Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| CHEMBL5077128 | 216971 | None | 8 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | Agonist activity at human 5-HT5A receptor transfected in HTLA cells assessed as increase in beta-arrestin 2 recruitment at 10 uM incubated for 18 to 20 hrs by bright-Glo reagent based Tango assayAgonist activity at human 5-HT5A receptor transfected in HTLA cells assessed as increase in beta-arrestin 2 recruitment at 10 uM incubated for 18 to 20 hrs by bright-Glo reagent based Tango assay |
ChEMBL | None | None | None | CS(=O)(=O)C1(CNCc2cccc3cccnc23)CC1 | 10.1021/acs.jmedchem.1c02031 | ||||
| CHEMBL5082447 | 217292 | None | 2 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | Agonist activity at human 5-HT5A receptor transfected in HTLA cells assessed as increase in beta-arrestin 2 recruitment at 10 uM incubated for 18 to 20 hrs by bright-Glo reagent based Tango assayAgonist activity at human 5-HT5A receptor transfected in HTLA cells assessed as increase in beta-arrestin 2 recruitment at 10 uM incubated for 18 to 20 hrs by bright-Glo reagent based Tango assay |
ChEMBL | None | None | None | CS(=O)(=O)C1(CNCc2ccc(Cl)c3cccnc23)CC1 | 10.1021/acs.jmedchem.1c02031 | ||||
| 785909 | 41061 | None | 4 | Human | Functional | pEC50 | = | 4.3 | 4.3 | 1 | 2 | PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905]PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] |
ChEMBL | 336 | 4 | 1 | 3 | 4.1 | COc1ccc(CN2CCc3c([nH]c4ccccc34)C2)c(OC)c1C | nan | ||
| CHEMBL1487650 | 41061 | None | 4 | Human | Functional | pEC50 | = | 4.3 | 4.3 | 1 | 2 | PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905]PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] |
ChEMBL | 336 | 4 | 1 | 3 | 4.1 | COc1ccc(CN2CCc3c([nH]c4ccccc34)C2)c(OC)c1C | nan | ||
| 1765347 | 56135 | None | 8 | Human | Functional | pEC50 | = | 4.1 | 4.1 | -1 | 2 | PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905]PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] |
ChEMBL | 324 | 7 | 2 | 3 | 3.8 | COc1ccc(CNCCc2c[nH]c3ccccc23)c(OC)c1C | nan | ||
| CHEMBL1606743 | 56135 | None | 8 | Human | Functional | pEC50 | = | 4.1 | 4.1 | -1 | 2 | PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905]PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] |
ChEMBL | 324 | 7 | 2 | 3 | 3.8 | COc1ccc(CNCCc2c[nH]c3ccccc23)c(OC)c1C | nan | ||
| CHEMBL1625496 | 56135 | None | 8 | Human | Functional | pEC50 | = | 4.1 | 4.1 | -1 | 2 | PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905]PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] |
ChEMBL | 324 | 7 | 2 | 3 | 3.8 | COc1ccc(CNCCc2c[nH]c3ccccc23)c(OC)c1C | nan | ||
| 253793 | 10559 | None | 31 | Human | Functional | pEC50 | = | 4.1 | 4.1 | -1 | 2 | PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905]PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] |
ChEMBL | 594 | 2 | 2 | 8 | 6.6 | COc1cc2c3cc1Oc1cc(ccc1O)C[C@@H]1c4c(cc(OC)c(O)c4Oc4ccc(cc4)C[C@H]3N(C)CC2)CCN1C | nan | ||
| CHEMBL1169627 | 10559 | None | 31 | Human | Functional | pEC50 | = | 4.1 | 4.1 | -1 | 2 | PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905]PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] |
ChEMBL | 594 | 2 | 2 | 8 | 6.6 | COc1cc2c3cc1Oc1cc(ccc1O)C[C@@H]1c4c(cc(OC)c(O)c4Oc4ccc(cc4)C[C@H]3N(C)CC2)CCN1C | nan | ||
| 1795 | 1591 | None | 47 | Human | Functional | pEC50 | = | 4.1 | 4.1 | -10 | 4 | PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905]PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] |
ChEMBL | 299 | 4 | 3 | 5 | 0.4 | CCN(c1nc(N)c(nc1Cl)C(=O)N=C(N)N)C(C)C | nan | ||
| 4186 | 1591 | None | 47 | Human | Functional | pEC50 | = | 4.1 | 4.1 | -10 | 4 | PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905]PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] |
ChEMBL | 299 | 4 | 3 | 5 | 0.4 | CCN(c1nc(N)c(nc1Cl)C(=O)N=C(N)N)C(C)C | nan | ||
| CHEMBL517986 | 1591 | None | 47 | Human | Functional | pEC50 | = | 4.1 | 4.1 | -10 | 4 | PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905]PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] |
ChEMBL | 299 | 4 | 3 | 5 | 0.4 | CCN(c1nc(N)c(nc1Cl)C(=O)N=C(N)N)C(C)C | nan | ||
| 16006492 | 97522 | None | 4 | Human | Functional | pKd | = | 8.5 | 8.5 | - | 0 | Antagonist activity at human recombinant 5HT5A receptor expressed in HEK293-EBNA cells by [35S]GTP-gamma-S binding assayAntagonist activity at human recombinant 5HT5A receptor expressed in HEK293-EBNA cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 195 | 0 | 2 | 3 | 2.0 | CC1NC(N)=Nc2cccc(Cl)c21 | 10.1016/j.bmcl.2007.10.080 | ||
| CHEMBL270177 | 97522 | None | 4 | Human | Functional | pKd | = | 8.5 | 8.5 | - | 0 | Antagonist activity at human recombinant 5HT5A receptor expressed in HEK293-EBNA cells by [35S]GTP-gamma-S binding assayAntagonist activity at human recombinant 5HT5A receptor expressed in HEK293-EBNA cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 195 | 0 | 2 | 3 | 2.0 | CC1NC(N)=Nc2cccc(Cl)c21 | 10.1016/j.bmcl.2007.10.080 | ||
| 16006492 | 97522 | None | 4 | Human | Functional | pKd | = | 8.5 | 8.5 | - | 0 | Antagonist activity at human 5HT5A receptor by [35S]GTP-gamma-S binding assayAntagonist activity at human 5HT5A receptor by [35S]GTP-gamma-S binding assay |
ChEMBL | 195 | 0 | 2 | 3 | 2.0 | CC1NC(N)=Nc2cccc(Cl)c21 | 10.1016/j.bmcl.2007.10.078 | ||
| CHEMBL270177 | 97522 | None | 4 | Human | Functional | pKd | = | 8.5 | 8.5 | - | 0 | Antagonist activity at human 5HT5A receptor by [35S]GTP-gamma-S binding assayAntagonist activity at human 5HT5A receptor by [35S]GTP-gamma-S binding assay |
ChEMBL | 195 | 0 | 2 | 3 | 2.0 | CC1NC(N)=Nc2cccc(Cl)c21 | 10.1016/j.bmcl.2007.10.078 | ||
| 135458393 | 155686 | None | 3 | Human | Functional | pKd | = | 7.4 | 7.4 | - | 0 | Antagonist activity at human 5HT5A receptor by [35S]GTP-gamma-S binding assayAntagonist activity at human 5HT5A receptor by [35S]GTP-gamma-S binding assay |
ChEMBL | 259 | 2 | 2 | 3 | 2.8 | CC1NC(NCC(F)F)=Nc2cccc(Cl)c21 | 10.1016/j.bmcl.2007.10.078 | ||
| CHEMBL404511 | 155686 | None | 3 | Human | Functional | pKd | = | 7.4 | 7.4 | - | 0 | Antagonist activity at human 5HT5A receptor by [35S]GTP-gamma-S binding assayAntagonist activity at human 5HT5A receptor by [35S]GTP-gamma-S binding assay |
ChEMBL | 259 | 2 | 2 | 3 | 2.8 | CC1NC(NCC(F)F)=Nc2cccc(Cl)c21 | 10.1016/j.bmcl.2007.10.078 | ||
| 135458392 | 97479 | None | 2 | Human | Functional | pKd | = | 8.1 | 8.1 | - | 0 | Antagonist activity at human recombinant 5HT5A receptor expressed in HEK293-EBNA cells by [35S]GTP-gamma-S binding assayAntagonist activity at human recombinant 5HT5A receptor expressed in HEK293-EBNA cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 209 | 0 | 2 | 3 | 2.2 | CNC1=Nc2cccc(Cl)c2C(C)N1 | 10.1016/j.bmcl.2007.10.080 | ||
| CHEMBL269964 | 97479 | None | 2 | Human | Functional | pKd | = | 8.1 | 8.1 | - | 0 | Antagonist activity at human recombinant 5HT5A receptor expressed in HEK293-EBNA cells by [35S]GTP-gamma-S binding assayAntagonist activity at human recombinant 5HT5A receptor expressed in HEK293-EBNA cells by [35S]GTP-gamma-S binding assay |
ChEMBL | 209 | 0 | 2 | 3 | 2.2 | CNC1=Nc2cccc(Cl)c2C(C)N1 | 10.1016/j.bmcl.2007.10.080 | ||
Showing 1 to 20 of 20 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 5329102 | 194838 | None | 50 | Human | Binding | pAC50 | = | 5 | 5.0 | - | 0 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | ||
| CHEMBL535 | 194838 | None | 50 | Human | Binding | pAC50 | = | 5 | 5.0 | - | 0 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | ||
| 1353 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -77 | 85 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | ||
| 3559 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -77 | 85 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | ||
| 3559.0 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -77 | 85 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | ||
| 86 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -77 | 85 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | ||
| CHEMBL54 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -77 | 85 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | ||
| DB00502 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -77 | 85 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | ||
| 1613 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.0 | 6.0 | -15 | 44 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | ||
| 205 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.0 | 6.0 | -15 | 44 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | ||
| 3964 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.0 | 6.0 | -15 | 44 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | ||
| 3964.0 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.0 | 6.0 | -15 | 44 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL831 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.0 | 6.0 | -15 | 44 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | ||
| DB00408 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.0 | 6.0 | -15 | 44 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | ||
| 3158 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.9 | 5.9 | - | 20 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | ||
| 3158.0 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.9 | 5.9 | - | 20 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1628227 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.9 | 5.9 | - | 20 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | ||
| DB01142 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.9 | 5.9 | - | 20 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | ||
| 2247 | 505 | None | 55 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 41 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1038/s41467-023-40064-9 | ||
| 249 | 505 | None | 55 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 41 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1038/s41467-023-40064-9 | ||
| 2603 | 505 | None | 55 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 41 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL296419 | 505 | None | 55 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 41 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1038/s41467-023-40064-9 | ||
| DB00637 | 505 | None | 55 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 41 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1038/s41467-023-40064-9 | ||
| 135409453 | 3773 | None | 26 | Human | Binding | pAC50 | = | 6.7 | 6.7 | -25 | 19 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | ||
| 226 | 3773 | None | 26 | Human | Binding | pAC50 | = | 6.7 | 6.7 | -25 | 19 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | ||
| CHEMBL76370 | 3773 | None | 26 | Human | Binding | pAC50 | = | 6.7 | 6.7 | -25 | 19 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | ||
| 1427 | 2013 | None | 42 | Human | Binding | pAC50 | = | 5.6 | 5.6 | - | 26 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | ||
| 357 | 2013 | None | 42 | Human | Binding | pAC50 | = | 5.6 | 5.6 | - | 26 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | ||
| 3696 | 2013 | None | 42 | Human | Binding | pAC50 | = | 5.6 | 5.6 | - | 26 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | ||
| CHEMBL11 | 2013 | None | 42 | Human | Binding | pAC50 | = | 5.6 | 5.6 | - | 26 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | ||
| DB00458 | 2013 | None | 42 | Human | Binding | pAC50 | = | 5.6 | 5.6 | - | 26 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | ||
| 135398745 | 2914 | None | 65 | Human | Binding | pAC50 | = | 5.6 | 5.6 | -109 | 65 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | ||
| 135398745.0 | 2914 | None | 65 | Human | Binding | pAC50 | = | 5.6 | 5.6 | -109 | 65 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | ||
| 47 | 2914 | None | 65 | Human | Binding | pAC50 | = | 5.6 | 5.6 | -109 | 65 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | ||
| CHEMBL715 | 2914 | None | 65 | Human | Binding | pAC50 | = | 5.6 | 5.6 | -109 | 65 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | ||
| DB00334 | 2914 | None | 65 | Human | Binding | pAC50 | = | 5.6 | 5.6 | -109 | 65 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | ||
| 1400 | 1957 | None | 46 | Human | Binding | pAC50 | = | 6.6 | 6.6 | - | 3 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 3658 | 1957 | None | 46 | Human | Binding | pAC50 | = | 6.6 | 6.6 | - | 3 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 3658.0 | 1957 | None | 46 | Human | Binding | pAC50 | = | 6.6 | 6.6 | - | 3 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 7199 | 1957 | None | 46 | Human | Binding | pAC50 | = | 6.6 | 6.6 | - | 3 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 91513 | 1957 | None | 46 | Human | Binding | pAC50 | = | 6.6 | 6.6 | - | 3 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL896 | 1957 | None | 46 | Human | Binding | pAC50 | = | 6.6 | 6.6 | - | 3 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| DB00557 | 1957 | None | 46 | Human | Binding | pAC50 | = | 6.6 | 6.6 | - | 3 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 2726 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -16 | 72 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | ||
| 2726.0 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -16 | 72 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | ||
| 621 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -16 | 72 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | ||
| 83 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -16 | 72 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | ||
| CHEMBL71 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -16 | 72 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | ||
| DB00477 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -16 | 72 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | ||
| 43815 | 187026 | None | 38 | Human | Binding | pAC50 | = | 5.3 | 5.3 | - | 24 | Binding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR5A in an in vitro assay with cellular components measured by membrane filtration |
ChEMBL | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | 10.1038/s41467-023-40064-9 | ||
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