GPCRdb

Finalizing display...

Ligand source activities (1 row/activity)

Affinity
Potency

Search:

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

AZD3778	547	None	6	Human	Binding	pKi	=	-	8.20	1	2	Assay using sodium salt of the compound	Guide to Pharmacology	525.1	5	1	5	4.71	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	https://pubmed.ncbi.nlm.nih.gov/23031591
AZD3778	547	None	6	Human	Binding	IC50	=	8.10	8.09	1	2	Antagonist activity at CCR3 assessed as inhibition of eotaxin binding	ChEMBL	525.1	5	1	5	4.71	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	https://dx.doi.org/10.1021/jm300682j
AZD3778	547	None	6	Human	Binding	Ki	=	6.31	8.20	1	2	Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay	ChEMBL	525.1	5	1	5	4.71	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	https://dx.doi.org/10.1016/j.bmcl.2012.08.124
AZD3778	547	None	6	Human	Binding	Ki	=	6.31	8.20	1	2	Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay	ChEMBL	525.1	5	1	5	4.71	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	https://dx.doi.org/10.1016/j.bmcl.2012.08.103
banyu (I)	574	None	5	Human	Binding	pKi	=	-	8.50	-	2	Unclassified	Guide to Pharmacology	480.1	6	2	6	5.06	Nc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1	https://pubmed.ncbi.nlm.nih.gov/12450563
banyu (I)	574	None	5	Human	Binding	pKd	None	-	8.30	-	2	Unclassified	Guide to Pharmacology	480.1	6	2	6	5.06	Nc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1	https://pubmed.ncbi.nlm.nih.gov/12450563
banyu (I)	574	None	5	Human	Binding	IC50	=	2.30	8.64	-	2	Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells	ChEMBL	480.1	6	2	6	5.06	Nc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1	https://dx.doi.org/10.1016/s0960-894x(01)00176-7
banyu (I)	574	None	5	Human	Binding	IC50	=	2.30	8.64	-	2	Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand	ChEMBL	480.1	6	2	6	5.06	Nc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1	https://dx.doi.org/10.1016/s0960-894x(03)00748-0
BERLEX COMPOUND	118652	None	11	Human	Binding	IC50	=	9000.00	5.05	-	4	Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells	ChEMBL	444.2	7	1	3	5.91	N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1	https://dx.doi.org/10.1021/jm0201767
BMS compound 87b	692	None	0	Human	Binding	pKi	=	-	8.10	-	1	Unclassified	Guide to Pharmacology	451.3	10	3	4	4.50	CC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1	https://pubmed.ncbi.nlm.nih.gov/12067561
BMS compound 87b	692	None	0	Human	Binding	IC50	=	6.00	8.22	-	1	In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin	ChEMBL	451.3	10	3	4	4.50	CC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1	https://dx.doi.org/10.1016/s0960-894x(02)00206-8
BMS compound 87b	692	None	0	Human	Binding	IC50	=	8.00	8.10	-	1	In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin	ChEMBL	451.3	10	3	4	4.50	CC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1	https://dx.doi.org/10.1016/s0960-894x(02)00206-8
CCL11	826	None	0	Human	Binding	pKi	=	-	9.75	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8642344
CCL11	827	None	0	Human	Binding	pKi	=	-	9.85	446	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8642344
CCL2	838	None	0	Human	Binding	pKi	None	-	7.50	1	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8642344
CCL5	865	None	0	Human	Binding	pKi	=	-	8.90	-3	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8642344
CCL7	866	None	0	Human	Binding	pKi	=	-	8.90	6	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8642344
cenicriviroc	879	None	32	Human	Binding	IC50	=	2400.00	5.62	-	6	Displacement of [125I]eotaxin from CCR3 expressed in CHO cells	ChEMBL	696.4	17	1	7	8.74	CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S@@](=O)Cc4cncn4CCC)cc2)CCCN3CC(C)C)cc1	https://dx.doi.org/10.1021/jm0509703
CHEMBL1180359	11460	None	0	Human	Binding	IC50	=	11.00	7.96	-	1	Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells	ChEMBL	483.2	6	2	4	5.53	C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccccc2)CC1	https://dx.doi.org/10.1021/jm0201767
CHEMBL1180385	11474	None	0	Human	Binding	IC50	=	2.00	8.70	-	1	Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells	ChEMBL	501.2	6	2	4	5.67	C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccc(F)cc2)CC1	https://dx.doi.org/10.1021/jm0201767

Showing 1 to 20 of 1,100 entries

Search:

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

AZD3778	547	None	6	Human	Functional	Kd	=	100.00	7.00	4	2	Antagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysis	ChEMBL	525.1	5	1	5	4.71	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	https://dx.doi.org/10.1016/j.bmcl.2012.08.124
BMS compound 87b	692	None	0	Human	Functional	IC50	=	20.00	7.70	-	1	In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay	ChEMBL	451.3	10	3	4	4.50	CC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1	https://dx.doi.org/10.1016/s0960-894x(02)00206-8
CCL11	827	None	0	Human	Functional	pIC50	=	-	8.85	14	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9276730
CCL11	827	None	0	Human	Functional	pIC50	=	-	8.85	14	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10488147
CCL11	827	None	0	Human	Functional	pIC50	=	-	8.85	14	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/16339911
CCL11	827	None	0	Human	Functional	pIC50	=	-	8.85	14	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12761559
CCL11	827	None	0	Human	Functional	pIC50	=	-	8.85	14	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10854442
CCL13	828	None	0	Human	Functional	pIC50	=	-	9.50	7	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9276730
CCL13	828	None	0	Human	Functional	pIC50	=	-	9.50	7	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/16339911
CCL15	830	None	0	Human	Functional	pIC50	=	-	8.60	5	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9346309
CCL18	833	None	0	Human	Functional	pIC50	=	-	7.50	25	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/23951310
CCL24	849	None	0	Human	Functional	pIC50	=	-	8.70	316	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/15207250
CCL24	849	None	0	Human	Functional	pIC50	=	-	8.70	316	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/16339911
CCL26	853	None	0	Human	Functional	pIC50	=	-	8.40	-1	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/15207250
CCL26	853	None	0	Human	Functional	pIC50	=	-	8.40	-1	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10488147
CCL26	853	None	0	Human	Functional	pIC50	=	-	8.40	-1	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/16339911
CHEMBL123611	16507	None	0	Human	Functional	IC50	=	30.00	7.52	-	1	Inhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	516.3	8	3	4	5.49	CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1	https://dx.doi.org/10.1021/jm049530m
CHEMBL175634	60526	None	0	Human	Functional	IC50	=	10.00	8.00	-	1	Inhibition of calcium mobilization in human eosinophils	ChEMBL	453.3	7	2	3	5.47	COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1	https://dx.doi.org/10.1021/jm049530m
CHEMBL175634	60526	None	0	Human	Functional	IC50	=	115.00	6.94	-	1	Inhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	453.3	7	2	3	5.47	COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1	https://dx.doi.org/10.1021/jm049530m
CHEMBL178019	62507	None	0	Human	Functional	IC50	=	350.00	6.46	-	1	Antagonist activity against C-C chemokine receptor type 3	ChEMBL	461.2	9	2	6	3.28	C=C(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OCC	https://dx.doi.org/10.1016/s0960-894x(01)00249-9

Showing 1 to 20 of 327 entries

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)