Initializing potency table...
Ligand source activities (1 row/activity)
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
| α-methyl-5-HT | 364 | None | 24 | Human | Binding | pKi | None | - | 5.80 | -208 | 19 | Unclassified | Guide to Pharmacology | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | https://pubmed.ncbi.nlm.nih.gov/15466450 | |
| α-methyl-5-HT | 364 | None | 24 | Human | Binding | pKi | None | - | 5.80 | -208 | 19 | Unclassified | Guide to Pharmacology | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | https://pubmed.ncbi.nlm.nih.gov/7796807 | |
| α-methyl-5-HT | 364 | 3H-GR-113808 | 24 | Guinea pig | Binding | pKi | = | 1584.89 | 5.80 | -208 | 19 | - | PDSP KiDatabase | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | - | |
| α-methyl-5-HT | 364 | 3H-GR-113808 | 24 | Guinea pig | Binding | pKi | = | 1584.89 | 5.80 | -208 | 19 | - | PDSP KiDatabase | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | - | |
| α-methyl-5-HT | 364 | 3H-GR-113808 | 24 | Guinea pig | Binding | pKi | = | 1584.89 | 5.80 | -208 | 19 | - | PDSP KiDatabase | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | - | |
| α-methyl-5-HT | 364 | 3H-GR-113808 | 24 | Guinea pig | Binding | pKi | = | 1584.89 | 5.80 | -208 | 19 | - | PDSP KiDatabase | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | - | |
| α-methyl-5-HT | 364 | 3H-GR-113808 | 24 | Rat | Binding | pKi | = | 1450.00 | 5.84 | -89 | 19 | - | PDSP KiDatabase | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | - | |
| α-methyl-5-HT | 364 | 3H-GR-113808 | 24 | Rat | Binding | pKi | = | 1450.00 | 5.84 | -89 | 19 | - | PDSP KiDatabase | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | - | |
| α-methyl-5-HT | 364 | 3H-5HT | 24 | Rat | Binding | pKi | = | 263.00 | 6.58 | -89 | 19 | - | PDSP KiDatabase | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | - | |
| α-methyl-5-HT | 364 | None | 24 | Rat | Binding | pKi | None | - | 6.10 | -89 | 19 | Unclassified | Guide to Pharmacology | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | https://pubmed.ncbi.nlm.nih.gov/8813606 | |
| α-methyl-5-HT | 364 | None | 24 | Rat | Binding | pKi | None | - | 6.10 | -89 | 19 | Unclassified | Guide to Pharmacology | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | https://pubmed.ncbi.nlm.nih.gov/9225293 | |
| (R)ZACOPRIDE | 98858 | None | 2 | Rat | Binding | Ki | = | 1510.00 | 5.82 | - | 1 | Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand | ChEMBL | 309.1 | 3 | 2 | 4 | 1.75 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | https://dx.doi.org/10.1021/jm960320m | |
| (R)ZACOPRIDE | 98858 | None | 2 | Rat | Binding | ED50 | = | 505.00 | 6.30 | - | 1 | Relaxation of carbachol induced contractions of rat tunica muscularis mucosae | ChEMBL | 309.1 | 3 | 2 | 4 | 1.75 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | https://dx.doi.org/10.1021/jm00086a019 | |
| 5-CT | 134 | 3H-GR-113808 | 25 | Human | Binding | pKi | = | 10000.00 | 5.00 | -109647 | 39 | - | PDSP KiDatabase | 203.1 | 3 | 3 | 2 | 0.77 | NCCc1c[nH]c2ccc(C(N)=O)cc12 | - | |
| 5-CT | 134 | 3H-GR-113808 | 25 | Guinea pig | Binding | pKi | = | 10000.00 | 5.00 | -87096 | 39 | - | PDSP KiDatabase | 203.1 | 3 | 3 | 2 | 0.77 | NCCc1c[nH]c2ccc(C(N)=O)cc12 | - | |
| 5-CT | 134 | 3H-GR-113808 | 25 | Guinea pig | Binding | pKi | = | 6309.57 | 5.20 | -87096 | 39 | - | PDSP KiDatabase | 203.1 | 3 | 3 | 2 | 0.77 | NCCc1c[nH]c2ccc(C(N)=O)cc12 | - | |
| 5-CT | 134 | 3H-GR-113808 | 25 | Guinea pig | Binding | pKi | = | 10000.00 | 5.00 | -87096 | 39 | - | PDSP KiDatabase | 203.1 | 3 | 3 | 2 | 0.77 | NCCc1c[nH]c2ccc(C(N)=O)cc12 | - | |
| 5-CT | 134 | 3H-GR-113808 | 25 | Guinea pig | Binding | pKi | = | 6309.57 | 5.20 | -87096 | 39 | - | PDSP KiDatabase | 203.1 | 3 | 3 | 2 | 0.77 | NCCc1c[nH]c2ccc(C(N)=O)cc12 | - | |
| 5-CT | 134 | 3H-GR-113808 | 25 | Rat | Binding | pKi | = | 3162.27 | 5.50 | -46773 | 39 | - | PDSP KiDatabase | 203.1 | 3 | 3 | 2 | 0.77 | NCCc1c[nH]c2ccc(C(N)=O)cc12 | - | |
| 5-CT | 134 | 3H-RS 57639 | 25 | Rat | Binding | pKi | = | 5011.87 | 5.30 | -46773 | 39 | - | PDSP KiDatabase | 203.1 | 3 | 3 | 2 | 0.77 | NCCc1c[nH]c2ccc(C(N)=O)cc12 | - | |
Showing 1 to 20 of 1,323 entries
| Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Common name |
GPCRdb ID |
Reference ligand |
Vendors | Species | Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI | |