GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	118037818	141487	0	None	1	2	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	428	4	2	4	4.9	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccc2c(c1)OCO2	nan
	CHEMBL3718470	141487	0	None	1	2	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	428	4	2	4	4.9	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccc2c(c1)OCO2	nan
	90010773	140689	0	None	1	2	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	375	4	2	4	4.2	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccno1	nan
	CHEMBL3715750	140689	0	None	1	2	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	375	4	2	4	4.2	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccno1	nan
	127024071	140803	0	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	361	4	3	2	4.9	O=C(Nc1ccc2cc[nH]c2c1)c1ccccc1NC(=O)C1CCCCC1	nan
	CHEMBL3716158	140803	0	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	361	4	3	2	4.9	O=C(Nc1ccc2cc[nH]c2c1)c1ccccc1NC(=O)C1CCCCC1	nan
	12503	7911	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Determined in a HTRF cAMP assay using HEK-RXFP2 cells.Determined in a HTRF cAMP assay using HEK-RXFP2 cells.	Guide to Pharmacology	787	5	1	5	6.6	FC(F)(F)OC1=CC(I)=C(OCC(=O)N2CCN3[C@@H](C2)C(=O)NC4=C(C=C(C=C4)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F)C3=O)C=C1	36333465
	167993647	7911	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Determined in a HTRF cAMP assay using HEK-RXFP2 cells.Determined in a HTRF cAMP assay using HEK-RXFP2 cells.	Guide to Pharmacology	787	5	1	5	6.6	FC(F)(F)OC1=CC(I)=C(OCC(=O)N2CCN3[C@@H](C2)C(=O)NC4=C(C=C(C=C4)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F)C3=O)C=C1	36333465
	11914	8826	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Receptor activationReceptor activation	Guide to Pharmacology		None	None	None		None	22654853
	8346	6990	0	None	-165	2	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21878627
	1989	10076	0	None	-17	3	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11913	9508	0	None	-	1	Human	8.7	pKd	=	8.7	Binding	Receptor binding affinityReceptor binding affinity	Guide to Pharmacology		None	None	None		None	24056075
	1995	8825	0	None	16982	2	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	3875	8380	0	None	-	1	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18529069
	11914	8826	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor bindingReceptor binding	Guide to Pharmacology		None	None	None		None	22654853
	3885	8827	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16547350
	8346	6990	0	None	-9	2	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21878627
	8333	8062	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	17120268
	8332	7070	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20570702
	1989	10076	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1989	10076	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	155817469	8828	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20560146
	4372	8828	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20560146
	8331	7021	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20570702
	155817501	6978	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	8330	6978	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	134813893	7002	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	8329	7002	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	1995	8825	0	None	16982	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1995	8825	0	None	16982	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	1990	10081	0	None	-81	4	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16411781
	1994	10075	0	None	-39	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1992	10078	0	None	-15	2	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1988	10079	0	None	-	1	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16411781

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Ligand source activities (1 row/activity)