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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

α-methylserine-O-phosphate	365	None	0	Rat	Binding	pKi	None	-	5.30	7	4	Unclassified	Guide to Pharmacology	199.0	4	4	4	-1.10	CC(N)(COP(=O)(O)O)C(=O)O	https://pubmed.ncbi.nlm.nih.gov/9504391
(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid	218819	3H-LY341495	0	Human	Binding	pKi	=	84.70	7.07	-3	3	-	PDSP KiDatabase	185.1	2	3	3	-0.49	NC1(C(=O)O)CCC2C(C(=O)O)C21	-
(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid	218819	3H-LY354740	0	Rat	Binding	pKi	=	9.00	8.05	3	3	-	PDSP KiDatabase	185.1	2	3	3	-0.49	NC1(C(=O)O)CCC2C(C(=O)O)C21	-
(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid	218819	3H-LY341495	0	Rat	Binding	pKi	=	80.00	7.10	3	3	-	PDSP KiDatabase	185.1	2	3	3	-0.49	NC1(C(=O)O)CCC2C(C(=O)O)C21	-
(+)-MCPG	2475	None	35	Human	Binding	pKi	None	-	3.80	-6	8	Unclassified	Guide to Pharmacology	209.1	3	3	3	0.64	C[C@@](N)(C(=O)O)c1ccc(C(=O)O)cc1	https://pubmed.ncbi.nlm.nih.gov/10530814
(+)-MCPG	2475	None	35	Rat	Binding	pKi	None	-	4.60	6	8	Unclassified	Guide to Pharmacology	209.1	3	3	3	0.64	C[C@@](N)(C(=O)O)c1ccc(C(=O)O)cc1	https://pubmed.ncbi.nlm.nih.gov/9504391
(+)-t-ADA	218849	Functional	0	Human	Binding	pKi	=	10000.00	5.00	1	2	-	PDSP KiDatabase	145.0	2	3	3	-1.11	O=C(O)C1CC(C(=O)O)N1	-
(+)-t-ADA	218849	Functional	0	Rat	Binding	pKi	=	10000.00	5.00	-1	2	-	PDSP KiDatabase	145.0	2	3	3	-1.11	O=C(O)C1CC(C(=O)O)N1	-
(-)-2-aminoadipic acid	218977	Functional	0	Rat	Binding	pKi	=	10000.00	5.00	1	2	-	PDSP KiDatabase	161.1	5	3	3	-0.35	NC(CCCC(=O)O)C(=O)O	-
(1R,2S)-PHENYLPROPANOLAMINE	27120	Functional	13	Rat	Binding	pKi	=	10000.00	5.00	-38	42	-	PDSP KiDatabase	151.1	2	2	2	1.07	C[C@H](N)[C@H](O)c1ccccc1	-
(1S,3R)-ACPD	33	None	30	Human	Binding	pKi	None	-	4.20	-11	15	Unclassified	Guide to Pharmacology	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/10530814
(1S,3R)-ACPD	33	None	30	Human	Binding	EC50	=	12100.00	4.92	-11	15	Concentration for half maximal activation of metabotropic glutamate mGluR2 in human	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm00009a001
(1S,3R)-ACPD	33	None	30	Human	Binding	EC50	=	2000.00	5.70	-11	15	Compound was tested for the inhibition of metabotropic glutamate receptor 2 (mGluR2).	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm970719q
(1S,3R)-ACPD	33	None	30	Rat	Binding	pKi	None	-	5.20	-3	15	Unclassified	Guide to Pharmacology	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/9504391
(1S,3R)-ACPD	33	None	30	Rat	Binding	pKi	None	-	5.20	-3	15	Unclassified	Guide to Pharmacology	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/10884552
(1S,3R)-ACPD	33	None	30	Rat	Binding	EC50	=	7700.00	5.11	-3	15	Concentration for half maximal activation of metabotropic glutamate mGluR2 in rat	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm00009a001
(1S,3R)-ACPD	33	None	30	Rat	Binding	EC50	=	5000.00	5.30	-3	15	Concentration for half maximal activation of metabotropic glutamate mGluR2 in rat	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm00009a001
(2R,3R)-APDC	73	None	32	Human	Binding	pKi	None	-	5.00	-1	5	Unclassified	Guide to Pharmacology	174.1	2	4	4	-1.78	N[C@@]1(C(=O)O)CN[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/10530814
(S)-2-AMINOADIPIC ACID	209028	None	52	Rat	Binding	EC50	=	35000.00	4.46	-	2	Effect on Metabotropic glutamate receptor 2	ChEMBL	161.1	5	3	3	-0.35	N[C@@H](CCCC(=O)O)C(=O)O	https://dx.doi.org/10.1021/jm9703597
(S)-2-AMINOADIPIC ACID	209028	None	52	Rat	Binding	EC50	=	35000.00	4.46	-	2	Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2	ChEMBL	161.1	5	3	3	-0.35	N[C@@H](CCCC(=O)O)C(=O)O	https://dx.doi.org/10.1021/jm020122x

Showing 1 to 20 of 1,391 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(+)-MCPG	2475	None	35	Human	Functional	IC50	=	4300.00	5.37	-1	8	Antagonist activity at mGlu2 receptor	ChEMBL	209.1	3	3	3	0.64	C[C@@](N)(C(=O)O)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1021/jm060950g
(1S,3R)-ACPD	33	None	30	Human	Functional	EC50	=	18000.00	4.75	-2	15	Agonist activity against Metabotropic glutamate receptor 2 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm970207b
(1S,3R)-ACPD	33	None	30	Human	Functional	Ki	=	5000.00	5.30	-2	15	Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm000007r
(1S,3R)-ACPD	33	None	30	Rat	Functional	EC50	=	5000.00	5.30	2	15	Tested for the agonistic activity against Metabotropic glutamate receptor 2	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1016/S0960-894X(97)00068-1
(1S,3R)-ACPD	33	None	30	Rat	Functional	EC50	=	2000.00	5.70	2	15	Activity tested at cloned rat mGluR2 receptor expressed in Chinese Hamster Ovary (CHO) cells	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm0308085
(1S,3R)-ACPD	33	None	30	Rat	Functional	EC50	=	2100.00	5.68	2	15	Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptor	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1016/s0960-894x(99)00266-8
(2R,3R)-APDC	73	None	32	Human	Functional	Ki	=	450.00	6.35	-	5	Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).	ChEMBL	174.1	2	4	4	-1.78	N[C@@]1(C(=O)O)CN[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm000007r
(2R,3R)-APDC	73	None	32	Rat	Functional	EC50	=	480.00	6.32	5	5	Effective concentration required for agonistic activity at Metabotropic glutamate receptor 2	ChEMBL	174.1	2	4	4	-1.78	N[C@@]1(C(=O)O)CN[C@@H](C(=O)O)C1	https://dx.doi.org/10.1016/s0960-894x(01)00329-8
(2R,3R)-APDC	73	None	32	Rat	Functional	EC50	=	300.00	6.52	5	5	Tested for the agonistic activity against Metabotropic glutamate receptor 2	ChEMBL	174.1	2	4	4	-1.78	N[C@@]1(C(=O)O)CN[C@@H](C(=O)O)C1	https://dx.doi.org/10.1016/S0960-894X(97)00068-1
(2R,3R)-APDC	73	None	32	Rat	Functional	EC50	=	200.00	6.70	5	5	Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptor	ChEMBL	174.1	2	4	4	-1.78	N[C@@]1(C(=O)O)CN[C@@H](C(=O)O)C1	https://dx.doi.org/10.1016/s0960-894x(99)00266-8
(S)-2-AMINOADIPIC ACID	209028	None	52	Human	Functional	EC50	=	35000.00	4.46	1	2	Agonistic activity at mGlu2 receptor expressed in CHO cells	ChEMBL	161.1	5	3	3	-0.35	N[C@@H](CCCC(=O)O)C(=O)O	https://dx.doi.org/10.1021/jm9602569
(S)-2-AMINOADIPIC ACID	209028	None	52	Human	Functional	Ki	=	35000.00	4.46	1	2	Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).	ChEMBL	161.1	5	3	3	-0.35	N[C@@H](CCCC(=O)O)C(=O)O	https://dx.doi.org/10.1021/jm000007r
(S)-4C3HPG	2081	None	25	Human	Functional	EC50	=	48000.00	4.32	-19	5	Agonist activity at mGlu2 receptor	ChEMBL	211.0	3	4	4	0.17	N[C@H](C(=O)O)c1ccc(C(=O)O)c(O)c1	https://dx.doi.org/10.1021/jm060950g
2,2,2-TEMPS	42	None	1	Human	Functional	pEC50	=	-	7.85	-	2	Unclassified	Guide to Pharmacology	416.1	9	0	4	4.55	CCCC(C)Oc1cccc(N(Cc2cccnc2)S(=O)(=O)CC(F)(F)F)c1	https://pubmed.ncbi.nlm.nih.gov/15149652
2,2,2-TEMPS	42	None	1	Human	Functional	EC50	=	30.90	7.51	-	2	Allosteric modulation of human mGluR2 expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	416.1	9	0	4	4.55	CCCC(C)Oc1cccc(N(Cc2cccnc2)S(=O)(=O)CC(F)(F)F)c1	https://dx.doi.org/10.1016/j.bmcl.2009.11.008
3-MPPTS	107	None	0	Human	Functional	pIC50	None	-	6.60	-	1	Unclassified	Guide to Pharmacology	452.1	8	0	5	4.78	COc1ccccc1Oc1cccc(N(Cc2cccnc2)S(=O)(=O)CC(F)(F)F)c1	https://pubmed.ncbi.nlm.nih.gov/12852748
3-MPPTS	107	None	0	Human	Functional	pIC50	None	-	6.60	-	1	Unclassified	Guide to Pharmacology	452.1	8	0	5	4.78	COc1ccccc1Oc1cccc(N(Cc2cccnc2)S(=O)(=O)CC(F)(F)F)c1	https://pubmed.ncbi.nlm.nih.gov/14500736
3-MPPTS	107	None	0	Human	Functional	pIC50	None	-	6.60	-	1	Unclassified	Guide to Pharmacology	452.1	8	0	5	4.78	COc1ccccc1Oc1cccc(N(Cc2cccnc2)S(=O)(=O)CC(F)(F)F)c1	https://pubmed.ncbi.nlm.nih.gov/15717213
4-APPES	113	None	0	Human	Functional	pEC50	=	-	5.65	-	1	Unclassified	Guide to Pharmacology	411.1	8	1	5	3.33	CCS(=O)(=O)N(Cc1cccnc1)c1ccc(Oc2ccc(C(N)=O)cc2)cc1	https://pubmed.ncbi.nlm.nih.gov/15717213
4-MPPTS	122	None	35	Human	Functional	pIC50	=	-	5.80	-	1	Unclassified	Guide to Pharmacology	452.1	8	0	5	4.78	COc1ccccc1Oc1ccc(N(Cc2cccnc2)S(=O)(=O)CC(F)(F)F)cc1	https://pubmed.ncbi.nlm.nih.gov/12852748

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Ligand source activities (1 row/activity)