GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	118037818	134186	0	None	1	2	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	428	4	2	4	4.9	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccc2c(c1)OCO2	nan
	CHEMBL3718470	134186	0	None	1	2	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	428	4	2	4	4.9	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccc2c(c1)OCO2	nan
	90010773	133388	0	None	1	2	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	375	4	2	4	4.2	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccno1	nan
	CHEMBL3715750	133388	0	None	1	2	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	375	4	2	4	4.2	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccno1	nan
	127024071	133502	0	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	361	4	3	2	4.9	O=C(Nc1ccc2cc[nH]c2c1)c1ccccc1NC(=O)C1CCCCC1	nan
	CHEMBL3716158	133502	0	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	361	4	3	2	4.9	O=C(Nc1ccc2cc[nH]c2c1)c1ccccc1NC(=O)C1CCCCC1	nan
	12503	1107	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Determined in a HTRF cAMP assay using HEK-RXFP2 cells.Determined in a HTRF cAMP assay using HEK-RXFP2 cells.	Guide to Pharmacology	787	5	1	5	6.6	FC(F)(F)OC1=CC(I)=C(OCC(=O)N2CCN3[C@@H](C2)C(=O)NC4=C(C=C(C=C4)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F)C3=O)C=C1	36333465
	167993647	1107	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Determined in a HTRF cAMP assay using HEK-RXFP2 cells.Determined in a HTRF cAMP assay using HEK-RXFP2 cells.	Guide to Pharmacology	787	5	1	5	6.6	FC(F)(F)OC1=CC(I)=C(OCC(=O)N2CCN3[C@@H](C2)C(=O)NC4=C(C=C(C=C4)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F)C3=O)C=C1	36333465
	11914	2014	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Receptor activationReceptor activation	Guide to Pharmacology		None	None	None		None	22654853
	8346	200	0	None	-165	2	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21878627
	1989	3253	0	None	-17	3	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11913	2691	0	None	-	1	Human	8.7	pKd	=	8.7	Binding	Receptor binding affinityReceptor binding affinity	Guide to Pharmacology		None	None	None		None	24056075
	1995	2013	0	None	16982	2	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	3875	1569	0	None	-	1	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18529069
	11914	2014	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor bindingReceptor binding	Guide to Pharmacology		None	None	None		None	22654853
	3885	2015	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16547350
	8346	200	0	None	-9	2	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21878627
	8333	1253	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	17120268
	8332	279	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20570702
	1989	3253	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1989	3253	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	155817469	2016	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20560146
	4372	2016	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20560146
	8331	231	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20570702
	155817501	189	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	8330	189	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	134813893	212	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	8329	212	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	1995	2013	0	None	16982	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1995	2013	0	None	16982	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	1990	3256	0	None	-81	4	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16411781
	1994	3251	0	None	-39	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1992	3252	0	None	-15	2	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1988	3254	0	None	-	1	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16411781

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Ligand source activities (1 row/activity)