | Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| 10527706 | 103776 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 454 | 8 | 1 | 6 | 3.1 | CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL266594 | 103776 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 454 | 8 | 1 | 6 | 3.1 | CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 18995990 | 106132 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL282426 | 106132 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 507 | 7 | 1 | 9 | 5.0 | COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 | 10.1016/0960-894X(96)00232-6 | ||
| 18617385 | 211991 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 286 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL78601 | 211991 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 286 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 44277387 | 113627 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 3.0 | O=C(O)COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144800 | 113627 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 3.0 | O=C(O)COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 10366742 | 113885 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 5.5 | CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL316012 | 113885 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 5.5 | CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(96)00496-9 | ||
| 10715441 | 182705 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 390 | 6 | 1 | 6 | 3.9 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm9700068 | ||
| CHEMBL45875 | 182705 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 390 | 6 | 1 | 6 | 3.9 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm9700068 | ||
| 10697636 | 174599 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 536 | 13 | 1 | 7 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1SCCS1 | 10.1021/jm980217s | ||
| CHEMBL430683 | 174599 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 536 | 13 | 1 | 7 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1SCCS1 | 10.1021/jm980217s | ||
| 135512539 | 135252 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 615 | 11 | 2 | 13 | 4.4 | C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL366652 | 135252 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 615 | 11 | 2 | 13 | 4.4 | C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 10529715 | 213929 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)CC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9228 | 213929 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)CC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44384852 | 67014 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 544 | 9 | 1 | 8 | 5.5 | C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL174094 | 67014 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 544 | 9 | 1 | 8 | 5.5 | C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL67074 | 210393 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 646 | 8 | 2 | 13 | 5.8 | COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC(=O)C2=C(C)N=C(C)/C(=C(/O)OC)[C@@H]2c2cccc([N+](=O)[O-])c2)[C@@H]1c1cccc([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81025-8 | ||
| 44386162 | 67183 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 575 | 11 | 1 | 9 | 6.2 | CC/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL175005 | 67183 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 575 | 11 | 1 | 9 | 6.2 | CC/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 44383754 | 66657 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 452 | 5 | 1 | 5 | 5.4 | Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL172987 | 66657 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 452 | 5 | 1 | 5 | 5.4 | Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| 44383742 | 175284 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 452 | 5 | 1 | 5 | 5.4 | Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL435346 | 175284 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 452 | 5 | 1 | 5 | 5.4 | Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| 44339662 | 16624 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 527 | 13 | 1 | 7 | 4.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1nc(C)c(C)o1 | 10.1021/jm980217s | ||
| CHEMBL114074 | 16624 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 527 | 13 | 1 | 7 | 4.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1nc(C)c(C)o1 | 10.1021/jm980217s | ||
| 44385523 | 67838 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 666 | 13 | 2 | 9 | 5.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL176418 | 67838 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 666 | 13 | 2 | 9 | 5.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 17885918 | 112750 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 458 | 6 | 1 | 6 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccsc2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL313044 | 112750 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 458 | 6 | 1 | 6 | 5.9 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccsc2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| 44320431 | 113733 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 526 | 9 | 2 | 7 | 4.9 | O=C(O)COC1CCCCC1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL314973 | 113733 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 526 | 9 | 2 | 7 | 4.9 | O=C(O)COC1CCCCC1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | ||
| 10723203 | 18222 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 678 | 14 | 2 | 7 | 6.8 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| CHEMBL1180350 | 18222 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 678 | 14 | 2 | 7 | 6.8 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| CHEMBL123206 | 18222 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 678 | 14 | 2 | 7 | 6.8 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| 9961347 | 18734 | 1 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 664 | 13 | 2 | 7 | 6.6 | Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| CHEMBL1182945 | 18734 | 1 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 664 | 13 | 2 | 7 | 6.6 | Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| CHEMBL273642 | 18734 | 1 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 664 | 13 | 2 | 7 | 6.6 | Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| 44320212 | 113777 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 520 | 9 | 2 | 7 | 4.7 | O=C(O)COc1ccccc1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL315280 | 113777 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 520 | 9 | 2 | 7 | 4.7 | O=C(O)COc1ccccc1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | ||
| 10768904 | 18902 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL1184117 | 18902 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL333034 | 18902 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 10 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| 10555208 | 19177 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 578 | 9 | 2 | 6 | 5.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| CHEMBL1185774 | 19177 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 578 | 9 | 2 | 6 | 5.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| CHEMBL432227 | 19177 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 578 | 9 | 2 | 6 | 5.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2C)cc1 | 10.1021/jm990171i | ||
| 17885921 | 113578 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 453 | 6 | 1 | 6 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccn2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL314454 | 113578 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 453 | 6 | 1 | 6 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccn2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| 155511294 | 176348 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 469 | 6 | 1 | 8 | 2.5 | Cc1ccc(=O)n([C@@H](C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4435789 | 176348 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 469 | 6 | 1 | 8 | 2.5 | Cc1ccc(=O)n([C@@H](C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/j.bmcl.2016.06.014 | ||
| 9985589 | 175022 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 576 | 9 | 1 | 8 | 5.0 | CCN(c1ccc2c(c1)oc1c(-c3ccc(OC)cc3)c(C(=O)O)c(=O)n(Cc3ccccc3OC)c12)S(C)(=O)=O | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL433700 | 175022 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 576 | 9 | 1 | 8 | 5.0 | CCN(c1ccc2c(c1)oc1c(-c3ccc(OC)cc3)c(C(=O)O)c(=O)n(Cc3ccccc3OC)c12)S(C)(=O)=O | 10.1016/s0960-894x(99)00040-2 | ||
| 44315008 | 109608 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 665 | 13 | 5 | 5 | 4.7 | CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL305524 | 109608 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 665 | 13 | 5 | 5 | 4.7 | CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 10792636 | 175294 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 544 | 10 | 2 | 6 | 5.4 | CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 | 10.1021/jm990170q | ||
| CHEMBL435385 | 175294 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 544 | 10 | 2 | 6 | 5.4 | CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 | 10.1021/jm990170q | ||
| CHEMBL408437 | 219492 | 0 | None | - | 0 | Bovine | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]cn2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/S0960-894X(97)00296-5 | ||||
| 10769177 | 119689 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.2 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCOC)cc1 | 10.1021/jm990170q | ||
| CHEMBL331066 | 119689 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.2 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCOC)cc1 | 10.1021/jm990170q | ||
| 11006532 | 19015 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 601 | 10 | 1 | 9 | 6.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3cccs3)cn2)cc1 | 10.1021/jm0102304 | ||
| CHEMBL1184515 | 19015 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 601 | 10 | 1 | 9 | 6.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3cccs3)cn2)cc1 | 10.1021/jm0102304 | ||
| CHEMBL367445 | 19015 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 601 | 10 | 1 | 9 | 6.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3cccs3)cn2)cc1 | 10.1021/jm0102304 | ||
| 10119177 | 124243 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 528 | 12 | 1 | 6 | 4.8 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm010237l | ||
| CHEMBL339904 | 124243 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 528 | 12 | 1 | 6 | 4.8 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | 10.1021/jm010237l | ||
| 44327890 | 148190 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 985 | 26 | 9 | 8 | 5.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL384052 | 148190 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 985 | 26 | 9 | 8 | 5.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL146155 | 215554 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | ||||
| 44333913 | 11873 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.8 | CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL105591 | 11873 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.8 | CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| 44371410 | 56195 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 5.5 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL156453 | 56195 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 5.5 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| 11827657 | 26153 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 540 | 13 | 1 | 7 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 | 10.1021/jm010237l | ||
| CHEMBL129220 | 26153 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 540 | 13 | 1 | 7 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 | 10.1021/jm010237l | ||
| 44279126 | 107503 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 3 | 2 | 3 | 5.5 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3Cl)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL29265 | 107503 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 3 | 2 | 3 | 5.5 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3Cl)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| 44279128 | 113689 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 428 | 4 | 2 | 4 | 4.2 | COc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL31469 | 113689 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 428 | 4 | 2 | 4 | 4.2 | COc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 | 10.1016/0960-894X(95)00230-Q | ||
| 44279349 | 174926 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 3 | 2 | 3 | 5.3 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cccc4ccccc34)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL433039 | 174926 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 3 | 2 | 3 | 5.3 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cccc4ccccc34)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| 44298393 | 206610 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.2 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2C)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL59425 | 206610 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.2 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2C)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 44309996 | 210538 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 483 | 5 | 1 | 8 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4nsnc4c3)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(97)10151-2 | ||
| CHEMBL67971 | 210538 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 483 | 5 | 1 | 8 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4nsnc4c3)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(97)10151-2 | ||
| 9870830 | 213493 | 38 | None | -66 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/s0960-894x(97)10151-2 | ||
| CHEMBL8981 | 213493 | 38 | None | -66 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/s0960-894x(97)10151-2 | ||
| 44387128 | 175368 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 558 | 12 | 2 | 10 | 3.8 | CNCC(=O)OCCOc1nc(C)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL435895 | 175368 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 558 | 12 | 2 | 10 | 3.8 | CNCC(=O)OCCOc1nc(C)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/S0960-894X(97)00400-9 | ||
| 44371571 | 126267 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 425 | 5 | 1 | 5 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL345380 | 126267 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 425 | 5 | 1 | 5 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL414168 | 219895 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00296-5 | ||||
| CHEMBL436894 | 220472 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00296-5 | ||||
| CHEMBL437610 | 220506 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00296-5 | ||||
| 10767505 | 12072 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 494 | 6 | 1 | 8 | 3.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10661 | 12072 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 494 | 6 | 1 | 8 | 3.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(S(C)(=O)=O)cc2)cc1 | 10.1021/jm9606507 | ||
| 10601191 | 119581 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 492 | 11 | 3 | 6 | 5.7 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc(C(=O)O)[nH]n1 | 10.1021/jm9707131 | ||
| CHEMBL330679 | 119581 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 492 | 11 | 3 | 6 | 5.7 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc(C(=O)O)[nH]n1 | 10.1021/jm9707131 | ||
| CHEMBL293874 | 217671 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | None | None | None | CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)CN(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00089a028 | ||||
| 22616255 | 212312 | 11 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 297 | 4 | 1 | 6 | 2.0 | Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80945 | 212312 | 11 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 297 | 4 | 1 | 6 | 2.0 | Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 345351 | 16131 | 4 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 386 | 4 | 1 | 5 | 3.8 | O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm9606507 | ||
| CHEMBL11131 | 16131 | 4 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 386 | 4 | 1 | 5 | 3.8 | O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm9606507 | ||
| 44298419 | 168778 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 420 | 3 | 1 | 4 | 3.7 | Cc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1I | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL415942 | 168778 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 420 | 3 | 1 | 4 | 3.7 | Cc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1I | 10.1016/s0960-894x(00)00366-8 | ||
| 44386370 | 67189 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 531 | 10 | 4 | 6 | 4.8 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL175066 | 67189 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 531 | 10 | 4 | 6 | 4.8 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL342615 | 218454 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | ||||
| 10347080 | 92002 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 7 | 2 | 8 | 3.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL22562 | 92002 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 7 | 2 | 8 | 3.0 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | ||
| 10576379 | 108048 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 471 | 6 | 2 | 7 | 3.9 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | ||
| CHEMBL296291 | 108048 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 471 | 6 | 2 | 7 | 3.9 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | ||
| 10790376 | 173688 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 3.3 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N2CCCCC2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL428644 | 173688 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 3.3 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N2CCCCC2)cc1 | 10.1021/jm9505369 | ||
| 11827489 | 123764 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 5.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 | 10.1021/jm010237l | ||
| CHEMBL338754 | 123764 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 5.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 | 10.1021/jm010237l | ||
| 9916121 | 88442 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 571 | 10 | 1 | 8 | 4.1 | CCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2163693 | 88442 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 571 | 10 | 1 | 8 | 4.1 | CCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| 10792319 | 214013 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 530 | 10 | 1 | 6 | 5.1 | CCCCN(C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm9505369 | ||
| CHEMBL9283 | 214013 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 530 | 10 | 1 | 6 | 5.1 | CCCCN(C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm9505369 | ||
| 44265869 | 104037 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 3.3 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2CCCC2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL268864 | 104037 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 3.3 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2CCCC2)cc1 | 10.1021/jm9505369 | ||
| 23445457 | 135802 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 470 | 6 | 1 | 6 | 5.1 | Cc1cc(C)c(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL367024 | 135802 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 470 | 6 | 1 | 6 | 5.1 | Cc1cc(C)c(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00132-7 | ||
| 10962637 | 16851 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 549 | 10 | 2 | 9 | 4.3 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(CO)cn2)cc1 | 10.1021/jm000538f | ||
| CHEMBL115372 | 16851 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 549 | 10 | 2 | 9 | 4.3 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(CO)cn2)cc1 | 10.1021/jm000538f | ||
| CHEMBL1627023 | 16851 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 549 | 10 | 2 | 9 | 4.3 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(CO)cn2)cc1 | 10.1021/jm000538f | ||
| 10531506 | 18888 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2cc(C)ccc2C)cc1 | 10.1021/jm990171i | ||
| CHEMBL1184076 | 18888 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2cc(C)ccc2C)cc1 | 10.1021/jm990171i | ||
| CHEMBL331548 | 18888 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 592 | 9 | 2 | 6 | 5.8 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2cc(C)ccc2C)cc1 | 10.1021/jm990171i | ||
| CHEMBL2304013 | 216248 | 0 | None | - | 0 | Pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CC(C)[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC1=O | 10.1021/jm9600914 | ||||
| 44320474 | 113845 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 440 | 8 | 1 | 5 | 5.7 | CCC(CC)Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL315752 | 113845 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 440 | 8 | 1 | 5 | 5.7 | CCC(CC)Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm0102304 | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm0102304 | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm0102304 | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm0102304 | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm0102304 | ||
| 44298330 | 108325 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 518 | 10 | 1 | 8 | 5.4 | COC(=O)CCCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL298340 | 108325 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 518 | 10 | 1 | 8 | 5.4 | COC(=O)CCCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 44458650 | 91678 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 521 | 7 | 2 | 8 | 2.7 | COc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL22367 | 91678 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 521 | 7 | 2 | 8 | 2.7 | COc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | ||
| 155544917 | 180193 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 540 | 13 | 2 | 10 | 3.4 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4528516 | 180193 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 540 | 13 | 2 | 10 | 3.4 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 11732155 | 209445 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 4.4 | COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | ||
| CHEMBL61460 | 209445 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 4.4 | COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | ||
| 10672060 | 16032 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 470 | 10 | 1 | 6 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)c(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL110794 | 16032 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 470 | 10 | 1 | 6 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)c(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 19385674 | 105365 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 715 | 13 | 1 | 7 | 8.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL276819 | 105365 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 715 | 13 | 1 | 7 | 8.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br | 10.1016/0960-894X(95)00186-W | ||
| 19385674 | 105365 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 715 | 13 | 1 | 7 | 8.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br | 10.1021/jm058225d | ||
| CHEMBL276819 | 105365 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 715 | 13 | 1 | 7 | 8.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br | 10.1021/jm058225d | ||
| 52943105 | 25251 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 529 | 9 | 2 | 7 | 4.7 | CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL1272190 | 25251 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 529 | 9 | 2 | 7 | 4.7 | CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 52943105 | 25251 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 529 | 9 | 2 | 7 | 4.7 | CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| CHEMBL1272190 | 25251 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 529 | 9 | 2 | 7 | 4.7 | CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| 10744973 | 214055 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 538 | 14 | 1 | 6 | 5.5 | CCCCCN(CCCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9313 | 214055 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 538 | 14 | 1 | 6 | 5.5 | CCCCCN(CCCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 155517241 | 176937 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 522 | 14 | 2 | 11 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4444355 | 176937 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 522 | 14 | 2 | 11 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| 44265870 | 214350 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 524 | 12 | 1 | 6 | 5.1 | CCCCN(CCCC)C(=O)C(C)N1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9488 | 214350 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 524 | 12 | 1 | 6 | 5.1 | CCCCN(CCCC)C(=O)C(C)N1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44384715 | 67136 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 559 | 9 | 1 | 9 | 5.2 | CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL174607 | 67136 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 559 | 9 | 1 | 9 | 5.2 | CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 10305334 | 135825 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 680 | 12 | 2 | 11 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL367036 | 135825 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 680 | 12 | 2 | 11 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | ||
| 10671928 | 14048 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 467 | 5 | 1 | 7 | 4.4 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2nccc3ccccc23)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10860 | 14048 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 467 | 5 | 1 | 7 | 4.4 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2nccc3ccccc23)cc1 | 10.1021/jm9606507 | ||
| 44295089 | 21404 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 476 | 8 | 1 | 7 | 5.4 | COc1ccc(C(=O)/C(Cc2ccc(SC)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1205088 | 21404 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 476 | 8 | 1 | 7 | 5.4 | COc1ccc(C(=O)/C(Cc2ccc(SC)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL51030 | 21404 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 476 | 8 | 1 | 7 | 5.4 | COc1ccc(C(=O)/C(Cc2ccc(SC)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| 15340613 | 113621 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144732 | 113621 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 10837666 | 176667 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 460 | 8 | 1 | 4 | 4.6 | CCCN(C)C(=O)CN1C[C@H](c2cccc3ccccc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL444061 | 176667 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 460 | 8 | 1 | 4 | 4.6 | CCCN(C)C(=O)CN1C[C@H](c2cccc3ccccc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 9870959 | 15689 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | ||
| CHEMBL109778 | 15689 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 509 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 | 10.1021/jm980217s | ||
| 71451529 | 88468 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 632 | 14 | 2 | 12 | 3.4 | CCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| CHEMBL2163719 | 88468 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 632 | 14 | 2 | 12 | 3.4 | CCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| 18184228 | 68127 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 604 | 13 | 2 | 9 | 4.6 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL176749 | 68127 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 604 | 13 | 2 | 9 | 4.6 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 44384651 | 135277 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 498 | 6 | 2 | 8 | 4.0 | Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2CO)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL366680 | 135277 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 498 | 6 | 2 | 8 | 4.0 | Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2CO)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| 10696210 | 106324 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 483 | 6 | 2 | 9 | 3.7 | CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm9608366 | ||
| CHEMBL283535 | 106324 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 483 | 6 | 2 | 9 | 3.7 | CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm9608366 | ||
| 44291884 | 179677 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 483 | 6 | 2 | 9 | 3.7 | CC(=O)c1c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)ccc2c1OCO2 | 10.1021/jm9700068 | ||
| CHEMBL45160 | 179677 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 483 | 6 | 2 | 9 | 3.7 | CC(=O)c1c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)ccc2c1OCO2 | 10.1021/jm9700068 | ||
| 11795139 | 173316 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 398 | 6 | 2 | 6 | 1.8 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 | 10.1021/jm9505369 | ||
| CHEMBL427935 | 173316 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 398 | 6 | 2 | 6 | 1.8 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 | 10.1021/jm9505369 | ||
| 23445516 | 113405 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 5.9 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CCC(C)C)cc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL314307 | 113405 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 5.9 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CCC(C)C)cc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| 44384757 | 172927 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 482 | 5 | 1 | 7 | 4.8 | Cc1cc2c(cc1/C=C/c1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL426218 | 172927 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 482 | 5 | 1 | 7 | 4.8 | Cc1cc2c(cc1/C=C/c1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL216082 | 216096 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| CHEMBL2370255 | 216598 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 9830495 | 137927 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 618 | 14 | 2 | 9 | 5.0 | CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL368617 | 137927 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 618 | 14 | 2 | 9 | 5.0 | CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL94907 | 222693 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | ||||
| 11505449 | 178263 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 616 | 12 | 3 | 9 | 2.6 | O=C(O)CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4463633 | 178263 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 616 | 12 | 3 | 9 | 2.6 | O=C(O)CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 44309814 | 109783 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 487 | 8 | 1 | 7 | 6.2 | CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1cc2nsnc2cc1C | 10.1016/s0960-894x(97)10151-2 | ||
| CHEMBL306863 | 109783 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 487 | 8 | 1 | 7 | 6.2 | CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1cc2nsnc2cc1C | 10.1016/s0960-894x(97)10151-2 | ||
| 9909467 | 212290 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 409 | 4 | 1 | 5 | 3.8 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80782 | 212290 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 409 | 4 | 1 | 5 | 3.8 | Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL86814 | 222671 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | ||||
| 44213279 | 113625 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 456 | 6 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144737 | 113625 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 456 | 6 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL86814 | 222671 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | ||||
| 44266549 | 169146 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 415 | 4 | 1 | 6 | 4.5 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL416518 | 169146 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 415 | 4 | 1 | 6 | 4.5 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| 44316458 | 212220 | 2 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 408 | 3 | 1 | 4 | 3.6 | Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80317 | 212220 | 2 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 408 | 3 | 1 | 4 | 3.6 | Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 44277034 | 113620 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1ccccc1Cn1[nH]c(C(F)(F)F)c(Cc2ccc3c(c2)OCO3)c1=O | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144729 | 113620 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1ccccc1Cn1[nH]c(C(F)(F)F)c(Cc2ccc3c(c2)OCO3)c1=O | 10.1016/s0960-894x(00)00232-8 | ||
| 10576910 | 115316 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 486 | 13 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C(C)C | 10.1021/jm980217s | ||
| CHEMBL320124 | 115316 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 486 | 13 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C(C)C | 10.1021/jm980217s | ||
| 44384826 | 66750 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 561 | 10 | 1 | 9 | 5.8 | C/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL173366 | 66750 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 561 | 10 | 1 | 9 | 5.8 | C/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 22998456 | 66568 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.9 | CCCc1cc2c(cc1OCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL172666 | 66568 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.9 | CCCc1cc2c(cc1OCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00132-7 | ||
| 10694547 | 213854 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 443 | 10 | 1 | 7 | 2.9 | COCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9183 | 213854 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 443 | 10 | 1 | 7 | 2.9 | COCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 10507467 | 15272 | 0 | None | - | 0 | Pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 580 | 12 | 1 | 7 | 4.5 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)Cc1ccccc1 | 10.1021/jm970101g | ||
| CHEMBL109408 | 15272 | 0 | None | - | 0 | Pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 580 | 12 | 1 | 7 | 4.5 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)Cc1ccccc1 | 10.1021/jm970101g | ||
| 44314660 | 111142 | 0 | None | - | 0 | Pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 633 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL310111 | 111142 | 0 | None | - | 0 | Pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 633 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1C)C(=O)O | 10.1021/jm9600914 | ||
| 22467235 | 103300 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 533 | 7 | 2 | 7 | 3.8 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL262784 | 103300 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 533 | 7 | 2 | 7 | 3.8 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| 10050696 | 103553 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 7 | 1 | 6 | 5.3 | COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL26474 | 103553 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 7 | 1 | 6 | 5.3 | COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| 10050696 | 103553 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 7 | 1 | 6 | 5.3 | COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL26474 | 103553 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 7 | 1 | 6 | 5.3 | COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 73669992 | 124409 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 387 | 9 | 1 | 4 | 5.4 | N#CCCC(Oc1cc(OCc2ccccc2)ccc1C(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | ||
| CHEMBL3400998 | 124409 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 387 | 9 | 1 | 4 | 5.4 | N#CCCC(Oc1cc(OCc2ccccc2)ccc1C(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | ||
| 23670447 | 9803 | 2 | None | - | 2 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(98)00301-1 | ||
| 999 | 9803 | 2 | None | - | 2 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1204799 | 9803 | 2 | None | - | 2 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL25438 | 9803 | 2 | None | - | 2 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1016/s0960-894x(98)00301-1 | ||
| 10311570 | 21402 | 0 | None | - | 1 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1205068 | 21402 | 0 | None | - | 1 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL48907 | 21402 | 0 | None | - | 1 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| 44295206 | 21565 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 580 | 12 | 1 | 11 | 4.7 | COc1cc(C/C(C(=O)c2cc(OC)c(OC)c(OC)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1206728 | 21565 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 580 | 12 | 1 | 11 | 4.7 | COc1cc(C/C(C(=O)c2cc(OC)c(OC)c(OC)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL301577 | 21565 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 580 | 12 | 1 | 11 | 4.7 | COc1cc(C/C(C(=O)c2cc(OC)c(OC)c(OC)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| 9871348 | 210806 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 520 | 8 | 1 | 10 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4nsnc4c3)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/s0960-894x(97)10151-2 | ||
| CHEMBL69741 | 210806 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 520 | 8 | 1 | 10 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc4nsnc4c3)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/s0960-894x(97)10151-2 | ||
| 18617366 | 174615 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 394 | 3 | 1 | 4 | 3.3 | Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL430822 | 174615 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 394 | 3 | 1 | 4 | 3.3 | Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 11102609 | 175349 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 462 | 6 | 1 | 6 | 5.2 | COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1021/jm010382z | ||
| CHEMBL435773 | 175349 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 462 | 6 | 1 | 6 | 5.2 | COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1021/jm010382z | ||
| 10790183 | 213024 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 461 | 8 | 1 | 6 | 4.3 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOc2ccccc2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL8677 | 213024 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 461 | 8 | 1 | 6 | 4.3 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOc2ccccc2)cc1 | 10.1021/jm9505369 | ||
| 10673715 | 16323 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 528 | 14 | 1 | 5 | 5.4 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(F)(F)F | 10.1021/jm980217s | ||
| CHEMBL112314 | 16323 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 528 | 14 | 1 | 5 | 5.4 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(F)(F)F | 10.1021/jm980217s | ||
| 10789715 | 119875 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 4.2 | CCCN(C)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL331375 | 119875 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 4.2 | CCCN(C)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL2369711 | 216433 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00152-J | ||||
| 10697633 | 67108 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 536 | 10 | 5 | 5 | 4.4 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL174448 | 67108 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 536 | 10 | 5 | 5 | 4.4 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| 10415348 | 67862 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 557 | 9 | 3 | 6 | 4.8 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCc3ccccc32)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL176514 | 67862 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 557 | 9 | 3 | 6 | 4.8 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCc3ccccc32)nc1C(=O)O | 10.1021/jm950592+ | ||
| 10697633 | 67108 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 536 | 10 | 5 | 5 | 4.4 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| CHEMBL174448 | 67108 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 536 | 10 | 5 | 5 | 4.4 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| 71456862 | 88458 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 651 | 12 | 1 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163709 | 88458 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 651 | 12 | 1 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 10274552 | 80288 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 434 | 6 | 1 | 8 | 3.6 | Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 | 10.1021/jm9700068 | ||
| CHEMBL20168 | 80288 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 434 | 6 | 1 | 8 | 3.6 | Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 | 10.1021/jm9700068 | ||
| 9807200 | 92120 | 0 | None | -346 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 3.6 | COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261359 | 92120 | 0 | None | -346 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 3.6 | COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 | 10.1007/s00044-004-0021-y | ||
| 71458720 | 88459 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 665 | 13 | 1 | 12 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163710 | 88459 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 665 | 13 | 1 | 12 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 23445533 | 67186 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 5.0 | Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL175045 | 67186 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 5.0 | Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| 10896412 | 209583 | 0 | None | - | 0 | Pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 504 | 9 | 1 | 7 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1OC)O2 | 10.1021/jm010382z | ||
| CHEMBL62277 | 209583 | 0 | None | - | 0 | Pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 504 | 9 | 1 | 7 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1OC)O2 | 10.1021/jm010382z | ||
| CHEMBL327350 | 218069 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | ||||
| 44327585 | 168562 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 992 | 26 | 9 | 8 | 5.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL414082 | 168562 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 992 | 26 | 9 | 8 | 5.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 44368824 | 103602 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 1595 | 31 | 19 | 20 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | ||
| 77282142 | 103602 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 1595 | 31 | 19 | 20 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | ||
| CHEMBL265164 | 103602 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 1595 | 31 | 19 | 20 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | ||
| 10982740 | 210162 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 5 | 1 | 5 | 5.4 | CC(C)Oc1ccc2c(c1)C(C1CCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL65353 | 210162 | 0 | None | - | 0 | Pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 5 | 1 | 5 | 5.4 | CC(C)Oc1ccc2c(c1)C(C1CCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 44371429 | 55674 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 5.2 | COc1cccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL155973 | 55674 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 5.2 | COc1cccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 | 10.1016/s0960-894x(99)00040-2 | ||
| 11762291 | 107412 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL292041 | 107412 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 9807178 | 209770 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 384 | 5 | 1 | 6 | 3.8 | COC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL63121 | 209770 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 384 | 5 | 1 | 6 | 3.8 | COC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 10648006 | 168445 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 468 | 6 | 1 | 6 | 4.7 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1021/jm9700068 | ||
| CHEMBL413093 | 168445 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 468 | 6 | 1 | 6 | 4.7 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1021/jm9700068 | ||
| CHEMBL438194 | 220532 | 14 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | ||||
| 9848132 | 214356 | 0 | None | - | 2 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 483 | 6 | 1 | 8 | 2.8 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL94918 | 214356 | 0 | None | - | 2 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 483 | 6 | 1 | 8 | 2.8 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| 44368417 | 51423 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 504 | 12 | 2 | 6 | 4.9 | COc1ccc(CN(Cc2cc(OC)c(OC)c(OC)c2)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL152065 | 51423 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 504 | 12 | 2 | 6 | 4.9 | COc1ccc(CN(Cc2cc(OC)c(OC)c(OC)c2)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| 18617302 | 111193 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 334 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccccc2F)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL310361 | 111193 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 334 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2ccccc2F)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 44298394 | 169814 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 3.8 | CSc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)noc1C | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL417595 | 169814 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 3.8 | CSc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)noc1C | 10.1016/s0960-894x(00)00366-8 | ||
| 10575356 | 16481 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 446 | 8 | 1 | 4 | 3.7 | CCCN(C)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL113184 | 16481 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 446 | 8 | 1 | 4 | 3.7 | CCCN(C)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 10298764 | 16626 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 468 | 8 | 1 | 6 | 3.2 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL114084 | 16626 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 468 | 8 | 1 | 6 | 3.2 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 10647182 | 116499 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 449 | 8 | 2 | 4 | 3.9 | CCCN(C)C(=O)CN1C[C@H](c2ccc3cc[nH]c3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL322935 | 116499 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 449 | 8 | 2 | 4 | 3.9 | CCCN(C)C(=O)CN1C[C@H](c2ccc3cc[nH]c3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 10765567 | 118131 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 440 | 9 | 1 | 5 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2cccc(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL326951 | 118131 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 440 | 9 | 1 | 5 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2cccc(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 10415822 | 136597 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 579 | 9 | 3 | 7 | 4.7 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCOC23CCCCC3)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL367551 | 136597 | 0 | None | - | 0 | Pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 579 | 9 | 3 | 7 | 4.7 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCOC23CCCCC3)nc1C(=O)O | 10.1021/jm950592+ | ||
| 44384610 | 135249 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 743 | 16 | 2 | 14 | 4.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL366627 | 135249 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 743 | 16 | 2 | 14 | 4.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 10813822 | 103745 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 460 | 5 | 2 | 5 | 4.5 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)Nc2ccccc2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL266336 | 103745 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 460 | 5 | 2 | 5 | 4.5 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)Nc2ccccc2)cc1 | 10.1021/jm9505369 | ||
| 22998447 | 213454 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 414 | 5 | 1 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2sccc2Oc2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL89457 | 213454 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 414 | 5 | 1 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2sccc2Oc2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| 10226215 | 108209 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 455 | 5 | 2 | 8 | 3.8 | Cc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm9608366 | ||
| CHEMBL297473 | 108209 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 455 | 5 | 2 | 8 | 3.8 | Cc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 | 10.1021/jm9608366 | ||
| 10648715 | 116446 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 488 | 14 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC(C)C | 10.1021/jm980217s | ||
| CHEMBL322547 | 116446 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 488 | 14 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC(C)C | 10.1021/jm980217s | ||
| 10598270 | 103719 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 4.1 | CCCC#CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL266144 | 103719 | 0 | None | - | 0 | Pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 4.1 | CCCC#CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 10302092 | 118114 | 0 | None | - | 0 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 532 | 12 | 1 | 7 | 3.7 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC | 10.1021/jm970101g | ||
| CHEMBL326861 | 118114 | 0 | None | - | 0 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 532 | 12 | 1 | 7 | 3.7 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC | 10.1021/jm970101g | ||
| CHEMBL267754 | 217509 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(96)00127-8 | ||||
| CHEMBL327350 | 218069 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| 10907399 | 209735 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 516 | 11 | 1 | 6 | 6.8 | CCCCOc1ccc(C2Oc3ccc(OCCCC)cc3C(c3ccc4c(c3)OCO4)=C2C(=O)O)cc1 | 10.1021/jm010382z | ||
| CHEMBL62976 | 209735 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 516 | 11 | 1 | 6 | 6.8 | CCCCOc1ccc(C2Oc3ccc(OCCCC)cc3C(c3ccc4c(c3)OCO4)=C2C(=O)O)cc1 | 10.1021/jm010382z | ||
| 10577405 | 16424 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1C(C)(C)CCCC | 10.1021/jm980217s | ||
| CHEMBL112777 | 16424 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1C(C)(C)CCCC | 10.1021/jm980217s | ||
| 10767280 | 115445 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 486 | 14 | 1 | 5 | 5.1 | C=C(C)CCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| CHEMBL320763 | 115445 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 486 | 14 | 1 | 5 | 5.1 | C=C(C)CCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| 44277367 | 113615 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 392 | 4 | 2 | 5 | 3.3 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144606 | 113615 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 392 | 4 | 2 | 5 | 3.3 | O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 10168195 | 68161 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 631 | 11 | 2 | 13 | 5.0 | C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL176999 | 68161 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 631 | 11 | 2 | 13 | 5.0 | C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 18184179 | 135800 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 654 | 13 | 2 | 12 | 4.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL367017 | 135800 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 654 | 13 | 2 | 12 | 4.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL421190 | 220048 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| CHEMBL94525 | 222690 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | ||||
| 18617322 | 212239 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 350 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2ccccc2Cl)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80438 | 212239 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 350 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2ccccc2Cl)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 44385593 | 136252 | 0 | None | - | 0 | Pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 530 | 10 | 5 | 5 | 4.5 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL367208 | 136252 | 0 | None | - | 0 | Pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 530 | 10 | 5 | 5 | 4.5 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O | 10.1021/jm950592+ | ||
| 10839533 | 108222 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 513 | 5 | 2 | 9 | 2.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NC(=O)c2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| CHEMBL297599 | 108222 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 513 | 5 | 2 | 9 | 2.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NC(=O)c2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| 10742446 | 213791 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 456 | 9 | 2 | 7 | 2.0 | COCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9147 | 213791 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 456 | 9 | 2 | 7 | 2.0 | COCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 71460535 | 88460 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 693 | 15 | 1 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)CCCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163711 | 88460 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 693 | 15 | 1 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)CCCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 10624915 | 213012 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 490 | 6 | 2 | 6 | 4.5 | COc1ccc(NC(=O)N2C[C@@H](c3ccc4c(c3)OCO4)[C@H](C(=O)O)[C@H]2c2ccc(OC)cc2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL8671 | 213012 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 490 | 6 | 2 | 6 | 4.5 | COc1ccc(NC(=O)N2C[C@@H](c3ccc4c(c3)OCO4)[C@H](C(=O)O)[C@H]2c2ccc(OC)cc2)cc1 | 10.1021/jm9505369 | ||
| 9938571 | 16369 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| CHEMBL112531 | 16369 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| CHEMBL369489 | 16369 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| 9938571 | 16369 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | ||
| CHEMBL112531 | 16369 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | ||
| CHEMBL369489 | 16369 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm0102304 | ||
| 9807691 | 106840 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 553 | 10 | 1 | 10 | 5.3 | COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL287169 | 106840 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 553 | 10 | 1 | 10 | 5.3 | COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| 18617344 | 212057 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 361 | 4 | 1 | 6 | 2.5 | Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL79080 | 212057 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 361 | 4 | 1 | 6 | 2.5 | Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 18617395 | 212051 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 361 | 4 | 1 | 6 | 2.5 | Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL79030 | 212051 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 361 | 4 | 1 | 6 | 2.5 | Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 10789279 | 213344 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 441 | 10 | 1 | 6 | 4.1 | CCCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL8878 | 213344 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 441 | 10 | 1 | 6 | 4.1 | CCCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44327347 | 103538 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 1102 | 26 | 9 | 8 | 7.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1c2ccccc2CCc2ccccc21)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL264579 | 103538 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 1102 | 26 | 9 | 8 | 7.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1c2ccccc2CCc2ccccc21)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 10765171 | 14667 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc(OC)c(OC)c3)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10901 | 14667 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3ccc(OC)c(OC)c3)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| 10503921 | 108253 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1noc(C)c1Cl)OCO2 | 10.1021/jm9700068 | ||
| CHEMBL297783 | 108253 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1noc(C)c1Cl)OCO2 | 10.1021/jm9700068 | ||
| 18617318 | 112390 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 394 | 3 | 1 | 4 | 3.3 | Cc1noc(NS(=O)(=O)c2ccccc2Br)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL312266 | 112390 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 394 | 3 | 1 | 4 | 3.3 | Cc1noc(NS(=O)(=O)c2ccccc2Br)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 44277245 | 113624 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 392 | 6 | 1 | 4 | 3.9 | COc1ccc(Cc2c(C(F)(F)F)[nH]n(Cc3cccc(OC)c3)c2=O)cc1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144736 | 113624 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 392 | 6 | 1 | 4 | 3.9 | COc1ccc(Cc2c(C(F)(F)F)[nH]n(Cc3cccc(OC)c3)c2=O)cc1 | 10.1016/s0960-894x(00)00232-8 | ||
| 16004692 | 9232 | 91 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | ||
| 4809 | 9232 | 91 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | ||
| 7352 | 9232 | 91 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL2103873 | 9232 | 91 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | ||
| DB08932 | 9232 | 91 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | ||
| 16004692 | 9232 | 91 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1021/jm3009103 | ||
| 4809 | 9232 | 91 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1021/jm3009103 | ||
| 7352 | 9232 | 91 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1021/jm3009103 | ||
| CHEMBL2103873 | 9232 | 91 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1021/jm3009103 | ||
| DB08932 | 9232 | 91 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1021/jm3009103 | ||
| 9915510 | 91930 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 549 | 8 | 2 | 8 | 3.4 | CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL22513 | 91930 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 549 | 8 | 2 | 8 | 3.4 | CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1016/s0960-894x(01)00660-6 | ||
| 9915510 | 91930 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 549 | 8 | 2 | 8 | 3.4 | CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL22513 | 91930 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 549 | 8 | 2 | 8 | 3.4 | CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 | 10.1007/s00044-004-0021-y | ||
| 9873255 | 66408 | 0 | None | - | 2 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 591 | 14 | 2 | 10 | 3.8 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL172071 | 66408 | 0 | None | - | 2 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 591 | 14 | 2 | 10 | 3.8 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 10719598 | 213769 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9139 | 213769 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44339655 | 15878 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 530 | 14 | 1 | 6 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| CHEMBL109926 | 15878 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 530 | 14 | 1 | 6 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| 23445254 | 213934 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 412 | 5 | 1 | 5 | 4.2 | Cc1noc(NS(=O)(=O)c2sccc2Cc2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL92318 | 213934 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 412 | 5 | 1 | 5 | 4.2 | Cc1noc(NS(=O)(=O)c2sccc2Cc2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| 10599230 | 213774 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 2.8 | CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9141 | 213774 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 2.8 | CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44314904 | 109924 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 12 | 5 | 5 | 3.6 | CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL307936 | 109924 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 12 | 5 | 5 | 3.6 | CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O | 10.1021/jm9600914 | ||
| 10529868 | 170970 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 516 | 8 | 2 | 6 | 4.8 | CCc1cccc(C)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| CHEMBL421073 | 170970 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 516 | 8 | 2 | 6 | 4.8 | CCc1cccc(C)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| 9917706 | 136517 | 0 | None | - | 2 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 659 | 15 | 2 | 11 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL367444 | 136517 | 0 | None | - | 2 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 659 | 15 | 2 | 11 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/j.bmcl.2016.06.014 | ||
| 44320777 | 212984 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 550 | 10 | 2 | 8 | 4.7 | COc1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL86505 | 212984 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 550 | 10 | 2 | 8 | 4.7 | COc1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| 9897092 | 66710 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 779 | 17 | 2 | 13 | 6.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL173201 | 66710 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 779 | 17 | 2 | 13 | 6.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 9810400 | 105383 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 710 | 14 | 2 | 12 | 5.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL276949 | 105383 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 710 | 14 | 2 | 12 | 5.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 9917706 | 136517 | 0 | None | - | 2 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 659 | 15 | 2 | 11 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL367444 | 136517 | 0 | None | - | 2 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 659 | 15 | 2 | 11 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 10209779 | 170210 | 0 | None | - | 0 | Pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 560 | 14 | 1 | 7 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| CHEMBL419749 | 170210 | 0 | None | - | 0 | Pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 560 | 14 | 1 | 7 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| 44314659 | 211899 | 0 | None | - | 0 | Pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 631 | 12 | 5 | 4 | 4.5 | C=CCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL77853 | 211899 | 0 | None | - | 0 | Pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 631 | 12 | 5 | 4 | 4.5 | C=CCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 9894460 | 213488 | 9 | None | -41 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm970101g | ||
| CHEMBL313871 | 213488 | 9 | None | -41 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm970101g | ||
| CHEMBL8978 | 213488 | 9 | None | -41 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm970101g | ||
| 10303555 | 170160 | 0 | None | - | 0 | Pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 574 | 15 | 1 | 7 | 4.9 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| CHEMBL419383 | 170160 | 0 | None | - | 0 | Pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 574 | 15 | 1 | 7 | 4.9 | CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| 1009 | 6982 | 25 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL5210307 | ||
| 5310991 | 6982 | 25 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL5210307 | ||
| CHEMBL332794 | 6982 | 25 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.6019/CHEMBL5210307 | ||
| 44315009 | 109983 | 0 | None | - | 0 | Pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 665 | 13 | 5 | 5 | 4.7 | CSCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL308403 | 109983 | 0 | None | - | 0 | Pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 665 | 13 | 5 | 5 | 4.7 | CSCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 44314675 | 104904 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 13 | 5 | 4 | 5.0 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)CC)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL273583 | 104904 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 13 | 5 | 4 | 5.0 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)CC)C(=O)O | 10.1021/jm9600914 | ||
| 44314676 | 109701 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 589 | 12 | 5 | 4 | 4.6 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL306171 | 109701 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 589 | 12 | 5 | 4 | 4.6 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1021/jm9600914 | ||
| 17885919 | 213189 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 526 | 9 | 2 | 8 | 4.8 | O=C(O)COc1ccccc1Cn1nc(-c2cccs2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL87801 | 213189 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 526 | 9 | 2 | 8 | 4.8 | O=C(O)COc1ccccc1Cn1nc(-c2cccs2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O | 10.1016/s0960-894x(00)00513-8 | ||
| 44320171 | 113734 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 504 | 6 | 1 | 5 | 6.4 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC12CC3CC(CC(C3)C1)C2 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL314974 | 113734 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 504 | 6 | 1 | 5 | 6.4 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC12CC3CC(CC(C3)C1)C2 | 10.1016/s0960-894x(00)00513-8 | ||
| 10252787 | 106042 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 442 | 7 | 1 | 6 | 4.6 | COc1cccc(Cn2nc(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL281865 | 106042 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 442 | 7 | 1 | 6 | 4.6 | COc1cccc(Cn2nc(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL1790519 | 215672 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N(C)[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC | 10.1021/jm970161m | ||||
| 10648937 | 214085 | 0 | None | - | 0 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9334 | 214085 | 0 | None | - | 0 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44327466 | 103226 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 966 | 25 | 9 | 8 | 5.2 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(C)(C)C)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL262229 | 103226 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 966 | 25 | 9 | 8 | 5.2 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(C)(C)C)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 11103152 | 170019 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 504 | 9 | 1 | 7 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)c(OC)c1)O2 | 10.1021/jm010382z | ||
| CHEMBL418473 | 170019 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 504 | 9 | 1 | 7 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)c(OC)c1)O2 | 10.1021/jm010382z | ||
| 10364227 | 209578 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL62264 | 209578 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 11059349 | 210288 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 446 | 6 | 1 | 6 | 4.8 | CCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL66264 | 210288 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 446 | 6 | 1 | 6 | 4.8 | CCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 44298279 | 201730 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 502 | 10 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(C)=O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL54274 | 201730 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 502 | 10 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(C)=O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 10239569 | 21560 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 534 | 9 | 1 | 10 | 4.4 | COc1cc(C/C(C(=O)c2ccc3c(c2)OCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1206715 | 21560 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 534 | 9 | 1 | 10 | 4.4 | COc1cc(C/C(C(=O)c2ccc3c(c2)OCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL299328 | 21560 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 534 | 9 | 1 | 10 | 4.4 | COc1cc(C/C(C(=O)c2ccc3c(c2)OCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| 10364227 | 209578 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm031041j | ||
| CHEMBL62264 | 209578 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm031041j | ||
| 18617355 | 211733 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL76438 | 211733 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/0960-894X(96)00441-6 | ||
| 11026419 | 209961 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 4.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3c(OC)cccc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL64266 | 209961 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 4.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3c(OC)cccc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL2370070 | 216558 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | ||||
| CHEMBL315047 | 217965 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | ||||
| 10718385 | 213590 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 2.4 | C#CCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9040 | 213590 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 2.4 | C#CCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 10550844 | 104084 | 0 | None | - | 0 | Pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 435 | 5 | 1 | 6 | 3.7 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)c2ccco2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL269140 | 104084 | 0 | None | - | 0 | Pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 435 | 5 | 1 | 6 | 3.7 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)c2ccco2)cc1 | 10.1021/jm9505369 | ||
| 10553316 | 103851 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL267279 | 103851 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 10205245 | 78984 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 466 | 5 | 2 | 9 | 3.4 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2C#N)OCO3)c1Cl | 10.1021/jm9608366 | ||
| CHEMBL19808 | 78984 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 466 | 5 | 2 | 9 | 3.4 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2C#N)OCO3)c1Cl | 10.1021/jm9608366 | ||
| 44291575 | 186214 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 466 | 5 | 2 | 9 | 3.4 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2C#N)OCO3)c1Cl | 10.1021/jm9700068 | ||
| CHEMBL47404 | 186214 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 466 | 5 | 2 | 9 | 3.4 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2C#N)OCO3)c1Cl | 10.1021/jm9700068 | ||
| 137642741 | 165018 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 553 | 9 | 2 | 9 | 4.2 | CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4088349 | 165018 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 553 | 9 | 2 | 9 | 4.2 | CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 10005597 | 126596 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL348407 | 126596 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| 10531650 | 175040 | 0 | None | - | 0 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 600 | 11 | 1 | 7 | 5.0 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(Cl)cc1 | 10.1021/jm970101g | ||
| CHEMBL433842 | 175040 | 0 | None | - | 0 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 600 | 11 | 1 | 7 | 5.0 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(Cl)cc1 | 10.1021/jm970101g | ||
| 9852318 | 16386 | 8 | None | - | 2 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL112624 | 16386 | 8 | None | - | 2 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL1627022 | 16386 | 8 | None | - | 2 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 10578320 | 104085 | 0 | None | - | 0 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 538 | 12 | 1 | 6 | 5.2 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CCC(C)C)CCC(C)C)cc1 | 10.1021/jm9505369 | ||
| CHEMBL269141 | 104085 | 0 | None | - | 0 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 538 | 12 | 1 | 6 | 5.2 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CCC(C)C)CCC(C)C)cc1 | 10.1021/jm9505369 | ||
| 10917653 | 210156 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 468 | 11 | 1 | 6 | 6.1 | CCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL65292 | 210156 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 468 | 11 | 1 | 6 | 6.1 | CCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 9821701 | 11384 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 389 | 4 | 1 | 5 | 3.8 | COc1ccc([C@@H]2c3ncccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL102825 | 11384 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 389 | 4 | 1 | 5 | 3.8 | COc1ccc([C@@H]2c3ncccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| 10767586 | 16541 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 13 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL113529 | 16541 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 13 | 1 | 5 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 10602183 | 16011 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 525 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1ccccc1=O | 10.1021/jm980217s | ||
| CHEMBL110695 | 16011 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 525 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1ccccc1=O | 10.1021/jm980217s | ||
| 44383537 | 66023 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 388 | 4 | 2 | 5 | 3.4 | C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 | 10.1016/s0960-894x(00)00136-0 | ||
| CHEMBL170335 | 66023 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 388 | 4 | 2 | 5 | 3.4 | C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 | 10.1016/s0960-894x(00)00136-0 | ||
| 23445430 | 67840 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 438 | 5 | 1 | 5 | 5.1 | Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL176422 | 67840 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 438 | 5 | 1 | 5 | 5.1 | Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00133-9 | ||
| 44384652 | 68059 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 582 | 8 | 1 | 9 | 5.2 | Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2COC2CCOCC2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL176675 | 68059 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 582 | 8 | 1 | 9 | 5.2 | Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2COC2CCOCC2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| 155519384 | 177197 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 674 | 12 | 1 | 13 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4448273 | 177197 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 674 | 12 | 1 | 13 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 71458719 | 88453 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 647 | 15 | 1 | 13 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(SC)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163704 | 88453 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 647 | 15 | 1 | 13 | 4.7 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(SC)cn1 | 10.1021/jm3009103 | ||
| 10146640 | 214333 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 689 | 12 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL94786 | 214333 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 689 | 12 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 | 10.1016/s0960-894x(02)01084-3 | ||
| 10366278 | 179243 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 446 | 6 | 2 | 6 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL448165 | 179243 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 446 | 6 | 2 | 6 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| 44278215 | 106334 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 491 | 5 | 1 | 9 | 4.7 | O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL283598 | 106334 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 491 | 5 | 1 | 9 | 4.7 | O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 | 10.1016/0960-894X(96)00232-6 | ||
| 18995986 | 106357 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 537 | 8 | 1 | 10 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL283858 | 106357 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 537 | 8 | 1 | 10 | 5.0 | COc1ccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC | 10.1016/0960-894X(96)00232-6 | ||
| 44270522 | 52580 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 744 | 15 | 1 | 10 | 8.2 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL15310 | 52580 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 744 | 15 | 1 | 10 | 8.2 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| 44284183 | 146353 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 518 | 9 | 2 | 7 | 5.7 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCC(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL37973 | 146353 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 518 | 9 | 2 | 7 | 5.7 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCC(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 44386069 | 66509 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 704 | 13 | 2 | 11 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL172441 | 66509 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 704 | 13 | 2 | 11 | 5.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 44291495 | 18005 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 455 | 6 | 2 | 9 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2/C(Cc2ccc3c(c2)OCO3)=N\O)c1Cl | 10.1021/jm9700068 | ||
| CHEMBL1178832 | 18005 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 455 | 6 | 2 | 9 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2/C(Cc2ccc3c(c2)OCO3)=N\O)c1Cl | 10.1021/jm9700068 | ||
| CHEMBL45351 | 18005 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 455 | 6 | 2 | 9 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2/C(Cc2ccc3c(c2)OCO3)=N\O)c1Cl | 10.1021/jm9700068 | ||
| 44213923 | 115058 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 563 | 8 | 1 | 8 | 4.1 | COc1ccc(C2=NN(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)C(=O)CC2)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL319743 | 115058 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 563 | 8 | 1 | 8 | 4.1 | COc1ccc(C2=NN(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)C(=O)CC2)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| 11799440 | 213755 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCN(CCC)C(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9132 | 213755 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 11 | 1 | 6 | 4.3 | CCCN(CCC)C(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 10506868 | 70031 | 0 | None | - | 0 | Pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 550 | 10 | 5 | 5 | 4.7 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL179138 | 70031 | 0 | None | - | 0 | Pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 550 | 10 | 5 | 5 | 4.7 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| 10553384 | 116445 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 498 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 | 10.1021/jm980217s | ||
| CHEMBL322537 | 116445 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 498 | 13 | 1 | 7 | 3.6 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 | 10.1021/jm980217s | ||
| 76308472 | 92129 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 517 | 6 | 1 | 8 | 3.7 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C#N)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261600 | 92129 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 517 | 6 | 1 | 8 | 3.7 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C#N)ccc12 | 10.1007/s00044-004-0021-y | ||
| 71451527 | 88455 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 641 | 15 | 1 | 12 | 4.8 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C2CC2)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163706 | 88455 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 641 | 15 | 1 | 12 | 4.8 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C2CC2)cn1 | 10.1021/jm3009103 | ||
| 23445313 | 172416 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 470 | 6 | 1 | 6 | 5.1 | Cc1cc(C)c(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL424371 | 172416 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 470 | 6 | 1 | 6 | 5.1 | Cc1cc(C)c(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00132-7 | ||
| 23445421 | 66704 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 5.0 | Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL173189 | 66704 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 5.0 | Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00133-9 | ||
| 11005242 | 209674 | 0 | None | - | 0 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 | 10.1021/jm010382z | ||
| CHEMBL62719 | 209674 | 0 | None | - | 0 | Pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 | 10.1021/jm010382z | ||
| 44212539 | 210872 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 671 | 12 | 2 | 12 | 5.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL70203 | 210872 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 671 | 12 | 2 | 12 | 5.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 44284288 | 106911 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 559 | 9 | 2 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL287683 | 106911 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 559 | 9 | 2 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 44284266 | 143710 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 531 | 8 | 2 | 7 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CN(C)C(C)=O)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL37427 | 143710 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 531 | 8 | 2 | 7 | 4.6 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CN(C)C(C)=O)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 44212539 | 210872 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 671 | 12 | 2 | 12 | 5.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70203 | 210872 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 671 | 12 | 2 | 12 | 5.9 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 44371449 | 56152 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c(OC)c1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL156404 | 56152 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c(OC)c1 | 10.1016/s0960-894x(99)00040-2 | ||
| 44298278 | 201446 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 462 | 8 | 2 | 7 | 4.5 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCO)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL53168 | 201446 | 0 | None | - | 0 | Pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 462 | 8 | 2 | 7 | 4.5 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCO)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 44371670 | 148441 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 1082 | 23 | 11 | 10 | 3.7 | CC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C1c2ccccc2CCc2ccccc21 | 10.1016/0960-894X(95)00084-7 | ||
| CHEMBL385405 | 148441 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 1082 | 23 | 11 | 10 | 3.7 | CC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C1c2ccccc2CCc2ccccc21 | 10.1016/0960-894X(95)00084-7 | ||
| CHEMBL432091 | 220411 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | ||||
| CHEMBL432091 | 220411 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00152-J | ||||
| 10792785 | 173502 | 0 | None | - | 0 | Pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 551 | 10 | 3 | 6 | 5.0 | CCOC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C | 10.1021/jm950592+ | ||
| CHEMBL428298 | 173502 | 0 | None | - | 0 | Pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 551 | 10 | 3 | 6 | 5.0 | CCOC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C | 10.1021/jm950592+ | ||
| 23445221 | 209874 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 470 | 5 | 1 | 7 | 4.4 | Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00367-3 | ||
| CHEMBL63937 | 209874 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 470 | 5 | 1 | 7 | 4.4 | Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00367-3 | ||
| 10529742 | 14964 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 511 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1cccn1C | 10.1021/jm980217s | ||
| CHEMBL109206 | 14964 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 511 | 13 | 1 | 6 | 4.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1cccn1C | 10.1021/jm980217s | ||
| 10672494 | 186332 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 483 | 6 | 2 | 6 | 5.0 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)C)cc2)c1Br | 10.1021/jm9608366 | ||
| CHEMBL47417 | 186332 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 483 | 6 | 2 | 6 | 5.0 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)C)cc2)c1Br | 10.1021/jm9608366 | ||
| 23445354 | 213414 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 426 | 5 | 1 | 5 | 4.8 | CCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL89203 | 213414 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 426 | 5 | 1 | 5 | 4.8 | CCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | ||
| 52944276 | 25201 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 559 | 11 | 3 | 8 | 4.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCCO)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| CHEMBL1271807 | 25201 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 559 | 11 | 3 | 8 | 4.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCCO)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| 10674642 | 120147 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 574 | 10 | 3 | 7 | 4.7 | CCc1cc(C(=O)O)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| CHEMBL331758 | 120147 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 574 | 10 | 3 | 7 | 4.7 | CCc1cc(C(=O)O)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| 44320291 | 112715 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 548 | 7 | 2 | 8 | 4.8 | O=C(O)c1cc2c(c(Cn3nc(-c4ccccc4)c(Cc4cc5c(cc4Cl)OCO5)c3C(=O)O)c1)OCOC2 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL312854 | 112715 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 548 | 7 | 2 | 8 | 4.8 | O=C(O)c1cc2c(c(Cn3nc(-c4ccccc4)c(Cc4cc5c(cc4Cl)OCO5)c3C(=O)O)c1)OCOC2 | 10.1016/s0960-894x(00)00513-8 | ||
| 10281573 | 66749 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 4.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccncc2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL173358 | 66749 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 4.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccncc2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| 9939960 | 182354 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 704 | 13 | 2 | 11 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)cc(C(=O)N2CCN(C)CC2)cc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4579445 | 182354 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 704 | 13 | 2 | 11 | 5.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)cc(C(=O)N2CCN(C)CC2)cc1OCCOC(=O)Nc1ccccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 44320444 | 213222 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 481 | 7 | 2 | 8 | 4.0 | O=C(O)c1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)on1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL88019 | 213222 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 481 | 7 | 2 | 8 | 4.0 | O=C(O)c1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)on1 | 10.1016/s0960-894x(00)00513-8 | ||
| 44309897 | 211410 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 469 | 5 | 1 | 7 | 4.9 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4c(c3)OCO4)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(97)10151-2 | ||
| CHEMBL73506 | 211410 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 469 | 5 | 1 | 7 | 4.9 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4c(c3)OCO4)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(97)10151-2 | ||
| 9936145 | 25799 | 2 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 510 | 11 | 1 | 4 | 5.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 | 10.1021/jm010237l | ||
| CHEMBL128818 | 25799 | 2 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 510 | 11 | 1 | 4 | 5.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 | 10.1021/jm010237l | ||
| 44327890 | 148190 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 985 | 26 | 9 | 8 | 5.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL384052 | 148190 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 985 | 26 | 9 | 8 | 5.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 44266537 | 11100 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 507 | 8 | 1 | 6 | 6.4 | COc1ccc(Cn2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)ccc32)cc1 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL10092 | 11100 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 507 | 8 | 1 | 6 | 6.4 | COc1ccc(Cn2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)ccc32)cc1 | 10.1016/0960-894X(96)00170-9 | ||
| 71462320 | 88779 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 570 | 11 | 2 | 8 | 3.9 | Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL2165332 | 88779 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 570 | 11 | 2 | 8 | 3.9 | Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 71462320 | 88779 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 570 | 11 | 2 | 8 | 3.9 | Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2165332 | 88779 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 570 | 11 | 2 | 8 | 3.9 | Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm3009103 | ||
| 10674176 | 169479 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 548 | 11 | 1 | 9 | 5.0 | CCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OCC)c1OCC | 10.1021/jm9606507 | ||
| CHEMBL417067 | 169479 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 548 | 11 | 1 | 9 | 5.0 | CCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OCC)c1OCC | 10.1021/jm9606507 | ||
| 18184256 | 136261 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 662 | 13 | 2 | 13 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL367275 | 136261 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 662 | 13 | 2 | 13 | 3.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 10740439 | 179527 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 412 | 5 | 2 | 7 | 3.5 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)nc1 | 10.1021/jm9608366 | ||
| CHEMBL45087 | 179527 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 412 | 5 | 2 | 7 | 3.5 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)nc1 | 10.1021/jm9608366 | ||
| 23445379 | 136877 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 456 | 6 | 1 | 6 | 4.8 | Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL367776 | 136877 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 456 | 6 | 1 | 6 | 4.8 | Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL407422 | 219440 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(96)00127-8 | ||||
| 44284184 | 146778 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 490 | 8 | 2 | 7 | 5.0 | CCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL38000 | 146778 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 490 | 8 | 2 | 7 | 5.0 | CCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL409433 | 219542 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(96)00127-8 | ||||
| 44458399 | 105768 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 520 | 7 | 2 | 7 | 4.2 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL279947 | 105768 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 520 | 7 | 2 | 7 | 4.2 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL313382 | 217892 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| CHEMBL87243 | 222672 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00070a001 | ||||
| 10288713 | 108820 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 4.6 | CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | ||
| CHEMBL301840 | 108820 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 4.6 | CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | ||
| 10160887 | 106924 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 447 | 5 | 1 | 7 | 5.0 | O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL28779 | 106924 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 447 | 5 | 1 | 7 | 5.0 | O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00232-6 | ||
| 10600668 | 11930 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1cc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc(OC)c1OC | 10.1021/jm9606507 | ||
| CHEMBL10589 | 11930 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1cc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc(OC)c1OC | 10.1021/jm9606507 | ||
| 10840410 | 210839 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 550 | 10 | 2 | 10 | 3.3 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCC(=O)O)c2)cc1 | 10.1021/jm980504w | ||
| CHEMBL70017 | 210839 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 550 | 10 | 2 | 10 | 3.3 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCC(=O)O)c2)cc1 | 10.1021/jm980504w | ||
| 44327237 | 214708 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 511 | 8 | 1 | 8 | 3.5 | CCCc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL96847 | 214708 | 0 | None | - | 0 | Pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 511 | 8 | 1 | 8 | 3.5 | CCCc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| 18617327 | 212035 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1ccccc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL78929 | 212035 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1ccccc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 44439108 | 173893 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 1267 | 53 | 3 | 22 | 5.7 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 | 10.1016/j.bmcl.2006.10.009 | ||
| CHEMBL429019 | 173893 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 1267 | 53 | 3 | 22 | 5.7 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 | 10.1016/j.bmcl.2006.10.009 | ||
| 22010352 | 124404 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 404 | 10 | 1 | 4 | 5.5 | CC(=O)c1ccc(OCc2ccccc2)cc1OC(CCC(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | ||
| CHEMBL3400984 | 124404 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 404 | 10 | 1 | 4 | 5.5 | CC(=O)c1ccc(OCc2ccccc2)cc1OC(CCC(=O)O)c1ccccc1 | 10.1016/j.bmc.2015.01.003 | ||
| 44339655 | 15878 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 530 | 14 | 1 | 6 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| CHEMBL109926 | 15878 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 530 | 14 | 1 | 6 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| 11742628 | 105011 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL274383 | 105011 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 5 | 1 | 6 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| 9845967 | 17865 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1016/S0960-894X(97)00002-4 | ||
| CHEMBL10801 | 17865 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1016/S0960-894X(97)00002-4 | ||
| CHEMBL1178000 | 17865 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1016/S0960-894X(97)00002-4 | ||
| CHEMBL51530 | 17865 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1016/S0960-894X(97)00002-4 | ||
| 9845967 | 17865 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL10801 | 17865 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1178000 | 17865 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL51530 | 17865 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 7 | 1 | 5 | 4.4 | COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| 71455064 | 88471 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 694 | 14 | 1 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)N(C)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163721 | 88471 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 694 | 14 | 1 | 12 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)N(C)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 71460621 | 88776 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 602 | 13 | 2 | 10 | 3.7 | COc1cccc(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1021/jm3009103 | ||
| CHEMBL2165329 | 88776 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 602 | 13 | 2 | 10 | 3.7 | COc1cccc(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1021/jm3009103 | ||
| 10527706 | 103776 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 454 | 8 | 1 | 6 | 3.1 | CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL266594 | 103776 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 454 | 8 | 1 | 6 | 3.1 | CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44386002 | 67070 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 503 | 9 | 1 | 9 | 3.9 | C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL174326 | 67070 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 503 | 9 | 1 | 9 | 3.9 | C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 11015826 | 210310 | 0 | None | - | 0 | Pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 6.1 | CC(C)Oc1ccc2c(c1)C(CC1CCCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL66426 | 210310 | 0 | None | - | 0 | Pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 6.1 | CC(C)Oc1ccc2c(c1)C(CC1CCCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 10626646 | 23218 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCc1cccc(CCC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| CHEMBL123305 | 23218 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCc1cccc(CCC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| 10240093 | 88462 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 603 | 12 | 1 | 12 | 3.5 | CCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| CHEMBL2163713 | 88462 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 603 | 12 | 1 | 12 | 3.5 | CCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| 44295224 | 21403 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 532 | 9 | 1 | 9 | 4.6 | COc1cc(C/C(C(=O)c2ccc3c(c2)CCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1205077 | 21403 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 532 | 9 | 1 | 9 | 4.6 | COc1cc(C/C(C(=O)c2ccc3c(c2)CCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL49675 | 21403 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 532 | 9 | 1 | 9 | 4.6 | COc1cc(C/C(C(=O)c2ccc3c(c2)CCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL316092 | 217974 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00070a001 | ||||
| 15453209 | 211910 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 358 | 3 | 1 | 4 | 3.5 | Cc1cc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL77962 | 211910 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 358 | 3 | 1 | 4 | 3.5 | Cc1cc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/0960-894X(96)00441-6 | ||
| 71451526 | 88450 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 635 | 14 | 1 | 12 | 4.6 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Cl)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163701 | 88450 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 635 | 14 | 1 | 12 | 4.6 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Cl)cn1 | 10.1021/jm3009103 | ||
| 67952994 | 88781 | 14 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 634 | 11 | 2 | 8 | 4.4 | O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2165334 | 88781 | 14 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 634 | 11 | 2 | 8 | 4.4 | O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| 10145418 | 88447 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 601 | 14 | 1 | 12 | 4.0 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL2163698 | 88447 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 601 | 14 | 1 | 12 | 4.0 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 10145418 | 88447 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 601 | 14 | 1 | 12 | 4.0 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 | 10.1021/jm3009103 | ||
| CHEMBL2163698 | 88447 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 601 | 14 | 1 | 12 | 4.0 | COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 | 10.1021/jm3009103 | ||
| 44386163 | 67154 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 577 | 14 | 2 | 10 | 3.4 | CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL174781 | 67154 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 577 | 14 | 2 | 10 | 3.4 | CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 71453356 | 88440 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 554 | 13 | 2 | 10 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cccc(OC)c1 | 10.1021/jm3009103 | ||
| CHEMBL2163691 | 88440 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 554 | 13 | 2 | 10 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cccc(OC)c1 | 10.1021/jm3009103 | ||
| 44439106 | 160386 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 1005 | 37 | 2 | 17 | 5.8 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 | 10.1016/j.bmcl.2006.10.009 | ||
| CHEMBL398070 | 160386 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 1005 | 37 | 2 | 17 | 5.8 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 | 10.1016/j.bmcl.2006.10.009 | ||
| 10579100 | 173120 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 578 | 10 | 2 | 6 | 5.4 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL122614 | 173120 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 578 | 10 | 2 | 6 | 5.4 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL427303 | 173120 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 578 | 10 | 2 | 6 | 5.4 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| 10006086 | 127840 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 498 | 9 | 2 | 5 | 4.6 | COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL356916 | 127840 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 498 | 9 | 2 | 5 | 4.6 | COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL414131 | 219892 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(96)00127-8 | ||||
| 11059249 | 109395 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 440 | 10 | 1 | 6 | 5.3 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCCC)cc21 | 10.1021/jm010382z | ||
| CHEMBL304202 | 109395 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 440 | 10 | 1 | 6 | 5.3 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCCC)cc21 | 10.1021/jm010382z | ||
| 11733231 | 209623 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)c1 | 10.1021/jm010382z | ||
| CHEMBL62465 | 209623 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 460 | 6 | 1 | 6 | 5.2 | COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)c1 | 10.1021/jm010382z | ||
| CHEMBL431433 | 220404 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | ||||
| 18617340 | 112180 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 4 | 1 | 4 | 3.9 | CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL311742 | 112180 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 4 | 1 | 4 | 3.9 | CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/0960-894X(96)00441-6 | ||
| 44279439 | 114155 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 534 | 3 | 2 | 3 | 6.2 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL31781 | 114155 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 534 | 3 | 2 | 3 | 6.2 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL303204 | 217697 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00089a028 | ||||
| 44317005 | 211805 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 320 | 3 | 1 | 4 | 3.4 | Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL76949 | 211805 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 320 | 3 | 1 | 4 | 3.4 | Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 10116355 | 15038 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 474 | 14 | 1 | 5 | 4.9 | CCCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| CHEMBL109248 | 15038 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 474 | 14 | 1 | 5 | 4.9 | CCCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| 11799503 | 16525 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 498 | 13 | 1 | 6 | 4.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccco1 | 10.1021/jm980217s | ||
| CHEMBL113472 | 16525 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 498 | 13 | 1 | 6 | 4.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccco1 | 10.1021/jm980217s | ||
| 10095637 | 56741 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL15689 | 56741 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00186-W | ||
| 44459247 | 94798 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 575 | 8 | 1 | 7 | 4.9 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)N(C)C)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL23444 | 94798 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 575 | 8 | 1 | 7 | 4.9 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)N(C)C)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| 10649546 | 115391 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 516 | 13 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCCO1 | 10.1021/jm980217s | ||
| CHEMBL320569 | 115391 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 516 | 13 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCCO1 | 10.1021/jm980217s | ||
| 44284405 | 107132 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 532 | 10 | 2 | 7 | 5.4 | COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL289634 | 107132 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 532 | 10 | 2 | 7 | 5.4 | COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | 10.1016/j.bmcl.2004.01.008 | ||
| 9870830 | 213493 | 38 | None | -66 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/S0960-894X(97)00002-4 | ||
| CHEMBL8981 | 213493 | 38 | None | -66 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/S0960-894X(97)00002-4 | ||
| 10971938 | 209755 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 7 | 1 | 5 | 5.6 | CC(C)CCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL63058 | 209755 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 7 | 1 | 5 | 5.6 | CC(C)CCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 44295156 | 21399 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1205062 | 21399 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL48411 | 21399 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 520 | 10 | 1 | 9 | 4.7 | COc1ccccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 | 10.1016/s0960-894x(98)00301-1 | ||
| 44284199 | 106886 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 552 | 9 | 2 | 7 | 6.2 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL287517 | 106886 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 552 | 9 | 2 | 7 | 6.2 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 10961277 | 107794 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 446 | 5 | 2 | 6 | 4.9 | CC(C)Oc1ccc2c(c1)C(c1ccc(O)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL294496 | 107794 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 446 | 5 | 2 | 6 | 4.9 | CC(C)Oc1ccc2c(c1)C(c1ccc(O)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 10788494 | 177402 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 424 | 6 | 1 | 6 | 4.5 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9700068 | ||
| CHEMBL445101 | 177402 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 424 | 6 | 1 | 6 | 4.5 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1021/jm9700068 | ||
| CHEMBL133257 | 215494 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | ||||
| 44339840 | 16060 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 486 | 13 | 1 | 5 | 5.1 | C/C=C(\C)CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| CHEMBL110904 | 16060 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 486 | 13 | 1 | 5 | 5.1 | C/C=C(\C)CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| 10816110 | 115343 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 532 | 13 | 1 | 7 | 4.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OC(C)C(C)O1 | 10.1021/jm980217s | ||
| CHEMBL320254 | 115343 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 532 | 13 | 1 | 7 | 4.2 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OC(C)C(C)O1 | 10.1021/jm980217s | ||
| 10530156 | 16329 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 526 | 14 | 1 | 6 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL112347 | 16329 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 526 | 14 | 1 | 6 | 5.0 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 10579210 | 175370 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 585 | 10 | 4 | 6 | 5.4 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCc3ccccc32)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL435901 | 175370 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 585 | 10 | 4 | 6 | 5.4 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCc3ccccc32)nc1C(=O)O | 10.1021/jm950592+ | ||
| 10673969 | 68879 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 538 | 10 | 3 | 7 | 5.0 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| CHEMBL177546 | 68879 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 538 | 10 | 3 | 7 | 5.0 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| 22998414 | 209795 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 422 | 5 | 1 | 9 | 3.1 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1C | 10.1016/S0960-894X(97)00367-3 | ||
| CHEMBL63290 | 209795 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 422 | 5 | 1 | 9 | 3.1 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1C | 10.1016/S0960-894X(97)00367-3 | ||
| 10231591 | 138138 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 569 | 10 | 2 | 11 | 2.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL368828 | 138138 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 569 | 10 | 2 | 11 | 2.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| 44311232 | 210886 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 658 | 13 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70293 | 210886 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 658 | 13 | 2 | 13 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 18995989 | 107331 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 583 | 9 | 1 | 9 | 6.6 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL29147 | 107331 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 583 | 9 | 1 | 9 | 6.6 | COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 | 10.1016/0960-894X(96)00232-6 | ||
| 10426645 | 169854 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 328 | 4 | 1 | 4 | 3.8 | Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL417651 | 169854 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 328 | 4 | 1 | 4 | 3.8 | Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 11728313 | 170054 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 368 | 6 | 1 | 5 | 4.2 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | ||
| CHEMBL418667 | 170054 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 368 | 6 | 1 | 5 | 4.2 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 | 10.1021/jm010382z | ||
| 44368396 | 51366 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 506 | 8 | 2 | 5 | 4.9 | COc1ccc(C(=O)N(Cc2cc3c(cc2Cl)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL152017 | 51366 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 506 | 8 | 2 | 5 | 4.9 | COc1ccc(C(=O)N(Cc2cc3c(cc2Cl)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| 10357554 | 104340 | 1 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 302 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL27065 | 104340 | 1 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 302 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 44316973 | 212384 | 2 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL81593 | 212384 | 2 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 330 | 3 | 1 | 4 | 2.9 | Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 44439114 | 168409 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 993 | 32 | 2 | 15 | 7.3 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CCC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 | 10.1016/j.bmcl.2006.10.009 | ||
| CHEMBL413001 | 168409 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 993 | 32 | 2 | 15 | 7.3 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CCC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 | 10.1016/j.bmcl.2006.10.009 | ||
| 10812400 | 105155 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 427 | 9 | 1 | 6 | 3.7 | CCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL275306 | 105155 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 427 | 9 | 1 | 6 | 3.7 | CCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 10816667 | 18216 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 558 | 9 | 2 | 6 | 5.6 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL1180341 | 18216 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 558 | 9 | 2 | 6 | 5.6 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL122933 | 18216 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 558 | 9 | 2 | 6 | 5.6 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)(C)C)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| 10768903 | 18906 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 544 | 11 | 2 | 6 | 5.3 | CCCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| CHEMBL1184133 | 18906 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 544 | 11 | 2 | 6 | 5.3 | CCCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| CHEMBL334076 | 18906 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 544 | 11 | 2 | 6 | 5.3 | CCCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| 44314579 | 109694 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL306123 | 109694 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 580 | 12 | 5 | 5 | 3.8 | CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1021/jm9600914 | ||
| 44314722 | 162530 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 597 | 14 | 5 | 4 | 4.9 | CCCCC(NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL405724 | 162530 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 597 | 14 | 5 | 4 | 4.9 | CCCCC(NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 44283421 | 106933 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 597 | 14 | 5 | 4 | 4.9 | CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| CHEMBL287888 | 106933 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 597 | 14 | 5 | 4 | 4.9 | CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| 9809919 | 211188 | 0 | None | - | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL72037 | 211188 | 0 | None | - | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 665 | 13 | 2 | 13 | 4.5 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 10209320 | 16057 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 546 | 12 | 1 | 7 | 4.0 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC(C)C | 10.1021/jm970101g | ||
| CHEMBL110899 | 16057 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 546 | 12 | 1 | 7 | 4.0 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC(C)C | 10.1021/jm970101g | ||
| 10579303 | 16203 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 590 | 16 | 1 | 8 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCOC)cc1 | 10.1021/jm970101g | ||
| CHEMBL111712 | 16203 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 590 | 16 | 1 | 8 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCOC)cc1 | 10.1021/jm970101g | ||
| 44314864 | 109813 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 566 | 11 | 5 | 5 | 3.4 | CCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL307077 | 109813 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 566 | 11 | 5 | 5 | 3.4 | CCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O | 10.1021/jm9600914 | ||
| 44314751 | 168134 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 13 | 5 | 4 | 5.0 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL412602 | 168134 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 13 | 5 | 4 | 5.0 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 44283349 | 107102 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 13 | 5 | 4 | 5.0 | CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| CHEMBL289410 | 107102 | 0 | None | - | 0 | Pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 13 | 5 | 4 | 5.0 | CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1016/0960-894X(95)00237-N | ||
| 44284437 | 106760 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 520 | 9 | 4 | 8 | 3.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL286621 | 106760 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 520 | 9 | 4 | 8 | 3.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 10506430 | 120567 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 9 | 2 | 7 | 4.5 | CCc1cccc(OC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| CHEMBL332387 | 120567 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 9 | 2 | 7 | 4.5 | CCc1cccc(OC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| CHEMBL313984 | 217902 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | ||||
| 10188517 | 68540 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 582 | 9 | 2 | 10 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL177203 | 68540 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 582 | 9 | 2 | 10 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| 9850566 | 10966 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 551 | 8 | 1 | 8 | 6.1 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL10016 | 10966 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 551 | 8 | 1 | 8 | 6.1 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 | 10.1016/0960-894X(96)00170-9 | ||
| 44298305 | 201367 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 504 | 10 | 2 | 7 | 5.3 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(=O)O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL53097 | 201367 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 504 | 10 | 2 | 7 | 5.3 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(=O)O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 44298277 | 201778 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 474 | 9 | 1 | 7 | 5.1 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC=O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL54773 | 201778 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 474 | 9 | 1 | 7 | 5.1 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC=O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 44298988 | 107495 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | ||
| CHEMBL292580 | 107495 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | ||
| 3911 | 10090 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00296-5 | ||||
| CHEMBL429908 | 10090 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00296-5 | ||||
| CHEMBL329609 | 218097 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 10649266 | 16404 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL112685 | 16404 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 22010244 | 213580 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 9 | 1 | 5 | 5.5 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N | 10.1021/jm9707131 | ||
| CHEMBL90320 | 213580 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 9 | 1 | 5 | 5.5 | Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N | 10.1021/jm9707131 | ||
| 10649585 | 116550 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 518 | 14 | 1 | 7 | 3.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC1OCCO1 | 10.1021/jm980217s | ||
| CHEMBL323175 | 116550 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 518 | 14 | 1 | 7 | 3.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC1OCCO1 | 10.1021/jm980217s | ||
| 44383592 | 66676 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 386 | 4 | 1 | 5 | 3.6 | C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(=O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 | 10.1016/s0960-894x(00)00136-0 | ||
| CHEMBL173059 | 66676 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 386 | 4 | 1 | 5 | 3.6 | C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(=O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 | 10.1016/s0960-894x(00)00136-0 | ||
| 44265853 | 213181 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 454 | 4 | 1 | 6 | 2.7 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)N2CCOCC2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL8776 | 213181 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 454 | 4 | 1 | 6 | 2.7 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)N2CCOCC2)cc1 | 10.1021/jm9505369 | ||
| 21979593 | 88780 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 590 | 11 | 2 | 8 | 4.3 | O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2165333 | 88780 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 590 | 11 | 2 | 8 | 4.3 | O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 | 10.1021/jm3009103 | ||
| 71455139 | 88778 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 556 | 11 | 2 | 8 | 3.6 | O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccccc1 | 10.1021/jm3009103 | ||
| CHEMBL2165331 | 88778 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 556 | 11 | 2 | 8 | 3.6 | O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccccc1 | 10.1021/jm3009103 | ||
| 10391487 | 16433 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | ||
| CHEMBL112832 | 16433 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | ||
| CHEMBL319660 | 217999 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | ||||
| 44284115 | 106971 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 518 | 9 | 3 | 7 | 4.8 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL288247 | 106971 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 518 | 9 | 3 | 7 | 4.8 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 10391487 | 16433 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL112832 | 16433 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 506 | 12 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 44266903 | 21358 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 536 | 11 | 1 | 9 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10862 | 21358 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 536 | 11 | 1 | 9 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL1204672 | 21358 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 536 | 11 | 1 | 9 | 4.4 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| 44387124 | 137669 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 524 | 13 | 1 | 6 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](CC(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm031041j | ||
| CHEMBL368558 | 137669 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 524 | 13 | 1 | 6 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](CC(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm031041j | ||
| 159594 | 7310 | 45 | None | -4073 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | ||
| 3487 | 7310 | 45 | None | -4073 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | ||
| CHEMBL9194 | 7310 | 45 | None | -4073 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | ||
| DB06199 | 7310 | 45 | None | -4073 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | ||
| 9914310 | 213422 | 8 | None | - | 2 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL8923 | 213422 | 8 | None | - | 2 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 21041273 | 180527 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 538 | 12 | 2 | 9 | 2.8 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4536769 | 180527 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 538 | 12 | 2 | 9 | 2.8 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 10575845 | 18001 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 457 | 7 | 2 | 8 | 3.8 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 | 10.1021/jm9608366 | ||
| CHEMBL1178807 | 18001 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 457 | 7 | 2 | 8 | 3.8 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 | 10.1021/jm9608366 | ||
| CHEMBL43788 | 18001 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 457 | 7 | 2 | 8 | 3.8 | COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 | 10.1021/jm9608366 | ||
| CHEMBL97470 | 222704 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 11732669 | 209896 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 426 | 9 | 1 | 6 | 5.0 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCC)cc21 | 10.1021/jm010382z | ||
| CHEMBL64039 | 209896 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 426 | 9 | 1 | 6 | 5.0 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCC)cc21 | 10.1021/jm010382z | ||
| 44298343 | 108570 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 485 | 9 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC#N)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL300066 | 108570 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 485 | 9 | 1 | 7 | 5.8 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC#N)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 159594 | 7310 | 45 | None | - | 3 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm960077r | ||
| 3487 | 7310 | 45 | None | - | 3 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm960077r | ||
| CHEMBL9194 | 7310 | 45 | None | - | 3 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm960077r | ||
| DB06199 | 7310 | 45 | None | - | 3 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm960077r | ||
| 44371420 | 57684 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3OC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL157763 | 57684 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3OC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| 9888574 | 110953 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 4 | 1 | 4 | 3.9 | CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL309692 | 110953 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 4 | 1 | 4 | 3.9 | CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 10429404 | 111655 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 372 | 5 | 1 | 4 | 3.7 | CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL311138 | 111655 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 372 | 5 | 1 | 4 | 3.7 | CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/0960-894X(96)00441-6 | ||
| 10670372 | 104022 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)cc(OC)c3)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL268754 | 104022 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)cc(OC)c3)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| 44327423 | 214320 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 483 | 6 | 1 | 8 | 2.8 | Cc1cc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)nc1C | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL94720 | 214320 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 483 | 6 | 1 | 8 | 2.8 | Cc1cc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)nc1C | 10.1016/S0960-894X(96)00617-8 | ||
| 10915215 | 107580 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 354 | 4 | 1 | 5 | 3.8 | CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@@H](c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL293161 | 107580 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 354 | 4 | 1 | 5 | 3.8 | CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@@H](c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 44305079 | 108868 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 354 | 4 | 1 | 5 | 3.8 | CC(C)Oc1ccc2c(c1)C=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL302189 | 108868 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 354 | 4 | 1 | 5 | 3.8 | CC(C)Oc1ccc2c(c1)C=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 21041249 | 88437 | 1 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 648 | 11 | 1 | 8 | 4.7 | CN(Cc1ccccc1)S(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2163688 | 88437 | 1 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 648 | 11 | 1 | 8 | 4.7 | CN(Cc1ccccc1)S(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| 44384656 | 136873 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 468 | 5 | 1 | 7 | 4.5 | Cc1noc(NS(=O)(=O)c2ccsc2/C=C/c2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL367763 | 136873 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 468 | 5 | 1 | 7 | 4.5 | Cc1noc(NS(=O)(=O)c2ccsc2/C=C/c2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| 21979601 | 88775 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 602 | 13 | 2 | 10 | 3.7 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL2165328 | 88775 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 602 | 13 | 2 | 10 | 3.7 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 | 10.1016/j.bmcl.2016.06.014 | ||
| 21979601 | 88775 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 602 | 13 | 2 | 10 | 3.7 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2165328 | 88775 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 602 | 13 | 2 | 10 | 3.7 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 10647372 | 213896 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 454 | 8 | 1 | 6 | 3.1 | CCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9212 | 213896 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 454 | 8 | 1 | 6 | 3.1 | CCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL2304016 | 216251 | 0 | None | - | 0 | Pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC(C)[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Cl)[nH]c3ccccc23)NC1=O | 10.1021/jm9600914 | ||||
| 44333889 | 11855 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 463 | 7 | 1 | 6 | 5.3 | CCCSc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL105494 | 11855 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 463 | 7 | 1 | 6 | 5.3 | CCCSc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| 44334084 | 116430 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 461 | 7 | 2 | 6 | 3.8 | COc1ccc([C@@H]2c3nc(CCC(=O)O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL322434 | 116430 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 461 | 7 | 2 | 6 | 3.8 | COc1ccc([C@@H]2c3nc(CCC(=O)O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| 18617333 | 112304 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 424 | 4 | 1 | 5 | 3.3 | COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL312187 | 112304 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 424 | 4 | 1 | 5 | 3.3 | COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 44309488 | 210788 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 471 | 7 | 1 | 8 | 5.1 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nonc2c1 | 10.1016/s0960-894x(97)10151-2 | ||
| CHEMBL69664 | 210788 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 471 | 7 | 1 | 8 | 5.1 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nonc2c1 | 10.1016/s0960-894x(97)10151-2 | ||
| 10814655 | 214379 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9502 | 214379 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44385127 | 68142 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 482 | 5 | 1 | 7 | 4.8 | Cc1cc2c(cc1/C=C/c1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL176854 | 68142 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 482 | 5 | 1 | 7 | 4.8 | Cc1cc2c(cc1/C=C/c1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL409339 | 219540 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(96)00127-8 | ||||
| 44284115 | 106971 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 518 | 9 | 3 | 7 | 4.8 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL288247 | 106971 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 518 | 9 | 3 | 7 | 4.8 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 11826173 | 209599 | 1 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 4.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL62363 | 209599 | 1 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 4.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC)cc32)cc1 | 10.1021/jm010382z | ||
| 44298956 | 202459 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 489 | 9 | 1 | 7 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1OC)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | ||
| CHEMBL55666 | 202459 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 489 | 9 | 1 | 7 | 4.8 | CCOc1ccc2c(c1)c(-c1ccc(OC)cc1OC)c(C(=O)O)c(=O)n2Cc1ccccc1OC | 10.1016/S0960-894X(97)00319-3 | ||
| 44270602 | 105634 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 688 | 13 | 1 | 10 | 7.0 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1cccs1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL278930 | 105634 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 688 | 13 | 1 | 10 | 7.0 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1cccs1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| 10553165 | 16512 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 492 | 7 | 1 | 6 | 5.4 | O=C1OC(O)(c2ccc(OCc3ccccc3)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm9606507 | ||
| CHEMBL11341 | 16512 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 492 | 7 | 1 | 6 | 5.4 | O=C1OC(O)(c2ccc(OCc3ccccc3)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 | 10.1021/jm9606507 | ||
| 44276946 | 113623 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc(Cl)c4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144735 | 113623 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 4.2 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc(Cl)c4c(c3)OCO4)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 10650062 | 67218 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 537 | 10 | 4 | 6 | 4.8 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| CHEMBL175228 | 67218 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 537 | 10 | 4 | 6 | 4.8 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| 18184206 | 67106 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 600 | 13 | 2 | 11 | 3.2 | CCS(=O)(=O)NCCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL174413 | 67106 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 600 | 13 | 2 | 11 | 3.2 | CCS(=O)(=O)NCCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 155564169 | 182112 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 545 | 11 | 1 | 12 | 2.0 | COc1ccc(Cl)c(Oc2c(NS(C)(=O)=O)ncnc2OCCOc2ncc(S(C)(=O)=O)cn2)c1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4574034 | 182112 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 545 | 11 | 1 | 12 | 2.0 | COc1ccc(Cl)c(Oc2c(NS(C)(=O)=O)ncnc2OCCOc2ncc(S(C)(=O)=O)cn2)c1 | 10.1016/j.bmcl.2016.06.014 | ||
| 42630655 | 25179 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 557 | 11 | 2 | 7 | 5.5 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL1271586 | 25179 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 557 | 11 | 2 | 7 | 5.5 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 42630655 | 25179 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 557 | 11 | 2 | 7 | 5.5 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| CHEMBL1271586 | 25179 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 557 | 11 | 2 | 7 | 5.5 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| 17869231 | 21398 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 548 | 11 | 1 | 9 | 5.5 | COc1cc(C/C(C(=O)c2ccc(OC(C)C)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1205061 | 21398 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 548 | 11 | 1 | 9 | 5.5 | COc1cc(C/C(C(=O)c2ccc(OC(C)C)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL48315 | 21398 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 548 | 11 | 1 | 9 | 5.5 | COc1cc(C/C(C(=O)c2ccc(OC(C)C)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC | 10.1016/s0960-894x(98)00301-1 | ||
| 44327412 | 214360 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 497 | 5 | 1 | 8 | 3.0 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL94929 | 214360 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 497 | 5 | 1 | 8 | 3.0 | Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| 44367767 | 50522 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 469 | 9 | 2 | 6 | 4.5 | COc1ccc(CN(Cc2cc3c(cc2Cl)OCO3)C(Cc2ccc(O)cc2)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL151064 | 50522 | 0 | None | - | 0 | Pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 469 | 9 | 2 | 6 | 4.5 | COc1ccc(CN(Cc2cc3c(cc2Cl)OCO3)C(Cc2ccc(O)cc2)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| 10814746 | 188373 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 484 | 6 | 1 | 8 | 3.8 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| CHEMBL47706 | 188373 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 484 | 6 | 1 | 8 | 3.8 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| 44368481 | 128298 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 435 | 9 | 2 | 7 | 2.8 | CCOC(=O)CN(Cc1cc2c(cc1Cl)OCO2)C(Cc1ccc(O)cc1)C(=O)O | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL358444 | 128298 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 435 | 9 | 2 | 7 | 2.8 | CCOC(=O)CN(Cc1cc2c(cc1Cl)OCO2)C(Cc1ccc(O)cc1)C(=O)O | 10.1016/s0960-894x(01)00009-9 | ||
| 9840391 | 111316 | 6 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 328 | 4 | 1 | 4 | 3.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL310427 | 111316 | 6 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 328 | 4 | 1 | 4 | 3.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 10721386 | 67149 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 550 | 11 | 5 | 5 | 4.8 | CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)[nH]2)c2ccccc21 | 10.1021/jm950592+ | ||
| CHEMBL174686 | 67149 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 550 | 11 | 5 | 5 | 4.8 | CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)[nH]2)c2ccccc21 | 10.1021/jm950592+ | ||
| 44386535 | 138143 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 549 | 10 | 4 | 6 | 4.9 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccc(F)c2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL368853 | 138143 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 549 | 10 | 4 | 6 | 4.9 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccc(F)c2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL414165 | 219894 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](c2cccs2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | ||||
| 71451528 | 88464 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 631 | 14 | 1 | 12 | 4.3 | CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL2163715 | 88464 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 631 | 14 | 1 | 12 | 4.3 | CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1016/j.bmcl.2016.06.014 | ||
| 71451528 | 88464 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 631 | 14 | 1 | 12 | 4.3 | CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| CHEMBL2163715 | 88464 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 631 | 14 | 1 | 12 | 4.3 | CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| 71462248 | 88478 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 676 | 17 | 2 | 12 | 3.8 | COCCOc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 | 10.1021/jm3009103 | ||
| CHEMBL2163728 | 88478 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 676 | 17 | 2 | 12 | 3.8 | COCCOc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 | 10.1021/jm3009103 | ||
| 21041307 | 181748 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 482 | 10 | 2 | 9 | 2.6 | CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4566095 | 181748 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 482 | 10 | 2 | 9 | 2.6 | CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL265116 | 217414 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | ||||
| 44298324 | 202648 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 448 | 7 | 2 | 7 | 4.4 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CO)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL55876 | 202648 | 0 | None | - | 0 | Pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 448 | 7 | 2 | 7 | 4.4 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CO)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 9869444 | 104021 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL268751 | 104021 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 | 10.1016/0960-894X(96)00170-9 | ||
| 10769045 | 137995 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 551 | 10 | 4 | 6 | 5.0 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2(C)CCCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL368641 | 137995 | 0 | None | - | 0 | Pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 551 | 10 | 4 | 6 | 5.0 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2(C)CCCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| 71455065 | 88474 | 1 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 679 | 14 | 2 | 11 | 4.8 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ccncc2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| CHEMBL2163724 | 88474 | 1 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 679 | 14 | 2 | 11 | 4.8 | COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ccncc2)nc1OCCOc1ncc(Br)cn1 | 10.1021/jm3009103 | ||
| 137655285 | 165756 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 568 | 10 | 3 | 10 | 3.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCCN)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4096211 | 165756 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 568 | 10 | 3 | 10 | 3.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCCN)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 23445219 | 119252 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 428 | 5 | 1 | 6 | 4.3 | COc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL329861 | 119252 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 428 | 5 | 1 | 6 | 4.3 | COc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1016/S0960-894X(96)00496-9 | ||
| 10129267 | 88463 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 617 | 13 | 1 | 12 | 3.9 | CCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| CHEMBL2163714 | 88463 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 617 | 13 | 1 | 12 | 3.9 | CCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| 44384723 | 137665 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 563 | 13 | 2 | 10 | 3.0 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL368528 | 137665 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 563 | 13 | 2 | 10 | 3.0 | CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 58688008 | 182081 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 496 | 11 | 2 | 9 | 3.0 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4573273 | 182081 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 496 | 11 | 2 | 9 | 3.0 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 155563100 | 182055 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 619 | 13 | 2 | 10 | 4.6 | COc1cnc(OCCOc2nc(-c3ccncc3)nc(NS(=O)(=O)NCc3ccccc3)c2-c2ccc(Cl)cc2)nc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4572734 | 182055 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 619 | 13 | 2 | 10 | 4.6 | COc1cnc(OCCOc2nc(-c3ccncc3)nc(NS(=O)(=O)NCc3ccccc3)c2-c2ccc(Cl)cc2)nc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 9829478 | 182104 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 567 | 10 | 1 | 8 | 4.9 | Cc1ccc(-c2c(NS(=O)(=O)/C=C/c3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4573806 | 182104 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 567 | 10 | 1 | 8 | 4.9 | Cc1ccc(-c2c(NS(=O)(=O)/C=C/c3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 10281929 | 16165 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 588 | 16 | 1 | 7 | 5.3 | CCCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| CHEMBL111517 | 16165 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 588 | 16 | 1 | 7 | 5.3 | CCCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| 10816152 | 23105 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 534 | 9 | 2 | 8 | 3.9 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(OC)cccc2OC)cc1 | 10.1021/jm990170q | ||
| CHEMBL122832 | 23105 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 534 | 9 | 2 | 8 | 3.9 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(OC)cccc2OC)cc1 | 10.1021/jm990170q | ||
| 9826741 | 107534 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 486 | 5 | 1 | 9 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL292802 | 107534 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 486 | 5 | 1 | 9 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00132-7 | ||
| 44327734 | 214879 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 561 | 8 | 1 | 9 | 3.9 | COc1ccc(-c2ccc(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL97851 | 214879 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 561 | 8 | 1 | 9 | 3.9 | COc1ccc(-c2ccc(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| 10265127 | 103611 | 2 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 270 | 3 | 1 | 4 | 2.2 | Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL26522 | 103611 | 2 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 270 | 3 | 1 | 4 | 2.2 | Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 10076527 | 21387 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 485 | 7 | 2 | 6 | 4.3 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3ccccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| CHEMBL1204990 | 21387 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 485 | 7 | 2 | 6 | 4.3 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3ccccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| 22467237 | 92118 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 549 | 8 | 3 | 8 | 2.3 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(CC(=O)O)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261357 | 92118 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 549 | 8 | 3 | 8 | 2.3 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(CC(=O)O)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1007/s00044-004-0021-y | ||
| 9826741 | 107534 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 486 | 5 | 1 | 9 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00367-3 | ||
| CHEMBL292802 | 107534 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 486 | 5 | 1 | 9 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00367-3 | ||
| 10599230 | 213774 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 2.8 | CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9141 | 213774 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 2.8 | CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 11113541 | 210047 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 476 | 7 | 1 | 7 | 5.2 | COc1ccc(OC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL64632 | 210047 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 476 | 7 | 1 | 7 | 5.2 | COc1ccc(OC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| 11015023 | 109497 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 406 | 3 | 1 | 4 | 5.1 | O=C(O)C1=C(c2ccc(Cl)cc2)c2ccccc2OC1c1ccc2c(c1)OCO2 | 10.1021/jm010382z | ||
| CHEMBL304875 | 109497 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 406 | 3 | 1 | 4 | 5.1 | O=C(O)C1=C(c2ccc(Cl)cc2)c2ccccc2OC1c1ccc2c(c1)OCO2 | 10.1021/jm010382z | ||
| 11826259 | 209684 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 437 | 8 | 1 | 7 | 4.5 | CC(C)Oc1ccc2c(c1)C(OCCCC#N)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL62759 | 209684 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 437 | 8 | 1 | 7 | 4.5 | CC(C)Oc1ccc2c(c1)C(OCCCC#N)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 44316527 | 212259 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 280 | 3 | 1 | 4 | 2.7 | Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2C)c1 | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80532 | 212259 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 280 | 3 | 1 | 4 | 2.7 | Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2C)c1 | 10.1016/0960-894X(96)00441-6 | ||
| 10211772 | 63297 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 660 | 11 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL163638 | 63297 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 660 | 11 | 2 | 12 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | ||
| 10815167 | 107970 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 497 | 7 | 2 | 6 | 5.4 | CCC(C)c1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | ||
| CHEMBL295697 | 107970 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 497 | 7 | 2 | 6 | 5.4 | CCC(C)c1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | ||
| CHEMBL2304015 | 216250 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O | 10.1021/jm9600914 | ||||
| CHEMBL405599 | 219347 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 44328019 | 162483 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 1000 | 26 | 9 | 8 | 5.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL405178 | 162483 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 1000 | 26 | 9 | 8 | 5.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 44327347 | 103538 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 1102 | 26 | 9 | 8 | 7.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1c2ccccc2CCc2ccccc21)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL264579 | 103538 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 1102 | 26 | 9 | 8 | 7.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1c2ccccc2CCc2ccccc21)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 10961510 | 209614 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 458 | 7 | 1 | 4 | 6.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL62425 | 209614 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 458 | 7 | 1 | 4 | 6.6 | COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| 10696788 | 182694 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 501 | 5 | 2 | 9 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Oc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| CHEMBL45872 | 182694 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 501 | 5 | 2 | 9 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Oc2ccc3c(c2)OCO3)c1Br | 10.1021/jm9700068 | ||
| 44316526 | 212200 | 2 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 344 | 3 | 1 | 4 | 3.2 | Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80180 | 212200 | 2 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 344 | 3 | 1 | 4 | 3.2 | Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 23445506 | 119335 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 428 | 5 | 1 | 6 | 4.3 | COc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL330003 | 119335 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 428 | 5 | 1 | 6 | 4.3 | COc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| 23445227 | 127603 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 472 | 6 | 1 | 8 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2COc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL355800 | 127603 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 472 | 6 | 1 | 8 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2COc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00132-7 | ||
| 10719598 | 213769 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9139 | 213769 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44284437 | 106760 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 520 | 9 | 4 | 8 | 3.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL286621 | 106760 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 520 | 9 | 4 | 8 | 3.5 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 10722389 | 18897 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 606 | 10 | 2 | 6 | 6.0 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| CHEMBL1184099 | 18897 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 606 | 10 | 2 | 6 | 6.0 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| CHEMBL332424 | 18897 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 606 | 10 | 2 | 6 | 6.0 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1C | 10.1021/jm990171i | ||
| 44314661 | 109802 | 0 | None | - | 0 | Pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 603 | 14 | 5 | 4 | 5.1 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL306977 | 109802 | 0 | None | - | 0 | Pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 603 | 14 | 5 | 4 | 5.1 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 44314645 | 179451 | 0 | None | - | 0 | Pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 601 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC1CC1)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL449962 | 179451 | 0 | None | - | 0 | Pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 601 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC1CC1)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| 10507211 | 117148 | 0 | None | - | 0 | Pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 566 | 13 | 1 | 7 | 3.9 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCCCl | 10.1021/jm970101g | ||
| CHEMBL324214 | 117148 | 0 | None | - | 0 | Pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 566 | 13 | 1 | 7 | 3.9 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCCCl | 10.1021/jm970101g | ||
| CHEMBL438745 | 220572 | 0 | None | - | 0 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(96)00127-8 | ||||
| 44320783 | 113470 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 6 | 1 | 6 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccnc2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL314357 | 113470 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 6 | 1 | 6 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccnc2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| 1009 | 6982 | 25 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.1021/jm990170q | ||
| 5310991 | 6982 | 25 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.1021/jm990170q | ||
| CHEMBL332794 | 6982 | 25 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10.1021/jm990170q | ||
| 10841576 | 18215 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 620 | 11 | 2 | 6 | 6.3 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1CC | 10.1021/jm990171i | ||
| CHEMBL1180336 | 18215 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 620 | 11 | 2 | 6 | 6.3 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1CC | 10.1021/jm990171i | ||
| CHEMBL122673 | 18215 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 620 | 11 | 2 | 6 | 6.3 | CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1CC | 10.1021/jm990171i | ||
| 10650477 | 121026 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 10 | 2 | 6 | 5.8 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC(C)C)cc1 | 10.1021/jm990170q | ||
| CHEMBL333009 | 121026 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 10 | 2 | 6 | 5.8 | CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC(C)C)cc1 | 10.1021/jm990170q | ||
| 10209319 | 16142 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 546 | 13 | 1 | 7 | 4.1 | CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC | 10.1021/jm970101g | ||
| CHEMBL111355 | 16142 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 546 | 13 | 1 | 7 | 4.1 | CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC | 10.1021/jm970101g | ||
| CHEMBL412460 | 219770 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)80156-6 | ||||
| CHEMBL328942 | 218095 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| CHEMBL433349 | 220416 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 9896251 | 105549 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm020138n | ||
| CHEMBL278176 | 105549 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm020138n | ||
| 44213959 | 177147 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 592 | 11 | 3 | 9 | 5.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(=O)Nc2ccccc2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4447655 | 177147 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 592 | 11 | 3 | 9 | 5.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(=O)Nc2ccccc2)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL313984 | 217902 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| CHEMBL1791271 | 215695 | 2 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00152-J | ||||
| 9896251 | 105549 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL278176 | 105549 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| 44404967 | 142196 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | ||
| CHEMBL372814 | 142196 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | ||
| 44311528 | 210921 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 633 | 12 | 2 | 10 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70487 | 210921 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 633 | 12 | 2 | 10 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 | 10.1016/S0960-894X(97)00400-9 | ||
| 10650546 | 18892 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 562 | 7 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2c3ccccc3-c3ccccc32)cc1 | 10.1021/jm990171i | ||
| CHEMBL1184091 | 18892 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 562 | 7 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2c3ccccc3-c3ccccc32)cc1 | 10.1021/jm990171i | ||
| CHEMBL332144 | 18892 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 562 | 7 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2c3ccccc3-c3ccccc32)cc1 | 10.1021/jm990171i | ||
| 44327656 | 148567 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 977 | 25 | 9 | 8 | 4.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL386181 | 148567 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 977 | 25 | 9 | 8 | 4.7 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 10918533 | 109620 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 536 | 8 | 1 | 6 | 6.8 | CC(C)Oc1ccc2c(c1)C(c1ccc(OCc3ccccc3)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL305577 | 109620 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 536 | 8 | 1 | 6 | 6.8 | CC(C)Oc1ccc2c(c1)C(c1ccc(OCc3ccccc3)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 10674095 | 120290 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 544 | 9 | 1 | 6 | 5.1 | CCc1cccc(CC)c1N(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| CHEMBL332093 | 120290 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 544 | 9 | 1 | 6 | 5.1 | CCc1cccc(CC)c1N(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| 8260 | 7319 | 54 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 9912992 | 7319 | 54 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL3989834 | 7319 | 54 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 479 | 8 | 1 | 9 | 3.9 | COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 10578853 | 110369 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 564 | 10 | 1 | 11 | 3.4 | COC(=O)COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | ||
| CHEMBL308646 | 110369 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 564 | 10 | 1 | 11 | 3.4 | COC(=O)COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | ||
| CHEMBL1793926 | 215709 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm970161m | ||||
| CHEMBL318020 | 217988 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | ||||
| 10504689 | 16213 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 474 | 6 | 1 | 8 | 3.6 | COC(=O)c1cccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)c1 | 10.1021/jm9606507 | ||
| CHEMBL11176 | 16213 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 474 | 6 | 1 | 8 | 3.6 | COC(=O)c1cccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)c1 | 10.1021/jm9606507 | ||
| 10895198 | 107731 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 426 | 9 | 1 | 6 | 5.0 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cccc(OCCC)c21 | 10.1021/jm010382z | ||
| CHEMBL294123 | 107731 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 426 | 9 | 1 | 6 | 5.0 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cccc(OCCC)c21 | 10.1021/jm010382z | ||
| 10814318 | 15924 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 472 | 14 | 1 | 5 | 4.7 | C=CCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| CHEMBL110064 | 15924 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 472 | 14 | 1 | 5 | 4.7 | C=CCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| 44439102 | 97074 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 508 | 8 | 1 | 7 | 5.2 | CN(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1ccno1)C(=O)CC(C)(C)C | 10.1016/j.bmcl.2006.10.009 | ||
| CHEMBL238539 | 97074 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 508 | 8 | 1 | 7 | 5.2 | CN(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1ccno1)C(=O)CC(C)(C)C | 10.1016/j.bmcl.2006.10.009 | ||
| 10305181 | 67223 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 666 | 11 | 2 | 12 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)NC1CCCCC1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL175278 | 67223 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 666 | 11 | 2 | 12 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)NC1CCCCC1 | 10.1016/s0960-894x(02)01084-3 | ||
| 23445498 | 213479 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 426 | 4 | 1 | 5 | 4.9 | Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL89688 | 213479 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 426 | 4 | 1 | 5 | 4.9 | Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(96)00496-9 | ||
| 44284041 | 107079 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 9 | 3 | 8 | 4.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL289216 | 107079 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 9 | 3 | 8 | 4.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 11801523 | 15028 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 588 | 16 | 1 | 7 | 5.3 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCC)cc1 | 10.1021/jm970101g | ||
| CHEMBL109242 | 15028 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 588 | 16 | 1 | 7 | 5.3 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCC)cc1 | 10.1021/jm970101g | ||
| 15453170 | 111678 | 4 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 328 | 4 | 1 | 4 | 3.8 | Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL311258 | 111678 | 4 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 328 | 4 | 1 | 4 | 3.8 | Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 10916597 | 210094 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL64832 | 210094 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 410 | 7 | 1 | 5 | 5.4 | CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL2370254 | 216597 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 44291583 | 108167 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 500 | 8 | 3 | 9 | 2.9 | COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 | 10.1021/jm9608366 | ||
| CHEMBL297215 | 108167 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 500 | 8 | 3 | 9 | 2.9 | COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 | 10.1021/jm9608366 | ||
| CHEMBL336033 | 218353 | 1 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm00021a021 | ||||
| 23445285 | 119154 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 454 | 7 | 1 | 5 | 5.6 | CCCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL329560 | 119154 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 454 | 7 | 1 | 5 | 5.6 | CCCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | ||
| 58688006 | 177895 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 524 | 13 | 2 | 9 | 3.8 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4458005 | 177895 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 524 | 13 | 2 | 9 | 3.8 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 10165809 | 138577 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 541 | 9 | 2 | 11 | 2.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL369362 | 138577 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 541 | 9 | 2 | 11 | 2.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| 137637038 | 162720 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 581 | 11 | 2 | 9 | 5.0 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4061110 | 162720 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 581 | 11 | 2 | 9 | 5.0 | CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 10577255 | 182198 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 497 | 8 | 2 | 6 | 5.2 | CCCCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | ||
| CHEMBL45760 | 182198 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 497 | 8 | 2 | 6 | 5.2 | CCCCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | ||
| 10576378 | 107900 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 471 | 6 | 2 | 7 | 3.9 | COc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br | 10.1021/jm9608366 | ||
| CHEMBL295207 | 107900 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 471 | 6 | 2 | 7 | 3.9 | COc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br | 10.1021/jm9608366 | ||
| 10623888 | 169937 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 461 | 8 | 1 | 6 | 3.4 | CCCCS(=O)(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL417971 | 169937 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 461 | 8 | 1 | 6 | 3.4 | CCCCS(=O)(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 10230835 | 117010 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 546 | 12 | 1 | 7 | 4.0 | CCCS(=O)(=O)N(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)CC(C)C | 10.1021/jm970101g | ||
| CHEMBL323789 | 117010 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 546 | 12 | 1 | 7 | 4.0 | CCCS(=O)(=O)N(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)CC(C)C | 10.1021/jm970101g | ||
| 10344914 | 106913 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 476 | 7 | 3 | 7 | 4.1 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL287711 | 106913 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 476 | 7 | 3 | 7 | 4.1 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 9936145 | 25799 | 2 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 510 | 11 | 1 | 4 | 5.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 | 10.1021/jm010237l | ||
| CHEMBL128818 | 25799 | 2 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 510 | 11 | 1 | 4 | 5.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 | 10.1021/jm010237l | ||
| 10577829 | 16439 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 518 | 13 | 1 | 7 | 3.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCCO1 | 10.1021/jm980217s | ||
| CHEMBL112877 | 16439 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 518 | 13 | 1 | 7 | 3.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCCO1 | 10.1021/jm980217s | ||
| 10278777 | 174911 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| CHEMBL432974 | 174911 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 502 | 14 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| 44322947 | 213480 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 428 | 5 | 1 | 6 | 4.3 | COc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL89689 | 213480 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 428 | 5 | 1 | 6 | 4.3 | COc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | ||
| 11798998 | 213614 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9050 | 213614 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 482 | 10 | 1 | 6 | 3.9 | CCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 21041284 | 177716 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 568 | 13 | 2 | 9 | 3.9 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4455360 | 177716 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 568 | 13 | 2 | 9 | 3.9 | CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 44334065 | 174601 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 429 | 5 | 1 | 5 | 4.7 | COc1ccc([C@@H]2c3nc(C4CC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL430695 | 174601 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 429 | 5 | 1 | 5 | 4.7 | COc1ccc([C@@H]2c3nc(C4CC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| 44334146 | 174779 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 446 | 7 | 2 | 6 | 4.6 | CCCNc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL432012 | 174779 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 446 | 7 | 2 | 6 | 4.6 | CCCNc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| 44311285 | 109076 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 635 | 13 | 2 | 10 | 6.4 | CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL303428 | 109076 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 635 | 13 | 2 | 10 | 6.4 | CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 | 10.1016/S0960-894X(97)00400-9 | ||
| 159594 | 7310 | 45 | None | -4073 | 3 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990171i | ||
| 3487 | 7310 | 45 | None | -4073 | 3 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990171i | ||
| CHEMBL9194 | 7310 | 45 | None | -4073 | 3 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990171i | ||
| DB06199 | 7310 | 45 | None | -4073 | 3 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm990171i | ||
| 44327881 | 168454 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 1044 | 26 | 9 | 8 | 6.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| CHEMBL413179 | 168454 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 1044 | 26 | 9 | 8 | 6.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||
| 10597575 | 13668 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 408 | 5 | 1 | 6 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCC2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10843 | 13668 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 408 | 5 | 1 | 6 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCC2)cc1 | 10.1021/jm9606507 | ||
| 10576377 | 18779 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 471 | 6 | 2 | 7 | 3.9 | COc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1021/jm9608366 | ||
| CHEMBL1183291 | 18779 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 471 | 6 | 2 | 7 | 3.9 | COc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1021/jm9608366 | ||
| CHEMBL288967 | 18779 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 471 | 6 | 2 | 7 | 3.9 | COc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1021/jm9608366 | ||
| 10503525 | 12639 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10794 | 12639 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 446 | 6 | 1 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1 | 10.1021/jm9606507 | ||
| 44368414 | 128065 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 459 | 9 | 1 | 5 | 4.2 | COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccccc2)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL357978 | 128065 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 459 | 9 | 1 | 5 | 4.2 | COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccccc2)C(=O)O)cc1 | 10.1016/s0960-894x(01)00009-9 | ||
| 44371396 | 56292 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 5.9 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3SC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL156532 | 56292 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 5.9 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3SC)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| 10992620 | 210129 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 384 | 5 | 1 | 6 | 3.8 | COC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL65070 | 210129 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 384 | 5 | 1 | 6 | 3.8 | COC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 10766067 | 16510 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 8 | 1 | 5 | 3.3 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL113379 | 16510 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 8 | 1 | 5 | 3.3 | CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 44213924 | 214275 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 567 | 7 | 1 | 7 | 4.8 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3ccc(Cl)cc3)CCC2=O)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL94426 | 214275 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 567 | 7 | 1 | 7 | 4.8 | CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3ccc(Cl)cc3)CCC2=O)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| 10289311 | 117212 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 514 | 13 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C=C(C)C | 10.1021/jm980217s | ||
| CHEMBL324586 | 117212 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 514 | 13 | 1 | 5 | 5.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C=C(C)C | 10.1021/jm980217s | ||
| 23445388 | 213303 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 398 | 4 | 1 | 5 | 4.3 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL88506 | 213303 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 398 | 4 | 1 | 5 | 4.3 | Cc1noc(NS(=O)(=O)c2sccc2-c2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| 44333598 | 115967 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 6 | 4.6 | CCCOc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL321520 | 115967 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 6 | 4.6 | CCCOc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| 22009947 | 92119 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 3.6 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261358 | 92119 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 3.6 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL413825 | 219866 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(95)00084-7 | ||||
| 10602726 | 172565 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 549 | 10 | 4 | 5 | 5.1 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)o1 | 10.1021/jm950591h | ||
| CHEMBL424764 | 172565 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 549 | 10 | 4 | 5 | 5.1 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)o1 | 10.1021/jm950591h | ||
| 10506524 | 67954 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 536 | 9 | 4 | 5 | 4.2 | CNC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C | 10.1021/jm950592+ | ||
| CHEMBL176565 | 67954 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 536 | 9 | 4 | 5 | 4.2 | CNC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C | 10.1021/jm950592+ | ||
| 9806559 | 15922 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 515 | 13 | 1 | 6 | 3.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O | 10.1021/jm980217s | ||
| CHEMBL110053 | 15922 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 515 | 13 | 1 | 6 | 3.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O | 10.1021/jm980217s | ||
| 71456864 | 88467 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 618 | 13 | 2 | 12 | 3.0 | CCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| CHEMBL2163718 | 88467 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 618 | 13 | 2 | 12 | 3.0 | CCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC | 10.1021/jm3009103 | ||
| 10233400 | 135463 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL366885 | 135463 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 | 10.1016/s0960-894x(02)01084-3 | ||
| 10651146 | 115641 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 596 | 12 | 1 | 8 | 4.4 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| CHEMBL321035 | 115641 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 596 | 12 | 1 | 8 | 4.4 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| 10415067 | 52139 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 546 | 8 | 2 | 6 | 5.0 | O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL152713 | 52139 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 546 | 8 | 2 | 6 | 5.0 | O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00009-9 | ||
| 44371531 | 171644 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 467 | 6 | 1 | 5 | 6.3 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C(C)C)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL422002 | 171644 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 467 | 6 | 1 | 5 | 6.3 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C(C)C)c3c2oc2ccccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| 10433234 | 212226 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 436 | 5 | 1 | 4 | 4.3 | CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80342 | 212226 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 436 | 5 | 1 | 4 | 4.3 | CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL2369714 | 216435 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00152-J | ||||
| 44368482 | 51458 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 523 | 8 | 2 | 7 | 4.2 | O=C(O)C(Cc1ccc(O)cc1)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL152091 | 51458 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 523 | 8 | 2 | 7 | 4.2 | O=C(O)C(Cc1ccc(O)cc1)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00009-9 | ||
| 44386143 | 137470 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 571 | 9 | 3 | 6 | 5.2 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCc3ccccc32)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL368360 | 137470 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 571 | 9 | 3 | 6 | 5.2 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCc3ccccc32)nc1C(=O)O | 10.1021/jm950592+ | ||
| 44385490 | 138586 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 532 | 10 | 4 | 7 | 4.2 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccn2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL369386 | 138586 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 532 | 10 | 4 | 7 | 4.2 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccn2)nc1C(=O)O | 10.1021/jm950592+ | ||
| 23445544 | 68149 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 438 | 5 | 1 | 5 | 5.1 | Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL176912 | 68149 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 438 | 5 | 1 | 5 | 5.1 | Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00133-9 | ||
| 44266640 | 104893 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 459 | 4 | 1 | 8 | 4.2 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL273529 | 104893 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 459 | 4 | 1 | 8 | 4.2 | O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 | 10.1016/0960-894X(96)00170-9 | ||
| 44368416 | 51466 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 540 | 8 | 2 | 6 | 5.6 | O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)Cc1cc2c(cc1Cl)OCO2 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL152098 | 51466 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 540 | 8 | 2 | 6 | 5.6 | O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)Cc1cc2c(cc1Cl)OCO2 | 10.1016/s0960-894x(01)00009-9 | ||
| 18996000 | 106128 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 491 | 9 | 1 | 7 | 6.1 | CCCOc1ccc2c(Sc3cccc(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL282398 | 106128 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 491 | 9 | 1 | 7 | 6.1 | CCCOc1ccc2c(Sc3cccc(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 | 10.1016/0960-894X(96)00232-6 | ||
| 18617354 | 212256 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 384 | 3 | 1 | 4 | 3.9 | Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80507 | 212256 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 384 | 3 | 1 | 4 | 3.9 | Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 10648135 | 16114 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 472 | 13 | 1 | 5 | 4.7 | C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| CHEMBL111218 | 16114 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 472 | 13 | 1 | 5 | 4.7 | C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| 44386621 | 68051 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 549 | 10 | 4 | 6 | 4.5 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL176653 | 68051 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 549 | 10 | 4 | 6 | 4.5 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O | 10.1021/jm950592+ | ||
| 10768346 | 138321 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 522 | 10 | 5 | 5 | 4.0 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL369202 | 138321 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 522 | 10 | 5 | 5 | 4.0 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| 10527774 | 190467 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 455 | 5 | 2 | 6 | 4.2 | Cc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1021/jm9608366 | ||
| CHEMBL48031 | 190467 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 455 | 5 | 2 | 6 | 4.2 | Cc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1021/jm9608366 | ||
| 10718688 | 190405 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 457 | 5 | 3 | 7 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(O)c2)c1Br | 10.1021/jm9608366 | ||
| CHEMBL48024 | 190405 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 457 | 5 | 3 | 7 | 3.6 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(O)c2)c1Br | 10.1021/jm9608366 | ||
| 10548486 | 180895 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 391 | 5 | 2 | 6 | 3.7 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm9608366 | ||
| CHEMBL45456 | 180895 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 391 | 5 | 2 | 6 | 3.7 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm9608366 | ||
| 42630531 | 25260 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 543 | 9 | 2 | 7 | 5.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)C)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| CHEMBL1272299 | 25260 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 543 | 9 | 2 | 7 | 5.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)C)ccc31)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| 10650638 | 15956 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 566 | 13 | 1 | 6 | 4.8 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 | 10.1021/jm970101g | ||
| CHEMBL110305 | 15956 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 566 | 13 | 1 | 6 | 4.8 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 | 10.1021/jm970101g | ||
| 18738878 | 201611 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 8 | 2 | 7 | 4.2 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL539420 | 201611 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 8 | 2 | 7 | 4.2 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| 44266851 | 21357 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 550 | 11 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1C | 10.1021/jm9606507 | ||
| CHEMBL10847 | 21357 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 550 | 11 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1C | 10.1021/jm9606507 | ||
| CHEMBL1204671 | 21357 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 550 | 11 | 1 | 9 | 4.7 | COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1C | 10.1021/jm9606507 | ||
| 44371450 | 55638 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(OC)c(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL155937 | 55638 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 485 | 7 | 1 | 7 | 5.2 | COc1ccc(OC)c(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL2370253 | 216596 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 10151203 | 107577 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 429 | 5 | 1 | 6 | 4.2 | COc1ccc(Cn2c(=O)c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3ccccc32)cc1 | 10.1016/S0960-894X(97)00319-3 | ||
| CHEMBL293151 | 107577 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 429 | 5 | 1 | 6 | 4.2 | COc1ccc(Cn2c(=O)c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3ccccc32)cc1 | 10.1016/S0960-894X(97)00319-3 | ||
| 76312118 | 92122 | 0 | None | -691 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 522 | 7 | 2 | 8 | 3.4 | COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261361 | 92122 | 0 | None | -691 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 522 | 7 | 2 | 8 | 3.4 | COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 | 10.1007/s00044-004-0021-y | ||
| 23445412 | 109039 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 426 | 5 | 1 | 7 | 4.3 | Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1016/S0960-894X(97)00367-3 | ||
| CHEMBL303203 | 109039 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 426 | 5 | 1 | 7 | 4.3 | Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1016/S0960-894X(97)00367-3 | ||
| 21041297 | 176386 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 12 | 2 | 9 | 3.4 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4436531 | 176386 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 12 | 2 | 9 | 3.4 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 1011 | 10125 | 29 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 609 | 12 | 3 | 10 | 4.8 | OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O | 10.1016/j.bmcl.2016.06.014 | ||
| 5312146 | 10125 | 29 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 609 | 12 | 3 | 10 | 4.8 | OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL1628620 | 10125 | 29 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 609 | 12 | 3 | 10 | 4.8 | OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O | 10.1016/j.bmcl.2016.06.014 | ||
| 11015645 | 209966 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 438 | 9 | 1 | 5 | 6.1 | CCCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL64282 | 209966 | 0 | None | - | 0 | Pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 438 | 9 | 1 | 5 | 6.1 | CCCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 18738879 | 97008 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 548 | 8 | 2 | 7 | 4.8 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 | 10.1007/s00044-004-0021-y | ||
| CHEMBL23833 | 97008 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 548 | 8 | 2 | 7 | 4.8 | CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 | 10.1007/s00044-004-0021-y | ||
| 18995996 | 105978 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 569 | 10 | 1 | 8 | 6.9 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OCc4ccccc4)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL281451 | 105978 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 569 | 10 | 1 | 8 | 6.9 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OCc4ccccc4)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| 10971076 | 209642 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 386 | 3 | 1 | 4 | 4.7 | Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL62585 | 209642 | 0 | None | - | 0 | Pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 386 | 3 | 1 | 4 | 4.7 | Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 | 10.1021/jm010382z | ||
| 10627378 | 67197 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 598 | 11 | 5 | 4 | 5.6 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)[nH]1 | 10.1021/jm950591h | ||
| CHEMBL175103 | 67197 | 0 | None | - | 0 | Pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 598 | 11 | 5 | 4 | 5.6 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)[nH]1 | 10.1021/jm950591h | ||
| 10815168 | 174930 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 497 | 5 | 2 | 6 | 5.2 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)(C)C)cc2)c1Br | 10.1021/jm9608366 | ||
| CHEMBL433074 | 174930 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 497 | 5 | 2 | 6 | 5.2 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)(C)C)cc2)c1Br | 10.1021/jm9608366 | ||
| 137647152 | 164429 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 581 | 10 | 2 | 9 | 4.8 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4081426 | 164429 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 581 | 10 | 2 | 9 | 4.8 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 10745942 | 16083 | 0 | None | - | 0 | Pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 588 | 13 | 1 | 8 | 4.3 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc2c(c1)OCCO2 | 10.1021/jm970101g | ||
| CHEMBL111010 | 16083 | 0 | None | - | 0 | Pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 588 | 13 | 1 | 8 | 4.3 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc2c(c1)OCCO2 | 10.1021/jm970101g | ||
| 11050177 | 17031 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 585 | 10 | 1 | 9 | 6.1 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccco3)cn2)cc1 | 10.1021/jm0102304 | ||
| CHEMBL116108 | 17031 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 585 | 10 | 1 | 9 | 6.1 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccco3)cn2)cc1 | 10.1021/jm0102304 | ||
| CHEMBL175501 | 17031 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 585 | 10 | 1 | 9 | 6.1 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccco3)cn2)cc1 | 10.1021/jm0102304 | ||
| 9853680 | 105424 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 771 | 17 | 2 | 14 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL277275 | 105424 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 771 | 17 | 2 | 14 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 44314580 | 211916 | 0 | None | - | 0 | Pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 13 | 5 | 5 | 4.5 | CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C(C)C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL78023 | 211916 | 0 | None | - | 0 | Pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 13 | 5 | 5 | 4.5 | CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C(C)C)C(=O)O | 10.1021/jm9600914 | ||
| 10697520 | 18889 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 530 | 10 | 2 | 6 | 4.9 | CCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| CHEMBL1184086 | 18889 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 530 | 10 | 2 | 6 | 4.9 | CCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| CHEMBL331936 | 18889 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 530 | 10 | 2 | 6 | 4.9 | CCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 | 10.1021/jm990171i | ||
| CHEMBL384792 | 219114 | 0 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)NC(=O)[C@H]2CCCN2C1=O | 10.1016/0960-894X(96)00127-8 | ||||
| 44314658 | 211947 | 0 | None | - | 0 | Pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 589 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL78230 | 211947 | 0 | None | - | 0 | Pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 589 | 13 | 5 | 4 | 4.7 | CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL1788127 | 217895 | 8 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| CHEMBL313760 | 217895 | 8 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| 19432649 | 211267 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 487 | 9 | 2 | 8 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCO | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL72473 | 211267 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 487 | 9 | 2 | 8 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCO | 10.1016/S0960-894X(97)00400-9 | ||
| 44311321 | 210964 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 607 | 11 | 2 | 10 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1cccnc1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70788 | 210964 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 607 | 11 | 2 | 10 | 5.7 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1cccnc1 | 10.1016/S0960-894X(97)00400-9 | ||
| 18617284 | 211987 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 350 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL78552 | 211987 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 350 | 3 | 1 | 4 | 3.2 | Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 44339714 | 118085 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 500 | 14 | 1 | 5 | 5.4 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC/C=C(/C)CC | 10.1021/jm980217s | ||
| CHEMBL326685 | 118085 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 500 | 14 | 1 | 5 | 5.4 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC/C=C(/C)CC | 10.1021/jm980217s | ||
| 10138169 | 106137 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | ||
| CHEMBL282470 | 106137 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl | 10.1021/jm9700068 | ||
| CHEMBL85341 | 222667 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00095a029 | ||||
| 44266567 | 105009 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 461 | 5 | 1 | 8 | 4.5 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(-c3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL274368 | 105009 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 461 | 5 | 1 | 8 | 4.5 | COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(-c3ccc4c(c3)OCO4)c2cc1OC | 10.1016/0960-894X(96)00170-9 | ||
| 44383536 | 127175 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 362 | 3 | 2 | 5 | 2.9 | C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 | 10.1016/s0960-894x(00)00136-0 | ||
| CHEMBL353502 | 127175 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 362 | 3 | 2 | 5 | 2.9 | C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 | 10.1016/s0960-894x(00)00136-0 | ||
| 11133491 | 108946 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 416 | 3 | 1 | 6 | 4.2 | O=C(O)C1=C(c2ccc3c(c2)OCO3)c2ccccc2OC1c1ccc2c(c1)OCO2 | 10.1021/jm010382z | ||
| CHEMBL302659 | 108946 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 416 | 3 | 1 | 6 | 4.2 | O=C(O)C1=C(c2ccc3c(c2)OCO3)c2ccccc2OC1c1ccc2c(c1)OCO2 | 10.1021/jm010382z | ||
| 11122785 | 209754 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 426 | 8 | 1 | 6 | 4.6 | COCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL63057 | 209754 | 0 | None | - | 0 | Pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 426 | 8 | 1 | 6 | 4.6 | COCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 10184817 | 16346 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 488 | 14 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)CCC | 10.1021/jm980217s | ||
| CHEMBL112417 | 16346 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 488 | 14 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)CCC | 10.1021/jm980217s | ||
| 21041370 | 88777 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 636 | 13 | 2 | 10 | 4.4 | COc1ccc(Cl)c(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1021/jm3009103 | ||
| CHEMBL2165330 | 88777 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 636 | 13 | 2 | 10 | 4.4 | COc1ccc(Cl)c(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 | 10.1021/jm3009103 | ||
| 52949155 | 25183 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 557 | 10 | 2 | 7 | 5.4 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL1271640 | 25183 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 557 | 10 | 2 | 7 | 5.4 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 11070564 | 210179 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 460 | 7 | 1 | 6 | 5.2 | CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 | 10.1021/jm010382z | ||
| CHEMBL65494 | 210179 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 460 | 7 | 1 | 6 | 5.2 | CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 | 10.1021/jm010382z | ||
| 11058202 | 209602 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 388 | 4 | 1 | 5 | 4.4 | CC(C)Oc1ccc2c(c1)C(Cl)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL62374 | 209602 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 388 | 4 | 1 | 5 | 4.4 | CC(C)Oc1ccc2c(c1)C(Cl)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 10696818 | 16422 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 502 | 15 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(CC)CC | 10.1021/jm980217s | ||
| CHEMBL112770 | 16422 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 502 | 15 | 1 | 5 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(CC)CC | 10.1021/jm980217s | ||
| 10814222 | 16324 | 0 | None | - | 0 | Pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 470 | 10 | 1 | 6 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL112325 | 16324 | 0 | None | - | 0 | Pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 470 | 10 | 1 | 6 | 3.4 | CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 44291775 | 107944 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 6 | 1 | 10 | 4.1 | CC#N.Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2cc3c(cc2C#N)OCO3)c1Cl | 10.1021/jm9700068 | ||
| CHEMBL295557 | 107944 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 6 | 1 | 10 | 4.1 | CC#N.Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2cc3c(cc2C#N)OCO3)c1Cl | 10.1021/jm9700068 | ||
| 23445538 | 66845 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 456 | 6 | 1 | 6 | 4.8 | Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL173805 | 66845 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 456 | 6 | 1 | 6 | 4.8 | Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 | 10.1016/S0960-894X(97)00132-7 | ||
| 9808602 | 115986 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 590 | 15 | 1 | 8 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 | 10.1021/jm970101g | ||
| CHEMBL321673 | 115986 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 590 | 15 | 1 | 8 | 4.5 | CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 | 10.1021/jm970101g | ||
| CHEMBL330144 | 218106 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C | 10.1021/jm00015a003 | ||||
| CHEMBL97431 | 222703 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | ||||
| 10993320 | 209759 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 412 | 6 | 1 | 6 | 4.6 | CC(C)OC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL63067 | 209759 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 412 | 6 | 1 | 6 | 4.6 | CC(C)OC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 44383592 | 66676 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 386 | 4 | 1 | 5 | 3.6 | C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(=O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 | 10.1016/s0960-894x(00)00136-0 | ||
| CHEMBL173059 | 66676 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 386 | 4 | 1 | 5 | 3.6 | C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(=O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 | 10.1016/s0960-894x(00)00136-0 | ||
| 10625269 | 21228 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)cc2C)cc1 | 10.1021/jm990170q | ||
| CHEMBL120106 | 21228 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)cc2C)cc1 | 10.1021/jm990170q | ||
| CHEMBL411797 | 219736 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 15289331 | 106340 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 433 | 6 | 1 | 6 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3ccccc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL283648 | 106340 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 433 | 6 | 1 | 6 | 5.3 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3ccccc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| 18617381 | 112458 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 300 | 3 | 1 | 4 | 3.1 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL312551 | 112458 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 300 | 3 | 1 | 4 | 3.1 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 10504542 | 186342 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 469 | 6 | 2 | 6 | 4.4 | CCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | ||
| CHEMBL47418 | 186342 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 469 | 6 | 2 | 6 | 4.4 | CCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | ||
| 22998396 | 107591 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 398 | 4 | 1 | 5 | 4.3 | Cc1noc(NS(=O)(=O)c2ccsc2-c2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL293232 | 107591 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 398 | 4 | 1 | 5 | 4.3 | Cc1noc(NS(=O)(=O)c2ccsc2-c2ccccc2)c1Br | 10.1016/S0960-894X(96)00496-9 | ||
| 10604167 | 19189 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 640 | 10 | 2 | 6 | 6.4 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL1185826 | 19189 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 640 | 10 | 2 | 6 | 6.4 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL434986 | 19189 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 640 | 10 | 2 | 6 | 6.4 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| 10185233 | 66836 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 497 | 8 | 2 | 8 | 3.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL173721 | 66836 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 497 | 8 | 2 | 8 | 3.8 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| 44385576 | 138155 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 539 | 10 | 1 | 10 | 3.4 | C#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL368929 | 138155 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 539 | 10 | 1 | 10 | 3.4 | C#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 11113473 | 210148 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 472 | 6 | 1 | 5 | 6.3 | CC(C)Oc1ccc2c(c1)C(c1ccc(C(C)C)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL65201 | 210148 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 472 | 6 | 1 | 5 | 6.3 | CC(C)Oc1ccc2c(c1)C(c1ccc(C(C)C)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 11798762 | 213402 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 9 | 1 | 7 | 3.1 | CCCS(=O)(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL8911 | 213402 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 9 | 1 | 7 | 3.1 | CCCS(=O)(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL405709 | 219355 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | ||||
| 10792782 | 138142 | 0 | None | - | 0 | Pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 551 | 10 | 4 | 6 | 5.0 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL368847 | 138142 | 0 | None | - | 0 | Pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 551 | 10 | 4 | 6 | 5.0 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| 137638953 | 163626 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 579 | 10 | 2 | 9 | 4.6 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4071505 | 163626 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 579 | 10 | 2 | 9 | 4.6 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 11798109 | 19131 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 457 | 7 | 2 | 7 | 4.2 | COc1cccc(NCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1021/jm9608366 | ||
| CHEMBL1185459 | 19131 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 457 | 7 | 2 | 7 | 4.2 | COc1cccc(NCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1021/jm9608366 | ||
| CHEMBL416086 | 19131 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 457 | 7 | 2 | 7 | 4.2 | COc1cccc(NCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 | 10.1021/jm9608366 | ||
| 44314610 | 109633 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 671 | 12 | 6 | 5 | 3.9 | CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]cn1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL305650 | 109633 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 671 | 12 | 6 | 5 | 3.9 | CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]cn1)C(=O)O | 10.1021/jm9600914 | ||
| 71451525 | 88446 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 629 | 12 | 1 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 | 10.1021/jm3009103 | ||
| CHEMBL2163697 | 88446 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 629 | 12 | 1 | 12 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 | 10.1021/jm3009103 | ||
| 18995999 | 105288 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 477 | 6 | 1 | 8 | 5.0 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL27617 | 105288 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 477 | 6 | 1 | 8 | 5.0 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 | 10.1016/0960-894X(96)00232-6 | ||
| 10719367 | 105006 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)cc(OC)c2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL274359 | 105006 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)cc(OC)c2)cc1 | 10.1021/jm9606507 | ||
| 11826847 | 209698 | 1 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccccc1OC)O2 | 10.1021/jm010382z | ||
| CHEMBL62814 | 209698 | 1 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 474 | 8 | 1 | 6 | 5.6 | CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccccc1OC)O2 | 10.1021/jm010382z | ||
| CHEMBL405677 | 219353 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | CC(=O)[C@@H](Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00084-7 | ||||
| 11103224 | 209432 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 510 | 14 | 1 | 6 | 7.3 | CCCCCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL61406 | 209432 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 510 | 14 | 1 | 6 | 7.3 | CCCCCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 44384177 | 127071 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 6 | 1 | 8 | 4.6 | Cc1noc(NS(=O)(=O)c2ccsc2COc2cc3c(cc2Cl)OCO3)c1Br | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL352657 | 127071 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 6 | 1 | 8 | 4.6 | Cc1noc(NS(=O)(=O)c2ccsc2COc2cc3c(cc2Cl)OCO3)c1Br | 10.1016/S0960-894X(97)00132-7 | ||
| 10721344 | 14312 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 548 | 13 | 1 | 8 | 3.0 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCOC | 10.1021/jm970101g | ||
| CHEMBL108748 | 14312 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 548 | 13 | 1 | 8 | 3.0 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCOC | 10.1021/jm970101g | ||
| 10144334 | 137442 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 561 | 10 | 2 | 10 | 4.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL368211 | 137442 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 561 | 10 | 2 | 10 | 4.0 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| 11113542 | 209989 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 476 | 8 | 1 | 6 | 5.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3OC)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL64398 | 209989 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 476 | 8 | 1 | 6 | 5.5 | COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3OC)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| 44311288 | 210963 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 592 | 11 | 1 | 10 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1cccnc1 | 10.1016/S0960-894X(97)00400-9 | ||
| CHEMBL70781 | 210963 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 592 | 11 | 1 | 10 | 5.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1cccnc1 | 10.1016/S0960-894X(97)00400-9 | ||
| 10918390 | 26093 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 522 | 12 | 1 | 5 | 5.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 | 10.1021/jm010237l | ||
| CHEMBL129060 | 26093 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 522 | 12 | 1 | 5 | 5.3 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 | 10.1021/jm010237l | ||
| 44327714 | 214718 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.2 | COc1ccc(-c2cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL96935 | 214718 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.2 | COc1ccc(-c2cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 | 10.1016/S0960-894X(96)00617-8 | ||
| 10743478 | 116045 | 0 | None | - | 0 | Pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 484 | 12 | 1 | 4 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL321852 | 116045 | 0 | None | - | 0 | Pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 484 | 12 | 1 | 4 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 10029171 | 105541 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 505 | 6 | 2 | 7 | 3.0 | Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL278109 | 105541 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 505 | 6 | 2 | 7 | 3.0 | Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| 10503334 | 180123 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br | 10.1016/S0960-894X(97)00367-3 | ||
| CHEMBL45269 | 180123 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br | 10.1016/S0960-894X(97)00367-3 | ||
| 10503334 | 180123 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br | 10.1021/jm9608366 | ||
| CHEMBL45269 | 180123 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br | 10.1021/jm9608366 | ||
| 11080933 | 210191 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 454 | 10 | 1 | 6 | 5.7 | CCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL65599 | 210191 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 454 | 10 | 1 | 6 | 5.7 | CCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 44284041 | 107079 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 520 | 9 | 3 | 8 | 4.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL289216 | 107079 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 520 | 9 | 3 | 8 | 4.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 9870830 | 213493 | 38 | None | -66 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL8981 | 213493 | 38 | None | -66 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | ||
| 11122784 | 169701 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 426 | 8 | 1 | 6 | 4.9 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| CHEMBL417413 | 169701 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 426 | 8 | 1 | 6 | 4.9 | CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 | 10.1021/jm010382z | ||
| 9870830 | 213493 | 38 | None | - | 2 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/j.bmc.2009.08.058 | ||
| CHEMBL8981 | 213493 | 38 | None | - | 2 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1016/j.bmc.2009.08.058 | ||
| CHEMBL2369713 | 216434 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(95)00152-J | ||||
| 9870830 | 213493 | 38 | None | -66 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm980504w | ||
| CHEMBL8981 | 213493 | 38 | None | -66 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm980504w | ||
| 21041324 | 88439 | 5 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 542 | 11 | 2 | 8 | 3.5 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2163690 | 88439 | 5 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 542 | 11 | 2 | 8 | 3.5 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 | 10.1021/jm3009103 | ||
| 10918216 | 209621 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 508 | 7 | 1 | 6 | 6.0 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OCc4ccccc4)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL62450 | 209621 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 508 | 7 | 1 | 6 | 6.0 | COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OCc4ccccc4)cc32)cc1 | 10.1021/jm010382z | ||
| 15453177 | 212300 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL80857 | 212300 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 392 | 4 | 1 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 14041110 | 106790 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 322 | 2 | 2 | 3 | 2.5 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccccc21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL286808 | 106790 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 322 | 2 | 2 | 3 | 2.5 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccccc21 | 10.1016/0960-894X(95)00230-Q | ||
| 10626245 | 137940 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 539 | 10 | 2 | 8 | 5.5 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)OC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| CHEMBL368629 | 137940 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 539 | 10 | 2 | 8 | 5.5 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)OC2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| 10647172 | 213545 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.6 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2Cc2ccc(F)cc2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9012 | 213545 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.6 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2Cc2ccc(F)cc2)cc1 | 10.1021/jm9505369 | ||
| 9803428 | 108981 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 442 | 5 | 1 | 9 | 3.4 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Cl | 10.1016/S0960-894X(97)00367-3 | ||
| CHEMBL302872 | 108981 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 442 | 5 | 1 | 9 | 3.4 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Cl | 10.1016/S0960-894X(97)00367-3 | ||
| 10793053 | 18230 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 564 | 9 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL1180363 | 18230 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 564 | 9 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| CHEMBL123994 | 18230 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 564 | 9 | 2 | 6 | 5.2 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm990171i | ||
| 9852318 | 16386 | 8 | None | -2691 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| CHEMBL112624 | 16386 | 8 | None | -2691 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| CHEMBL1627022 | 16386 | 8 | None | -2691 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| 44334150 | 11306 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.0 | COc1ccc([C@@H]2c3nc(CC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL102314 | 11306 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.0 | COc1ccc([C@@H]2c3nc(CC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1016/s0960-894x(02)00663-7 | ||
| 44371773 | 55367 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 562 | 8 | 1 | 8 | 4.6 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc(N(C)S(C)(=O)=O)ccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| CHEMBL155708 | 55367 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 562 | 8 | 1 | 8 | 4.6 | COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc(N(C)S(C)(=O)=O)ccc23)cc1 | 10.1016/s0960-894x(99)00040-2 | ||
| 44320590 | 113338 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 556 | 10 | 2 | 9 | 4.8 | COc1ccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL314206 | 113338 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 556 | 10 | 2 | 9 | 4.8 | COc1ccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL384728 | 219113 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 11733450 | 210199 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 474 | 6 | 1 | 7 | 5.0 | CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL65658 | 210199 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 474 | 6 | 1 | 7 | 5.0 | CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL2369736 | 216443 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N(C)[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm970161m | ||||
| 44270524 | 104983 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 682 | 13 | 1 | 9 | 6.9 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccccc1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL274243 | 104983 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 682 | 13 | 1 | 9 | 6.9 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccccc1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| 44368428 | 51350 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 521 | 9 | 2 | 5 | 5.5 | O=C(O)C(Cc1ccc(O)cc1)N(Cc1ccccc1-c1ccccc1)C(=O)/C=C/c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00009-9 | ||
| CHEMBL152001 | 51350 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 521 | 9 | 2 | 5 | 5.5 | O=C(O)C(Cc1ccc(O)cc1)N(Cc1ccccc1-c1ccccc1)C(=O)/C=C/c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00009-9 | ||
| 10505771 | 170135 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | ||
| CHEMBL419211 | 170135 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | ||
| 10299975 | 117031 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 488 | 14 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(C)CC | 10.1021/jm980217s | ||
| CHEMBL323791 | 117031 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 488 | 14 | 1 | 5 | 5.1 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(C)CC | 10.1021/jm980217s | ||
| 10505771 | 170135 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL419211 | 170135 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 56678451 | 70100 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 937 | 25 | 8 | 8 | 4.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(c1ccccc1)c1ccccc1)N(C)C(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm970161m | ||
| CHEMBL1793927 | 70100 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 937 | 25 | 8 | 8 | 4.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(c1ccccc1)c1ccccc1)N(C)C(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm970161m | ||
| 3795752 | 111979 | 1 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 320 | 3 | 1 | 4 | 3.4 | Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL311455 | 111979 | 1 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 320 | 3 | 1 | 4 | 3.4 | Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 10769025 | 67044 | 0 | None | - | 0 | Pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 550 | 10 | 5 | 5 | 4.6 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL174171 | 67044 | 0 | None | - | 0 | Pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 550 | 10 | 5 | 5 | 4.6 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| 137649592 | 164189 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 567 | 10 | 2 | 9 | 4.6 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4078537 | 164189 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 567 | 10 | 2 | 9 | 4.6 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 10838921 | 213125 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 494 | 7 | 1 | 6 | 4.1 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)C2CCCCC2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL8736 | 213125 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 494 | 7 | 1 | 6 | 4.1 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)C2CCCCC2)cc1 | 10.1021/jm9505369 | ||
| 10744040 | 120346 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 | 10.1021/jm990170q | ||
| CHEMBL332231 | 120346 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 | 10.1021/jm990170q | ||
| 9874379 | 67220 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 653 | 14 | 2 | 10 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL175268 | 67220 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 653 | 14 | 2 | 10 | 5.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 44320419 | 113851 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 5.1 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCC(C(=O)O)CC1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL315805 | 113851 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 5.1 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCC(C(=O)O)CC1 | 10.1016/s0960-894x(00)00513-8 | ||
| 21041267 | 88784 | 13 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 558 | 9 | 2 | 8 | 2.8 | CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2165337 | 88784 | 13 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 558 | 9 | 2 | 8 | 2.8 | CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| 10983992 | 26233 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 | 10.1021/jm010237l | ||
| CHEMBL129740 | 26233 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 506 | 12 | 1 | 4 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 | 10.1021/jm010237l | ||
| 23445468 | 18004 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 459 | 5 | 3 | 9 | 2.4 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(O)nn2)c1Br | 10.1021/jm9608366 | ||
| CHEMBL1178818 | 18004 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 459 | 5 | 3 | 9 | 2.4 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(O)nn2)c1Br | 10.1021/jm9608366 | ||
| CHEMBL44615 | 18004 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 459 | 5 | 3 | 9 | 2.4 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(O)nn2)c1Br | 10.1021/jm9608366 | ||
| 10275056 | 119286 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 5.2 | CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL329890 | 119286 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 5.2 | CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | ||
| 10577388 | 22351 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)ccc2C)cc1 | 10.1021/jm990170q | ||
| CHEMBL122111 | 22351 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)ccc2C)cc1 | 10.1021/jm990170q | ||
| 10602620 | 23363 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 544 | 10 | 2 | 6 | 5.4 | CCCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| CHEMBL123997 | 23363 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 544 | 10 | 2 | 6 | 5.4 | CCCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm990170q | ||
| 21041278 | 178556 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 3.5 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4467748 | 178556 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 3.5 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 17869279 | 21651 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 460 | 8 | 1 | 7 | 4.7 | COc1ccc(C(=O)/C(Cc2ccccc2OC)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL1207701 | 21651 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 460 | 8 | 1 | 7 | 4.7 | COc1ccc(C(=O)/C(Cc2ccccc2OC)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| CHEMBL431160 | 21651 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 460 | 8 | 1 | 7 | 4.7 | COc1ccc(C(=O)/C(Cc2ccccc2OC)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 | 10.1016/s0960-894x(98)00301-1 | ||
| 10576428 | 21359 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 473 | 8 | 2 | 6 | 4.3 | COc1ccc(C(=O)/C(Cc2ccc(NC(C)=O)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10905 | 21359 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 473 | 8 | 2 | 6 | 4.3 | COc1ccc(C(=O)/C(Cc2ccc(NC(C)=O)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| CHEMBL1204673 | 21359 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 473 | 8 | 2 | 6 | 4.3 | COc1ccc(C(=O)/C(Cc2ccc(NC(C)=O)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 | 10.1021/jm9606507 | ||
| 44385586 | 68436 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 531 | 10 | 1 | 9 | 4.7 | C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL177143 | 68436 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 531 | 10 | 1 | 9 | 4.7 | C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 10137382 | 188963 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 427 | 5 | 3 | 7 | 3.8 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(O)c1 | 10.1021/jm9608366 | ||
| CHEMBL47827 | 188963 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 427 | 5 | 3 | 7 | 3.8 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(O)c1 | 10.1021/jm9608366 | ||
| 44385792 | 67125 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 617 | 13 | 2 | 11 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL174547 | 67125 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 617 | 13 | 2 | 11 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)01083-1 | ||
| 10097589 | 213060 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 502 | 7 | 2 | 7 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCC(C(=O)O)CC1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL86965 | 213060 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 502 | 7 | 2 | 7 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCC(C(=O)O)CC1 | 10.1016/s0960-894x(00)00513-8 | ||
| 10717923 | 105469 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 439 | 5 | 2 | 6 | 4.7 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL277595 | 105469 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 439 | 5 | 2 | 6 | 4.7 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 | 10.1016/S0960-894X(97)00132-7 | ||
| 11799625 | 120575 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)c(C)c2)cc1 | 10.1021/jm990170q | ||
| CHEMBL332431 | 120575 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 502 | 7 | 2 | 6 | 4.5 | COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)c(C)c2)cc1 | 10.1021/jm990170q | ||
| 71462322 | 88785 | 11 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 572 | 10 | 2 | 8 | 3.2 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| CHEMBL2165338 | 88785 | 11 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 572 | 10 | 2 | 8 | 3.2 | CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 | 10.1021/jm3009103 | ||
| CHEMBL1791280 | 215699 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00152-J | ||||
| 44387111 | 172961 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 548 | 10 | 5 | 5 | 4.2 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL426413 | 172961 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 548 | 10 | 5 | 5 | 4.2 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O | 10.1021/jm950592+ | ||
| 10281606 | 136450 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 575 | 9 | 2 | 10 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL367382 | 136450 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 575 | 9 | 2 | 10 | 4.2 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO | 10.1016/s0960-894x(02)01084-3 | ||
| 10765750 | 169938 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 3.0 | CC[S+]([O-])CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL417972 | 169938 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 3.0 | CC[S+]([O-])CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44265906 | 104044 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 3.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOCC(C)C)cc1 | 10.1021/jm9505369 | ||
| CHEMBL268902 | 104044 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 3.9 | COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOCC(C)C)cc1 | 10.1021/jm9505369 | ||
| 18184229 | 66382 | 0 | None | - | 2 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL171950 | 66382 | 0 | None | - | 2 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 605 | 15 | 2 | 10 | 4.2 | CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL313056 | 217890 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00070a001 | ||||
| 44276947 | 113628 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 5.2 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)c(Cl)c3)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144803 | 113628 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 5.2 | COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)c(Cl)c3)c2=O)c1 | 10.1016/s0960-894x(00)00232-8 | ||
| 44327238 | 114184 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 497 | 8 | 1 | 8 | 3.1 | CCCc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL318017 | 114184 | 0 | None | - | 0 | Pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 497 | 8 | 1 | 8 | 3.1 | CCCc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 | 10.1016/S0960-894X(96)00617-8 | ||
| 44458597 | 105567 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 535 | 7 | 3 | 8 | 2.3 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2C(=O)O)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL278349 | 105567 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 535 | 7 | 3 | 8 | 2.3 | Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2C(=O)O)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 | 10.1016/s0960-894x(01)00660-6 | ||
| 10817057 | 16466 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 580 | 11 | 1 | 7 | 4.7 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1021/jm970101g | ||
| CHEMBL113087 | 16466 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 580 | 11 | 1 | 7 | 4.7 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1021/jm970101g | ||
| 10994374 | 210195 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 474 | 7 | 1 | 6 | 5.4 | COc1ccc(CC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| CHEMBL65619 | 210195 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 474 | 7 | 1 | 6 | 5.4 | COc1ccc(CC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 | 10.1021/jm010382z | ||
| 44298356 | 201764 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 503 | 10 | 2 | 8 | 5.7 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC/C=N/O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| CHEMBL54703 | 201764 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 503 | 10 | 2 | 8 | 5.7 | COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC/C=N/O)c1 | 10.1016/s0960-894x(00)00366-8 | ||
| 10791823 | 16221 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)C(=O)CCC | 10.1021/jm970101g | ||
| CHEMBL111783 | 16221 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)C(=O)CCC | 10.1021/jm970101g | ||
| 10601668 | 105222 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)cc2OC)cc1 | 10.1021/jm9606507 | ||
| CHEMBL275701 | 105222 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)cc2OC)cc1 | 10.1021/jm9606507 | ||
| 44266594 | 10973 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 491 | 8 | 1 | 8 | 4.8 | COc1ccc(-c2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)cc1OC | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL10019 | 10973 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 491 | 8 | 1 | 8 | 4.8 | COc1ccc(-c2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)cc1OC | 10.1016/0960-894X(96)00170-9 | ||
| 44266552 | 11285 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| CHEMBL10218 | 11285 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 5.3 | CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 | 10.1016/0960-894X(96)00170-9 | ||
| 9846065 | 177698 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 439 | 7 | 2 | 6 | 3.6 | O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4455096 | 177698 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 439 | 7 | 2 | 6 | 3.6 | O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 10602267 | 15359 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 529 | 13 | 1 | 6 | 3.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCCC1=O | 10.1021/jm980217s | ||
| CHEMBL109478 | 15359 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 529 | 13 | 1 | 6 | 3.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCCC1=O | 10.1021/jm980217s | ||
| 52949197 | 25196 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 555 | 10 | 2 | 7 | 5.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL1271746 | 25196 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 555 | 10 | 2 | 7 | 5.1 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL2304012 | 216247 | 0 | None | - | 0 | Pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC(C)[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC1=O | 10.1021/jm9600914 | ||||
| 44333578 | 11377 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 417 | 5 | 1 | 5 | 4.4 | CCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL102773 | 11377 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 417 | 5 | 1 | 5 | 4.4 | CCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| 44278003 | 106044 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 449 | 8 | 1 | 6 | 5.6 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL28188 | 106044 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 449 | 8 | 1 | 6 | 5.6 | COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3cc(OC)c(OC)cc23)c1 | 10.1016/0960-894X(96)00232-6 | ||
| CHEMBL2304005 | 216240 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O | 10.1021/jm9600914 | ||||
| 10625738 | 176272 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 517 | 6 | 2 | 6 | 5.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(-c3ccccc3)cc2)c1Br | 10.1021/jm9608366 | ||
| CHEMBL44321 | 176272 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 517 | 6 | 2 | 6 | 5.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(-c3ccccc3)cc2)c1Br | 10.1021/jm9608366 | ||
| 44385522 | 66400 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 642 | 13 | 2 | 11 | 4.2 | CCS(=O)(=O)NCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL172029 | 66400 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 642 | 13 | 2 | 11 | 4.2 | CCS(=O)(=O)NCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 44284329 | 107188 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 5.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL290181 | 107188 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 5.4 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 159594 | 7310 | 45 | None | -4073 | 3 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | ||
| 3487 | 7310 | 45 | None | -4073 | 3 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | ||
| CHEMBL9194 | 7310 | 45 | None | -4073 | 3 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | ||
| DB06199 | 7310 | 45 | None | -4073 | 3 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 10.1021/jm010237l | ||
| 10576427 | 12142 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 473 | 6 | 2 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(NC(C)=O)cc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL10697 | 12142 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 473 | 6 | 2 | 7 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(NC(C)=O)cc2)cc1 | 10.1021/jm9606507 | ||
| 11037806 | 209603 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 456 | 10 | 2 | 7 | 4.3 | CC(C)Oc1ccc2c(c1)C(OCCCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| CHEMBL62376 | 209603 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 456 | 10 | 2 | 7 | 4.3 | CC(C)Oc1ccc2c(c1)C(OCCCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 | 10.1021/jm010382z | ||
| 3370402 | 112568 | 5 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 252 | 3 | 1 | 4 | 2.1 | Cc1noc(NS(=O)(=O)c2ccccc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL312670 | 112568 | 5 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 252 | 3 | 1 | 4 | 2.1 | Cc1noc(NS(=O)(=O)c2ccccc2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 10670664 | 214096 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 2.6 | C=CCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9342 | 214096 | 0 | None | - | 0 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 2.6 | C=CCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 23445304 | 138124 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 484 | 6 | 1 | 7 | 4.4 | Cc1cc2c(cc1CCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL368780 | 138124 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 484 | 6 | 1 | 7 | 4.4 | Cc1cc2c(cc1CCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 | 10.1016/S0960-894X(97)00133-9 | ||
| 44320315 | 113834 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 7 | 2 | 7 | 5.0 | O=C(O)c1cccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL315638 | 113834 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 7 | 2 | 7 | 5.0 | O=C(O)c1cccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| 44279413 | 106728 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 400 | 2 | 2 | 3 | 3.3 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| CHEMBL286395 | 106728 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 400 | 2 | 2 | 3 | 3.3 | O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 | 10.1016/0960-894X(95)00230-Q | ||
| 9831527 | 136260 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 698 | 14 | 2 | 12 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL367274 | 136260 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 698 | 14 | 2 | 12 | 4.1 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(02)01083-1 | ||
| 44334129 | 115331 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 459 | 8 | 1 | 5 | 5.5 | CCCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL320208 | 115331 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 459 | 8 | 1 | 5 | 5.5 | CCCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| 10230836 | 15681 | 0 | None | - | 0 | Pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 546 | 13 | 1 | 7 | 4.1 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| CHEMBL109765 | 15681 | 0 | None | - | 0 | Pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 546 | 13 | 1 | 7 | 4.1 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm970101g | ||
| 44284288 | 106911 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 559 | 9 | 2 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| CHEMBL287683 | 106911 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 559 | 9 | 2 | 7 | 4.9 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 | 10.1016/j.bmcl.2004.01.008 | ||
| 44320375 | 113922 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 506 | 8 | 1 | 7 | 5.3 | COc1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc(OC)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL316187 | 113922 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 506 | 8 | 1 | 7 | 5.3 | COc1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc(OC)c1 | 10.1016/s0960-894x(00)00513-8 | ||
| 44320480 | 112735 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 442 | 6 | 1 | 6 | 5.4 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccco2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL312979 | 112735 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 442 | 6 | 1 | 6 | 5.4 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccco2)nn1CC1CCCCC1 | 10.1016/s0960-894x(00)00513-8 | ||
| 17885920 | 213220 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 502 | 7 | 2 | 7 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCC(C(=O)O)C1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL88011 | 213220 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 502 | 7 | 2 | 7 | 5.2 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCC(C(=O)O)C1 | 10.1016/s0960-894x(00)00513-8 | ||
| 155542285 | 179856 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 522 | 14 | 2 | 11 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1cccc(OC)c1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4519822 | 179856 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 522 | 14 | 2 | 11 | 2.9 | CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1cccc(OC)c1 | 10.1016/j.bmcl.2016.06.014 | ||
| 44270498 | 105700 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 702 | 13 | 1 | 10 | 7.2 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL279419 | 105700 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 702 | 13 | 1 | 10 | 7.2 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 | 10.1016/0960-894X(95)00186-W | ||
| CHEMBL265116 | 217414 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00015a003 | ||||
| 10722385 | 107275 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 606 | 13 | 1 | 11 | 4.6 | COC(=O)CCCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | ||
| CHEMBL291058 | 107275 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 606 | 13 | 1 | 11 | 4.6 | COC(=O)CCCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC | 10.1021/jm980504w | ||
| 9894460 | 213488 | 9 | None | - | 3 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL313871 | 213488 | 9 | None | - | 3 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/S0960-894X(96)00617-8 | ||
| CHEMBL8978 | 213488 | 9 | None | - | 3 | Pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/S0960-894X(96)00617-8 | ||
| 10410546 | 16184 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL11162 | 16184 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 432 | 7 | 1 | 6 | 4.1 | COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 | 10.1021/jm9606507 | ||
| 44316993 | 211718 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 286 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL76360 | 211718 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 286 | 3 | 1 | 4 | 2.7 | Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1C | 10.1016/0960-894X(96)00441-6 | ||
| 10627398 | 137465 | 0 | None | - | 0 | Pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 599 | 11 | 4 | 5 | 5.8 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)o1 | 10.1021/jm950591h | ||
| CHEMBL368339 | 137465 | 0 | None | - | 0 | Pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 599 | 11 | 4 | 5 | 5.8 | CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)o1 | 10.1021/jm950591h | ||
| 9959298 | 67289 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 552 | 10 | 2 | 7 | 5.4 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)N(C)C2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| CHEMBL175698 | 67289 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 552 | 10 | 2 | 7 | 5.4 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)N(C)C2CCCCC2)nc1C(=O)O | 10.1021/jm9505932 | ||
| 10764220 | 213863 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 413 | 8 | 1 | 6 | 3.3 | CCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL9189 | 213863 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 413 | 8 | 1 | 6 | 3.3 | CCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 44384966 | 66771 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 545 | 9 | 1 | 9 | 4.8 | C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL173465 | 66771 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 545 | 9 | 1 | 9 | 4.8 | C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01084-3 | ||
| 22467234 | 92128 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 534 | 7 | 1 | 8 | 4.1 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(C)=O)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261599 | 92128 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 534 | 7 | 1 | 8 | 4.1 | COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(C)=O)ccc12 | 10.1007/s00044-004-0021-y | ||
| 11799541 | 188048 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 499 | 8 | 3 | 9 | 3.4 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCCO)OCO3)c1Cl | 10.1021/jm9608366 | ||
| CHEMBL47620 | 188048 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 499 | 8 | 3 | 9 | 3.4 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCCO)OCO3)c1Cl | 10.1021/jm9608366 | ||
| CHEMBL289687 | 217654 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| 10695071 | 107935 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 454 | 6 | 1 | 6 | 4.3 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9700068 | ||
| CHEMBL295477 | 107935 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 454 | 6 | 1 | 6 | 4.3 | Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9700068 | ||
| CHEMBL289687 | 217654 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(95)00152-J | ||||
| 10599879 | 108053 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 455 | 5 | 2 | 6 | 4.2 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | ||
| CHEMBL296326 | 108053 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 455 | 5 | 2 | 6 | 4.2 | Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1021/jm9608366 | ||
| 25211074 | 25257 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 543 | 10 | 2 | 7 | 5.1 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| CHEMBL1272244 | 25257 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 543 | 10 | 2 | 7 | 5.1 | CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 | 10.1016/j.bmcl.2010.08.074 | ||
| 9871561 | 181579 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 527 | 10 | 2 | 8 | 4.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cc2)nc(C(F)(F)F)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4562189 | 181579 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 527 | 10 | 2 | 8 | 4.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cc2)nc(C(F)(F)F)nc1OCCO | 10.1016/j.bmcl.2016.06.014 | ||
| 10168597 | 68111 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL176741 | 68111 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 661 | 11 | 2 | 13 | 3.6 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 | 10.1016/s0960-894x(02)01084-3 | ||
| 44213278 | 113626 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)cc1 | 10.1016/s0960-894x(00)00232-8 | ||
| CHEMBL3144799 | 113626 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 406 | 5 | 1 | 5 | 3.6 | COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)cc1 | 10.1016/s0960-894x(00)00232-8 | ||
| 23445404 | 107688 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 456 | 5 | 1 | 7 | 4.1 | Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00367-3 | ||
| CHEMBL293877 | 107688 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 456 | 5 | 1 | 7 | 4.1 | Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00367-3 | ||
| 10621170 | 18012 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 402 | 5 | 2 | 8 | 3.0 | Cc1cc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)no1 | 10.1021/jm9608366 | ||
| CHEMBL1178890 | 18012 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 402 | 5 | 2 | 8 | 3.0 | Cc1cc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)no1 | 10.1021/jm9608366 | ||
| CHEMBL48120 | 18012 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 402 | 5 | 2 | 8 | 3.0 | Cc1cc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)no1 | 10.1021/jm9608366 | ||
| 23445256 | 66963 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 470 | 6 | 1 | 7 | 4.1 | Cc1noc(NS(=O)(=O)c2ccsc2CCc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL173982 | 66963 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 470 | 6 | 1 | 7 | 4.1 | Cc1noc(NS(=O)(=O)c2ccsc2CCc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| 44340049 | 117108 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 500 | 13 | 1 | 5 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| CHEMBL323951 | 117108 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 500 | 13 | 1 | 5 | 5.3 | C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC | 10.1021/jm980217s | ||
| 10383884 | 211988 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 359 | 4 | 2 | 5 | 2.9 | CNc1ccc(C)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL78563 | 211988 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 359 | 4 | 2 | 5 | 2.9 | CNc1ccc(C)cc1S(=O)(=O)Nc1onc(C)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 10673644 | 16554 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 524 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL113611 | 16554 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 524 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 76324075 | 92615 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 340 | 4 | 1 | 6 | 4.0 | Cc1c(C(=O)O)oc2cccc(OCc3ccc4nsnc4c3)c12 | 10.1007/s00044-013-0542-3 | ||
| CHEMBL2296899 | 92615 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 340 | 4 | 1 | 6 | 4.0 | Cc1c(C(=O)O)oc2cccc(OCc3ccc4nsnc4c3)c12 | 10.1007/s00044-013-0542-3 | ||
| CHEMBL315658 | 217970 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/S0960-894X(01)81215-4 | ||||
| CHEMBL315658 | 217970 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| 9809270 | 138118 | 0 | None | - | 2 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 622 | 14 | 2 | 12 | 2.3 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| CHEMBL368738 | 138118 | 0 | None | - | 2 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 622 | 14 | 2 | 12 | 2.3 | CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC | 10.1016/s0960-894x(02)01083-1 | ||
| 137643691 | 165037 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 569 | 10 | 2 | 7 | 5.5 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4088634 | 165037 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 569 | 10 | 2 | 7 | 5.5 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 23445272 | 134528 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 4.7 | Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL366364 | 134528 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 4.7 | Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(97)00133-9 | ||
| 44458670 | 105828 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 521 | 7 | 2 | 8 | 2.7 | COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| CHEMBL280379 | 105828 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 521 | 7 | 2 | 8 | 2.7 | COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 | 10.1016/s0960-894x(01)00660-6 | ||
| 10238141 | 202630 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 429 | 5 | 1 | 6 | 4.2 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2ccccc21 | 10.1016/S0960-894X(97)00319-3 | ||
| CHEMBL55853 | 202630 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 429 | 5 | 1 | 6 | 4.2 | COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2ccccc21 | 10.1016/S0960-894X(97)00319-3 | ||
| 44333887 | 115402 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 446 | 7 | 2 | 6 | 3.9 | CCNCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| CHEMBL320631 | 115402 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 446 | 7 | 2 | 6 | 3.9 | CCNCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(02)00663-7 | ||
| 18617403 | 212052 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 394 | 3 | 1 | 4 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| CHEMBL79031 | 212052 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 394 | 3 | 1 | 4 | 3.3 | Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1Br | 10.1016/0960-894X(96)00441-6 | ||
| 10142669 | 16216 | 0 | None | - | 0 | Pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 518 | 11 | 1 | 7 | 3.3 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC | 10.1021/jm970101g | ||
| CHEMBL111769 | 16216 | 0 | None | - | 0 | Pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 518 | 11 | 1 | 7 | 3.3 | CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC | 10.1021/jm970101g | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.ejmech.2016.06.006 | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.ejmech.2016.06.006 | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.ejmech.2016.06.006 | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.ejmech.2016.06.006 | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.ejmech.2016.06.006 | ||
| 104865 | 7493 | 99 | None | -123 | 4 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmc.2015.01.003 | ||
| 3494 | 7493 | 99 | None | -123 | 4 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmc.2015.01.003 | ||
| 392 | 7493 | 99 | None | -123 | 4 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmc.2015.01.003 | ||
| CHEMBL957 | 7493 | 99 | None | -123 | 4 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmc.2015.01.003 | ||
| DB00559 | 7493 | 99 | None | -123 | 4 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1016/j.bmc.2015.01.003 | ||
| 10790757 | 103988 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | ||
| CHEMBL268480 | 103988 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2)cc1 | 10.1021/jm9606507 | ||
| 11027946 | 25685 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 540 | 12 | 1 | 5 | 5.4 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 | 10.1021/jm010237l | ||
| CHEMBL128479 | 25685 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 540 | 12 | 1 | 5 | 5.4 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 | 10.1021/jm010237l | ||
| 44387111 | 172961 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 548 | 10 | 5 | 5 | 4.2 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL426413 | 172961 | 0 | None | - | 0 | Pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 548 | 10 | 5 | 5 | 4.2 | Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O | 10.1021/jm950592+ | ||
| 10289348 | 16085 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 516 | 16 | 1 | 5 | 5.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(CCC)CCC | 10.1021/jm980217s | ||
| CHEMBL111023 | 16085 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 516 | 16 | 1 | 5 | 5.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(CCC)CCC | 10.1021/jm980217s | ||
| 71458717 | 88445 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 433 | 9 | 2 | 10 | 1.5 | COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCO | 10.1021/jm3009103 | ||
| CHEMBL2163696 | 88445 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 433 | 9 | 2 | 10 | 1.5 | COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCO | 10.1021/jm3009103 | ||
| 44320432 | 213034 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 442 | 6 | 1 | 7 | 3.6 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1OCCO1 | 10.1016/s0960-894x(00)00513-8 | ||
| CHEMBL86821 | 213034 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 442 | 6 | 1 | 7 | 3.6 | O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1OCCO1 | 10.1016/s0960-894x(00)00513-8 | ||
| 23445523 | 66795 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 472 | 6 | 1 | 8 | 3.9 | Cc1noc(NS(=O)(=O)c2sccc2COc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00132-7 | ||
| CHEMBL173557 | 66795 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 472 | 6 | 1 | 8 | 3.9 | Cc1noc(NS(=O)(=O)c2sccc2COc2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00132-7 | ||
| 22998508 | 213711 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 4.6 | Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | ||
| CHEMBL91073 | 213711 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 4.6 | Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 | 10.1016/S0960-894X(96)00496-9 | ||
| 10649321 | 117723 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | ||
| CHEMBL326191 | 117723 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | ||
| CHEMBL328942 | 218095 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00015a003 | ||||
| 10649321 | 117723 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| CHEMBL326191 | 117723 | 0 | None | - | 0 | Pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 508 | 12 | 1 | 5 | 4.9 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm960077r | ||
| 10602312 | 66437 | 0 | None | - | 0 | Pig | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 531 | 11 | 5 | 5 | 4.5 | Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL172178 | 66437 | 0 | None | - | 0 | Pig | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 531 | 11 | 5 | 5 | 4.5 | Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O | 10.1021/jm950592+ | ||
| 137633242 | 163259 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 569 | 10 | 2 | 10 | 3.8 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCOC)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| CHEMBL4067475 | 163259 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 569 | 10 | 2 | 10 | 3.8 | CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCOC)ccc31)OCO2 | 10.1016/j.bmcl.2017.04.049 | ||
| 10189776 | 66831 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 651 | 11 | 1 | 10 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | ||
| CHEMBL173689 | 66831 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 651 | 11 | 1 | 10 | 6.3 | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOc1ccccc1 | 10.1016/s0960-894x(02)01084-3 | ||
| 10766198 | 169664 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 455 | 6 | 2 | 6 | 3.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NCc2ccccc2)c1Br | 10.1021/jm9608366 | ||
| CHEMBL417358 | 169664 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 455 | 6 | 2 | 6 | 3.5 | Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NCc2ccccc2)c1Br | 10.1021/jm9608366 | ||
| 9914310 | 213422 | 8 | None | -1995 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL8923 | 213422 | 8 | None | -1995 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL315780 | 217971 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c1csc2ccccc12)[C@@H](C)CC | 10.1021/jm00070a001 | ||||
| 11477084 | 10382 | 53 | None | - | 2 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | ||
| 216235 | 10382 | 53 | None | - | 2 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | ||
| 3548 | 10382 | 53 | None | - | 2 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | ||
| 3950 | 10382 | 53 | None | - | 2 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | ||
| CHEMBL282724 | 10382 | 53 | None | - | 2 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | ||
| DB06268 | 10382 | 53 | None | - | 2 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | 10.1021/jm9700068 | ||
| 10673644 | 16554 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 524 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | ||
| CHEMBL113611 | 16554 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 524 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 | 10.1021/jm010237l | ||
| 16004692 | 9232 | 91 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | ||
| 4809 | 9232 | 91 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | ||
| 7352 | 9232 | 91 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL2103873 | 9232 | 91 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | ||
| DB08932 | 9232 | 91 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | 10.1016/j.bmcl.2016.06.014 | ||
| 10070 | 7237 | 47 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 10.1016/j.bmcl.2016.06.014 | ||
| 25099191 | 7237 | 47 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL2165326 | 7237 | 47 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 10.1016/j.bmcl.2016.06.014 | ||
| DB15059 | 7237 | 47 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 10.1016/j.bmcl.2016.06.014 | ||
| 10070 | 7237 | 47 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 10.1021/jm3009103 | ||
| 25099191 | 7237 | 47 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 10.1021/jm3009103 | ||
| CHEMBL2165326 | 7237 | 47 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 10.1021/jm3009103 | ||
| DB15059 | 7237 | 47 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 8 | 2 | 8 | 2.5 | Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N | 10.1021/jm3009103 | ||
| 44314906 | 110355 | 0 | None | - | 0 | Pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 607 | 12 | 6 | 5 | 3.4 | Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)NC(Cc1c[nH]cn1)C(=O)O | 10.1021/jm9600914 | ||
| CHEMBL308621 | 110355 | 0 | None | - | 0 | Pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 607 | 12 | 6 | 5 | 3.4 | Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)NC(Cc1c[nH]cn1)C(=O)O | 10.1021/jm9600914 | ||
| 10697377 | 67861 | 0 | None | - | 0 | Pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 523 | 10 | 4 | 6 | 4.2 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| CHEMBL176513 | 67861 | 0 | None | - | 0 | Pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 523 | 10 | 4 | 6 | 4.2 | Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O | 10.1021/jm950592+ | ||
| 23445458 | 67074 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 468 | 5 | 1 | 7 | 4.5 | Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| CHEMBL174363 | 67074 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 468 | 5 | 1 | 7 | 4.5 | Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2ccc3c(c2)OCO3)c1Br | 10.1016/S0960-894X(97)00133-9 | ||
| 44284481 | 220504 | 0 | None | 3 | 5 | Rat | 11.0 | pKi | = | 11 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00087a001 | ||||
| CHEMBL437472 | 220504 | 0 | None | 3 | 5 | Rat | 11.0 | pKi | = | 11 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00087a001 | ||||
| 131845706 | 10245 | 6 | None | 11 | 2 | Rat | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| 71308726 | 10245 | 6 | None | 11 | 2 | Rat | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| 995 | 10245 | 6 | None | 11 | 2 | Rat | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| CHEMBL1222310 | 10245 | 6 | None | 11 | 2 | Rat | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| CHEMBL4524099 | 10245 | 6 | None | 11 | 2 | Rat | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| 131845706 | 10245 | 6 | None | 11 | 2 | Rat | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| 71308726 | 10245 | 6 | None | 11 | 2 | Rat | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| 995 | 10245 | 6 | None | 11 | 2 | Rat | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| CHEMBL1222310 | 10245 | 6 | None | 11 | 2 | Rat | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| CHEMBL4524099 | 10245 | 6 | None | 11 | 2 | Rat | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00087a001 | ||||
| 44284481 | 220504 | 0 | None | 3 | 5 | Rat | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00087a001 | ||||
| CHEMBL437472 | 220504 | 0 | None | 3 | 5 | Rat | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00087a001 | ||||
| 155543936 | 180014 | 0 | None | 218776 | 2 | Rat | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 2514 | 48 | 34 | 38 | -9.8 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CC(N)=O)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00087a001 | ||
| CHEMBL4524100 | 180014 | 0 | None | 218776 | 2 | Rat | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 2514 | 48 | 34 | 38 | -9.8 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CC(N)=O)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00087a001 | ||
| CHEMBL1790180 | 215662 | 0 | None | -1 | 3 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.ejmech.2013.01.044 | ||||
| CHEMBL1790180 | 215662 | 0 | None | 1 | 3 | Rat | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00087a001 | ||||
| 155543936 | 180014 | 0 | None | 218776 | 2 | Rat | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 2514 | 48 | 34 | 38 | -9.8 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CC(N)=O)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00087a001 | ||
| CHEMBL4524100 | 180014 | 0 | None | 218776 | 2 | Rat | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 2514 | 48 | 34 | 38 | -9.8 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CC(N)=O)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00087a001 | ||
| CHEMBL1790180 | 215662 | 0 | None | 1 | 3 | Rat | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm00087a001 | ||||
| CHEMBL1790180 | 215662 | 0 | None | -1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1021/jm8007618 | ||||
| 44284481 | 220504 | 0 | None | -4 | 5 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.bmcl.2013.01.025 | ||||
| CHEMBL437472 | 220504 | 0 | None | -4 | 5 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/j.bmcl.2013.01.025 | ||||
| 44314783 | 173228 | 0 | None | 7943 | 2 | Pig | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1576 | 47 | 19 | 18 | 0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 77282213 | 173228 | 0 | None | 7943 | 2 | Pig | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1576 | 47 | 19 | 18 | 0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL427778 | 173228 | 0 | None | 7943 | 2 | Pig | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1576 | 47 | 19 | 18 | 0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 44311728 | 111130 | 0 | None | 13 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 653 | 12 | 3 | 7 | 4.4 | C=CS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL310039 | 111130 | 0 | None | 13 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 653 | 12 | 3 | 7 | 4.4 | C=CS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311701 | 174935 | 1 | None | 213 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 564 | 10 | 3 | 5 | 4.9 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL433106 | 174935 | 1 | None | 213 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 564 | 10 | 3 | 5 | 4.9 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311700 | 109599 | 0 | None | 234 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 579 | 10 | 3 | 4 | 6.0 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccsc3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL305462 | 109599 | 0 | None | 234 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 579 | 10 | 3 | 4 | 6.0 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccsc3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311692 | 109943 | 0 | None | 3 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 667 | 13 | 3 | 7 | 4.5 | C=CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL308102 | 109943 | 0 | None | 3 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 667 | 13 | 3 | 7 | 4.5 | C=CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311803 | 211333 | 0 | None | 26 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 699 | 15 | 3 | 8 | 4.3 | CCOCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL72924 | 211333 | 0 | None | 26 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 699 | 15 | 3 | 8 | 4.3 | CCOCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311804 | 109795 | 0 | None | 12 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 683 | 14 | 3 | 7 | 5.1 | CCCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL306950 | 109795 | 0 | None | 12 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 683 | 14 | 3 | 7 | 5.1 | CCCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311727 | 211248 | 0 | None | 9 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 669 | 13 | 3 | 7 | 4.7 | CCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL72348 | 211248 | 0 | None | 9 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 669 | 13 | 3 | 7 | 4.7 | CCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44314820 | 162500 | 0 | None | 380 | 2 | Pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1518 | 45 | 18 | 17 | 1.0 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 77282210 | 162500 | 0 | None | 380 | 2 | Pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1518 | 45 | 18 | 17 | 1.0 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL405377 | 162500 | 0 | None | 380 | 2 | Pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1518 | 45 | 18 | 17 | 1.0 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 44311915 | 111568 | 0 | None | 6 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 703 | 12 | 3 | 7 | 5.4 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)c2ccccc2)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL310920 | 111568 | 0 | None | 6 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 703 | 12 | 3 | 7 | 5.4 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)c2ccccc2)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311805 | 211345 | 0 | None | 26 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 669 | 12 | 3 | 7 | 4.7 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)C(C)C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL73000 | 211345 | 0 | None | 26 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 669 | 12 | 3 | 7 | 4.7 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)C(C)C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311838 | 211397 | 0 | None | 13 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 655 | 12 | 3 | 7 | 4.3 | CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL73373 | 211397 | 0 | None | 13 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 655 | 12 | 3 | 7 | 4.3 | CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311726 | 109862 | 0 | None | 10 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 667 | 12 | 3 | 7 | 4.8 | C/C=C/S(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL307471 | 109862 | 0 | None | 10 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 667 | 12 | 3 | 7 | 4.8 | C/C=C/S(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311772 | 109810 | 0 | None | 10 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 628 | 15 | 2 | 8 | 4.1 | CCCCS(=O)(=O)NC(=O)C(CCSC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL307045 | 109810 | 0 | None | 10 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 628 | 15 | 2 | 8 | 4.1 | CCCCS(=O)(=O)NC(=O)C(CCSC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311850 | 109968 | 0 | None | 10 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 717 | 13 | 3 | 7 | 5.5 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)Cc2ccccc2)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL308269 | 109968 | 0 | None | 10 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 717 | 13 | 3 | 7 | 5.5 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)Cc2ccccc2)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311849 | 109850 | 0 | None | 5 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 694 | 14 | 2 | 7 | 5.8 | CCCCS(=O)(=O)NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL307384 | 109850 | 0 | None | 5 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 694 | 14 | 2 | 7 | 5.8 | CCCCS(=O)(=O)NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311852 | 109861 | 0 | None | 144 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 579 | 10 | 3 | 4 | 6.0 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3cccs3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL307470 | 109861 | 0 | None | 144 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 579 | 10 | 3 | 4 | 6.0 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3cccs3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311773 | 211457 | 0 | None | 7 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 582 | 13 | 2 | 7 | 3.8 | CCCCS(=O)(=O)NC(=O)C(CC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL73835 | 211457 | 0 | None | 7 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 582 | 13 | 2 | 7 | 3.8 | CCCCS(=O)(=O)NC(=O)C(CC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311699 | 210948 | 0 | None | 331 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 563 | 10 | 3 | 4 | 5.5 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccco3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL70686 | 210948 | 0 | None | 331 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 563 | 10 | 3 | 4 | 5.5 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccco3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311851 | 211442 | 0 | None | 162 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 564 | 10 | 3 | 5 | 4.9 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccon3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL73697 | 211442 | 0 | None | 162 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 564 | 10 | 3 | 5 | 4.9 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccon3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44314607 | 168040 | 0 | None | 1412 | 2 | Pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1534 | 46 | 19 | 18 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 77282208 | 168040 | 0 | None | 1412 | 2 | Pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1534 | 46 | 19 | 18 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL412003 | 168040 | 0 | None | 1412 | 2 | Pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1534 | 46 | 19 | 18 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 3887 | 8853 | 45 | None | 7 | 4 | Pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(96)00421-0 | ||||
| 5311192 | 8853 | 45 | None | 7 | 4 | Pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(96)00421-0 | ||||
| CHEMBL72410 | 8853 | 45 | None | 7 | 4 | Pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(96)00421-0 | ||||
| 44314832 | 168052 | 0 | None | 251 | 2 | Pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 1496 | 45 | 18 | 17 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL412065 | 168052 | 0 | None | 251 | 2 | Pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 1496 | 45 | 18 | 17 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 3887 | 8853 | 45 | None | -7 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00387-4 | ||||
| 5311192 | 8853 | 45 | None | -7 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00387-4 | ||||
| CHEMBL72410 | 8853 | 45 | None | -7 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00387-4 | ||||
| 9938533 | 112190 | 4 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 596 | 13 | 2 | 7 | 4.0 | CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL311854 | 112190 | 4 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 596 | 13 | 2 | 7 | 4.0 | CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C | 10.1016/s0960-894x(98)00387-4 | ||
| 9938533 | 112190 | 4 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 596 | 13 | 2 | 7 | 4.0 | CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C | 10.1016/s0960-894x(98)00388-6 | ||
| CHEMBL311854 | 112190 | 4 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 596 | 13 | 2 | 7 | 4.0 | CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C | 10.1016/s0960-894x(98)00388-6 | ||
| 46228117 | 206563 | 0 | None | -1 | 2 | Mouse | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 690 | 13 | 1 | 12 | 4.7 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOc3ccc(S(C)(=O)=O)cc3)c2)cc1 | 10.1016/j.bmc.2009.08.058 | ||
| CHEMBL593928 | 206563 | 0 | None | -1 | 2 | Mouse | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 690 | 13 | 1 | 12 | 4.7 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOc3ccc(S(C)(=O)=O)cc3)c2)cc1 | 10.1016/j.bmc.2009.08.058 | ||
| 44311763 | 211228 | 0 | None | 6 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 610 | 14 | 2 | 7 | 4.4 | CCCCS(=O)(=O)NC(=O)C(CC(C)C)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL72217 | 211228 | 0 | None | 6 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 610 | 14 | 2 | 7 | 4.4 | CCCCS(=O)(=O)NC(=O)C(CC(C)C)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 9953358 | 101575 | 13 | None | -102 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm030480f | ||
| CHEMBL25344 | 101575 | 13 | None | -102 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm030480f | ||
| 9953358 | 101575 | 13 | None | -102 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| CHEMBL25344 | 101575 | 13 | None | -102 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| 10599129 | 109013 | 0 | None | -5 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 438 | 9 | 1 | 7 | 3.5 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(C)cc2)c2ccc(C)cc2)n1 | 10.1021/jm960274q | ||
| CHEMBL303034 | 109013 | 0 | None | -5 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 438 | 9 | 1 | 7 | 3.5 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(C)cc2)c2ccc(C)cc2)n1 | 10.1021/jm960274q | ||
| 10737908 | 48225 | 0 | None | -102 | 2 | Rat | 4.0 | pKi | = | 4 | Binding | ChEMBL | 370 | 6 | 1 | 4 | 4.6 | Cc1cnoc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 | 10.1021/jm970872k | ||
| CHEMBL149060 | 48225 | 0 | None | -102 | 2 | Rat | 4.0 | pKi | = | 4 | Binding | ChEMBL | 370 | 6 | 1 | 4 | 4.6 | Cc1cnoc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 | 10.1021/jm970872k | ||
| 10835335 | 11609 | 0 | None | -50118 | 2 | Human | 4.0 | pKi | = | 4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.7 | Cc1coc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 | 10.1021/jm000105c | ||
| CHEMBL104223 | 11609 | 0 | None | -50118 | 2 | Human | 4.0 | pKi | = | 4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.7 | Cc1coc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 | 10.1021/jm000105c | ||
| 10321341 | 152214 | 0 | None | -93 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 446 | 7 | 1 | 5 | 5.2 | CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1021/jm00037a003 | ||
| CHEMBL39142 | 152214 | 0 | None | -93 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 446 | 7 | 1 | 5 | 5.2 | CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1021/jm00037a003 | ||
| 11762890 | 107439 | 0 | None | -14791 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 505 | 8 | 2 | 9 | 5.3 | Cc1cc(NCc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)no1 | 10.1021/jm020289q | ||
| CHEMBL29223 | 107439 | 0 | None | -14791 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 505 | 8 | 2 | 9 | 5.3 | Cc1cc(NCc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)no1 | 10.1021/jm020289q | ||
| 44314444 | 168501 | 0 | None | 457 | 2 | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1470 | 45 | 18 | 17 | -0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL413604 | 168501 | 0 | None | 457 | 2 | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1470 | 45 | 18 | 17 | -0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 178103 | 174730 | 14 | None | -100 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 506 | 10 | 2 | 7 | 4.6 | CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1021/jm970101g | ||
| CHEMBL431651 | 174730 | 14 | None | -100 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 506 | 10 | 2 | 7 | 4.6 | CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1021/jm970101g | ||
| 10763862 | 169996 | 0 | None | -1096 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 406 | 9 | 1 | 5 | 4.0 | CCc1cc(CC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| CHEMBL418326 | 169996 | 0 | None | -1096 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 406 | 9 | 1 | 5 | 4.0 | CCc1cc(CC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| 10907333 | 108859 | 0 | None | -1819 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 508 | 7 | 2 | 7 | 4.9 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)NC(C)(C)C)c1C | 10.1021/jm020289q | ||
| CHEMBL30215 | 108859 | 0 | None | -1819 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 508 | 7 | 2 | 7 | 4.9 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)NC(C)(C)C)c1C | 10.1021/jm020289q | ||
| 19934535 | 113752 | 0 | None | 7 | 2 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 468 | 6 | 3 | 4 | 5.0 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3c[nH]c4ccccc34)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| CHEMBL315096 | 113752 | 0 | None | 7 | 2 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 468 | 6 | 3 | 4 | 5.0 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3c[nH]c4ccccc34)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| 11812665 | 106544 | 0 | None | -18197 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 467 | 8 | 1 | 7 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COC(C)C)c1C | 10.1021/jm020289q | ||
| CHEMBL285118 | 106544 | 0 | None | -18197 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 467 | 8 | 1 | 7 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COC(C)C)c1C | 10.1021/jm020289q | ||
| 178103 | 174730 | 14 | None | -100 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 506 | 10 | 2 | 7 | 4.6 | CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1021/jm980217s | ||
| CHEMBL431651 | 174730 | 14 | None | -100 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 506 | 10 | 2 | 7 | 4.6 | CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | 10.1021/jm980217s | ||
| 10553793 | 11233 | 0 | None | -75 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 512 | 11 | 2 | 6 | 4.8 | Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(C(=O)O)cc2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm9910425 | ||
| CHEMBL101742 | 11233 | 0 | None | -75 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 512 | 11 | 2 | 6 | 4.8 | Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(C(=O)O)cc2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm9910425 | ||
| 10813050 | 50827 | 0 | None | -602 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 441 | 9 | 2 | 5 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CNC=O)c1C | 10.1021/jm970872k | ||
| CHEMBL151440 | 50827 | 0 | None | -602 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 441 | 9 | 2 | 5 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CNC=O)c1C | 10.1021/jm970872k | ||
| 9830098 | 109807 | 0 | None | 5 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 596 | 13 | 2 | 7 | 4.0 | CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C | 10.1016/s0960-894x(98)00388-6 | ||
| CHEMBL307033 | 109807 | 0 | None | 5 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 596 | 13 | 2 | 7 | 4.0 | CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C | 10.1016/s0960-894x(98)00388-6 | ||
| 44312023 | 211243 | 0 | None | 22 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 596 | 13 | 2 | 7 | 4.0 | CCCCS(=O)(=O)NC(=O)[C@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C | 10.1016/s0960-894x(98)00388-6 | ||
| CHEMBL72295 | 211243 | 0 | None | 22 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 596 | 13 | 2 | 7 | 4.0 | CCCCS(=O)(=O)NC(=O)[C@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C | 10.1016/s0960-894x(98)00388-6 | ||
| 10984658 | 107628 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 570 | 10 | 1 | 7 | 6.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CCc2ccccc2)c1C | 10.1021/jm020289q | ||
| CHEMBL29346 | 107628 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 570 | 10 | 1 | 7 | 6.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CCc2ccccc2)c1C | 10.1021/jm020289q | ||
| 10812403 | 45874 | 0 | None | -120 | 2 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 427 | 7 | 2 | 5 | 4.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(N)=O)c1C | 10.1021/jm970872k | ||
| CHEMBL146904 | 45874 | 0 | None | -120 | 2 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 427 | 7 | 2 | 5 | 4.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(N)=O)c1C | 10.1021/jm970872k | ||
| 10668819 | 127892 | 0 | None | -602 | 2 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 402 | 6 | 1 | 4 | 5.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2F)c1C | 10.1021/jm970872k | ||
| CHEMBL357395 | 127892 | 0 | None | -602 | 2 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 402 | 6 | 1 | 4 | 5.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2F)c1C | 10.1021/jm970872k | ||
| 10742502 | 128045 | 0 | None | -134 | 2 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 457 | 9 | 3 | 6 | 4.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCC(=O)O)c1C | 10.1021/jm970872k | ||
| CHEMBL357823 | 128045 | 0 | None | -134 | 2 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 457 | 9 | 3 | 6 | 4.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCC(=O)O)c1C | 10.1021/jm970872k | ||
| 19934549 | 112770 | 0 | None | 3 | 2 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 439 | 6 | 2 | 3 | 5.4 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(Cc3c[nH]c4ccccc34)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| CHEMBL313184 | 112770 | 0 | None | 3 | 2 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 439 | 6 | 2 | 3 | 5.4 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(Cc3c[nH]c4ccccc34)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| 10740953 | 12088 | 0 | None | -758 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 423 | 5 | 1 | 6 | 5.0 | Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)oc1C | 10.1021/jm000105c | ||
| CHEMBL106749 | 12088 | 0 | None | -758 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 423 | 5 | 1 | 6 | 5.0 | Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)oc1C | 10.1021/jm000105c | ||
| 10740258 | 116455 | 0 | None | -1096 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.7 | Cc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)o1 | 10.1021/jm000105c | ||
| CHEMBL322674 | 116455 | 0 | None | -1096 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.7 | Cc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)o1 | 10.1021/jm000105c | ||
| 9938571 | 16369 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| CHEMBL112531 | 16369 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| CHEMBL369489 | 16369 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 597 | 9 | 1 | 8 | 5.6 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| 11801906 | 105304 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 612 | 13 | 1 | 8 | 6.2 | COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 | 10.1021/jm9910425 | ||
| CHEMBL276288 | 105304 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 612 | 13 | 1 | 8 | 6.2 | COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 | 10.1021/jm9910425 | ||
| 10501931 | 50647 | 0 | None | -64 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 414 | 7 | 2 | 5 | 4.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CO)c1C | 10.1021/jm970872k | ||
| CHEMBL151160 | 50647 | 0 | None | -64 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 414 | 7 | 2 | 5 | 4.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CO)c1C | 10.1021/jm970872k | ||
| 10719157 | 109072 | 0 | None | -58 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 470 | 11 | 1 | 9 | 2.9 | COc1cccc(C(OC)(c2cccc(OC)c2)C(Oc2nc(OC)cc(OC)n2)C(=O)O)c1 | 10.1021/jm960274q | ||
| CHEMBL303390 | 109072 | 0 | None | -58 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 470 | 11 | 1 | 9 | 2.9 | COc1cccc(C(OC)(c2cccc(OC)c2)C(Oc2nc(OC)cc(OC)n2)C(=O)O)c1 | 10.1021/jm960274q | ||
| 10552683 | 209890 | 0 | None | -5 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 478 | 9 | 1 | 7 | 4.2 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 | 10.1021/jm960274q | ||
| CHEMBL64009 | 209890 | 0 | None | -5 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 478 | 9 | 1 | 7 | 4.2 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 | 10.1021/jm960274q | ||
| 10670662 | 210227 | 0 | None | -53 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 438 | 9 | 1 | 7 | 3.5 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(C)c2)c2cccc(C)c2)n1 | 10.1021/jm960274q | ||
| CHEMBL65833 | 210227 | 0 | None | -53 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 438 | 9 | 1 | 7 | 3.5 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(C)c2)c2cccc(C)c2)n1 | 10.1021/jm960274q | ||
| 11103181 | 106160 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 507 | 7 | 1 | 7 | 4.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCN(C)C2=O)c1C | 10.1021/jm020289q | ||
| CHEMBL282628 | 106160 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 507 | 7 | 1 | 7 | 4.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCN(C)C2=O)c1C | 10.1021/jm020289q | ||
| 9915028 | 16183 | 18 | None | -28183 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL5212743 | ||
| CHEMBL111612 | 16183 | 18 | None | -28183 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL5212743 | ||
| CHEMBL4761843 | 16183 | 18 | None | -28183 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.6019/CHEMBL5212743 | ||
| 9915028 | 16183 | 18 | None | -28183 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| CHEMBL111612 | 16183 | 18 | None | -28183 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| CHEMBL4761843 | 16183 | 18 | None | -28183 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 532 | 15 | 1 | 6 | 5.5 | CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC | 10.1021/jm980217s | ||
| 9914310 | 213422 | 8 | None | -1995 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| CHEMBL8923 | 213422 | 8 | None | -1995 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 510 | 12 | 1 | 6 | 4.7 | CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 | 10.1021/jm9505369 | ||
| 9870830 | 213493 | 38 | None | -66 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9505369 | ||
| CHEMBL8981 | 213493 | 38 | None | -66 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 506 | 8 | 1 | 9 | 3.8 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm9505369 | ||
| 23670447 | 9803 | 2 | None | -114 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm980217s | ||
| 999 | 9803 | 2 | None | -114 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm980217s | ||
| CHEMBL1204799 | 9803 | 2 | None | -114 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm980217s | ||
| CHEMBL25438 | 9803 | 2 | None | -114 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 528 | 10 | 0 | 9 | 0.1 | COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] | 10.1021/jm980217s | ||
| 9849547 | 190785 | 0 | None | -34 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(=O)O)[C@@H](C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | ||
| CHEMBL48196 | 190785 | 0 | None | -34 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(=O)O)[C@@H](C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 | 10.1016/s0960-894x(01)00273-6 | ||
| 10768897 | 114434 | 1 | None | -6 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 544 | 13 | 1 | 8 | 4.8 | COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm9910425 | ||
| CHEMBL319031 | 114434 | 1 | None | -6 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 544 | 13 | 1 | 8 | 4.8 | COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm9910425 | ||
| 108002 | 10267 | 23 | None | -56 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 10.1021/jm00037a003 | ||
| 3528 | 10267 | 23 | None | -56 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 10.1021/jm00037a003 | ||
| CHEMBL8823 | 10267 | 23 | None | -56 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 10.1021/jm00037a003 | ||
| 108002 | 10267 | 23 | None | -56 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 10.1021/jm9505369 | ||
| 3528 | 10267 | 23 | None | -56 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 10.1021/jm9505369 | ||
| CHEMBL8823 | 10267 | 23 | None | -56 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 10.1021/jm9505369 | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm000538f | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm000538f | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm000538f | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm000538f | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm000538f | ||
| 10741151 | 49841 | 0 | None | -223 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 5.4 | CCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| CHEMBL150474 | 49841 | 0 | None | -223 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 5.4 | CCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| 10743346 | 109388 | 0 | None | -4 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 480 | 11 | 1 | 7 | 4.7 | COc1cc(OC)nc(OC(C(=O)O)C(OCCC(C)(C)C)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| CHEMBL304173 | 109388 | 0 | None | -4 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 480 | 11 | 1 | 7 | 4.7 | COc1cc(OC)nc(OC(C(=O)O)C(OCCC(C)(C)C)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| 10941181 | 106121 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 624 | 9 | 1 | 7 | 6.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccc(C(F)(F)F)cc2)c1C | 10.1021/jm020289q | ||
| CHEMBL282336 | 106121 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 624 | 9 | 1 | 7 | 6.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccc(C(F)(F)F)cc2)c1C | 10.1021/jm020289q | ||
| 11730445 | 108685 | 0 | None | -4677 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 475 | 7 | 1 | 8 | 4.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2cccn2)c1C | 10.1021/jm020289q | ||
| CHEMBL30092 | 108685 | 0 | None | -4677 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 475 | 7 | 1 | 8 | 4.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2cccn2)c1C | 10.1021/jm020289q | ||
| 9807200 | 92120 | 0 | None | -346 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 3.6 | COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261359 | 92120 | 0 | None | -346 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 3.6 | COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 | 10.1007/s00044-004-0021-y | ||
| 10918301 | 108273 | 0 | None | -7585 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 514 | 8 | 1 | 7 | 6.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)c2ccccc2)c1C | 10.1021/jm020289q | ||
| CHEMBL29793 | 108273 | 0 | None | -7585 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 514 | 8 | 1 | 7 | 6.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)c2ccccc2)c1C | 10.1021/jm020289q | ||
| 10620185 | 126429 | 0 | None | -89 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 4.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL346853 | 126429 | 0 | None | -89 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 4.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 10814297 | 210308 | 0 | None | -17 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 472 | 10 | 1 | 7 | 4.3 | COc1cc(OC)nc(OC(C(=O)O)C(Oc2ccccc2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| CHEMBL66402 | 210308 | 0 | None | -17 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 472 | 10 | 1 | 7 | 4.3 | COc1cc(OC)nc(OC(C(=O)O)C(Oc2ccccc2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| 11124425 | 106640 | 0 | None | -75857 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 543 | 7 | 1 | 8 | 5.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccc(C(F)(F)F)n2)c1C | 10.1021/jm020289q | ||
| CHEMBL285832 | 106640 | 0 | None | -75857 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 543 | 7 | 1 | 8 | 5.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccc(C(F)(F)F)n2)c1C | 10.1021/jm020289q | ||
| 10595347 | 49255 | 0 | None | -537 | 2 | Rat | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 370 | 6 | 1 | 4 | 4.7 | CCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm970872k | ||
| CHEMBL149953 | 49255 | 0 | None | -537 | 2 | Rat | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 370 | 6 | 1 | 4 | 4.7 | CCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm970872k | ||
| 10691439 | 51317 | 0 | None | -245 | 2 | Rat | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 384 | 4 | 1 | 4 | 5.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL151971 | 51317 | 0 | None | -245 | 2 | Rat | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 384 | 4 | 1 | 4 | 5.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 76312118 | 92122 | 0 | None | -691 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 522 | 7 | 2 | 8 | 3.4 | COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 | 10.1007/s00044-004-0021-y | ||
| CHEMBL2261361 | 92122 | 0 | None | -691 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 522 | 7 | 2 | 8 | 3.4 | COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 | 10.1007/s00044-004-0021-y | ||
| 9863132 | 170089 | 0 | None | - | 1 | Pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 348 | 6 | 3 | 2 | 3.1 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C1CC1c1ccccc1 | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL418898 | 170089 | 0 | None | - | 1 | Pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 348 | 6 | 3 | 2 | 3.1 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C1CC1c1ccccc1 | 10.1016/0960-894X(96)00421-0 | ||
| 10528863 | 11392 | 0 | None | -4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 484 | 10 | 2 | 6 | 4.8 | Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(O)cc2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm9910425 | ||
| CHEMBL102868 | 11392 | 0 | None | -4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 484 | 10 | 2 | 6 | 4.8 | Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(O)cc2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm9910425 | ||
| 10786696 | 109564 | 0 | None | -223 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 392 | 8 | 1 | 5 | 3.8 | CCc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| CHEMBL305270 | 109564 | 0 | None | -223 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 392 | 8 | 1 | 5 | 3.8 | CCc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| 10603135 | 116521 | 0 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 570 | 14 | 1 | 7 | 6.0 | CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| CHEMBL322996 | 116521 | 0 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 570 | 14 | 1 | 7 | 6.0 | CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| 10503421 | 126287 | 0 | None | -245 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 443 | 9 | 3 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCCO)c1C | 10.1021/jm970872k | ||
| CHEMBL345542 | 126287 | 0 | None | -245 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 443 | 9 | 3 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCCO)c1C | 10.1021/jm970872k | ||
| 9822616 | 128770 | 0 | None | -17782 | 2 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncccn3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL359273 | 128770 | 0 | None | -17782 | 2 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncccn3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| 46228086 | 206613 | 0 | None | -707 | 2 | Mouse | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 598 | 10 | 1 | 9 | 4.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCBr)c2)cc1 | 10.1016/j.bmc.2009.08.058 | ||
| CHEMBL594265 | 206613 | 0 | None | -707 | 2 | Mouse | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 598 | 10 | 1 | 9 | 4.6 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCBr)c2)cc1 | 10.1016/j.bmc.2009.08.058 | ||
| 10505434 | 11438 | 0 | None | -7 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 496 | 11 | 1 | 5 | 5.8 | Cc1ccc(CCCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| CHEMBL103190 | 11438 | 0 | None | -7 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 496 | 11 | 1 | 5 | 5.8 | Cc1ccc(CCCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| 10691437 | 11854 | 0 | None | -95 | 4 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL105490 | 11854 | 0 | None | -95 | 4 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 9908909 | 12081 | 11 | None | -363 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 399 | 6 | 2 | 5 | 4.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N)c1C | 10.1021/jm970872k | ||
| CHEMBL106684 | 12081 | 11 | None | -363 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 399 | 6 | 2 | 5 | 4.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N)c1C | 10.1021/jm970872k | ||
| 11797288 | 210395 | 0 | None | -89 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 438 | 11 | 1 | 7 | 3.7 | CCCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O | 10.1021/jm960274q | ||
| CHEMBL67084 | 210395 | 0 | None | -89 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 438 | 11 | 1 | 7 | 3.7 | CCCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O | 10.1021/jm960274q | ||
| 10691437 | 11854 | 0 | None | -95 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm000105c | ||
| CHEMBL105490 | 11854 | 0 | None | -95 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm000105c | ||
| 11081276 | 108000 | 0 | None | -2238 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cc2ncco2)c1C | 10.1021/jm020289q | ||
| CHEMBL29598 | 108000 | 0 | None | -2238 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cc2ncco2)c1C | 10.1021/jm020289q | ||
| 10864118 | 108245 | 0 | None | -4265 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 508 | 8 | 1 | 7 | 5.2 | CC(=O)N(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)C(C)C | 10.1021/jm020289q | ||
| CHEMBL29775 | 108245 | 0 | None | -4265 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 508 | 8 | 1 | 7 | 5.2 | CC(=O)N(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)C(C)C | 10.1021/jm020289q | ||
| 10667808 | 126069 | 0 | None | -338 | 2 | Rat | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 4.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(NC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL343867 | 126069 | 0 | None | -338 | 2 | Rat | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 4.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(NC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 12286 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1021/jm980217s | ||
| 6433095 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1021/jm980217s | ||
| CHEMBL109648 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1021/jm980217s | ||
| DB06677 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 10.1021/jm980217s | ||
| 108002 | 10267 | 23 | None | -56 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 10.1021/jm970101g | ||
| 3528 | 10267 | 23 | None | -56 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 10.1021/jm970101g | ||
| CHEMBL8823 | 10267 | 23 | None | -56 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 10 | 2 | 7 | 4.7 | CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC | 10.1021/jm970101g | ||
| 44314884 | 167531 | 0 | None | - | 1 | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1520 | 45 | 19 | 18 | -0.6 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(96)00421-0 | ||
| 77282209 | 167531 | 0 | None | - | 1 | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1520 | 45 | 19 | 18 | -0.6 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL411399 | 167531 | 0 | None | - | 1 | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1520 | 45 | 19 | 18 | -0.6 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(96)00421-0 | ||
| 10742005 | 210476 | 0 | None | -162 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 446 | 9 | 1 | 7 | 3.2 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(F)c2)c2cccc(F)c2)n1 | 10.1021/jm960274q | ||
| CHEMBL67536 | 210476 | 0 | None | -162 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 446 | 9 | 1 | 7 | 3.2 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(F)c2)c2cccc(F)c2)n1 | 10.1021/jm960274q | ||
| 13016 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1016/s0960-894x(01)00791-0 | ||
| 9843631 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL24461 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1016/s0960-894x(01)00791-0 | ||
| 13016 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1021/jm000105c | ||
| 9843631 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1021/jm000105c | ||
| CHEMBL24461 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1021/jm000105c | ||
| 13016 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1021/jm020289q | ||
| 9843631 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1021/jm020289q | ||
| CHEMBL24461 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1021/jm020289q | ||
| 9865409 | 109106 | 0 | None | -199 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 394 | 8 | 1 | 6 | 3.2 | COc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| CHEMBL303631 | 109106 | 0 | None | -199 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 394 | 8 | 1 | 6 | 3.2 | COc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| 10691438 | 51266 | 0 | None | -51 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 384 | 7 | 1 | 4 | 5.1 | CCCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm970872k | ||
| CHEMBL151926 | 51266 | 0 | None | -51 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 384 | 7 | 1 | 4 | 5.1 | CCCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm970872k | ||
| 10718666 | 128299 | 0 | None | -3 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 457 | 9 | 3 | 6 | 4.5 | Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL358461 | 128299 | 0 | None | -3 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 457 | 9 | 3 | 6 | 4.5 | Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 5122650 | 109708 | 5 | None | -100 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 364 | 7 | 1 | 5 | 3.2 | COC(c1ccccc1)(c1ccccc1)C(Oc1nccc(C)n1)C(=O)O | 10.1021/jm960274q | ||
| CHEMBL306218 | 109708 | 5 | None | -100 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 364 | 7 | 1 | 5 | 3.2 | COC(c1ccccc1)(c1ccccc1)C(Oc1nccc(C)n1)C(=O)O | 10.1021/jm960274q | ||
| 13016 | 7457 | 13 | None | -1348 | 4 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1016/j.bmcl.2016.06.014 | ||
| 9843631 | 7457 | 13 | None | -1348 | 4 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL24461 | 7457 | 13 | None | -1348 | 4 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10.1016/j.bmcl.2016.06.014 | ||
| 11113812 | 107573 | 0 | None | -1258 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 497 | 7 | 1 | 6 | 6.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C\c2ccccc2)c1C | 10.1021/jm020289q | ||
| CHEMBL29313 | 107573 | 0 | None | -1258 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 497 | 7 | 1 | 6 | 6.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C\c2ccccc2)c1C | 10.1021/jm020289q | ||
| 11103326 | 174684 | 0 | None | -12589 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 520 | 8 | 1 | 7 | 5.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)CC(F)(F)F)c1C | 10.1021/jm020289q | ||
| CHEMBL431296 | 174684 | 0 | None | -12589 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 520 | 8 | 1 | 7 | 5.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)CC(F)(F)F)c1C | 10.1021/jm020289q | ||
| 10620897 | 48390 | 0 | None | -14 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 398 | 6 | 1 | 4 | 5.3 | Cc1cccc(-c2ccc(CC(C)C)cc2)c1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| CHEMBL149171 | 48390 | 0 | None | -14 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 398 | 6 | 1 | 4 | 5.3 | Cc1cccc(-c2ccc(CC(C)C)cc2)c1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| 10761688 | 126633 | 0 | None | -380 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 370 | 5 | 1 | 4 | 4.9 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL348700 | 126633 | 0 | None | -380 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 370 | 5 | 1 | 4 | 4.9 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 10810897 | 128271 | 0 | None | -3801 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 398 | 6 | 1 | 4 | 5.3 | Cc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| CHEMBL358254 | 128271 | 0 | None | -3801 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 398 | 6 | 1 | 4 | 5.3 | Cc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| 197712 | 108957 | 57 | None | -194 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC(c1ccccc1)(c1ccccc1)C(Oc1nc(C)cc(C)n1)C(=O)O | 10.1021/jm960274q | ||
| CHEMBL302753 | 108957 | 57 | None | -194 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 378 | 7 | 1 | 5 | 3.5 | COC(c1ccccc1)(c1ccccc1)C(Oc1nc(C)cc(C)n1)C(=O)O | 10.1021/jm960274q | ||
| 10721484 | 114138 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 554 | 13 | 1 | 6 | 6.3 | CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| CHEMBL317716 | 114138 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 554 | 13 | 1 | 6 | 6.3 | CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| 10793160 | 105182 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 570 | 13 | 1 | 8 | 5.6 | COc1cc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC | 10.1021/jm9910425 | ||
| CHEMBL275471 | 105182 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 570 | 13 | 1 | 8 | 5.6 | COc1cc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC | 10.1021/jm9910425 | ||
| 10432263 | 108929 | 0 | None | -85 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 420 | 8 | 1 | 6 | 3.4 | COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCC2 | 10.1021/jm960274q | ||
| CHEMBL302564 | 108929 | 0 | None | -85 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 420 | 8 | 1 | 6 | 3.4 | COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCC2 | 10.1021/jm960274q | ||
| 10549727 | 171666 | 0 | None | -125 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 5.0 | COc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1-c1ccc(CC(C)C)cc1 | 10.1021/jm970872k | ||
| CHEMBL422128 | 171666 | 0 | None | -125 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 5.0 | COc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1-c1ccc(CC(C)C)cc1 | 10.1021/jm970872k | ||
| 10762600 | 175081 | 0 | None | -154 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 5.0 | Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL434082 | 175081 | 0 | None | -154 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 5.0 | Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 10620958 | 48483 | 0 | None | -331 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 399 | 6 | 1 | 5 | 4.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL149241 | 48483 | 0 | None | -331 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 399 | 6 | 1 | 5 | 4.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 44365561 | 49044 | 0 | None | -524 | 2 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 404 | 5 | 1 | 4 | 5.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccc3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL149763 | 49044 | 0 | None | -524 | 2 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 404 | 5 | 1 | 4 | 5.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccc3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| 19085510 | 126333 | 0 | None | -6025 | 2 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 4.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccnc3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL345951 | 126333 | 0 | None | -6025 | 2 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 4.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccnc3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| 11794992 | 11744 | 0 | None | -39810 | 2 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cocn3)cc2)c1C | 10.1021/jm000105c | ||
| CHEMBL104848 | 11744 | 0 | None | -39810 | 2 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cocn3)cc2)c1C | 10.1021/jm000105c | ||
| 10668636 | 128750 | 0 | None | -147 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 399 | 6 | 2 | 5 | 4.5 | Cc1noc(NS(=O)(=O)c2ccc(N)cc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL359167 | 128750 | 0 | None | -147 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 399 | 6 | 2 | 5 | 4.5 | Cc1noc(NS(=O)(=O)c2ccc(N)cc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 10508342 | 11502 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 638 | 13 | 1 | 8 | 6.3 | COc1ccc(CCOC(c2ccc(Cl)cc2)(c2ccc(Cl)cc2)C(Oc2nc3c(c(OC)n2)CCC3)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| CHEMBL103605 | 11502 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 638 | 13 | 1 | 8 | 6.3 | COc1ccc(CCOC(c2ccc(Cl)cc2)(c2ccc(Cl)cc2)C(Oc2nc3c(c(OC)n2)CCC3)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| 10740469 | 46079 | 0 | None | -154 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 413 | 7 | 2 | 5 | 5.0 | CNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| CHEMBL147081 | 46079 | 0 | None | -154 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 413 | 7 | 2 | 5 | 5.0 | CNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| 18660520 | 46338 | 0 | None | -3548 | 2 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnccn3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL147340 | 46338 | 0 | None | -3548 | 2 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnccn3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| 11799974 | 11303 | 0 | None | -12 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 514 | 12 | 1 | 7 | 4.8 | COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| CHEMBL102307 | 11303 | 0 | None | -12 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 514 | 12 | 1 | 7 | 4.8 | COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| 3921421 | 114076 | 8 | None | -9 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 468 | 10 | 1 | 5 | 5.1 | Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccccc2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm9910425 | ||
| CHEMBL317233 | 114076 | 8 | None | -9 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 468 | 10 | 1 | 5 | 5.1 | Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccccc2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm9910425 | ||
| 10670965 | 49100 | 0 | None | -851 | 2 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.3 | Cc1noc(NS(=O)(=O)c2cccc(OCCO)c2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL149819 | 49100 | 0 | None | -851 | 2 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.3 | Cc1noc(NS(=O)(=O)c2cccc(OCCO)c2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 11006149 | 107875 | 0 | None | -380 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 550 | 8 | 1 | 7 | 6.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)(C)C)C(C)C)c1C | 10.1021/jm020289q | ||
| CHEMBL29502 | 107875 | 0 | None | -380 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 550 | 8 | 1 | 7 | 6.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)(C)C)C(C)C)c1C | 10.1021/jm020289q | ||
| 10521258 | 128074 | 0 | None | -416 | 2 | Rat | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 342 | 4 | 1 | 4 | 4.1 | Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm970872k | ||
| CHEMBL358020 | 128074 | 0 | None | -416 | 2 | Rat | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 342 | 4 | 1 | 4 | 4.1 | Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm970872k | ||
| 44311810 | 111567 | 0 | None | 35 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 596 | 13 | 2 | 7 | 4.0 | CCCCS(=O)(=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C | 10.1016/s0960-894x(98)00388-6 | ||
| CHEMBL310919 | 111567 | 0 | None | 35 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 596 | 13 | 2 | 7 | 4.0 | CCCCS(=O)(=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C | 10.1016/s0960-894x(98)00388-6 | ||
| 10555112 | 11509 | 0 | None | -12 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 572 | 14 | 2 | 8 | 4.6 | COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)ccc1OCC(=O)O | 10.1021/jm9910425 | ||
| CHEMBL103695 | 11509 | 0 | None | -12 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 572 | 14 | 2 | 8 | 4.6 | COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)ccc1OCC(=O)O | 10.1021/jm9910425 | ||
| 10648996 | 11126 | 0 | None | -3 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 498 | 11 | 1 | 6 | 5.1 | COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| CHEMBL101069 | 11126 | 0 | None | -3 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 498 | 11 | 1 | 6 | 5.1 | COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| 9979632 | 109678 | 0 | None | -41 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 1 | 7 | 2.8 | COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCO2 | 10.1021/jm960274q | ||
| CHEMBL305980 | 109678 | 0 | None | -41 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 1 | 7 | 2.8 | COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCO2 | 10.1021/jm960274q | ||
| 45257114 | 206642 | 0 | None | -218 | 2 | Mouse | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 538 | 10 | 1 | 9 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 | 10.1021/jm101110w | ||
| CHEMBL594482 | 206642 | 0 | None | -218 | 2 | Mouse | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 538 | 10 | 1 | 9 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 | 10.1021/jm101110w | ||
| 45257114 | 206642 | 0 | None | -218 | 2 | Mouse | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 538 | 10 | 1 | 9 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 | 10.1016/j.bmc.2009.08.058 | ||
| CHEMBL594482 | 206642 | 0 | None | -218 | 2 | Mouse | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 538 | 10 | 1 | 9 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 | 10.1016/j.bmc.2009.08.058 | ||
| 10501166 | 48652 | 0 | None | -47 | 2 | Rat | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 400 | 6 | 2 | 5 | 4.7 | Cc1noc(NS(=O)(=O)c2cc(O)ccc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL149391 | 48652 | 0 | None | -47 | 2 | Rat | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 400 | 6 | 2 | 5 | 4.7 | Cc1noc(NS(=O)(=O)c2cc(O)ccc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 10407051 | 107169 | 0 | None | -5 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.7 | COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc(OC)cc3)[C@@H]2C(=O)O)cc1 | 10.1021/jm00037a003 | ||
| CHEMBL290026 | 107169 | 0 | None | -5 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.7 | COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc(OC)cc3)[C@@H]2C(=O)O)cc1 | 10.1021/jm00037a003 | ||
| 9937336 | 181458 | 1 | None | -229 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 510 | 9 | 1 | 7 | 4.8 | CCCc1nc(C)ccc1O[C@@H](C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL4559129 | 181458 | 1 | None | -229 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 510 | 9 | 1 | 7 | 4.8 | CCCc1nc(C)ccc1O[C@@H](C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2016.06.014 | ||
| 11800649 | 11381 | 0 | None | -7 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 542 | 13 | 1 | 7 | 5.5 | CCOc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| CHEMBL102797 | 11381 | 0 | None | -7 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 542 | 13 | 1 | 7 | 5.5 | CCOc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| 10693607 | 109483 | 0 | None | -354 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 424 | 10 | 1 | 7 | 3.3 | CCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O | 10.1021/jm960274q | ||
| CHEMBL304778 | 109483 | 0 | None | -354 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 424 | 10 | 1 | 7 | 3.3 | CCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O | 10.1021/jm960274q | ||
| 10836754 | 210369 | 0 | None | -14 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 438 | 11 | 1 | 7 | 3.7 | CCOc1cc(OCC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| CHEMBL66893 | 210369 | 0 | None | -14 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 438 | 11 | 1 | 7 | 3.7 | CCOc1cc(OCC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| 11124545 | 108150 | 0 | None | -4168 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 557 | 9 | 1 | 8 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccn2)c1C | 10.1021/jm020289q | ||
| CHEMBL29710 | 108150 | 0 | None | -4168 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 557 | 9 | 1 | 8 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccn2)c1C | 10.1021/jm020289q | ||
| 44314445 | 168039 | 0 | None | - | 1 | Pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 1486 | 45 | 19 | 18 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL412002 | 168039 | 0 | None | - | 1 | Pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 1486 | 45 | 19 | 18 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 10670204 | 48308 | 0 | None | -17 | 2 | Rat | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 428 | 7 | 2 | 5 | 4.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(=O)O)c1C | 10.1021/jm970872k | ||
| CHEMBL149111 | 48308 | 0 | None | -17 | 2 | Rat | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 428 | 7 | 2 | 5 | 4.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(=O)O)c1C | 10.1021/jm970872k | ||
| 11145758 | 108521 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 520 | 7 | 1 | 7 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCC(C)(C)C2=O)c1C | 10.1021/jm020289q | ||
| CHEMBL29972 | 108521 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 520 | 7 | 1 | 7 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCC(C)(C)C2=O)c1C | 10.1021/jm020289q | ||
| 10973218 | 107746 | 0 | None | -3388 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 506 | 8 | 2 | 7 | 5.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNCC(F)(F)F)c1C | 10.1021/jm020289q | ||
| CHEMBL29420 | 107746 | 0 | None | -3388 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 506 | 8 | 2 | 7 | 5.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNCC(F)(F)F)c1C | 10.1021/jm020289q | ||
| 10525034 | 126452 | 0 | None | -89 | 2 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 4.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL347125 | 126452 | 0 | None | -89 | 2 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 4.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 11734435 | 108079 | 0 | None | -6456 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 562 | 9 | 1 | 7 | 6.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC2CCCCC2)c1C | 10.1021/jm020289q | ||
| CHEMBL29652 | 108079 | 0 | None | -6456 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 562 | 9 | 1 | 7 | 6.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC2CCCCC2)c1C | 10.1021/jm020289q | ||
| 51003354 | 64841 | 0 | None | -74 | 2 | Mouse | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 920 | 24 | 1 | 17 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CN(C)S(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 | 10.1021/jm101110w | ||
| CHEMBL1672884 | 64841 | 0 | None | -74 | 2 | Mouse | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 920 | 24 | 1 | 17 | 4.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CN(C)S(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 | 10.1021/jm101110w | ||
| 9865409 | 109106 | 0 | None | -199 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 394 | 8 | 1 | 6 | 3.2 | COc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| CHEMBL303631 | 109106 | 0 | None | -199 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 394 | 8 | 1 | 6 | 3.2 | COc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| 10741834 | 50817 | 0 | None | -85 | 2 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 441 | 8 | 2 | 5 | 5.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC(C)C)c1C | 10.1021/jm970872k | ||
| CHEMBL151422 | 50817 | 0 | None | -85 | 2 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 441 | 8 | 2 | 5 | 5.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC(C)C)c1C | 10.1021/jm970872k | ||
| 44311873 | 211249 | 0 | None | 2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 636 | 13 | 2 | 7 | 5.0 | CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C1CCCCC1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL72358 | 211249 | 0 | None | 2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 636 | 13 | 2 | 7 | 5.0 | CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C1CCCCC1 | 10.1016/s0960-894x(98)00387-4 | ||
| 44311858 | 103378 | 0 | None | 2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 598 | 13 | 3 | 8 | 2.8 | CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)O | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL263301 | 103378 | 0 | None | 2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 598 | 13 | 3 | 8 | 2.8 | CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)O | 10.1016/s0960-894x(98)00387-4 | ||
| 10840560 | 11439 | 0 | None | -2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 558 | 13 | 1 | 8 | 5.2 | COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC | 10.1021/jm9910425 | ||
| CHEMBL103201 | 11439 | 0 | None | -2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 558 | 13 | 1 | 8 | 5.2 | COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC | 10.1021/jm9910425 | ||
| 44311989 | 211350 | 0 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 610 | 14 | 2 | 7 | 4.4 | CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)CC | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL73042 | 211350 | 0 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 610 | 14 | 2 | 7 | 4.4 | CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)CC | 10.1016/s0960-894x(98)00387-4 | ||
| 44274960 | 106339 | 0 | None | -12 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 450 | 10 | 1 | 6 | 4.9 | COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(C(C)C)cc2)c2ccccc2)n1 | 10.1021/jm030480f | ||
| CHEMBL283637 | 106339 | 0 | None | -12 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 450 | 10 | 1 | 6 | 4.9 | COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(C(C)C)cc2)c2ccccc2)n1 | 10.1021/jm030480f | ||
| 44307412 | 210437 | 0 | None | -12 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 466 | 10 | 0 | 8 | 4.5 | COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(C(C)C)cc1)c1ccccc1 | 10.1021/jm960274q | ||
| CHEMBL67325 | 210437 | 0 | None | -12 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 466 | 10 | 0 | 8 | 4.5 | COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(C(C)C)cc1)c1ccccc1 | 10.1021/jm960274q | ||
| 10621777 | 49848 | 0 | None | -12 | 2 | Rat | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 415 | 7 | 1 | 6 | 4.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1[N+](=O)[O-] | 10.1021/jm970872k | ||
| CHEMBL150481 | 49848 | 0 | None | -12 | 2 | Rat | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 415 | 7 | 1 | 6 | 4.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1[N+](=O)[O-] | 10.1021/jm970872k | ||
| 10548904 | 126288 | 0 | None | -380 | 2 | Rat | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CCC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL345551 | 126288 | 0 | None | -380 | 2 | Rat | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CCC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 44213540 | 46255 | 0 | None | -831 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 421 | 5 | 1 | 5 | 4.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccc[n+]3[O-])cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL147238 | 46255 | 0 | None | -831 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 421 | 5 | 1 | 5 | 4.1 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccc[n+]3[O-])cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| 11124821 | 106065 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 595 | 8 | 1 | 8 | 6.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)c2cc3ccccc3n2C)c1C | 10.1021/jm020289q | ||
| CHEMBL281977 | 106065 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 595 | 8 | 1 | 8 | 6.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)c2cc3ccccc3n2C)c1C | 10.1021/jm020289q | ||
| 10505357 | 116180 | 0 | None | -10 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 494 | 10 | 1 | 5 | 5.9 | Cc1ccc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| CHEMBL321984 | 116180 | 0 | None | -10 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 494 | 10 | 1 | 5 | 5.9 | Cc1ccc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| 10941084 | 108761 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 610 | 8 | 1 | 7 | 7.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)c2cc(Cl)cc(Cl)c2)c1C | 10.1021/jm020289q | ||
| CHEMBL30150 | 108761 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 610 | 8 | 1 | 7 | 7.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)c2cc(Cl)cc(Cl)c2)c1C | 10.1021/jm020289q | ||
| 443289 | 7498 | 47 | None | -831 | 3 | Rat | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970872k | ||||
| 997 | 7498 | 47 | None | -831 | 3 | Rat | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970872k | ||||
| CHEMBL314691 | 7498 | 47 | None | -831 | 3 | Rat | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970872k | ||||
| DB12054 | 7498 | 47 | None | -831 | 3 | Rat | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970872k | ||||
| 10119517 | 106010 | 0 | None | -169824 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 536 | 8 | 1 | 7 | 5.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(C)(C)C)c1C | 10.1021/jm020289q | ||
| CHEMBL281659 | 106010 | 0 | None | -169824 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 536 | 8 | 1 | 7 | 5.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(C)(C)C)c1C | 10.1021/jm020289q | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm970101g | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm970101g | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm970101g | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm970101g | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm970101g | ||
| 10669224 | 115243 | 0 | None | -1778 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cc3ncco3)cc2)c1C | 10.1021/jm000105c | ||
| CHEMBL319924 | 115243 | 0 | None | -1778 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cc3ncco3)cc2)c1C | 10.1021/jm000105c | ||
| 44265871 | 173697 | 0 | None | -53 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 547 | 10 | 2 | 8 | 4.6 | COc1ccccc1Cc1c(CCCO)nc(-c2ncccn2)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 | 10.1021/jm9505369 | ||
| CHEMBL428661 | 173697 | 0 | None | -53 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 547 | 10 | 2 | 8 | 4.6 | COc1ccccc1Cc1c(CCCO)nc(-c2ncccn2)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 | 10.1021/jm9505369 | ||
| 10692125 | 209842 | 0 | None | -26 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 396 | 8 | 2 | 7 | 2.3 | COc1cc(OC)nc(OC(C(=O)O)C(O)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| CHEMBL63648 | 209842 | 0 | None | -26 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 396 | 8 | 2 | 7 | 2.3 | COc1cc(OC)nc(OC(C(=O)O)C(O)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| 9848710 | 175859 | 4 | None | -1 | 4 | Pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 497 | 9 | 3 | 3 | 4.3 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL439759 | 175859 | 4 | None | -1 | 4 | Pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 497 | 9 | 3 | 3 | 4.3 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/0960-894X(96)00421-0 | ||
| 9848710 | 175859 | 4 | None | 1 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 497 | 9 | 3 | 3 | 4.3 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL439759 | 175859 | 4 | None | 1 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 497 | 9 | 3 | 3 | 4.3 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 11082049 | 106336 | 0 | None | -933 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 534 | 7 | 1 | 7 | 5.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCCC(C)(C)C2=O)c1C | 10.1021/jm020289q | ||
| CHEMBL283610 | 106336 | 0 | None | -933 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 534 | 7 | 1 | 7 | 5.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCCC(C)(C)C2=O)c1C | 10.1021/jm020289q | ||
| 51003353 | 64840 | 0 | None | -10 | 2 | Mouse | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 886 | 26 | 1 | 17 | 5.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CCCCOc4cccnc4F)nn3)c2)cc1 | 10.1021/jm101110w | ||
| CHEMBL1672883 | 64840 | 0 | None | -10 | 2 | Mouse | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 886 | 26 | 1 | 17 | 5.5 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CCCCOc4cccnc4F)nn3)c2)cc1 | 10.1021/jm101110w | ||
| 10599293 | 45799 | 0 | None | -128 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 441 | 9 | 2 | 5 | 5.8 | CCCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| CHEMBL146845 | 45799 | 0 | None | -128 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 441 | 9 | 2 | 5 | 5.8 | CCCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| 9953358 | 101575 | 13 | None | -102 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| CHEMBL25344 | 101575 | 13 | None | -102 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm960274q | ||
| 177236 | 8107 | 45 | None | -134 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 3508 | 8107 | 45 | None | -134 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | ||
| CHEMBL23261 | 8107 | 45 | None | -134 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | ||
| DB04883 | 8107 | 45 | None | -134 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.9 | COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2016.06.014 | ||
| 11082168 | 105991 | 0 | None | -7585 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 548 | 8 | 1 | 7 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(F)(F)F)c1C | 10.1021/jm020289q | ||
| CHEMBL281549 | 105991 | 0 | None | -7585 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 548 | 8 | 1 | 7 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(F)(F)F)c1C | 10.1021/jm020289q | ||
| 10839202 | 126014 | 0 | None | -6 | 2 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 503 | 8 | 2 | 5 | 6.2 | Cc1noc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL343477 | 126014 | 0 | None | -6 | 2 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 503 | 8 | 2 | 5 | 6.2 | Cc1noc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 22103537 | 48846 | 0 | None | -144 | 2 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccno3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL149592 | 48846 | 0 | None | -144 | 2 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccno3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| 44311698 | 210889 | 0 | None | 524 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 574 | 10 | 3 | 4 | 5.3 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccccn3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| CHEMBL70310 | 210889 | 0 | None | 524 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 574 | 10 | 3 | 4 | 5.3 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccccn3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 | 10.1016/s0960-894x(98)00387-4 | ||
| 9893800 | 114007 | 12 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 528 | 12 | 1 | 7 | 5.1 | COc1ccc(CCOC(c2ccccc2)(c2ccccc2)[C@H](Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/acs.jmedchem.5b01781 | ||
| CHEMBL316735 | 114007 | 12 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 528 | 12 | 1 | 7 | 5.1 | COc1ccc(CCOC(c2ccccc2)(c2ccccc2)[C@H](Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/acs.jmedchem.5b01781 | ||
| 9893800 | 114007 | 12 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 528 | 12 | 1 | 7 | 5.1 | COc1ccc(CCOC(c2ccccc2)(c2ccccc2)[C@H](Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| CHEMBL316735 | 114007 | 12 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 528 | 12 | 1 | 7 | 5.1 | COc1ccc(CCOC(c2ccccc2)(c2ccccc2)[C@H](Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| 10769887 | 114269 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 600 | 15 | 1 | 8 | 6.0 | CCc1ccc(C(OCCc2ccc(OC)c(OC)c2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| CHEMBL318535 | 114269 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 600 | 15 | 1 | 8 | 6.0 | CCc1ccc(C(OCCc2ccc(OC)c(OC)c2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| 10528341 | 21349 | 0 | None | -95 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 458 | 9 | 2 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2cccc(OCC(=O)O)c2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL1204523 | 21349 | 0 | None | -95 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 458 | 9 | 2 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2cccc(OCC(=O)O)c2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL149152 | 21349 | 0 | None | -95 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 458 | 9 | 2 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2cccc(OCC(=O)O)c2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 10972867 | 106479 | 0 | None | -19952 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 480 | 7 | 1 | 7 | 4.4 | CC(=O)N(C)Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm020289q | ||
| CHEMBL284656 | 106479 | 0 | None | -19952 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 480 | 7 | 1 | 7 | 4.4 | CC(=O)N(C)Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm020289q | ||
| 9852318 | 16386 | 8 | None | -2691 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| CHEMBL112624 | 16386 | 8 | None | -2691 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| CHEMBL1627022 | 16386 | 8 | None | -2691 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 613 | 11 | 2 | 9 | 4.5 | Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 | 10.1021/jm000538f | ||
| 10715881 | 128319 | 0 | None | -37 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 398 | 5 | 1 | 4 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL358545 | 128319 | 0 | None | -37 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 398 | 5 | 1 | 4 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 51003306 | 64837 | 0 | None | -295 | 2 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 670 | 19 | 1 | 12 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCF)c2)cc1 | 10.1021/jm101110w | ||
| CHEMBL1672880 | 64837 | 0 | None | -295 | 2 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 670 | 19 | 1 | 12 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCF)c2)cc1 | 10.1021/jm101110w | ||
| 10718053 | 50887 | 0 | None | -5 | 2 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 442 | 8 | 1 | 6 | 4.8 | CCOC(=O)c1c(C)noc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 | 10.1021/jm970872k | ||
| CHEMBL151525 | 50887 | 0 | None | -5 | 2 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 442 | 8 | 1 | 6 | 4.8 | CCOC(=O)c1c(C)noc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 | 10.1021/jm970872k | ||
| 11123603 | 108573 | 0 | None | -14125 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 475 | 7 | 1 | 8 | 4.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccnc2)c1C | 10.1021/jm020289q | ||
| CHEMBL30009 | 108573 | 0 | None | -14125 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 475 | 7 | 1 | 8 | 4.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccnc2)c1C | 10.1021/jm020289q | ||
| 11754273 | 107750 | 0 | None | -21877 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 466 | 7 | 2 | 7 | 4.1 | CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm000105c | ||
| CHEMBL29422 | 107750 | 0 | None | -21877 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 466 | 7 | 2 | 7 | 4.1 | CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm000105c | ||
| 11754273 | 107750 | 0 | None | -21877 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 466 | 7 | 2 | 7 | 4.1 | CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm020289q | ||
| CHEMBL29422 | 107750 | 0 | None | -21877 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 466 | 7 | 2 | 7 | 4.1 | CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm020289q | ||
| 11795351 | 49623 | 0 | None | -109 | 2 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 401 | 6 | 1 | 4 | 4.8 | CC(C)Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc(Cl)nn2)cc1 | 10.1021/jm970872k | ||
| CHEMBL150273 | 49623 | 0 | None | -109 | 2 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 401 | 6 | 1 | 4 | 4.8 | CC(C)Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc(Cl)nn2)cc1 | 10.1021/jm970872k | ||
| 11103112 | 106644 | 0 | None | -4570 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 501 | 8 | 1 | 7 | 6.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COc2ccccc2)c1C | 10.1021/jm020289q | ||
| CHEMBL28586 | 106644 | 0 | None | -4570 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 501 | 8 | 1 | 7 | 6.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COc2ccccc2)c1C | 10.1021/jm020289q | ||
| 44274885 | 100861 | 0 | None | -29 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 454 | 10 | 1 | 7 | 4.5 | COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(SC)cc2)c2ccccc2)n1 | 10.1021/jm030480f | ||
| CHEMBL24906 | 100861 | 0 | None | -29 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 454 | 10 | 1 | 7 | 4.5 | COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(SC)cc2)c2ccccc2)n1 | 10.1021/jm030480f | ||
| 44307287 | 210537 | 0 | None | -29 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 470 | 10 | 0 | 9 | 4.1 | COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(SC)cc1)c1ccccc1 | 10.1021/jm960274q | ||
| CHEMBL67957 | 210537 | 0 | None | -29 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 470 | 10 | 0 | 9 | 4.1 | COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(SC)cc1)c1ccccc1 | 10.1021/jm960274q | ||
| 11059912 | 106116 | 0 | None | -23988 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 481 | 9 | 1 | 7 | 5.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COCC(C)C)c1C | 10.1021/jm020289q | ||
| CHEMBL282303 | 106116 | 0 | None | -23988 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 481 | 9 | 1 | 7 | 5.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COCC(C)C)c1C | 10.1021/jm020289q | ||
| 19085508 | 46360 | 0 | None | -218 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 466 | 7 | 1 | 8 | 4.2 | COc1cc(OC)nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL147365 | 46360 | 0 | None | -218 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 466 | 7 | 1 | 8 | 4.2 | COc1cc(OC)nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 | 10.1016/s0960-894x(01)00791-0 | ||
| 10453858 | 166881 | 0 | None | -31 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 404 | 4 | 2 | 5 | 4.1 | COc1ccc([C@@H]2c3cc(O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1021/jm00037a003 | ||
| CHEMBL41087 | 166881 | 0 | None | -31 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 404 | 4 | 2 | 5 | 4.1 | COc1ccc([C@@H]2c3cc(O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 | 10.1021/jm00037a003 | ||
| 9955561 | 109630 | 0 | None | - | 1 | Pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 453 | 8 | 2 | 2 | 4.8 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)NCCc2c[nH]c3ccccc23)c1 | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL305615 | 109630 | 0 | None | - | 1 | Pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 453 | 8 | 2 | 2 | 4.8 | Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)NCCc2c[nH]c3ccccc23)c1 | 10.1016/0960-894X(96)00421-0 | ||
| 44314882 | 163955 | 0 | None | 380 | 2 | Pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1562 | 47 | 19 | 18 | 0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 77282212 | 163955 | 0 | None | 380 | 2 | Pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1562 | 47 | 19 | 18 | 0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL407559 | 163955 | 0 | None | 380 | 2 | Pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1562 | 47 | 19 | 18 | 0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 9894460 | 213488 | 9 | None | -41 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm9505369 | ||
| CHEMBL313871 | 213488 | 9 | None | -41 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm9505369 | ||
| CHEMBL8978 | 213488 | 9 | None | -41 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 539 | 10 | 2 | 7 | 4.8 | CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm9505369 | ||
| 44314883 | 162540 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1520 | 45 | 19 | 18 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 77282211 | 162540 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1520 | 45 | 19 | 18 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL405796 | 162540 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1520 | 45 | 19 | 18 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC | 10.1016/0960-894X(96)00421-0 | ||
| 10526510 | 127846 | 0 | None | -12 | 2 | Rat | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 427 | 8 | 1 | 6 | 4.2 | COc1cc(OC)nc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)n1 | 10.1021/jm970872k | ||
| CHEMBL356972 | 127846 | 0 | None | -12 | 2 | Rat | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 427 | 8 | 1 | 6 | 4.2 | COc1cc(OC)nc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)n1 | 10.1021/jm970872k | ||
| 44314819 | 162536 | 0 | None | - | 1 | Pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1520 | 45 | 19 | 18 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(96)00421-0 | ||
| 77282207 | 162536 | 0 | None | - | 1 | Pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1520 | 45 | 19 | 18 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(96)00421-0 | ||
| CHEMBL405753 | 162536 | 0 | None | - | 1 | Pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1520 | 45 | 19 | 18 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/0960-894X(96)00421-0 | ||
| 22103743 | 49610 | 0 | None | -9332 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 411 | 5 | 1 | 6 | 4.9 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nccs3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL150260 | 49610 | 0 | None | -9332 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 411 | 5 | 1 | 6 | 4.9 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nccs3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| 51003352 | 64839 | 0 | None | -1230 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1020 | 35 | 1 | 21 | 4.7 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCOCc3cn(CCOCCOCCOCCOc4cccnc4F)nn3)c2)cc1 | 10.1021/jm101110w | ||
| CHEMBL1672882 | 64839 | 0 | None | -1230 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1020 | 35 | 1 | 21 | 4.7 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCOCc3cn(CCOCCOCCOCCOc4cccnc4F)nn3)c2)cc1 | 10.1021/jm101110w | ||
| 10647471 | 49099 | 0 | None | -125 | 2 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 456 | 7 | 3 | 5 | 4.7 | CNC(=O)Nc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| CHEMBL149818 | 49099 | 0 | None | -125 | 2 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 456 | 7 | 3 | 5 | 4.7 | CNC(=O)Nc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| 10597897 | 47949 | 0 | None | -724 | 2 | Rat | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 5.0 | COc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| CHEMBL148853 | 47949 | 0 | None | -724 | 2 | Rat | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 5.0 | COc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C | 10.1021/jm970872k | ||
| 10624645 | 11105 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 482 | 10 | 1 | 5 | 5.4 | Cc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| CHEMBL100954 | 11105 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 482 | 10 | 1 | 5 | 5.4 | Cc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| 10929533 | 107131 | 0 | None | -10964 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 5.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)C)C2CC2)c1C | 10.1021/jm020289q | ||
| CHEMBL28963 | 107131 | 0 | None | -10964 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 5.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)C)C2CC2)c1C | 10.1021/jm020289q | ||
| 10432263 | 108929 | 0 | None | -85 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 420 | 8 | 1 | 6 | 3.4 | COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCC2 | 10.1021/jm960274q | ||
| CHEMBL302564 | 108929 | 0 | None | -85 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 420 | 8 | 1 | 6 | 3.4 | COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCC2 | 10.1021/jm960274q | ||
| 10643748 | 128215 | 0 | None | -29 | 2 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(CC(C)C)c2)c1C | 10.1021/jm970872k | ||
| CHEMBL358226 | 128215 | 0 | None | -29 | 2 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(CC(C)C)c2)c1C | 10.1021/jm970872k | ||
| 9979632 | 109678 | 0 | None | -41 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 422 | 8 | 1 | 7 | 2.8 | COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCO2 | 10.1021/jm960274q | ||
| CHEMBL305980 | 109678 | 0 | None | -41 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 422 | 8 | 1 | 7 | 2.8 | COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCO2 | 10.1021/jm960274q | ||
| 10501299 | 126632 | 0 | None | -147 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 402 | 6 | 1 | 5 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(SC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL348685 | 126632 | 0 | None | -147 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 402 | 6 | 1 | 5 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(SC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 11813553 | 106122 | 0 | None | -14454 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 542 | 8 | 1 | 7 | 5.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)c2ccccc2)c1C | 10.1021/jm020289q | ||
| CHEMBL282359 | 106122 | 0 | None | -14454 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 542 | 8 | 1 | 7 | 5.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)c2ccccc2)c1C | 10.1021/jm020289q | ||
| 10815239 | 115335 | 0 | None | -125 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 500 | 10 | 1 | 7 | 5.0 | COc1ccc(OC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| CHEMBL320224 | 115335 | 0 | None | -125 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 500 | 10 | 1 | 7 | 5.0 | COc1ccc(OC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| 10690608 | 127837 | 0 | None | -112 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 371 | 5 | 1 | 5 | 3.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL356901 | 127837 | 0 | None | -112 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 371 | 5 | 1 | 5 | 3.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 19934534 | 113472 | 0 | None | 5 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 468 | 6 | 3 | 4 | 5.0 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3cc4ccccc4[nH]3)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| CHEMBL314364 | 113472 | 0 | None | 5 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 468 | 6 | 3 | 4 | 5.0 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3cc4ccccc4[nH]3)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| 10837085 | 109086 | 0 | None | -39 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 446 | 9 | 1 | 7 | 3.2 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2F)c2ccccc2F)n1 | 10.1021/jm960274q | ||
| CHEMBL303501 | 109086 | 0 | None | -39 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 446 | 9 | 1 | 7 | 3.2 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2F)c2ccccc2F)n1 | 10.1021/jm960274q | ||
| 19934546 | 212993 | 0 | None | -8 | 2 | Rat | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 466 | 7 | 1 | 4 | 6.0 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(OCc3cccc4ccccc34)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| CHEMBL86581 | 212993 | 0 | None | -8 | 2 | Rat | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 466 | 7 | 1 | 4 | 6.0 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(OCc3cccc4ccccc34)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| 10693130 | 128747 | 0 | None | -16 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 5.0 | COc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 | 10.1021/jm970872k | ||
| CHEMBL359152 | 128747 | 0 | None | -16 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 5.0 | COc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 | 10.1021/jm970872k | ||
| 11799973 | 11204 | 0 | None | -31 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 514 | 11 | 1 | 7 | 5.1 | COc1ccc(COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| CHEMBL101587 | 11204 | 0 | None | -31 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 514 | 11 | 1 | 7 | 5.1 | COc1ccc(COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| 18660521 | 48471 | 0 | None | -2754 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 4.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccn3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL149232 | 48471 | 0 | None | -2754 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 4.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccn3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| 11731054 | 105587 | 0 | None | -21379 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 522 | 7 | 1 | 7 | 5.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)(C)C)c1C | 10.1021/jm020289q | ||
| CHEMBL27855 | 105587 | 0 | None | -21379 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 522 | 7 | 1 | 7 | 5.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)(C)C)c1C | 10.1021/jm020289q | ||
| 51002602 | 64843 | 0 | None | -812 | 2 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 751 | 21 | 1 | 15 | 4.0 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CF)nn3)c2)cc1 | 10.1021/jm101110w | ||
| CHEMBL1672886 | 64843 | 0 | None | -812 | 2 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 751 | 21 | 1 | 15 | 4.0 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CF)nn3)c2)cc1 | 10.1021/jm101110w | ||
| 9864017 | 48102 | 0 | None | -194 | 2 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 367 | 4 | 2 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2cc3ccccc3[nH]2)c1C | 10.1021/jm970872k | ||
| CHEMBL148967 | 48102 | 0 | None | -194 | 2 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 367 | 4 | 2 | 4 | 4.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2cc3ccccc3[nH]2)c1C | 10.1021/jm970872k | ||
| 10741144 | 126547 | 0 | None | -407 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 4.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC=O)c1C | 10.1021/jm970872k | ||
| CHEMBL347982 | 126547 | 0 | None | -407 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 4.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC=O)c1C | 10.1021/jm970872k | ||
| 6433100 | 11321 | 7 | None | -2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 528 | 12 | 1 | 7 | 5.1 | COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| CHEMBL102405 | 11321 | 7 | None | -2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 528 | 12 | 1 | 7 | 5.1 | COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC | 10.1021/jm9910425 | ||
| 443289 | 7498 | 47 | None | -831 | 3 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00019-P | ||||
| 997 | 7498 | 47 | None | -831 | 3 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00019-P | ||||
| CHEMBL314691 | 7498 | 47 | None | -831 | 3 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00019-P | ||||
| DB12054 | 7498 | 47 | None | -831 | 3 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00019-P | ||||
| 19934544 | 212979 | 0 | None | 2 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 482 | 7 | 3 | 4 | 4.9 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)Cc3c[nH]c4ccccc34)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| CHEMBL86489 | 212979 | 0 | None | 2 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 482 | 7 | 3 | 4 | 4.9 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)Cc3c[nH]c4ccccc34)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| 44333366 | 114203 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 570 | 12 | 1 | 8 | 5.2 | COc1ccc(CCOC(c2ccc(C)cc2)(c2ccc(C)cc2)C(Oc2nc3c(c(OC)n2)COC3)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| CHEMBL318146 | 114203 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 570 | 12 | 1 | 8 | 5.2 | COc1ccc(CCOC(c2ccc(C)cc2)(c2ccc(C)cc2)C(Oc2nc3c(c(OC)n2)COC3)C(=O)O)cc1 | 10.1021/jm9910425 | ||
| 46228116 | 208001 | 0 | None | -2 | 2 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 598 | 10 | 1 | 9 | 4.6 | COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCBr)cc2)cc(OC)c1OC | 10.1016/j.bmc.2009.08.058 | ||
| CHEMBL603635 | 208001 | 0 | None | -2 | 2 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 598 | 10 | 1 | 9 | 4.6 | COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCBr)cc2)cc(OC)c1OC | 10.1016/j.bmc.2009.08.058 | ||
| 11733544 | 106011 | 0 | None | -7244 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 480 | 7 | 1 | 7 | 4.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)N(C)C)c1C | 10.1021/jm020289q | ||
| CHEMBL281668 | 106011 | 0 | None | -7244 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 480 | 7 | 1 | 7 | 4.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)N(C)C)c1C | 10.1021/jm020289q | ||
| 10503999 | 48088 | 0 | None | -6 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 456 | 8 | 3 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccc(NC(=O)CN)cc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL148953 | 48088 | 0 | None | -6 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 456 | 8 | 3 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccc(NC(=O)CN)cc2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 22103385 | 127863 | 0 | None | -19054 | 2 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 396 | 5 | 1 | 7 | 3.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nnco3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL357077 | 127863 | 0 | None | -19054 | 2 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 396 | 5 | 1 | 7 | 3.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nnco3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| 10045790 | 148430 | 0 | None | -17 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 388 | 4 | 1 | 4 | 4.4 | COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc4c(c3)OCO4)[C@@H]2C(=O)O)cc1 | 10.1021/jm00037a003 | ||
| CHEMBL38537 | 148430 | 0 | None | -17 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 388 | 4 | 1 | 4 | 4.4 | COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc4c(c3)OCO4)[C@@H]2C(=O)O)cc1 | 10.1021/jm00037a003 | ||
| 9958321 | 85926 | 0 | None | -19498 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 520 | 7 | 1 | 7 | 5.2 | Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCC(C)(C)C2=O)c1C | 10.1021/jm020289q | ||
| CHEMBL2113316 | 85926 | 0 | None | -19498 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 520 | 7 | 1 | 7 | 5.2 | Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCC(C)(C)C2=O)c1C | 10.1021/jm020289q | ||
| 10548722 | 12252 | 0 | None | -20892 | 2 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnco3)cc2)c1C | 10.1021/jm000105c | ||
| CHEMBL107574 | 12252 | 0 | None | -20892 | 2 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 395 | 5 | 1 | 6 | 4.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnco3)cc2)c1C | 10.1021/jm000105c | ||
| 11027595 | 107017 | 0 | None | -19952 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 508 | 8 | 1 | 7 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)C)c1C | 10.1021/jm020289q | ||
| CHEMBL28863 | 107017 | 0 | None | -19952 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 508 | 8 | 1 | 7 | 5.0 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)C)c1C | 10.1021/jm020289q | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm020289q | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm020289q | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm020289q | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm020289q | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 10.1021/jm020289q | ||
| 15297287 | 171191 | 0 | None | 3 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 424 | 5 | 2 | 4 | 5.2 | O=C(O)CN1C(=O)c2ccccc2Nc2ccc(OCc3cccc4ccccc34)cc21 | 10.1016/0960-894X(95)00019-P | ||
| CHEMBL421349 | 171191 | 0 | None | 3 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 424 | 5 | 2 | 4 | 5.2 | O=C(O)CN1C(=O)c2ccccc2Nc2ccc(OCc3cccc4ccccc34)cc21 | 10.1016/0960-894X(95)00019-P | ||
| 44277840 | 105030 | 0 | None | -81283 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 522 | 7 | 1 | 7 | 5.8 | Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2N(C)C(=O)CC(C)(C)C)c1C | 10.1021/jm020289q | ||
| CHEMBL274489 | 105030 | 0 | None | -81283 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 522 | 7 | 1 | 7 | 5.8 | Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2N(C)C(=O)CC(C)(C)C)c1C | 10.1021/jm020289q | ||
| 10836583 | 46467 | 0 | None | -43 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 434 | 7 | 1 | 5 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCc3ccccc3)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL147521 | 46467 | 0 | None | -43 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 434 | 7 | 1 | 5 | 5.3 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCc3ccccc3)cc2)c1C | 10.1021/jm970872k | ||
| 51003307 | 64838 | 0 | None | -3548 | 2 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 751 | 21 | 1 | 15 | 4.0 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCc3cn(CCOCCOCCOCCF)nn3)c2)cc1 | 10.1021/jm101110w | ||
| CHEMBL1672881 | 64838 | 0 | None | -3548 | 2 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 751 | 21 | 1 | 15 | 4.0 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCc3cn(CCOCCOCCOCCF)nn3)c2)cc1 | 10.1021/jm101110w | ||
| 11071765 | 175986 | 0 | None | -8709 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 556 | 9 | 1 | 7 | 5.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccc2)c1C | 10.1021/jm020289q | ||
| CHEMBL440780 | 175986 | 0 | None | -8709 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 556 | 9 | 1 | 7 | 5.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccc2)c1C | 10.1021/jm020289q | ||
| 51002601 | 64842 | 0 | None | -123 | 2 | Mouse | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 906 | 24 | 2 | 17 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CNS(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 | 10.1021/jm101110w | ||
| CHEMBL1672885 | 64842 | 0 | None | -123 | 2 | Mouse | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 906 | 24 | 2 | 17 | 4.2 | COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CNS(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 | 10.1021/jm101110w | ||
| 9934204 | 113722 | 0 | None | 1 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 465 | 7 | 2 | 4 | 6.0 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NCc3cccc4ccccc34)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| CHEMBL314915 | 113722 | 0 | None | 1 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 465 | 7 | 2 | 4 | 6.0 | CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NCc3cccc4ccccc34)ccc21 | 10.1016/0960-894X(95)00019-P | ||
| 11049336 | 106716 | 0 | None | -3630 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 497 | 7 | 1 | 6 | 6.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C/c2ccccc2)c1C | 10.1021/jm020289q | ||
| CHEMBL286279 | 106716 | 0 | None | -3630 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 497 | 7 | 1 | 6 | 6.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C/c2ccccc2)c1C | 10.1021/jm020289q | ||
| 10673091 | 170104 | 0 | None | -4 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 502 | 10 | 1 | 5 | 5.8 | Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(Cl)cc2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm9910425 | ||
| CHEMBL418992 | 170104 | 0 | None | -4 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 502 | 10 | 1 | 5 | 5.8 | Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(Cl)cc2)(c2ccccc2)c2ccccc2)n1 | 10.1021/jm9910425 | ||
| 10621010 | 171641 | 0 | None | -186 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 400 | 6 | 2 | 5 | 4.7 | Cc1noc(NS(=O)(=O)c2cccc(O)c2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| CHEMBL421955 | 171641 | 0 | None | -186 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 400 | 6 | 2 | 5 | 4.7 | Cc1noc(NS(=O)(=O)c2cccc(O)c2-c2ccc(CC(C)C)cc2)c1C | 10.1021/jm970872k | ||
| 22103787 | 47766 | 0 | None | -1380 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-n3cccn3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| CHEMBL148719 | 47766 | 0 | None | -1380 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 3.9 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-n3cccn3)cc2)c1C | 10.1016/s0960-894x(01)00791-0 | ||
| 10811477 | 11590 | 0 | None | -19952 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncoc3C)cc2)c1C | 10.1021/jm000105c | ||
| CHEMBL104172 | 11590 | 0 | None | -19952 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncoc3C)cc2)c1C | 10.1021/jm000105c | ||
| 10813228 | 114437 | 0 | None | -46 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 5.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nc4ccccc4o3)cc2)c1C | 10.1021/jm000105c | ||
| CHEMBL319036 | 114437 | 0 | None | -46 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 5.6 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nc4ccccc4o3)cc2)c1C | 10.1021/jm000105c | ||
| 10918368 | 109300 | 0 | None | -21379 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 520 | 7 | 1 | 7 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CC(C)(C)CC2=O)c1C | 10.1021/jm020289q | ||
| CHEMBL30405 | 109300 | 0 | None | -21379 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 520 | 7 | 1 | 7 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CC(C)(C)CC2=O)c1C | 10.1021/jm020289q | ||
| 46228118 | 209321 | 0 | None | -263 | 2 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 690 | 13 | 1 | 12 | 4.7 | COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCOc3ccc(S(C)(=O)=O)cc3)cc2)cc(OC)c1OC | 10.1016/j.bmc.2009.08.058 | ||
| CHEMBL611626 | 209321 | 0 | None | -263 | 2 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 690 | 13 | 1 | 12 | 4.7 | COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCOc3ccc(S(C)(=O)=O)cc3)cc2)cc(OC)c1OC | 10.1016/j.bmc.2009.08.058 | ||
| 10573784 | 172116 | 0 | None | -95 | 2 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 413 | 7 | 2 | 5 | 4.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CN)c1C | 10.1021/jm970872k | ||
| CHEMBL423583 | 172116 | 0 | None | -95 | 2 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 413 | 7 | 2 | 5 | 4.4 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CN)c1C | 10.1021/jm970872k | ||
| 10671031 | 109471 | 0 | None | -29 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 446 | 9 | 1 | 7 | 3.2 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(F)cc2)c2ccc(F)cc2)n1 | 10.1021/jm960274q | ||
| CHEMBL304721 | 109471 | 0 | None | -29 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 446 | 9 | 1 | 7 | 3.2 | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(F)cc2)c2ccc(F)cc2)n1 | 10.1021/jm960274q | ||
| 45257115 | 208111 | 0 | None | -39 | 2 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 538 | 10 | 1 | 9 | 4.2 | COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCF)cc2)cc(OC)c1OC | 10.1016/j.bmc.2009.08.058 | ||
| CHEMBL604286 | 208111 | 0 | None | -39 | 2 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 538 | 10 | 1 | 9 | 4.2 | COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCF)cc2)cc(OC)c1OC | 10.1016/j.bmc.2009.08.058 | ||
| 10973161 | 107821 | 0 | None | -6456 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 502 | 8 | 2 | 9 | 4.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNc2ccncn2)c1C | 10.1021/jm020289q | ||
| CHEMBL29464 | 107821 | 0 | None | -6456 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 502 | 8 | 2 | 9 | 4.8 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNc2ccncn2)c1C | 10.1021/jm020289q | ||
| 10741830 | 49617 | 0 | None | -3 | 2 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.9 | CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 | 10.1021/jm970872k | ||
| CHEMBL150269 | 49617 | 0 | None | -3 | 2 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.9 | CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 | 10.1021/jm970872k | ||
| 10668703 | 171962 | 0 | None | -1230 | 2 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 400 | 6 | 2 | 5 | 4.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2O)c1C | 10.1021/jm970872k | ||
| CHEMBL422851 | 171962 | 0 | None | -1230 | 2 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 400 | 6 | 2 | 5 | 4.7 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2O)c1C | 10.1021/jm970872k | ||
| 5344 | 180252 | 101 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 267 | 3 | 2 | 5 | 1.7 | Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C | None | ||
| CHEMBL453 | 180252 | 101 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 267 | 3 | 2 | 5 | 1.7 | Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C | None | ||
| 6662 | 224518 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 309 | 3 | 1 | 6 | 1.6 | CC(=O)N(C1=C(C)C(C)=NO1)S(=O)(=O)C1=CC=C(N)C=C1 | None | ||
| 11477084 | 10382 | 53 | None | - | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | None | ||
| 216235 | 10382 | 53 | None | - | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | None | ||
| 3548 | 10382 | 53 | None | - | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | None | ||
| 3950 | 10382 | 53 | None | - | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | None | ||
| CHEMBL282724 | 10382 | 53 | None | - | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | None | ||
| DB06268 | 10382 | 53 | None | - | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 454 | 6 | 1 | 8 | 4.0 | O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C | None | ||
| 16004692 | 9232 | 91 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | None | ||
| 4809 | 9232 | 91 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | None | ||
| 7352 | 9232 | 91 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | None | ||
| CHEMBL2103873 | 9232 | 91 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | None | ||
| DB08932 | 9232 | 91 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 586 | 11 | 2 | 8 | 3.6 | CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br | None | ||
| 1007 | 10413 | 0 | None | -3 | 2 | Human | 10.0 | pKd | = | 10 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 16130933 | 10413 | 0 | None | -3 | 2 | Human | 10.0 | pKd | = | 10 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 16133819 | 10413 | 0 | None | -3 | 2 | Human | 10.0 | pKd | = | 10 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 3886 | 10413 | 0 | None | -3 | 2 | Human | 10.0 | pKd | = | 10 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 44210030 | 10413 | 0 | None | -3 | 2 | Human | 10.0 | pKd | = | 10 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 56947141 | 10413 | 0 | None | -3 | 2 | Human | 10.0 | pKd | = | 10 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| CHEMBL3188091 | 10413 | 0 | None | -3 | 2 | Human | 10.0 | pKd | = | 10 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| DB06138 | 10413 | 0 | None | -3 | 2 | Human | 10.0 | pKd | = | 10 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 3887 | 8853 | 45 | None | -7 | 4 | Human | 7.2 | pKd | = | 7.2 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| 5311192 | 8853 | 45 | None | -7 | 4 | Human | 7.2 | pKd | = | 7.2 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| CHEMBL72410 | 8853 | 45 | None | -7 | 4 | Human | 7.2 | pKd | = | 7.2 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| 1010 | 7500 | 0 | None | 2 | 2 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | 641 | 11 | 3 | 8 | 4.9 | CCCC[C@@H](N(C(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@H](C)CCC[C@@H]1C)C(=O)[C@@H](Cc1cn(c2c1cccc2)C(=O)OC)N)C(=O)O | 8904635 | ||
| 3081333 | 7500 | 0 | None | 2 | 2 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | 641 | 11 | 3 | 8 | 4.9 | CCCC[C@@H](N(C(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@H](C)CCC[C@@H]1C)C(=O)[C@@H](Cc1cn(c2c1cccc2)C(=O)OC)N)C(=O)O | 8904635 | ||
| 1009 | 6982 | 25 | None | - | 1 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10479298 | ||
| 5310991 | 6982 | 25 | None | - | 1 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10479298 | ||
| CHEMBL332794 | 6982 | 25 | None | - | 1 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | 558 | 11 | 2 | 6 | 5.8 | CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 | 10479298 | ||
| 3837 | 7122 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9.0 | Binding | Guide to Pharmacology | None | None | None | None | 1472961 | ||||
| 1008 | 10246 | 0 | None | -15 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 8587419 | ||||
| 1008 | 10246 | 0 | None | -15 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| 16132429 | 10246 | 0 | None | -15 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 8587419 | ||||
| 16132429 | 10246 | 0 | None | -15 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| CHEMBL1790178 | 10246 | 0 | None | -15 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 8587419 | ||||
| CHEMBL1790178 | 10246 | 0 | None | -15 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| 1007 | 10413 | 0 | None | 3 | 2 | Rat | 10.0 | pKd | = | 10.0 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 16130933 | 10413 | 0 | None | 3 | 2 | Rat | 10.0 | pKd | = | 10.0 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 16133819 | 10413 | 0 | None | 3 | 2 | Rat | 10.0 | pKd | = | 10.0 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 3886 | 10413 | 0 | None | 3 | 2 | Rat | 10.0 | pKd | = | 10.0 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 44210030 | 10413 | 0 | None | 3 | 2 | Rat | 10.0 | pKd | = | 10.0 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 56947141 | 10413 | 0 | None | 3 | 2 | Rat | 10.0 | pKd | = | 10.0 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| CHEMBL3188091 | 10413 | 0 | None | 3 | 2 | Rat | 10.0 | pKd | = | 10.0 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| DB06138 | 10413 | 0 | None | 3 | 2 | Rat | 10.0 | pKd | = | 10.0 | Binding | Guide to Pharmacology | None | None | None | None | 8301559 | ||||
| 1004 | 8346 | 0 | None | -2 | 2 | Rat | 10.3 | pKd | None | 10.3 | Binding | Guide to Pharmacology | None | None | None | None | 1850245 | ||||
| 1004 | 8346 | 0 | None | -2 | 2 | Rat | 10.3 | pKd | None | 10.3 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| 16219334 | 8346 | 0 | None | -2 | 2 | Rat | 10.3 | pKd | None | 10.3 | Binding | Guide to Pharmacology | None | None | None | None | 1850245 | ||||
| 16219334 | 8346 | 0 | None | -2 | 2 | Rat | 10.3 | pKd | None | 10.3 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| 1008 | 10246 | 0 | None | 15 | 2 | Rat | 10.5 | pKd | None | 10.5 | Binding | Guide to Pharmacology | None | None | None | None | 1850245 | ||||
| 1008 | 10246 | 0 | None | 15 | 2 | Rat | 10.5 | pKd | None | 10.5 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| 16132429 | 10246 | 0 | None | 15 | 2 | Rat | 10.5 | pKd | None | 10.5 | Binding | Guide to Pharmacology | None | None | None | None | 1850245 | ||||
| 16132429 | 10246 | 0 | None | 15 | 2 | Rat | 10.5 | pKd | None | 10.5 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| CHEMBL1790178 | 10246 | 0 | None | 15 | 2 | Rat | 10.5 | pKd | None | 10.5 | Binding | Guide to Pharmacology | None | None | None | None | 1850245 | ||||
| CHEMBL1790178 | 10246 | 0 | None | 15 | 2 | Rat | 10.5 | pKd | None | 10.5 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| 1004 | 8346 | 0 | None | 2 | 2 | Human | 10.7 | pKd | None | 10.7 | Binding | Guide to Pharmacology | None | None | None | None | 7524189 | ||||
| 1004 | 8346 | 0 | None | 2 | 2 | Human | 10.7 | pKd | None | 10.7 | Binding | Guide to Pharmacology | None | None | None | None | 8460684 | ||||
| 1004 | 8346 | 0 | None | 2 | 2 | Human | 10.7 | pKd | None | 10.7 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| 16219334 | 8346 | 0 | None | 2 | 2 | Human | 10.7 | pKd | None | 10.7 | Binding | Guide to Pharmacology | None | None | None | None | 7524189 | ||||
| 16219334 | 8346 | 0 | None | 2 | 2 | Human | 10.7 | pKd | None | 10.7 | Binding | Guide to Pharmacology | None | None | None | None | 8460684 | ||||
| 16219334 | 8346 | 0 | None | 2 | 2 | Human | 10.7 | pKd | None | 10.7 | Binding | Guide to Pharmacology | None | None | None | None | 8904635 | ||||
| 1010 | 7500 | 0 | None | -2 | 2 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 641 | 11 | 3 | 8 | 4.9 | CCCC[C@@H](N(C(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@H](C)CCC[C@@H]1C)C(=O)[C@@H](Cc1cn(c2c1cccc2)C(=O)OC)N)C(=O)O | 8904635 | ||
| 3081333 | 7500 | 0 | None | -2 | 2 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 641 | 11 | 3 | 8 | 4.9 | CCCC[C@@H](N(C(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@H](C)CCC[C@@H]1C)C(=O)[C@@H](Cc1cn(c2c1cccc2)C(=O)OC)N)C(=O)O | 8904635 | ||
| 186002 | 109619 | 23 | 125I-ENDOTHELIN | -3 | 3 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 531 | 10 | 2 | 6 | 5.4 | CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1C[C@H](C)C(=O)O)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | None | ||
| CHEMBL305576 | 109619 | 23 | 125I-ENDOTHELIN | -3 | 3 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 531 | 10 | 2 | 6 | 5.4 | CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1C[C@H](C)C(=O)O)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 | None | ||
| 44208932 | 147485 | 7 | UNDEFINED | -89125 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
| CHEMBL381689 | 147485 | 7 | UNDEFINED | -89125 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
| 1973 | 210262 | 15 | 125I-ENDOTHELIN | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
| CHEMBL1394464 | 210262 | 15 | 125I-ENDOTHELIN | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
| CHEMBL66089 | 210262 | 15 | 125I-ENDOTHELIN | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
| None | 223272 | 0 | 125I-ENDOTHELIN | -10471285 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 372 | 2 | 1 | 3 | 4.4 | CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl | None | ||
| 104865 | 7493 | 99 | 125I-ENDOTHELIN | -6 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| 3494 | 7493 | 99 | 125I-ENDOTHELIN | -6 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| 392 | 7493 | 99 | 125I-ENDOTHELIN | -6 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| CHEMBL957 | 7493 | 99 | 125I-ENDOTHELIN | -6 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| DB00559 | 7493 | 99 | 125I-ENDOTHELIN | -6 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| 104865 | 7493 | 99 | 125I-ENDOTHELIN | -6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| 3494 | 7493 | 99 | 125I-ENDOTHELIN | -6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| 392 | 7493 | 99 | 125I-ENDOTHELIN | -6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| CHEMBL957 | 7493 | 99 | 125I-ENDOTHELIN | -6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| DB00559 | 7493 | 99 | 125I-ENDOTHELIN | -6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| None | 222855 | 0 | 125I-ENDOTHELIN | -52 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 520 | 10 | 2 | 7 | 4.7 | CCCOC1=CC2=C(C=C1)C(C(C2C3=C(C=C(C=C3)OC)OCC(=O)O)C(=O)O)C4=CC5=C(C=C4)OCO5 | None | ||
| 3951 | 7179 | 86 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | None | ||
| 4337 | 7179 | 86 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | None | ||
| 6918493 | 7179 | 86 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | None | ||
| CHEMBL1111 | 7179 | 86 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | None | ||
| DB06403 | 7179 | 86 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 378 | 7 | 1 | 5 | 3.5 | COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 | None | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | None | ||
| 12286 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | Guide to Pharmacology | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 9703472 | ||
| 6433095 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | Guide to Pharmacology | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 9703472 | ||
| CHEMBL109648 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | Guide to Pharmacology | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 9703472 | ||
| DB06677 | 7735 | 36 | None | -1348 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | Guide to Pharmacology | 577 | 11 | 3 | 13 | 2.4 | Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC | 9703472 | ||
| 159594 | 7310 | 45 | None | -4073 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 8676339 | ||
| 3487 | 7310 | 45 | None | -4073 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 8676339 | ||
| CHEMBL9194 | 7310 | 45 | None | -4073 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 8676339 | ||
| DB06199 | 7310 | 45 | None | -4073 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 510 | 12 | 1 | 6 | 4.7 | CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC | 8676339 | ||
| 13016 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | Guide to Pharmacology | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10956219 | ||
| 9843631 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | Guide to Pharmacology | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10956219 | ||
| CHEMBL24461 | 7457 | 13 | None | -13182 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | Guide to Pharmacology | 395 | 5 | 1 | 6 | 4.4 | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 | 10956219 | ||
| 104865 | 7493 | 99 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | ||
| 3494 | 7493 | 99 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | ||
| 392 | 7493 | 99 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | ||
| CHEMBL957 | 7493 | 99 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | ||
| DB00559 | 7493 | 99 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | Guide to Pharmacology | 551 | 10 | 2 | 10 | 4.2 | OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 | 8035319 | ||
| 1007 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 1320877 | ||||
| 1007 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 35328566 | ||||
| 16130933 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 1320877 | ||||
| 16130933 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 35328566 | ||||
| 16133819 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 1320877 | ||||
| 16133819 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 35328566 | ||||
| 3886 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 1320877 | ||||
| 3886 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 35328566 | ||||
| 44210030 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 1320877 | ||||
| 44210030 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 35328566 | ||||
| 56947141 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 1320877 | ||||
| 56947141 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 35328566 | ||||
| CHEMBL3188091 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 1320877 | ||||
| CHEMBL3188091 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 35328566 | ||||
| DB06138 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 1320877 | ||||
| DB06138 | 10413 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 35328566 | ||||
| 16133801 | 7499 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | None | None | None | None | 7733918 | ||||
| 3859 | 7499 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | None | None | None | None | 7733918 | ||||