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Ligand source activities (1 row/activity)
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
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Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
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Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
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Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
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Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
3-methylhexanal | 106 | None | 0 | Human | Functional | pIC50 | = | - | 4.13 | - | 1 | Unclassified | Guide to Pharmacology | 114.1 | 4 | 0 | 1 | 2.01 | CCCC(C)CC=O | https://pubmed.ncbi.nlm.nih.gov/27569025 | |
acesulfame | 253 | None | 0 | Human | Functional | pEC50 | = | - | 2.51 | -1 | 2 | Unclassified | Guide to Pharmacology | 163.0 | 0 | 1 | 4 | -0.72 | CC1=CC(=O)NS(=O)(=O)O1 | https://pubmed.ncbi.nlm.nih.gov/15537898 | |
aloin | 354 | None | 0 | Human | Functional | pEC50 | = | - | 5.92 | - | 1 | Unclassified | Guide to Pharmacology | 418.1 | 3 | 7 | 9 | -0.89 | O=C1c2c(O)cccc2C([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cc(CO)cc(O)c21 | https://pubmed.ncbi.nlm.nih.gov/17702579 | |
amarogentin | 390 | None | 0 | Human | Functional | pEC50 | = | - | 4.12 | -186 | 4 | Unclassified | Guide to Pharmacology | 586.2 | 7 | 6 | 13 | 1.06 | C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2OC(=O)c2c(O)cc(O)cc2-c2cccc(O)c2)OC=C2C(=O)OCC[C@H]21 | https://pubmed.ncbi.nlm.nih.gov/20022913 | |
aristolochic acid | 471 | None | 0 | Human | Functional | pEC50 | = | - | 7.10 | 5 | 3 | Unclassified | Guide to Pharmacology | 341.1 | 3 | 1 | 6 | 3.34 | COc1cccc2c1cc([N+](=O)[O-])c1c(C(=O)O)cc3c(c12)OCO3 | https://pubmed.ncbi.nlm.nih.gov/15537898 | |
bengalensol | 595 | None | 0 | Human | Functional | pEC50 | = | - | 5.41 | 3 | 2 | Unclassified | Guide to Pharmacology | 330.2 | 1 | 1 | 4 | 2.60 | C[C@@]12CC(=O)C3=C(CCO3)[C@H]1CC[C@]13C[C@H]4C[C@H](O[C@]4(CO)C1)[C@H]32 | https://pubmed.ncbi.nlm.nih.gov/32437139 | |
citronellal | 945 | None | 0 | Human | Functional | pIC50 | = | - | 4.08 | - | 1 | Unclassified | Guide to Pharmacology | 154.1 | 5 | 0 | 1 | 2.96 | CC(C)=CCCC(C)CC=O | https://pubmed.ncbi.nlm.nih.gov/27569025 | |
cyclamate | 1276 | None | 0 | Human | Functional | pIC50 | = | - | 2.32 | 3 | 2 | Unclassified | Guide to Pharmacology | 179.1 | 2 | 2 | 2 | 0.71 | O=S(=O)(O)NC1CCCCC1 | https://pubmed.ncbi.nlm.nih.gov/28919036 | |
Cyclolinopeptide 1-Mso,3-Met-CL6 | 1284 | None | 0 | Human | Functional | pEC50 | = | - | 5.53 | - | 1 | Unclassified | Guide to Pharmacology | - | - | - | - | - | - | https://pubmed.ncbi.nlm.nih.gov/35364812 | |
GIV3727 | 1802 | None | 0 | Human | Functional | pIC50 | = | - | 4.95 | -3 | 3 | Unclassified | Guide to Pharmacology | 198.2 | 4 | 1 | 1 | 3.31 | CC1CCC(CCCC(=O)O)C1(C)C | https://pubmed.ncbi.nlm.nih.gov/20537538 | |
grosheimin | 1864 | None | 0 | Human | Functional | pEC50 | = | - | 5.16 | -1 | 2 | Unclassified | Guide to Pharmacology | 262.1 | 0 | 1 | 4 | 1.25 | C=C1C[C@H](O)[C@H]2C(=C)C(=O)O[C@@H]2[C@H]2[C@H](C)C(=O)C[C@@H]12 | https://pubmed.ncbi.nlm.nih.gov/26406243 | |
isoprenaline | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.31 | 8.08 | -63 | 49 | Agonist activity at human TAS2R43 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay | Drug Central | 211.1 | 4 | 4 | 4 | 1.13 | CC(C)NCC(O)c1ccc(O)c(O)c1 | - | |
isoprenaline | 2091 | None | 34 | Human | Functional | EC50 | = | 4.90 | 8.31 | -63 | 49 | Agonist activity at human TAS2R43 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay | ChEMBL | 211.1 | 4 | 4 | 4 | 1.13 | CC(C)NCC(O)c1ccc(O)c(O)c1 | - | |
lactucopicrin | 2269 | None | 0 | Human | Functional | pEC50 | = | - | 6.34 | -1 | 2 | Unclassified | Guide to Pharmacology | 410.1 | 4 | 2 | 7 | 1.78 | C=C1C(=O)O[C@@H]2[C@H]3C(CO)=CC(=O)C3=C(C)C[C@H](OC(=O)Cc3ccc(O)cc3)[C@@H]12 | https://pubmed.ncbi.nlm.nih.gov/36601079 | |
saccharin | 3457 | None | 0 | Human | Functional | pEC50 | = | - | 2.77 | -1 | 2 | Unclassified | Guide to Pharmacology | 183.0 | 0 | 1 | 3 | 0.12 | O=C1NS(=O)(=O)c2ccccc21 | https://pubmed.ncbi.nlm.nih.gov/15537898 |
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