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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	CHEMBL3980643	214974	None	0	Human	Functional	pIC50	=	10	10.0	6	2	Agonist activity at human recombinant ETB receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization by fluorimetric methodAgonist activity at human recombinant ETB receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization by fluorimetric method	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)[C@@H](C)CC	10.1016/j.ejmech.2016.06.006
	5311032	60266	None	31	Human	Functional	pIC50	=	9.4	9.4	-	1	Antagonist activity at ETB receptor in human BSMC assessed as inhibition of endothelin-1 or 3-mediated Ca2+ mobilization preincubated for 5 mins followed by endothelin-1 or 3 addition by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETB receptor in human BSMC assessed as inhibition of endothelin-1 or 3-mediated Ca2+ mobilization preincubated for 5 mins followed by endothelin-1 or 3 addition by fura-2/AM dye-based spectrofluorimetric method	ChEMBL	641	12	4	7	4.8	CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O	10.1016/j.ejmech.2016.06.006
	CHEMBL1515091	60266	None	31	Human	Functional	pIC50	=	9.4	9.4	-	1	Antagonist activity at ETB receptor in human BSMC assessed as inhibition of endothelin-1 or 3-mediated Ca2+ mobilization preincubated for 5 mins followed by endothelin-1 or 3 addition by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETB receptor in human BSMC assessed as inhibition of endothelin-1 or 3-mediated Ca2+ mobilization preincubated for 5 mins followed by endothelin-1 or 3 addition by fura-2/AM dye-based spectrofluorimetric method	ChEMBL	641	12	4	7	4.8	CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O	10.1016/j.ejmech.2016.06.006
	CHEMBL1741040	60266	None	31	Human	Functional	pIC50	=	9.4	9.4	-	1	Antagonist activity at ETB receptor in human BSMC assessed as inhibition of endothelin-1 or 3-mediated Ca2+ mobilization preincubated for 5 mins followed by endothelin-1 or 3 addition by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETB receptor in human BSMC assessed as inhibition of endothelin-1 or 3-mediated Ca2+ mobilization preincubated for 5 mins followed by endothelin-1 or 3 addition by fura-2/AM dye-based spectrofluorimetric method	ChEMBL	641	12	4	7	4.8	CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O	10.1016/j.ejmech.2016.06.006
	10187997	110028	None	0	Human	Functional	pIC50	=	9.2	9.2	-4	4	Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.	ChEMBL	564	13	1	7	4.2	CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	CHEMBL323464	110028	None	0	Human	Functional	pIC50	=	9.2	9.2	-4	4	Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.	ChEMBL	564	13	1	7	4.2	CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	1009	194	None	25	Human	Functional	pIC50	=	9.1	9.1	1479	2	EDNRB- dependent phosphatidylinositol hydrolysis assayEDNRB- dependent phosphatidylinositol hydrolysis assay	ChEMBL	558	11	2	6	5.8	CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2	10.6019/CHEMBL4507261
	5310991	194	None	25	Human	Functional	pIC50	=	9.1	9.1	1479	2	EDNRB- dependent phosphatidylinositol hydrolysis assayEDNRB- dependent phosphatidylinositol hydrolysis assay	ChEMBL	558	11	2	6	5.8	CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2	10.6019/CHEMBL4507261
	CHEMBL332794	194	None	25	Human	Functional	pIC50	=	9.1	9.1	1479	2	EDNRB- dependent phosphatidylinositol hydrolysis assayEDNRB- dependent phosphatidylinositol hydrolysis assay	ChEMBL	558	11	2	6	5.8	CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2	10.6019/CHEMBL4507261
	CHEMBL284250	213319	None	0	Human	Functional	pIC50	=	9.1	9.1	1	4	Functional inhibition of ET-1 induced [Ca2+] increase in human Girardi heart (hGH) cells, which express Endothelin B receptorFunctional inhibition of ET-1 induced [Ca2+] increase in human Girardi heart (hGH) cells, which express Endothelin B receptor	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O	10.1016/0960-894X(95)00237-N
	10603409	110667	None	0	Human	Functional	pIC50	=	9.1	9.1	-1	4	Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.	ChEMBL	584	13	1	7	4.1	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl	10.1021/jm970101g
	CHEMBL325581	110667	None	0	Human	Functional	pIC50	=	9.1	9.1	-1	4	Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.	ChEMBL	584	13	1	7	4.1	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl	10.1021/jm970101g
	10210629	8766	None	0	Human	Functional	pIC50	=	9.0	9.0	-7	4	Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.	ChEMBL	592	15	1	7	5.0	CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	CHEMBL109644	8766	None	0	Human	Functional	pIC50	=	9.0	9.0	-7	4	Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.	ChEMBL	592	15	1	7	5.0	CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	CHEMBL3143473	213793	None	0	Human	Functional	pIC50	=	8.9	8.9	1071	2	Antagonistic activity against endothelin B (ETB) receptor using human girardi heart cells.Antagonistic activity against endothelin B (ETB) receptor using human girardi heart cells.	ChEMBL		None	None	None		CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O	10.1016/0960-894X(95)00084-7
	CHEMBL3305972	213793	None	0	Human	Functional	pIC50	=	8.9	8.9	1071	2	Antagonistic activity against endothelin B (ETB) receptor using human girardi heart cells.Antagonistic activity against endothelin B (ETB) receptor using human girardi heart cells.	ChEMBL		None	None	None		CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O	10.1016/0960-894X(95)00084-7
	9916235	9355	None	1	Human	Functional	pIC50	=	8.9	8.9	-4	4	Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.	ChEMBL	578	14	1	7	4.6	CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	CHEMBL111277	9355	None	1	Human	Functional	pIC50	=	8.9	8.9	-4	4	Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.	ChEMBL	578	14	1	7	4.6	CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	10651488	163474	None	0	Human	Functional	pIC50	=	8.8	8.8	-1	4	Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.	ChEMBL	618	13	1	7	4.8	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F	10.1021/jm970101g
	CHEMBL419367	163474	None	0	Human	Functional	pIC50	=	8.8	8.8	-1	4	Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.	ChEMBL	618	13	1	7	4.8	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F	10.1021/jm970101g
	11318978	168006	None	0	Human	Functional	pIC50	=	8.0	8.0	-7	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	560	7	2	6	4.8	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)n1	10.1021/jm031115r
	CHEMBL431286	168006	None	0	Human	Functional	pIC50	=	8.0	8.0	-7	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	560	7	2	6	4.8	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)n1	10.1021/jm031115r
	CHEMBL4533479	216452	None	1	Human	Functional	pIC50	=	6	6.0	1	2	Eurofins cellular functional assay - Antagonist (EDNRB)Eurofins cellular functional assay - Antagonist (EDNRB)	ChEMBL		None	None	None		CCCOc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1	10.6019/CHEMBL4507261
	11387205	111624	None	0	Human	Functional	pIC50	=	7.0	7.0	1	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	544	8	2	7	4.5	COc1ccc(CN2C(=O)CN[C@](C3CCCCC3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1	10.1021/jm031115r
	CHEMBL328073	111624	None	0	Human	Functional	pIC50	=	7.0	7.0	1	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	544	8	2	7	4.5	COc1ccc(CN2C(=O)CN[C@](C3CCCCC3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1	10.1021/jm031115r
	10298354	112069	None	0	Human	Functional	pIC50	=	7.0	7.0	-15	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	462	7	3	7	1.8	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCO)c3ccccc32)n1	10.1021/jm031115r
	CHEMBL328878	112069	None	0	Human	Functional	pIC50	=	7.0	7.0	-15	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	462	7	3	7	1.8	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCO)c3ccccc32)n1	10.1021/jm031115r
	10187313	107500	None	0	Human	Functional	pIC50	=	7.0	7.0	-18	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	544	7	2	6	4.3	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3F)c3ccccc32)n1	10.1021/jm031115r
	CHEMBL318247	107500	None	0	Human	Functional	pIC50	=	7.0	7.0	-18	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	544	7	2	6	4.3	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3F)c3ccccc32)n1	10.1021/jm031115r
	11169125	210018	None	0	Human	Functional	pIC50	=	7.0	7.0	-5	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	574	7	2	4	6.5	Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1	10.1021/jm031115r
	CHEMBL94802	210018	None	0	Human	Functional	pIC50	=	7.0	7.0	-5	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	574	7	2	4	6.5	Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1	10.1021/jm031115r
	10303258	161969	None	0	Human	Functional	pIC50	=	8.0	8.0	-3	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	564	10	2	6	5.3	CCCCc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1	10.1021/jm031115r
	CHEMBL415010	161969	None	0	Human	Functional	pIC50	=	8.0	8.0	-3	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	564	10	2	6	5.3	CCCCc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1	10.1021/jm031115r
	9957883	98710	None	0	Human	Functional	pIC50	=	6.0	6.0	-25	2	Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin B receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin B receptor.	ChEMBL	507	7	1	9	5.0	COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC	10.1016/0960-894X(96)00232-6
	CHEMBL27732	98710	None	0	Human	Functional	pIC50	=	6.0	6.0	-25	2	Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin B receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin B receptor.	ChEMBL	507	7	1	9	5.0	COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC	10.1016/0960-894X(96)00232-6
	9890440	8256	None	0	Human	Functional	pIC50	=	5.9	5.9	-301	2	Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).	ChEMBL	460	6	1	7	4.1	COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1	10.1021/jm00008a002
	CHEMBL10924	8256	None	0	Human	Functional	pIC50	=	5.9	5.9	-301	2	Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).	ChEMBL	460	6	1	7	4.1	COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1	10.1021/jm00008a002
	11753582	210047	None	0	Human	Functional	pIC50	=	6.9	6.9	-4	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	586	7	2	6	4.8	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Br)cc3)c3ccccc32)n1	10.1021/jm031115r
	CHEMBL94962	210047	None	0	Human	Functional	pIC50	=	6.9	6.9	-4	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	586	7	2	6	4.8	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Br)cc3)c3ccccc32)n1	10.1021/jm031115r
	3951	391	None	55	Human	Functional	pIC50	=	5.9	5.9	-47	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	378	7	1	5	3.5	COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1	10.1021/jm031115r
	4337	391	None	55	Human	Functional	pIC50	=	5.9	5.9	-47	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	378	7	1	5	3.5	COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1	10.1021/jm031115r
	6918493	391	None	55	Human	Functional	pIC50	=	5.9	5.9	-47	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	378	7	1	5	3.5	COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1	10.1021/jm031115r
	6918493.0	391	None	55	Human	Functional	pIC50	=	5.9	5.9	-47	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	378	7	1	5	3.5	COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1	10.1021/jm031115r
	CHEMBL1111	391	None	55	Human	Functional	pIC50	=	5.9	5.9	-47	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	378	7	1	5	3.5	COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1	10.1021/jm031115r
	DB06403	391	None	55	Human	Functional	pIC50	=	5.9	5.9	-47	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	378	7	1	5	3.5	COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1	10.1021/jm031115r
	11753090	106259	None	0	Human	Functional	pIC50	=	6.9	6.9	-7	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	542	7	2	6	4.7	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Cl)cc3)c3ccccc32)n1	10.1021/jm031115r
	CHEMBL313870	106259	None	0	Human	Functional	pIC50	=	6.9	6.9	-7	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	542	7	2	6	4.7	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Cl)cc3)c3ccccc32)n1	10.1021/jm031115r
	11398658	210058	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	544	7	2	6	4.3	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)cc(F)c3)c3ccccc32)n1	10.1021/jm031115r
	CHEMBL95017	210058	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	544	7	2	6	4.3	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)cc(F)c3)c3ccccc32)n1	10.1021/jm031115r
	10120430	209979	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	2	Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand	ChEMBL	562	7	2	6	4.4	Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)ccc(F)c3F)c3ccccc32)n1	10.1021/jm031115r

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	4236	28104	None	33	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	273	5	1	2	2.0	NC(=O)C[S+]([O-])C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1373	28104	None	33	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	273	5	1	2	2.0	NC(=O)C[S+]([O-])C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	104865	706	None	60	Human	Binding	pAC50	=	6.6	6.6	-6	4	Binding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	551	10	2	10	4.2	OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1	10.1038/s41467-023-40064-9
	104865.0	706	None	60	Human	Binding	pAC50	=	6.6	6.6	-6	4	Binding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	551	10	2	10	4.2	OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1	10.1038/s41467-023-40064-9
	3494	706	None	60	Human	Binding	pAC50	=	6.6	6.6	-6	4	Binding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	551	10	2	10	4.2	OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1	10.1038/s41467-023-40064-9
	392	706	None	60	Human	Binding	pAC50	=	6.6	6.6	-6	4	Binding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	551	10	2	10	4.2	OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1	10.1038/s41467-023-40064-9
	CHEMBL957	706	None	60	Human	Binding	pAC50	=	6.6	6.6	-6	4	Binding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	551	10	2	10	4.2	OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1	10.1038/s41467-023-40064-9
	DB00559	706	None	60	Human	Binding	pAC50	=	6.6	6.6	-6	4	Binding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	551	10	2	10	4.2	OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1	10.1038/s41467-023-40064-9
	4020	207608	None	20	Human	Binding	pAC50	=	4.5	4.5	-	1	Binding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	284	1	1	3	2.6	OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21	10.1038/s41467-023-40064-9
	CHEMBL781	207608	None	20	Human	Binding	pAC50	=	4.5	4.5	-	1	Binding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	284	1	1	3	2.6	OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21	10.1038/s41467-023-40064-9
	CHEMBL2370066	212236	None	0	Rat	Binding	pEC50	=	6.8	6.8	-	0	Effective concentration against Endothelin B receptor from rat cerebellumEffective concentration against Endothelin B receptor from rat cerebellum	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC	10.1021/jm00070a001
	CHEMBL2370067	212237	None	0	Rat	Binding	pEC50	=	5.7	5.7	-	0	Effective concentration against Endothelin B receptor from rat cerebellumEffective concentration against Endothelin B receptor from rat cerebellum	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@H](C=O)Cc1c[nH]c2ccccc12)[C@@H](C)CC	10.1021/jm00070a001
	CHEMBL315841	213652	None	0	Rat	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration against Endothelin B receptor from rat cerebellumEffective concentration against Endothelin B receptor from rat cerebellum	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O	10.1021/jm00070a001
	CHEMBL407269	215111	None	0	Rat	Binding	pEC50	=	7.3	7.3	-	0	Effective concentration against Endothelin B receptor from rat cerebellumEffective concentration against Endothelin B receptor from rat cerebellum	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC	10.1021/jm00070a001
	CHEMBL387200	214868	None	0	Rat	Binding	pEC50	=	7.2	7.2	-	0	Effective concentration against Endothelin B receptor from rat cerebellumEffective concentration against Endothelin B receptor from rat cerebellum	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC	10.1021/jm00070a001
	CHEMBL86703	218379	None	0	Rat	Binding	pEC50	=	5.2	5.2	-	0	Effective concentration against Endothelin B receptor from rat cerebellumEffective concentration against Endothelin B receptor from rat cerebellum	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C	10.1021/jm00070a001
	CHEMBL313344	213571	None	0	Rat	Binding	pEC50	=	5.2	5.2	-	0	Effective concentration against Endothelin B receptor from rat cerebellumEffective concentration against Endothelin B receptor from rat cerebellum	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC	10.1021/jm00070a001
	CHEMBL1790180	211342	None	0	Human	Binding	pIC50	=	10.5	10.5	-1	3	Binding affinity to human ETB receptor by radioligand displacement assayBinding affinity to human ETB receptor by radioligand displacement assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC	10.1016/j.ejmech.2013.01.044
	CHEMBL1790180	211342	None	0	Human	Binding	pIC50	=	10.4	10.4	-1	3	Binding affinity to human ETB receptor by radioligand displacement assayBinding affinity to human ETB receptor by radioligand displacement assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC	10.1016/j.bmc.2013.03.016
	CHEMBL1790180	211342	None	0	Human	Binding	pIC50	=	10.0	10.0	-1	3	Displacement of radiolabeled endothelin-3 from human endothelin ETB receptorDisplacement of radiolabeled endothelin-3 from human endothelin ETB receptor	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC	10.1021/jm8007618
	44284481	216186	None	0	Human	Binding	pIC50	=	9.9	9.9	-4	5	Displacement of [125I]Endothelin-1 from human recombinant ETB receptor expressed in CHOK1 cells after 2 hrsDisplacement of [125I]Endothelin-1 from human recombinant ETB receptor expressed in CHOK1 cells after 2 hrs	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC	10.1016/j.bmcl.2013.01.025
	CHEMBL437472	216186	None	0	Human	Binding	pIC50	=	9.9	9.9	-4	5	Displacement of [125I]Endothelin-1 from human recombinant ETB receptor expressed in CHOK1 cells after 2 hrsDisplacement of [125I]Endothelin-1 from human recombinant ETB receptor expressed in CHOK1 cells after 2 hrs	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC	10.1016/j.bmcl.2013.01.025
	10603409	110667	None	0	Human	Binding	pIC50	=	9.9	9.9	-	0	Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)	ChEMBL	584	13	1	7	4.1	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl	10.1021/jm970101g
	CHEMBL325581	110667	None	0	Human	Binding	pIC50	=	9.9	9.9	-	0	Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)	ChEMBL	584	13	1	7	4.1	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl	10.1021/jm970101g
	10603409	110667	None	0	Pig	Binding	pIC50	=	9.7	9.7	-	0	Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.	ChEMBL	584	13	1	7	4.1	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl	10.1021/jm970101g
	CHEMBL325581	110667	None	0	Pig	Binding	pIC50	=	9.7	9.7	-	0	Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.	ChEMBL	584	13	1	7	4.1	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl	10.1021/jm970101g
	10651488	163474	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)	ChEMBL	618	13	1	7	4.8	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F	10.1021/jm970101g
	CHEMBL419367	163474	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)	ChEMBL	618	13	1	7	4.8	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F	10.1021/jm970101g
	44284481	216186	None	0	Human	Binding	pIC50	=	9.7	9.7	-4	5	Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorReceptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptor	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC	10.1016/S0960-894X(97)00400-9
	CHEMBL437472	216186	None	0	Human	Binding	pIC50	=	9.7	9.7	-4	5	Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorReceptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptor	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC	10.1016/S0960-894X(97)00400-9
	CHEMBL2165327	211791	None	5	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [I125]ET1 from recombinant ETB receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETB receptor expressed in CHO cells after 2 hrs by TopCount analysis	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O	10.1021/jm3009103
	10839947	117366	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	Binding affinity towards human Endothelin B receptor (hET -B)Binding affinity towards human Endothelin B receptor (hET -B)	ChEMBL	530	9	2	6	5.0	CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1	10.1021/jm990170q
	CHEMBL339657	117366	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	Binding affinity towards human Endothelin B receptor (hET -B)Binding affinity towards human Endothelin B receptor (hET -B)	ChEMBL	530	9	2	6	5.0	CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1	10.1021/jm990170q
	9916235	9355	None	1	Human	Binding	pIC50	=	9.6	9.6	-	0	Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)	ChEMBL	578	14	1	7	4.6	CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	CHEMBL111277	9355	None	1	Human	Binding	pIC50	=	9.6	9.6	-	0	Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)	ChEMBL	578	14	1	7	4.6	CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	9916235	9355	None	1	Pig	Binding	pIC50	=	9.5	9.5	-	0	Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.	ChEMBL	578	14	1	7	4.6	CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	CHEMBL111277	9355	None	1	Pig	Binding	pIC50	=	9.5	9.5	-	0	Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.	ChEMBL	578	14	1	7	4.6	CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	10187997	110028	None	0	Pig	Binding	pIC50	=	9.5	9.5	-	0	Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.	ChEMBL	564	13	1	7	4.2	CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	CHEMBL323464	110028	None	0	Pig	Binding	pIC50	=	9.5	9.5	-	0	Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.	ChEMBL	564	13	1	7	4.2	CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	10651488	163474	None	0	Pig	Binding	pIC50	=	9.5	9.5	-	0	Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.	ChEMBL	618	13	1	7	4.8	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F	10.1021/jm970101g
	CHEMBL419367	163474	None	0	Pig	Binding	pIC50	=	9.5	9.5	-	0	Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.	ChEMBL	618	13	1	7	4.8	CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F	10.1021/jm970101g
	10210629	8766	None	0	Pig	Binding	pIC50	=	9.5	9.5	-	0	Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.	ChEMBL	592	15	1	7	5.0	CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	CHEMBL109644	8766	None	0	Pig	Binding	pIC50	=	9.5	9.5	-	0	Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.	ChEMBL	592	15	1	7	5.0	CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	10187997	110028	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)	ChEMBL	564	13	1	7	4.2	CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	CHEMBL323464	110028	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)	ChEMBL	564	13	1	7	4.2	CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	10210629	8766	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)	ChEMBL	592	15	1	7	5.0	CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	CHEMBL109644	8766	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)	ChEMBL	592	15	1	7	5.0	CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1	10.1021/jm970101g
	10555806	12126	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptorBinding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptor	ChEMBL	616	12	2	7	6.0	CC(C)OCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1	10.1021/jm990171i
	CHEMBL1184095	12126	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptorBinding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptor	ChEMBL	616	12	2	7	6.0	CC(C)OCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1	10.1021/jm990171i
	CHEMBL332289	12126	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptorBinding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptor	ChEMBL	616	12	2	7	6.0	CC(C)OCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1	10.1021/jm990171i

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