GPCRdb

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

CHEMBL153043	45745	None	0	Human	Binding	EC50	=	58.00	7.24	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL153043	45745	None	0	Human	Binding	EC50	=	58.88	7.23	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2017139	73546	None	0	Human	Binding	EC50	=	86.00	7.07	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.85	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2017139	73546	None	0	Human	Binding	EC50	=	85.11	7.07	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.85	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335047	87558	None	0	Human	Binding	EC50	=	90.00	7.05	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOC[C@@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335047	87558	None	0	Human	Binding	EC50	=	89.13	7.05	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOC[C@@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335048	87559	None	0	Human	Binding	EC50	=	105.00	6.98	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOC[C@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335048	87559	None	0	Human	Binding	EC50	=	104.71	6.98	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOC[C@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335052	87560	None	0	Human	Binding	EC50	=	39.00	7.41	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOCC(COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2335052	87560	None	0	Human	Binding	EC50	=	38.90	7.41	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	454.3	23	2	4	6.50	CCCCCCCCCCCCCCCCCCOCC(COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2364959	89093	None	0	Human	Binding	EC50	=	76.00	7.12	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2364959	89093	None	0	Human	Binding	EC50	=	75.86	7.12	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2365070	89102	None	0	Human	Binding	EC50	=	66.00	7.18	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	426.3	21	2	4	5.72	CCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2365070	89102	None	0	Human	Binding	EC50	=	66.07	7.18	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	426.3	21	2	4	5.72	CCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2365071	89103	None	0	Human	Binding	EC50	=	78.00	7.11	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	440.3	22	2	4	6.12	CCCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL2365071	89103	None	0	Human	Binding	EC50	=	77.62	7.11	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	440.3	22	2	4	6.12	CCCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL357053	121145	None	0	Human	Binding	EC50	=	79.00	7.10	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL357053	121145	None	0	Human	Binding	EC50	=	79.43	7.10	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	468.3	22	2	5	6.03	CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](COP(O)(O)=S)OC	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL364797	125870	None	15	Human	Binding	EC50	=	930.00	6.03	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	410.2	19	3	5	4.48	CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O	https://dx.doi.org/10.1016/j.bmcl.2013.01.002
CHEMBL364797	125870	None	15	Human	Binding	EC50	=	933.25	6.03	-	6	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	ChEMBL	410.2	19	3	5	4.48	CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O	https://dx.doi.org/10.1016/j.bmcl.2013.01.002

Showing 1 to 20 of 22 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

LPA	2355	None	15	Human	Functional	pEC50	None	-	6.00	-125	13	Unclassified	Guide to Pharmacology	436.3	20	3	5	5.04	CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)COP(=O)(O)O	https://pubmed.ncbi.nlm.nih.gov/19386608
LPA	2355	None	15	Human	Functional	pEC50	None	-	6.00	-125	13	Unclassified	Guide to Pharmacology	436.3	20	3	5	5.04	CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)COP(=O)(O)O	https://pubmed.ncbi.nlm.nih.gov/18297070
LPA	2355	None	15	Mouse	Functional	pEC50	=	-	6.00	-125	13	Unclassified	Guide to Pharmacology	436.3	20	3	5	5.04	CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)COP(=O)(O)O	https://pubmed.ncbi.nlm.nih.gov/19386608

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Ligand source activities (1 row/activity)