GPCRdb

Initializing potency table...

Ligand source activities (1 row/activity)

Affinity
Potency

Search:

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(+)-AJ76	322	None	18	Human	Binding	Ki	=	2331.00	5.63	-51	8	Binding affinity was measured at cloned mammalian 5-HT1A receptor expressed in CHO-K1 cells (using [3H]8-OH-DPAT )	ChEMBL	233.2	4	1	2	3.11	CCCN[C@@H]1CCc2c(OC)cccc2[C@@H]1C	https://dx.doi.org/10.1016/S0960-894X(01)80181-5
(-)-propranolol	3187	None	44	Human	Binding	pKi	None	-	5.10	-17378	34	Unclassified	Guide to Pharmacology	259.2	6	2	3	2.58	CC(C)NC[C@H](O)COc1cccc2ccccc12	https://pubmed.ncbi.nlm.nih.gov/7988681
(1R,2S)-PHENYLPROPANOLAMINE	27120	3H-LSD	13	Human	Binding	pKi	=	10000.00	5.00	-38	42	-	PDSP KiDatabase	151.1	2	2	2	1.07	C[C@H](N)[C@H](O)c1ccccc1	-
1-naphthylpiperazine	35	None	37	Human	Binding	Ki	=	40.00	7.40	-16	21	Binding affinity for rodent 5-hydroxytryptamine 5A receptor	ChEMBL	212.1	1	1	2	2.25	c1ccc2c(N3CCNCC3)cccc2c1	https://dx.doi.org/10.1021/jm030030n
1-naphthylpiperazine	35	3H-LSD	37	Mouse	Binding	pKi	=	40.00	7.40	-16	21	-	PDSP KiDatabase	212.1	1	1	2	2.25	c1ccc2c(N3CCNCC3)cccc2c1	-
1-naphthylpiperazine	35	None	37	Mouse	Binding	Ki	=	40.00	7.40	-16	21	Binding affinity towards mouse 5-hydroxytryptamine 5A receptor was evaluated using [3H]- LSD as radioligand	ChEMBL	212.1	1	1	2	2.25	c1ccc2c(N3CCNCC3)cccc2c1	https://dx.doi.org/10.1021/jm030030n
2-bromo-LSD	56	None	11	Mouse	Binding	Ki	=	2.00	8.70	5	6	Binding affinity towards mouse 5-hydroxytryptamine 5A receptor was evaluated using [125I]-2-iodo LSD as radioligand	ChEMBL	401.1	3	1	2	3.67	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]c(Br)c(c34)C[C@H]2N(C)C1	https://dx.doi.org/10.1021/jm030030n
5-CT	134	None	25	Human	Binding	pKi	None	-	7.65	-181	39	Unclassified	Guide to Pharmacology	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	https://pubmed.ncbi.nlm.nih.gov/7988681
5-CT	134	None	25	Human	Binding	pKi	None	-	7.65	-181	39	Unclassified	Guide to Pharmacology	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	https://pubmed.ncbi.nlm.nih.gov/11343685
5-CT	134	3H-5CT	25	Human	Binding	pKi	=	20.00	7.70	-181	39	-	PDSP KiDatabase	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	-
5-CT	134	None	25	Human	Binding	Ki	=	8.64	8.06	-181	39	PDSP Secondary Binding target: HTR5A - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.	ChEMBL	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	https://dx.doi.org/10.6019/CHEMBL5442175
5-CT	134	None	25	Human	Binding	Ki	=	20.00	7.70	-181	39	Binding affinity towards human 5-hydroxytryptamine 5A receptor was evaluated using [3H]-5-CT as radioligand	ChEMBL	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	https://dx.doi.org/10.1021/jm030030n
5-CT	134	None	25	Human	Binding	Ki	=	20.00	7.70	-181	39	Binding affinity towards human 5-hydroxytryptamine 5A receptor	ChEMBL	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	https://dx.doi.org/10.1021/jm030030n
5-CT	134	125I-LSD	25	Rat	Binding	pKi	=	235.50	6.63	-363	39	-	PDSP KiDatabase	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	-
5-CT	134	125I-LSD	25	Rat	Binding	pKi	=	12.58	7.90	-363	39	-	PDSP KiDatabase	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	-
5-CT	134	None	25	Rat	Binding	pKi	None	-	7.90	-363	39	Unclassified	Guide to Pharmacology	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	https://pubmed.ncbi.nlm.nih.gov/7682702
5-CT	134	None	25	Mouse	Binding	pKi	None	-	7.55	-257	39	Unclassified	Guide to Pharmacology	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	https://pubmed.ncbi.nlm.nih.gov/8450829
5-CT	134	None	25	Mouse	Binding	pKi	None	-	7.55	-257	39	Unclassified	Guide to Pharmacology	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	https://pubmed.ncbi.nlm.nih.gov/11343685
5-CT	134	None	25	Mouse	Binding	pKi	None	-	7.55	-257	39	Unclassified	Guide to Pharmacology	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	https://pubmed.ncbi.nlm.nih.gov/8549774
5-CT	134	125I-LSD	25	Mouse	Binding	pKi	=	15.84	7.80	-257	39	-	PDSP KiDatabase	203.1	3	3	2	0.77	NCCc1c[nH]c2ccc(C(N)=O)cc12	-

Showing 1 to 20 of 774 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)