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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(S)-FTY720-phosphate	3596	None	37	Human	Binding	EC50	=	5.01	8.30	-	6	Agonist activity at human S1P3 receptor expressed in RBL cells by [35S]GTP-gammaS accumulation assay	ChEMBL	387.2	14	4	4	3.32	CCCCCCCCc1ccc(CC[C@](N)(CO)COP(=O)(O)O)cc1	https://dx.doi.org/10.1021/acs.jmedchem.5b01512
(S)-FTY720-phosphate	3596	None	37	Human	Binding	EC50	=	94.00	7.03	-	6	Agonist activity at human S1P3 receptor expressed in EDG3-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay	ChEMBL	387.2	14	4	4	3.32	CCCCCCCCc1ccc(CC[C@](N)(CO)COP(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2015.11.090
(S)-FTY720-phosphate	3596	None	37	Human	Binding	IC50	=	6.30	8.20	-	6	Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranes	ChEMBL	387.2	14	4	4	3.32	CCCCCCCCc1ccc(CC[C@](N)(CO)COP(=O)(O)O)cc1	https://dx.doi.org/10.1021/ml100227q
BMS-986104	140397	None	11	Human	Binding	EC50	=	2065.00	5.68	-	1	Agonist activity at human S1P3 expressed in EDG3-Ga15-bla HEK293T cells incubated for 45 mins by scintillation counting based [35S]GTP-gamma-S binding assay relative to control	ChEMBL	329.3	7	2	2	4.72	CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(CO)C3)ccc2C1	https://dx.doi.org/10.1021/acs.jmedchem.6b01433
CHEMBL1088819	7703	None	0	Human	Binding	IC50	=	2000.00	5.70	-	2	Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	495.2	10	4	6	3.61	C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(C#N)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1088820	7704	None	0	Human	Binding	IC50	=	285.00	6.54	-	2	Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	504.1	10	4	5	4.39	C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(Cl)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1089127	7763	None	0	Human	Binding	IC50	=	1000.00	6.00	-	2	Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	548.1	10	4	5	4.50	C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(Br)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1090796	8023	None	0	Human	Binding	IC50	=	3800.00	5.42	-	4	Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	482.2	10	4	5	3.93	C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(C(=O)CCc2ccc(-c3ccccc3)cc2)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1090828	8032	None	0	Human	Binding	IC50	=	700.00	6.16	-	2	Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	538.1	10	4	5	4.76	C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1C(F)(F)F	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1093424	8412	None	0	Human	Binding	IC50	=	3250.00	5.49	-	2	Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	484.2	10	4	5	4.05	Cc1cc(NC(=O)[C@@](C)(N)COP(=O)(O)O)ccc1OCCc1ccc(-c2ccccc2)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1093429	8413	None	0	Human	Binding	IC50	=	4500.00	5.35	-	4	Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	538.1	10	4	5	4.76	C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(C(F)(F)F)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1093823	8466	None	0	Human	Binding	IC50	=	2000.00	5.70	-	4	Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	547.1	9	4	5	5.63	C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1095833	8719	None	24	Human	Binding	IC50	=	2068.00	5.68	-	4	Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting	ChEMBL	460.1	8	2	6	4.27	CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C	https://dx.doi.org/10.1021/jm100181s
CHEMBL112655	9627	None	0	Human	Binding	IC50	=	68.00	7.17	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranes	ChEMBL	371.2	13	4	3	3.39	CCCCCCCCc1ccc(CCC(N)C(O)CP(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL113344	9736	None	0	Human	Binding	IC50	=	62.00	7.21	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranes	ChEMBL	371.2	13	4	3	3.74	CCCCCCCCc1ccc(CCC(N)CC(O)P(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL114584	9939	None	2	Human	Binding	IC50	=	510.00	6.29	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranes	ChEMBL	385.2	14	4	3	3.78	CCCCCCCCc1ccc(CCC(N)(CO)CCP(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL114584	9939	None	2	Human	Binding	IC50	=	7.00	8.15	-	4	Displacement of [33P]-S1P from S1P3 receptor (unknown origin) expressed in CHO cell membranes	ChEMBL	385.2	14	4	3	3.78	CCCCCCCCc1ccc(CCC(N)(CO)CCP(=O)(O)O)cc1	https://dx.doi.org/10.1021/acs.jmedchem.6b01575
CHEMBL114976	10016	None	0	Human	Binding	IC50	=	320.00	6.50	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranes	ChEMBL	371.2	13	4	3	3.74	CCCCCCCCc1ccc(CC[C@H](N)C[C@@H](O)P(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL115131	10039	None	0	Human	Binding	IC50	=	7600.00	5.12	-	3	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranes	ChEMBL	355.2	13	2	3	4.13	CCCCCCCCc1ccc(CCC(N)CCS(=O)(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL115554	10108	None	0	Human	Binding	IC50	=	18.00	7.75	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranes	ChEMBL	371.2	13	4	3	3.74	CCCCCCCCc1ccc(CC[C@@H](N)C[C@@H](O)P(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106

Showing 1 to 20 of 484 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)