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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	10883396	3649	None	30	Human	Functional	pEC50	=	8.9	8.9	-2	15	Agonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/ml400194r
	5283560	3649	None	30	Human	Functional	pEC50	=	8.9	8.9	-2	15	Agonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/ml400194r
	911	3649	None	30	Human	Functional	pEC50	=	8.9	8.9	-2	15	Agonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/ml400194r
	CHEMBL225155	3649	None	30	Human	Functional	pEC50	=	8.9	8.9	-2	15	Agonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/ml400194r
	9593133	109172	None	5	Human	Functional	pEC50	=	5.0	5.0	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	468	6	1	9	3.5	Clc1ccc(-c2ccc(/C=N/Nc3cc(N4CCOCC4)nc(N4CCOCC4)n3)o2)cc1	nan
	CHEMBL3213728	109172	None	5	Human	Functional	pEC50	=	5.0	5.0	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	468	6	1	9	3.5	Clc1ccc(-c2ccc(/C=N/Nc3cc(N4CCOCC4)nc(N4CCOCC4)n3)o2)cc1	nan
	58344778	154627	None	0	Human	Functional	pEC50	=	6.0	6.0	-6309	5	Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs	ChEMBL	360	4	1	6	4.0	CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N	nan
	CHEMBL3902160	154627	None	0	Human	Functional	pEC50	=	6.0	6.0	-6309	5	Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs	ChEMBL	360	4	1	6	4.0	CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N	nan
	CHEMBL3990889	154627	None	0	Human	Functional	pEC50	=	6.0	6.0	-6309	5	Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs	ChEMBL	360	4	1	6	4.0	CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N	nan
	2113511	31627	None	27	Human	Functional	pEC50	=	5.9	5.9	10	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]	ChEMBL	324	5	0	4	2.5	Cc1cc(C(=O)CN2C(=O)CCC2=O)c(C)n1Cc1ccccc1	nan
	CHEMBL1404553	31627	None	27	Human	Functional	pEC50	=	5.9	5.9	10	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]	ChEMBL	324	5	0	4	2.5	Cc1cc(C(=O)CN2C(=O)CCC2=O)c(C)n1Cc1ccccc1	nan
	977094	22848	None	6	Human	Functional	pEC50	=	5.9	5.9	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	284	2	0	4	2.1	COc1cc2c(cc1OC)C1=C(C#N)CCC(=O)N1CC2	nan
	CHEMBL1328358	22848	None	6	Human	Functional	pEC50	=	5.9	5.9	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	284	2	0	4	2.1	COc1cc2c(cc1OC)C1=C(C#N)CCC(=O)N1CC2	nan
	658787	46700	None	25	Human	Functional	pEC50	=	5.9	5.9	9	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	324	2	1	4	3.4	Clc1ccc2nc(N3CCNCC3)nc(-c3ccccc3)c2c1	nan
	CHEMBL1539075	46700	None	25	Human	Functional	pEC50	=	5.9	5.9	9	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	324	2	1	4	3.4	Clc1ccc2nc(N3CCNCC3)nc(-c3ccccc3)c2c1	nan
	10883396	3649	None	30	Human	Functional	pEC50	=	7.8	7.8	-2	15	Agonist activity at S1P2 (unknown origin) expressed in CHO cells assessed as Ca2+ activationAgonist activity at S1P2 (unknown origin) expressed in CHO cells assessed as Ca2+ activation	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/acs.jmedchem.3c00498
	5283560	3649	None	30	Human	Functional	pEC50	=	7.8	7.8	-2	15	Agonist activity at S1P2 (unknown origin) expressed in CHO cells assessed as Ca2+ activationAgonist activity at S1P2 (unknown origin) expressed in CHO cells assessed as Ca2+ activation	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/acs.jmedchem.3c00498
	911	3649	None	30	Human	Functional	pEC50	=	7.8	7.8	-2	15	Agonist activity at S1P2 (unknown origin) expressed in CHO cells assessed as Ca2+ activationAgonist activity at S1P2 (unknown origin) expressed in CHO cells assessed as Ca2+ activation	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/acs.jmedchem.3c00498
	CHEMBL225155	3649	None	30	Human	Functional	pEC50	=	7.8	7.8	-2	15	Agonist activity at S1P2 (unknown origin) expressed in CHO cells assessed as Ca2+ activationAgonist activity at S1P2 (unknown origin) expressed in CHO cells assessed as Ca2+ activation	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/acs.jmedchem.3c00498
	67194420	143099	None	0	Human	Functional	pEC50	=	5.8	5.8	-31622	4	Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs	ChEMBL	468	8	2	8	3.0	CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NS(=O)(=O)CCO)no2)cc1C#N	nan
	CHEMBL3894716	143099	None	0	Human	Functional	pEC50	=	5.8	5.8	-31622	4	Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs	ChEMBL	468	8	2	8	3.0	CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NS(=O)(=O)CCO)no2)cc1C#N	nan
	2056575	108786	None	5	Human	Functional	pEC50	=	5.8	5.8	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	421	3	0	4	4.5	COc1cc2c(cc1OC)C1=C(C#N)CC/C(=N\C(=O)c3ccc(Cl)cc3)N1CC2	nan
	CHEMBL3208498	108786	None	5	Human	Functional	pEC50	=	5.8	5.8	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	421	3	0	4	4.5	COc1cc2c(cc1OC)C1=C(C#N)CC/C(=N\C(=O)c3ccc(Cl)cc3)N1CC2	nan
	1891819	36500	None	5	Human	Functional	pEC50	=	5.8	5.8	7	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	431	6	2	7	3.7	CC(C)CCNC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12	nan
	CHEMBL1447632	36500	None	5	Human	Functional	pEC50	=	5.8	5.8	7	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	431	6	2	7	3.7	CC(C)CCNC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12	nan
	3093171	46092	None	10	Human	Functional	pEC50	=	5.7	5.7	1	4	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	423	8	2	6	1.9	O=S(=O)(c1ccc(N2CCC(c3ccc(Cl)cc3)=N2)cc1)N(CCO)CCO	nan
	CHEMBL1533401	46092	None	10	Human	Functional	pEC50	=	5.7	5.7	1	4	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	423	8	2	6	1.9	O=S(=O)(c1ccc(N2CCC(c3ccc(Cl)cc3)=N2)cc1)N(CCO)CCO	nan
	733831	32250	None	7	Human	Functional	pEC50	=	5.7	5.7	-2	3	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	328	4	0	7	2.8	CCOC(=O)c1cc2ccc(OC(=O)c3ccco3)cc2oc1=O	nan
	CHEMBL1409828	32250	None	7	Human	Functional	pEC50	=	5.7	5.7	-2	3	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	328	4	0	7	2.8	CCOC(=O)c1cc2ccc(OC(=O)c3ccco3)cc2oc1=O	nan
	4669891	51824	None	13	Human	Functional	pEC50	=	5.7	5.7	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	386	3	0	4	5.5	O=c1c(-c2nc3ccccc3s2)cccn1Cc1ccc(Cl)c(Cl)c1	nan
	CHEMBL1585097	51824	None	13	Human	Functional	pEC50	=	5.7	5.7	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	386	3	0	4	5.5	O=c1c(-c2nc3ccccc3s2)cccn1Cc1ccc(Cl)c(Cl)c1	nan
	2016176	42477	None	5	Human	Functional	pEC50	=	5.7	5.7	9	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	441	7	2	6	4.6	Nc1c(C(=O)NCCCc2ccccc2)c2nc3ccccc3nc2n1Cc1cccs1	nan
	CHEMBL1499346	42477	None	5	Human	Functional	pEC50	=	5.7	5.7	9	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	441	7	2	6	4.6	Nc1c(C(=O)NCCCc2ccccc2)c2nc3ccccc3nc2n1Cc1cccs1	nan
	7756956	39656	None	3	Human	Functional	pEC50	=	4.7	4.7	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]	ChEMBL	353	5	0	5	1.8	Cc1cc(C(=O)CN2C(=O)C(=O)N(C)C2=O)c(C)n1Cc1ccccc1	nan
	CHEMBL1474501	39656	None	3	Human	Functional	pEC50	=	4.7	4.7	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]	ChEMBL	353	5	0	5	1.8	Cc1cc(C(=O)CN2C(=O)C(=O)N(C)C2=O)c(C)n1Cc1ccccc1	nan
	662039	20274	None	5	Human	Functional	pEC50	=	5.6	5.6	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	417	5	2	7	3.5	CCC(C)NC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12	nan
	CHEMBL1305537	20274	None	5	Human	Functional	pEC50	=	5.6	5.6	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	417	5	2	7	3.5	CCC(C)NC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12	nan
	3800606	34929	None	5	Human	Functional	pEC50	=	5.6	5.6	1	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	417	5	2	7	3.3	CC(C)CNC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12	nan
	CHEMBL1432243	34929	None	5	Human	Functional	pEC50	=	5.6	5.6	1	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	417	5	2	7	3.3	CC(C)CNC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12	nan
	44422601	85615	None	0	Human	Functional	pEC50	=	6.6	6.6	-74	5	Activity at human S1P2 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P2 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay	ChEMBL	398	14	4	3	4.2	CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1	10.1016/j.bmc.2006.10.060
	CHEMBL228139	85615	None	0	Human	Functional	pEC50	=	6.6	6.6	-74	5	Activity at human S1P2 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P2 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay	ChEMBL	398	14	4	3	4.2	CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1	10.1016/j.bmc.2006.10.060
	2842931	46566	None	11	Human	Functional	pEC50	=	5.6	5.6	2	3	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	328	3	0	4	5.4	Clc1ccc(N2N=C(c3cccs3)CC2c2ccco2)cc1	nan
	CHEMBL1537907	46566	None	11	Human	Functional	pEC50	=	5.6	5.6	2	3	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	328	3	0	4	5.4	Clc1ccc(N2N=C(c3cccs3)CC2c2ccco2)cc1	nan
	2113511	31627	None	27	Human	Functional	pEC50	=	5.5	5.5	10	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	324	5	0	4	2.5	Cc1cc(C(=O)CN2C(=O)CCC2=O)c(C)n1Cc1ccccc1	nan
	CHEMBL1404553	31627	None	27	Human	Functional	pEC50	=	5.5	5.5	10	2	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	324	5	0	4	2.5	Cc1cc(C(=O)CN2C(=O)CCC2=O)c(C)n1Cc1ccccc1	nan
	1472014	20640	None	8	Human	Functional	pEC50	=	5.5	5.5	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	352	3	0	4	4.8	O=c1c(-c2nc3ccccc3s2)cccn1Cc1ccc(Cl)cc1	nan
	CHEMBL1308408	20640	None	8	Human	Functional	pEC50	=	5.5	5.5	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor. (Class of assay: confirmatory) [Related pubchem assays: 729, 736, 843 ]	ChEMBL	352	3	0	4	4.8	O=c1c(-c2nc3ccccc3s2)cccn1Cc1ccc(Cl)cc1	nan
	2460650	22810	None	14	Human	Functional	pEC50	=	4.5	4.5	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]	ChEMBL	341	6	0	7	2.7	Cc1cc(C(=O)CSc2nnnn2C)c(C)n1Cc1ccccc1	nan
	CHEMBL1328093	22810	None	14	Human	Functional	pEC50	=	4.5	4.5	-	1	PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Receptor of Purchased Analogues. (Class of assay: confirmatory) [Related pubchem assays: 729, 843, 854, 736 ]	ChEMBL	341	6	0	7	2.7	Cc1cc(C(=O)CSc2nnnn2C)c(C)n1Cc1ccccc1	nan
	10883396	3649	None	30	Human	Functional	pEC50	=	7.5	7.5	-2	15	Agonist activity at S1P2 (unknown origin) expressed in PathHunter CHO-K1 EDG1 beta-arrestin cells assessed as beta-arrestin recruitmentAgonist activity at S1P2 (unknown origin) expressed in PathHunter CHO-K1 EDG1 beta-arrestin cells assessed as beta-arrestin recruitment	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/acs.jmedchem.3c00498

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	10883396	3649	None	30	Human	Binding	pEC50	=	9.2	9.2	-11	4	Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/jm100181s
	5283560	3649	None	30	Human	Binding	pEC50	=	9.2	9.2	-11	4	Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/jm100181s
	911	3649	None	30	Human	Binding	pEC50	=	9.2	9.2	-11	4	Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/jm100181s
	CHEMBL225155	3649	None	30	Human	Binding	pEC50	=	9.2	9.2	-11	4	Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/jm100181s
	49839234	118015	None	0	Human	Binding	pEC50	=	5	5.0	-	0	Agonist activity at human S1P2 receptor by beta-arrestin recruitment assayAgonist activity at human S1P2 receptor by beta-arrestin recruitment assay	ChEMBL	472	6	3	3	6.1	O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21	10.1016/j.bmcl.2014.11.089
	CHEMBL3403619	118015	None	0	Human	Binding	pEC50	=	5	5.0	-	0	Agonist activity at human S1P2 receptor by beta-arrestin recruitment assayAgonist activity at human S1P2 receptor by beta-arrestin recruitment assay	ChEMBL	472	6	3	3	6.1	O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21	10.1016/j.bmcl.2014.11.089
	44398076	12905	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay	ChEMBL	425	13	5	5	3.2	CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1	10.1016/j.bmcl.2005.05.097
	CHEMBL1188968	12905	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay	ChEMBL	425	13	5	5	3.2	CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1	10.1016/j.bmcl.2005.05.097
	CHEMBL537849	12905	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay	ChEMBL	425	13	5	5	3.2	CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1	10.1016/j.bmcl.2005.05.097
	10883396	3649	None	30	Human	Binding	pEC50	=	8.7	8.7	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2004.07.030
	5283560	3649	None	30	Human	Binding	pEC50	=	8.7	8.7	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2004.07.030
	911	3649	None	30	Human	Binding	pEC50	=	8.7	8.7	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2004.07.030
	CHEMBL225155	3649	None	30	Human	Binding	pEC50	=	8.7	8.7	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2004.07.030
	10883396	3649	None	30	Human	Binding	pEC50	=	8.5	8.5	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/s0960-894x(03)00812-6
	5283560	3649	None	30	Human	Binding	pEC50	=	8.5	8.5	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/s0960-894x(03)00812-6
	911	3649	None	30	Human	Binding	pEC50	=	8.5	8.5	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/s0960-894x(03)00812-6
	CHEMBL225155	3649	None	30	Human	Binding	pEC50	=	8.5	8.5	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/s0960-894x(03)00812-6
	44392705	66687	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	380	17	4	4	3.2	CCCCCCCCCCCCCCNC(=O)[C@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	9821227	66687	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	380	17	4	4	3.2	CCCCCCCCCCCCCCNC(=O)[C@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	CHEMBL185389	66687	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	380	17	4	4	3.2	CCCCCCCCCCCCCCNC(=O)[C@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	CHEMBL332472	66687	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	380	17	4	4	3.2	CCCCCCCCCCCCCCNC(=O)[C@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	44342244	64897	None	2	Human	Binding	pEC50	=	5.6	5.6	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	380	17	4	4	3.2	CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	CHEMBL182164	64897	None	2	Human	Binding	pEC50	=	5.6	5.6	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	380	17	4	4	3.2	CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	CHEMBL423691	64897	None	2	Human	Binding	pEC50	=	5.6	5.6	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	380	17	4	4	3.2	CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	44342246	11416	None	0	Human	Binding	pEC50	=	5.6	5.6	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	396	18	4	5	3.2	CCCCCCCCCCCCCCONC(=O)[C@@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	CHEMBL115505	11416	None	0	Human	Binding	pEC50	=	5.6	5.6	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	396	18	4	5	3.2	CCCCCCCCCCCCCCONC(=O)[C@@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	CHEMBL1180159	11416	None	0	Human	Binding	pEC50	=	5.6	5.6	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	396	18	4	5	3.2	CCCCCCCCCCCCCCONC(=O)[C@@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	10883396	3649	None	30	Human	Binding	pEC50	=	8.1	8.1	-11	4	Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2005.05.097
	5283560	3649	None	30	Human	Binding	pEC50	=	8.1	8.1	-11	4	Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2005.05.097
	911	3649	None	30	Human	Binding	pEC50	=	8.1	8.1	-11	4	Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2005.05.097
	CHEMBL225155	3649	None	30	Human	Binding	pEC50	=	8.1	8.1	-11	4	Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2005.05.097
	10883396	3649	None	30	Human	Binding	pEC50	=	8.1	8.1	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/s0960-894x(03)00812-6
	5283560	3649	None	30	Human	Binding	pEC50	=	8.1	8.1	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/s0960-894x(03)00812-6
	911	3649	None	30	Human	Binding	pEC50	=	8.1	8.1	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/s0960-894x(03)00812-6
	CHEMBL225155	3649	None	30	Human	Binding	pEC50	=	8.1	8.1	-11	4	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/s0960-894x(03)00812-6
	44342221	12097	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	352	15	4	4	2.5	CCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	CHEMBL1183918	12097	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	352	15	4	4	2.5	CCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	CHEMBL324358	12097	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand	ChEMBL	352	15	4	4	2.5	CCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O	10.1016/s0960-894x(03)00812-6
	10883396	3649	None	30	Human	Binding	pIC50	=	9.6	9.6	-11	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2004.02.106
	5283560	3649	None	30	Human	Binding	pIC50	=	9.6	9.6	-11	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2004.02.106
	911	3649	None	30	Human	Binding	pIC50	=	9.6	9.6	-11	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2004.02.106
	CHEMBL225155	3649	None	30	Human	Binding	pIC50	=	9.6	9.6	-11	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1016/j.bmcl.2004.02.106
	10883396	3649	None	30	Human	Binding	pIC50	=	9.5	9.5	-11	4	Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/jm0492507
	5283560	3649	None	30	Human	Binding	pIC50	=	9.5	9.5	-11	4	Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/jm0492507
	911	3649	None	30	Human	Binding	pIC50	=	9.5	9.5	-11	4	Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/jm0492507
	CHEMBL225155	3649	None	30	Human	Binding	pIC50	=	9.5	9.5	-11	4	Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells	ChEMBL	379	17	4	4	4.0	CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O	10.1021/jm0492507
	11725751	12851	None	3	Human	Binding	pIC50	=	9.2	9.2	-	0	Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand	ChEMBL	355	14	3	2	4.6	CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1	10.1016/j.bmcl.2004.04.069
	11725751	12851	None	3	Human	Binding	pIC50	=	9.2	9.2	-	0	Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand	ChEMBL	355	14	3	2	4.6	CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1	10.1016/j.bmcl.2004.04.070
	CHEMBL118860	12851	None	3	Human	Binding	pIC50	=	9.2	9.2	-	0	Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand	ChEMBL	355	14	3	2	4.6	CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1	10.1016/j.bmcl.2004.04.069
	CHEMBL118860	12851	None	3	Human	Binding	pIC50	=	9.2	9.2	-	0	Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand	ChEMBL	355	14	3	2	4.6	CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1	10.1016/j.bmcl.2004.04.070

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Ligand source activities (1 row/activity)